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Food & Nutrition Research

Maria Grorud Fagerhøi, Silvia Rollefstad, Sissel Urke Olsen, Anne Grete Semb
Background: Patients with inflammatory joint diseases (IJD) have an increased risk of cardiovascular disease (CVD) compared to the general population. Nutritional advice has been shown to influence CVD risk factors. Our objective was to evaluate whether an individually tailored dietary counselling versus a brief standardised advice on heart-friendly diet had comparable effect on change in diet, lipids and blood pressure (BP) in patients with IJD. Methods: Thirty-one patients with IJD aged 40-80 years received a brief standardised advice (4 min) on heart-friendly diet by a physician...
2018: Food & Nutrition Research
Lotta Moraeus, Eva Warensjö Lemming, Ulla-Kaisa Koivisto Hursti, Marianne Arnemo, Jessica Petrelius Sipinen, Anna-Karin Lindroos
Background: Nationally representative information on food consumption data is essential to evaluate dietary habits, inform policy-making and nutritional guidelines, as well as forming a basis for risk assessment and identification of risk groups. Objective: To describe the methods used in the Swedish national dietary survey of adolescents, Riksmaten Adolescents 2016-2017. Design: Students in grades 5, 8, and 11 (mean ages 12, 15, and 18 years) were recruited in this school-based cross-sectional survey...
2018: Food & Nutrition Research
Ui-Jin Bae, Eun-Soo Jung, Su-Jin Jung, Soo-Wan Chae, Byung-Hyun Park
Background: Augmenting glucose utilization in skeletal muscle via the phosphatidylinositol-3 kinase (PI3 kinase)/protein kinase B (Akt) pathway or the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway is necessary to regulate hyperglycemia in patients with type 2 diabetes mellitus. Objective: We investigated the effect of mulberry leaf extract (MLE) on glucose uptake in skeletal muscle cells and explored its in vivo antidiabetic potential. Design: Male db/db mice were treated with either MLE (50 mg/kg, 100 mg/kg, and 250 mg/kg) or metformin (100 mg/kg) for 8 weeks...
2018: Food & Nutrition Research
Alessandro Attanzio, Luisa Tesoriere, Sonya Vasto, Anna Maria Pintaudi, Maria A Livrea, Mario Allegra
Background: Dietary ingredients and food components are major modifiable factors protecting immune system and preventing the progression of a low-grade chronic inflammation responsible for age-related diseases. Objective: Our study explored whether cactus pear ( Opuntia ficus-indica , Surfarina cultivar) fruit supplementation modulates plasma inflammatory biomarkers in healthy adults. Correlations between inflammatory parameters and antioxidant status were also assessed in parallel...
2018: Food & Nutrition Research
Elisabet R Hillesund, Elling Bere, Linda R Sagedal, Ingvild Vistad, Hilde L Seiler, Monica K Torstveit, Nina C Øverby
Background: Randomized controlled trials targeting maternal dietary and physical activity behaviors during pregnancy have generally failed to accomplish reductions in the prevalence of adverse maternal and neonatal outcomes. Interventions carried out during pregnancy could thus be missing the mark in maximizing intervention health benefit. Objective: To investigate whether pre-pregnancy and early pregnancy dietary behavior as reported at inclusion into the Norwegian Fit for Delivery (NFFD) trial was associated with maternal and neonatal outcomes irrespective of subsequent randomization assignment...
2018: Food & Nutrition Research
Anne Dahl Lassen, Sisse Fagt, Maria Lennernäs, Maria Nyberg, Irja Haapalar, Anne V Thorsen, Anna C M Møbjerg, Anne M Beck
We conducted a systematic review of randomised studies on the impact of worksite interventions to promote healthier food and/or physical activity among people who work irregular hours 'around the clock', that is, outside of ordinary daytime working hours. The population-intervention-comparator-outcomes-study (PICOS) design format was used. Data sources were PubMed and CINAHL. An updated search was conducted on October 2017 using Google Scholar and the related articles function in PubMed on initially included studies to identify additional studies...
2018: Food & Nutrition Research
Yue-Hong Lu, Cheng-Rui Tian, Chun-Yan Gao, Wen-Jing Wang, Wen-Yi Yang, Xiao Kong, You-Xia Chen, Zhen-Zhen Liu
Protective effect of free phenolics from Lycopus lucidus Turcz. root (FPLR) on CCl4 -induced hepatotoxicity in vivo and in vitro was first evaluated. Oral administration of FPLR (100 mg/kg bw) to mice significantly reduced the CCl4 -induced elevation of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, triacylglycerols, total cholesterol, and total bilirubin. FPLR also increased the hepatic GSH contents and antioxidant enzyme activities of SOD and CAT and decreased the hepatic MDA level...
2018: Food & Nutrition Research
Siyuan Chen, Yaoyao Xia, Guoqiang Zhu, Jiameng Yan, Chengquan Tan, Baichuan Deng, Jinping Deng, Yulong Yin, Wenkai Ren
Background: Intestinal stem cells can be differentiated into absorptive enterocytes and secretory cells, including Paneth cells, goblet cells, and enteroendocrine cells. Glutamine is a primary metabolic fuel of small intestinal enterocytes and is essential for the viability and growth of intestinal cells. Objective: Whether glutamine supplementation affects the differentiation of intestinal stem cells is unknown. Design: Three-week-old ICR (Institute of Cancer Research) male mice were divided randomly into two groups: 1) mice receiving a basal diet and normal drinking water and 2) mice receiving a basal diet and drinking water supplemented with glutamine...
2018: Food & Nutrition Research
Priscilia Lianto, Fredrick O Ogutu, Yani Zhang, Feng He, Huilian Che
Background: Quail egg (QE) has been reported to possess an anti-allergic and anti-inflammatory activity. We have demonstrated that whole QE was able to attenuate the allergic symptoms in food allergy-induced EoE murine model, but whether QE albumen or QE yolk plays a more important role still remains unclear. Objective: In this current study, we investigated the suppressive role of QE in mast cell degranulation and cytokine production of the effect phase response...
2018: Food & Nutrition Research
Wenbo Ye, Liang Liu, Juan Yu, Shilin Liu, Qiang Yong, Yimin Fan
Partially deacetylated α-chitin nanofibers/nanowhiskers mixtures (DEChNs) were prepared by 35% sodium hydroxide (NaOH) treatment followed by disintegration in water at pH 3-4. The aim of this study was to investigate the hypolipidemic effects of DEChNs at different dosage levels in male Kunming mice. The male mice were randomly separated into five groups, that is, a normal diet group, a high-fat diet group, and three DEChN groups that were treated with different doses of DEChN dispersions (L: low dose, M: medium dose, H: high dose)...
2018: Food & Nutrition Research
Chenyan Lv, Yifei Wang, Cui Zhou, Weiwei Ma, Yuexin Yang, Rong Xiao, Huanling Yu
Background: Dietary saturated fatty acids are always being hotly debated. Palm olein rich in saturated fatty acids (45.98%) is often considered as being atherogenic nutritionally. There is a lack of information on effects of dietary oil by partially replacing with palm olein on human health. Methods: A randomized controlled trial with 88 participants has been conducted to elucidate the effect of palm olein on cardiovascular risk factors. Results: By comparing the soybean oil group (saturated fatty acids amounted to 23...
2018: Food & Nutrition Research
Yueyue Meng, Bailiang Li, Da Jin, Meng Zhan, Jingjing Lu, Guicheng Huo
Background: Probiotics in fermented foods have attracted considerable attention lately as treatment options for immune diseases, the incidence of which has been increasing throughout the world. Objective: The objective of the present study was to investigate the immunomodulatory activity of Lactobacillus plantarum ( L. plantarum ) KLDS1.0318 in cyclophosphamide-treated mice. Design: To investigate the immune-enhancing effects of L. plantarum KLDS1...
2018: Food & Nutrition Research
Igor Sukhotnik, Dalia Moati, Ron Shaoul, Boaz Loberman, Yulia Pollak, Betty Schwartz
Background: Gastrointestinal mucositis occurs as a consequence of cytotoxic treatment. Quercetin (QCT) is a bioflavonoid that exerts significant antioxidant activity and anti-inflammatory as well as anti-malignancy properties. Objective: To evaluate the effects of oral QCT consumption in preventing intestinal mucosal damage and stimulating intestinal recovery following methotrexate (MTX)-induced intestinal damage in a rat model. Design: Male Sprague-Dawley rats were divided into four groups: Control Group A (CONTR) - rats were treated with 2 cc of saline given by gavage for 6 days...
2018: Food & Nutrition Research
Hwa Joung Lee, Rihua Cui, Sung-E Choi, Ja Young Jeon, Hae Jin Kim, Tae Ho Kim, Yup Kang, Kwan-Woo Lee
Background: Bitter melon (BM) improves glucose level, lipid homeostasis, and insulin resistance in vivo . However, the preventive mechanism of BM in nonalcoholic fatty liver disease (NAFLD) has not been elucidated yet. Aim & Design: To determine the protective mechanism of bitter melon extract (BME), we performed experiments in vitro and in vivo . BME were treated palmitate (PA)-administrated HepG2 cells. C57BL/6J mice were divided into two groups: high-fat/high-fructose (HF/HFr) without or with BME supplementation (100 mg/kg body weight)...
2018: Food & Nutrition Research
Minxian Rong, Pei Wang, Yuesheng Qiu, Yungang Liu, Yiyuan Wang, Hong Deng
Introduction: Owing to the contamination of chemical pollutants, especially nitrosamines and their precursors, in Chinese sausage, long-term intake of Chinese sausage may have potential health effects. Objection: This study investigated the effects of long-term intake of Chinese sausage with different contaminations of N -nitrosodimethylamine (NDMA) on rat liver and the potential biomarkers in the serum. Methods: Serum metabolomic analysis was performed by gas chromatography-mass spectrometry at weeks 7, 17, 25, and 33; simultaneously, liver histopathological examination was conducted and its relationship with the serum metabolomics was also investigated...
2018: Food & Nutrition Research
Muhammed Majeed, Kalyanam Nagabhushanam, Sivakumar Arumugam, Shaheen Majeed, Furqan Ali
Background: The modification of microbial ecology in human gut by supplementing probiotics may be an alternative strategy to ameliorate or prevent depression. Objective: The current study was conducted to assess the safety and efficacy of the probiotic strain Bacillus coagulans MTCC 5856 for major depressive disorder (MDD) in IBS patients. Method: Patients ( n = 40) diagnosed for MDD with IBS were randomized (1:1) to receive placebo or B. coagulans MTCC 5856 at a daily dose of 2 × 109 cfu (2 billion spores) and were maintained to the end of double-blind treatment (90 days)...
2018: Food & Nutrition Research
Liang Shen, Hui-Hui Jiang, Hong-Fang Ji
Background: As the major active component of turmeric (Curcuma longa), curcumin is widely used as a spice and food coloring agent, and also possesses multiple biological activities and therapeutic potential for neurodegenerative diseases. To answer the paradox between curcumin's biological activities and poor systemic bioavailability, we proposed that degradation products of curcumin may make important contributions to its biological activities, which needs to be verified. In addition, curcumin is usually heated or boiled used as a spice, it is necessary to explore whether boiled curcumin, which degrades readily, is still biologically active...
2018: Food & Nutrition Research
Susan G Woods, Allen Knehans, Sandra Arnold, Carol Dionne, Leah Hoffman, Peggy Turner, Jonathan Baldwin
Background: Research on aging in Prader-Willi syndrome (PWS) is limited, although people with PWS are living longer. Individuals with PWS present with high fat mass, low lean mass, and low levels of physical activity (PA). Previous reports in children and young adults with PWS show inadequate nutrient intake and body fat percentage indicating obesity. Previous studies in PWS rarely included individuals beyond young adulthood, especially studies conducted in the United States. This study includes adults from 18 to 62 years of age, and includes 19 of the estimated 60 adult individuals with PWS in Oklahoma...
2018: Food & Nutrition Research
Yao Jiang, Chuhan Fu, Guihua Liu, Jiao Guo, Zhengquan Su
Background: Chitooligosaccharide (COS) has shown potential antihyperlipidemic activity in a few studies as a functional food. Method: We investigated the cholesterol-lowering effect and potential mechanisms of chitooligosaccharide capsules (COSTC) in male SD rats fed a high-fat diet. Results: COSTC could ameliorate serum lipid levels. Simultaneously, the cholesterol-lowering effect is probably attributed to its role in two pathways: upregulating the gene expression and activity of cholesterol 7α-hydroxylase (CYP7A1), liver X receptor alpha (LXRA), and peroxisome proliferation activated receptor-α (PPARα), which facilitates the conversion of cholesterol into bile acid; downregulating the gene expression and activity of enzymes including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and sterol-responsive element binding protein-2 (SREBP2) and upregulating the low-density lipoprotein receptor (LDLR) to reduce the denovo synthesis of cholesterol...
2018: Food & Nutrition Research
Liu Xianchu, Liu Ming, Liu Xiangbin, Zheng Lan
Background: Grape seed proanthocyanidin extract (GSPE) has been extensively reported to possess a wide range of beneficial properties in multiple tissue damage. Previous studies have shown that exhaustive exercise-induced fatigue associates with oxidative stress injury, inflammatory response, and mitochondrial dysfunction. Objective: The aim of this study is to investigate the anti-fatigue effects of GSPE in mice and explore its possible underlying mechanism. Design: The mouse model of exhaustive exercise-induced fatigue was established by using the forced swimming test, and GSPE was orally treated for successive 28 days at 0, 1, 50 and 100 mg/kg/day of body weight, designated the control, GSPE-L, GSPE-M and GSPE-H groups, respectively...
2018: Food & Nutrition Research
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