journal
MENU ▼
Read by QxMD icon Read
search

Surgical Pathology Clinics

journal
https://www.readbyqxmd.com/read/29751886/hepatic-pathology-evolving-concepts-in-diagnosis-and-pathogenesis-for-medical-diseases-and-tumors
#1
EDITORIAL
John Hart
No abstract text is available yet for this article.
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751885/frozen-sections-of-the-liver
#2
REVIEW
Meredith E Pittman, Rhonda K Yantiss
Intraoperative consultation requires skills in gross examination and histologic diagnosis, as well as an ability to perform rapid interpretations under time constraints. The aim of this review is to provide surgical pathologists with a framework for dealing with hepatic specimens in the frozen section area by covering common clinical scenarios and histologic findings. Differential diagnoses are considered in relation to primary hepatic neoplasia and metastatic diseases. Benign mimics of malignancy and other pitfalls in frozen section diagnosis of lesional tissue are covered...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751884/acute-chronic-and-humoral-rejection-pathologic-features-under-current-immunosuppressive-regimes
#3
REVIEW
Jamie Koo, Hanlin L Wang
Under current immunosuppressive regimes, T-cell-mediated acute and chronic rejection remain common and important posttransplant complications. The definition of humoral (antibody-mediated) rejection has been greatly expanded in recent years. The histopathologic assessment of allograft biopsies continues to serve an important role in the diagnosis of rejection and to facilitate patient management. The diagnosis of both acute and chronic antibody-mediated rejection requires integration of the results of donor-specific antibody testing and C4d immunostaining, as well as exclusion of other potential etiologies of allograft dysfunction...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751883/cholangiocarcinoma
#4
REVIEW
Alyssa M Krasinskas
This article focuses on cholangiocarcinoma, both intrahepatic and extrahepatic. The various classification schemes based on anatomic location, macroscopic growth pattern, microscopic features, and cell of origin are outlined. The clinicopathologic, immunohistochemical and molecular differences between intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, as well as differences in the 2 subtypes of intrahepatic cholangiocarcinoma, are discussed. Finally, precursor lesions, prognosis, treatment, and promising new potential targeted therapies are reviewed...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751882/hepatic-lymphoma-diagnosis
#5
REVIEW
Won-Tak Choi, Ryan M Gill
Systemic hematopoietic disorders may present on liver biopsy, and rare cases of primary hepatic lymphoma (PHL) may be encountered. Hepatopathologists must be familiar with the full spectrum of hematopoietic disorders involving the liver and be prepared to exclude benign mimics. PHL, which is confined to the liver without extrahepatic involvement, can present as solitary or multiple nodules, raising consideration for carcinoma on imaging, or may mimic benign inflammatory conditions, posing a diagnostic challenge...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751881/fibrolamellar-carcinoma-what-is-new-and-why-it-matters
#6
REVIEW
Rondell P Graham
Fibrolamellar carcinoma is distinctive at clinical and histologic levels. A novel DNAJB1-PRKACA fusion gene characterizes almost all cases, distinguishes it from other hepatocellular neoplasms, and drives the pathogenesis of this unique tumor. A subset of cases of fibrolamellar carcinoma is associated with alternate mechanisms of protein kinase A activation. This review article discusses common and unusual histologic features of fibrolamellar carcinoma, its differential diagnoses, and how to make the diagnosis while avoiding key pitfalls...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751880/update-on-ancillary-testing-in-the-evaluation-of-high-grade-liver-tumors
#7
REVIEW
Anne Koehne de Gonzalez, Stephen M Lagana
Tissue diagnosis is the gold standard for mass lesions of the liver, but needle core biopsies may sometimes prove challenging. Presented here is a review of a panel of immunohistochemical stains, including hepatocyte in paraffin 1, arginase-1, polyclonal carcinoembryonic antigen, CD10, bile salt export pump, glypican-3, as well as in situ hybridization for albumin RNA, to establish hepatocellular origin in cases in which hepatocellular carcinoma is suspected but the sample is limited or the morphology is challenging, as it may be with cases of scirrhous, fibrolamellar carcinoma, intrahepatic cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751879/hepatic-adenomas-classification-controversies-and-consensus
#8
REVIEW
Michael Torbenson
Rapid advances in molecular and anatomic pathology have greatly improved our understanding of hepatocellular adenomas. Principle among them is a clinically relevant, histology-based classification that identifies hepatic adenomas at greatest risk for malignant transformation. This new classification system has led to general consensus on the major subtypes of hepatic adenomas. However, controversy remains regarding how to incorporate less common types of hepatic adenomas into the classification system and how to incorporate adenoma subtyping into clinical care...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751878/primary-biliary-cholangitis-and-autoimmune-hepatitis
#9
REVIEW
Raul S Gonzalez, Kay Washington
Primary biliary cholangitis and autoimmune hepatitis are common autoimmune diseases of the liver. Both have typical clinical presentations, including certain autoantibodies on serologic testing. Histologic features are also often typical: primary biliary cholangitis shows bile duct destruction (sometimes with granulomas), and autoimmune hepatitis shows prominent portal and lobular lymphoplasmacytic inflammation. Both have a wide differential diagnosis, including one another; they may also simultaneously occur within the same patient...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751877/pathologic-features-of-hereditary-cholestatic-diseases
#10
REVIEW
Andrew D Clouston
The inherited diseases causing conjugated hyperbilirubinemia are diverse, with variability in clinical severity, histologic appearance, and time of onset. The liver biopsy appearances can also vary depending on whether the initial presentation is in the neonatal period or later. Although many of the disorders have specific histologic features in fully developed and classic cases, biopsies taken early in the disease course may be nonspecific, showing either cholestatic hepatitis or an obstructive pattern of injury requiring close correlation with the laboratory and clinical findings to reach the correct diagnosis...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751876/recent-advances-in-the-histopathology-of-drug-induced-liver-injury
#11
REVIEW
David E Kleiner
Drug-induced liver injury (DILI) is constantly changing as new drugs are approved and as new herbals and dietary supplements (HDS) reach the market. The pathologist plays a key role in the evaluation of DILI by classifying and interpreting the histologic findings considering patients' medical history and drug exposure. The liver biopsy findings may suggest alternative explanations of the injury and additional testing that should be performed to exclude non-DILI causes. Recent reports of iatrogenic liver injury are reviewed with attention to immunomodulatory and antineoplastic agents as well as reports of injury associated with HDS use...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751875/chronic-hepatitis-c-and-direct-acting-antivirals
#12
REVIEW
Maria Westerhoff, Joseph Ahn
The hepatitis C virus (HCV) is the most common blood-borne infection in the United States and is the most common cause of end-stage liver disease requiring liver transplant. Over the last 10 years, direct acting antiviral therapies have revolutionized HCV treatment, increasing the cure rates from less than 50% to more than 90% in those who reach access to care. This article is an overview for pathologists and clinicians covering the histologic findings of HCV as well as direct acting antiviral therapy.
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751874/nonalcoholic-steatohepatitis-histopathology-basics-within-a-broader-context
#13
REVIEW
Michael H Schild, Cynthia D Guy
Nonalcoholic fatty liver disease (NAFLD) is a major health concern and the prevalence continues to increase in many industrialized and developing countries around the world. NAFLD affects adults and children. NAFLD-related cirrhosis is expected to become the top indication for liver transplantation in the near future, and the incidence of NAFLD-related hepatocellular carcinoma is also increasing. Nonalcoholic steatohepatitis is the more severe form of NAFLD. The pathogenesis of NALFD/nonalcoholic steatohepatitis is complex and new concepts continue to evolve...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751873/acute-viral-hepatitis-beyond-a-b-and-c
#14
REVIEW
Venancio Avancini Ferreira Alves
From the standpoint of the surgical pathologist "hepatitis" is defined as the set of histologic patterns of lesions found in livers infected by hepatotropic viruses, by non-hepatotrophic viruses leading to liver inflammation in the context of systemic infection, or due to an autoimmune disease, drug, or toxin involving the liver. This article is centered on the histologic patterns of injury in acute viral hepatitis, encompassing the hepatotropic viruses A, B, C, D, and E and the "icteric hemorrhagic fevers" (dengue, hantavirus, yellow fever)...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751872/granulomas-in-the-liver-with-a-focus-on-infectious-causes
#15
REVIEW
Eun-Young Karen Choi, Laura W Lamps
Hepatic granulomas are encountered in approximately 2% to 10% of liver biopsies. There are many potential infectious and noninfectious causes; granulomas can be generally classified by their morphology, which may be helpful in refining the differential diagnosis. This article provides a review of hepatic granulomas with an emphasis on infectious causes.
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29413665/contemporary-topics-in-breast-pathology
#16
EDITORIAL
Laura C Collins
No abstract text is available yet for this article.
March 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29413662/breast-pathology
#17
Laura C Collins
No abstract text is available yet for this article.
March 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29413661/differential-diagnosis-of-benign-spindle-cell-lesions
#18
REVIEW
Gaetano Magro
Spindle cell lesions of the breast cover a wide spectrum of diseases ranging from reactive tumor-like lesions to high-grade malignant tumors. The recognition of the benign spindle cell tumor-like lesions (nodular fasciitis; reactive spindle cell nodule after biopsy, inflammatory pseudotumor/inflammatory myofibroblastic tumor; fascicular variant of pseudoangiomatous stromal hyperplasia) and tumors (myofibroblastoma, benign fibroblastic spindle cell tumor, leiomyoma, schwannoma, spindle cell lipoma, solitary fibrous tumor, myxoma) is crucial to avoid confusion with morphologically similar but more aggressive bland-appearing spindle cell tumors, such as desmoid-type fibromatosis, low-grade (fibromatosis-like) spindle cell carcinoma, low-grade fibrosarcoma/myofibroblastic sarcoma and dermatofibrosarcoma protuberans...
March 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29413660/an-update-of-mucinous-lesions-of-the-breast
#19
REVIEW
Beth T Harrison, Deborah A Dillon
Mucinous lesions of the breast include a variety of benign and malignant epithelial processes that display intracytoplasmic or extracellular mucin, including mucocelelike lesions, mucinous carcinoma, solid papillary carcinoma, and other rare subtypes of mucin-producing carcinoma. The most important diagnostic challenge is the finding of free-floating or stromal mucin accumulations for which the significance depends on the clinical, radiologic, and pathologic context. This article emphasizes the differential diagnosis between mucocelelike lesions and mucinous carcinoma, with a brief consideration of potential mimics, such as biphasic and mesenchymal lesions with myxoid stroma ("stromal mucin") and foreign material...
March 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29413659/axillary-lymph-node-inclusions
#20
REVIEW
Ashley Cimino-Mathews
Lymph node inclusions can occur in axillary lymph nodes, where they can mimic metastatic breast carcinoma. This article provides an overview of epithelial and nonepithelial lymph node inclusions, including mammary-type glandular inclusions, Mullerian-type glandular inclusions, squamous inclusions, mixed glandular-squamous inclusions, and nodal nevi. The discussion emphasizes the histologic and immunophenotypic features and differential diagnoses of each entity.
March 2018: Surgical Pathology Clinics
journal
journal
42198
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"