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Journal of Hematopathology

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https://www.readbyqxmd.com/read/27766121/transformation-of-cll-to-alcl-the-role-of-clonality-studies-in-diagnostic-molecular-haematopathology
#1
Richard Colling, Daniel Royston, Elizabeth Soilleux
Clonality studies greatly assist in the diagnosis of challenging haematopathology cases. These robust and standardised tests aid the detection of clonal lymphoid populations and may assist in lymphocyte subtyping. In this case report, a gentleman presented with a high-grade transformation of a B cell neoplasm which histologically and immunophenotypically mimicked a T cell anaplastic large-cell lymphoma. With the aid of T cell and B cell receptor clonality studies, it was demonstrated that this tumour was in fact of B cell lineage...
September 2016: Journal of Hematopathology
https://www.readbyqxmd.com/read/27766120/new-developments-in-the-pathology-of-malignant-lymphoma-a-review-of-the-literature-published-from-june-august-2016
#2
J Han van Krieken
No abstract text is available yet for this article.
September 2016: Journal of Hematopathology
https://www.readbyqxmd.com/read/27398102/new-developments-in-the-pathology-of-malignant-lymphoma-a-review-of-the-literature-published-from-january-april-2016
#3
J Han van Krieken
No abstract text is available yet for this article.
June 2016: Journal of Hematopathology
https://www.readbyqxmd.com/read/27398101/how-we-do-optimizing-bone-marrow-biopsy-logistics-for-sign-out-within-2%C3%A2-days
#4
I de Laak-de Vries, A G Siebers, L Burgers, C Diepenbroek, M Link, P Groenen, J H J M van Krieken, K M Hebeda
Since the introduction of fast diagnostic tracks in many areas of oncology, the traditional processing of bone marrow biopsies (BMB), requiring either resin embedding or lengthy fixation and decalcification, is due to an upgrade. Thanks to a growing number of new commercially available tissue processors, microwave-enhanced processing is becoming a standard tool in the pathology laboratory, allowing rapid fixation and decalcification of BMB with preserved morphology and antigens. In this short report, we describe the use of a commercially available EDTA-based decalcification fluid (USEDECALC, Medite, Orlando, USA) in combination with the LOGOS J (Milestone, Bergamo, Italy), a closed microwave-enhanced tissue processor, for overnight fixation, decalcification, and paraffin impregnation of the BMB...
June 2016: Journal of Hematopathology
https://www.readbyqxmd.com/read/26949423/new-developments-in-the-pathology-of-malignant-lymphoma-a-review-of-the-literature-published-from-september-2015-december-2015
#5
J Han van Krieken
No abstract text is available yet for this article.
March 2016: Journal of Hematopathology
https://www.readbyqxmd.com/read/26949422/a-subset-of-low-grade-b-cell-lymphomas-with-a-follicular-growth-pattern-but-without-a-bcl2-translocation-shows-features-suggestive-of-nodal-marginal-zone-lymphoma
#6
Michiel van den Brand, Olga Balagué, Patricia H J van Cleef, Patricia J T A Groenen, Konnie M Hebeda, Daphne de Jong, J Han J M van Krieken
In our consultation practice, it was noted that many cases that were considered to represent follicular lymphoma (FL) without a BCL2 translocation were ultimately classified as nodal marginal zone lymphoma (NMZL). This study set out to define recurrent morphological features of these cases. Thirty-three low-grade B cell lymphomas without a BCL2 rearrangement were studied for recurrent morphological features. These features were then applied on 20 randomly selected cases to verify if these criteria are able to distinguish between lymphomas with and without a BCL2 rearrangement, assigning them to one of five categories ranging from "certain FL" to "certain NMZL...
March 2016: Journal of Hematopathology
https://www.readbyqxmd.com/read/27559423/cerebellar-ebv-associated-diffuse-large-b-cell-lymphoma-following-angioimmunoblastic-t-cell-lymphoma
#7
Yi Zhou, Marc K Rosenblum, Ahmet Dogan, Achim A Jungbluth, April Chiu
Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4 months after the initial diagnosis of AITL...
December 2015: Journal of Hematopathology
https://www.readbyqxmd.com/read/26640600/new-developments-in-the-pathology-of-malignant-lymphoma-a-review-of-the-literature-published-from-may-2015-september-2015
#8
J Han van Krieken
No abstract text is available yet for this article.
December 2015: Journal of Hematopathology
https://www.readbyqxmd.com/read/26753010/myeloid-proliferations-associated-with-down-syndrome
#9
Alan B Cantor
No abstract text is available yet for this article.
September 2015: Journal of Hematopathology
https://www.readbyqxmd.com/read/26609329/myeloproliferative-neoplasms-in-children
#10
Inga Hofmann
Myeloproliferative neoplasms (MPN) are a group of clonal hematopoietic stem cell disorders characterized by aberrant proliferation of one or more myeloid lineages often with increased immature cells in the peripheral blood. The three classical BCR-ABL-negative MPNs are: 1) polycythemia vera (PV), 2) essential thrombocythemia (ET), and 3) primary myelofibrosis (PMF), which are typically disorders of older adults and are exceedingly rare in children. The diagnostic criteria for MPNs remain largely defined by clinical, laboratory and histopathology assessments in adults, but they have been applied to the pediatric population...
September 2015: Journal of Hematopathology
https://www.readbyqxmd.com/read/26146524/new-developments-in-the-pathology-of-malignant-lymphoma-a-review-of-literature-published-from-january-2015-to-april-2015
#11
J Han van Krieken
No abstract text is available yet for this article.
June 2015: Journal of Hematopathology
https://www.readbyqxmd.com/read/25798206/new-developments-in-the-pathology-of-malignant-lymphoma-a-review-of-the-literature-published-from-october-2014-december-2014
#12
J Han van Krieken
No abstract text is available yet for this article.
March 2015: Journal of Hematopathology
https://www.readbyqxmd.com/read/25478033/detection-of-ebv-in-reactive-and-neoplastic-lymphoproliferations-in-adults-when-and-how
#13
Christiane Stuhlmann-Laeisz, Ilske Oschlies, Wolfram Klapper
Lymphoproliferations associated with Epstein-Barr Virus (EBV) in adult patients pose a diagnostic challenge for pathologists for several reasons. First, the EBV lymphoproliferations represent a clinically and histologically very broad spectrum ranging from self-limiting lymphoproliferations to manifest malignant lymphomas. Second, the classification of these diseases is not solely based on histopathology but rather requires a synopsis of clinical as well as pathological features. And third, a resource-efficient diagnostic procedure demands a deliberate strategy for selecting the tissue specimens that are to be tested for EBV...
December 2014: Journal of Hematopathology
https://www.readbyqxmd.com/read/25937841/fasn-and-cd36-predict-survival-in-rituximab-treated-diffuse-large-b-cell-lymphoma
#14
Olga V Danilova, Larry J Dumont, Norman B Levy, Frederick Lansigan, William B Kinlaw, Alexey V Danilov, Prabhjot Kaur
Diffuse large B-cell lymphoma is the most common lymphoid malignancy, as it accounts for approximately one third of all patient cases of non-Hodgkin's lymphoma. Patients with diffuse large B-cell lymphoma have markedly different treatment outcomes, suggesting a need for reliable prognostic factors and novel therapeutic approaches. De novo fatty acid synthesis is an important metabolic driver of tumor in multiple malignancies. In this retrospective study, we analyzed expression of fatty acid synthase (a key enzyme in de novo fatty acid synthesis), Spot 14 (thyroid hormone responsive Spot 14, a nuclear protein that promotes expression of genes involved in fatty acid synthesis), and CD36 (the cell surface channel for exogenous fatty acid uptake) in patients with diffuse large B-cell lymphoma and their clinical significance...
March 2013: Journal of Hematopathology
https://www.readbyqxmd.com/read/24307917/early-lesions-in-lymphoid-neoplasia-conclusions-based-on-the-workshop-of-the-xv-meeting-of-the-european-association-of-hematopathology-and-the-society-of-hematopathology-in-uppsala-sweden
#15
Falko Fend, José Cabecadas, Philippe Gaulard, Elaine S Jaffe, Philip Kluin, Isinsu Kuzu, Loann Peterson, Andrew Wotherspoon, Christer Sundström
The increasing use of immunophenotypic and molecular techniques on lymphoid tissue samples without obvious involvement by malignant lymphoma has resulted in the increased detection of "early" lymphoid proliferations, which show some, but not all the criteria necessary for a diagnosis of malignant lymphoma. In most instances, these are incidental findings in asymptomatic individuals, and their biological behaviour is uncertain. In order to better characterize these premalignant conditions and to establish diagnostic criteria, a joint workshop of the European Association for Haematopathology and the Society of Hematopathology was held in Uppsala, Sweden, in September 2010...
September 2012: Journal of Hematopathology
https://www.readbyqxmd.com/read/25089161/mantle-cell-lymphoma-with-features-of-marginal-zone-lymphoma
#16
Ulla Randen, Olav Erich Yri, Anne Tierens, Sverre Heim, Klaus Beiske, Jan Delabie
We present seven cases of mantle cell lymphoma with morphological features of marginal-zone lymphoma. Of particular interest, four of the patients had predominant involvement of the gastrointestinal tract. All cases displayed the translocation t(11;14)(q13;q32) and expressed cyclin D1. Cytogenetic analysis revealed trisomy 3 in one case and somatic hypermutation of immunoglobulin heavy genes could be demonstrated in two out of four cases. The latter features are reminiscent of marginal-zone lymphoma. The localization of these lymphomas mainly in the gastrointestinal tract and the higher exposure to antigens in this area may explain why this variant of mantle cell lymphoma harbours features of marginal-zone lymphoma...
March 2011: Journal of Hematopathology
https://www.readbyqxmd.com/read/21633487/new-developments-in-the-pathology-of-malignant-lymphoma-a-review-of-the-literature-published-from-october-2009-to-january-2010
#17
J Han van Krieken
No abstract text is available yet for this article.
June 2010: Journal of Hematopathology
https://www.readbyqxmd.com/read/21625283/epstein-barr-virus-and-hodgkin-s-lymphoma-in-cairo-egypt
#18
Josée Audouin, Jacques Diebold, Bharat Nathwani, Elia Ishak, Kenneth Maclennan, Hans Konrad Mueller-Hermelink, James O Armitage, Dennis D Weisenburger
Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype...
June 2010: Journal of Hematopathology
https://www.readbyqxmd.com/read/21593985/hematopathology-in-the-new-decade-what-to-expect
#19
J Han van Krieken
No abstract text is available yet for this article.
2010: Journal of Hematopathology
https://www.readbyqxmd.com/read/21544187/therapy-related-myelodysplastic-syndrome-presenting-as-fulminant-heart-failure-secondary-to-myeloid-sarcoma
#20
Kristina A Matkowskyj, William R Wiseman, Jason C Robin, John P Norvell, Jyothy Puthumana, Beverly Nelson, Loann Peterson, Thomas J McGarry, Warren G Tourtellotte
Rapidly progressive heart failure is commonly caused by an extensive myocardial infarction, a mechanical complication of infarction, myocarditis, or acute valvular insufficiency. We present an unusual case that was caused by a diffuse infiltration of the myocardium with leukemic cells (myeloid sarcoma). The patient presented with episodic shortness of breath, he was anemic and thrombocytopenic, and his bone marrow biopsy revealed myelodysplastic syndrome from treatment for oligodendroglioma. His clinical course was characterized by a chronic leak of cardiac enzymes, a new right bundle branch block, and a large pericardial effusion causing tamponade and death from fulminant heart failure and ventricular arrhythmias within 2 weeks...
2010: Journal of Hematopathology
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