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Diabetology & Metabolic Syndrome

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https://www.readbyqxmd.com/read/29456629/acute-vitamin-c-improves-cardiac-function-not-exercise-capacity-in-adults-with-type-2-diabetes
#1
Rebecca L Scalzo, Timothy A Bauer, Kylie Harrall, Kerrie Moreau, Cemal Ozemek, Leah Herlache, Shawna McMillin, Amy G Huebschmann, Jennifer Dorosz, Jane E B Reusch, Judith G Regensteiner
Background: People with type 2 diabetes (T2D) have impaired exercise capacity, even in the absence of complications, which is predictive of their increased cardiovascular mortality. Cardiovascular dysfunction is one potential cause of this exercise defect. Acute infusion of vitamin C has been separately shown to improve diastolic and endothelial function in prior studies. We hypothesized that acute vitamin C infusion would improve exercise capacity and that these improvements would be associated with improved cardiovascular function...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29449893/endoplasmic-reticulum-stress-activation-in-adipose-tissue-induces-metabolic-syndrome-in-individuals-with-familial-partial-lipodystrophy-of-the-dunnigan-type
#2
Maria C Foss-Freitas, Rafael C Ferraz, Luciana Z Monteiro, Patricia M Gomes, Ricardo Iwakura, Luiz Carlos C de Freitas, Milton C Foss
Background: Familial partial lipodystrophy of the Dunnigan type is one of the most common inherited lipodystrophies variables. These individuals have important metabolic disorders that cause predisposition to various diseases. In this study we aimed to demonstrate the relation between the metabolic abnormalities, inflammatory profile and the expression of genes involved in the activation of the endoplasmic reticulum stress (ERS) in subjects with FPLD. Methods: We evaluated 14 female FPLD patients and compared with 13 female healthy individuals...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29434676/plasma-levels-of-lipopolysaccharide-correlate-with-insulin-resistance-in-hiv-patients
#3
Marcelo Nardi Pedro, Daniela Oliveira Magro, Elizabete Urbano Pinaço Pinto da Silva, Dioze Guadagnini, Andrey Santos, Rogerio de Jesus Pedro, Mario José Abdalla Saad
Background: In HIV patients using HAART insulin resistance is a central pathophysiological condition that can contribute to the development of diabetes and cardiovascular complications. To examine the role of adipocyte hormones and LPS in insulin resistance in HIV patients, we investigated the role of adiponectin, leptin, visfatin and LPS levels in the insulin resistance of HIV-infected patients treated with HAART. Methods: This study included 67 HIV positive individuals on HAART and ten healthy controls...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29410708/dietary-fat-stimulates-development-of-nafld-more-potently-than-dietary-fructose-in-sprague-dawley-rats
#4
Victoria Svop Jensen, Henning Hvid, Jesper Damgaard, Helle Nygaard, Camilla Ingvorsen, Erik Max Wulff, Jens Lykkesfeldt, Christian Fledelius
Background: In humans and animal models, excessive intake of dietary fat, fructose and cholesterol has been linked to the development of non-alcoholic fatty liver disease (NAFLD). However, the individual roles of the dietary components remain unclear. To investigate this further, we compared the effects of a high-fat diet, a high-fructose diet and a combination diet with added cholesterol on the development of NAFLD in rats. Methods: Forty male Sprague-Dawley rats were randomized into four groups receiving either a control-diet (Control: 10% fat); a high-fat diet (HFD: 60% fat, 20% carbohydrate), a high-fructose diet [HFr: 10% fat, 70% carbohydrate (mainly fructose)] or a high-fat/high-fructose/high-cholesterol-diet (NASH: 40% fat, 40% carbohydrate (mainly fructose), 2% cholesterol) for 16 weeks...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29339974/multidisciplinary-treatment-of-patients-with-diabetes-and-hypertension-experience-of-a-brazilian-center
#5
Thiago Veiga Jardim, Sayuri Inuzuka, Luan Galvão, Leandra Anália Freitas Negretto, Rogério Orlow de Oliveira, Wanessa Faria Sá, Haroldo Silva de Souza, Andrea Crisitina Sousa, Patricia Silva Carneiro, Weimar Kunz Sebba Barroso, Ana Luiza Lima Sousa, Paulo César Veiga Jardim
Background: Although multidisciplinary treatment is recommended for type 2 diabetes mellitus and hypertension (HTN), there is a lack of scientific literature supporting the hypothesis of extending this treatment strategy to patients with both diabetes and HTN. Aiming to report results of long-term multidisciplinary treatment for these patients and identify strategies to improve their management, we conducted this study. Methods: Data of patients with diabetes and HTN with regular follow-up visits in a multidisciplinary HTN treatment center from Brazil's Midwest were retrospectively assessed...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29308091/postpartum-follow-up-of-gestational-diabetes-in-a-tertiary-care-center
#6
C A Cabizuca, P S Rocha, J V Marques, T F L R Costa, A S N Santos, A L Schröder, C A G Mello, H D Sousa, E S G Silva, F O Braga, R C Abi-Abib, M B Gomes
Background: Gestational diabetes is a risk factor for future development of type 2 diabetes. The primary aim of this study was to estimate the prevalence of postpartum glucose tolerance status evaluation in pregnancies complicated by gestational diabetes 6-12 weeks after delivery. The secondary one was to identify the factors that are implicated with postpartum glucose retesting. Methods: This was a retrospective study performed with a cohort of women with gestational diabetes, with prenatal care and delivery at a tertiary care center, from January 2013 to April 2017...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29308090/effects-of-incretin-treatment-on-cardiovascular-outcomes-in-diabetic-stemi-patients-with-culprit-obstructive-and-multivessel-non-obstructive-coronary-stenosis
#7
Raffaele Marfella, Celestino Sardu, Maria Luisa Balestrieri, Mario Siniscalchi, Fabio Minicucci, Giuseppe Signoriello, Paolo Calabrò, Ciro Mauro, Gorizio Pieretti, Antonino Coppola, Gianfranco Nicoletti, Maria Rosaria Rizzo, Giuseppe Paolisso, Michelangela Barbieri
Background: No proper data on prognosis and management of type-2 diabetic ST elevation myocardial infarction (STEMI) patients with culprit obstructive lesion and multivessel non obstructive coronary stenosis (Mv-NOCS) exist. We evaluated the 12-months prognosis of Mv-NOCS-diabetics with first STEMI vs.to non-diabetics, and then Mv-NOCS-diabetics previously treated with incretin based therapy vs. a matched cohort of STEMI-Mv-NOCS never treated with such therapy. Methods: 1088 Patients with first STEMI and Mv-NOCS were scheduled for the study...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29299069/bile-acids-at-the-cross-roads-of-gut-microbiome-host-cardiometabolic-interactions
#8
REVIEW
Paul M Ryan, Catherine Stanton, Noel M Caplice
While basic and clinical research over the last several decades has recognized a number of modifiable risk factors associated with cardiometabolic disease progression, additional and alternative biological perspectives may offer novel targets for prevention and treatment of this disease set. There is mounting preclinical and emerging clinical evidence indicating that the mass of metabolically diverse microorganisms which inhabit the human gastrointestinal tract may be implicated in initiation and modulation of cardiovascular and metabolic disease outcomes...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29299068/muscle-irisin-response-to-aerobic-vs-hiit-in-overweight-female-adolescents
#9
Carolina Archundia-Herrera, Maciste Macias-Cervantes, Bernardo Ruiz-Muñoz, Katya Vargas-Ortiz, Carlos Kornhauser, Victoriano Perez-Vazquez
Background: Exercise stimulates the production of fibronectin type III domain-containing protein 5 (FNDC5), which is cleaved to release a protein called irisin. This protein induces browning of white adipose tissue resulting in increased thermogenesis. Different studies have measured circulating irisin at baseline and in response to exercise among a wide variety of individuals; yet, regarding the effect of different exercise intensities in obese adolescent girls, limited insight is available...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29296123/hypertensive-diabetic-patients-incidence-of-cardiovascular-and-renal-outcomes-in-a-historical-cohort-over-11%C3%A2-years
#10
Andréa Cristina Sousa, Thiago Veiga Jardim, Thiago Olivera Costa, Fabrício Galdino Magalhães, Marcos Paulo Marinho Montelo, Weimar K Barroso Souza, Paulo César Brandão Veiga Jardim, Ana Luiza Lima Sousa
Background: Diabetics have increased risks for cardiovascular disease (CVD) and mortality, reducing their life expectancy by up to 15 years. Type 2 diabetes mellitus specifically increases the risk for cardiovascular mortality nearly fivefold. When hypertension is combined with diabetes, the risk of CVD is even greater. Objective: Identify non-fatal cardiovascular outcomes and renal function impairment in a cohort of hypertensive patients in regular treatment in a reference treatment center, over 11 years of follow-up...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29259658/type-1-diabetes-does-not-impair-the-physical-capacity-of-non-sedentary-adolescents
#11
Milena S Nascimento, Carolina F Espindola, Cristiane do Prado, Melina Blanco Amarins, Ana Lucia Potenza, Luciana Pacheco, Erica Santos, Teresa Cristina A Vieira
Background: Type 1 diabetes patients have a higher risk of developing hypoglycemia or hyperglycemia during physical activity, which may compromise their safety during exercise but results regarding the exercise capacity of patients with type 1 DM when compared to control subjects have been contradictory. Aim: To evaluate if type 1 diabetes affects the capacity of adolescents to exercise. Methods: The study enrolled 37 adolescents in stage 2-4 of the Tanner scale, aged from 10 to 14 years, 21 with type 1 diabetes and 16 without any chronic diseases...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29255491/favourable-metabolic-profile-sustains-mitophagy-and-prevents-metabolic-abnormalities-in-metabolically-healthy-obese-individuals
#12
Shipra Bhansali, Anil Bhansali, Veena Dhawan
Background: Obesity-mediated oxidative stress results in mitochondrial dysfunction, which has been implicated in the pathogenesis of metabolic syndrome and T2DM. Recently, mitophagy, a cell-reparative process has emerged as a key facet in maintaining the mitochondrial health, which may contribute to contain the metabolic abnormalities in obese individuals. However, the status of mitophagy in metabolically healthy obese (MHO) and metabolically abnormal diabetic obese (MADO) subjects remains to be elucidated...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29225702/the-influence-of-dopamine-beta-hydroxylase-and-catechol-o-methyltransferase-gene-polymorphism-on-the-efficacy-of-insulin-detemir-therapy-in-patients-with-type-2-diabetes-mellitus
#13
Tomislav Bozek, Antonela Blazekovic, Matea Nikolac Perkovic, Kristina Gotovac Jercic, Aleksandra Sustar, Lea Smircic-Duvnjak, Tiago F Outeiro, Nela Pivac, Fran Borovecki
Background: Type II diabetes is an important health problem with a complex connection to obesity, leading to a broad range of cardiovascular complications. Insulin therapy often results in weight gain and does not always ensure adequate glycemic control. However, previous studies reported that insulin detemir is an efficient long-acting insulin with a weight sparing effect. The aim of this study was to determine the association of catechol O-methyltransferase (COMT) Val108/158Met and dopamine-beta-hydroxylase (DBH) 1021C/T polymorphisms with the effectiveness of insulin detemir in achieving glucose control and body weight control...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29213337/effectiveness-of-long-term-treatment-with-sglt2-inhibitors-real-world-evidence-from-a-specialized-diabetes-center
#14
Yotsapon Thewjitcharoen, Nalin Yenseung, Areeya Malidaeng, Soontaree Nakasatien, Phawinpon Chotwanvirat, Sirinate Krittiyawong, Ekgaluck Wanothayaroj, Thep Himathongkam
Background: Diabetes is a progressive disease needing multiple drugs for achieving and maintaining good glycemic control. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) is a novel class of anti-diabetic agent which offers several beneficial effects. However, the long-term effectiveness in clinical practice and safety data of SGLT2 inhibitors is limited, especially in Asian patients. To better understand the effectiveness of SGLT2i in clinical practice, we conducted a retrospective evaluation of patients with diabetes on SGLT2i...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29213336/adiponectin-resistin-interplay-in-serum-and-in-adipose-tissue-of-obese-and-normal-weight-individuals
#15
Marta Izabela Jonas, Alina Kurylowicz, Zbigniew Bartoszewicz, Wojciech Lisik, Maurycy Jonas, Justyna Domienik-Karlowicz, Monika Puzianowska-Kuznicka
Background: The interplay between adiponectin and resistin, the two adipokines of opposite effects, may determine the metabolic profile of obese individuals and development of obesity-related complications. The current study was conducted to assess how adiponectin/resistin interplay in sera and adipose tissues may influence the metabolic profile of obese and normal-weight subjects. Methods: Concentrations of adiponectin and resistin were measured on protein level by immunoassay in visceral and subcutaneous adipose tissues from 50 obese (body mass index > 40 kg/m2) and 28 normal-weight (body mass index 20-24...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29213335/liraglutide-attenuates-atherosclerosis-via-inhibiting-er-induced-macrophage-derived-microvesicles-production-in-t2dm-rats
#16
Jinjin Li, Xiaojuan Liu, Qianhua Fang, Min Ding, Chunjun Li
Background: We investigated the effects of liraglutide on the formation and progression of atherosclerosis in type 2 diabetes mellitus (T2DM) rats. Methods: Sprague-Dawley rats were divided into control group, diabetes group and liraglutide treated group. The T2DM rats model with atherosclerosis were induced by high fat diet followed small dosage streptozotocin injection. Body weight and blood glucose levels were monitored once a week for 3 months and then the rats were sacrificed...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29201153/poor-glycaemic-control-is-associated-with-reduced-exercise-performance-and-oxygen-economy-during-cardio-pulmonary-exercise-testing-in-people-with-type-1-diabetes
#17
Othmar Moser, Max L Eckstein, Olivia McCarthy, Rachel Deere, Stephen C Bain, Hanne L Haahr, Eric Zijlstra, Richard M Bracken
Background: To explore the impact of glycaemic control (HbA1c) on functional capacity during cardio-pulmonary exercise testing in people with type 1 diabetes. Methods: Sixty-four individuals with type 1 diabetes (age: 34 ± 8 years; 13 females, HbA1c: 7.8 ± 1% (62 ± 13 mmol/mol), duration of diabetes: 17 ± 9 years) performed a cardio-pulmonary cycle ergometer exercise test until volitional exhaustion. Stepwise linear regression was used to explore relationships between HbA1c and cardio-respiratory data with p ≤ 0...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29201152/myocardial-injury-in-diabetic-patients-with-multivessel-coronary-artery-disease-after-revascularization-interventions
#18
Paulo Cury Rezende, Whady Hueb, Rosa Maria Rahmi, Thiago Luis Scudeler, Diogo Freitas Cardoso de Azevedo, Cibele Larrosa Garzillo, Carlos Alexandre Wainrober Segre, Jose Antonio Franchini Ramires, Roberto Kalil Filho
Background: Diabetic patients may be more susceptible to myocardial injury after coronary interventions. Thus, the aim of this study was to assess the release of cardiac biomarkers, CK-MB and troponin, and the findings of new late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) in patients with type 2 diabetes mellitus after elective revascularization procedures for multivessel coronary artery disease (CAD). Methods: Patients with multivessel CAD and preserved systolic ventricular function underwent either elective percutaneous coronary intervention (PCI), off-pump or on-pump bypass surgery (CABG)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29177013/vitamin-d-is-associated-with-metabotropic-but-not-neurotrophic-effects-of-exercise-in-ovariectomized-rats
#19
Parvin Babaei, Samaneh Ghorbani Shirkouhi, Rastegar Hosseini, Bahram Soltani Tehrani
Purpose: Here, we studied the beneficial effects of aerobic exercise on metabolic syndrome components, cognitive performance, brain derived neurotrophic factor (BDNF) and irisin in ovariectomized rats with different serum vitamin D (Vit D) status. Methods: Eighty female wistar rats were divided into 2 groups of sham operated (sham, n = 8), and ovariectomized (OVX, n = 72). Then OVX were divided into 9 groups of receiving combination of exercise protocol with low dose of Vit D (OVX + EXE + LD), high dose of Vit D (OVX + EXE + HD), Vit D deficiency (OVX + EXE - D), and (OVX + EXE + Veh)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29163673/effects-of-pioglitazone-therapy-on-blood-parameters-weight-and-bmi-a-meta-analysis
#20
REVIEW
Elena Filipova, Katya Uzunova, Krassimir Kalinov, Toni Vekov
Background: Type 2 diabetes mellitus (T2DM) is one of the most common diseases worldwide and insulin insufficiency and insulin resistance are two main metabolic issues connected with it. The dyslipidemia associated with insulin resistance and T2DM is characterized by higher triglycerides (TGs), higher very-low-density lipoprotein cholesterol and lower apo A1. Pioglitazone, a member of the thiazolidinedione class, with a proven antihyperglycemic effect, is known to positively influence insulin sensitivity and β-cell function and to have the potential to alter the lipid profile...
2017: Diabetology & Metabolic Syndrome
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