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Frontiers in Bioscience (Elite Edition)

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https://www.readbyqxmd.com/read/28410155/the-puzzle-of-bakanae-disease-through-interactions-between-fusarium-fujikuroi-and-rice
#1
REVIEW
Slavica Matic, Maria L Gullino, Davide Spadaro
Bakanae disease, one of the most noteworthy seedborne rice diseases, is caused by Fusarium fujikuroi, a member of the Gibberella fujikuroi species complex. The decreasing availability of chemical seed-dressing products over the last few years has raised the concerns of rice seed companies regarding bakanae disease. Therefore, new research trends require a deeper investigation into the main aspects of bakanae disease through interactions between rice and F. fujikuroi, in order to find new resistant or tolerant cultivars and alternative bakanae disease control strategies, as well as to develop more sensitive molecular diagnostic techniques...
June 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28410154/current-status-of-a-unique-vaccine-preventing-pregnancy
#2
Gursaran P Talwar, Kripa N Nand, Jagdish C Gupta, Atmaram H Bandivdekar, Radhey S Sharma, Nirmal Kumar Lohiya
The ability of a vaccine linking beta hCG to a carrier to generate antibodies against hCG, its reversibility and safety was established by Phase I clinical trials conducted in India, Finland, Sweden, Chile and Brazil. Employing a hetero-species dimer (beta hCG-╬▒oLH) linked to tetanus toxoid further improved the immunogenicity of the vaccine. Phase II clinical trials showed that anti-hCG titres above 50 ng/ml prevented pregnancy of sexually active fertile women without derangement of ovulation and menstrual regularity...
June 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28410153/the-cognitive-dysregulation-of-internet-addiction-and-its-neurobiological-correlates
#3
REVIEW
Yeon Jin Kim, Dai Jin Kim, Jung-Seok Choi
Individuals with Internet addiction (IA) show loss of control and recurring maladaptive Internet use. This condition has negative consequences and causes significant psychosocial distress. Here, we review neurobiological changes in four key paradigms in cognitive domain in IA including reward processing, impulsivity, cue reactivity, and decision-making. IA is associated with alterations in prefrontal-cingulate region activation during the inhibition of inappropriate responses. Such patterns are also observed in cue-reactivity paradigm tasks, suggesting a relationship with loss of control and deficits in the control of cue-eliciting behavior...
June 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28410152/fungal-immunomodulatory-proteins-in-the-context-of-biomedicine
#4
REVIEW
Paula Tatiana Uribe-Echeverry, German Ariel Lopez-Gartner
Fungi represent a large group of biodiverse microorganisms with potential applications ranging from industrial fields to the treatment for human diseases. A large number of pharmacologically active compounds including terpenoids, polysaccharides and proteins have been derived from these microorganisms. Fungal Immunomodulatory Proteins (FIPs) are a group of active compounds that are being considered for the treatment of asthma, allergy, autoimmune diseases and cancer. Here, we discuss the discovery, heterologous production bioactive mechanisms of action and their potential use in biomedicine...
June 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28410151/effect-of-ancestry-on-interleukin-10-haplotypes-in-chronic-periodontitis
#5
Camile de Barros Lopes, Regina Fatima Feio Barroso, Rommel Mario Rodrigues Burbano, Patricia Aleixo Garcia, Pablo Diego do Carmo Pinto, Ney Pereira Carneiro Dos Santos, Sidney Emanuel Batista Santos, Andrea Kely Campos Ribeiro-Dos-Santos
Chronic periodontitis is caused by an inflammatory reaction of the periodontal tissues and alveolar bone. This inflammation is caused by periodontopathic bacteria located in the subgingival biofilm, resulting in inflammatory reactions that may lead to loss of attachment. This tissue destruction is a consequence of host immune and inflammatory responses to specific periodontal pathogens and their metabolic products. Cytokines modulate the immune response, altering its efficiency in the competition against pathogens and increasing periodontal susceptibility...
June 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28199190/filamentous-hemagglutinin-adhesin-fhab-limits-a-baumannii-biofilm-formation
#6
Shakiba Darwish Alipour Astaneh, Iraj Rasooli, Seyed Latif Mousavi Gargari
Increased resistance and survival, as well as immune evasion, play a significant role in the pathogenicity of Acinetobacter baumannii. Here, we report on the adhesion of the bacterium to epithelial cells and formation of biofilm on abiotic surfaces. We identificed autotransporter (AT) genes that encode homologues (Fha-like) of the two-partner secretion system (TPS) in A.baumannii (ATCC19606) which we designate as FhaB (exoprotein) and FhaC (transporter) and demonstrate that these novel genes, are under the control of distinct regulatable promoters within either the same (FhaBC) or two distinct (FhaB and FhaC) cells...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28199189/presence-of-psa-antibodies-in-seminal-plasma-of-infertile-men
#7
Vanessa A Cuppett, Suresh C Sikka, Rajesh K Naz
Immunoinfertility due to antisperm antibodies and semen hyperviscosity are among major causes of male infertility. Although the modulation of prostate-specific antigen (PSA) has been investigated in prostate abnormalities, its role and the effect of its dysfunction in male fertility/infertility have not been extensively examined. The present study was conducted to examine the presence of PSA antibodies locally in the seminal plasma of men having immunoinfertility and semen hyperviscosity. Seminal plasma samples from immunoinfertile men (n=25), men with hyperviscous semen (n=25), and normal men (n=24) were collected and analyzed for immunoreactivity with PSA in ELISA and Western blot...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28199188/trigonella-seed-extract-ameliorates-inflammation-via-regulation-of-the-inflammasome-adaptor-protein-asc
#8
Nidhi Sharma, Samyuktha Suresh, Ananya Debnath, Sushmita Jha
Trigonella foenum-graecum (fenugreek) is an important medicinal plant, well known for its anti-inflammatory properties. However, the underlying cellular and molecular mechanisms of its action remain largely unknown. The apoptosis associated speck like protein containing a caspase recruitment domain (CARD) (ASC) is central to inflammatory and cell death pathways in innate and adaptive immunity. Here, we show that fenugreek seed extract provides cytoprotection to bacterial lipopolysaccharide (LPS) inflammed and nanosilica-treated fibroblasts via a reactive oxygen species independent pathway...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28199187/combinatorial-effect-of-curcumin-with-docetaxel-modulates-apoptotic-and-cell-survival-molecules-in-prostate-cancer
#9
Saswati Banerjee, Santosh K Singh, Indrajit Chowdhury, James W Lillard, Rajesh Singh
Docetaxel is the most commonly used chemotherapeutic agent to target androgen signaling in metastatic prostate cancer (PCa); however, prolonged treatment with docetaxel results in drug-resistant cancer cells. Combination therapies have the potential of increasing the effectiveness of drug treatment as well as decreasing the side effects. Curcumin is a nontoxic organic compound with multifaceted chemopreventive potential. In this study, we evaluated whether curcumin can reinforce the effect of docetaxel on PCa cells...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28199186/potential-of-redox-therapies-in-neurodegenerative-disorders
#10
Elzbieta Miller, Lukasz Markiewicz, Jacek Kabzinski, Dominik Odrobina, Ireneusz Majsterek
Recently significant advances have been made to understand the pathophysiological mechanisms of neurodegenerative disorders to provide real therapeutic benefits. There is evidence that persistent inflammation and oxidative stress are the crucial factors of ongoing cell damage in neurodegenerative complex etiology. The variety of reactive oxygen and nitrogen species are the cause of both axonal and neuronal destruction, which is pathological hallmark of neurodegeneration. Therefore, the reduction of oxidative stress is currently one of the main neuroprotective strategies...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28199185/age-and-sex-related-differences-in-normal-pituitary-gland-and-fossa-volumes
#11
Hrvoje Ivan Pecina, Tatjana Cicvara Pecina, Vlasta Vyroubal, Ivan Kruljac, Mario Slaus
This study investigates the influence of age and sex on the volumes of the pituitary fossa and gland in 91 males and 108 females from Croatia who underwent magnetic resonance imaging of the endocranium for complaints not related to the pituitary gland. Isometric 3DT1 MPRAGE and 3DT1 MPR sequences were obtained on 1.5. Tesla and analysed on ISSA software. The volumes were obtained from the sum of all the areas multiplied by the thickness of the section. The mean volume of the pituitary fossa for males was 1111...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28199184/biphasic-organo-bioceramic-fibrous-composite-as-a-biomimetic-extracellular-matrix-for-bone-tissue-regeneration
#12
Sanjay Kumar, James A Stokes Iii, Derrick Dean, Christian Rogers, Elijah Nyairo, Vinoy Thomas, Manoj K Mishra
In bone tissue engineering, the organo-ceramic composite, electrospun polycaprolactone/hydroxyapatite (PCL/HA) scaffold has the potential to support cell proliferation, migration, differentiation, and homeostasis. Here, we report the effect of PCL/HA scaffold in tissue regeneration using human mesenchymal stem cells (hMSCs). We characterized the scaffold by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscope (SEM) and assessed its biocompatibility...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27814598/associations-of-alzheimer-s-disease-with-macular-degeneration
#13
Leonardo Biscetti, Elisa Luchetti, Andrea Vergaro, Paola Menduno, Carlo Cagini, Lucilla Parnetti
There is growing evidence of epidemiological, genetic, molecular and clinical links between Alzheimer's disease (AD) and age-related macular degeneration (AMD). Major interest in the relationship between AD and AMD has derived from the evidence that beta-amyloid, the main component of senile plaques, the hallmark of AD, is also an important component of drusen, the hallmark of AMD. This finding has a great potential in the present era of anti-amyloid agents for the treatment of AD. The connection between AD and AMD is also supported by the evidence that the two diseases share other pathophysiological factors, such as oxidative stress and neuroinflammation...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27814597/three-dimensional-tumor-models-for-cancer-studies
#14
Patrice Penfornis, Krishna C Vallabhaneni, Amol V Janorkar, Radhika R Pochampally
It is well recognized that one of the major drawbacks of using traditional two dimensional cultures to model the living systems is inaccurately reflecting the physiological manner in which modulators, nutrients, oxygen, and metabolites are applied and removed. Moreover, the two dimensional culture system poorly reflects how different cell types interact with each other in the same microenvironment. Since the first global development of three dimensional (3D) cell culture techniques in the late 1960s, this last decade has seen an explosion of studies to promote 3D models in the fields of regenerative medicine and cancer...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27814596/diagnosis-of-cardiac-allograft-vasculopathy-challenges-and-opportunities
#15
Bhavesh Patel, Aashish Ahuja, Ghassan S Kassab, Carlos A Labarrere
Cardiac allograft vasculopathy (CAV) is one of the most common long-term complications in patients following heart transplantation. Because of its irreversible nature, early detection is essential to impact progression. Thus, imaging techniques play a crucial role in the diagnosis and subsequent treatment. Major advancements in imaging and analysis are required to overcome the limitations of current techniques. Coronary angiography which is the standard method, presents low sensitivity in detection, especially at an early stage...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27814595/particulate-beta-glucan-induces-early-and-late-phagosomal-maturation-in-murine-macrophages
#16
Nida Fatima, Tarun Upadhyay, Deepak Sharma, Rolee Sharma
Beta-glucans are carbohydrates (glucose polymers) found in the cell walls of fungi, yeast, algae, lichens, and plants such as oats and barley. Beta-glucans bind to glucan receptor on phagocytic cells and modify these cells to become "immunologically active" by generating a variety of innate immune responses. Particulate beta-glucan has been specifically shown to engage dectin-1 receptor, which leads to the recruitment and activation of nicotinamide adenine dinucleotide phosphate oxidase-2 (NOX-2) and release of antimicrobial reactive oxygen species (ROS)...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27814594/cardiac-allograft-vasculopathy-microvascular-arteriolar-capillaries-capioles-and-survival
#17
Carlos A Labarrere, Beate R Jaeger, Ghassan S Kassab
Cardiac allograft vasculopathy (CAV) is a serious complication of heart transplantation in adults and children. Risk factors include human leukocyte antigen mismatches, number and duration of rejection episodes, type of immunosuppression, antibody-mediated rejection, hypertension, hyperlipidemia, obesity, smoking, diabetes, cytomegalovirus infection, mode of donor brain death, donor age and ischemia/reperfusion injury. Endothelial injury and dysfunction in CAV are characterized by changes in adhesion molecules and up-regulation of major histocompatibility class II antigens followed by endothelial activation of complement C4d...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27814593/design-synthesis-and-use-of-peptoids-in-the-diagnosis-and-treatment-of-cancer
#18
Arijit Bhowmik, Malini Basu, Mrinal K Ghosh
Genetic variations in cancer cells are the underpinning for the development of resistance and failure of the treatment by current anticancer drugs. Thus, an ideal drug must overcome failure of treatment and prevents development of drug resistance. There are a wide variety of emerging, easy to prepare and cost effective group of drugs that are collectively called peptoids or peptidomimetics. These new set of drugs exhibit distinct features including protease resistance, are non-immunogenic, do not hinder functionality and backbone polarity, and can adopt different conformations...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27814592/ros-mediated-pro-apoptotic-effects-of-tinospora-cordifolia-on-breast-cancer-cells
#19
Jamal Akhtar Ansari, Namrata Rastogi, Mohammad Kaleem Ahmad, Abbas Ali Mahdi, Abdul Rahman Khan, Ravi Thakur, Vikas Kumar Srivastava, Durga Prasad Mishra, Nishat Fatima, Homa Jilani Khan, Mohammad Waseem
The inevitable development of chemoresistance and unmanageable side effects are the major therapeutic challenges in management of breast cancer imposing an urgent need for identification of novel therapeutic agents. In the present investigation, we report anti-proliferative activity of chloroform fraction of Tinospora cordifolia (TcCF), an Ayurvedic medicinal plant, on breast cancer cells. We found that TcCF inhibited growth of breast cancer cells, MDA-MB-231 and MCF-7. More interestingly, we observed TcCF treatment increased intra-cellular ROS levels, altered expression of pro and anti-apoptotic genes, decreased colony formation ability and induced apoptosis in breast cancer cells...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27814591/insight-into-role-of-microbiota-gut-brain-peptides-as-a-target-for-biotechnology-innovations
#20
Carina Elisei, Alinne Pereira de Castro
It has long been understood that some microorganisms may modify their hosts behavior in various systems. Nevertheless, it has only been in recent years that gut microbiota have opened new perspectives to appreciate their potential for affect complex neurological function in mammals. Efforts have demonstrated the ability of these gut-microbiota to impact neurological outcomes, suggested a prominent role for the gut microbiota in the gut-brain interactions, indicating that alterations in bidirectional microbiota-brain-gut may be involved in a number of brain disorders...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
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