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Materials Science & Engineering. C, Materials for Biological Applications

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https://www.readbyqxmd.com/read/29752124/fabrication-of-hyaluronidase-responsive-biocompatible-multilayers-on-bmp2-loaded-titanium-nanotube-for-the-bacterial-infection-prevention
#1
Linawati Sutrisno, Yan Hu, Xinkun Shen, Menghuan Li, Zhong Luo, Liangliang Dai, Sixiang Wang, Julia Li Zhong, Kaiyong Cai
Infection associated with orthopedic implants is the chief cause of implant failure. An important consideration to prevent the infection at implants is to inhibit the biofilm formation for the initial 6 h. Therefore, we fabricated hyaluronidase-sensitive multilayers of chitosan (Chi)/sodium hyaluronate-lauric acid (SL) onto the surface of bone morphogenetic protein 2 (BMP2) loaded titanium nanotube (TNT) via spin-assisted layer-by-layer technique. The results of both Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (1 H NMR) confirmed the successful synthesis of SL...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752123/synthesis-and-characterization-of-kaempferol-based-ruthenium-ii-complex-a-facile-approach-for-superior-anticancer-application
#2
Prakash Thangavel, Buddolla Viswanath, Sanghyo Kim
In this study, we synthesized a novel metal flavonoid complex and investigated its effects on the non-small cell lung cancer cell lines, A549 and toxicity on the human dermal fibroblast cell lines, HDFa. 1 H, 13 C NMR, single crystal X-ray diffraction and elemental micro analysis (C,H,N,S/O) were used to characterize the synthesized kaempferol-based Ru (II) complex. Cell toxicity was studied using MTT assay and electric cell substrate impedance sensing (ECIS). It was evident from the MTT results that no significant cytotoxicity in HDFa cells occurs with the synthesized complex, but in case of A549 cells, significant cytotoxicity was observed even at low concentrations (10-20 μm)...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752122/strontium-modified-chitosan-montmorillonite-composites-as-bone-tissue-engineering-scaffold
#3
Aysel Koç Demir, Ayşe Eser Elçin, Yaşar Murat Elçin
The objective of this study is to develop chitosan/montmorillonite (C/MMT) composite scaffolds based on improved properties for bone tissue engineering applications. With the freeze-drying technique, strontium (Sr2+ ) modified C/MMT composite scaffold with an interconnected porous structure was produced. X-ray diffraction, fourier transform infrared spectroscopy, thermal gravimetric analysis, and scanning electron microscopy (SEM) were employed to investigate the structural properties, surface morphology and porosity of the composite scaffold...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752121/self-assembled-nanomicelles-of-amphiphilic-clotrimazole-glycyl-glycine-analogue-augmented-drug-delivery-apoptosis-and-restrained-melanoma-tumour-progression
#4
Amanpreet Kaur, Kiran Jyoti, Ashish Baldi, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan
In present investigation, self-assembled nanomicelles of amphiphilic clotrimazole glycyl-glycine (CLT-GG-SANMs) analogue were customized for augmenting drug delivery, permeability and apoptosis in B16F1 mouse melanoma cancer cells both in vitro and in vivo following intratumoral (i.t.) route of administration. The mean particle size of CLT-GG-SANMs was measured to be 35.9 ± 3.4 nm in addition to zeta-potential of -17.1 ± 3.5 mV. The shape of CLT-GG-SANMs was visualized to be smooth and spherical as like nanoparticles...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752120/effects-of-printing-induced-interfaces-on-localized-strain-within-3d-printed-hydrogel-structures
#5
Kyle Christensen, Brian Davis, Yifei Jin, Yong Huang
Additive manufacturing, or 3D printing, is a promising approach for the fabrication of biological structures for regenerative medicine applications using tissue-like materials such as hydrogels. Herein, inkjet printing is implemented as a model droplet-based 3D printing technology for which interfaces have been shown to form between printed lines within printed layers of hydrogel structures. Experimental samples with interfaces in two orientations are fabricated by inkjet printing and control samples with and without interfaces are fabricated by extrusion printing and casting, respectively...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752119/titanium-implant-functionalized-with-antimir-138-delivered-cell-sheet-for-enhanced-peri-implant-bone-formation-and-vascularization
#6
Jun Yan, Bei Chang, Xiangxiang Hu, Can Cao, Lingzhou Zhao, Yumei Zhang
Patients with compromised bone conditions still suffer the problem of deficient osseointegration during dental implant treatment. Developing mesenchymal stem cell (MSC) sheet functionalized titanium implant with proper inductive cue to promote osteogenesis and angiogenesis coupling shall be a good solution. In the present study, the antimiR-138 delivered MSC sheet is used to functionalize the Ti implant. The cell sheet can well integrate with the Ti implant to form the MSC sheet-implant complex (MSIC). The antimiR-138 delivered MSIC shows greatly improved osteogenesis and angiogenesis coupling both in vitro and in vivo...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752118/silk-fibroin-based-biomaterials-for-musculoskeletal-tissue-engineering
#7
REVIEW
Dakun Ma, Yansong Wang, Wenjie Dai
Tissue engineering (TE) is an emerging and promising strategy to heal tissue failure by integrating science and technology of materials, cells and growth factors. With the increasing of aging population, restoring musculoskeletal tissue has become the focus of TE. Among various materials tested in TE, silk fibroin (SF) is increasingly being recognized as a promising material. SF, a natural protein polymer with excellent physiochemical characteristics, has established a good reputation in terms of musculoskeletal tissue engineering (MTE)...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752117/antifertility-effectiveness-of-a-novel-copper-containing-intrauterine-device-material-and-its-influence-on-the-endometrial-environment-in-rats
#8
Shifu Hu, Yingying Wang, Dandan Ke, Fang Zhou, Guiping Cheng, Wei Xia, Changhong Zhu
This study was designed to investigate the antifertility effectiveness of a novel copper-containing intrauterine device material containing a composite of micro-copper (Cu), low-density polyethylene (LDPE), and methyl vinyl silicone rubber (MVQ) and its effects on the endometrial environment in rats. The contraceptive effectiveness was examined 12 days after pregnancy. The pathological changes; factors associated with bleeding, pain, and inflammation in the endometrium; and the surface condition of the implants were investigated after insertion for 90 days...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752116/antimicrobial-and-anticancer-activities-of-silver-nanoparticles-synthesized-from-the-root-hair-extract-of-phoenix-dactylifera
#9
Mohammad Oves, Mohammad Aslam, Mohd Ahmar Rauf, Shariq Qayyum, Huda A Qari, Mohd Shahnawaz Khan, Mohammad Zubair Alam, Shams Tabrez, Arivalagan Pugazhendhi, Iqbal M I Ismail
There is a continuous rise in the rate of medicine consumption because of the development of drug resistance by microbial pathogens. In the last one decade, silver nanoparticles (AgNPs) have become a remarkable choice for the development of new drugs due to their excellent broad-spectrum antimicrobial activity. In the current piece of work, we have synthesized AgNPs from the root extract of Phoenix dactylifera to test their antimicrobial and anti-cancer potential. UV-visible spectra showed the surface plasmon resonance peak at 420 nm λmax corresponding to the formation of silver nanoparticles, FTIR spectra further confirmed the involvement of biological moieties in AgNPs synthesis...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752115/core-shell-structure-of-fe-3-o-4-mtx-ldh-au-nps-for-cancer-therapy
#10
Xiu-Fen Zhao, Wei-Yuan Wang, Xiao-Dong Li, Shu-Ping Li, Fu-Gui Song
Nearly monodispersed magnetic Fe3 O4 @MTX-LDH/Au nanoparticles (NPs) containing the anticancer agent of methotrexate (MTX) were prepared via a coprecipitation-electrostatic interaction strategy. Firstly, layered double hydroxide (LDH) materials were deposited over the surface of Fe3 O4 NPs by the coprecipitation method. Secondly, Au NPs were successfully conjugated onto the surface of LDH through electrostatic interaction. Herein, MTX was used both as the agent for surface modification and the anticancer drug for chemotherapy...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752114/highly-monodispersed-gold-nanoparticles-synthesis-and-inhibition-of-herpes-simplex-virus-infections
#11
Asim Halder, Suvadra Das, Durbadal Ojha, Debprasad Chattopadhyay, Arup Mukherjee
This work relates to quasi spherical gold nanoparticles synthesis and successful antiviral efficacy evaluations against Herpes simplex virus (HSV) infections. Ultrasound induced rapid reduction in gallic acid (GA) leads to highly monodispersed gold nanoparticles (GAunps). GAunps plasmonic peak was recorded at 531 nm with TEM size of 7.86 nm. X-ray diffraction and SAED pattern proved fcc crystalline structure. FTIR studies confirmed nanoparticles surface conjugation with gallic acid. The antiviral efficacy of GAunps was studied against HSV infections in Vero cells...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752113/antifouling-polyvinylidene-fluoride-ultrafiltration-membrane-fabricated-from-embedding-polypyrrole-coated-multiwalled-carbon-nanotubes
#12
Vahid Vatanpour, Ali Ghadimi, Atefeh Karimi, Alireza Khataee, Mohammad Ehsan Yekavalangi
Polypyrrole (PPy) coated raw and oxidized multiwalled carbon nanotubes (MWCNTs) nanocomposites were synthesized and used for hydrophilic modification of polyvinylidene fluoride (PVDF) ultrafiltration membranes. The prepared nanocomposites were characterized using XRD, FTIR and SEM techniques. The hydrophilicity of the fabricated membranes was evaluated using water contact angle measurements, where the mixed matrix membranes presented lower contact angle compared with the bare one. The performance results showed that the pure water flux increased from 152...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752112/bioinspired-mimics-self-assembly-of-redox-activated-phosphorylcholine-based-biodegradable-copolymers-for-enhancing-antitumor-efficiency
#13
Mengtan Cai, Zhengzhong Wu, Yi Li, Jun Cao, Yuanwei Chen, Xianglin Luo
With the purpose of reducing side effects in anticancer therapy, the micelles of a novel reduction-activated copolymer with biomimicking phosphorylcholine, poly(ε-caprolactone)-ss-b-poly(2-methacryloyloxyethyl phosphorylcholine) (PCL-ss-PMPC) are developed. The well-suitable nanosize of micelles with good physiological stability (approximately 50 nm, 2.5 μg/mL) can be quickly internalized into cells due to bioinspired phosphorylcholine property and mainly located in endo/lysosomes. The reduction response of micelles is confirmed by size change and accelerated drug release under reducing environment, proved as better anticancer efficacy in comparison to insensitive micelles...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752111/doxorubicin-dna-adduct-entrenched-and-motif-tethered-artificial-virus-encased-in-ph-responsive-polypeptide-complex-for-targeted-cancer-therapy
#14
K C Ajithkumar, K Pramod
Doxorubicin is a broad spectrum anticancer antibiotic that possesses toxic effects such as cardiomyopathy, that even lead to congestive heart failure. Thus, the development of a new bio-inspired system is required, that retain the advantageous effect of doxorubicin while retarding the side effects. Hence, a system was developed that we describe 'doxorubicin-DNA adduct entrenched artificial virus encased in polypeptide complex'. The drug-DNA adduct (DDA) was prepared by a formaldehyde mediated reaction. A simple chloroform extraction method for the separation of DDA was developed...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752110/evaluation-of-nano-hydrogel-composite-based-on-gelatin-ha-cs-suffused-with-asiatic-acid-zno-and-cuo-nanoparticles-for-second-degree-burns
#15
Thanusha A V, Amit Kumar Dinda, Veena Koul
In the present work, a hydrogel platform composed of biopolymer gelatin, and glycosaminoglycan's (Hyaluronic acid and Chondroitin sulfate) incorporated with Asiatic acid (a triterpenoid) and nanoparticles (Zinc oxide and Copper oxide) has been designed and developed to find out the efficacy of healing in second degree burn wounds in Wistar rats. The developed hydrogel composite has been characterized by physico-chemical methods such as; SEM, swelling, mechanical strength, degradation and drug release kinetics...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752109/the-effect-of-the-androstane-lung-cancer-inhibitor-content-on-the-cell-selective-toxicity-of-hydroxyapatite-chitosan-plga-nanocomposites
#16
Nenad L Ignjatović, Katarina M Penov-Gaši, Jovana J Ajduković, Vesna V Kojić, Smilja B Marković, Dragan P Uskoković
An androstane (17β-hydroxy-17α-picolyl-androst-5-en-3β-yl-acetate (derivative A)) cancer inhibitor was successfully captured in a carrier made of nano-sized hydroxyapatite (HAp) coated with chitosan-PLGA polymer blends (Ch-PLGA). In our previous studies, we demonstrated that it was convenient to use spherical HAp/Ch-PLGA carriers as vehicles to target the lungs following intravenous administration. In this study, we used emulsification and subsequent freeze-drying to load the spherical HAp/Ch-PLGA carriers with varying contents of the derivative A, in order to examine the selective toxicity towards cancerous/healthy lung cells...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752108/surface-decorated-hydroxyapatite-scaffold-with-on-demand-delivery-of-dexamethasone-and-stromal-cell-derived-factor-1-for-enhanced-osteogenesis
#17
Bingjun Zhang, Hongyu Li, Lei He, Zhiwei Han, Teng Zhou, Wei Zhi, Xiaobo Lu, Xiong Lu, Jie Weng
In the process of bone regeneration, relatively early biological events including inflammatory response, angiogenesis, or stem cell homing, help the accompanying target actions of cell differentiation and calcification. Herein, we proposed a novel cell-guided tissue engineering system based on a surface-functionalized porous hydroxyapatite (HA) scaffolds with the ability to recruit cells and accelerate the differentiation of them along the osteoblastic lineage for optimizing large-sized bone defect repair. Inspired by microstructural properties of natural bone, HA scaffolds similar to the trabecular bone structure were prepared via a sugar sphere leaching technique, in which the inter-pore opening size was controllable...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752107/macroporous-microbeads-containing-apatite-modified-mesoporous-bioactive-glass-nanofibres-for-bone-tissue-engineering-applications
#18
Fu-Yin Hsu, Hsien-Wen Hsu, Yu-Han Chang, Jing-Lun Yu, Lih-Rou Rau, Shiao-Wen Tsai
Mesoporous bioactive glass (MBG) has a greater surface area and pore volume than conventional BG. Hence, MBG is useful as a drug delivery carrier. Previously, MBG has been fabricated as dense or porous blocks. Compared to blocks, microbeads have a greater flexibility to fill different-shaped cavities with close packing. Moreover, fibrous materials have proven to increase cell attachment and differentiation because they mimic the three-dimensional structure of the natural extracellular matrix (ECM). Macroporous materials possess porous structures with interconnecting channels that allow the invasive growth of cells and capillaries...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752106/silk-fibroin-nanohydroxyapatite-hydrogels-for-promoted-bioactivity-and-osteoblastic-proliferation-and-differentiation-of-human-bone-marrow-stromal-cells
#19
Marta Ribeiro, Maria H Fernandes, Marisa M Beppu, Fernando J Monteiro, Maria P Ferraz
Silk fibroin (SF) is a natural, biocompatible, and biodegradable polymer having a great potential for the successful regeneration of damaged bone tissue. In the present work, nanohydroxyapatite (nanoHA) was incorporated into SF polymer to form a bioactive composite hydrogel for applications as bone implants. The degradation and bioactive properties of SF/nanoHA composite hydrogels were evaluated. Additionally, biological investigations of human bone marrow stromal cells (hBMSCs) viability, proliferation and differentiation to the osteoblastic phenotype were conducted...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752105/usnic-acid-loaded-polyaniline-polyurethane-foam-wound-dressing-preparation-and-bactericidal-activity
#20
Marcelo R Dos Santos, Jose J Alcaraz-Espinoza, Mateus M da Costa, Helinando P de Oliveira
The improved bactericidal activity of new composites for wound dressing prototypes represents an important strategy for development of more efficient devices that make use of synergistic interaction between components. The doping level of polyaniline represents a critical parameter for its corresponding biologic activity. In this work, it is explored the doping effect of usnic acid on undoped polyaniline, that introduces important advantages namely, improved bactericidal activity of polyaniline and the anti-biofilm properties of lichen derivative...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
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