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Materials Science & Engineering. C, Materials for Biological Applications

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https://www.readbyqxmd.com/read/27772731/highly-lipophilic-pluronics-conjugated-polyamidoamine-dendrimer-nanocarriers-as-potential-delivery-system-for-hydrophobic-drugs
#1
Thi Tram Chau Nguyen, Cuu Khoa Nguyen, Thi Hiep Nguyen, Ngoc Quyen Tran
In the study, four kinds of pluronics (P123, F68, F127 and F108) with varying hydrophilic-lipophilic balance (HLB) values were modified and conjugated on 4th generation of polyamidoamine dendrimer (PAMAM). The obtained results from FT-IR, (1)H NMR and GPC showed that the pluronics effectively conjugated on the dendrimer. The molecular weight of four PAMAM G4.0-Pluronics and its morphologies are in range of 200.15-377.14kDa and around 60-180nm in diameter by TEM, respectively. Loading efficiency and release of hydrophobic fluorouracil (5-FU) anticancer drug were evaluated by HPLC; Interesting that the dendrimer nanocarrier was conjugated with the highly lipophilic pluronic P123 (G4...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772730/regulation-of-the-secretion-of-immunoregulatory-factors-of-mesenchymal-stem-cells-mscs-by-collagen-based-scaffolds-during-chondrogenesis
#2
Jingyu Yang, Xuening Chen, Tun Yuan, Xiao Yang, Yujiang Fan, Xingdong Zhang
In the latest decade, mesenchymal stem cells (MSCs) have wildly considered as a source of seeded cells in tissue engineering, not only because of its multi-differentiation potentials, but also due to its immunoregulation ability. The main immunoregulatory features of MSCs could be divided into low self-immunogenicity and secretion of soluble factors. In this study, we explored how scaffold structures modulated the secretion of soluble immunoregulatory factors in MSCs under an allogeneic cartilage tissue engineering background...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772729/low-temperature-deposition-manufacturing-a-novel-and-promising-rapid-prototyping-technology-for-the-fabrication-of-tissue-engineered-scaffold
#3
Wei Liu, Daming Wang, Jianghong Huang, You Wei, Jianyi Xiong, Weimin Zhu, Li Duan, Jielin Chen, Rong Sun, Daping Wang
Developed in recent years, low-temperature deposition manufacturing (LDM) represents one of the most promising rapid prototyping technologies. It is not only based on rapid deposition manufacturing process but also combined with phase separation process. Besides the controlled macropore size, tissue-engineered scaffold fabricated by LDM has inter-connected micropores in the deposited lines. More importantly, it is a green manufacturing process that involves non-heating liquefying of materials. It has been employed to fabricate tissue-engineered scaffolds for bone, cartilage, blood vessel and nerve tissue regenerations...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772728/effect-of-inorganic-organic-ratio-and-chemical-coupling-on-the-performance-of-porous-silica-chitosan-hybrid-scaffolds
#4
Daming Wang, Wei Liu, Qian Feng, Chaoqun Dong, Qisong Liu, Li Duan, Jianghong Huang, Weimin Zhu, Zemeng Li, Jianyi Xiong, Yujie Liang, Jielin Chen, Rong Sun, Liming Bian, Daping Wang
Inorganic/organic hybrid scaffolds have great potential for tissue engineering applications due to controllable mechanical properties and tailorable biodegradation. Here, silica/chitosan hybrid scaffolds were fabricated through the sol-gel method with a freeze drying process. 3-Glycidoxypropyl trimethoxysilane (GPTMS) and tetraethylorthosilicate (TEOS) were used as the covalent inorganic/organic coupling agent and the separate inorganic source, respectively. Hybrid scaffolds with various inorganic/organic weight ratios (I/Os) and molar ratios of chitosan and GPTMS (GCs) were examined and compared in this study...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772727/a-scaffold-filter-model-for-studying-the-chondrogenic-differentiation-of-stem-cells-in-vitro
#5
Ling Zhang, Li Zheng, Hong S Fan, Xing D Zhang
This study was undertaken to explore the synergistic effect of scaffold materials and a cartilage-like environment on the chondrogenic differentiation of stem cells. Because stem cells encapsulated in a cartilage scaffold will be induced by scaffold molecules as well as permeable molecules from the surroundings, it is impossible to optimize a chondro-inducible scaffold without considering environmental sensitivity. How do we know if a designed scaffold will be sufficient prior to implantation? In this study, bone marrow mesenchymal stem cells (bMSCs) were seeded in various scaffolds, including collagen hydrogel, collage/sodium alginate hydrogel, collagen sponge and silk fibroin sponge...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772726/effect-of-apatite-formation-of-biphasic-calcium-phosphate-ceramic-bcp-on-osteoblastogenesis-using-simulated-body-fluid-sbf-with-or-without-bovine-serum-albumin-bsa
#6
Li Huang, Bo Zhou, Huayu Wu, Li Zheng, Jinmin Zhao
Although biphasic calcium phosphate ceramic (BCP) holds promise in therapy of bone defect, surface mineralization prior to implantation may improve the bioactivity to better integrate with the host. Immersion in simulated body fluid (SBF) and bovine serum albumin-simulated body fluid (BSA-SBF) are common methods to form apatite interface layer. This study was intended to investigate the effect of SBF and BSA-SBF treatment on the bioactivity of BCP in vitro. In this study, osteoblasts were grown on BCP with or without treatment of SBF or BSA-SBF, and detected with general observation, scanning electron microscope (SEM), cell proliferation assay, morphology observation, viability assay, alkaline phosphatase (ALP) activity assay, and osteogenic specific gene expression of alkaline phosphatase (ALPL), bone gamma-carboxyglutamate (gla) protein (BGLAP), bone morphogenetic protein 2 (BMP2), bone sialoprotein (BSP), type I collagen (COLI) and runt-related transcription factor 2 (RUNX2) after culture of 2, 5 and 8days...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772725/hierarchical-self-assembly-of-heparin-peg-end-capped-porous-silica-as-a-redox-sensitive-nanocarrier-for-doxorubicin-delivery
#7
Thu Thao Nguyen Thi, Tuong Vi Tran, Ngoc Quyen Tran, Cuu Khoa Nguyen, Dai Hai Nguyen
Porous nanosilica (PNS) has been attracting a great attention in fabrication carriers for drug delivery system (DDS). However, unmodified PNS-based carriers exhibited the initial burst release of loaded bioactive molecules, which may limit their potential clinical application. In this study, the surface of PNS was conjugated with adamantylamine (A) via disulfide bonds (PNS-SS-A) which was functionalized with cyclodextrin-heparin-polyethylene glycol (CD-HPEG) for redox triggered doxorubicin (DOX) delivery. The modified PNS was successfully formed with spherical shape and diameter around 50nm determined by transmission electron microscopy (TEM)...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772724/nanodelivery-systems-for-enhancing-the-immunostimulatory-effect-of-cpg-oligodeoxynucleotides
#8
Huijie Zhang, Xiao-Dong Gao
Synthetic oligodeoxynucleotides containing immunostimulatory CpG motif mimic bacterial DNA and are potent activator of innate and adaptive immune responses. Therefore, CpG ODNs have significant potentials as immunotherapeutic agent for treatment of infectious diseases, allergy and cancer. Many clinical trials involving CpG ODNs either used alone or as adjuvant have been initiated. However, delivery of CpG ODNs to target sites still remains a great challenge due to their extreme susceptibility to nuclease degradation in serum and poor cellular uptake...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772723/special-issue-biomedical-applications-editorial
#9
Xian Jun Loh, Dan Kai
No abstract text is available yet for this article.
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772722/preparation-of-bioactive-%C3%AE-tricalcium-phosphate-microspheres-as-bone-graft-substitute-materials
#10
Bo Li, Zhongning Liu, Jingwen Yang, Zhongchao Yi, Wenqian Xiao, Xue Liu, Xiaoling Yang, Wenfeng Xu, Xiaoling Liao
In this study, β-tricalcium phosphate (Ca3PO4, β-TCP) microspheres with different diameters were fabricated via a solid-in-oil-in-water (S/O/W) emulsion method. After soaking in simulated body fluid (SBF), the fabricated β-TCP microspheres were fully covered with a new bone-like apatite layer; subsequent analysis suggested that the microspheres have excellent bioactivity properties, specifically in inducing apatite deposition. The calcium release profiles of the microspheres were tested in pH7.4 Tris-HCl buffer, and results demonstrated that the Ca(2+) continually released from microspheres during the two-week test period...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772721/an-improved-polymeric-sponge-replication-method-for-biomedical-porous-titanium-scaffolds
#11
Chunli Wang, Hongjie Chen, Xiangdong Zhu, Zhanwen Xiao, Kai Zhang, Xingdong Zhang
Biomedical porous titanium (Ti) scaffolds were fabricated by an improved polymeric sponge replication method. The unique formulations and distinct processing techniques, i.e. a mixture of water and ethanol as solvent, multiple coatings with different viscosities of the Ti slurries and centrifugation for removing the extra slurries were used in the present study. The optimized porous Ti scaffolds had uniform porous structure and completely interconnected macropores (~365.1μm). In addition, two different sizes of micropores (~45...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772720/recent-progress-of-atomic-layer-deposition-on-polymeric-materials
#12
Hong Chen Guo, Enyi Ye, Zibiao Li, Ming-Yong Han, Xian Jun Loh
As a very promising surface coating technology, atomic layer deposition (ALD) can be used to modify the surfaces of polymeric materials for improving their functions and expanding their application areas. Polymeric materials vary in surface functional groups (number and type), surface morphology and internal structure, and thus ALD deposition conditions that typically work on a normal solid surface, usually do not work on a polymeric material surface. To date, a large variety of research has been carried out to investigate ALD deposition on various polymeric materials...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772719/photosensitive-semiconducting-polymer-incorporated-nanofibers-for-promoting-the-regeneration-of-skin-wound
#13
Guorui Jin, Jun Li, Kai Li
Photosensitive semiconducting polymer (SP) combined with light stimulation has shown the capability in promoting the proliferation of human dermal fibroblasts (HDFs). However, the high cytotoxicity of the used SP hindered its further application in bioactive scaffolds. In this contribution, we designed and synthesized a SP, poly (N,N-bis(2-octyldodecyl)-3,6-di(thiophen-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione-alt-thieno[3,2-b]thiophene) (PDBTT) with low cytotoxicity and strong absorbance in red and near-infrared region (600-1200nm)...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772718/controlling-cell-adhesion-using-layer-by-layer-approaches-for-biomedical-applications
#14
Shanshan Guo, Xiaoying Zhu, Xian Jun Loh
Controlling the adhesion of mammalian and bacterial cells at the interfaces between synthetic materials and biological environments is a real challenge in the biomedical fields such as tissue engineering, antibacterial coating, implantable biomaterials and biosensors. The surface properties of materials are known to profoundly influence the adhesion processes. To mediate the adhesion processes, polymeric coatings have been used to functionalize surfaces to introduce diverse physicochemical properties. The polyelectrolyte multilayer films built via the layer-by-layer (LbL) method, introduced by Moehwald, Decher, and Lvov 20years ago, has led to significant developments ranging from the fundamental understanding of cellular processes to controlling cell adhesion for biomedical applications...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772717/role-of-electrostatic-complementarity-between-perylenediimide-and-porphyrin-in-highly-stabilized-gna
#15
Yonggang Xiang, Qingye Zhang, Zibiao Li, Hao Chen
Relatively electron-deficient perylenediimide (PDI) and relatively electron-rich porphyrin (Por) were introduced into the middle of 16-mer glycol nucleic acid (GNA), and up to five consecutive chromophores were arranged in the zipper-like interstrand alternating fashion. Remarkable variation for the CD spectra ascribed to chromophores was observed, and bathochromic shift in the UV/Vis absorption region of chromophores occurred upon duplex formation. Interestingly, zipper-like heteroaggregates of chromophores inside had marvelous positive effects on the stabilization of the duplex, Tm of Por-PDI-Por sandwich-type modified GNA duplex was increased by 24°C in comparison with three A-T base pairs, moreover, Por-PDI-Por-PDI-Por interstrand modified GNA duplex was even stabilized by 25°C in replacement of five A-T base pairs...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772716/uniformly-dispersed-nanohydroxapatite-reinforced-poly-%C3%AE%C2%B5-caprolactone-composite-films-for-tendon-tissue-engineering-application
#16
Shi Yun Tong, Zuyong Wang, Poon Nian Lim, Wilson Wang, Eng San Thian
Regeneration of injuries at tendon-to-bone interface (TBI) remains a challenging issue due to the complex tissue composition involving both soft tendon tissues and relatively hard bone tissues. Tissue engineering using polymeric/ceramic composites has been of great interest to generate scaffolds for tissue's healing at TBI. Herein, we presented a novel method to blend polymers and bioceramics for tendon tissue engineering application. A homogeneous composite comprising of nanohydroxyapatite (nHA) particles in poly(ε-caprolactone) (PCL) matrix was obtained using a combination of solvent and mechanical blending process...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772715/sequential-coating-upconversion-nayf4-yb-tm-nanocrystals-with-sio2-and-zno-layers-for-nir-driven-photocatalytic-and-antibacterial-applications
#17
Meijie Tou, Zhenguo Luo, Song Bai, Fangying Liu, Qunxia Chai, Sheng Li, Zhengquan Li
ZnO is one of the most promising materials for both photocatalytic and antibacterial applications, but its wide bandgap requires the excitation of UV light which limits their applications under visible and NIR bands. Herein, we demonstrate a facile approach to synthesize core-shell-shell hybrid nanoparticles consisting of hexagonal NaYF4:Yb,Tm, amorphous SiO2 and wurtzite ZnO. The upconversion nanocrystals are used as the core seeds and sequentially coated with an insulting shell and a semiconductor layer. Such hybrid nanoparticles can efficiently utilize the NIR light through the upconverting process, and display notable photocatalytic performance and antibacterial activity under NIR irradiation...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772714/necl1-coated-plga-as-favorable-conduits-for-repair-of-injured-peripheral-nerve
#18
Fuben Xu, Kun Zhang, Peizhen Lv, Rongbin Lu, Li Zheng, Jinmin Zhao
Restoration of normal neurological function of transected peripheral nerve challenged regenerative medicine and surgery. Previous studies showed that Nectin-like molecule 1 (NECL1) is one of the important adhesion molecules on the axons and Schwann cells is located along the internodes in direct apposition to NECL1. In this study, we fabricated PLGA membrane pre-coated with NECL1, mimicking the natural axons to enhance the adhesion of Schwann cells. Investigation of the cellular response in vitro was performed by detecting cytotoxicity, proliferation, morphology, viability, specific markers and Scanning Electron Microscopy (SEM) of Schwann cells cultured in PLGA...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772713/preparation-of-polymer-calcium-phosphate-porous-composite-as-bone-tissue-scaffolds
#19
Zhuo Kang, Xueqin Zhang, Yongquan Chen, Muhammad Yasir Akram, Jun Nie, Xiaoqun Zhu
Composite scaffolds, especially polymer/calcium phosphate composite scaffolds with porous structures are promising materials for bone tissue engineering. Depositing minerals on the surface of polymer scaffolds is a general method however, attachment between inorganic minerals and organic polymeric is a big challenge, because of the absence of strong interactions between the interfaces. In this work, polymer/calcium phosphate composite scaffolds with good attachment were fabricated through introduction of calcium and alternate mineralization...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27772712/hydrolytic-conversion-of-amorphous-calcium-phosphate-into-apatite-accompanied-by-sustained-calcium-and-orthophosphate-ions-release
#20
Xufeng Niu, Siqian Chen, Feng Tian, Lizhen Wang, Qingling Feng, Yubo Fan
The aim of this study is to investigate the calcium and orthophosphate ions release during the transformation of amorphous calcium phosphate (ACP) to hydroxyapatite (HA) in aqueous solution. The ACP is prepared by a wet chemical method and further immersed in the distilled water for various time points till 14d. The release of calcium and orthophosphate ions is measured with calcium and phosphate colorimetric assay kits, respectively. The transition of ACP towards HA is detected by x-ray diffraction (XRD), transmission electron microscopy (TEM), and fourier transform infrared spectroscopy (FTIR)...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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