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Drug Testing and Analysis

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https://www.readbyqxmd.com/read/27886663/organic-impurity-profiling-of-methylone-and-intermediate-compounds-synthesized-from-catechol
#1
Erin Heather, Adam Bortz, Ronald Shimmon, Andrew M McDonagh
This work examined the synthesis and organic impurity profile of methylone prepared from catechol. The primary aim of this work was to determine whether the synthetic pathway used to prepare 3,4-methylenedioxypropiophenone could be ascertained through analysis of the synthesized methylone. The secondary aim was the structural elucidation and origin determination of the organic impurities detected in methylone and the intermediate compounds. The organic impurities present in the reaction products were identified using GC-MS and NMR spectroscopy...
November 25, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27885819/annual-banned-substance-review-analytical-approaches-in-human-sports-drug-testing
#2
Mario Thevis, Tiia Kuuranne, Hans Geyer, Wilhelm Schänzer
There has been an immense amount of visibility of doping issues on the international stage over the past 12 months and the complexity of doping controls has been reiterated on various occasions. Hence, analytical test methods continuously being updated, expanded, and improved to provide specific, sensitive, and comprehensive test results in line with the World Anti-Doping Agency's (WADA) 2016 Prohibited List represent one of several critical cornerstones of doping controls. This enterprise necessitates expediting the (combined) exploitation of newly generated information on novel and/or superior target analytes for sports drug testing assays, drug elimination profiles, alternative test matrices, and recent advances in instrumental developments...
November 25, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27860446/a-genetic-algorithm-based-framework-for-wavelength-selection-on-sample-categorization
#3
Michel J Anzanello, Gabrielli Yamashita, Marcelo Marcelo, Flavio F Fogliatto, Rafael S Ortiz, Kristiane Mariotti, Marco F Ferrão
In forensic and pharmaceutical scenarios, the application of chemometrics and optimization techniques have unveiled common and peculiar features of seized medicine and drug samples, helping investigative forces towards tracking illegal operations. This paper proposes a novel framework aimed at identifying relevant subsets of attenuated total reflectance Fourier transform infrared (ATR-FTIR) wavelengths for classifying samples into two classes, e.g. authentic or forged categories in case of medicines, or salt or base form in cocaine analysis...
November 18, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27860349/irms-to-study-a-common-cocaine-cutting-agent-phenacetin
#4
Virginie Ladroue, Laurence Dujourdy, Fabrice Besacier, Patrick Jame
Phenacetin is a pharmaceutical closely related to acetaminophen that has been banned in France for a long time due to its nephritic and carcinogenic adverse effects. It frequently appears in cocaine seizures as a cutting agent. Following both sanitary and intelligence motivations, this molecule was chosen for this study, and stable isotopes seemed to be the most appropriate tool. A total of 228 seized samples were collected over a six-year-long period, and 8 standards of known origin were purchased. They were submitted to GC or EA-IRMS measurements, depending on their complexity...
November 17, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27860443/purity-and-adulterant-analysis-of-some-recent-drug-seizures-in-italy
#5
Simona Pichini, Francesco Paolo Busardò, Adolfo Gregori, Paolo Berretta, Stefano Gentili, Roberta Pacifici
No abstract text is available yet for this article.
November 11, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27863142/identification-and-analytical-characterization-of-nine-synthetic-cathinone-derivatives-n-ethylhexedrone-4-cl-pentedrone-4-cl-%C3%AE-eapp-propylone-n-ethylnorpentylone-6-meo-bk-mdma-%C3%AE-pihp-4-cl-%C3%AE-php-and-4-f-%C3%AE-php
#6
Cuimei Liu, Wei Jia, Tao Li, Zhendong Hua, Zhenhua Qian
Clinical and forensic toxicology laboratories are continuously confronted by analytical challenges when dealing with the new psychoactive substances phenomenon. In this study, the analytical characterization of nine synthetic cathinones is described: 2-(ethylamino)-1-phenylhexan-1-one (N-ethylhexedrone 1), 1-(4-chlorophenyl)-2-(methylamino)pentan-1-one (4-Cl-pentedrone 2), 1-(4-chlorophenyl)-2-(ethylamino)pentan-1-one (4-Cl-α-EAPP 3), 1-(3,4-methylenedioxyphenyl)-2-propylaminopropan-1-one (propylone 4), 1-(3,4-methylenedioxyphenyl)-2-ethylaminopentan-1-one (N-ethylnorpentylone 5), 1-(6-methoxy-3,4-methylenedioxyphenyl)-2-methylaminopropan-1-one (6-MeO-bk-MDMA 6), 4-methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one (α-PiHP 7), 1-(4-chlorophenyl)-2-(pyrrolidin-1-yl)hexan-1-one (4-Cl-α-PHP 8), and 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl)hexan-1-one (4-F-α-PHP 9)...
November 9, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27863134/identification-and-physicochemical-characterization-of-4-fluorobutyrfentanyl-1-4-fluorophenyl-1-phenethylpiperidin-4-yl-amino-butan-1-one-4-fbf-in-seized-materials-and-the-postmortem-biological-samples
#7
Marcin Rojkiewicz, Milena Majchrzak, Rafał Celiński, Piotr Kuś, Mieczysław Sajewicz
In the course of the last decade, a substantial growth of new psychoactive substances (NPS) has been recorded. Within this group, a considerably fast growing sub-group is represented by the opioids, which are based on modifications of the fentanyl structure. In this study, identification and analytical characterization of a new fentanyl derivative, 4-fluorobutyrfentanyl (1-((4-fluorophenyl)(1-phenethylpiperidin-4-yl)amino)butan-1-one, 4-FBF), is described. Apart from the seized powder, 4-FBF was also identified in the e-cigarette liquid secured in Case 1...
November 9, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27863089/freeze-and-thaw-stability-and-long-term-stability-of-84-synthetic-cannabinoids-in-serum
#8
Cornelius Hess, Lynn Krueger, Michael Unger, Burkhard Madea
Information about stability of synthetic cannabinoids is important to give recommendations for storage conditions in cases in which use of synthetic cannabinoids is suspected. In this study freeze and thaw stability (3 cycles at -20 °C at 1.5 ng/ml) and long term stability at room temperature, 4 °C and -20 °C (until 150 days) were tested by a validated liquid chromatographic mass spectrometric method for 80 synthetic cannabinoids. Results demonstrated good freeze and thaw stability for most of the substances...
November 8, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27860448/applicability-of-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-for-cocaine-profiling
#9
Cuimei Liu, Zhendong Hua, Xin Meng
For the first time in China, the chemical profiling of cocaine specimens was performed at the National Narcotics Laboratory. An ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-QTOF-MS) method was developed and validated for simultaneous analysis of 14 cocaine alkaloids and 5 main adulterants. Among them, ecgonine methyl ester, ecgonine, benzoylecgonine, and norcocaine were identified by comparing with the standard materials; tropacocaine, 3,4,5-trimethoxycocaine, cis and trans cinnamoylcocaine were tentatively identified based on the exact masses of protonated molecules and product ions; six unidentified alkaloids of 182/1...
November 8, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27794182/targeted-analysis-of-116-drugs-in-hair-by-uhplc-ms-ms-and-its-application-to-forensic-cases
#10
Xin Wang, Sys Stybe Johansen, Marie Katrine Klose Nielsen, Kristian Linnet
A multi-target method that can detect a broad range of drugs of abuse in human hair, such as hypnotics, anxiolytics, analgesics, benzodiazepines, antihistamines, antidepressants, antipsychotics, and anticonvulsants, was developed based on ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The drugs were extracted from 10 mg of washed hair by incubation for 18 h in a 25:25:50 (v/v/v) mixture of methanol/acetonitrile/2 mM ammonium formate (8% acetonitrile, pH 5.3). For 51% of the basic drugs, the lower limits of quantification (LLOQs) were in the range of 0...
October 29, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27794181/preclinical-pharmacokinetics-and-adme-characterization-of-a-novel-anticancer-chalcone-cardamonin
#11
Swati Jaiswal, Mahendra Shukla, Abhisheak Sharma, Nagarjun Rangaraj, Kalpesh Vaghasiya, Mohd Yaseen Malik, Jawahar Lal
Cardamonin (CRD), a chalconoid obtained from several medicinal plants of Zingiberaceae family, had shown promising potential in cancer prevention and therapy. For further development and better pharmacological elucidation, we performed a series of in vitro and in vivo studies to characterize its preclinical pharmacokinetics. The study samples were analyzed using validated LC-MS/MS and HPLC-UV methods. CRD is partially soluble (<10 μM) and possess high permeability (>0.2 × 10-4 cm/sec). It is moderately bound to plasma proteins (<50%)...
October 28, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27787946/application-of-hbocs-electrophoretic-method-to-detect-a-new-blood-substitute-derived-from-the-giant-extracellular-hemoglobin-of-lugworm
#12
A Marchand, N Crepin, I Roulland, F Semence, V Domergue, F Zal, V Polard, A Coquerel
Manipulation of blood and blood components is prohibited in sports by the World Anti-Doping Agency (WADA). This includes the use of blood substitutes to increase oxygen transport, like hemoglobin-based oxygen carriers (HBOCs), which are compounds derived from hemoglobin. Despite their medical interest, the first generation of HBOCs had serious adverse effects and was abandoned. However, new studies are now exploiting the properties of marine worm hemoglobins, which circulate as giant extracellular complexes with high oxygen-binding capacities...
October 27, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27783890/reply-to-restolho-et-al-contactless-decontamination-of-hair-samples-cannabinoids
#13
LETTER
Bjoern Moosmann, Volker Auwärter
No abstract text is available yet for this article.
October 26, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27775857/dna-typing-for-personal-identification-of-urine-after-long-term-preservation-for-testing-in-doping-control
#14
Kimiko Aoki, Hiroyuki Tanaka, Makoto Ueki
When the tampering of a urine sample is suspected in doping control, personal identification of the sample needs to be determined by short tandem repeat (STR) analysis using DNA. We established a method for extracting DNA from urine samples stored at -20 °C without using any additives or procedures, which is consistent with how samples are required to be managed for doping control. The method, using the Puregene® Blood Core kit followed by NucleoSpin® gDNA Clean-up or NucleoSpin® gDNA Clean-up XS kit, does not need any special instrument and can provide a purified extract with high-quality DNA from up to 40 mL of urine suitable for STR analysis using an AmpFlSTR® Identifiler® PCR amplification kit...
October 24, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27770510/isomeric-discrimination-of-synthetic-cannabinoids-by-gc-ei-ms-1-adamantyl-and-2-adamantyl-isomers-of-n-adamantyl-carboxamides
#15
Akiko Asada, Takahiro Doi, Takaomi Tagami, Akihiro Takeda, Yoshiyuki Sawabe
N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA) and N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) are carboxamide-type synthetic cannabinoids comprising indazole/indole-3-carboxylic acid and adamantan-1-amine moieties. However, in the case of compounds like APINACA or APICA, adamantyl positional isomers exist, wherein either adamantan-1-amine or adamantan-2-amine is present. These adamantyl positional isomers have not been reported in previous studies, and no analytical data are available yet...
October 21, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27764538/comparative-evaluation-of-chemical-profiles-of-three-representative-snow-lotus-herbs-by-uplc-dad-qtof-ms-combined-with-principal-component-and-hierarchical-cluster-analyses
#16
Qi-Lei Chen, Lin Zhu, Yi-Na Tang, Hiu-Yee Kwan, Zhong-Zhen Zhao, Hu-Biao Chen, Tao Yi
Herbal healthcare products are used worldwide as relatively safe and effective alternatives to allopathic drugs. Saussurea laniceps Hand.-Mazz.(SL), S. medusa Maxim. (SM) and S. involucrata (Kar. et Kir.) Sch.Bip. (SI) are three sources of the renowned "snow lotus" Chinese Materia Medica for treating inflammatory diseases. The three species have different therapeutic effects, among which SL has been proved to be the most potent, but they are frequently confused on the market and in the academic community. An ultra-high performance liquid chromatography-diode array detector-quadrupole time of flight-mass spectrometry (UPLC-DAD-QTOF-MS) method was developed and used to analyze 49 herbal samples for species analysis and overall quality evaluation...
October 20, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27758048/urinary-steroid-profile-in-females-the-impact-of-menstrual-cycle-and-emergency-contraceptives
#17
Jenny E Mullen, John-Olof Thörngren, Jenny J Schulze, Magnus Ericsson, Nina Gårevik, Mikael Lehtihet, Lena Ekström
Today's doping tests involving longitudinal monitoring of steroid profiles are difficult in women. Women have more complex hormonal fluctuations than men and commonly take drugs such as hormonal contraceptives that are shown to affect biomarkers used in these doping tests. In this study we followed six women's urinary steroid profile during one menstrual cycle, including both glucuronides and sulfate conjugated fractions. Additionally, we studied what happens to the steroidal module of the athlete biological passport (ABP) after administration of an emergency contraceptive (levonorgestrel, NorLevo®)...
October 18, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27758046/hepcidin-as-a-potential-biomarker-for-blood-doping
#18
Nicolas Leuenberger, Emanuele Bulla, Olivier Salamin, Raul Nicoli, Neil Robinson, Norbert Baume, Martial Saugy
The concentration of hepcidin, a key regulator of iron metabolism, is suppressed during periods of increased erythropoietic activity. The present study obtained blood samples from 109 elite athletes and examined the correlations between hepcidin and markers of erythropoiesis and iron metabolism (i.e., hemoglobin, erythropoietin (EPO), ferritin, erythroferrone (ERFE), and iron concentration). Furthermore, an administration study was undertaken to examine the effect of recombinant human EPO (rhEPO) delta (Dynepo™) on hepcidin concentrations in healthy male volunteers...
October 18, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27750404/targeted-and-non-targeted-drug-screening-in-whole-blood-by-uhplc-tof-ms-with-data-independent-acquisition
#19
Christian Brinch Mollerup, Petur Weihe Dalsgaard, Marie Mardal, Kristian Linnet
High-resolution mass spectrometry (HRMS) is widely used for the drug screening of biological samples in clinical and forensic laboratories. With the continuous addition of new psychoactive substances (NPS), keeping such methods updated is challenging. HRMS allows for combined targeted and non-targeted screening; first, peaks are identified by software algorithms, and identifications are based on reference standard data. Remaining unknown peaks are attempted identified with in silico and literature data. However, several thousand peaks remain where most are unidentifiable or uninteresting in drug screening...
October 17, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27736030/studies-on-the-metabolism-of-the-fentanyl-derived-designer-drug-butyrfentanyl-in-human-in-vitro-liver-preparations-and-authentic-human-samples-using-liquid-chromatography-high-resolution-mass-spectrometry-lc-hrms
#20
Andrea E Steuer, Elena Williner, Sandra N Staeheli, Thomas Kraemer
Increasing numbers of new psychoactive substances (NPS) among them fentanyl derivatives has been reported by the European monitoring centre for drugs and drug addiction (EMCDDA). Butyrfentanyl is a new fentanyl derivative whose potency ratio was found to be seven compared to morphine and 0.13 compared to fentanyl. Several case reports on butyrfentanyl intoxications have been described. Little is known about its pharmacokinetic properties including its metabolism. However, knowledge of metabolism is essential for analytical detection in clinical and forensic toxicology...
October 13, 2016: Drug Testing and Analysis
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