journal
Journals Genetic Testing and Molecular ...

Genetic Testing and Molecular Biomarkers

https://read.qxmd.com/read/38487920/mir-107-and-mir-126-and-risk-of-breast-cancer-a-case-control-study
#1
JOURNAL ARTICLE
Priyanka Gupta, Vasudha Sambyal, Jagmohan Singh Bali, Kamlesh Guleria, Manjit Singh Uppal, Meena Sudan
Background: Micro RNAs are new diagnostic markers and therapeutic targets in breast cancer research. miR-107 and miR-126 have been reported to be linked with the pathogenesis of breast cancer. The present study investigates the levels of expression of miR-107 and miR-126 in patients with breast cancer to find their correlation with the risk of breast cancer in Amritsar, Punjab, Northwest India. Material and Methods: In total, 200 subjects, 100 patients with breast cancer and 100 controls, were enrolled to screen the expression of miR-107 and miR-126 using quantitative reverse transcription polymerase chain reaction (RT-PCR) technique...
March 15, 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38478803/association-of-timp2-418-g-c-and-mmp-gene-polymorphism-with-risk-of-urinary-cancers-systematic-review-and-meta-analysis
#2
JOURNAL ARTICLE
Pemula Gowtham, Koyeli Girigoswami, Anbazhagan Thirumalai, Karthick Harini, Pragya Pallavi, Agnishwar Girigoswami
Aim: The matrix metalloproteinases (MMPs) inhibit tissue inhibitors of metalloproteinases (TIMPs), playing a notable role in various biological processes, and mutations in TIMP2 genes impact a variety of urinary cancers. In this study, we analyze and evaluate the potential involvement of the TIMP2 418 G/C and MMP gene polymorphism in the etiology of urinary cancer. Methodology: For suitable case-control studies, a literature search was undertaken from various database sources such as PubMed, EMBASE, and Google Scholar...
March 13, 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38478802/ferroptosis-related-genes-are-associated-with-radioresistance-and-immune-suppression-in-head-and-neck-cancer
#3
JOURNAL ARTICLE
Ping Huang, Xuejian Ning, Min Kang, RenSheng Wang
Background: Ferroptosis is associated with tumor development; however, its contribution to radioresistant head and neck cancer (HNC) remains unclear. In this study, we used bioinformatics analysis and in vitro testing to explore ferroptosis-related genes associated with HNCs radiosensitivity. Materials and Methods: GSE9714, GSE90761, and The Cancer Genome Atlas (TCGA) datasets were searched to identify ferroptosis-related differentially expressed genes between radioresistant and radiosensitive HNCs or radiation-treated and nonradiation-treated HNCs...
March 13, 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38471098/association-of-tenascin-c-gene-polymorphisms-with-risk-of-acute-coronary-syndrome-in-south-indian-population-a-case-control-genetic-association-study
#4
JOURNAL ARTICLE
Sankar Abirami, Prashant Shankarrao Adole, Kolar Vishwanath Vinod
Background: The extracellular matrix (ECM) glycoprotein changes are associated with the pathogenesis and complications of atherosclerosis, leading to acute coronary syndrome (ACS). Tenascin-C (TNC), an ECM protein, has been implemented in the pathogenesis, diagnosis, and prognosis of patients with cardiovascular disease. Aim: The study aimed to compare the genetic variants of the TNC gene (rs13321, rs2104772, and rs12347433) between South Indians with ACS and healthy participants. Materials and Methods: This case-control study recruited 150 ACS patients as cases and 150 healthy participants as controls...
March 12, 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38416669/-correction-to-the-correlation-between-clinical-phenotype-and-genotype-of-hereditary-spherocytosis-by-hao-shen-et-al-genet-test-mol-biomarkers-2024-vol-28-no-1-33-38-doi-10-1089-gtmb-2023-0307
#5
(no author information available yet)
No abstract text is available yet for this article.
February 28, 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38359394/a-new-era-for-genetic-testing-and-molecular-biomarkers
#6
JOURNAL ARTICLE
Sharon F Terry
No abstract text is available yet for this article.
February 15, 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38359386/inflammatory-bowel-disease-and-skin-cancer-a-two-sample-mendelian-randomization-analysis
#7
JOURNAL ARTICLE
Aoshuang Li, Mengting Yu, Kaiwen Wu, Lei Liu, Xiaobin Sun
Background: At present, numerous clinical studies suggest a correlation between inflammatory bowel disease (IBD) and skin cancer. However, some articles present differing views that IBD does not increase the risk of skin cancer. The presence of potential reverse causality and residual confounding is inherent in conventional observational studies. Thus, this study used a two-sample Mendelian randomization (MR) study design to estimate the causal effect of IBD on the risk of skin cancer, including cutaneous malignant melanoma (CMM, also named melanoma skin cancer) and nonmelanoma skin cancer (NMSC)...
February 15, 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38416666/profiling-of-long-non-coding-rnas-in-auricular-cartilage-of-patients-with-isolated-microtia
#8
JOURNAL ARTICLE
Run Yang, Yaoyao Fu, Chenlong Li, Yin Chen, Aijuan He, Xin Jiang, Jing Ma, Tianyu Zhang
Introduction: Microtia is the second most common maxillofacial birth defect worldwide. However, the involvement of long non-coding RNAs (lncRNAs) in isolated microtia is not well understood. This study aimed at identifying lncRNAs that regulate the expression of genes associated with isolated microtia. Methods: We used our microarray data to analyze the expression pattern of lncRNA in the auricular cartilage tissues from 10 patients diagnosed with isolated microtia, alongside 15 control subjects. Five lncRNAs were chosen for validation using real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR)...
February 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38416665/identification-and-analysis-of-gene-biomarkers-for-ovarian-cancer
#9
JOURNAL ARTICLE
Xiaodan Wang, Chengmao Xie, Chang Lu
Objective: To identify potential diagnostic markers for ovarian cancer (OC) and explore the contribution of immune cells infiltration to the pathogenesis of OC. Methods: As the study cohort, two gene expression datasets of human OC (GSE27651 and GSE26712, taken as the metadata) taken from the Gene Expression Omnibus (GEO) database were combined, comprising 228 OC and 16 control samples. Analysis was performed to identify the differentially expressed genes between the OC and control samples, while support vector machine analysis using the recursive feature elimination algorithm and least absolute shrinkage and selection operator regression were performed to identify candidate biomarkers that could discriminate OC...
February 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38416664/vitamin-d-receptor-polymorphisms-in-a-spanish-cohort-of-parkinson-s-disease-patients
#10
JOURNAL ARTICLE
Saray Canales-Cortés, Mario Rodríguez-Arribas, María F Galindo, Joaquín Jordan, Ignacio Casado-Naranjo, José M Fuentes, Sokhna M S Yakhine-Diop
Background: Vitamin D receptor (VDR) is a nuclear hormone receptor widely expressed in the substantia nigra. Its association with an increased risk of Parkinson's disease (PD) is based on vitamin D deficiency and/or different polymorphisms in its gene receptor. This fact has been demonstrated by several case-control studies. Materials and Methods: Consequently, we investigated the association between VDR Apa I, Bsm I, Fok I, and Taq I gene polymorphisms and PD in a Spanish cohort that included 54 cases and 17 healthy controls...
February 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38416663/upregulation-of-long-noncoding-rna-pcat1-in-iranian-patients-with-colorectal-cancer-and-its-performance-as-a-potential-diagnostic-biomarker
#11
JOURNAL ARTICLE
Negin Sadi Khosroshahi, Shabnam Koulaeizadeh, Adel Abdi, Sama Akbarzadeh, Seyed Mehran Hashemi Aghdam, Ali Rajabi, Reza Safaralizadeh
Background: Long noncoding RNAs (lncRNAs) as critical molecules play an essential role in the development of cancers. In colorectal cancer (CRC), various lncRNAs are related to cell proliferation, apoptosis, migration, and invasion. LncRNA prostate cancer-associated transcript 1 ( PCAT-1 ), as an oncogenic factor, is a diagnostic biomarker that regulates cell proliferation, migration, invasion, and apoptosis. Methods: This study evaluated the relationship between PCAT-1 , CRC occurrence, and pathological features of Iranian patients...
February 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38416662/association-of-interleukin-17a-and-interleukin-17f-gene-polymorphisms-with-atopic-dermatitis-in-chinese-children
#12
JOURNAL ARTICLE
Chen Shen, Yunling Li, Jian Huang, Jing Li, Guoqiang Qi, Zhu Zhu, Huiwen Zheng
Background: Atopic dermatitis (AD) is a chronic, recurrent inflammatory disease associated with an unbalanced immune response in the upper layers of the skin tissue, mostly starting in childhood. As important factors in gene expression regulation, polymorphisms in interleukin (IL)-17A and IL-17F may be associated with the susceptibility and severity of AD. Methods: Blood samples and clinical information were obtained from 132 patients with AD and 100 healthy children. Using multiplex polymerase chain reaction and next-generation sequencing, five potential single-nucleotide polymorphisms (SNPs) of IL-17A and IL-17F were genotyped in all participants...
February 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38294359/toward-the-future-perspectives-on-the-impacts-of-genetic-testing-and-biomarkers-on-advancing-health-care
#13
EDITORIAL
Jane Gibson
No abstract text is available yet for this article.
January 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38294358/characterization-of-prognostic-apoptosis-related-gene-signature-to-evaluate-glioma-immune-microenvironment-and-experimental-verification
#14
JOURNAL ARTICLE
Hao Yu, Jiapeng Yu, Minjie Wang, Xiaobing Jiang
Purpose: Recently, apoptosis-related genes were shown to modulate cancer immunity. However, the role of apoptosis-related genes in the glioma immune microenvironment (GIME) remains unknown. This study aimed to explore the prognostic value of apoptosis-related genes in glioma. Methods: Doxorubicin was used to induce glioma cell apoptosis, and four differentially expressed apoptosis-related genes were identified: CREM , TNFSF12 , PEA15 , and PRKCD . Kaplan-Meier analyses, receiver operating characteristic curve analyses, and nomograms were established to determine the relationship between risk markers and the prognosis of patients with glioma...
January 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38294357/-egln1-a-biomarker-of-poor-prognosis-of-cervical-cancer-and-a-target-of-treatment
#15
JOURNAL ARTICLE
Yi-Ting Zhang, Lin-Jing Xu, Ling Li
Objective: To conduct bioinformatics analysis on the prognostic effect, mechanism of action, and drug sensitivity of Egl-9 family hypoxia-inducible factor 1 ( EGLN1 ) expression on cervical cancer. Methods: Bioinformatics were obtained from Gene Expression Profiling Interactive Analysis (GEPIA), Tumor Immune Estimation Resource (TIMER), and the human cancer metastasis database (HCMDB), and the effect of EGLN1 expression level on the prognosis of cervical cancer was comprehensively analyzed. The protein-protein interaction network was constructed by Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), and the possible mechanism of EGLN1 affecting the prognosis of cervical cancer was discussed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis...
January 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38294356/determination-of-the-relationship-between-the-development-and-recurrence-of-subacute-thyroiditis-and-human-leukocyte-antigen-subtypes
#16
JOURNAL ARTICLE
Fatma Nur Korkmaz, Asena Gökçay Canpolat, Klara Dalva, Atilla Halil Elhan, Mustafa Şahin, Demet Çorapçıoğlu, Özgür Demir
Background: There are several studies investigating the role of human leukocyte antigens (HLA) in the development and recurrence of subacute thyroiditis (SAT). The HLA subtypes associated with SAT were usually determined in a population-based manner and HLA-B*35 , HLA-B*18:01 , HLA-C*04:01 , and HLA-DRB1*01 were detected to play a role in the disease susceptibility and prognosis. The aim of this study was to determine HLA alleles associated with the tendency of recurrence and prevention of SAT within the Turkish population...
January 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38294355/the-correlation-between-clinical-phenotype-and-genotype-of-hereditary-spherocytosis
#17
JOURNAL ARTICLE
Hao Shen, Zhigang Gao, Qing Ye
Objective: Hereditary spherocytosis (HS) is a common hereditary hemolytic disease. This study aimed to explore the correlation between the phenotype and mutant genotype of HS to improve the clinical understanding of HS. Methods: This study reported a case of spontaneous mutation of the ANK1 gene in HS, reviewed previous studies on the genotype-phenotype correlation of HS, statistically analyzed the main types of gene mutations in HS, and summarized the clinical data of patients. Results: This patient had clinical manifestations of anemia, splenomegaly, peripheral blood smear with increased spherocytosis, and bilirubin, confirmed as ANK1 gene mutant HS by gene detection...
January 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38294354/acknowledgment-of-reviewers-2023
#18
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38156909/identification-of-irf1-as-a-novel-pyroptosis-related-prognostic-biomarker-of-atopic-dermatitis
#19
JOURNAL ARTICLE
Xin Liu, Yi Wang, Ruofan Xi, Dongjie Guo, Wanjun Guo, Linyan Cheng, Ting Du, Hanzhi Lu, Peiyao Wang, Yanjuan Duan, Jianyong Zhu, Fulun Li
Purpose: The aim of this study was to characterize key biomarkers associated with pyroptosis in atopic dermatitis (AD). Materials and methods: To identify the differentially expressed pyroptosis-related genes (DEPRGs), the gene expression profiles GSE16161 and GSE32924 from the Gene Expression Omnibus (GEO) database were utilized. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to determine the potential biological functions and involved pathways...
December 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38156908/farewell
#20
EDITORIAL
Garth D Ehrlich
No abstract text is available yet for this article.
December 2023: Genetic Testing and Molecular Biomarkers
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