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Diabetology & Metabolic Syndrome

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https://www.readbyqxmd.com/read/29760789/higher-cardiometabolic-risk-in-idiopathic-versus-autoimmune-type-1-diabetes-a-retrospective-analysis
#1
Valentina Guarnotta, Enrica Vigneri, Giuseppe Pillitteri, Alessandro Ciresi, Giuseppe Pizzolanti, Carla Giordano
Background: Idiopathic type 1 diabetes mellitus (IDM) is characterized by an onset with insulinopenia and ketoacidosis with negative β-cell autoimmunity markers and lack of association with HLA. The aim of the study is to compare the clinical and metabolic parameters, the macro and microvascular complications, the adipose tissue dysfunction and the insulin secretion and sensitivity indexes in patients with IDM and autoimmune type 1 diabetes mellitus (ADM) at clinical onset. Methods: Thirty patients with IDM and 30 with ADM, matched for age and gender, were retrospectively analyzed...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29760788/the-effectiveness-of-stress-management-training-on-blood-glucose-control-in-patients-with-type-2-diabetes
#2
Fereshteh Zamani-Alavijeh, Marzieh Araban, Hamid Reza Koohestani, Mahmood Karimy
Background: Type 2 diabetes is a chronic disease that is expanding at an alarming rate in the world. Research on individuals with type 2 diabetes showed that stressful life events cause problems in the effective management and control of diabetes. This study aimed at investigating the effect of a stress management intervention on blood glucose control in individuals with type 2 diabetes referred to Zarandeh clinic, Iran. Methods: In this experimental study, 230 individuals with type 2 diabetes (179 female and 51 male) were enrolled and assigned to experimental (n = 115) and control (n = 115) groups...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29755591/improved-insulin-sensitivity-and-lower-postprandial-triglyceride-concentrations-after-cold-pressed-turnip-rapeseed-oil-compared-to-cream-in-patients-with-metabolic-syndrome
#3
Harri Juhani Saarinen, Sari Husgafvel, Hanna Pohjantähti-Maaroos, Marja Wallenius, Ari Palomäki
Background: The aim of this study was to compare acute effects of turnip rapeseed oil rich with mono- and polyunsaturated fatty acids and cream on postprandial triglyceride levels and post-glucose load measures of insulin sensitivity in population of men with metabolic syndrome. Methods: This open-label balanced crossover study included 37 men with metabolic syndrome. They underwent an oral glucose-fat tolerance test where they ingested 75 g of glucose with either 240 mL of cream or 84 mL of turnip rapeseed oil depending on the study arm...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29736187/-tcf7l2-correlation-in-both-insulin-secretion-and-postprandial-insulin-sensitivity
#4
Mari Cassol Ferreira, Maria Elizabeth Rossi da Silva, Rosa Tsuneshiro Fukui, Maria do Carmo Arruda-Marques, Rosa Ferreira Dos Santos
Background: The TCF7L2 rs7903146 variant is strongly associated with type 2 diabetes mellitus (T2DM). However, the mechanisms involved in this association remain unknown and may include extrapancreatic effects. The aim of this study was to perform a metabolic characterization of T2DM patients with and without the TCF7L2 rs7903146 risk T allele and analyze some influences of the TCF7L2 genotype on glucose metabolism. Methods: Patients with T2DM ( n  = 162) were genotyped for the TCF7L2 rs7903146 single nucleotide polymorphism...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29713389/establishing-post-mortem-criteria-for-the-metabolic-syndrome-an-autopsy-based-cross-sectional-study
#5
Martin Roest Christensen, Anne Bugge, Mariam Elmegaard Malik, Jørgen Lange Thomsen, Niels Lynnerup, Jørgen Rungby, Jytte Banner
Background: Individuals who suffer from mental illness are more prone to obesity and related co-morbidities, including the metabolic syndrome. Autopsies provide an outstanding platform for the macroscopic, microscopic and molecular-biological investigation of diseases. Autopsy-based findings may assist in the investigation of the metabolic syndrome. To utilise the vast information that an autopsy encompasses to elucidate the pathophysiology behind the syndrome further, we aimed to both develop and evaluate a method for the post mortem definition of the metabolic syndrome...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29713388/post-operative-stress-hyperglycemia-is-a-predictor-of-mortality-in-liver-transplantation
#6
Elena Giráldez, Evaristo Varo, Ipek Guler, Carmen Cadarso-Suarez, Santiago Tomé, Patricia Barral, Antonio Garrote, Francisco Gude
Background: A significant association is known between increased glycaemic variability and mortality in critical patients. To ascertain whether glycaemic profiles during the first week after liver transplantation might be associated with long-term mortality in these patients, by analysing whether diabetic status modified this relationship. Method: Observational long-term survival study includes 642 subjects undergoing liver transplantation from July 1994 to July 2011...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29713387/metabolic-syndrome-among-overweight-and-obese-adults-in-palestinian-refugee-camps
#7
Basma Damiri, Mohammed S Abualsoud, Amjad M Samara, Sakhaa K Salameh
Background: Metabolic syndrome (MetS) is one of the main reasons for elevated cardiovascular morbidity and mortality worldwide. Obese and overweight individuals are at high risk of developing these chronic diseases. The aim of this study was to characterize and establish sex-adjusted prevalence of metabolic syndrome and its components. Methods: A cross-sectional study was conducted in 2015, 689 (329 men and 360 women) aged 18-65 years from three refugee camps in the West Bank...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29713386/hookah-smoking-is-strongly-associated-with-diabetes-mellitus-metabolic-syndrome-and-obesity-a-population-based-study
#8
Sara Saffar Soflaei, Susan Darroudi, Maryam Tayefi, Abolfazl Nosrati Tirkani, Mohsen Moohebati, Mahmoud Ebrahimi, Habibollah Esmaily, Seyed Mohammad Reza Parizadeh, Ali Reza Heidari-Bakavoli, Gordon A Ferns, Majid Ghayour-Mobarhan
Objectives: The adverse effects of cigarette smoking have been widely studied before, whilst the effects of hookah smoking has received less attention, although it is a common habit in the Middle East. Here we have investigated the effects of cigarette and hookah smoking on biochemical characteristics in a representative population sample derived from the Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study, from Northeastern Iran. Study design: A total of 9840 subjects from the MASHAD population study were allocated to five groups; non-smokers (6742), ex-smokers (976), cigarette smokers (864), hookah smokers (1067), concomitant cigarette and hookah smokers (41)...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29686737/chikungunya-and-diabetes-what-do-we-know
#9
REVIEW
Francisca Kalline de Almeida Barreto, Renan Magalhães Montenegro, Virginia Oliveira Fernandes, Rhaquel Oliveira, Lívia Aline de Araújo Batista, Akhtar Hussain, Luciano Pamplona de Góes Cavalcanti
Background: Chikungunya (CHIK) is a viral disease transmitted by mosquitoes. The first cases in Brazil were confirmed in 2014. Between 2016 and 2017, over 300,000 cases were identified during this period, with nearly 300 deaths. The clinical manifestations, pathogenesis and risk factors for occurrence of severe cases are not yet well understood, although it is known that the severity of the cases is associated with the presence of comorbidities, especially diabetes mellitus (DM). Objective: To review the medical literature for the associations between DM and CHIK and to understand the potential impact on metabolic state and its complications...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29682007/possible-neuroprotective-role-of-p2x2-in-the-retina-of-diabetic-rats
#10
Jorge E Mancini, Gustavo Ortiz, Constanza Potilinstki, Juan P Salica, Emiliano S Lopez, J Oscar Croxatto, Juan E Gallo
Background: Purinergic receptors are expressed in different tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major activator of P2 receptors. In diabetes, there is a constant ATP production and this rise of ATP leads to a persistent activation of purinergic receptors. Antagonists of these receptors are used to evaluate their inhibition effects. Recently, the P2X2 has been reported to have a neuroprotective role...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29651307/effectiveness-of-gliclazide-mr-60-mg-in-the-management-of-type-2-diabetes-analyses-from-the-easydia-trial
#11
Lawrence A Leiter, Marina V Shestakova, Ilhan Satman
Background: Although the number of antihyperglycemic agents has expanded significantly, sulfonylureas (in particular gliclazide) remain an important option because of a variety of patient and health system factors. The large, real world, observational, and international EASYDia trial evaluated the effectiveness of gliclazide modified release (MR) 60 mg in individuals with type 2 diabetes with a broad range of diabetes history, body mass index (BMI) and background antihyperglycemic treatment...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29651306/association-of-mean-platelet-volume-with-incident-type-2-diabetes-mellitus-risk-the-dongfeng-tongji-cohort-study
#12
Zhaoyang Li, Jing Wang, Xu Han, Jing Yuan, Huan Guo, Xiaomin Zhang, Dan Zheng, Yuhan Tang, Handong Yang, Meian He
Background: Most of prior studies to demonstrate the association between mean platelet volume (MPV) and type 2 diabetes mellitus (T2DM) risk were cross-sectional design with inconsistent results. In the present prospective cohort study, we aimed to explore the relationship between MPV and incident T2DM risk among a middle-aged and older Chinese population. Methods: This prospective study included 14,009 individuals derived from the Dongfeng-Tongji cohort which was launched in 2008...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29643940/the-impact-of-a-disease-management-programme-for-type-2-diabetes-on-health-related-quality-of-life-multilevel-analysis-of-a-cluster-randomised-controlled-trial
#13
Sigrid Panisch, Tim Johansson, Maria Flamm, Henrike Winkler, Raimund Weitgasser, Andreas C Sönnichsen
Background: Type 2 diabetes is a chronic disease associated with poorer health outcomes and decreased health related quality of life (HRQoL). The aim of this analysis was to explore the impact of a disease management programme (DMP) in type 2 diabetes on HRQoL. A multilevel model was used to explain the variation in EQ-VAS. Methods: A cluster-randomized controlled trial-analysis of the secondary endpoint HRQoL. Our study population were general practitioners and patients in the province of Salzburg...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29636825/combination-of-basal-insulin-and-glp-1-receptor-agonist-is-this-the-end-of-basal-insulin-alone-in-the-treatment-of-type-2-diabetes
#14
REVIEW
Rodrigo Oliveira Moreira, Roberta Cobas, Raquel C Lopes Assis Coelho
Glycemic control has been considered a major therapeutic goal within the scope of diabetes management, as supported by robust observational and experimental evidence. However, the coexistence of micro and macrovascular disease is associated with the highest cardiovascular risks which highlights the importance that pharmacological treatment of type 2 diabetes mellitus provides not only glycemic control, but also cardiovascular safety. Basal insulin is a highly effective treatment in reducing fasting blood glucose, but it is associated with considerable risk of hypoglycemia and weight gain...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29632617/sarcopenia-a-chronic-complication-of-type-2-diabetes-mellitus
#15
Heloísa Trierweiler, Gabrielle Kisielewicz, Thaísa Hoffmann Jonasson, Ricardo Rasmussen Petterle, Carolina Aguiar Moreira, Victória Zeghbi Cochenski Borba
Background: Diabetics are at increased risk for impaired mobility and strength, frequently related to the disease control. Sarcopenia is the reduction of muscle mass associated with the decrease in muscle strength and/or performance, resulting in worse morbidity in chronic diseases. Methods: The objectives of this paper was to assess the prevalence of sarcopenia in patients with type 2 diabetes mellitus (T2DM) and determine its association with diabetes characteristics, progression, and complications, as well as changes in bone mineral density...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29619091/dynamic-development-of-metabolic-syndrome-and-its-risk-prediction-in-chinese-population-a-longitudinal-study-using-markov-model
#16
Xiaoxian Jia, Qicai Chen, Peipei Wu, Meng Liu, Xiaoxiao Chen, Juan Xiao, Lili Chen, Pengpeng Zhang, Shumei Wang
Background: With the increasing prevalence of metabolic syndrome (MS), there is a need to track and predict the development of MS. In this study, we established a Markov model to explore the natural history and predict the risk of MS. Methods: A total of 21,777 Chinese individuals who had at least two consecutive health check-ups between 2010 and 2015 were studied. MS was defined using the Chinese Diabetes Society criteria. Twelve metabolic abnormal states (the no component state, four isolated component states, six 2-component states, and the MS state) were contained in each Markov chain...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29610581/bridging-glycated-hemoglobin-with-quality-of-life-and-health-state-a-randomized-case-control-study-among-type-2-diabetes-patients
#17
Syed Wasif Gillani, Irfan Altaf Ansari, Hisham A Zaghloul, Mohi Iqbal Mohammad Abdul, Syed Azhar Syed Sulaiman, Mirza R Baig
Background: The aim of this study was to explore the predictors of QOL and health state and examine the relationship with glycemic control among type 2 diabetes mellitus (T2DM) patients. Methods: A randomized cross-sectional case-control study was conducted among n = 600 T2DM patients of Malaysia. Study population was distributed into three groups as: controls: patients with HbA1c ≤ 7 (n = 199), cases arm 1: with HbA1c 7-7.9 (n = 204) and cases arm 2 (n = 197): with HbA1c ≥ 8 consecutively last 3 times...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29599823/regional-differences-in-the-prevalence-of-diabetic-retinopathy-a-multi-center-study-in-brazil
#18
Karla Rezende Guerra Drummond, Fernando Korn Malerbi, Paulo Henrique Morales, Tessa Cerqueira Lemos Mattos, André Araújo Pinheiro, Felipe Mallmann, Ricardo Vessoni Perez, Franz Schubert Lopes Leal, Laura Gomes Nunes de Melo, Marília Brito Gomes
Background: Diabetic retinopathy has a significant impact in every healthcare system. Despite that fact, there are few accurate estimates in the prevalence of DR in Brazil's different geographic regions, particularly proliferative DR and diabetic macular edema. This study aims to determine the prevalence of diabetic retinopathy in Brazil's five continental regions and its determinant factors. Methods: This multi center, cross-sectional, observational study, conducted between August 2011 and December 2014, included patients with type 1 diabetes from the 5 Brazilian geographic regions (South, Southeast, North, Northeast and Midwest)...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29568334/serum-uric-acid-and-renal-function-in-patients-with-type-1-diabetes-a-nationwide-study-in-brazil
#19
Marcela Haas Pizarro, Deborah Conte Santos, Bianca Senger Vasconcelos Barros, Laura Gomes Nunes de Melo, Marilia Brito Gomes
Background: Diabetes nephropathy is a microvascular complication associated with high morbidity and mortality in patients with type 1 diabetes, and its pathogenesis is not fully understood. Our aim was to evaluate the association between levels of serum uric acid and renal function assessed by glomerular filtration rate (GFR) and albuminuria in patients with type 1 diabetes. Methods: This is a multicenter, cross-sectional, observational study with 1686 patients, conducted between August 2011 and August 2014 in 14 public clinics from ten Brazilian cities...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29568333/relationship-between-a-body-shape-index-absi-and-body-composition-in-obese-patients-with-type-2-diabetes
#20
Fernando Gomez-Peralta, Cristina Abreu, Margarita Cruz-Bravo, Elvira Alcarria, Gala Gutierrez-Buey, Nir Y Krakauer, Jesse C Krakauer
Background: Obesity is known to be related to the development of type 2 diabetes mellitus (T2D). The most commonly used anthropometric indicator (body mass index [BMI]) presents several limitations such as the lack of possibility to distinguish adipose tissue distribution. Thus, this study examines the suitability of a body shape index (ABSI) for prediction of body composition and sarcopenic obesity in obese or overweight T2D subjects. Methods: Cross-sectional study in 199 overweight/obese T2D adults...
2018: Diabetology & Metabolic Syndrome
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