Monica Butnariu, Cristina Quispe, Javad Sharifi-Rad, Eduardo Pons-Fuster, Pia Lopez-Jornet, Wissam Zam, Tuyelee Das, Abhijit Dey, Manoj Kumar, Marius Pentea, Ali H Eid, Almagul Umbetova, Jen-Tsung Chen
Oral cancer (OC) is the eighth most common cancer, particularly prevalent in developing countries. Current treatment includes a multidisciplinary approach, involving chemo, radio, and immunotherapy and surgery, which depends on cancer stage and location. As a result of the side effects of currently available drugs, there has been an increasing interest in the search for naturally-occurring bioactives for treating all types of cancer, including OC. Thus, this comprehensive review aims to give a holistic view on OC incidence and impact, while highlights the preclinical and clinical studies related to the use of medicinal plants for OC prevention and the recent developments in bioactive synthetic analogs towards OC management...
August 19, 2022: Frontiers in Bioscience (Scholar Edition)