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Materials Science & Engineering. C, Materials for Biological Applications

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https://www.readbyqxmd.com/read/28629101/a-mini-review-on-hydrogels-classification-and-recent-developments-in-miscellaneous-applications
#1
REVIEW
Kokkarachedu Varaprasad, Gownolla Malegowd Raghavendra, Tippabattini Jayaramudu, Murali Mohan Yallapu, Rotimi Sadiku
Hydrogels are composed of three-dimensional smart and/or hungry networks, which do not dissolve in water but swell considerably in an aqueous medium, demonstrating an extraordinary ability to absorb water into the reticulated structure. Such inherent feature is a subject of considerable scientific research interest which leads to a dominating path in extending their potential in hi-tech applications. Over the past decades, significant progress has been made in the field of hydrogels. Further, explorations are continuously being made in all directions at an accelerated pace for their extensive usage...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629100/biomaterials-and-cells-for-cardiac-tissue-engineering-current-choices
#2
REVIEW
Rusha Chaudhuri, Madhumitha Ramachandran, Pearl Moharil, Megha Harumalani, Amit K Jaiswal
The major purpose of cardiac tissue engineering is to engineer cells on scaffolds and use it as a substitute to infarcted cardiac cells. With an ever-increasing risk of cardiac diseases there is an increasing need to have a stable and sustainable approach to cure such ailments. This review provides a comprehensive update on the cell sources and biomaterials essential for cardiac tissue engineering, ensuring their biocompatibility under a variety of conditions. Cells can be obtained from allogenic or autologous sources...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629099/instrumental-methods-and-techniques-for-structural-and-physicochemical-characterization-of-biomaterials-and-bone-tissue-a-review
#3
REVIEW
Žarko Mitić, Aleksandra Stolić, Sanja Stojanović, Stevo Najman, Nenad Ignjatović, Goran Nikolić, Miroslav Trajanović
A review of recent advances in instrumental methods and techniques for structural and physicochemical characterization of biomaterials and bone tissue is presented in this paper. In recent years, biomaterials attracted great attention primarily because of the wide range of biomedical applications. This paper focuses on the practical aspects of instrumental methods and techniques that were most often applied (X-ray methods, vibrational spectroscopy (IR and Raman), magnetic-resonance spectroscopy (NMR and ESR), mass spectrometry (MS), atomic absorption spectrometry (AAS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES), thermogravimetry (TG), differential thermal analysis (DTA) and differential scanning calorimetry (DSC), scanning electron microscopy (SEM), transmission electron microscopy (TEM)) in the structural investigation and physicochemical characterization of biomaterials and bone tissue...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629098/carbon-nanotube-ensembled-hybrid-nanocomposite-electrode-for-direct-electrochemical-detection-of-epinephrine-in-pharmaceutical-tablets-and-urine
#4
K Koteshwara Reddy, M Satyanarayana, K Yugender Goud, K Vengatajalabathy Gobi, Hern Kim
An efficient electrochemical sensor for selective detection of the neurotransmitter, epinephrine (Epn), has been fabricated with the aid of a functionalized multiwall carbon nanotube-chitosan biopolymer nanocomposite (Chit-fCNT) electrode. Multiwall carbon nanotubes (CNT) were successfully functionalized with the aid of nitric acid and confirmed by the Raman spectral data. Functionalized carbon nanotubes (fCNT) were dispersed in chitosan solution and the resulting bio-nanocomposite was used for the fabrication of sensor surface by drop and cast method...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629097/emerging-bone-tissue-engineering-via-polyhydroxyalkanoate-pha-based-scaffolds
#5
REVIEW
Janice Lim, Mingliang You, Jian Li, Zibiao Li
Polyhydroxyalkanoates (PHAs) are a class of biodegradable polymers derived from microorganisms. On top of their biodegradability and biocompatibility, different PHA types can contribute to varying mechanical and chemical properties. This has led to increasing attention to the use of PHAs in numerous biomedical applications over the past few decades. Bone tissue engineering refers to the regeneration of new bone through providing mechanical support while inducing cell growth on the PHA scaffolds having a porous structure for tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629096/synthesis-of-magnetic-nanoparticles-and-their-dispersions-with-special-reference-to-applications-in-biomedicine-and-biotechnology
#6
REVIEW
R V Mehta
Biomedical and biotechnological applications of magnetic nanoparticles and their dispersions in liquids are found to be potentially useful. An exponential growth in publications of papers, reviews and patents has been observed. Possibilities of their indiscriminate use on individual as well as environmental health hazards are also investigated. Still, there appears to be a good scope for further research work in the field. Even a small improvement either in preparation method or development of novel nanoparticles may prove to be beneficial in longer run...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629095/solvothermal-synthesis-of-hydroxyapatite-nanorods-with-assistance-of-green-polymer
#7
Hui Yang, Tongxiang Liang, Xiaopeng Qi, Honghui Jiang, Yiqun Deng, Ping Wang, Huichang Gao
Development of low cost, environmental friendly crystal growth modifying reagents that are effective to HAp's microstructure regulation is highly crucial. Herein, sodium lignin sulfonate (SS), a byproduct of the pulp process, was used for preparing HAp nanorods. Results showed that both stirring time of reaction solution and the concentration of SS affected crystals' structure and aspect ratio. The growth mechanism was discussed on the basis of the results. And we hope this new synthetic strategy will offer an attractive route for the design of functional HAp nano-/micro- materials with fine structure...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629094/study-on-the-injectability-of-a-novel-glucose-modified-magnesium-potassium-phosphate-chemically-bonded-ceramic
#8
Yongshan Tan, Jinmei Dong, Hongfa Yu, Ying Li, Jing Wen, Chengyou Wu
A novel magnesium potassium phosphate chemically bonded ceramic (MKPCBC) was prepared as a byproduct of boron-containing magnesium oxide (B-MgO) after extracting Li2CO3 from salt lakes. In this work, the influence of glucose on the properties of MKPCBC, such as the setting time, compressive strength and hydration heat, was investigated. In addition, we studied the effect of the magnesium-phosphate ratio (M/P) and liquid-solid ratio (L/S) on the injectability of MKPCBC. The pH change in glucose modified MKPCBC paste was also investigated...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629093/novel-pemulen-pullulan-blended-hydrogel-containing-clotrimazole-loaded-cationic-nanocapsules-evaluation-of-mucoadhesion-and-vaginal-permeation
#9
Julia A de Lima, Thamiris C Paines, Mariana H Motta, Watussi B Weber, Sara S Dos Santos, Letícia Cruz, Cristiane de B da Silva
In this work, hydrogels containing clotrimazole-loaded nanocapsules were developed through the innovative association of two mucoadhesive polymers: Pemulen® TR1 and Pullulan. Furthermore, the hydrogels macroscopic characteristics, pH and spreadability were evaluated. The formulations showed homogeneous appearance and pH compatible with vaginal application (around 5.0). Similar spreadability profiles were found in hydrogels containing clotrimazole-loaded nanocapsules and in the free drug as well. Hydrogels were evaluated considering their mucoadhesive potential by the falling liquid film method and the permeation/penetration capacity through cow vaginal mucosa in Franz cell...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629092/binary-functional-porous-multi-mineral-substituted-apatite-nanoparticles-for-reducing-osteosarcoma-colonization-and-enhancing-osteoblast-cell-proliferation
#10
Dharman Govindaraj, Chandramohan Govindasamy, Mariappan Rajan
We investigated the use of combined nanoparticles in bone replacement for patients with bone cancer. Bismuth (Bi) is known to have antitumor effects, and the inclusion of Bi in bioactive mineral (M)-substituted hydroxyapatite (M-HAP) may provide anti-cancer properties implant resources. A series of Bi-substituted M-HAP (Bi-M-HAP) nanoparticles with various Bi concentrations was synthesized via the ultrasound irradiation method. The nanoparticles were examined using physicochemical strategies. The cell-substance interface of the nanoparticles was observed in vitro with human osteosarcoma cells and cell multiplication was measured at 1, 3, and 7days of incubation and in vivo in rats after 3weeks of implantation...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629091/polyurethane-silica-hybrid-foams-from-a-one-step-foaming-reaction-coupled-with-a-sol-gel-process-for-enhanced-wound-healing
#11
Eun-Ho Song, Seol-Ha Jeong, Ji-Ung Park, Sukwha Kim, Hyoun-Ee Kim, Juha Song
Polyurethane (PU)-based dressing foams have been widely used due to their excellent water absorption capability, optimal mechanical properties, and unequaled economic advantage. However, the low bioactivity and poor healing capability of PU limit the applications of PU dressings in complex wound healing cases. To resolve this problem, this study was carried out the hybridization of bioactive silica nanoparticles with PU through a one-step foaming reaction that is coupled with the sol-gel process. The hybridization with silica did not affect the intrinsically porous microstructure of PU foams with silica contents of up to 10wt% and where 5-60nm silica nanoparticles were well dispersed in the PU matrix, despite slight agglomerations...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629090/low-temperature-direct-heterogeneous-bonding-of-polyether-ether-ketone-and-platinum
#12
Weixin Fu, Akitsu Shigetou, Shuichi Shoji, Jun Mizuno
Direct heterogeneous bonding between polyether ether ketone (PEEK) and Pt was realized at the temperatures lower than 150°C. In order to create sufficient bondability to diverse materials, the surface was modified by vacuum ultraviolet (VUV) irradiation, which formed hydrate bridges. For comparison, direct bonding between surfaces atomically cleaned via Ar fast atom bombardment (FAB) was conducted in a vacuum. The VUV irradiation was found to be effective for creating an ultrathin hydrate bridge layer from the residual water molecules in the chamber...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629089/assembly-of-chitosan-support-matrix-with-gallic-acid-functionalized-nanoparticles
#13
J Lamarra, L Giannuzzi, S Rivero, A Pinotti
The incorporation of gallic acid (GA) in a direct way or into nanoparticles included in chitosan edible films appears as a suitable approach to increase its preservation upon adverse conditions. The addition of nanoparticles to chitosan-based matrices resulted in improvements in their solubility, swelling, and mechanical properties. It is worth noting that by means of the nanoencapsulation, the release process can be modulated in relation to the delivery of GA included directly in the matrix, releasing the agent at a lower rate for a longer time...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629088/encapsulation-of-methotrexate-and-cyclophosphamide-in-interpolymer-complexes-formed-between-poly-acrylic-acid-and-poly-ethylene-glycol-on-multi-walled-carbon-nanotubes-as-drug-delivery-systems
#14
Mohammad Hossein Ahmadi Azqhandi, Bahman Vasheghani Farahani, Nasibe Dehghani
By combining the advantage of multi-walled carbon nanotubes (MWCNTs) and interpolymer complexes, we synthesis a new carrier system consist of poly(acrylic acid)/poly(ethylene glycol)/carbon nanotube (PAA/PEG/CNT). Then, Methotrexate (MTX) and Cyclophosphamide (CPP) were loaded on PAA/PEG/CNT, and the physicochemical properties of nanoparticles characterized by Infrared spectroscopy (IR), Scanning Electron Microscopy (SEM), Thermo Gravimetric Analysis (TGA) and Nuclear Magnetic Resonance (NMR). In the second part after efficiency determination of loaded drugs, in vitro drug release study was examined with ultra violet spectroscopy (UV) in pH=7...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629087/a-novel-candidate-for-wound-dressing-transparent-porous-maghemite-cellulose-nanocomposite-membranes-with-controlled-release-of-doxorubicin-from-a-simple-approach
#15
Hao Zhang, Xiaogang Luo, Hu Tang, Mingming Zheng, Fenghong Huang
The aim of this study is to develop transparent maghemite/cellulose nanocomposite membranes with high porosity, high adsorption capacity and controlled release of doxorubicin to be used as a candidate for wound dressing. The membranes were fabricated by a tape casting method through blending a homogeneous dispersion of citrate coated maghemite nanoparticles and cellulose in the NaOH/urea aqueous solution system. The prepared membranes were characterized by Light transmittance measurements, Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray Diffractometry (XRD), Differential scanning calorimetry (DSC), Tensile tests and Vibrating sample magnetometer (VSM)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629086/enhancing-internalization-of-silica-particles-in-myocardial-cells-through-surface-modification
#16
Nancy Ornelas-Soto, Rodrigo Rubio-Govea, Carlos E Guerrero-Beltrán, Eduardo Vázquez-Garza, Judith Bernal-Ramírez, Alejandra García-García, Yuriana Oropeza-Almazán, Gerardo García-Rivas, Flavio F Contreras-Torres
Surface modification in nanostructured mesoporous silica particles (MSNs) can significantly increase the uptake in myocardial cells. Herein, MSNs particles were synthesized and chemically functionalized to further assess their biocompatibility in rat myocardial cell line H9c2. The surface modification resulted in particles with an enhanced cellular internallization (3-fold increase) with respect to pristine particles. Apoptosis events were not evident at all, while necrosis incidence was significant only at a higher doses (>500μg/mL)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629085/design-of-a-hybrid-biomaterial-for-tissue-engineering-biopolymer-scaffold-integrated-with-an-autologous-hydrogel-carrying-mesenchymal-stem-cells
#17
Caroline R Weinstein-Oppenheimer, Donald I Brown, Rodrigo Coloma, Patricio Morales, Mauricio Reyna-Jeldes, María J Díaz, Elizabeth Sánchez, Cristian A Acevedo
Biologically active biomaterials as biopolymers and hydrogels have been used in medical applications providing favorable results in tissue engineering. In this research, a wound dressing device was designed by integration of an autologous clot hydrogel carrying mesenchymal stem-cells onto a biopolymeric scaffold. This hybrid biomaterial was tested in-vitro and in-vivo, and used in a human clinical case. The biopolymeric scaffold was made with gelatin, chitosan and hyaluronic acid, using a freeze-drying method...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629084/facilitation-of-transscleral-drug-delivery-by-drug-loaded-magnetic-polymeric-particles
#18
Zeynab Mousavikhamene, Mohammad J Abdekhodaie, Hamid Ahmadieh
A unique method was used to facilitate ocular drug delivery from periocular route by drug loaded magnetic sensitive particles. Injection of particles in periocular space along the eye axis followed by application of magnetic field in front of the eye would trigger the magnetic polymeric particles to move along the direction of magnetic force and reside against the outer surface of the sclera. This technique prevents removal of drug in the periocular space, observed in conventional transscleral drug delivery systems and hence higher amount of drug can enter the eye in a longer period of time...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629083/effects-on-insulin-adsorption-due-to-zinc-and-strontium-substitution-in-hydroxyapatite
#19
Luisa A Scudeller, Elena Mavropoulos, Marcelo N Tanaka, Andrea M Costa, Carolina A C Braga, Elvis O López, Alexandre Mello, Alexandre M Rossi
Insulin-loaded calcium phosphate nanoparticles have been proposed as a potential drug delivery system for the oral treatment of diabetes and to stimulate bone cell proliferation and bone mineralization. The kinetics of insulin incorporation onto hydroxyapatite (HA) and Sr (SrHA)- and Zn (ZnHA)-substituted hydroxyapatite nanoparticles was investigated using X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectroscopy, zeta potential measurements and circular dichroism (CD) spectroscopy...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629082/influence-of-residual-composition-on-the-structure-and-properties-of-extracellular-matrix-derived-hydrogels
#20
Jesús A Claudio-Rizo, Magdalena Rangel-Argote, Laura E Castellano, Jorge Delgado, José L Mata-Mata, Birzabith Mendoza-Novelo
In this work, hydrolysates of extracellular matrix (hECM) were obtained from rat tail tendon (TR), bovine Achilles tendon (TAB), porcine small intestinal submucosa (SIS) and bovine pericardium (PB), and they were polymerized to generate ECM hydrogels. The composition of hECM was evaluated by quantifying the content of sulphated glycosaminoglycans (sGAG), fibronectin and laminin. The polymerization process, structure, physicochemical properties, in vitro degradation and biocompatibility were studied and related to their composition...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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