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Diabetology & Metabolic Syndrome

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https://www.readbyqxmd.com/read/28794803/translation-and-cultural-adaptation-into-brazilian-culture-of-type-1-diabetes-distress-scale
#1
M S V M Silveira, T G Bovi, P F Oliveira, E J Pavin, L Fisher
BACKGROUND: Diabetes related distress is common in type 1 diabetes patients (T1D). High levels of diabetes distress are related to poor metabolic control. An instrument to evaluate diabetes distress in T1D patients is "type 1 diabetes scale-T1DDS". The aim of this study was to translate and culturally adapt the T1DDS into Brazilian culture. METHODS: T1DDS scale was translated into Portuguese. Back translation was performed and evaluated by a specialists committee...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28785316/early-effects-of-sodium-glucose-co-transporter-2-inhibitors-in-type-2-diabetes-study-based-on-continuous-glucose-monitoring
#2
Keiichi Torimoto, Yosuke Okada, Kenji Koikawa, Yoshiya Tanaka
BACKGROUND: Inhibitors of sodium-glucose co-transporter 2 (SGLT2) have immediate glucose-lowering effects by promoting urinary glucose excretion, without altering insulin level. Only a few studies have evaluated blood glucose dynamics in the early period after administration. The present retrospective study was designed to determine the immediate effects of SGLT2 inhibitors on blood glucose dynamics. METHODS: The study subjects were 24 patients with type 2 diabetes whose blood glucose dynamics were evaluated with continuous glucose monitoring for 1 week before and after initiation of SGLT2 inhibitor therapy...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28770011/interactions-between-antidiabetic-drugs-and-herbs-an-overview-of-mechanisms-of-action-and-clinical-implications
#3
REVIEW
Ramesh C Gupta, Dennis Chang, Srinivas Nammi, Alan Bensoussan, Kellie Bilinski, Basil D Roufogalis
Diabetes is a complex condition with a variety of causes and pathophysiologies. The current single target approach has not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28770010/a-qualitative-study-to-explore-the-perception-and-behavior-of-patients-towards-diabetes-management-with-physical-disability
#4
Syed Wasif Gillani, Syed Azhar Syed Sulaiman, Mohi Iqbal Mohammad Abdul, Sherif Y Saad
BACKGROUND: This study aimed to determine self-monitoring practices, awareness to dietary modifications and barriers to medication adherence among physically disabled type 2 diabetes mellitus patients. METHODS: Interview sessions were conducted at diabetes clinic-Penang general hospital. The invited participants represented three major ethnic groups of Malaysia (Malay, Chinese and Indians). An open-ended approach was used to elicit answers from participants. Interview questions were related to participant's perception towards self-monitoring blood glucose practices, Awareness towards diet management, behaviour to diabetes medication and cues of action...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28736580/supportive-and-non-supportive-interactions-in-families-with-a-type-2-diabetes-patient-an-integrative-review
#5
REVIEW
Birgitte B Bennich, Michael E Røder, Dorthe Overgaard, Ingrid Egerod, Lene Munch, Filip K Knop, Tina Vilsbøll, Hanne Konradsen
BACKGROUND: Type 2 diabetes and its management affect the patient and the close family potentially causing either psychological distress or increased sense of responsibility and collaboration in these families. Interactions between patient and family play an important role in maintaining lifestyle changes and diabetes self-management. The purpose of this integrative review was to summarise and assess published studies on the intra-family perspective of supportive and non-supportive interactions in families with a type 2 diabetes patient...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28736579/changes-of-myocardial-lipidomics-profiling-in-a-rat-model-of-diabetic-cardiomyopathy-using-uplc-q-tof-ms-analysis
#6
Shifen Dong, Rong Zhang, Yaoyue Liang, Jiachen Shi, Jiajia Li, Fei Shang, Xuezhou Mao, Jianning Sun
BACKGROUND: Diabetic cardiomyopathy (DCM) is a serious cardiac dysfunction induced by changes in the structure and contractility of the myocardium that are initiated in part by alterations in energy substrates. The underlying mechanisms of DCM are still under controversial. The observation of lipids, especially lipidomics profiling, can provide an insight into the know the biomarkers of DCM. The aim of our research was to detect changes of myocardial lipidomics profiling in a rat model of diabetic cardiomyopathy...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28729885/cd36-overexpression-a-possible-etiopathogenic-mechanism-of-atherosclerosis-in-patients-with-prediabetes-and-diabetes
#7
M D Lopez-Carmona, M C Plaza-Seron, A Vargas-Candela, F J Tinahones, R Gomez-Huelgas, M R Bernal-Lopez
RATIONALE: CD36 is a scavenger receptor located on monocytes which is involved in foam cell transformation. AIM: To evaluate CD36 expression under different glycemic states in both healthy subjects and in atherosclerotic patients. SUBJECTS AND METHODS: In order to evaluate the possible effects of hyperglycemia on CD36 expression in healthy subjects, an in vitro experiment was carried out using monocyte in three different conditions: extreme hyperglycemia (HG), euglycemia (EG) and in the absence of glucose...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28725273/a-randomized-controlled-trial-comparing-the-effects-of-dapagliflozin-and-dpp-4-inhibitors-on-glucose-variability-and-metabolic-parameters-in-patients-with-type-2-diabetes-mellitus-on-insulin
#8
Hiroshi Nomoto, Hideaki Miyoshi, Hajime Sugawara, Kota Ono, Shingo Yanagiya, Mayuko Oita, Akinobu Nakamura, Tatsuya Atsumi
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors and sodium-glucose co-transporter 2 (SGLT2) inhibitors improve hyperglycemia, and the usefulness of co-administration of DPP-4 inhibitors and insulin therapy has been well established. However, it has been still uncertain whether combination therapy of SGLT2 inhibitors and insulin is superior to that of DPP-4 inhibitors and the latter. Therefore, we investigated the superiority of dapagliflozin on glucose fluctuation compared with DPP-4 inhibitors in patients with type 2 diabetes mellitus (T2DM) on insulin using a continuous glucose monitoring (CGM) system...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28725272/brazilian-guidelines-on-prevention-of-cardiovascular-disease-in-patients-with-diabetes-a-position-statement-from-the-brazilian-diabetes-society-sbd-the-brazilian-cardiology-society-sbc-and-the-brazilian-endocrinology-and-metabolism-society-sbem
#9
REVIEW
Marcello Casaccia Bertoluci, Rodrigo Oliveira Moreira, André Faludi, Maria Cristina Izar, Beatriz D Schaan, Cynthia Melissa Valerio, Marcelo Chiara Bertolami, Ana Paula Chacra, Marcus Vinicius Bolivar Malachias, Sérgio Vencio, José Francisco Kerr Saraiva, Roberto Betti, Luiz Turatti, Francisco Antonio Helfenstein Fonseca, Henrique Tria Bianco, Marta Sulzbach, Adriana Bertolami, João Eduardo Nunes Salles, Alexandre Hohl, Fábio Trujilho, Eduardo Gomes Lima, Marcio Hiroshi Miname, Maria Teresa Zanella, Rodrigo Lamounier, João Roberto Sá, Celso Amodeo, Antonio Carlos Pires, Raul D Santos
BACKGROUND: Since the first position statement on diabetes and cardiovascular prevention published in 2014 by the Brazilian Diabetes Society, the current view on primary and secondary prevention in diabetes has evolved as a result of new approaches on cardiovascular risk stratification, new cholesterol lowering drugs, and new anti-hyperglycemic drugs. Importantly, a pattern of risk heterogeneity has emerged, showing that not all diabetic patients are at high or very high risk. In fact, most younger patients who have no overt cardiovascular risk factors may be more adequately classified as being at intermediate or even low cardiovascular risk...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28702091/educ-dom-comparative-study-of-the-telemonitoring-of-patients-with-type-2-diabetes-versus-standard-monitoring-study-protocol-for-a-randomized-controlled-study
#10
Marie-Christine Turnin, Solène Schirr-Bonnans, Jacques Martini, Jean-Christophe Buisson, Soumia Taoui, Marie-Christine Chauchard, Nadège Costa, Benoît Lepage, Laurent Molinier, Hélène Hanaire
BACKGROUND: The global prevalence of type 2 diabetes is considerable. To avoid or delay its chronic complications, patients with type 2 diabetes should improve blood glucose management by adapting their life style. This involves changing the way in which diabetes is controlled. We believe that, thanks to technological innovations in connected health-monitoring devices, the telemonitoring of type 2 diabetes patients using therapeutic educational tools is likely to help them adapt their treatment and lifestyle habits, and therefore improve blood glucose management...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28702090/translation-and-validation-of-diabetes-self-management-profile-dsmp-into-brazilian-portuguese-language-first-instrument-to-assess-type-1-diabetes-self-management-in-a-pediatric-population
#11
Caroline Gouveia Buff Passone, Lygia Spassapan Oliveira Esteves, Roberta Dias Savoldelli, Michael A Harris, Durval Damiani, Thais Della Manna
OBJECTIVE: To translate and validate the instrument Diabetes Self-Management Profile (DSMP)-Conventional and Flexible Regimens into Brazilian Portuguese language in order to evaluate the quality of diabetes self-management in children and adolescents with type 1 diabetes and their caregivers. METHODS: DSMP was submitted to forward and back translation method and validated in a group of type 1 diabetes youths between 6 and 18 years (n = 102), and their families...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28690682/autologous-bone-marrow-derived-mononuclear-cells-transplantation-in-type-2-diabetes-mellitus-effect-on-%C3%AE-cell-function-and-insulin-sensitivity
#12
Shobhit Bhansali, Pinaki Dutta, Mukesh Kumar Yadav, Ashish Jain, Sunder Mudaliar, Meredith Hawkins, Anura V Kurpad, Deepak Pahwa, Ashok Kumar Yadav, Ratti Ram Sharma, Vivekanand Jha, Neelam Marwaha, Shipra Bhansali, Anil Bhansali
BACKGROUND: Insulin resistance and insulin deficiency are the cardinal defects in the pathogenesis of type 2 diabetes mellitus (T2DM). Despite the plethora of anti-diabetic medications, drugs specifically targeting the β-cells are still desired. Stem cell therapy has emerged as a novel therapeutics strategy to target β-cells; however, their mechanism of action has not been well defined. This study aims to examine the efficacy and safety of autologous bone marrow-derived mononuclear cells (ABM-MNCs) transplantation in T2DM, and explores the mechanistic insights into stem cells action through metabolic studies...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28674557/metabolic-profiling-of-type-1-diabetes-mellitus-in-children-and-adolescents-a-case-control-study
#13
Liene Bervoets, Guy Massa, Wanda Guedens, Evelyne Louis, Jean-Paul Noben, Peter Adriaensens
BACKGROUND: Type 1 diabetes mellitus (T1DM) is one of the most common pediatric diseases and its incidence is rising in many countries. Recently, it has been shown that metabolites other than glucose play an important role in insulin deficiency and the development of diabetes. The aim of our study was to look for discriminating variation in the concentrations of small-molecule metabolites in the plasma of T1DM children as compared to non-diabetic matched controls using proton nuclear magnetic resonance ((1)H-NMR)-based metabolomics...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28670347/low-serum-adiponectin-level-is-associated-with-metabolic-syndrome-and-is-an-independent-marker-of-peripheral-arterial-stiffness-in-hypertensive-patients
#14
Ming-Chun Chen, Chung-Jen Lee, Chiu-Fen Yang, Yu-Chih Chen, Ji-Hung Wang, Bang-Gee Hsu
BACKGROUND: Adiponectin has been implicated in metabolic syndrome (MetS) and arterial stiffness (AS). We aim to determine the relationship between serum adiponectin concentration as well as peripheral AS in hypertensive patients. METHODS: Fasting blood samples were obtained from 101 hypertensive patients. Brachial-ankle pulse wave velocity (baPWV) was measured with an automatic pulse wave analyzer. Serum adiponectin concentrations were determined by using an enzyme immunoassay kit...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28649285/introduction-of-the-diagene-study-clinical-characteristics-pathophysiology-and-determinants-of-vascular-complications-of-type-2-diabetes
#15
Thijs T W van Herpt, Roosmarijn F H Lemmers, Mandy van Hoek, Janneke G Langendonk, Ronald J Erdtsieck, Bert Bravenboer, Annelies Lucas, Monique T Mulder, Harm R Haak, Aloysius G Lieverse, Eric J G Sijbrands
BACKGROUND: Type 2 diabetes is a major healthcare problem. Glucose-, lipid-, and blood pressure-lowering strategies decrease the risk of micro- and macrovascular complications. However, a substantial residual risk remains. To unravel the etiology of type 2 diabetes and its complications, large-scale, well-phenotyped studies with prospective follow-up are needed. This is the goal of the DiaGene study. In this manuscript, we describe the design and baseline characteristics of the study...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28638444/understanding-the-barriers-and-improving-care-in-type-2-diabetes-brazilian-perspective-in-time-to-do-more-in-diabetes
#16
Sérgio Vencio, Päivi M Paldánius, Matthias Blüher, Daniel Giannella-Neto, Rafael Caiado-Vencio, W David Strain
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a complex disease, particularly in a continental country like Brazil. We attempted to understand and evaluate the perceptions and routines of Brazilians with T2DM and physicians, compared with other countries. METHODS: We compared the results from a 20-min online survey in Brazil with simultaneously collated data from India, Japan, Spain, UK and USA. RESULTS: In total, 652 adults with T2DM and 337 treating physicians were enrolled, of whom 100 patients and 55 physicians were from Brazil...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28630652/verification-of-b-lymphocyte-activating-factor-s-involvement-in-the-exacerbation-of-insulin-resistance-as-well-as-an-autoimmune-response-in-patients-with-nonalcoholic-steatohepatitis-and-patients-with-hcv-related-chronic-liver-disease
#17
Takashi Himoto, Koji Fujita, Takako Nomura, Joji Tani, Asahiro Morishita, Hirohito Yoneyama, Reiji Haba, Tsutomu Masaki
BACKGROUND: Ten to forty percent of nonalcoholic steatohepatitis (NASH) and HCV-related chronic liver disease (CLD-C) patients have antinuclear antibodies (ANAs). However, the relationship between autoimmune response and insulin resistance remains uncertain among those patients. The primary purpose of this study was to investigate whether or not ANA status was associated with the development of insulin resistance and obesity in NASH and CLD-C patients. METHODS: Degrees of hepatic fibrosis and steatosis were evaluated by the classification proposed by Brunt et al...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28580018/the-burden-of-obesity-in-the-current-world-and-the-new-treatments-available-focus-on-liraglutide-3-0%C3%A2-mg
#18
REVIEW
Marcio C Mancini, Maria Edna de Melo
The prevalence of obesity increases worldwide. Treating obesity and its associated health problems has a significant economic impact on health care systems. The unsatisfactory long-term outcomes observed in the obesity treatment are due to its complex pathophysiology and the inherent difficulties associated with maintenance of lifestyle modifications. Determined by genetic and environmental factors, obesity has been officially recognized as a chronic disease, an action that allowed the recognition of anti-obesity drugs as legitimate therapeutic options to address the growing obesity endemic...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28572856/unacylated-ghrelin-modulates-circulating-angiogenic-cell-number-in-insulin-resistant-states
#19
Behiye Özcan, Pieter J M Leenen, Patric J D Delhanty, Lucy Y Baldéon-Rojas, Sebastian J Neggers, Aart Jan van der Lely
BACKGROUND: Type 2 diabetes (T2D) is associated with reduced numbers and impaired function of circulating angiogenic cells (CAC) which contributes to the progression of atherosclerosis and microvascular disease. Previous studies suggest that short-term infusion of unacylated ghrelin (UAG) normalizes CAC number in patients with T2D. To determine dose-dependent effects of short-term infusion of UAG in T2D patients using a cross-over model, and of long-term infusion of UAG in obese mice, on differentiation of monocyte progenitors into CAC...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28572855/skin-autofluorescence-a-non-invasive-biomarker-for-advanced-glycation-end-products-is-associated-with-the-metabolic-syndrome-and-its-individual-components
#20
Robert P van Waateringe, Sandra N Slagter, Andre P van Beek, Melanie M van der Klauw, Jana V van Vliet-Ostaptchouk, Reindert Graaff, Andrew D Paterson, Helen L Lutgers, Bruce H R Wolffenbuttel
BACKGROUND: The metabolic syndrome (MetS) comprises several cardiometabolic risk factors associated with increased risk for both type 2 diabetes and cardiovascular disease. Skin autofluorescence (SAF), a non-invasive biomarker of advanced glycation end products accumulation, is associated with cardiovascular complications in subjects with diabetes. The aim of the present study was to examine the association between SAF and the presence of MetS as well as its individual components in a general population...
2017: Diabetology & Metabolic Syndrome
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