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Drug Testing and Analysis

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https://www.readbyqxmd.com/read/28815945/development-of-a-quantitative-method-for-the-analysis-of-cocaine-analogue-impregnated-into-textiles-by-raman-spectroscopy
#1
Linda Xiao, Rhiannon Alder, Megha Mehta, Nadine Krayem, Bianca Cavasinni, Sean Laracy, Shane Cameron, Shanlin Fu
Cocaine trafficking in the form of textile impregnation is routinely encountered as a concealment method. Raman spectroscopy has been a popular and successful testing method used for in situ screening of cocaine in textiles and other matrices. Quantitative analysis of cocaine in these matrices using Raman spectroscopy has not been reported to date. This study aimed to develop a simple Raman method for quantifying cocaine using atropine as the model analogue in various types of textiles. Textiles were impregnated with solutions of atropine in methanol...
August 16, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28809091/different-localizations-of-drugs-simultaneously-administered-in-a-strand-of-hair-by-micro-segmental-analysis
#2
Kenji Kuwayama, Hajime Miyaguchi, Yuko T Iwata, Tatsuyuki Kanamori, Kenji Tsujikawa, Tadashi Yamamuro, Hiroki Segawa, Hiroyuki Inoue
Segmental hair analysis is used to estimate the time of drug intake at monthly precision in drug-related crimes. Previously we advanced this analytical method to specify the day of drug intake by cutting a strand of hair into 0.4-mm segments, which correspond to daily hair growth. Herein, we investigated the distributions of seven compounds in a strand of hair using micro-segmental analysis. Several strands of hair were collected 33.1-229.4 days after subjects were administered four pharmaceutical products that contained 10 drugs in single doses within 32 h...
August 15, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28809088/the-analysis-of-illicit-25x-nbome-seizures-in-western-australia
#3
LETTER
Rohan Edmunds, Richard Donovan, Dominic Reynolds
The NBOMe class of compounds have gained prominence in recent years in the illicit drug scene and are marketed as an alternative to LSD, or in some cases sold under the pretense of being LSD. Publications reporting the identification of a novel NBOMe compound are common however, there is no scientific data reporting the amounts of these compounds found in seizures that have been submitted to forensic science laboratories for analysis. This publication reports the quantitation of three different NBOMe compounds, 25C-NBOMe, 25I-NBOMe and 25B-NBOMe in seizures by Western Australia Police of blotter papers and tablets...
August 15, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28801989/determination-of-higenamine-and-coclaurine-levels-in-human-urine-after-the-administration-of-a-throat-lozenge-containing-nandina-domestica-fruit
#4
Masato Okano, Mitsuhiko Sato, Shinji Kageyama
Higenamine is a key component of traditional Chinese herbal medicine. The fruit of Nandina domestica (which contains this component) is available as an ingredient in the so-called Nanten-nodo-ame throat lozenge found on the Japanese market, which is an over-the-counter pharmaceutical and is easy to purchase for Japanese athletes. However, higenamine is a non-selective β2-agonist, which is exemplified in the prohibited list of the World Anti-Doping Agency (WADA). Therefore, some have raised a concern regarding the potential cause of increased unintentional higenamine doping cases in the Asian region...
August 12, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28777889/strategies-of-gnrh-synthetic-analogues-determination-in-doping-control-in-vitro-and-in-vivo-metabolism-data-evaluation-of-lh-and-steroid-profile-parameters-fluctuations-as-suitable-biomarkers
#5
Irina Zvereva, Grigory Dudko, Marina Dikunets
Gonadotropin-releasing hormone (GnRH) and its small peptide synthetic analogues included at Section S2 of World Anti-Doping Agency (WADA) Prohibited List as they stimulate pituitary LH and testicular testosterone (T) secretion. Both following approaches can be applied for determination of these peptides abuse: direct identification of intact compounds and their metabolites in athletes' biofluids along with evaluation of LH and T concentrations as mediate markers of drug intake. To develop an effective concept for GnRH and its analogues determination in anti-doping control in vitro and in vivo studies were conducted...
August 4, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28777878/a-multi-analyte-approach-to-help-in-assessing-the-severity-of-acute-poisonings-development-and-validation-of-a-fast-lc-ms-ms-quantification-approach-for-45-drugs-and-relevant-metabolites-with-one-point-calibration
#6
Julian A Michely, Hans H Maurer
In emergency toxicology, diagnosis, monitoring of the efficiency of detoxification, and estimating the prognosis of acute poisonings are important tasks. Comprehensive screening and quantification of relevant substances by gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS) help in assessing the severity of most acute poisonings. Turnaround time for such analyses must be short enough for having impact on clinical decisions. Therefore, a multi-analyte LC-MS/MS approach with a 5-min gradient was developed and validated for 45 drugs and active metabolites as complement to an existing GC-MS approach using the same liquid-liquid extraction...
August 4, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28758363/validation-of-an-lc-ms-ms-method-for-analysis-of-anti-diabetic-drugs-in-botanical-dietary-supplements-labelled-for-blood-sugar-management
#7
Jun Ma, Rahul S Pawar, Erich Grundel
We developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to detect and quantitate 14 anti-diabetic, 2 anti-obesity and 3 cholesterol-lowering drugs in botanical dietary supplements marketed for blood sugar management. Many botanical dietary supplements which carry label statements related to blood sugar management are available over the internet. Potential adulteration of such dietary supplements with anti-diabetic and other prescription drugs, some of which have been removed from the market due to adverse events, is of concern...
July 31, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28755512/power-of-orbitrap-based-lc-high-resolution-ms-ms-for-comprehensive-drug-testing-in-urine-with-or-without-conjugate-cleavage-or-using-dried-urine-spots-after-on-spot-cleavage-in-comparison-to-established-lc-ms-n-or-gc-ms-procedures
#8
Julian A Michely, Markus R Meyer, Hans H Maurer
Reliable, sensitive, and comprehensive urine screening procedures by GC-MS or LC-MS with low or high resolution (HR) are of high importance for drug testing, adherence monitoring, or detection of toxic compounds. Besides conventional urine sampling, dried urine spots are of increasing interest. In the present study, the power of LC-HR-MS/MS was investigated for comprehensive drug testing in urine with or without conjugate cleavage or using dried urine spots after on-spot cleavage in comparison to established LC-MS(n) or GC-MS procedures...
July 29, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28753737/uplc-ms-ms-method-for-therapeutic-drug-monitoring-of-ten-antibiotics-used-in-intensive-care-units
#9
Nahed El-Najjar, Julian Hösl, Thomas Holzmann, Jonathan Jantsch, André Gessner
Large variation in the levels of different ß-lactams and other antibiotics used in critically ill patients has been documented. The aim of this study is to establish and validate a fast ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous analysis of ten antibiotics (Meropenem, Cefepime, Ceftazidime, Piperacillin, Benzylpenicillin, Ampicillin, Flucloxacillin, Linezolid, and Sulfamethoxazole/Trimethoprim) in human plasma according to European Medicines Agency (EMA) guidelines...
July 28, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28743169/development-and-validation-of-an-optical-biosensor-for-rapid-monitoring-of-adalimumab-in-serum-of-patients-with-crohn-s-disease
#10
Sumin Bian, Jiadi Lu, Filip Delport, Séverine Vermeire, Dragana Spasic, Jeroen Lammertyn, Ann Gils
Therapeutic drug monitoring of adalimumab is recommended to improve therapeutic outcome in patients with Crohn's disease. Performing an ELISA requires a rather long time-to-result and the necessity of collecting multiple samples in order to decrease the cost per adalimumab determination. In this study, we aim to develop and validate a rapid assay suitable for measuring a single adalimumab serum sample using a fiber-optic surface plasmon resonance (FO-SPR) based sensor. Therefore, we have immobilized MA-ADM28B8 as capture antibody on a FO-probe and conjugated MA-ADM40D8 as detecting antibody to gold nanoparticles...
July 25, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28731573/effect-of-alcohol-dehydrogenase-1b-and-7-polymorphisms-on-blood-ethanol-and-acetaldehyde-concentrations-in-healthy-subjects-with-a-history-of-moderate-alcohol-consumption
#11
Roberta Pastorino, Luigi Iuliano, Alessia Vecchioni, Dario Arzani, Mirta Milic, Francesca Annunziata, Chiara Zerbinati, Ettore Capoluongo, Stefano Bonassi, James D McKay, Stefania Boccia
AIMS: To evaluate the effect of ADH1B and ADH7 genotypes on blood acetaldehyde and ethanol levels after alcohol ingestion, and to measure the genotoxic effect of smoking and ethanol on the buccal cells, also controlling for ADH variants. METHODS: We recruited healthy Italian subjects with at least a moderate history of alcohol consumption. All subjects were given an alcoholic drink of 0.4 g ethanol /kg of body weight. Blood venous samples were collected at baseline, and 30, 60, 90 and 120 minutes after ingestion...
July 21, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28730714/alkaloid-profiling-of-herbal-drugs-using-high-resolution-mass-spectrometry
#12
Tiziana Nardin, Edi Piasentier, Chiara Barnaba, Roberto Larcher
Herbal infusions are consumed worldwide thanks to their "natural" beneficial effects, also due to the presence of alkaloids, although these compounds can have poisonous effects. A method combining online solid-phase purification with high resolution mass spectrometry was used to define the alkaloid profiles of 117 herbs and 7 commercial blends. 41 alkaloids were quantified in reference to analytical standards, while the presence of a further 116 was confirmed on the basis of accurate mass, retention time and fragmentation profile...
July 21, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28719153/in-source-collision-induced-dissociation-is-cid-applications-issues-and-structure-elucidation-with-single-stage-mass-analyzers
#13
Jon F Parcher, Mei Wang, Amar G Chittiboyina, Ikhlas A Khan
A discussion of the definition, advantages and issues with the formation of ions in the transition region between an ESI source and the ion optics of a mass analyzer is presented. The various types of ions formed in the so-called in-source collision induced dissociation (IS-CID) process are illustrated. Applications of IS-CID with single-stage mass analyzers, such as structure elucidation and quantitation, are demonstrated. The discussion is illustrated by examples of the in-source fragmentation of ginkgolides, which are marker compounds found only in Ginkgo biloba...
July 18, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28691766/detection-of-metabolites-of-the-new-synthetic-cannabinoid-cumyl-4cn-binaca-in-authentic-urine-samples-and-human-liver-microsomes-using-high-resolution-mass-spectrometry
#14
Yeter Erol Ozturk, Oya Yeter, Serkan Ozturk, Goksun Karakus, Ismail Ates, Yalçın Buyuk, Turkan Yurdun
CUMYL-4CN-BINACA(1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide) is a recently introduced indazole-3-carboxamide type synthetic cannabinoid (SC) that was detected in herbal incense seized by of the Council of Forensic Medicine Istanbul Narcotics Department in May 2016 in Turkey. Recently introduced SCs are not detected in routine toxicological analysis; therefore, analytical methods to measure these compounds are in demand. The present study aims to identify urinary marker metabolites of CUMYL-4CN-BINACA by investigating its metabolism in human liver microsomes and to confirm the results in authentic urine samples (n=80)...
July 10, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28688175/discrimination-between-closely-related-synthetic-cannabinoids-by-gc-cold-ei-ms
#15
Evgeny Smolianitski-Fabian, Etia Cohen, Marina Dronova, Anna Voloshenko-Rossin, Ovadia Lev
Gas chromatography thermal-electron ionization mass spectrometry (GC-EI-MS) is an established method for the identification of mind-altering substances and is routinely used by forensic laboratories. However, some commonly analyzed drugs of abuse, relating to the synthetic cannabinoids receptor agonist group (SCs), pose a challenge for this conventional technique. As the molecular cation radicals of many excited SCs are labile within the ion source, the relative abundance of the molecular ions obtained by the GC-EI-MS is often too small to allow discrimination of structurally related drugs...
July 8, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28688172/potential-impact-of-the-sewer-system-on-the-applicability-of-alcohol-and-tobacco-biomarkers-in-wastewater-based-epidemiology
#16
Andrew P W Banks, Foon Yin Lai, Jochen F Mueller, Guangming Jiang, Steve Carter, Phong K Thai
Understanding the actual consumption of alcohol and tobacco in the population is important for forming public health policy. For this purpose, wastewater-based epidemiology has been applied as a complementary method to estimate the overall alcohol and tobacco consumption in different communities. However, the stability of their consumption biomarkers, ethyl sulfate, ethyl glucuronide, cotinine and trans-3'-hydroxycotinine, in the sewer system has not yet been assessed. This study aimed to conduct such assessment using sewer reactors mimicking conditions of rising main, gravity sewer and wastewater alone, over a 12-hour period...
July 8, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28681463/confirmation-of-recent-heroin-abuse-accepting-the-challenge
#17
REVIEW
Alexandra Maas, Burkhard Madea, Cornelius Hess
Confirmation or exclusion of recent heroin consumption is still one of the major challenges for forensic and clinical toxicologists. A great variety of biomarkers is available for heroin abuse confirmation, including various opium alkaloids (e.g. morphine, codeine), street heroin impurities (e.g. 6-acetylcodeine (6-AC), noscapine, papaverine) as well as associated metabolites (e.g. 6-monoacetylmorphine (6-MAM), morphine glucuronides). Though, the presence of most of these biomarkers cannot solely be attributed to a previous heroin administration but can, among other things, also be due to consumption of poppy seed products ('poppy seed defense'), opium preparations or specific medications, respectively...
July 6, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28677880/study-of-the-in-vitro-and-in-vivo-metabolism-of-the-tryptamine-5-meo-mipt-using-human-liver-microsomes-and-real-case-samples
#18
Katharina Elisabeth Grafinger, Marianne Hädener, Stefan König, Wolfgang Weinmann
The synthetic tryptamine 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) has recently been abused as a hallucinogenic drug in Germany and Switzerland. This study presents a case of 5-MeO-MiPT intoxication and the structural elucidation of metabolites in pooled human liver microsomes (pHLM), blood, and urine. Microsomal incubation experiments were performed using pHLM to detect and identify in vitro metabolites. In August 2016, the police encountered a naked man, agitated and with aggressive behavior on the street...
July 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28677876/human-urinary-metabolic-patterns-of-the-designer-benzodiazepines-flubromazolam-and-pyrazolam-studied-by-liquid-chromatography-high-resolution-mass-spectrometry
#19
Madeleine Pettersson Bergstrand, Markus R Meyer, Olof Beck, Anders Helander
Over the past ~8 years, hundreds of unregulated new psychoactive substances (NPS) of various chemical categories have been introduced as recreational drugs through mainly open online trade. This study was performed to further investigate the human metabolic pattern of the NPS, or designer benzodiazepines flubromazolam and pyrazolam, and to propose analytical targets for urine drug testing of these substances. The urine samples originated from patient samples confirmed by liquid chromatography-high-resolution tandem mass spectrometry (LC-HRMS/MS) analysis to contain flubromazolam or pyrazolam...
July 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28671321/the-influence-of-small-doses-of-ethanol-on-the-urinary-testosterone-to-epitestosterone-ratio-in-men-and-women
#20
Sami Albeiroti, Brian D Ahrens, Timofei Sobolevskii, Anthony W Butch
Endogenous steroid use can increase urinary testosterone/epitestosterone (T/E) values. In addition, ethanol in amounts >0.5 g per kg of body weight (g/kg) can also increase T/E values. However, the effect of smaller doses of ethanol on T/E values is unknown. The influence of 0.2 and 0.4 g/kg of ethanol on baseline T/E values in 20 men and 20 women with low and high baseline T/E values was investigated and correlated with ethyl glucuronide (EtG) and ethyl sulfate (EtS) concentrations. T/E values for 7 of the women were excluded from the study because of undetectable T concentrations or for other reasons...
July 3, 2017: Drug Testing and Analysis
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