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Drug Testing and Analysis

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https://www.readbyqxmd.com/read/28643437/silibinin-affects-the-pharmacokinetics-of-methadone-in-rats
#1
Pei-Pei Pan, Jun Wang, Jun Luo, Shuang-Hu Wang, Yun-Fang Zhou, Sai-Zhen Chen, Zhou Du
The aim of the present study was to investigate the pharmacokinetic effect of silibinin on methadone in rats. 24 male Sprague-Dawley rats were randomly divided into 4 groups: control group, single dose of 100 mg/kg group, multiple doses of 100 mg/kg group and multiple doses of 30 mg/kg group. A single dose of 6 mg/kg methadone was administrated to rats orally without or with silibinin. Plasma samples were collected via tail vein at different time points and concentrations of methadone and its metabolite, EDDP, were determined by UPLC-MS/MS...
June 22, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28643431/a-study-of-the-origin-of-chloramphenicol-isomers-in-honey
#2
Dmytro Yanovych, Bjorn Berendsen, Zvenyslava Zasadna, Mariana Rydchuk, Tobias Czymai
Due to the unexpected detection of chloramphenicol isomer residues in honey, we have studied the hypothesis of unauthorized or unintended use of unregistered veterinary drug preparations. First we have investigated honey samples in which a discrepancy was observed between the results of the immunological screening methods and the confirmatory LC-MS/MS method. In all samples, previously identified to be contaminated with the banned antibiotic chloramphenicol according to LC-MS/MS only, the presence of dextramycin (SS-para isomer of chloramphenicol) was detected by chiral LC-MS/MS...
June 22, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28640970/prevalence-of-new-psychoactive-substances-and-prescription-drugs-in-the-belgian-driving-under-the-influence-of-drugs-population
#3
S M R Wille, C Richeval, M Nachon-Phanithavong, J M Gaulier, V Di Fazio, L Humbert, N Samyn, D Allorge
Driving under the influence of drugs (DUID) is a worldwide problem. Several countries adopted DUID legislations which prove their deterrent effect and impact on road safety. However, use of new psychoactive substances (NPS) and prescription drugs is not known as the applied roadside screening tests are not yet adapted for these compounds. In this study, 558 blood samples obtained during roadside controls in Belgium (January to August 2015) after a positive Drugwipe 5S® test and 199 oral fluid (OF) samples obtained from negatively screened test pads were analyzed...
June 22, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28635171/replacing-paps-in-vitro-phase-ii-sulfation-of-steroids-with-the-liver-s9-fraction-employing-atp-and-sodium-sulfate
#4
Sumudu A Weththasinghe, Christopher C Waller, Han Ling Fam, Bradley J Stevenson, Adam T Cawley, Malcolm D McLeod
In vitro technologies provide the capacity to study drug metabolism where in vivo studies are precluded due to ethical or financial constraints. The metabolites generated by in vitro studies can assist anti-doping laboratories to develop protocols for the detection of novel substances that would otherwise evade routine screening efforts. In addition, professional bodies such as the Association of Official Racing Chemists (AORC) currently permit the use of in vitro derived reference materials for confirmation purposes providing additional impetus for the development of cost effective in vitro metabolism platforms...
June 21, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28635164/assessing-the-toxicological-significance-of-new-psychoactive-substances-in-fatalities
#5
Simon Elliott, Roumen Sedefov, Michael Evans-Brown
No abstract text is available yet for this article.
June 21, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28631881/advances-in-equine-anti-doping
#6
EDITORIAL
Adam Cawley
No abstract text is available yet for this article.
June 20, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28608586/metabolism-of-novel-opioid-agonists-u-47700-and-u-49900-using-human-liver-microsomes-with-confirmation-in-authentic-urine-specimens-from-drug-users
#7
Alex J Krotulski, Amanda L A Mohr, Donna M Papsun, Barry K Logan
Recently, the number of adverse events, including death, involving novel opioids has continued to increase, providing additional and sustained challenges for forensic and medical communities. Identification of emerging novel opioids can be challenging, compounded by detection windows and unknown metabolic profiles. In this study, human liver microsomes were used for the generation of in vitro metabolic profiles of U-47700 and U-49900. Generated metabolites were analyzed via a SCIEX TripleTOF® 5600+ quadrupole time-of-flight mass spectrometer and resulting data files were processing using MetabolitePilot™...
June 13, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28600878/non-targeted-acquisition-strategy-for-screening-doping-compounds-based-on-gc-ei-hybrid-quadrupole-orbitrap-mass-spectrometry-focus-on-exogenous-anabolic-steroids
#8
Gustavo de Albuquerque Cavalcanti, Lucas Martins Rodrigues, Leonardo Dos Santos, Xin Zheng, Amit Gujar, Jason Cole, Monica Costa Padilha, Francisco Radler de Aquino Neto
This is a first look at a non-targeted screening method based on Orbitrap GC/MS technology for a large number of banned compounds in sports found in urine, including: exogenous anabolic steroids, β-agonists, narcotics, stimulants, hormone modulators, and diuretics. A simple sample preparation was processed in four steps: an enzymatic hydrolysis, liquid-liquid extraction, evaporation and trimethylsilylation. All compounds were able to meet WADA's sensitivity criteria with mass accuracies less than 1 ppm and with sufficient points across the peak by running the Orbitrap GC/MS in full scan mode...
June 10, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28600832/investigation-of-drug-products-received-for-analysis-in-the-swedish-strida-project-on-new-psychoactive-substances
#9
Matilda Bäckberg, Karl-Henrik Jönsson, Anders Helander, Olof Beck
The web-based open sale of unregulated new psychoactive substances (NPS) has shown a steady increase over the past years. Analysis of drug products sold as NPS is useful to confirm the true chemical contents, for comparison with the substances detected in corresponding body fluids, but also to study drug trends. This work describes the examination of 251 drug products that were randomly submitted for analysis in 173 cases of suspected NPS-related intoxications in the Swedish STRIDA project in 2010-2015. Of the products, 39% were powders/crystals, 32% tablets/capsules, 16% herbal materials, 8% liquids, 1% blotters, and 4% others...
June 9, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28585411/ultra-fast-lc-ms-ms-in-therapeutic-drug-monitoring-quantification-of-clozapine-and-norclozapine-in-human-plasma
#10
Lewis Couchman, Danielle S Fisher, Krithika Subramaniam, Simon A Handley, Robert J Boughtflower, Christopher M Benton, Robert J Flanagan
A novel approach to high-throughput, targeted LC-MS/MS analysis has been developed. A single chromatographic system can be used for the analysis of a range of 20 drugs and metabolites with a total analysis time of 36 seconds (one 96-well plate of prepared samples per hour). To demonstrate the applicability of this approach to quantitative analysis, a method has been validated for the therapeutic drug monitoring of clozapine and norclozapine following automated extraction from human plasma. Chromatographic retention times were 11...
June 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28585392/return-of-the-lysergamides-part-iv-analytical-and-pharmacological-characterization-of-lysergic-acid-morpholide-lsm-775
#11
Simon D Brandt, Pierce V Kavanagh, Brendan Twamley, Folker Westphal, Simon P Elliott, Jason Wallach, Alexander Stratford, Landon M Klein, John D McCorvy, David E Nichols, Adam L Halberstadt
Lysergic acid diethylamide (LSD) is perhaps one of the best-known psychoactive substances and many structural modifications of this prototypical lysergamide have been investigated. Several lysergamides were recently encountered as "research chemicals" or new psychoactive substances (NPS). Although lysergic acid morpholide (LSM-775) appeared on the NPS market in 2013, there is disagreement in the literature regarding the potency and psychoactive properties of LSM-775 in humans. The present investigation attempts to address the gap of information that exists regarding the analytical profile and pharmacological effects of LSM-775...
June 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28570781/the-effect-of-antioxidants-on-the-long-term-stability-of-thc-and-related-cannabinoids-in-sampled-whole-blood
#12
Lambert K Sørensen, Jørgen B Hasselstrøm
The stability of cannabinoids is complex, and crucial for the assessment of impaired driving caused by cannabis. Therefore, the effect of antioxidants on the long-term stability of Δ(9) -tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-hydroxy-Δ(9) -tetrahydrocannabinol (THC-OH) and 11-nor-9-carboxy-Δ(9) -tetrahydrocannabinol (THC-COOH) in whole blood samples preserved with fluoride citrate (FC) and fluoride oxalate (FX) mixtures was investigated at different temperatures. The measured concentrations of the cannabinoids in authentic whole blood preserved solely with FC or FX mixtures decreased significantly during prolonged storage at -20°C...
June 1, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28560823/identification-and-quantification-of-predominant-metabolites-of-synthetic-cannabinoid-mab-chminaca-in-an-authentic-human-urine-specimen
#13
Koutaro Hasegawa, Kayoko Minakata, Kunio Gonmori, Hideki Nozawa, Itaru Yamagishi, Kanako Watanabe, Osamu Suzuki
An autopsy case in which the cause of death was judged as drug poisoning by two synthetic cannabinoids, including MAB-CHMINACA, was experienced. Although unchanged MAB-CHMINACA could be detected from solid tissues, blood and stomach contents in the case, the compound could not be detected from the urine specimen. In this article, we obtained six kinds of reference standards of MAB-CHMINACA metabolites from a commercial source. The MAB-CHMINACA metabolites from the urine specimen of the abuser were extracted by a QuEChERS method including dispersive solid-phase extraction, and analyzed by liquid chromatography-tandem mass spectrometry with or without hydrolysis with β-glucuronidase...
May 30, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28548390/a-step-towards-removing-plasma-volume-variance-from-the-athlete-s-biological-passport-the-use-of-biomarkers-to-describe-vascular-volumes-from-a-simple-blood-test
#14
Louisa M Lobigs, Pierre-Edouard Sottas, Pitre C Bourdon, Zoran Nikolovski, Mohamed El-Gingo, Evdokia Varamenti, Peter Peeling, Brian Dawson, Yorck O Schumacher
The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration-based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma volume (PV). Fluctuations in PV contribute to the majority of biological variance associated with volumetric ABP markers. Our laboratory recently identified a panel of common chemistry markers (from a simple blood test) capable of describing ~67% of PV variance, presenting an applicable method to account for volume shifts within antidoping practices...
May 26, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28544816/analytical-characterization-of-three-cathinone-derivatives-4-mpd-4%C3%A2-f-php-and-bk-epdp-purchased-as-bulk-powder-from-online-vendors
#15
Orapan Apirakkan, Anca Frinculescu, Trevor Shine, Mark C Parkin, Agostino Cilibrizzi, Nunzianda Frascione, Vincenzo Abbate
Novel emerging drugs of abuse, also referred as new psychoactive substances (NPS), constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical modifications of previously banned recreational drugs. One of such class, synthetic cathinones, namely β-keto derivatives of amphetamines, has been largely abused over the past decade. A number of new synthetic cathinones are detected each year, either in bulk powders/crystals or in biological matrices. It is therefore important to continuously monitor the supply of new synthetic derivatives and promptly report them...
May 23, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28544602/drug-residues-in-syringes-and-other-injecting-paraphernalia-in-hungary
#16
Anna Péterfi, József Csorba, Tamás Figeczki, József Kiss, Katalin Medgyesi-Frank, János Posta, V Anna Gyarmathy
The appearance and spread of new psychoactive substances (NPS) is a phenomenon detected throughout Europe since 2008. Synthetic cathinones, a group of NPS, have been self-reported as the drug injected by the vast majority of people who inject drugs (PWID) in Hungary. This study aims at updating our knowledge on what exactly the compounds injected by PWID. This multi-site study analysed residues from used injecting drug paraphernalia collected from PWID via low threshold services and from public places in Budapest, Debrecen, Miskolc, Szeged, Békéscsaba and Pécs between March 2015 and February 2016...
May 23, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28544440/purity-and-adulteration-in-cocaine-seizures-and-drug-market-inspection-in-galicia-spain-across-an-eight-year-period
#17
LETTER
Mª de Los Ángeles Villar Núñez, José Sánchez Morcillo, María Adolfina Ruíz Martínez
No abstract text is available yet for this article.
May 23, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28544560/fatal-intoxication-by-5f-adb-and-diphenidine-detection-quantification-and-investigation-of-their-main-metabolic-pathways-in-human-by-lc-ms-ms-and-lc-q-tofms
#18
Maiko Kusano, Kei Zaitsua, Kentaro Taki, Kazuaki Hisatsune, Jun'ichi Nakajima, Takako Moriyasu, Tomomi Asano, Yumi Hayashi, Hitoshi Tsuchihashi, Akira Ishii
Despite the implementation of the new blanket scheduling system in 2013, new psychoactive substance (NPS) abuse remains a serious social concern in Japan. We present a fatal intoxication case involving 5F-ADB (methyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate) and diphenidine. Postmortem blood screening by liquid chromatography/quadrupole time-of-flight mass spectrometry (LC/Q-TOFMS) in the information dependent acquisition (IDA) mode only detected diphenidine. Further urinary screening using an in-house database containing new NPS and metabolites detected not only diphenidine but also possible 5F-ADB metabolites; subsequent targeted screening by LC/tandem mass spectrometry (LC/MS/MS) allowed for the detection of very low level of unchanged 5F-ADB in postmortem heart blood...
May 21, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28513099/syntheses-analytical-and-pharmacological-characterizations-of-the-legal-high-4-1-3-methoxyphenyl-cyclohexyl-morpholine-3-meo-pcmo-and-analogues
#19
Tristan Colestock, Jason Wallach, Matt Mansi, Nadine Filemban, Hamilton Morris, Simon P Elliott, Folker Westphal, Simon D Brandt, Adeboye Adejare
New psychoactive substances (NPS) are commonly referred to as "research chemicals", "designer drugs" or "legal highs." One NPS class is represented by dissociative anesthetics, which include analogues of the arylcyclohexylamine phencyclidine (PCP), ketamine, and diphenidine. A recent addition to the NPS market was 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine (3-MeO-PCMo), a morpholine analogue of 3-MeO-PCP. Although suspected to have dissociative effects in users, information about its pharmacological profile is not available...
May 16, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28513092/pharmacokinetics-and-pharmacodynamics-of-meldonium-in-exercised-thoroughbred-horses
#20
Heather K Knych, Scott D Stanley, Dan S McKemie, Rick M Arthur, Ulf Bondesson, Mikael Hedeland, Mario Thevis, Philip H Kass
Although developed as a therapeutic medication, meldonium has found widespread use in human sports and was recently added to the World Anti-Doping Agency's list of prohibited substances. It's reported abuse potential in human sports, has led to concern by regulatory authorities about the possible misuse of meldonium in equine athletics. The potential abuse in equine athletes along with the limited data available regarding the pharmacokinetics and pharmacodynamics of meldonium in horses necessitates further study...
May 16, 2017: Drug Testing and Analysis
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