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Materials Science & Engineering. C, Materials for Biological Applications

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https://www.readbyqxmd.com/read/30606608/delivery-of-platinum-ii-drugs-with-bulky-ligands-in-trans-geometry-for-overcoming-cisplatin-drug-resistance
#1
Xi Yang, Yingjie Yu, Xing Huang, Qixian Chen, Hui Wu, Ran Wang, Ruogu Qi, Yifeng Miao, Yongming Qiu
Drug resistance induced by increasing intracellular levels of detoxifying agents for conventional platinum(II) drugs such as metallothioneins (MTs) and glutathione (GSH) are the major obstacles for widely used platinum-based chemotherapeutic cancer treatment. Here, we developed trans-geometry platinum (II) drugs with sterically hindered bulky ligands PyPt which is able to hind the GSH attack of platinum drug to overcome cisplatin resistance. Moreover, the PyPt can self-assemble with biodegradable copolymer mPEG-PGA into uniform nanoparticles with PyPt drugs in the polymeric core and PEG as the shell, further protecting PyPt from GSH detoxification to further slow the reaction rate with GSH in vivo...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606607/chitosan-based-polymer-bioglass-composites-for-tissue-engineering-applications
#2
REVIEW
Djurdja Vukajlovic, Julie Parker, Oana Bretcanu, Katarina Novakovic
Composite scaffolds formed from polymers and bioglasses have been widely explored for applications in regenerative medicine as they have suitable organic/inorganic structures and properties similar to human hard tissue. Yet, these materials have only been used for non-load-bearing or low load-bearing purposes as they have limited mechanical strength while research is focused on improving their properties. One method of improving mechanical strength is by covalently bonding the organic and inorganic phases. This has been successfully achieved in Class ll hybrids which have covalent bonding between polymers and bioglasses...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606606/importance-of-crosslinking-strategies-in-designing-smart-biomaterials-for-bone-tissue-engineering-a-systematic-review
#3
REVIEW
Gopal Shankar Krishnakumar, Sowndarya Sampath, Shalini Muthusamy, Mary Arlene John
Biomaterials are of significant importance in biomedical applications as these biological macromolecules have moderately replaced classical tissue grafting techniques owing to its beneficial properties. Despite of its favourable advantages, poor mechanical and degradative properties of biomaterials are of great concern. To this regard, crosslinkers have emerged as a smart and promising tool to augment the biological functionality of biopolymers. Different crosslinkers have been extensively used in past decades to develop bone substitutes, but the implications of toxic response and adverse reactions are truly precarious after implantation...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606605/porous-aerogel-and-core-shell-nanoparticles-for-controlled-drug-delivery-a-review
#4
REVIEW
Tzipatly A Esquivel-Castro, M C Ibarra-Alonso, J Oliva, Antonia Martínez-Luévanos
This review presents the methods and general strategies for the synthesis of porous aerogels and core/shell nanoparticles with efficient and controlled drug delivery. Different mechanisms of drug delivery are also discussed, which are influenced by the porosity, surface area, pH and surface functionalization of the aerogel and core/shell nanoparticles. Various porous inorganic, organic, and hybrid systems were compared. In addition, the main physical and chemical characteristics of these porous nanoparticles which enhance the drug loading on the porous nanoparticles were discussed...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606604/current-state-of-green-reduction-strategies-solution-processed-reduced-graphene-oxide-for-healthcare-biodetection
#5
REVIEW
S Taniselass, M K Md Arshad, Subash C B Gopinath
Reduction of graphene oxide becomes an alternative way to produce a scalable graphene and the resulting nanomaterial namely reduced graphene oxide (rGO) has been utilized in a wide range of potential applications. In this article, the level of green reduction strategies, especially the solution-based reduction methods are overviewed based on recent progression, to get insights towards biomedical applications. The degrees of gaining tips with the solution-based green reduction methods, conditions, complexity and the resulting rGO characteristics have been elucidated comparatively...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606603/carbon-dots-the-next-generation-platform-for-biomedical-applications
#6
REVIEW
Krishanu Ghosal, Ashis Ghosh
Among the wide range of carbon family nanomaterials, carbon dots (CDs) one of the promising candidate which has attracted tremendous attention due to its unique advantages such as facile synthesis procedure, easy surface functionalization, outstanding water solubility, low toxicity and excellent photo-physical properties. Due to these unique advantages, CDs are extensively used in catalysis, electronics, sensing, power as well as in biological sectors. In this review we will discuss recent progress in synthesis, structure and fluorescence properties of CDs with special highlight on its biomedical applications, more precisely we will highlight on CDs, for drug/gene delivery, bioimaging and photothermal and photodynamic therapy applications...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606602/cyclodextrin-based-delivery-systems-for-cancer-treatment
#7
REVIEW
Dongjing Zhang, Pin Lv, Cheng Zhou, Yulin Zhao, Xiali Liao, Bo Yang
Cyclodextrins, one of safe excipients, are able to form host-guest complexes with fitted molecules given the unique nature imparted by their structure in result of a number of pharmaceutical applications. On the other hand, targeted or responsive materials are appealing therapeutic platforms for the development of next-generation precision medications. Meanwhile, cyclodextrin-based polymers or assemblies can condense DNA and RNA in result to be used as genetic therapeutic agents. Armed with a better understanding of various pharmaceutical mechanisms, especially for cancer treatment, researchers have made lots of works about cyclodextrin-based drug delivery systems in materials chemistry and pharmaceutical science...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606601/amine-functionalized-porous-silica-coated-nayf-4-yb-er-upconversion-nanophosphors-for-efficient-delivery-of-doxorubicin-and-curcumin
#8
Kumbam Lingeshwar Reddy, Peeyush Kumar Sharma, Ashutosh Singh, Ajay Kumar, Konathala Ravi Shankar, Yashveer Singh, Neha Garg, Venkata Krishnan
Upconversion nanoparticles (UCNP) with unique multi-photon excitation photo-luminescence properties have been extensively explored as novel contrast agents for low-background biomedical imaging. There is an increasing interest in employing UCNPs as carrier for drug delivery as these offers a unique opportunity to combine therapy and diagnostics in one platform (theranostics). In the present work, we report microwave-assisted synthesis of hexagonal NaYF4 :Yb/Er UCNPs coated with porous silica and functionalized with amine (UCNP@mSiO2 )...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606600/synthesis-of-nano-ha-%C3%AE-tcp-mesoporous-particles-using-a-simple-modification-in-granulation-method
#9
Farzad Kermani, Saeid Kargozar, Zahra Tayarani-Najaran, Abbas Yousefi, Sahar Mollazadeh Beidokhti, Mohammad Hadi Moayed
Granulation method in the mixture of oil, water, and polymer was used to synthesize HA/βTCP porous nano-powders. The effects of different types of polymeric-substrate, drying process, and thermal heat-treatment on the crystallization process of calcium phosphate nano-particles were studied. As-synthesized particles were treated with different chemical surface agents to improve their surface charge, cell growth, and cell adhesion properties. X-ray diffraction (XRD) and Brunauer-Emmett-Teller (BET) analyses were employed to explore the phase composition and specific surface area of synthesized powders, respectively...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606599/lithospermi-radix-extract-containing-bilayer-nanofiber-scaffold-for-promoting-wound-healing-in-a-rat-model
#10
Chun-Hsu Yao, Kuo-Yu Chen, Yueh-Sheng Chen, Shu-Jing Li, Chiung-Hua Huang
This study examined the in vitro characteristics and in vivo wound healing effect of novel Lithospermi radix (LR) extract-containing bilayer scaffolds in a rat model. LR extract, which has been used as a traditional herbal medicine for treating skin wounds, was added to a biocompatible gelatin solution. After glutaraldehyde vapor was used to modify the surface of chitosan scaffolds, various ratios of mammalian gelatin and fish collagen (GF100, GF91 and GF82) were electrospun onto the chitosan scaffolds to manufacture bilayer scaffolds...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606598/injectable-hydrogels-from-enzyme-catalyzed-crosslinking-as-bmscs-laden-scaffold-for-bone-repair-and-regeneration
#11
Yajie Zhang, Hong Chen, Tingting Zhang, Yue Zan, Tianyu Ni, Yi Cao, Jine Wang, Min Liu, Renjun Pei
Bone-marrow-derived mesenchymal stem cells possess great potential for tissue engineering and regenerative medicine. In the work, an injectable BMSCs-laden hydrogel system was formed by enzyme-catalyzed crosslinking of hyaluronic acid-tyramine and chondroitin sulfate-tyramine in the presence of hydrogen peroxide and horseradish peroxidase, which was used as a 3D scaffold to explore the behavior of the mesenchymal stem cells. Afterward, the gelation rate, mechanical properties, as well as the degradation process of the scaffold were well characterized and optimized...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606597/corrosion-mechanism-of-the-as-cast-and-as-extruded-biodegradable-mg-3-0gd-2-7zn-0-4zr-0-1mn-alloys
#12
Zhenzhen Gui, Zhixin Kang, Yuanyuan Li
Electrochemical measurements and immersion tests were adopted to investigate corrosion mechanism of the as-cast and as-extruded Mg-3.0Gd-2.7Zn-0.4Zr-0.1Mn (GZKM-1) alloys. Results of immersion tests indicate that corrosion resistance of the as-extruded GZKM-1 alloy is better. Galvanic corrosion between α-Mg matrix and β-(MgZn)3 Gd compounds is the main corrosion mechanism of the two GZKM-1 alloys. Larger α-Mg peeled off from the as-cast samples, then expanded corrosion reaction along discontinuous β-(MgZn)3 Gd compounds making a pit corrosion phenomenon in macro view...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606596/formation-of-porous-biodegradable-scaffolds-based-on-poly-propylene-carbonate-using-gas-foaming-technology
#13
Iman Manavitehrani, Thi Y L Le, Sean Daly, Yiwei Wang, Peter K Maitz, Aaron Schindeler, Fariba Dehghani
Polyester-based scaffolds have been employed in tissue engineering due to their biocompatibility, biodegradability, microstructure, and affordability. However, the acidic degradation byproducts of most common polyesters have the potential to cause inflammation and/or necrosis. In this study, we introduce a porous scaffold with benign degradation byproducts fabricated by gas-foaming based on poly(propylene carbonate) (PPC) blended with starch and bioglass particles. The pore sizes ranged from 100 to 500 μm...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606595/synthesis-characterization-of-copper-oxide-gold-nanoalloys-and-their-peroxidase-like-activity-towards-colorimetric-detection-of-hydrogen-peroxide-and-glucose
#14
Sindisiwe Mvango, Philani Mashazi
Bimetallic copper oxide-gold nanoalloys (CuO-Au nanoalloys) have been prepared and characterized using various techniques confirming their successful synthesis. The peroxidase-like activity of CuO-Au nanoalloys have been investigated and applied towards the colorimetric detection of glucose. CuO-Au nanoalloys as nanoenzymes exhibited peroxidase-like properties which occurred by generating the reactive oxygen species (ROS) due to the catalytic properties of CuO-Au nanoalloys.The generation of ROS was confirmed using radical and/or reactive oxygen species quenching properties of 1,3‑diphenylisobenzofuran (DPBF)...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606594/stability-of-antibacterial-modification-of-nanofibrous-pa6-dtab-membrane-during-air-filtration
#15
Petr Ryšánek, Pavla Čapková, Jiří Štojdl, Josef Trögl, Oldřich Benada, Martin Kormunda, Zdeňka Kolská, Marcela Munzarová
Stable antimicrobial nanofibrous membrane for air filtration based on polyamide 6 (hereafter PA6) modified by 1-dodecyltrimethylammonium bromide (DTAB) has been prepared by electrospinning using one-step technology, i.e. with modifying antimicrobial agent dissolved in spinning solution. Stability of antibacterial membrane function has been tested by air-blowing test to prove the permanency of chemical composition and antibacterial activity. X-ray diffraction, high-resolution scanning electron microscopy (HRSEM) revealed the effect of modifying agent on structure and morphology of PA6 nanofibres...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606593/rgd-functionalization-of-pla-starch-scaffolds-obtained-by-electrospinning-and-evaluated-in-vitro-for-potential-bone-regeneration
#16
Mariana Gutiérrez-Sánchez, Vladimir A Escobar-Barrios, Amaury Pozos-Guillén, Diana M Escobar-García
The engineering of bone tissues represents an area of opportunity for the development of new polymeric compounds. In this context, the objective of this work is the generation and evaluation in vitro of supports obtained from mixtures of starch with poly (lactic acid) (PLA), treated with arginine-glycine-aspartic acid peptides (RGD). For this, non-woven fibers of PLA with different starch content (0.0, 2.5, 5.0 and 10.0%wt) were obtained using the electrospinning technique. Then the physical absorption of RGD was carried out, with the aim of increasing the cellular adhesion of the polymeric material...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606592/a-label-free-and-highly-sensitive-dna-biosensor-based-on-the-core-shell-structured-ceo-2-nr-ppy-nanocomposite-for-salmonella-detection
#17
Nguyen Thi Nguyet, Le Thi Hai Yen, Vu Y Doan, Nguyen Luong Hoang, Vu Van Thu, Hoang Lan, Tran Trung, Vuong-Hung Pham, Phuong Dinh Tam
A core-shell cerium oxide nanorod@polypyrrole (CeO2 -NR@Ppy) nanocomposite-based electrochemical DNA biosensor was studied for Salmonella detection. The core-shell CeO2 -NR@Ppy nanocomposite was prepared by in situ chemical oxidative polymerization of pyrrole monomer on CeO2 -NRs, which provided a suitable platform for electrochemical DNA biosensor fabrication. The immobilization of ss-DNA sequences onto nanocomposite-coated microelectrode was performed via covalent attachment method. DNA biosensor electrochemical responses were studied by cyclic voltammetry and electrochemical impedance spectroscopy with [Fe (CN)6 ]3-/4- as redox probe...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606591/poly-%C3%AE%C2%B5-caprolactone-microspheres-for-prolonged-release-of-selenium-nanoparticles
#18
Nenad Filipović, Ljiljana Veselinović, Slavica Ražić, Sanja Jeremić, Metka Filipič, Bojana Žegura, Sergej Tomić, Miodrag Čolić, Magdalena Stevanović
Poly (ε-caprolactone) (PCL) microspheres as a carrier for sustained release of antibacterial agent, selenium nanoparticles (SeNPs), were developed. The obtained PCL/SeNPs microspheres were in the range 1-4 μm with the encapsulation efficiency of about 90%. The degradation process and release behavior of SeNPs from PCL microspheres were investigated in five different degradation media: phosphate buffer solution (PBS), a solution of lipase isolated from the porcine pancreas in PBS, 0.1 M hydrochloric acid (HCl), Pseudomonas aeruginosa PAO1 cell-free extract in PBS and implant fluid (exudate) from the subcutaneously implanted sterile polyvinyl sponges which induce a foreign-body inflammatory reaction...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606590/evaluation-of-reagents-used-to-coat-the-hollow-fiber-bioreactor-membrane-of-the-quantum%C3%A2-cell-expansion-system-for-the-culture-of-human-mesenchymal-stem-cells
#19
Nathan D Frank, Mark E Jones, Boah Vang, Claire Coeshott
The addition of a coating reagent to promote cell adherence is necessary to prepare the membrane surface of the Quantum® Cell Expansion System hollow-fiber bioreactor for the culture of mesenchymal stem cells. In this study, the efficacy of 8 potential coating reagents has been compared in terms of the doubling times of their cell populations, cell morphology, characterization via flow cytometry, and capacity for trilineage differentiation. Human fibronectin (FN), pooled human cryoprecipitate (CPPT), and recombinant human vitronectin (VN) were successful as coating reagents, and each product has advantages in different cell culture contexts...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30606589/electrophoretically-deposited-mesoporous-magnesium-silicate-with-ordered-nanopores-as-an-antibiotic-loaded-coating-on-surface-modified-titanium
#20
Ashkan Bigham, Ahmad Saudi, Mohammad Rafienia, Shahram Rahmati, Hassan Bakhtiyari, Fatemeh Salahshouri, Mansoureh Sattary, S A Hassanzadeh-Tabrizi
Infection is quite usual for implants after surgery and a systemic administration of antibiotics causes problems before the eradication of bacteria. Localized drug delivery from implants is an effective way by which the mentioned target can be met. In the current work, ordered mesoporous magnesium silicate (OMMS) is coated on plasma electrolytic oxidation (PEO)-modified titanium (Ti) substrate through electrophoretic deposition (EPD) and rifampin as an antibiotic is loaded on OMMS coating to be applied as an antibacterial coating...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
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