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Diabetology & Metabolic Syndrome

Miho Akaza, Itaru Akaza, Tadashi Kanouchi, Tetsuo Sasano, Yuki Sumi, Takanori Yokota
Background: It remains unclear whether glycemic variability is related to diabetes microvascular disease, especially diabetes peripheral neuropathy (DPN). We investigated the association between glycemic variability and DPN with type 1 or 2 diabetes. Methods: Forty patients (23 males and 17 females; aged 34-79 years) underwent continuous glucose monitoring (CGM) and a nerve conduction study (NCS). Glycemic variability was estimated by mean amplitude of glycemic excursions (MAGE) in CGM...
2018: Diabetology & Metabolic Syndrome
Wen Zheng, Yuli Liu, Haibao Shang, Yan Zhang, Dongwei Ma, Ning Hou, Jue Wang, Xueting Sun, Ying Peng, Lin Pan, Zhilong Wang, Xinran Tang, Rui-Ping Xiao, Xiuqin Zhang
Background: Non-alcoholic fatty liver disease (NAFLD) is a global epidemic afflicting 20-30% in the general population. The animal model of NAFLD available at the present are less clinically relevant. In this study. We aimed to establish a NAFLD model of rhesus monkeys and develop an ultrasonographic steatosis score (USS) system to grade hepatic steatosis in this model. Methods: We performed hepatic ultrasonography and blood biochemical tests on 86 rhesus monkeys with and without metabolic syndrome (MetS), among which 45 animals were further assessed by histopathological analysis...
2018: Diabetology & Metabolic Syndrome
Arash Salahshouri, Fereshteh Zamani Alavijeh, Behzad Mahaki, Firoozeh Mostafavi
Background: Managing type 2 diabetes (T2D) is assumed to be heavily dependent on patients' active participation in their own self-care behaviors including prescribed diets. Objectives: The purpose of the present study was to investigate the effectiveness of educational intervention based on psychological factors on nutritional behaviors as well as levels of fasting blood sugar (FBS) and glycated hemoglobin (HbA1c) in patients with T2D referring to diabetes clinics and healthcare centers in the city of Izeh, Iran...
2018: Diabetology & Metabolic Syndrome
Ji-Ryang Kim, Ha-Na Kim, Sang-Wook Song
Background: Metabolic syndrome (MetS), a pro-inflammatory state, has become increasingly common worldwide and is a major risk factor for type 2 diabetes mellitus and cardiovascular disease. Recently, studies on the relationships among inflammation, mental health, quality of life, and other diseases have been conducted. Methods: We investigated the relationship between serum high-sensitivity C-reactive protein (hs-CRP) levels, as an indicator of inflammation, and the quality of life and psychiatric symptoms of Korean adults with MetS...
2018: Diabetology & Metabolic Syndrome
Luciana Pavan Antoniolli, Bárbara Limberger Nedel, Tassia Cividanes Pazinato, Leonardo de Andrade Mesquita, Fernando Gerchman
Background: This study aimed to determine the ability of commonly used insulin resistance indices to identify the metabolic syndrome. Methods: 183 people referred for outpatient care at the Metabolism Unit of Hospital de Clínicas de Porto Alegre were evaluated with anthropometric, blood pressure, lipid profile, and adiponectin measurements. Glucose tolerance status was determined by 2-h 75-g oral glucose tolerance test and glycosylated hemoglobin. Definition of metabolic syndrome was based on the Joint Interim Statement of different medical associations...
2018: Diabetology & Metabolic Syndrome
Kanta Fujimoto, Toshio Iwakura, Megumi Aburaya, Naoki Matsuoka
Background: Previous studies comparing insulin degludec/insulin aspart (IDegAsp) with premixed insulin twice daily among insulin users with type 2 diabetes have not thoroughly investigated differences in the glucose variability and psychological evaluations related to insulin regimen changes. We investigated changes in the daily and day-to-day glucose variability and quality of life (QOL) related to insulin use in patients with type 2 diabetes during a switch from premixed insulin preparations comprising either human insulin (BHI30) or insulin aspart (BIAsp30) to IDegAsp twice daily...
2018: Diabetology & Metabolic Syndrome
Keiko Koide, Koichiro Azuma, Jun Nojima, Kenichiro Kodama, Yoshihito Atsumi
Background: Flash glucose monitoring (FGM) is a factory-calibrated, blood glucose measuring sensor system for patients with diabetes. We aimed to investigate the correlation between the sensor glucose (SG) value obtained using an FGM device and the traditional self-monitoring of blood glucose (SMBG) value. Methods: In 30 patients with diabetes under insulin treatment, SG and SMBG values were measured for 2 weeks, and the correlation between the values was analyzed...
2018: Diabetology & Metabolic Syndrome
Mohammad Ishraq Zafar, Kerry Mills, Xiaofeng Ye, Brette Blakely, Jie Min, Wen Kong, Nan Zhang, Luoning Gou, Anita Regmi, Sheng Qing Hu, Juan Zheng, Lu-Lu Chen
Background: Several studies have linked vascular endothelial growth factors (VEGFs) with metabolic syndrome or its components. However, there has been no systematic appraisal of the findings of these studies to date. The current systematic review and meta-analysis was conducted to explore this association. Methods: PubMed, EMBASE, the Cochrane library, and clinical trials registries were used to retrieve peer-reviewed clinical studies that had evaluated the association of VEGFs with metabolic syndrome or its components without applying language and date restrictions...
2018: Diabetology & Metabolic Syndrome
Xunwen Lei, Guifeng Zeng, Yuemei Zhang, Qiang Li, Jinzhi Zhang, Zhenggang Bai, Kehu Yang
Background: Previous studies have demonstrated that elevated homocysteine (Hcy) level represents an independent risk factor for macrovascular disease. However, the relationship between hyperhomocysteinemia and the progression of diabetic retinopathy in patients remains controversial. Hence, the purpose of this systematic review and meta-analysis was to explore any potential association between Hcy and the risk of diabetic retinopathy. Methods: PubMed, Embase, and the Cochrane Library databases were searched to screen studies that fulfilled the inclusion criteria from date of database inception to November 2017...
2018: Diabetology & Metabolic Syndrome
Olga Lamacchia, Francesca Viazzi, Paola Fioretto, Antonio Mirijello, Carlo Giorda, Antonio Ceriello, Giuseppina Russo, Pietro Guida, Roberto Pontremoli, Salvatore De Cosmo
Background: We described, in a large sample of patients with type 1 diabetes mellitus (T1DM) and GFR ≤ 60 mL/min/1.73 m2 (with or without albuminuria), the differences in the clinical features associated with the two different chronic kidney disease phenotypes and we investigated, in a subset of patients, the modulating role of albuminuria on kidney disease progression. Methods: Clinical data of 1395 patients with T1DM were extracted from electronic medical records...
2018: Diabetology & Metabolic Syndrome
Ayodeji Awoyemi, Marius Trøseid, Harald Arnesen, Svein Solheim, Ingebjørg Seljeflot
Background: Metabolic syndrome (MetS) is a cluster of conditions that conjoined represents a 1.5-2.5 fold increased risk of developing cardiovascular disease (CVD). Recent studies have reported that gut dysbiosis and leakage of bacterial components, may contribute to the metabolic disturbances and systemic inflammation observed in subjects with MetS. Chronic exposure to lipopolysaccharide (LPS) has been shown to induce features of MetS in experimental studies. LPS interacts with the innate immune system, facilitated through LPS-binding protein (LBP) and the co-receptor CD14, both regarded as markers of gut leakage...
2018: Diabetology & Metabolic Syndrome
Yu Meng, Alfonso Eirin, Xiang-Yang Zhu, Daniel R O'Brien, Amir Lerman, Andre J van Wijnen, Lilach O Lerman
Background: Mesenchymal stem cells (MSCs) perform paracrine functions by releasing extracellular vesicles (EVs) containing microRNA, mRNA, and proteins. We investigated the mRNA content of EVs in metabolic syndrome (MetS) and tested hypothesis that comorbidities interfere with the paracrine functionality of MSCs. Methods: Mesenchymal stem cells were collected from swine abdominal adipose tissue after 16 weeks of a low- (Lean) or high-calorie (MetS) diet (n = 5 each)...
2018: Diabetology & Metabolic Syndrome
Mayada Issa, Fahad Alqahtani, Chalak Berzingi, Mohammad Al-Hajji, Tatiana Busu, Mohamad Alkhouli
Background: Acute hyperglycemia is associated with worse outcomes in diabetic patients admitted with ST-elevation myocardial infarction (STEMI). However, the impact of full-scale decompensated diabetes on STEMI outcomes has not been investigated. Methods: We utilized the national inpatient sample (2003-2014) to identify adult diabetic patients admitted with STEMI. We defined decompensated diabetes as the presence of diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar state (HHS)...
2018: Diabetology & Metabolic Syndrome
Sung-Sheng Tsai, Yun-Yi Chu, Szu-Tah Chen, Pao-Hsien Chu
Background: The reported outcomes of the metabolic syndrome (MetS), containing atherosclerotic cardiovascular disease and diabetes, vary according to the definitions used. This study was designed to compare the performance of the Adult Treatment Panel III/American Heart Association/National Heart, Lung, and Blood Institute (ATP III/AHA/NHLBI) and International Diabetes Federation (IDF) criteria for the risks of atherosclerosis and diabetes. Methods: We sifted subjects from a self-paid Health examination program from 1999 to 2015 in this cross-sectional population-based study...
2018: Diabetology & Metabolic Syndrome
Ryuichi Kawamoto, Daisuke Ninomiya, Asuka Kikuchi, Taichi Akase, Teru Kumagi
Background: Elevated serum uric acid (SUA) levels are associated with glucose control. However, whether baseline and changes in SUA predict long-term follow-up glucose control [e.g., glycated hemoglobin (HbA1c)] remains unclear. Methods: The subjects comprised 393 women aged 71 ± 8 years and 279 men aged 71 ± 10 years from a rural village. We have identified participants who underwent a similar examination 11 years prior, and subjects were divided into four groups based on the tertiles of baseline and changes in SUA, and examined the relationship between baseline and changes in SUA, and glucose control evaluated by follow-up HbA1c after 11-years...
2018: Diabetology & Metabolic Syndrome
Adriana Cezaretto, Claudia Kimie Suemoto, Isabela Bensenor, Paulo A Lotufo, Bianca de Almeida-Pititto, Sandra R G Ferreira
Background: Adiponectin is an insulin-sensitizer adipocytokine endowed with neuroprotective actions. Whether adiponectin regulates neuronal functioning toward delaying cognitive decline independently of the glucose metabolism disturbance has been poorly explored. This study evaluated if the performance in cognitive tests was associated with adiponectin levels prior the development of type 2 diabetes in middle-aged individuals. Methods: A sample of 938 non-diabetic participants of ELSA had their cognitive function assessed by the CERAD delayed word recall test, the verbal fluency test and the trail making test...
2018: Diabetology & Metabolic Syndrome
Juhyun Song, So Ra Yoon, Oh Yoen Kim
Background: Low adiponectin levels are associated with increased insulin resistance (IR) and arterial stiffness in hypertensive patients, but higher adiponectin levels are also found in heart failure patients. This discrepancy has not been fully resolved, but it may be related to the adiponectin gene ( ADIPOQ ) which regulates adiponectin production. We aimed to investigate whether the relationship between adiponectin and arterial stiffness is associated with ADIPOQ rs1501299 G/T polymorphism in nondiabetic Korean men...
2018: Diabetology & Metabolic Syndrome
Valeria Calcaterra, Jonathan P Winickoff, Catherine Klersy, Luca Maria Schiano, Rossella Bazzano, Chiara Montalbano, Valeria Musella, Corrado Regalbuto, Daniela Larizza, Hellas Cena
Background: To evaluate the relationship between smoking and metabolic parameters in patients affected by type 1 diabetes (T1D). Patients and methods: We enrolled 104 children and young adults (50 females and 54 males) with T1D (aged 16.4 ± 8.6 years). The subjects were divided into three groups according to their smoking habits: no smoking (NS), passive smoking (PS), active smoking (AS). The physical examination of the participants included nutritional status assessment by anthropometry and pubertal stage according to Marshall and Tanner as well as blood pressure measurement...
2018: Diabetology & Metabolic Syndrome
Roya Kelishadi, Ramin Heshmat, Marjan Mansourian, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Zeinab Ahadi, Tahereh Aminaee, Azam Goodarzi, Morteza Mansourian, Mostafa Qorbani, Nafiseh Mozafarian
Objective: This study aims to determine the association of dietary patterns with metabolic syndrome (MetS) and its components in children and adolescents. Methods: This nationwide study was conducted in 2015 among 4200 students aged 7-18 years, who lived in 30 provinces in Iran. The analysis was conducted based on the propensity score using a matched case-control study design. Three dietary patterns were obtained conducting a principal component analysis with a varimax rotation on 16 dietary groups...
2018: Diabetology & Metabolic Syndrome
Qiuyi Ke, Chaogang Chen, Fengyi He, Yongxin Ye, Xinxiu Bai, Li Cai, Min Xia
Background: Epidemiological studies have demonstrated that high total protein intake was related to type 2 diabetes mellitus (T2DM) risks. However, few studies considered the impact of dietary pattern. Objective: We examined the associations between protein intake and T2DM in different dietary patterns. Methods: We used the demographic and dietary information of adults aged 18-75 years from the China Health and Nutrition Survey (2009), consisting of 4113 women and 4580 men...
2018: Diabetology & Metabolic Syndrome
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