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Journal of Gynecologic Oncology

Joo Hyuk Son, Suk Joon Chang, Hee Sug Ryu
No abstract text is available yet for this article.
November 2018: Journal of Gynecologic Oncology
Stefano Uccella, Francesca Falcone, Stefano Greggi, Francesco Fanfani, Pierandrea De Iaco, Giacomo Corrado, Marcello Ceccaroni, Vincenzo Dario Mandato, Stefano Bogliolo, Jvan Casarin, Giorgia Monterossi, Ciro Pinelli, Giorgia Mangili, Gennaro Cormio, Giovanni Roviglione, Alice Bergamini, Anna Pesci, Luigi Frigerio, Silvia Uccella, Enrico Vizza, Giovanni Scambia, Fabio Ghezzi
OBJECTIVE: To investigate survival outcomes in endometrioid endometrial cancer (EEC) patients with single vs. multiple positive pelvic lymph nodes. METHODS: We performed a retrospective evaluation of all consecutive patients with histologically proven International Federation of Gynecology and Obstetrics (FIGO) stage IIIC1 EEC who underwent primary surgical treatment between 2004 and 2014 at seven Italian gynecologic oncology referral centers. Patients with pre- or intra-operative evidence of extra-uterine disease (including the presence of bulky nodes) and patients with stage IIIC2 disease were excluded, in order to obtain a homogeneous population...
November 2018: Journal of Gynecologic Oncology
Changhong Wang, Shan Qi, Cheng Xie, Chunfu Li, Pu Wang, Dongmei Liu
OBJECTIVE: The present study is to evaluate the biological functions of long non-coding RNA (lncRNA), X-inactive specific transcript, X-inactive specific transcript (XIST) in human epithelial ovarian cancer (EOC). METHODS: XIST was upregulated in EOC cell lines, CAOV3 and OVCAR3 cells by lentiviral transduction. The effects of XIST overexpression on cancer cell proliferation, invasion, chemosensitivity and in vivo tumor growth were investigated, respectively. Possible sponging interaction between XIST and human microRNA hsa-miR-214-3p was further evaluated...
November 2018: Journal of Gynecologic Oncology
Sangwon Han, Sungmin Woo, Chong Hyun Suh, Jong Jin Lee
OBJECTIVE: We describe a systematic review and meta-analysis of the performance of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) for detecting metastasis in ovarian cancer. METHODS: MEDLINE and Embase were searched for diagnostic accuracy studies that used ¹⁸F-FDG PET or PET/CT for pre-treatment staging, using surgical findings as the reference standard. Sensitivities and specificities were pooled and plotted in a hierarchic summary receiver operating characteristic plot...
November 2018: Journal of Gynecologic Oncology
Taylor R Cushman, Waqar Haque, Hari Menon, Chad G Rusthoven, E Brian Butler, Bin S Teh, Vivek Verma
OBJECTIVE: Women with cervical cancer (CC) found to have positive surgical margins, positive lymph nodes, and/or parametrial invasion receive a survival benefit from postoperative chemoradiotherapy (CRT) vs. radiation therapy (RT) alone. However, older women may not benefit to the same extent, as they are at increased risk of death from non-oncologic causes as well as toxicities from oncologic treatments. This study sought to evaluate whether there was a survival benefit of CRT over RT in elderly patients with cervical cancer...
November 2018: Journal of Gynecologic Oncology
Matilda X Lee, David Sp Tan
The 3-weekly regimen of carboplatin and paclitaxel is the backbone of first line adjuvant chemotherapy for advanced ovarian cancer. The landmark Japanese Gynaecologic Oncology Group (JGOG) 3016 study demonstrated significant improvements in progression-free survival and overall survival with dose dense weekly administration of paclitaxel in combination with 3-weekly carboplatin. However, efforts to replicate these benefits have failed in subsequent phase III trials. Weekly paclitaxel is purported to have enhanced antitumor activity, with stronger anti-angiogenic effects, and yet is better tolerated...
November 2018: Journal of Gynecologic Oncology
Xiaotian Luan, Yankui Wang
OBJECTIVE: Cervical cancer is one of the most common malignant tumors. Our previous results showed that long non-coding RNA (lncRNA) XLOC_006390 plays an important role in cervical cancer. In this study, we have explored the mechanism of action of lncRNA XLOC_006390. METHODS: LncRNA XLOC_006390 was proposed to exercise its function as a competing endogenous RNA (ceRNA), and its potential targeted miRNAs was predicted through the database LncBase Predicted v.2. Two miRNAs, miR-331-3p, and miR-338-3p, were chosen for the study...
November 2018: Journal of Gynecologic Oncology
Giorgio Bogani, Francesco Raspagliesi, Umberto Leone Roberti Maggiore, Andrea Mariani
Endometrial cancer (EC) represents the most common gynecological neoplasm in developed countries. Surgery is the mainstay of treatment for EC. Although EC is characterized by a high prevalence several features regarding its management are still unclear. In particular the execution of lymphadenectomy is controversial. The recent introduction of sentinel node mapping represents the mid-way between the execution and omission of node dissection in EC patients. In the present review we discuss the emerging role of sentinel node mapping in EC...
November 2018: Journal of Gynecologic Oncology
Klaus Pietzner, Sara Nasser, Sara Alavi, Silvia Darb-Esfahani, Mona Passler, Mustafa Zelal Muallem, Jalid Sehouli
The introduction of checkpoint inhibitors revolutionized immuno-oncology. The efficacy of traditional immunotherapeutics, like vaccines and immunostimulants was very limited due to persistent immune-escape strategies of cancer cells. Checkpoint inhibitors target these escape mechanisms and re-direct the immune system to anti-tumor toxicity. Phenomenal results have been reported in entities like melanoma, where no other therapy was able to demonstrate survival benefit, before the introduction of immunotherapeutics...
November 2018: Journal of Gynecologic Oncology
Kemal Güngördük, Osman Aşıcıoğlu, İsa Aykut Özdemir
OBJECTIVE: To evaluate the effectiveness of the pulmonary recruitment maneuver (PRM) at the end of the operation to decrease laparoscopy-induced abdominal or shoulder pain after gynecological oncologic surgery. METHODS: In total, 113 women undergoing laparoscopic surgery for malignant or premalignant gynecological lesions were assigned randomly to two groups: the PRM group (the patient was placed in the Trendelenburg position (30°) and the PRM, consisting of two manual pulmonary inflations to a maximum pressure of 40 cmH₂O) (n=54) and the control group (n=52)...
November 2018: Journal of Gynecologic Oncology
Koji Matsuo, Rachel S Mandelbaum, Hiroko Machida, Sanjay Purushotham, Brendan H Grubbs, Lynda D Roman, Jason D Wright
OBJECTIVE: To examine the association between tumor grade and survival for women with squamous cervical cancer. METHODS: This retrospective observational study utilized the Surveillance, Epidemiology, and End Result program data between 1983 and 2013 to examine women with squamous cervical cancer with known tumor differentiation grade. Multivariable analyses were performed to assess independent associations between tumor differentiation grade and survival. RESULTS: A total of 31,536 women were identified including 15,175 (48...
November 2018: Journal of Gynecologic Oncology
Do Hoon Kim, Chi Heum Cho, Sun Young Kwon, Nam Hee Ryoo, Dong Seok Jeon, Wonmok Lee, Jung Sook Ha
OBJECTIVE: We performed small-scale mutation and large genomic rearrangement (LGR) analysis of BRCA1/2 in ovarian cancer patients to determine the prevalence and the characteristics of the mutations. METHODS: All ovarian cancer patients who visited a single institution between September 2015 and April 2017 were included. Sanger sequencing, multiplex ligation-dependent probe amplification (MLPA), and long-range polymerase chain reaction (PCR) were performed to comprehensively study BRCA1/2 ...
November 2018: Journal of Gynecologic Oncology
Toshiyuki Kanno, Hideo Matsui, Yoshika Akizawa, Hirokazu Usui, Makio Shozu
OBJECTIVE: Highly effective chemotherapy for patients with low-risk gestational trophoblastic neoplasia (GTN) is associated with almost a 100% cure rate. However, 20%-30% of patients treated with chemotherapy need to change their regimens due to severe adverse events (SAEs) or drug resistance. We examined the treatment outcomes of second-line chemotherapy for patients with low-risk GTN. METHODS: Between 1980 and 2015, 281 patients with low-risk GTN were treated...
November 2018: Journal of Gynecologic Oncology
Koji Matsuo, Malcolm S Ross, Mayu Yunokawa, Marian S Johnson, Hiroko Machida, Kohei Omatsu, Merieme M Klobocista, Dwight D Im, Shinya Satoh, Tsukasa Baba, Yuji Ikeda, Stephen H Bush, Kosei Hasegawa, Erin A Blake, Munetaka Takekuma, Masako Shida, Masato Nishimura, Sosuke Adachi, Tanja Pejovic, Satoshi Takeuchi, Takuhei Yokoyama, Yutaka Ueda, Keita Iwasaki, Takahito M Miyake, Shiori Yanai, Tadayoshi Nagano, Tadao Takano, Mian Mk Shahzad, Frederick R Ueland, Joseph L Kelley, Lynda D Roman
No abstract text is available yet for this article.
November 2018: Journal of Gynecologic Oncology
Jiheum Paek, Elizabeth Kang, Peter C Lim
OBJECTIVE: Upper paraaortic lymph node dissection (UPALD) to the infrarenal level is one of the most challenging robotic procedures. Because robotic system has the limitation in robotic arm mobility. This surgical video introduces a novel robotic approach, lower pelvic port placement (LP3), to perform optimally and simultaneously both UPALD and pelvic procedures in gynecologic cancer patients using da Vinci Xi system. METHODS: The patient presented with high-grade endometrial cancer...
November 2018: Journal of Gynecologic Oncology
Koji Matsuo, Hiroko Machida, Rachel S Mandelbaum, Mikio Mikami, Takayuki Enomoto, Lynda D Roman, Jason D Wright
No abstract text is available yet for this article.
November 2018: Journal of Gynecologic Oncology
Tomone Watanabe, Mikio Mikami, Hidetaka Katabuchi, Shingo Kato, Masanori Kaneuchi, Masahiro Takahashi, Hidekatsu Nakai, Satoru Nagase, Hitoshi Niikura, Masaki Mandai, Yasuyuki Hirashima, Hiroyuki Yanai, Wataru Yamagami, Satoru Kamitani, Takahiro Higashi
OBJECTIVE: We aimed to propose a set of quality indicators (QIs) based on the clinical guidelines for cervical cancer treatment published by The Japan Society of Gynecologic Oncology, and to assess adherence to standard-of-care as an index of the quality of care for cervical cancer in Japan. METHODS: A panel of clinical experts devised the QIs using a modified Delphi method. Adherence to each QI was evaluated using data from a hospital-based cancer registry of patients diagnosed in 2013, and linked with insurance claims data, between October 1, 2012, and December 31, 2014...
November 2018: Journal of Gynecologic Oncology
Min Hyun Baek, Dae Yeon Kim, Seon Ok Kim, Ye Jee Kim, Young Han Park
OBJECTIVE: The impact of beta blockers (BBs) on survival outcomes in ovarian cancer was investigated. METHODS: By using Korean National Health Insurance Service Data, Cox proportional hazards regression was performed to analyze hazard ratios (HRs) with 95% confidence intervals (CIs) adjusting for confounding factors. RESULTS: Among 866 eligible patients, 206 (23.8%) were BB users and 660 (76.2%) were non-users. Among the 206 BB users, 151 (73...
November 2018: Journal of Gynecologic Oncology
Thanatip Tantivatana, Kanisa Rongsriyam
OBJECTIVE: To determine and compare treatment outcomes between cobalt-60 (Co-60) and iridium-192 (Ir-192) high dose rate (HDR) brachytherapy in stage IB2-IIIB cervical cancer patients at Department of Radiology, Faculty of Medicine Vajira Hospital, Navamindrahiraj University. METHODS: A retrospective cohort study of patients diagnosed with cervical cancer and treated with radiotherapy at the Department of Radiation Oncology, Faculty of Medicine Vajira Hospital between 2004 and 2014...
September 2018: Journal of Gynecologic Oncology
Giorgio Bogani, Umberto Leone Roberti Maggiore, Francesco Raspagliesi
No abstract text is available yet for this article.
September 2018: Journal of Gynecologic Oncology
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