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Materials Science & Engineering. C, Materials for Biological Applications

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https://www.readbyqxmd.com/read/28024644/impact-of-macromolecular-crowding-on-structure-and-properties-of-pepsin-and-trypsin
#1
Wala Gtari, Houda Bey, Adel Aschi, Lotfi Bitri, Tahar Othman
The change of conformation of pepsin and trypsin in absence and presence of a high molecular crowding agent has been characterized using dynamic light scattering (DLS). Structural properties were investigated as a function of chemical denaturant concentrations, the guanidine hydrochloride (GdmCl). The results showed that Ficoll 400, macromolecular crowding, has a strong effect on the chemical denaturation process of these two proteins. The changes of measured hydrodynamic radius are attributed to the enhancement effect of the crowder agent due to the excluded volume effects...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024643/facile-and-innovative-method-for-bioglass-surface-modification-optimization-studies
#2
João Henrique Lopes, Emanuella Maria Barreto Fonseca, Italo O Mazali, Alviclér Magalhães, Richard Landers, Celso Aparecido Bertran
In this work it is presented a facile and novel method for modification of bioglass surface based on (Camolten salt bath(2+)|Naglass(+)) ion exchange by immersion in molten salt bath. This method allows changing selectively the chemical composition of a surface layer of glass, creating a new and more reactive bioglass in a shell that surrounds the unchanged bulk of the original BG45S5 bioglass (core-shell type system). The modified bioglass conserves the non-crystalline structure of BG45S5 bioglass and presents a significant increase of surface reactivity in comparison with BG45S5...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024642/a-theranostic-prodrug-based-on-fret-for-real-time-drug-release-monitoring-in-response-to-biothiols
#3
Yinyang Hu, Fang Zeng
The clinical applications of tradition prodrug are restricted to a certain extent due to its some defects such as side effects, low selectivity and single function. Herein, we designed a theranostic strategy based on the fluorescence resonance energy transfer (FRET) mechanism. The theranostic prodrug was constructed with an anticancer drug camptothecin (CPT), a cleavable linker based on disulfide bonds (SS) and a fluorophore naphthalimide derivative (NAP). For this drug delivery and reporting system (NAP-SS-CPT), FRET occurs between CPT (energy donor) and NAP (energy receptor); and upon cellular uptake by GSH-overexpressing cancer cells, disulfide bonds could be successfully cleaved by the high concentration of GSH, and FRET process was interrupted to achieve dual fluorescence response and specifically release of CPT...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024641/poly-amido-amine-and-nano-calcium-phosphate-bonding-agent-to-remineralize-tooth-dentin-in-cyclic-artificial-saliva-lactic-acid
#4
Kunneng Liang, Michael D Weir, Mark A Reynolds, Xuedong Zhou, Jiyao Li, Hockin H K Xu
The objectives of this study were to develop a novel method to remineralize dentin lesions, and investigate the remineralization effects of poly (amido amine) (PAMAM) dendrimer plus a bonding agent with nanoparticles of amorphous calcium phosphate (NACP) in a cyclic artificial saliva/lactic acid environment for the first time. Dentin lesions were produced via phosphoric acid. Four groups were tested: (1) dentin control, (2) dentin with PAMAM, (3) dentin with NACP bonding agent, and (4) dentin with PAMAM plus NACP bonding agent...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024640/graphene-oxide-directed-in-situ-synthesis-of-prussian-blue-for-non-enzymatic-sensing-of-hydrogen-peroxide-released-from-macrophages
#5
Weiwei Qiu, Qionghua Zhu, Fei Gao, Feng Gao, Jiafu Huang, Yutian Pan, Qingxiang Wang
A novel electrochemical non-enzymatic hydrogen peroxide (H2O2) sensor has been developed based on Prussian blue (PB) and electrochemically reduced graphene oxide (ERGO). The GO was covalently modified on glassy carbon electrode (GCE), and utilized as a directing platform for in-situ synthesis of electroactive PB. Then the GO was electrochemically treated to reduction form to improve the effective surface area and electroactivity of the sensing interface. The fabrication process was characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024639/soluble-telmisartan-bearing-poly-ethylene-glycol-conjugated-chitosan-nanoparticles-augmented-drug-delivery-cytotoxicity-apoptosis-and-cellular-uptake-in-human-cervical-cancer-cells
#6
Anjali Sharma, Kiran Jyoti, Vikas Bansal, Upendra Kumar Jain, Bharat Bhushan, Jitender Madan
Soluble telmisartan and telmisartan were loaded in to poly (ethylene-glycol) grafted chitosan nanoparticles (S-TEL-PEG-CNPs and TEL-PEG-CNPs) for targeting cervical cancer through non-invasive, intravaginal route. The mean particle size of S-TEL-PEG-CNPs was measured to be 23.4±5.9-nm significantly (P<0.05) higher than 16.2±3.2-nm of TEL-PEG-CNPs. In contrast, the zeta-potential (-21.5±4.6-mV) of S-TEL-PEG-CNPs was insignificantly (P>0.05) different from -23.8±3.7-mV of TEL-PEG-CNPs. In addition, S-TEL-PEG-CNPs exhibited higher percent mucoadhesiveness (40...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024638/sulfonated-chitosan-and-dopamine-based-coatings-for-metallic-implants-in-contact-with-blood
#7
Clayton S Campelo, Pascale Chevallier, Juliana M Vaz, Rodrigo S Vieira, Diego Mantovani
Thrombosis and calcification constitute the main clinical problems when blood-interacting devices are implanted in the body. Coatings with thin polymer layers represent an acknowledged strategy to modulate interactions between the material surface and the blood environment. To ensure the implant success, at short-term the coating should limit platelets adhesion and delay the clot formation, and at long-term it should delay the calcification process. Sulfonated chitosan, if compared to native chitosan, shows the unique ability to reduce proteins adsorption, decrease thrombogenic properties and limit calcification...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024637/effect-of-ca-p-ratio-on-the-structural-and-corrosion-properties-of-biomimetic-cap-coatings-on-zk60-magnesium-alloy
#8
Kada Xia, Hui Pan, Taolei Wang, Shangjun Ma, Junchao Niu, Zhen Xiang, Yiming Song, Huawei Yang, Xiaoshan Tang, Wei Lu
Magnesium and its alloys have attracted much attention as metallic biodegradable implants for their excellent biocompatibility and mechanical properties. However, magnesium has a poor corrosion resistance, causing its rapid degrading in vivo via an electrochemical reaction, which has become a major obstacle to their applications in implants. In this work, CaP coating was successfully coated on the ZK60 magnesium alloys by a simple hydrothermal deposition method. The mechanisms of the hydrothermal reactions of CaP coatings on Mg substrate are described in details...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024636/spectroscopic-and-tddft-investigation-on-highly-selective-fluorogenic-chemosensor-and-construction-of-molecular-logic-gates
#9
Sabeel M Basheer, Saravana Loganathan Ashok Kumar, Moorthy Saravana Kumar, Anandaram Sreekanth
1,5-Bis(2-fluorene)thiocarbohydrazone (FBTC) was designed and synthesized for selective sensing of fluoride and copper ions. The binding constants of FBTC towards fluoride and copper ions have been calculated using the Benesi-Hildebrand equation, and FBTC has more binding affinity towards copper ion than fluoride ion. The (1)H NMR and (13)C NMR titration studies strongly support the deprotonation was taken from the N-H protons followed by the formation of hydrogen bond via N-H(…)F. To understand the fluoride ion sensing mechanism, theoretical investigation had been carried out using the density functional theory and time-dependent density functional theory...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024635/the-rational-designed-graphene-oxide-fe2o3-composites-with-low-cytotoxicity
#10
Dong Yan, Haiyan Zhao, Jiayun Pei, Xin Wu, Yue Liu
Novel two-dimensional materials with a layered structure are of special interest for a variety of promising applications. In current research, the nanostructured graphene oxide-Fe2O3 composite (GO-Fe2O3) was firstly obtained via a carefully elaborated approach of vacuum freeze-drying. The scanning electron microscopy (SEM) and transmission electron microscope (TEM) images revealed that α-Fe2O3 nanoparticles loaded well on the surfaces of graphene. A series of characterization were performed to further elucidate the as-obtained nanomaterial's physicochemical properties...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024634/biocompatibility-of-sol-gel-hydroxyapatite-titania-composite-and-bilayer-coatings
#11
D Sidane, H Rammal, A Beljebbar, S C Gangloff, D Chicot, F Velard, H Khireddine, A Montagne, H Kerdjoudj
Titania-Hydroxyapatite (TiO2/HAP) reinforced coatings are proposed to enhance the bioactivity and corrosion resistance of 316L stainless steel (316L SS). Herein, spin- and dip-coating sol-gel processes were investigated to construct two kinds of coatings: TiO2/HAP composite and TiO2/HAP bilayer. Physicochemical characterization highlighted the bioactivity response of the TiO2/HAP composite once incubated in physiological conditions for 7days whereas the TiO2/HAP bilayer showed instability and dissolution. Biological analysis revealed a failure in human stem cells adhesion on TiO2/HAP bilayer whereas on TiO2/HAP composite the presence of polygonal shaped cells, possessing good behaviour attested a good biocompatibility of the composite coating...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024633/novel-impedimetric-dopamine-biosensor-based-on-boronic-acid-functional-polythiophene-modified-electrodes
#12
Muamer Dervisevic, Mehmet Senel, Emre Cevik
In this study we report a new, simple and first impedimetric biosensor based on 3-Thienyl boronic acid for dopamine detection. Biosensor electrode preparation is 1min long by simple electro-polymerization of 3-Thienyl boronic acid and copolymer Thiophene P(TBA0.50Th0.50). Strong interaction between dopamine and thin layer of boronic acid has provided bio-sensing electrode high selectivity and stability, linear range of 7.8 to 125μM, and detection limit of 0.3μM. Characterization and optimization studies were conducted using electrochemical impedance spectroscopy (EIS) and cyclic voltammogram (CV)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024632/preliminary-study-on-the-corrosion-resistance-antibacterial-activity-and-cytotoxicity-of-selective-laser-melted-ti6al4v-xcu-alloys
#13
Sai Guo, Yanjin Lu, Songquan Wu, Lingling Liu, Mengjiao He, Chaoqian Zhao, Yiliang Gan, Junjie Lin, Jiasi Luo, Xiongcheng Xu, Jinxin Lin
In this study, a series of Cu-bearing Ti6Al4V-xCu (x=0, 2, 4, 6wt%) alloys (shorten by Ti6Al4V, 2C, 4C, and 6C, respectively.) with antibacterial function were successfully fabricated by selective laser melting (SLM) technology with mixed spherical powders of Cu and Ti6Al4V for the first time. In order to systematically investigate the effects of Cu content on the microstructure, phase constitution, corrosion resistance, antibacterial properties and cytotoxicity of SLMed Ti6Al4V-xCu alloys, experiments including XRD, SEM-EDS, electrochemical measurements, antibacterial tests and cytotoxicity tests were conducted with comparison to SLMed Ti6Al4V alloy (Ti6Al4V)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024631/gold-nanoparticle-filled-biodegradable-photopolymer-scaffolds-induced-muscle-remodeling-in-vitro-and-in-vivo-findings
#14
Adam Zsedenyi, Balazs Farkas, Gaser N Abdelrasoul, Ilaria Romano, Edina Gyukity-Sebestyen, Katalin Nagy, Maria Harmati, Gabriella Dobra, Sandor Kormondi, Gabor Decsi, Istvan Balazs Nemeth, Alberto Diaspro, Fernando Brandi, Szabolcs Beke, Krisztina Buzas
Therapeutic stem cell transplantation bears the promise of new directions in organ and tissue replacement, but a number of its difficulties and perils are also well known. Our goal was to develop a method of transplantation by which the transplanted cells remain confined to the transplantation site and induce favorable processes. With the help of mask-projection excimer laser stereolithography, 3D hybrid nanoscaffolds were fabricated from biodegradable, photocurable PPF:DEF resin with incorporated gold nanoparticles (Au NPs)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024630/kinetics-of-deposition-and-stability-of-pyrocatechol-feiii-coordinated-films
#15
Claire Meyer, Florian Ponzio, Eric Mathieu, Vincent Ball
Metal coordination between polyphenols and metal cations like Fe(3+) allows to produce conformal homogeneous and robust coatings on a vast variety of materials. The deposition kinetics and the stability of the obtained films are however only poorly investigated. In the present article it is shown that rough, granular but pinhole free coatings up to 50nm in thickness can be obtained in a one pot manner using pyrocatechol (Pyr)/Fe(3+) mixtures at different stoichiometries (with Fe(3+)/Pyr ratios equal to 0.55 or 1...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024629/low-temperature-thermal-reduction-of-suspended-graphene-oxide-film-for-electrical-sensing-of-dna-hybridization
#16
Tun Wang, Hong-Chen Guo, Xin-Yi Chen, Miao Lu
A reduced graphene oxide (RGO) based capacitive real time bio-sensor was presented. Suspended graphene oxide (GO) film was assembled electrophoretically between the source and drain electrodes of a transistor and then reduced by annealing in hydrogen/nitrogen forming gas to optimize the surface functional groups and conductivity. The resonance frequency of the transmission coefficient (S21) of the transistor was observed to shift with deoxyribonucleic acid (DNA)-hybridization, with a detecting limit of ~5nM...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024628/polypropyleneimine-and-polyamidoamine-dendrimer-mediated-enhanced-solubilization-of-bortezomib-comparison-and-evaluation-of-mechanistic-aspects-by-thermodynamics-and-molecular-simulations
#17
Sonam Chaudhary, Avinash Gothwal, Iliyas Khan, Shubham Srivastava, Ruchi Malik, Umesh Gupta
Bortezomib (BTZ) is the first proteasome inhibitor approved by the US-FDA is majorly used for the treatment of newly diagnosed and relapsed multiple myeloma including mantle cell lymphoma. BTZ is hydrophobic in nature and is a major cause for its minimal presence as marketed formulations. The present study reports the design, development and characterization of dendrimer based formulation for the improved solubility and effectivity of bortezomib. The study also equally focuses on the mechanistic elucidation of solubilization by two types of dendrimers i...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024627/fretting-corrosion-behavior-of-nitinol-spinal-rods-in-conjunction-with-titanium-pedicle-screws
#18
Elena Lukina, Mikhail Kollerov, Jay Meswania, Alla Khon, Pavel Panin, Gordon W Blunn
Untypical corrosion damage including erosions combined with the build-up of titanium oxide as a corrosion product on the surface of explanted Nitinol spinal rods in the areas where it was in contact with titanium pedicle screw head is reported. It was suggested that Nitinol rods might have inferior fretting corrosion resistance compared with that made of titanium or CoCr. Fretting corrosion of Nitinol spinal rods with titanium (Ti6Al4V) pedicle screws were tested in-vitro by conducting a series of potentiostatic measurements of the peak-to-peak values of fretting corrosion current under bending in a 10% solution of calf serum in PBS...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024626/self-assembly-of-aromatic-%C3%AE-amino-acids-into-amyloid-inspired-nano-micro-scaled-architects
#19
Prabhjot Singh, Surinder K Brar, Manish Bajaj, Nikesh Narang, Venus S Mithu, Om P Katare, Nishima Wangoo, Rohit K Sharma
In the pursuit for design of novel bio inspired materials, aromatic α-amino acids (phenylalanine, tyrosine, tryptophan and histidine) have been investigated for the generation of well-ordered self-assembled architects such as fibrils, rods, ribbons and twisted nanosheets in varying solvent systems. These nano/micro scaled architects were thoroughly characterized using FE-SEM, confocal microscopy, optical microscopy, (1)H NMR, FTIR, XRD and TGA. These self-assembled architects were histologically stained with Congo red and thioflavin T dyes for investigation of amyloid morphology which revealed that the deposited state of ordered assemblies exhibit specific characteristic of amyloid deposits...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024625/development-of-simple-and-sensitive-hydrogel-based-colorimetric-sensor-array-for-the-real-time-quantification-of-gaseous-ammonia
#20
Sanduru Thamarai Krishnan, Kuk Hui Son, Namhyoung Kim, Buddolla Viswanath, Sanghyo Kim, Jeong Ho An
A real-time colorimetric sensor array (CSA) offers the advantages of diversity and accuracy for the quantification of multiple analytes; however, traditional sensors require a complex fabrication process. Therefore, to take full advantage of this sensing platform, we have developed a simple CSA system composed of a polymer, a reducing agent, and different pH indicators. Distinctive color response patterns were classified by extracting the hidden information, (i.e., red, green, and blue (RGB) values) from the indicators...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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