Tridip Mitra, Richa Gulati, Krithika Ramachandran, Rohan Rajiv, Elizabeth Ann L Enninga, Chris K Pierret, Sajeetha Kumari R, Rajiv Janardhanan
Gestational Diabetes Mellitus (GDM) has been on the rise for the last two decades along with the growing incidence of obesity. The ubiquitous use of Endocrine-Disrupting Chemicals (EDCs) worldwide has been associated with this increase in GDM incidence. Epigenetic modifications such as DNA methylation, histone acetylation, and methylation have been associated with prenatal exposure to EDCs. EDC exposure can also drive a sustained disruption of the hypothalamus-pituitary-thyroid axis and various other signaling pathways such as thyroid signaling, PPARγ signaling, PI3K-AKT signaling...
April 26, 2024: Diabetology & Metabolic Syndrome