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American Journal of Rhinology & Allergy

Zhi-Qiang Guo, Wei-Yang Dong, Jian Xu, Zhi-Cong Hong, Ren-Wu Zhao, Cong-Rui Deng, Guo-Shun Zhuang, Ru-Xin Zhang
BACKGROUND: Exposure to fine particulate matter (particulate matter less than or equal to 2.5 mg [PM2.5]) increases therisk of allergic rhinitis (AR), but the underlying mechanisms remains unclear. Thus, we investigated the roles of T-helper (Th)1-Th2 cytokines and nasal remodeling after ambient PM2.5 exposure in a rat model of AR. METHODS: Female Sprague-Dawley rats were randomized into six groups: a negative control group, a group of healthy rats exposed to 3000 mg/m3 PM2...
April 11, 2017: American Journal of Rhinology & Allergy
S E Chiarella, H Sy, A T Peters
Chronic rhinosinusitis (CRS) affects 12.5% of the U.S. POPULATION: CRS can be divided into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps. Some individuals with CRSwNP do not respond to standard-of-care medical and surgical management. For these individuals, targeted biologic agentsare emerging as an important therapeutic alternative. In this review, we described the most-relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-interleukin 5 (mepolizumab and reslizumab), and anti-interleukin 4/interleukin 13 (dupilumab) monoclonal antibodies for the treatment of CRSwNP...
March 9, 2017: American Journal of Rhinology & Allergy
K Omura, D Asaka, J Nayak, Y Tanaka
INTRODUCTION: Recently, the surgical management of nasal tumors has been greatly influenced by advanced endoscopic techniques. To achieve complete endoscopic resection of large obstructing nasal tumors, a sufficient corridor for adequate exposure is also required. In the Japanese language, TACMI means "master expert," and herein we describe an endoscopic technique with novel elements that we term transseptal access with crossing multiple incisions (TACMI). This approach enables a direct transseptal approach to the pedicle through tumor transposition while allowing complete septal reconstruction and stability...
February 15, 2017: American Journal of Rhinology & Allergy
Saeid Atighechi, Batool Sadat Sajadinejad, Mohammad Farhadi, Mohammadali Ahmadpour-Baghdadabad
OBJECTIVE: We proposed a novel technique for the quantitative examination of tip recoil. The technique measures nasal tip strain as an objective measure of tip recoil. We used the term tip recoilometry to refer to this measurement technique. DESIGN: We performed case studies in two phases. Phase 1 included 30 candidates with normal tip recoil and 30 candidates with weak tip recoil. Phase 2 included 40 patients who had undergone open rhinoplasty surgery by either columella strut or caudal extension graft methods...
January 31, 2017: American Journal of Rhinology & Allergy
Federica Di Berardino, Diego Zanetti, Gennaro D'Amato
BACKGROUND: Nasal rinsing with an atomizer spray was found to be effective in the treatment of allergic rhinitis. Two parameters express the nasal functions: (1) mucociliary clearance (MCC), and (2) the pH and its stability. MCC is the main factor that defines the time of pollen transition on the nasal mucosa and, therefore, the amount of the allergen glycoprotein elution. OBJECTIVE: We hypothesized that the nasal wash efficacy could be due to the reduction of contact time of the grass pollen on the nasal mucosa (improving MCC)...
January 26, 2017: American Journal of Rhinology & Allergy
Nanna Juel-Berg, Peter Darling, Julie Bolvig, Majken H Foss-Skiftesvik, Susanne Halken, Lone Winther, Kirsten Skamstrup Hansen, Nikolaj Askjaer, Steffen Heegaard, Anders R Madsen, Morten S Opstrup
BACKGROUND: Intranasal corticosteroids (INS) (corticosteroid nasal sprays) and oral antihistamines (OA) are two of the most common treatments for patients with allergic rhinitis (AR). To our knowledge, there are no systematic reviews on this topic including trials published after 2007. OBJECTIVE: To compare INS with nonsedating OAs as treatments for AR. METHODS: The systematic review and meta-analysis were based on the Grades of Recommendation, Assessment, Development, and Evaluation principles and the Patient, Intervention, Comparison, and Outcome approach...
January 9, 2017: American Journal of Rhinology & Allergy
Ronald G Amedee
No abstract text is available yet for this article.
January 1, 2017: American Journal of Rhinology & Allergy
Hasan Cetiner, Ilker Cavusoglu, Sertac Duzer
BACKGROUND: The relationship between septal perforation and smoking (of cigarettes) was not previously studied in patients who underwent septoplasty. OBJECTIVE: To evaluate the effect of smoking on nasal septal perforation development and the postoperative healing process in patients who underwent septoplasty. METHODS: Medical records of patients who underwent septoplasty procedures between January 2010 and December 2014 were retrospectively reviewed...
January 1, 2017: American Journal of Rhinology & Allergy
Rafaela Veloso-Teles, Rui Cerejeira
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly prevalent disease of the nasal cavity and paranasal sinus, but its exact etiology is still unclear and remains a difficult-to-treat condition. HYPOTHESIS: Endoscopic sinus surgery (ESS) is an effective treatment for medically recalcitrant CRSwNP. There are independent variables that can predict surgical outcomes in patients with CRSwNP. OBJECTIVES: To evaluate ESS efficacy in CRSwNP treatment and to establish prognostic factors for disease recurrence...
January 1, 2017: American Journal of Rhinology & Allergy
Xiao-Dan Jiang, Qing-Zhe Dong, Shen-Ling Li, Tian-Qiao Huang, Nian-Kai Zhang
BACKGROUND: Sinonasal inverted papilloma (SNIP) is noted for its high rate of recurrence and malignant transformation. Although many clinical studies have demonstrated the effectiveness of the endoscopic approach for SNIP, the surgical strategy has been the subject of much debate. OBJECTIVE: To evaluate the effectiveness of the endoscopic endonasal approach in SNIP. METHODS: A systematic review of patients with a diagnosis of SNIP and who had surgery at our institution from June 2005 to March 2013 was performed...
January 1, 2017: American Journal of Rhinology & Allergy
Christopher D Brook, Alice Z Maxfield, Hena Ahmed, Ahmad R Sedaghat, Eric H Holbrook, Stacey T Gray
BACKGROUND: Risk factors in adult patients with cystic fibrosis (CF) associated with surgical intervention have not been delineated. OBJECTIVE: To identify characteristics of adult patients with CF and with chronic rhinosinusitis that predict surgical intervention with endoscopic sinus surgery (ESS). METHODS: Patients were identified in a tertiary sinus center by the International Classification of Diseases, Ninth Revision codes 277.00-277...
January 1, 2017: American Journal of Rhinology & Allergy
Oshri Wasserzug, Israel Kaffe, Towy Sorel Lazarovici, Tal Weissman, Ran Yahalom, Dan M Fliss, Noam Yarom
BACKGROUND: The use of bisphosphonates is very common among patients with osteoporosis and multiple myeloma as well as those with bone metastases from various malignancies. The benefits of bisphosphonates are well recognized, but it became evident during the past decade that these medications portend the major adverse effect of osteonecrosis of the jaw, known as bisphosphonate-related osteonecrosis of the jaw. OBJECTIVE: Our aim was to evaluate the specific manifestations of bisphosphonate use on the maxillary sinus in patients with documented bisphosphonate-related osteonecrosis of the jaw...
January 1, 2017: American Journal of Rhinology & Allergy
Dan Yaniv, Lena Shlosberg, Joseph Flomenblit, Gregory Frenklach, Lea Rath-Wolfson, Eitan Yaniv
BACKGROUND: The goal of endoscopic sinus surgery in chronic sinusitis is to create good drainage of the paranasal sinuses. Metal stents used to prevent lateralization of the middle concha are associated with adverse effects. OBJECTIVE: The aim of this experimental study was to evaluate the feasibility and safety of a newly developed composite removable stent. METHODS: The composite removable stent was implanted in nine sheep (18 stents) in the ethmoid cavity after performing an ethmoidectomy and was examined for stability, ease of removal, and adverse effects...
January 1, 2017: American Journal of Rhinology & Allergy
Bohai Feng, Jueting Wu, Bobei Chen, Haijie Xiang, Ruru Chen, Bangliang Li, Si Chen
BACKGROUND: Allergic rhinitis (AR) has become a global health problem that constantly affects a large part of the general population, especially children. OBJECTIVE: Sublingual allergen immunotherapy (SLIT) has been used extensively for pediatric AR, although its efficacy and safety are often questioned. In this meta-analysis of randomized controlled trials (RCT), we evaluated the use of SLIT for pediatric AR. METHODS: A number of medical literature data bases were searched through January 2016 to identify RCTs that examined the use of SLIT for pediatric AR and that assessed clinical outcomes related to efficacy...
January 1, 2017: American Journal of Rhinology & Allergy
John R Scott, Hannah M J Ernst, Brian W Rotenberg, Luke Rudmik, Leigh J Sowerby
BACKGROUND: In the field of otolaryngology, oral corticosteroids (OCS) are widely prescribed for rhinosinusitis. Although there is evidence in the literature regarding specific OCS dosing protocols, it is not known to what extent these recommendations are being followed. OBJECTIVE: To examine the current state of OCS prescribing habits for rhinosinusitis by American Rhinologic Society members. METHODS: An anonymous online survey was sent to all American Rhinologic Society members...
January 1, 2017: American Journal of Rhinology & Allergy
Brian D'Anza, Carol A Langford, Raj Sindwani
BACKGROUND: Granulomatosis with polyangiitis (GPA) (Wegener granulomatosis) frequently presents in the head and neck, and the sinonasal cavity is among the most common areas affected. Although the clinical findings, histologic appearance, and laboratory workup have been described, characteristic findings and the distribution of disease on sinonasal imaging are not well established. The appropriate imaging modality to evaluate for sinonasal involvement is also unclear. OBJECTIVE: To describe the imaging characteristics, distribution, and location of sinonasal pathology in patients with GPA as noted on computed tomography and magnetic resonance imaging modalities...
January 1, 2017: American Journal of Rhinology & Allergy
Shino Shimizu, Ichiro Tojima, Kumiko Takezawa, Koji Matsumoto, Hideaki Kouzaki, Takeshi Shimizu
BACKGROUND: Nasal epithelial cells and infiltrating eosinophils express tissue factor, and high thrombin activity and excess fibrin deposition are found in nasal secretion and in nasal polyp from patients with chronic rhinosinusitis with nasal polyp (CRSwNP). Activated coagulation factors play important roles not only in thrombosis but also in inflammation through interaction with protease-activated receptors (PAR). However, little is known about the effects of activated coagulation factors on the release of cytokines and extracellular matrix from nasal polyp fibroblasts (NPF)...
January 1, 2017: American Journal of Rhinology & Allergy
Christopher D Brook, Jacob E Kuperstock, Samuel J Rubin, Matthew W Ryan, Michael P Platt
BACKGROUND: The relationship between allergic sensitization and radiographic sinus inflammation remains unclear. OBJECTIVES: To determine whether specific allergen sensitization is correlated with sinonasal radiographic opacification. METHODS: Patients with chronic sinonasal symptoms were selected and included if they had allergy testing and a computed tomography (CT) of the paranasal sinuses. Data regarding demographic characteristics, in vitro allergy test results, and comorbidities were collected...
January 1, 2017: American Journal of Rhinology & Allergy
Zhenxiao Huang, Jayakar V Nayak, Yan Sun, Qian Huang, Bing Zhou
BACKGROUND: Analysis of recent research indicated that T-helper cells may play an important role in the pathogenesis of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). OBJECTIVE: The purpose of this study was to investigate the peripheral blood Th1 and Th2 cells and eosinophil population in patients with CRS. METHODS: Peripheral blood samples were obtained from nine nonatopic controls, 37 patients with CRSsNP, and 66 patients with CRSwNP...
January 1, 2017: American Journal of Rhinology & Allergy
Fausto Yoshio Matsumoto, Tessa Rachel Tranquillini Gonçalves, Dirceu Solé, Gustavo Falbo Wandalsen
BACKGROUND: Currently, the diagnosis of allergic rhinitis (AR) is arrived at predominantly by a clinical history and by systemic sensitization tests, but specific nasal provocation tests (NPT) may establish a better direct correlation between etiologic surveyed allergens and nasal symptoms. OBJECTIVES: To standardize the specific NPT with one of the most important house-dust mites, Dermatophagoides pteronyssinus, monitored by acoustic rhinometry, in children and adolescents, and propose a simplified specific NPT to improve its clinical applicability as a diagnostic tool...
January 1, 2017: American Journal of Rhinology & Allergy
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