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Diabetology & Metabolic Syndrome

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https://www.readbyqxmd.com/read/28546831/effect-of-variable-antidiabetic-treatments-strategy-on-oxidative-stress-markers-in-obese-patients-with-t2dm
#1
Abeer A ALrefai, Alsayed M Alsalamony, Sameer H Fatani, Hala F M Kamel
AIM: To evaluate the effect of different anti-diabetic treatment strategy on oxidative stress markers in patients with type 2 diabetes mellitus (T2DM). SUBJECT AND METHODS: A total of 93 patients with T2DM treated with metformin (G1 = 25), OHA (G2 = 22), OA and insulin (G3 = 26) and insulin alone (G4 = 20). In all patients, lipid profile and glycemic indices were assessed using routine laboratory tests. MDA and Oxidized LDL were assessed using commercially available ELISA kits...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28539979/association-of-metabolic-syndrome-and-electrocardiographic-markers-of-subclinical-cardiovascular-disease
#2
Theodora W Elffers, Renée de Mutsert, Hildo J Lamb, Arie C Maan, Peter W Macfarlane, Ko Willems van Dijk, Frits R Rosendaal, J Wouter Jukema, Stella Trompet
BACKGROUND: The metabolic syndrome (MetS) and its components are well-established risk factors for cardiovascular diseases (CVD). It is inconclusive whether MetS and MetS score are associated with electrocardiographic markers of subclinical CVD, therefore we investigated this in a population without pre-existing CVD. METHODS: We performed a cross-sectional analysis in the Netherlands Epidemiology of Obesity study, a population-based cohort including 6671 participants aged 45-65...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28533821/association-of-the-polymorphism-in-nucb2-gene-and-the-risk-of-type-2-diabetes
#3
Chunyu Wang, Yulun Wang, Wenchao Hu
BACKGROUND: Nesfatin-1, originating from its precursor protein called nucleobindin 2 (NUCB2), plays an important role in glucose metabolism and diabetes. The aim of this study is to examine the association of the c.1012C>G (rs757081) polymorphism of NUCB2 gene with the presence of T2DM. METHODS: This study was performed in a population of 396 patients with T2DM and 196 healthy subjects. The c.1012C>G polymorphism of NUCB2 gene was determined using polymerase chain reaction and sequencing method...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28529547/basal-hyperinsulinemia-beyond-a-threshold-predicts-major-adverse-cardiac-events-at-1-year-after-coronary-angiogram-in-type-2-diabetes-mellitus-a-retrospective-cohort-study
#4
Mukund Srinivasan, Padmanabh Kamath, Narayan Bhat, Narasimha Pai, Rajesh Bhat, Tejas Shah, Poornima Manjrekar, Chakrapani Mahabala
BACKGROUND: There is a substantial reduction in cardiovascular related morbidity and mortality in the general population attributed to improved treatment of cardiac risk factors and disease, the same magnitude of benefit has not been observed in those with diabetes mellitus. The aim of the present study was to evaluate factors associated with the cardiac outcome at 1 year after coronary angiogram in patients with type 2 diabetes mellitus and to compare the outcomes with nondiabetics. METHODS: A retrospective cohort study was carried out in subjects who underwent coronary angiogram for an evaluation of CAD, with follow-up data available for period of 12 months...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28529546/disease-management-programs-for-patients-with-type-2-diabetes-mellitus-in-germany-a-longitudinal-population-based-descriptive-study
#5
Michael Mehring, Ewan Donnachie, Florian Cornelius Bonke, Christoph Werner, Antonius Schneider
BACKGROUND: The primary aim of the disease management program (DMP) for patients with diabetes mellitus type 2 is to improve the quality of health care and the treatment process. 12 years after its introduction in Germany, there is still no consensus as to whether DMP has been effective in reaching these goals. METHODS: A retrospective longitudinal population-based study between 2004 and 2015 were conducted to evaluate the DMP for type 2 diabetes in Bavaria using routinely collected patient medical records hold from the National Association of Statutory Health Insurance Physicians of Bavaria...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28515792/mesenchymal-stem-cell-therapy-in-type-2-diabetes-mellitus
#6
REVIEW
Li Zang, Haojie Hao, Jiejie Liu, Yijun Li, Weidong Han, Yiming Mu
Type 2 diabetes mellitus (T2DM), which is characterized by the combination of relative insulin deficiency and insulin resistance, cannot be reversed with existing therapeutic strategies. Transplantation of insulin-producing cells (IPCs) was once thought to be the most promising strategy for treating diabetes, but the pace from the laboratory to clinical application has been obstructed due to its drawbacks. Mesenchymal stem cells (MSCs) harbor differentiation potential, immunosuppressive properties, and anti-inflammatory effects, and they are considered an ideal candidate cell type for treatment of DM...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28515791/vildagliptin-has-the-same-safety-profile-as-a-sulfonylurea-on-bone-metabolism-and-bone-mineral-density-in-post-menopausal-women-with-type-2-diabetes-a-randomized-controlled-trial
#7
Andre Gustavo Daher Vianna, Claudio Silva de Lacerda, Luciana Muniz Pechmann, Michelle Garcia Polesel, Emerson Cestari Marino, Victoria Zeghbi Cochenski Borba, Fellype de Carvalho Barreto
BACKGROUND: Several antidiabetic therapies affect bone metabolism. Sulfonylureas have the lowest impact on bone among oral antidiabetics. The objective of this study is to compare the effects of vildagliptin and gliclazide modified release (MR) on bone turnover markers (BTMs) and bone mineral density (BMD) in postmenopausal women with uncontrolled type 2 diabetes (T2D). METHODS: Forty-two postmenopausal women with uncontrolled T2D were randomly allocated into vildagliptin or gliclazide MR (control) groups...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28507609/depression-and-alexithymia-on-weight-perception-in-patients-with-metabolic-syndrome-and-type-2-diabetes
#8
Maria Cristina de Oliveira Regina, Marcos Antonio Tambascia
BACKGROUND: Obesity's increasing follows decreased perception of weight status in obese persons, mainly female, undergoing age-related changes. OBJECTIVE: To study weight perception and psychological alterations associated to MS and T2DM. METHODS: 200 patients selected from Metabolic Syndrome Outpatient Clinic of University of Campinas. Instruments: Beck Depression and Beck Anxiety Inventories', Toronto Alexithymia Scale-26s, questionnaire and data from reports...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28507608/roles-of-fasting-and-postprandial-blood-glucose-in-the-effect-of-type-2-diabetes-on-central-arterial-stiffness-a-5-year-prospective-community-based-analysis
#9
Shihui Fu, Wenji Chen, Leiming Luo, Ping Ye
BACKGROUND: Cardiovascular disease constitutes a major challenge for the health of community-dwelling population, it is essential to delay the development of atherosclerosis. However, long-term prospective studies analyzing the effect of type 2 diabetes (T2D) on central arterial stiffness are lacking, and roles of fasting and postprandial blood glucose (FBG and PBG) in this effect are controversial. Purpose of the current analysis was to investigate the effect of T2D on central arterial stiffness during the 5 years of follow-up, and explore whether both FBG and PBG were determinants of this effect in Chinese community-dwelling population...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28507607/gene-variants-in-the-fto-gene-are-associated-with-adiponectin-and-tnf-alpha-levels-in-gestational-diabetes-mellitus
#10
Renata Saucedo, Jorge Valencia, Claudia Gutierrez, Lourdes Basurto, Marcelino Hernandez, Edgardo Puello, Guadalupe Rico, Gloria Vega, Arturo Zarate
BACKGROUND: Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators of insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha (TNF-alpha), compared with healthy pregnant controls...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28484521/urinary-podocyte-associated-mrna-levels-correlate-with-proximal-tubule-dysfunction-in-early-diabetic-nephropathy-of-type-2-diabetes-mellitus
#11
Ligia Petrica, Sorin Ursoniu, Florica Gadalean, Adrian Vlad, Gheorghe Gluhovschi, Victor Dumitrascu, Daliborca Vlad, Cristina Gluhovschi, Silvia Velciov, Flaviu Bob, Petru Matusz, Oana Milas, Alina Secara, Anca Simulescu, Roxana Popescu
AIM: The study assessed mRNA expression of podocyte-associated molecules in urinary sediments of patients with type 2 diabetes mellitus (DM) in relation to urinary podocytes, biomarkers of podocyte injury and of proximal tubule (PT) dysfunction. METHODS: A total of 76 patients with type 2 DM and 20 healthy subjects were enrolled in a cross-sectional study, and assessed concerning urinary podocytes, urinary mRNA of podocyte-associated genes, urinary biomarkers of podocyte damage and of PT dysfunction...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28473873/high-awareness-of-diabetes-in-the-health-care-system-in-greenland-measured-as-a-proportion-of-population-tested-with-glycated-haemoglobin-within-2%C3%A2-years
#12
Michael Lynge Pedersen
BACKGROUND: Sixty years ago diabetes was almost non-existent in Greenland and until the beginning of this century awareness of diabetes was quite minimal. A high prevalence of undiagnosed diabetes has been reported in repeated population surveys. Increased focus on diabetes has been made a priority within the health care system since 2008, and in 2010 glycated haemoglobin was introduced as a diagnostic tool to further facilitate the diagnosis of diabetes. OBJECTIVE: The aim of this study was to estimate the age and gender specific use of glycated haemoglobin in 2014 and 2015, as an indicator of diagnostic activity and awareness of diabetes, and to estimate the prevalence of diagnosed pre-diabetes and diabetes among adults in Greenland aged 20-79 years of age...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28473872/inpatient-screening-for-albuminuria-and-retinopathy-to-predict-long-term-mortality-in-type-2-diabetic-patients-a-retrospective-cohort-study
#13
Ya-Mei Hsieh, Wen-Jane Lee, Wayne H-H Sheu, Yu-Hsuan Li, Shih-Yi Lin, I-Te Lee
BACKGROUND: There is a high hospitalization rate for diabetic patients. Since retinopathy and albuminuria are both important manifestations of microvascular disease in diabetes, our aim was to investigate the effect of retinopathy and albuminuria on long-term mortality in type 2 diabetic inpatients through this observational cohort study. METHODS: Type 2 diabetic inpatients given a primary diagnosis of poor glucose control were consecutively enrolled during their hospitalization periods...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28469712/characteristics-and-cardiovascular-complications-of-a-large-cohort-of-adults-diagnosed-with-type-2-diabetes%C3%A2-45%C3%A2-years
#14
Barbara Deconinck, Chantal Mathieu, Katrien Benhalima
BACKGROUND: The aim was to evaluate the characteristics and cardiovascular complications of a large Belgian cohort of adults diagnosed with type 2 diabetes (T2DM) <45 years. METHODS: Retrospective analysis of 886 patients diagnosed with T2DM <45 years and 933 T2DM patients diagnosed at the age between 60 and 70 years. To compare variables between groups, the independent t test or paired t test was used for normally distributed continuous variables, the Mann-Whitney's U-test for non-normally distributed continuous variables and the Chi squared test or McNemar test for categorical variables...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28450900/dipeptidyl-peptidase-4-levels-are-increased-and-partially-related-to-body-fat-distribution-in-patients-with-familial-partial-lipodystrophy-type-2
#15
Cynthia Melissa Valerio, Juliana Severo de Almeida, Rodrigo Oliveira Moreira, Luiza Barreto S Aguiar, Priscila O Siciliano, Denise P Carvalho, Amelio F Godoy-Matos
BACKGROUND: Dipeptidyl peptidase-4 (DDP4) is an enzyme responsible for glucagon-like peptide-1 inactivation and plays an important role in glucose metabolism. OBJECTIVE: The aim of this study was to evaluate DPP4 levels in patients with familial partial lipodystrophy type 2 (FPLD2) and correlate it with body fat distribution. METHODS: Fourteen patients with FPLD2 were selected to participate in this study and matched to a healthy control group (n = 8)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28435446/cardiovascular-risk-assessment-in-patients-with-diabetes
#16
REVIEW
Marcello Casaccia Bertoluci, Viviane Zorzanelli Rocha
Although patients with diabetes have 2 to 4 times increased risk of cardiovascular morbidity and mortality than individuals without diabetes, recent studies indicate that a significant part of patients are in a lower cardiovascular risk category. Men younger than 35 years, women younger than 45 years, patients with diabetes duration of less than 10 years without other risk factors have a much lower risk than patients who have traditional cardiovascular risk factors, and subclinical or established coronary artery disease (CAD)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28435445/cardiometabolic-risk-factors-metabolic-syndrome-and-pre-diabetes-in-adolescents-in-the-sierra-region-of-ecuador
#17
Sharon L Casapulla, Cheryl A Howe, Gabriela Rosero Mora, Darlene Berryman, Mario J Grijalva, Edgar W Rojas, Masato Nakazawa, Jay H Shubrook
BACKGROUND: Excess weight (overweight and obesity) is the major modifiable risk factor for type 2 diabetes mellitus (T2DM) and other non-communicable diseases. However, excess weight may not be as predictive of diabetes risk as once thought. While excess weight and other obesity-related non-communicable diseases are of growing concern in low-middle income countries in Latin America, there is limited research on risk factors associated with T2DM in adolescents. This study investigated prevalence of overweight, obesity, prediabetes, diabetes and metabolic syndrome in adolescents in Ecuador...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28413455/letter-to-editor-the-waist-circumference-adjusted-associations-between-hyperuricemia-and-other-lifestyle-related-diseases-methodological-issues-in-cross-sectional-study
#18
Shiva Mansouri Hanis, Fatemeh Khosravi Shadmani, Kamyar Mansori
No abstract text is available yet for this article.
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28405227/impact-of-menopause-and-diabetes-on-atherogenic-lipid-profile-is-it-worth-to-analyse-lipoprotein-subfractions-to-assess-cardiovascular-risk-in-women
#19
REVIEW
Marília Izar Helfenstein Fonseca, Isis Tande da Silva, Sandra Roberta G Ferreira
Cardiovascular disease is the leading cause of death in women at advanced age, who are affected a decade later compared to men. Cardiovascular risk factors in women are not properly investigated nor treated and events are frequently lethal. Both menopause and type 2 diabetes substantially increase cardiovascular risk in the female sex, promoting modifications on lipid metabolism and circulating lipoproteins. Lipoprotein subfractions suffer a shift after menopause towards a more atherogenic lipid profile, consisted of hypertriglyceridemia, lower levels of both total high density lipoprotein (HDL) and its subfraction HDL2, but also higher levels of HDL3 and small low-density lipoprotein particles...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28396699/can-the-onset-of-heart-failure-be-delayed-by-treating-diabetic-cardiomyopathy
#20
REVIEW
Anna Marcinkiewicz, Stanisław Ostrowski, Józef Drzewoski
The pathophysiology of diabetic cardiomyopathy (DC) is not fully understood. This frequently undiagnosed complication of chronic hyperglycemia leads to heart failure (HF). However, it is suggested that an appropriate metabolic control of diabetes at an early stage of this deleterious disease, is able to inhibit the development and progression of DC to HF. Recently, it has been postulated that myocardial ischaemia plays an important role in the development of this pathology. Results of the antianginal pharmacological treatment and revascularization are unsatisfactory and reveal a gap in our knowledge and current approaches to treating DC...
2017: Diabetology & Metabolic Syndrome
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