Rui-Jia Chen, Zi-Hua Zhang, Shenglan Yang, Shu-Chen Yu, Jun-Chang Wang, Ping-Yong Liao, Ting-Ting Qiu, Lu Xiao, Shang Xue, Hong Chen, Wen-Bin Shao, Jian-Wen Hu, Yun Lan, Xi-Long Chen, Yue Xu, Tian-Meng Zhou, Xue-Jun Zhao, Wen-Bin Liu
5F-MDMB-PICA, an indole-type synthetic cannabinoid (SC), was classified illicit globally in 2020. Although the extensive metabolism of 5F-MDMB-PICA in the human body warrants the development of robust analytical methods for metabolite detection and quantification, a current lack of reference standards for characteristic metabolites hinders such method creation. This work described the synthesis of 18 reference standards for 5F-MDMB-PICA and its possible Phase I metabolites, including three hydroxylated positional isomers R14 to R16...
March 15, 2024: Drug Testing and Analysis