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Diabetology & Metabolic Syndrome

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https://www.readbyqxmd.com/read/27895721/hypoadiponectinemia-and-the-presence-of-metabolic-syndrome-in-patients-with-chronic-kidney-disease-results-from-the-know-ckd-study
#1
Chang-Yun Yoon, Yung Ly Kim, Seung Hyeok Han, Tae-Hyun Yoo, Su-Ah Sung, Woo-Kyung Chung, Dong-Wan Chae, Yong-Soo Kim, Curie Ahn, Kyu Hun Choi
BACKGROUND: In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. Adiponectin is known to have anti-atherogenic and cardio-protective effects. Meanwhile, the relationship between adiponectin and metabolic syndrome in patients with chronic kidney disease has not been clarified. The aim of this study was to elucidate the relationship between adiponectin level and metabolic syndrome in patients with chronic kidney disease...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27895720/increased-carotid-intima-media-thickness-in-brazilian-adolescents-with-type-1-diabetes-mellitus
#2
Maria Fernanda Gontijo Sepulveda Fusaro, Jovita Lane Soares Santos Zanini, Ivani Novato Silva
BACKGROUND: Increased carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is an independent predictor of future cardiovascular events, and has been reported in children with various chronic diseases, including type 1 diabetes mellitus (DM1). OBJECTIVES: Evaluate CIMT and its association with cardiovascular risk factors in Brazilian adolescents with DM1. METHODS: Cross-sectional study of 118 adolescents, 57 with DM1 and no chronic complications related to the disease, and 61 healthy individuals...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27891186/relationship-between-vitamin-d-status-glycemic-control-and-cardiovascular-risk-factors-in-brazilians-with-type-2-diabetes-mellitus
#3
Maria Creusa Rolim, Bárbara Mendes Santos, Gildasio Conceição, Paulo Novis Rocha
OBJECTIVES: Determine the prevalence and identify predictors of hypovitaminosis D in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels with variables indicative of glycemic control and cardiovascular risk. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional study with consecutive patients treated at a University Hospital's Endocrinology outpatient clinic located at 12°58'S latitude, between October 2012 and November 2013. Hypovitaminosis D was defined as 25-hydroxyvitamin D < 30 ng/mL (chemiluminescence)...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27891185/spermatozoal-cell-death-inducing-dna-fragmentation-factor-%C3%AE-like-effector-a-cidea-gene-expression-and-dna-fragmentation-in-infertile-men-with-metabolic-syndrome-and-normal-seminogram
#4
Ayman Z Elsamanoudy, Hussein Abdelaziz Abdalla, Mohammed Hassanien, Mohammad A Gaballah
BACKGROUND: This is the first study to investigate spermatozoal cell death-inducing DNA fragmentation factor-α-like effector A (CIDEA) gene expression and DNA fragmentations in the spermatozoa of men diagnosed with metabolic syndrome (MS) who have normal seminograms with unexplained infertility, and to correlate these parameters with seminal glucose concentration. METHODS: This study included 120 participants: 75 male subjects with MS (38 fertile and 37 infertile), and a control group of 45 fertile males without MS...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27843495/adipose-tissue-dysfunction-increases-fatty-liver-association-with-pre-diabetes-and-newly-diagnosed-type-2-diabetes-mellitus
#5
Esteban Jorge-Galarza, Aida Medina-Urrutia, Rosalinda Posadas-Sánchez, Carlos Posadas-Romero, Guillermo Cardoso-Saldaña, Gilberto Vargas-Alarcón, Nacú Caracas-Portilla, Carmen González-Salazar, Margarita Torres-Tamayo, Juan Gabriel Juárez-Rojas
BACKGROUND: To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D). METHODS: In 1264 subjects, computed tomography was used to evaluate FL and elevated visceral adipose tissue (VAT). Fasting plasma glucose, <5.6, 5.6-6.9 and ≥7 mmol/l, were used to defined normoglycemic (NG), IFG or nT2D, respectively. Elevated free fatty acids, low serum adiponectin levels and adipose tissue insulin resistance (Adipo-IR), were used as markers of adipose tissue dysfunction...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27843494/changes-in-antidiabetic-prescription-patterns-and-indicators-of-diabetic-control-among-200-000-patients-over-13%C3%A2-years-at-a-single-institution-in-japan
#6
Kazutoshi Fujibayashi, Michio Hayashi, Hirohide Yokokawa, Toshio Naito
BACKGROUND: We examined the long-term changes in the management of diabetes at a single institution in Japan. METHODS: Two repeated cross-sectional studies and a retrospective cohort study were conducted among patients who visited our institution between 2001 and 2013. We examined the changes in glycated hemoglobin (HbA1c) and glycated albumin levels, the prescription frequencies, and the daily doses of each antidiabetic agent among patients treated regularly for diabetes during the 13-year study period...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27833664/factors-that-could-explain-the-increasing-prevalence-of-type-2-diabetes-among-adults-in-a-canadian-province-a-critical-review-and-analysis
#7
REVIEW
Véronique Thibault, Mathieu Bélanger, Emilie LeBlanc, Lise Babin, Stuart Halpine, Beverly Greene, Michelina Mancuso
BACKGROUND: The prevalence of diabetes has increased since the last decade in New Brunswick. Identifying factors contributing to the increase in diabetes prevalence will help inform an action plan to manage the condition. The objective was to describe factors that could explain the increasing prevalence of type 2 diabetes in New Brunswick since 2001. METHODS: A critical literature review was conducted to identify factors potentially responsible for an increase in prevalence of diabetes...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27757172/trends-in-the-prevalence-of-self-reported-diabetes-in-brazilian-capital-cities-and-the-federal-district-2006-2014
#8
Betine Pinto Moehlecke Iser, Álvaro Vigo, Bruce Bartholow Duncan, Maria Inês Schmidt
BACKGROUND: Diabetes is increasing globally, particularly in low and middle income countries, posing a great challenge to health systems. Brazil is currently ranked 4th in the world in terms of the absolute number of persons with diabetes. Our aim was to analyze the trend in self-reported diabetes prevalence between 2006 and 2014 in Brazilian adults. METHODS: We used data from the national telephone survey-VIGITEL. Over 40,000 individuals from probabilistic sample of subjects ≥18 years old residing in 26 state capitals and the Federal District were interviewed per year in each location...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27660663/insulin-lispro-low-mixture-twice-daily-vs-basal-insulin-glargine-once-daily-and-prandial-insulin-lispro-once-daily-as-insulin-intensification-strategies-in-patients-with-type-2-diabetes-latin-american-subpopulation-analysis-of-a-randomized-trial
#9
Arturo Rojas, Georgina Sposetti, Jorge L Gross, Douglas Eugenio Barbieri, Ran Duan, Bruno Linetzky, Janaina Martins De Lana, Oded Stempa, Angel Rodriguez
BACKGROUND: This post hoc analysis examined the efficacy and safety of twice-daily insulin lispro low mixture (LM25) and once-daily basal insulin glargine plus once-daily prandial insulin lispro (IGL) in a Latin American subpopulation with type 2 diabetes mellitus (T2DM). METHODS: A phase 4, randomized, open-label, parallel-arm trial included participants aged 18-75 years with T2DM taking once-daily insulin glargine and stable doses of metformin and/or pioglitazone with glycated hemoglobin (HbA1c) 7...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27651836/maternal-adipokines-and-insulin-as-biomarkers-of-pregnancies-complicated-by-overweight-and-obesity
#10
Joice Monaliza Vernini, Jusciéle Brogin Moreli, Roberto Antônio Araújo Costa, Carlos Antonio Negrato, Marilza Vieira Cunha Rudge, Iracema Mattos Paranhos Calderon
BACKGROUND: Maternal obesity is associated with several adverse pregnancy outcomes. This study was conducted aiming to evaluate maternal levels of adipokines and insulin in pregnancies complicated by overweight and obesity and its correlations with maternal and fetal outcomes. METHODS: This cross-sectional study included 72 mother-newborn pairs. Mothers were classified as having normal weight (n = 23), overweight (n = 18), and obesity (n = 31). Maternal adiponectin, leptin, resistin and insulin levels at the end of pregnancy were compared among groups and correlated with maternal and perinatal outcomes...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27625707/the-c1431t-polymorphism-of-peroxisome-proliferator-activated-receptor-%C3%AE-ppar%C3%AE-is-associated-with-low-risk-of-diabetes-in-a-pakistani-cohort
#11
Huma Butt, Shabana, Shahida Hasnain
BACKGROUND: Diabetes is a socioeconomic burden in Pakistan. International diabetes federation reported 6.9 million cases of diabetes and 87,548 deaths due to diabetes in Pakistan in 2014. Peroxisome proliferators-activated receptors are transcription factors, regulating several physiological processes. AIM: The aim of the current study was to determine the prevalence of silent variant C1431T in exon 6 of PPAR-y and analyze its effect on various anthropometric and biochemical parameters in a Pakistani cohort...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27625706/brazilian-multicenter-study-for-the-evaluation-of-patients-satisfaction-of-blood-glucose-self-monitoring-with-bgstar-%C3%A2-blood-glucose-meter-in-insulinized-patients-with-diabetes-mellitus-type-1-and-2
#12
Miguel Nasser Hissa
BACKGROUND: Diabetes mellitus (DM) is considered a global epidemic, and patient self-management education and support are critical in preventing and reducing the risk of complications. Self-monitoring of blood glucose (SMBG) is essential for care of individuals with DM, helping patients to achieve and maintain target blood glucose levels. The purpose of this study is to compare the satisfaction of insulinized DM patients on SMBG with use of investigational blood glucose meter (BGM) versus their routine device...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27610204/prevalence-of-diabetes-in-brazil-over-time-a-systematic-review-with-meta-analysis
#13
REVIEW
Gabriela H Telo, Felipe Vogt Cureau, Martina S de Souza, Thais S Andrade, Fabiana Copês, Beatriz D Schaan
Diabetes is one of the most important epidemic diseases of this century and the number of people with diabetes has more than doubled over the past three decades. Our aim was to estimate the prevalence of diabetes in the adult Brazilian population and analyze the trends for the last three decades through a systematic review with meta-analysis. This review included observational studies published between 1980 and 2015, which were independently identified by two reviewers in five databases. Random effect models were used to estimate the prevalence and trends of diabetes...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27602060/impact-of-longitudinal-status-change-in-metabolic-syndrome-defined-by-two-different-criteria-on-new-onset-of-type-2-diabetes-in-a-general-japanese-population-the-tanno-sobetsu-study
#14
Hirofumi Ohnishi, Shigeyuki Saitoh, Hiroshi Akasaka, Tetsuaki Furukawa, Mitsuru Mori, Tetsuji Miura
BACKGROUND: We investigated the effect of longitudinal status change in metabolic syndrome (MetS) assessed by two different criteria on new onset of type 2 diabetes (NODM) in a Japanese population. METHODS: The participants were 827 non-diabetic citizens who had undergone medical examinations in 1994 and 2003 or 2004. We used two different criteria of MetS: the interim criteria by 6 institutions (MetS-INT) and Japanese criteria (MetS-JP). According to the interim criteria, individuals defined as having MetS have any three of the following five components of MetS: obesity, hyperglycemia, high blood pressure, hypertriglyceridemia and low HDL cholesterolemia...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27583022/skin-disorders-in-diabetes-mellitus-an-epidemiology-and-physiopathology-review
#15
REVIEW
Geisa Maria Campos de Macedo, Samanta Nunes, Tania Barreto
Skin disorders, usually neglected and frequently underdiagnosed among diabetic patients, are common complications and encounter a broad spectrum of disorders in both type 1 and type 2 diabetes mellitus (DM)-e.g. cutaneous infection, dry skin, pruritus. Skin disorders are highly associated with increased risk of important outcomes, such as skin lesions, ulcerations and diabetic foot, which can lead to major complications and revolve around multifactorial factors besides hyperglycemia and advanced glycation end products...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27579145/fasting-plasma-glucose-concentrations-for-specified-hba1c-goals-in-korean-populations-data-from-the-fifth-korea-national-health-and-nutrition-examination-survey-knhanes-v-2-2011
#16
Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm
AIMS: To examine the correlation between the fasting plasma glucose and HbA1c levels using regression equation and to assess the average fasting plasma glucose levels for the specific HbA1c (A1C) goals in the patients with diabetes using each A1C-and fasting plasma glucose-based diagnostic criteria. METHODS: This study included data from 4481 participants with A1C and fasting plasma glucose, but with no diabetic medications in the Korean National Health and Nutritional Examination Survey 2011...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27570545/early-diabetes-screening-in-women-with-previous-gestational-diabetes-a-new-insight
#17
Aline Nabuco, Samara Pimentel, Carolina A Cabizuca, Melanie Rodacki, Denise Finamore, Marcus M Oliveira, Lenita Zajdenverg
BACKGROUND: Gestational diabetes mellitus (GDM) is a risk factor for the development of diabetes mellitus (DM). However, there is a low return rate for this screening, so it is important to search for earlier methods for evaluation after delivery, to increase the number of pregnant women screened, so you can start the treatment or prevention of these early comorbidities. To determine the accuracy of the 75 g 2-h oral glucose tolerance test (OGTT) performed between 48-72 h after delivery for the diagnosis of DM using the OGTT after 6 weeks as the gold standard criterion, and to identify the optimal cutoff points for this exam for diabetes screening after a pregnancy complicated by GDM...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27563355/%C3%AE-cell-death-is-decreased-in-women-with-gestational-diabetes-mellitus
#18
Lauren A Kenna, John A Olsen, Michael G Spelios, Michael S Radin, Eitan M Akirav
BACKGROUND: Gestational diabetes mellitus (GDM) affects approximately 7-17 % of all pregnancies and has been recognized as a significant risk factor to neonatal and maternal health. Postpartum, GDM significantly increases the likelihood of developing type 2 diabetes (T2D). While it is well established that insulin resistance and impaired β-cell function contribute to GDM development, the role of active β-cell loss remains unknown. Differentially methylated circulating free DNA (cfDNA) is a minimally invasive biomarker of β-cell loss in type 1 diabetes mellitus...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27559364/the-impact-of-the-metabolic-phenotype-on-thyroid-function-in-obesity
#19
Paolo Marzullo, Chiara Mele, Stefania Mai, Gabriele Guzzaloni, Davide Soranna, Maria Antonella Tagliaferri, Maria Elisa Berselli, Flavia Prodam, Daniela Surico, Gianluca Aimaretti, Massimo Scacchi
BACKGROUND: Obesity is known to promote mild hyperthyrotropinaemia by unknown metabolic mechanisms. This investigation aimed to explore the association between thyroid function and metabolic phenotype in euthyroid obese individuals. Retrospective, cross-sectional study. Tertiary care center. METHODS: 952 euthyroid obese individuals referred to our Institution for obesity. Serum levels of TSH, FT4, glucose, insulin and HbA1c levels, lipid profile, liver function and proinflammatory indices were measured...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27559363/dietary-factors-associated-with-metabolic-syndrome-and-its-components-in-overweight-and-obese-brazilian-schoolchildren-a-cross-sectional-study
#20
Ana Elisa Madalena Rinaldi, Gleice Fernanda Costa Pinto Gabriel, Fernando Moreto, José Eduardo Corrente, Kátia Cristina Portero McLellan, Roberto Carlos Burini
BACKGROUND: The metabolic syndrome (MS) has been assessed since childhood mainly because of the nutritional and epidemiological transition that has occurred worldwide. Our objectives were to explore the MS and its components according to anthropometric and demographic factors and to assess the relationship among MS components and dietary characteristics in overweight and obese schoolchildren. METHODS: This was a cross-sectional study which included 147 schoolchildren (aged 6-10 years) from three elementary schools, with body mass index (BMI) higher than the 85th percentile...
2016: Diabetology & Metabolic Syndrome
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