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Diabetology & Metabolic Syndrome

Jun Watanabe, Eiichi Kakehi, Kazuhiko Kotani, Kazunori Kayaba, Yosikazu Nakamura, Shizukiyo Ishikawa
Background: Metabolic syndrome (MetS) and cancer are major public health problems worldwide. The relationship between MetS and cancer death is of great interest. We examined the predictive value of MetS for cancer mortality in Japan. Methods: Study participants included 4495 men and 7028 women aged 18-90 years who were registered between 1992 and 1995 as part of the Jichi Medical School Cohort Study. We used a definition of MetS modified for the Japanese population...
2019: Diabetology & Metabolic Syndrome
Karla F S Melo, Luciana R Bahia, Bruna Pasinato, Gustavo J M Porfirio, Ana Luiza Martimbianco, Rachel Riera, Luis E P Calliari, Walter J Minicucci, Luiz A A Turatti, Hermelinda C Pedrosa, Beatriz D Schaan
Introduction: Strict glucose control using multiple doses of insulin is the standard treatment for type 1 diabetes mellitus (T1DM), but increased risk of hypoglycemia is a frequent drawback. Regular insulin in multiple doses is important for achieving strict glycemic control for T1DM, but short-acting insulin analogues may be better in reducing hypoglycemia and postprandial glucose levels. Objective: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effects of short-acting insulin analogues vs regular human insulin on hypoglycemia and postprandial glucose in patients with T1DM...
2019: Diabetology & Metabolic Syndrome
Cecília Pacheco Elias, Daniela Espíndola Antunes, Michella Soares Coelho, Caroline Lourenço de Lima, Nelson Rassi, Ana Paula Meireles de Melo, Angélica Amorim Amato
Background: Familial partial lipodystrophy (FPL) is a rare genetic disease characterized by body fat abnormalities that lead to insulin resistance (IR). Clinical conditions linked to milder IR, such as type 2 diabetes (T2D) and metabolic syndrome, are associated with abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis, but little is known about its activity in FPL. Methods: Patients meeting the clinical criteria for FPL were subjected to anthropometric, biochemical and hormone analyses...
2019: Diabetology & Metabolic Syndrome
Sachiko Hattori
Background: Inflammation might be a pathological mediator of cardiovascular events in patients with type 2 diabetes and high cardiovascular risk. Methods: We investigated whether empagliflozin (EMPA) exerts anti-inflammatory effects that are reflected in decreased high-sensitivity C-reactive protein (hsCRP) values. Patients were allocated to receive a placebo (n = 51) or EMPA (n = 51) as an add-on treatment. Fasting blood samples were collected before and every 3 months after this intervention for 1 year...
2018: Diabetology & Metabolic Syndrome
Wen-Qiang Zhang, Yuan Tian, Xiao-Min Chen, Li-Fen Wang, Chan-Chan Chen, Chuan-Mei Qiu
Background: The prevalence of type 2 diabetes in youth is escalating rapidly. We aimed to evaluate the effects of liraglutide on beta-cell function, metabolic productions of oxidative stress, low grade inflammation compared with metformin in young patients with recent onset type 2 diabetes mellitus. Methods: Sixty patients were randomly assigned to receive 8-week liraglutide or metformin treatment. Beta-cell function was assessed by modified beta cell function index (MBCI), early phase of insulin secretion index (ΔI30/ΔG30), proinsuin to insulin ratio (P/I) and the insulin area under the curve (AUCins)...
2018: Diabetology & Metabolic Syndrome
Ramy H Bishay, Gideon Meyerowitz-Katz, David Chandrakumar, Rajini Jayaballa, Tien-Ming Hng, Mark Mclean, Dilini Punchihewa, Maiyoori Jeyaprakash, David Burgess, John Riskallah, Glen F Maberly
Background: Approximately two-thirds of individuals presenting to emergency departments in Western Sydney have glucose dysregulation, accelerating their risk of cardiovascular disease (CVD). We evaluated the prevalence and management of type 2 diabetes (T2D) in cardiology inpatients in Western Sydney. A novel model of care between diabetes and cardiology specialist hospital teams (joint specialist case conferencing, JSCC) is described herein and aimed at aligning clinical services and upskilling both teams in the management of the cardiology inpatient with comorbid T2D...
2018: Diabetology & Metabolic Syndrome
Waleed A Mohamed, Mona F Schaalan
The current study aims to investigate the antidiabetic efficacy of camel milk-derived lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling pathway in obese diabetic pediatric population. Sixty young obese patients with type 2 diabetes were selected from the Pediatric Endocrine Metabolic Unit, Cairo University and were randomly divided among two age and sex-matched groups so as to receive either standard therapy without lactoferrin in one arm or to be treated with oral lactoferrin capsules (250 mg/day, p...
2018: Diabetology & Metabolic Syndrome
Eri Amano, Shogo Funakoshi, Kumiko Yoshimura, Seiki Hirano, Satoko Ohmi, Hiroshi Takata, Yoshio Terada, Shimpei Fujimoto
Background: Recently, an integrated network analysis has revealed dysregulation in the metabolism of mannose, a glucose epimer, in severely obese individuals without diabetes. In addition, fasting plasma mannose levels (M0 ) are associated with insulin resistance independent of BMI. Since the association between mannose and insulin sensitivity (IS) in those with impaired glucose tolerance remains unknown, we aimed to investigate this association in individuals without severe obesity but with varying degrees of glucose tolerance...
2018: Diabetology & Metabolic Syndrome
Mahmood Karimy, Hamid Reza Koohestani, Marzieh Araban
Objectives: Diabetes is a chronic illness which requires lifelong self-care behaviors. The objective of the present research was to investigate the association of self-efficacy, attitude and social support with adherence to diabetes self-care behavior. Materials and methods: In this cross-sectional study conducted in 2017, 403 diabetic patients of Zarandieh, Iran participated. They were evaluated by valid and reliable questionnaires comprised of items on diabetes self-care, self-efficacy in dealing with problems, social support and attitude towards self-care...
2018: Diabetology & Metabolic Syndrome
Stephanie Kulhawy-Wibe, Kathryn M King-Shier, Cheryl Barnabe, Braden J Manns, Brenda R Hemmelgarn, David J T Campbell
Background: Type 2 diabetes is highly prevalent in Canadian First Nations (FN) communities. FN individuals with diabetes are less likely to receive guideline recommended care and access specialist care. They are also less likely to be able to engage in optimal self-management behaviours. While the systemic and racial contributors to this problem have been well described, individuals' experiences with structural barriers to care and self-management remain under-characterized. Methods: We utilized qualitative methods to gain insight into the structural barriers to self-management experienced by FN individuals with diabetes...
2018: Diabetology & Metabolic Syndrome
Luis Eduardo Calliari, Laura Cudizio, Balduino Tschiedel, Hermelinda C Pedrosa, Rosangela Rea, Augusto Pimazoni-Netto, Laurence Hirsch, Kenneth Strauss
Background: In 2014-2015, the largest international survey of insulin injection technique in patients with diabetes taking insulin was conducted in 42 countries, totaling 13,289 participants. In Brazil, patients from five public health centers were included. This study aims to evaluate insulin injection technique in Brazilian patients and compare results with Latin America (LatAm) and World data. Methods: The insulin Injection Technique Questionnaire (ITQ) survey consisted of an initial patient section (questions applied by an experienced nurse), followed by observation of injection technique and examination of the injection sites by the health care professional...
2018: Diabetology & Metabolic Syndrome
Kiyuri Naicker, Douglas Manuel, Simon Øverland, Jens C Skogen, Jeffrey A Johnson, Børge Sivertsen, Ian Colman
Background: Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk factor combinations, including the metabolic syndrome, behavioural factors, and specifically, depression and anxiety. Methods: Using data from the population-based HUNT cohort, we examined incident diabetes in 36,161 Norwegian adults from 1995 to 2008...
2018: Diabetology & Metabolic Syndrome
Rodrigo Nunes Lamounier, Bruno Geloneze, Silmara Oliveira Leite, Renan Montenegro, Lenita Zajdenverg, Milene Fernandes, Fabiano de Oliveira Griciunas, Mariana Narbot Ermetice, António Roberto Chacra
Background: Hypoglycemia affects patient safety and glycemic control during insulin treatment of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). The Hypoglycemia Assessment Tool study in Brazil aimed to determine the proportion of patients experiencing hypoglycemic events and to characterize patient awareness and fear about hypoglycemia, among insulin-treated T1DM or T2DM patients. Methods: This was a non-interventional, multicenter study, with a 6-month retrospective and a 4-week prospective evaluation of hypoglycemic events...
2018: Diabetology & Metabolic Syndrome
B Almeida-Pititto, I T Silva, A C Goulart, M I H Fonseca, M S Bittencourt, R D Santos, M Blaha, S Jones, P P Toth, K Kulakarni, P A Lotufo, I M Bensenor, S R G Ferreira
Background: Neck circumference (NC) is associated with traditional cardiovascular risk factors (CVRF), but its usefulness to identify earlier atherogenic risk has been scarcely examined. Associations of NC with non-traditional CVRF were investigated in participants at low-to-moderate risk from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: 807 individuals (35-54 years) without obesity, diabetes or cardiovascular disease was stratified into quartiles of NC (cut-off for men: 36...
2018: Diabetology & Metabolic Syndrome
João Soares Felício, Lilian de Souza d'Albuquerque Silva, Carlliane Lima E Lins Pinto Martins, João Felício Abrahão Neto, Manuela Nascimento de Lemos, Fabrício de Souza Resende, Wanderson Maia da Silva, Angélica Leite de Alcântara, Maria Clara Neres Iunes de Oliveira, Norberto Jorge Kzan de Souza Neto, Isabela Imbelloni Farias de Franco, Nathalie Abdallah Zahalan, Luísa Correa Janaú, Ana Carolina Contente Braga de Souza, Flavia Marques Santos, Natércia Neves Marques de Queiroz, Neyla Arroyo Lara Mourão, Márcia Costa Dos Santos, Karem Miléo Felício, Franciane Trindade Cunha de Melo
Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoacoustic emissions (OAEs) is useful to identify subclinical cochlear dysfunction. Therefore, the aim of this study was to evaluate the association between abnormal OAEs responses, diabetic kidney disease (DKD) and diabetic cardiac autonomic neuropathy (CAN). We performed a cross-sectional study with 37 type 1 DM patients without auditory symptoms, submitted to the study of Distortion Product Otoacoustic Emissions (DPOAEs) and screened for DKD and CAN...
2018: Diabetology & Metabolic Syndrome
Halgord Ali M Farag, Mohammad Javad Hosseinzadeh-Attar, Belal A Muhammad, Ahmad Esmaillzadeh, Abdel Hamid El Bilbeisi
Objective: Vitamin D and C levels have inverse relation with the metabolic syndrome components and they are used as antioxidant supplements during enduring metabolic activities. In the present study, we hypothesized that the intake of vitamin D and/or C with endurance physical activity might reduce the risk of metabolic syndrome. Methods: A randomized control study recruited 180 participants of both genders, aged between 30 and 50 years. The participants were assigned into six groups receiving different doses of vitamin D or vitamin C with or without physical activities...
2018: Diabetology & Metabolic Syndrome
Ming-Sheng Teng, Semon Wu, Leay-Kiaw Er, Lung-An Hsu, Hsin-Hua Chou, Yu-Lin Ko
Background: Visceral adiposity indicators and the product of triglyceride and fasting plasma glucose (TyG) index-related parameters are effective surrogate markers for insulin resistance (IR) and are predictors of metabolic syndrome and diabetes mellitus. However, their genetic determinants have not been previously reported. Pleiotropic associations of LIPC variants have been observed in lipid profiles and atherosclerotic cardiovascular diseases. We aimed to investigate LIPC polymorphisms as the genetic determinants of adiposity status, visceral adiposity indicators and TyG index-related parameters...
2018: Diabetology & Metabolic Syndrome
Zeinab Hemati, Nafiseh Mozafarian, Ramin Heshmat, Zeinab Ahadi, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Tahereh Aminaee, Mostafa Qorbani, Roya Kelishadi
Objective: This study aims to evaluate the association of sleep duration with metabolic syndrome (MetS) and its components in a pediatric population. Methods: This multi-centric cross-sectional study was conducted in 2015 in 30 provinces of Iran. Participants consisted of 4200 school students aged 7-18 years, studied in a national school-based surveillance program (CASPIAN-V). Physical examinations and laboratory tests were performed using standard protocols. The analysis was conducted based on the propensity score matching and conditional logistic regression was used to evaluate the association of short sleep (less than 8 h a day) and the onset of sleep with MetS and its components...
2018: Diabetology & Metabolic Syndrome
Marcelo Alves Alvarenga, William Ricardo Komatsu, Joao Roberto de Sa, Antonio Roberto Chacra, Sergio Atala Dib
Background: Clinical inertia is related to the difficulty of achieving and maintaining optimal glycemic control. It has been extensively studied the delay of the period to insulin introduction in type 2 diabetes mellitus (T2DM) patients. This study aims to evaluate clinical inertia of insulin treatment intensification in a group of T2DM patients followed at a tertiary public Diabetes Center with limited pharmacologic armamentarium (Metformin, Sulphonylurea and Human Insulin). Methods: This is a real life retrospective record based study with T2DM patients...
2018: Diabetology & Metabolic Syndrome
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