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Materials Science & Engineering. C, Materials for Biological Applications

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https://www.readbyqxmd.com/read/30274138/photoactivated-water-disinfecting-and-biological-properties-of-ag-nps-sm-doped-zno-nanorods-cuttlefish-bone-composite-in-vitro-bactericidal-cercaricidal-and-schistosomicidal-studies
#1
Atef S Darwish, Fatma E A Bayaumy, Hanan M Ismail
Herein, eco-friendly composite was synthesized by embedding silver (Ag) nanospheres onto aragonitic cuttlefish bone (CB)-stabilized samarium doped zinc oxide (Sm-doped ZnO) nanorods. The operating interaction profile and the photoactive behavior of this nanocomposite were assessed via XRD, FTIR, Raman, TEM, FE-SEM, DLS, DRS and PL techniques. Locality of Sm-doped ZnO and its attaching modes to the cuttlefish bone lamella were highly dominated by embedding Ag NPs that encouraged Zn2+ Lewis acid sites to electrostatically interact with aragonite carbonates in the channeled porous CB system...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274137/in-vitro-and-in-vivo-cytotoxicity-evaluation-of-cast-functionally-graded-biomaterials-for-dental-implantology
#2
Shimaa El-Hadad, Engie M Safwat, Nehal F Sharaf
An innovative technique of casting the titanium implant alloys and its calcium phosphate coating using centrifugal casting method was proposed in the current study. This one-step, self-coating technique results in formation of functionally graded biomaterials (FGBMs) of calcium phosphate/Titanium alloys. Two groups of samples (Group 1 and Group 2) were prepared utilizing self-coated titanium‑niobium (Ti-6Al-7Nb) and titanium- vanadium (Ti-6Al-4V) alloys respectively. The cast samples were then prepared for in-vitro cytocompatibility evaluation, in-vivo systemic toxicity and osseointegration evaluation...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274136/development-of-three-dimensional-printing-polymer-ceramic-scaffolds-with-enhanced-compressive-properties-and-tuneable-resorption
#3
Zuoxin Zhou, Eoin Cunningham, Alex Lennon, Helen O McCarthy, Fraser Buchanan, Nicholas Dunne
In this study, bone tissue engineered scaffolds fabricated via powder-based 3D printing from hydroxyapatite (HA) and calcium sulphate (CaSO4 ) powders were investigated. The combination of using a fast resorbing CaSO4 based powder and the relatively slower HA powder represents a promising prospect for tuning the bioresorption of 3D printed (3DP) scaffolds. These properties could then be tailored to coincide with tissue growth rate for different surgical procedures. The manufactured scaffolds were infiltrated with poly(ε‑caprolactone) (PCL)...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274135/aminopeptidase-n-cd13-targeted-mr-and-nirf-dual-modal-imaging-of-ovarian-tumor-xenograft
#4
Ying Meng, Zixin Zhang, Kang Liu, Ling Ye, Yuting Liang, Wei Gu
The development of tumor-specific imaging nanoprobes with the potential to improve the accuracy of cancer diagnosis has become an area of intense research. Aminopeptidase N (CD13) predominantly expresses on the surface of ovarian tumor cells and can be specifically recognized by Asn-Gly-Arg (NGR) peptide. The applicability of CD13 as a target for specific ovarian tumor imaging, however, remains unexploited so far. In this study, Cy5.5-labeled, NGR-conjugated iron oxide nanoparticles (Cy5.5-NGR-Fe3 O4 NPs) were prepared as an ovarian tumor specific bimodal imaging nanoprobe...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274134/facile-incorporation-of-redv-into-porous-silk-fibroin-scaffolds-for-enhancing-vascularization-of-thick-tissues
#5
Danyu Yao, Zhiyong Qian, Jin Zhou, Ge Peng, Gang Zhou, Haifeng Liu, Yubo Fan
Rapid neovascularization within scaffolds is critical for the regeneration of thick complex tissues. The surface immobilization of peptides and other active molecules have been explored to improve the vascularization capacity of implants. However, the rapid degradation of these molecules, the reaction conditions and cross-linking usually result in decreased vascularization capability. Here, we introduced a temperate, all-aqueous process to achieve bulk porous silk fibroin (SF) scaffolds. A temperature controlled process was used to induce the water stable structure by SF self-assembly...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274133/high-toxicity-of-bi-oh-3-and-%C3%AE-bi-2-o-3-nanoparticles-towards-malignant-9l-and-mcf-7-cells
#6
K Bogusz, M Tehei, D Cardillo, M Lerch, A Rosenfeld, S X Dou, H K Liu, K Konstantinov
Here we report the extreme toxicity in vitro of Bi(OH)3 and α-Bi2 O3 nanoparticles (NPs), obtained through a facile synthesis with an average single particle size of 6-10 nm, tested on malignant gliosarcoma 9L and MCF-7 human breast cancer cells. For both nanomaterials, clonogenic assays reveal a mortality of over 90% in 9L and MCF-7 cells for a concentration of 50 μg/mL after incubation for 24 h. Moreover, the NPs show a significant mortality of up to 60% in the malignant cells at the very low concentration of 6...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274132/multifunctional-polymer-coatings-for-titanium-implants
#7
Barbara Szaraniec, Kinga Pielichowska, Ewelina Pac, Elżbieta Menaszek
The aim of this work was to modify the surface of the titanium implants by application of multifunctional polymer coatings based on polyurethane and its composites with graphene and β-TCP. Graphene was used as an antibacterial agent, TCP as a bioactive component, and polymer coating as a corrosion protection of metal. As a result, materials with different surface characteristic, from hydrophilic to hydrophobic, varying in bioactivity and biocompatibility, were obtained. Wettability of the materials was tested by the sessile drop method; surface roughness was assessed on the basis of Ra parameter, measured by contact profilometry...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274131/effect-of-heat-transfer-capability-on-micropore-structure-of-freeze-drying-alginate-scaffold
#8
Conger Wang, Wei Jiang, Wenqian Zuo, Guangting Han, Yuanming Zhang
Biodegradable porous scaffold is widely used in the field of tissue engineering. Scaffolds were required to have proper microstructure with suitable size, gradient, shape and porosity to mimic the specific three-dimensional structure of extracellular matrix. Taken the simple technique of freeze-drying, the nucleation and growth of ice crystals were affected by thermal behavior of solution during freezing process, which could be controlled to tailor and predict the pore structure in scaffold. This paper aimed to reveal the effect of containers' heat-transfer capability on the thermal behaviors of solution, and then its influence to pore structure in scaffold...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274130/antibacterial-dental-adhesive-resins-containing-nitrogen-doped-titanium-dioxide-nanoparticles
#9
Fernando Luis Esteban Florez, Rochelle Denise Hiers, Preston Larson, Matthew Johnson, Edgar O'Rear, Adam J Rondinone, Sharukh Soli Khajotia
The development of dental adhesive resins with long-lasting antibacterial properties is a possible solution to overcome the problem of secondary caries in modern adhesive dentistry. OBJECTIVES: (i) Synthesis and characterization of nitrogen-doped titanium dioxide nanoparticles (N_TiO2 ), (ii) topographical, compositional and wettability characterization of thin-films (unaltered and experimental) and, (iii) antibacterial efficacy of N_TiO2 -containing dental adhesives against Streptococcus mutans biofilms...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274129/triclosan-loaded-polyurethane-micelles-with-ph-and-lipase-sensitive-properties-for-antibacterial-applications-and-treatment-of-biofilms
#10
Yuling Su, Lili Zhao, Fancui Meng, Zhuangzhuang Qiao, Yan Yao, Jianbin Luo
Three different kinds of polyurethane (PU) micelles, i.e. PEG-c-PU, PEG-g-PU and PEG-b-PU, with hydrophobic PCL core and hydrophilic PEG corona were prepared by self-assembly method. DLS studies illustrated that PEG-g-PU micelles showed pH dependent surface charge switching properties while no obvious surface charge switching activities were found for PEG-b-PU and PEG-c-PU micelles. Triclosan was loaded into PCL core by dialysis method with pretty high encapsulate content and efficiency and the payloads were released at an accelerate rate in the presence of lipase...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274128/corrosion-behaviour-and-cell-interaction-of-ti-6al-4v-alloy-prepared-by-two-techniques-of-3d-printing
#11
Jaroslav Fojt, Michaela Fousova, Eva Jablonska, Ludek Joska, Vojtech Hybasek, Eva Pruchova, Dalibor Vojtech, Tomas Ruml
3D printing seems to be the technology of the future for the preparation of metallic implants. For such applications, corrosion behaviour is pivotal. However, little is published on this topic and with inconsistent results. Therefore, we carried out a complex study in which we compared two techniques of the 3D printing technology - selective laser melting and electron beam melting. The corrosion behaviour was studied in physiological solution by standard electrochemical techniques and susceptibility to localised corrosion was estimated too...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274127/a-water-soluble-silver-i-formulation-as-an-effective-disinfectant-of-contact-lenses-cases
#12
M P Chrysouli, C N Banti, Ι Milionis, D Koumasi, C P Raptopoulou, V Psycharis, I Sainis, S K Hadjikakou
The antibacterial effect of the already known water-soluble compound {[Ag6 (μ3 -Hmna)4 (μ3 -mna)2 ]2- ·[(Et3 NH)+ ]2 ·(DMSO)2 ·(H2 O)} (AGMNA) (H2 mna = 2‑mercapto‑nicotinic acid) was evaluated by the mean of the Minimum Inhibitory Concentration (MIC), the Minimum Bactericidal Concentration (MBC) and the Inhibitory Zone (IZ), against the bacterial strains Pseudomonas aeruginosa (PAO1) and Staphylococcus aureus (St. aureus) which settle in the cornea, in bacterial keratitis. The MICs' of AGMNA against PAO1 and St...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274126/3d-culture-of-neural-stem-cells-within-conductive-pedot-layer-assembled-chitosan-gelatin-scaffolds-for-neural-tissue-engineering
#13
Shuping Wang, Shui Guan, Wenfang Li, Dan Ge, Jianqiang Xu, Changkai Sun, Tianqing Liu, Xuehu Ma
Neural stem cells (NSCs), as a self-renewing and multipotent cell population, have been widely studied for never regeneration. Engineering scaffold is one of the important factors to regulate NSCs proliferation and differentiation towards the formation of the desired cells and tissues. Because neural cells are electro-active ones, a conductive scaffold is required to provide three-dimensional cell growth microenvironments and appropriate synergistic cell guidance cues. In this study, a poly (3,4‑ethylenedioxythiophene)/chitosan/gelatin (PEDOT/Cs/Gel) scaffold was prepared via in situ interfacial polymerization, with a nanostructured layer of PEDOT assembling on the channel surface of porous Cs/Gel scaffold...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274125/a-novel-gold-based-stimuli-responsive-theranostic-nanomedicine-for-chemo-photothermal-therapy-of-solid-tumors
#14
Farideh Mahmoodzadeh, Mojtaba Abbasian, Mehdi Jaymand, Roya Salehi, Elnaz Bagherzadeh-Khajehmarjan
The chemo-photothermal therapy performance of a novel theranostic nanoparticles that fabricated through the conjugation of HS-poly(ε-caprolactone)-block-poly(N-isopropylacrylamide)-block-poly(acrylic acid) (HS-PCL-b-PNIPAAm-b-PAA) and gold nanoparticles (GNPs) was extensively investigated. The GNPs@polymer conjugate theranostic NPs was loaded with doxorubicin hydrochloride (DOX) as an anticancer drug through electrostatic interactions to afford GNPs@polymer-DOX theranostic nanomedicine. Temperature and pH-triggered in vitro drug release behavior of the developed theranostic nanomedicine were also examined...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274124/tuneable-hydrogels-of-caf1-protein-fibers
#15
Gema Dura, Helen Waller, Piergiorgio Gentile, Jeremy H Lakey, David A Fulton
Capsular antigen fraction 1 (Caf1) is a robust polymeric protein forming a protective layer around the bacterium Yersinia pestis. Occurring as ≈1 μm polymeric fibers, it shares its immunoglobulin-like fold with the majority of mammalian extracellular proteins such as fibronectin and this structural similarity suggests that this unusual polymer could form useful mimics of the extracellular matrix. Driven by the pressing need for reliable animal-free 3D cell culture environments, we showed previously that recombinant Caf1 produced in Escherichia coli can be engineered to include bioactive peptides, which influence cell behavior...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274123/-the-return-of-ceramic-implants-rose-stem-inspired-dual-layered-modification-of-ceramic-scaffolds-with-improved-mechanical-and-anti-infective-properties
#16
Chen Li, Fanrong Ai, Xinxin Miao, Hang Liao, Fengshun Li, Mingzhuo Liu, Fen Yu, Lina Dong, Ting Li, Xiaolei Wang
Nowadays, traditional ceramics for bone implants have considerably replaced by metal based biomedical materials, attributing to the friability of ceramics. However, ceramic implants possess excellent biocompatibility and longtime abrasion resistance. They should be more desirable for long-term uses of implants in case their fragility had been overcome. In the present work, inspired from natural rose, a dual-layer-modified ceramic scaffold was constructed by coating a superplastic layer of isocyanate (ISO) resin and a nano Zinc Oxide (nano-ZnO) layer on the ceramic scaffold...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274122/novel-core-shell-dextran-hybrid-nanosystem-for-anti-viral-drug-delivery
#17
K S Joshy, Anne George, S Snigdha, Blessy Joseph, Nandakumar Kalarikkal, Laly A Pothen, Sabu Thomas
Zidovudine (AZT) is an antiviral drug extensively used for combating the global pandemic- HIV/AIDS. However, its uses are overshadowed by its short half -life, poor aqueous solubility and inability to cross physiological barriers. This study highlights a nanosystem consisting of dextran and stearic acid for AZT delivery. This hybrid nanoparticle was prepared by double emulsion solvent evaporation method. The morphological analysis of the prepared nanoparticles was carried out by transmission electron microscopy (TEM) and structural analysis through FTIR spectroscopy...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274121/effects-of-graphene-on-the-structure-properties-electro-response-behaviors-of-go-paa-composite-hydrogels-and-influence-of-electro-mechanical-coupling-on-bmsc-differentiation
#18
Kun Qiao, Shaolin Guo, Yudong Zheng, Xuetao Xu, Haoye Meng, Jiang Peng, Ziyuan Fang, Yajie Xie
Electro-responsive Graphene oxide-poly(acrylic acid) (GO-PAA) nanocomposite hydrogels with different concentrations of GO were successfully fabricated via in situ polymerization. The covalently crosslinked PAA network is intertwined with GO sheets by the bridging of hydrogen-bond interactions thus resulting in an integrated and stable hydrogel network. The swelling, mechanical and conductivity properties of the hydrogel are impacted as a result. The influences of different factors on the electro-response behavior of the hydrogels were deeply explored...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274120/effects-of-gallic-acid-biofabricated-rgo-nanosheets-combined-with-radiofrequency-radiation-for-the-treatment-of-renal-cell-carcinoma
#19
Zhengyao Jiang, Hailong Jin, Shu Sun, Changqing Chen, Jie Zhang, Zefeng Guo, Xiaoyou Liu
The combination of biologically active compounds and nanomaterials in biomedicine field is growing rapidly and provided excellent forecasts for the progress of facile non-invasive approaches for the diagnosis of cancer therapy. In this present study, we demonstrated that as-prepared gallic acid (GA) coated reduced graphene oxide (rGO) combined with radiofrequency (RF) ablation has facilitated for the treatment of human renal epithelial cancer (A-489) cells without disturbing the renal proximal epithelial (HK-2) cells...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30274119/one-step-fabrication-and-characterization-of-fe-3-o-4-hbpe-ddsa-inh-nanoparticles-with-controlled-drug-release-for-treatment-of-tuberculosis
#20
Tingting Lu, Yan Wu, Chili Zhao, Fu Su, Jine Liu, Zhenye Ma, Qiaorong Han
In this study, Fe3 O4 /hyperbranched polyester-(2-dodecen-1-yl)succinic anhydride2-Dodecen-1-/isoniazid magnetic nanoparticles (Fe3 O4 /HBPE-DDSA/INH MNPs) with controlled drug release characteristics were synthesized successfully by a simple one-step method. Orthogonal experiments were performed to optimize the loading capacity and encapsulation efficiency of the MNPs. The structure of the Fe3 O4 /HBPE-DDSA/INH MNPs was characterized by 1 H nuclear magnetic resonance spectroscopy, matrix-assisted laser desorption/ionization mass spectrometry, Fourier transform infrared spectroscopy, X-ray diffraction analysis, transmission electron microscopy, and superconducting quantum interference device measurements, while their properties were characterized based on swelling behavior observations, in-vitro release experiments, and cytotoxicity analysis...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
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