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Diabetology & Metabolic Syndrome

Mayada Issa, Fahad Alqahtani, Chalak Berzingi, Mohammad Al-Hajji, Tatiana Busu, Mohamad Alkhouli
Background: Acute hyperglycemia is associated with worse outcomes in diabetic patients admitted with ST-elevation myocardial infarction (STEMI). However, the impact of full-scale decompensated diabetes on STEMI outcomes has not been investigated. Methods: We utilized the national inpatient sample (2003-2014) to identify adult diabetic patients admitted with STEMI. We defined decompensated diabetes as the presence of diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar state (HHS)...
2018: Diabetology & Metabolic Syndrome
Sung-Sheng Tsai, Yun-Yi Chu, Szu-Tah Chen, Pao-Hsien Chu
Background: The reported outcomes of the metabolic syndrome (MetS), containing atherosclerotic cardiovascular disease and diabetes, vary according to the definitions used. This study was designed to compare the performance of the Adult Treatment Panel III/American Heart Association/National Heart, Lung, and Blood Institute (ATP III/AHA/NHLBI) and International Diabetes Federation (IDF) criteria for the risks of atherosclerosis and diabetes. Methods: We sifted subjects from a self-paid Health examination program from 1999 to 2015 in this cross-sectional population-based study...
2018: Diabetology & Metabolic Syndrome
Ryuichi Kawamoto, Daisuke Ninomiya, Asuka Kikuchi, Taichi Akase, Teru Kumagi
Background: Elevated serum uric acid (SUA) levels are associated with glucose control. However, whether baseline and changes in SUA predict long-term follow-up glucose control [e.g., glycated hemoglobin (HbA1c)] remains unclear. Methods: The subjects comprised 393 women aged 71 ± 8 years and 279 men aged 71 ± 10 years from a rural village. We have identified participants who underwent a similar examination 11 years prior, and subjects were divided into four groups based on the tertiles of baseline and changes in SUA, and examined the relationship between baseline and changes in SUA, and glucose control evaluated by follow-up HbA1c after 11-years...
2018: Diabetology & Metabolic Syndrome
Adriana Cezaretto, Claudia Kimie Suemoto, Isabela Bensenor, Paulo A Lotufo, Bianca de Almeida-Pititto, Sandra R G Ferreira
Background: Adiponectin is an insulin-sensitizer adipocytokine endowed with neuroprotective actions. Whether adiponectin regulates neuronal functioning toward delaying cognitive decline independently of the glucose metabolism disturbance has been poorly explored. This study evaluated if the performance in cognitive tests was associated with adiponectin levels prior the development of type 2 diabetes in middle-aged individuals. Methods: A sample of 938 non-diabetic participants of ELSA had their cognitive function assessed by the CERAD delayed word recall test, the verbal fluency test and the trail making test...
2018: Diabetology & Metabolic Syndrome
Juhyun Song, So Ra Yoon, Oh Yoen Kim
Background: Low adiponectin levels are associated with increased insulin resistance (IR) and arterial stiffness in hypertensive patients, but higher adiponectin levels are also found in heart failure patients. This discrepancy has not been fully resolved, but it may be related to the adiponectin gene ( ADIPOQ ) which regulates adiponectin production. We aimed to investigate whether the relationship between adiponectin and arterial stiffness is associated with ADIPOQ rs1501299 G/T polymorphism in nondiabetic Korean men...
2018: Diabetology & Metabolic Syndrome
Valeria Calcaterra, Jonathan P Winickoff, Catherine Klersy, Luca Maria Schiano, Rossella Bazzano, Chiara Montalbano, Valeria Musella, Corrado Regalbuto, Daniela Larizza, Hellas Cena
Background: To evaluate the relationship between smoking and metabolic parameters in patients affected by type 1 diabetes (T1D). Patients and methods: We enrolled 104 children and young adults (50 females and 54 males) with T1D (aged 16.4 ± 8.6 years). The subjects were divided into three groups according to their smoking habits: no smoking (NS), passive smoking (PS), active smoking (AS). The physical examination of the participants included nutritional status assessment by anthropometry and pubertal stage according to Marshall and Tanner as well as blood pressure measurement...
2018: Diabetology & Metabolic Syndrome
Roya Kelishadi, Ramin Heshmat, Marjan Mansourian, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Zeinab Ahadi, Tahereh Aminaee, Azam Goodarzi, Morteza Mansourian, Mostafa Qorbani, Nafiseh Mozafarian
Objective: This study aims to determine the association of dietary patterns with metabolic syndrome (MetS) and its components in children and adolescents. Methods: This nationwide study was conducted in 2015 among 4200 students aged 7-18 years, who lived in 30 provinces in Iran. The analysis was conducted based on the propensity score using a matched case-control study design. Three dietary patterns were obtained conducting a principal component analysis with a varimax rotation on 16 dietary groups...
2018: Diabetology & Metabolic Syndrome
Qiuyi Ke, Chaogang Chen, Fengyi He, Yongxin Ye, Xinxiu Bai, Li Cai, Min Xia
Background: Epidemiological studies have demonstrated that high total protein intake was related to type 2 diabetes mellitus (T2DM) risks. However, few studies considered the impact of dietary pattern. Objective: We examined the associations between protein intake and T2DM in different dietary patterns. Methods: We used the demographic and dietary information of adults aged 18-75 years from the China Health and Nutrition Survey (2009), consisting of 4113 women and 4580 men...
2018: Diabetology & Metabolic Syndrome
Carlos Gustavo M G Lima, Laercio Joel Franco, Amaury L Dal Fabbro, Edson Z Martinez, João Paulo Botelho Veira-Filho, Alexandre A C M Ventura, Leonardo Prevelato, Antonio Augusto V Cruz
Background: To describe the frequency of diabetic retinopathy (DR) and its associated variables in Brazilian Xavante Indians. Methods: A population-based survey carried out in two Xavante Reservations between 2008 and 2012, included 948 Indians aged 20 years or more, identified 246 individuals with type 2 diabetes. A non-probabilistic cluster sample of 140 diabetic individuals were submitted to ophthalmologic examination. Due to operational conditions and to optimize the field work, only the larger Xavante villages were included...
2018: Diabetology & Metabolic Syndrome
Fariba Raygan, Zohreh Rezavandi, Fereshteh Bahmani, Vahidreza Ostadmohammadi, Mohammad Ali Mansournia, Maryam Tajabadi-Ebrahimi, Shokoofeh Borzabadi, Zatollah Asemi
Background: This study was conducted to evaluate the effects of probiotic supplementation on metabolic profiles in diabetic patients with coronary heart disease (CHD). Methods: This randomized, double-blind, placebo-controlled trial was performed among 60 diabetic patients with CHD, aged 40-85 years at a cardiology clinic in Kashan, Iran, from October 2017 through January 2018. Patients were randomly divided into two groups to take either probiotic supplements (n = 30) or placebo (n = 30) for 12 weeks...
2018: Diabetology & Metabolic Syndrome
Kyoung-Nam Kim, Se-Young Oh, Yun-Chul Hong
Background: Previous evidence regarding the associations between serum calcium concentrations, dietary calcium intake, and type 2 diabetes (T2D) is limited. We investigated the longitudinal associations of serum calcium levels and dietary calcium intake with T2D development. Methods: This study used data from the Ansung-Ansan cohort, a community-based, prospective cohort that was followed up for 10 years. Cox regression models adjusted for potential confounders were used to evaluate the associations of serum calcium levels (mean, 9...
2018: Diabetology & Metabolic Syndrome
Thiane Ristow Cardinal, Alvaro Vigo, Bruce Bartholow Duncan, Sheila Maria Alvim Matos, Maria de Jesus Mendes da Fonseca, Sandhi Maria Barreto, Maria Inês Schmidt
Background: Waist circumference (WC) has been incorporated in the definition of the metabolic syndrome (MetS) but the exact WC cut-off points across populations are not clear. The Joint Interim Statement (JIS) suggested possible cut-offs to different populations and ethnic groups. However, the adequacy of these cut-offs to Brazilian adults has been scarcely investigated. The objective of the study is to evaluate possible WC thresholds to be used in the definition of MetS using data from the Longitudinal Study of Adult Health (ELSA-Brasil), a multicenter cohort study of civil servants (35-74 years old) of six Brazilian cities...
2018: Diabetology & Metabolic Syndrome
Keisuke Sumi, Tsuyoshi Okura, Youhei Fujioka, Masahiko Kato, Takeshi Imamura, Shin-Ichi Taniguchi, Kazuhiro Yamamoto
Background: In mitochondrial diabetes, apoptosis of β-cells caused by mitochondrial stress plays an important role in impaired insulin secretion. Several studies have reported that coenzyme Q10 (CoQ10) has therapeutic effects on mitochondrial diabetes, but no reports have examined the fundamental effectiveness or mechanism of CoQ10 in mitochondrial diabetes. We previously reported in a Japanese article that CoQ10 has protective effects on pancreatic β-cells against mitochondrial stress using mouse pancreatic β-cell line MIN6 and staurosporine (STS)...
2018: Diabetology & Metabolic Syndrome
Séphora Louyse Silva Aquino, Aline Tuane Oliveira da Cunha, Hermilla Torres Pereira, Erika Paula Silva Freitas, Ana Paula Trussardi Fayh, Josivan Gomes Lima, Severina Carla Vieira Cunha Lima, Karine Cavalcanti Maurício Sena-Evangelista, Lucia Fátima Campos Pedrosa
Background: The risk of metabolic syndrome can be influenced by inadequate vitamin D levels, and exposure to sunlight is the main external source of vitamin D. The present study assessed the influence of environmental, biological, and nutritional factors in relation to seasonal 25-hydroxyvitamin D (25OHD) concentration in individuals with metabolic syndrome. Methods: This cross-sectional study enrolled 180 individuals with metabolic syndrome aged between 18 and 80 years...
2018: Diabetology & Metabolic Syndrome
Nahla Khawaja, Jawad Abu-Shennar, Mohammed Saleh, Said S Dahbour, Yousef S Khader, Kamel M Ajlouni
[This corrects the article DOI: 10.1186/s13098-018-0309-6.].
2018: Diabetology & Metabolic Syndrome
Yi Guo, Solomon K Musani, Mario Sims, Thomas A Pearson, Mark D DeBoer, Matthew J Gurka
Background: The severity of the metabolic syndrome (MetS) predicts future coronary heart disease (CHD) and diabetes independent of the individual MetS components. Our aim was to evaluate whether MetS severity conferred additional discrimination to existing scoring systems for cardiovascular disease (CVD) and diabetes risk. Methods: We assessed Cox proportional hazard models of CHD- and diabetes risk among 13,141 participants of the Atherosclerosis Risk in Communities Study and the Jackson Heart Study, using the Framingham Risk Calculator, the American Heart Association's Atherosclerotic CVD calculator, the American Diabetes Association diabetes risk score and an additional diabetes risk score derived from ARIC data...
2018: Diabetology & Metabolic Syndrome
Nguyen Linh Toan, Nguyen Van Hoan, Doan Viet Cuong, Nguyen Viet Dung, Phan The Dung, Ngo Thu Hang, Do Thi Huyen Dieu, Dang Thanh Chung, Ho Anh Son, Pham Xuan Phong, George Binh Lenon, Doan Van De, Hoang Van Tong
Background: Adipokines are involved in the pathogenesis of metabolic disorders including obesity and type 2 diabetes mellitus (T2DM). This study investigates the levels of leptin, resistin, visfatin, secreted frizzled-related protein 5 (SFRP5), monocyte chemoattractant protein-1 (MCP-1) and retinol-binding protein 4 (RBP4) and their correlations with clinical parameters of overweight and T2DM. Methods: We recruited overweight 50 patients with T2DM, 88 non-overweight patients with T2DM, 29 overweight and 100 non-overweight individuals devoid of T2DM for this study...
2018: Diabetology & Metabolic Syndrome
Valentina Guarnotta, Enrica Vigneri, Giuseppe Pillitteri, Alessandro Ciresi, Giuseppe Pizzolanti, Carla Giordano
Background: Idiopathic type 1 diabetes mellitus (IDM) is characterized by an onset with insulinopenia and ketoacidosis with negative β-cell autoimmunity markers and lack of association with HLA. The aim of the study is to compare the clinical and metabolic parameters, the macro and microvascular complications, the adipose tissue dysfunction and the insulin secretion and sensitivity indexes in patients with IDM and autoimmune type 1 diabetes mellitus (ADM) at clinical onset. Methods: Thirty patients with IDM and 30 with ADM, matched for age and gender, were retrospectively analyzed...
2018: Diabetology & Metabolic Syndrome
Fereshteh Zamani-Alavijeh, Marzieh Araban, Hamid Reza Koohestani, Mahmood Karimy
Background: Type 2 diabetes is a chronic disease that is expanding at an alarming rate in the world. Research on individuals with type 2 diabetes showed that stressful life events cause problems in the effective management and control of diabetes. This study aimed at investigating the effect of a stress management intervention on blood glucose control in individuals with type 2 diabetes referred to Zarandeh clinic, Iran. Methods: In this experimental study, 230 individuals with type 2 diabetes (179 female and 51 male) were enrolled and assigned to experimental (n = 115) and control (n = 115) groups...
2018: Diabetology & Metabolic Syndrome
Harri Juhani Saarinen, Sari Husgafvel, Hanna Pohjantähti-Maaroos, Marja Wallenius, Ari Palomäki
Background: The aim of this study was to compare acute effects of turnip rapeseed oil rich with mono- and polyunsaturated fatty acids and cream on postprandial triglyceride levels and post-glucose load measures of insulin sensitivity in population of men with metabolic syndrome. Methods: This open-label balanced crossover study included 37 men with metabolic syndrome. They underwent an oral glucose-fat tolerance test where they ingested 75 g of glucose with either 240 mL of cream or 84 mL of turnip rapeseed oil depending on the study arm...
2018: Diabetology & Metabolic Syndrome
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