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Journal of Gynecologic Oncology

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https://www.readbyqxmd.com/read/28028994/an-open-label-multicenter-phase-i-trial-of-a-cremophor-free-polymeric-micelle-formulation-of-paclitaxel-combined-with-carboplatin-as-a-first-line-treatment-for-advanced-ovarian-cancer-a-korean-gynecologic-oncology-group-study-kgog-3016
#1
Shin Wha Lee, Yong Man Kim, Young Tae Kim, Soon Beom Kang
OBJECTIVE: This phase I study aimed to determine the maximum tolerated dose (MTD) of Genexol-PM, when combined with carboplatin, as a first-line treatment in patients with advanced ovarian cancer. METHODS: This open-label, multicenter, phase I, dose-escalation study included 18 patients (median age: 59.0 years, range: 40-75 years) diagnosed with advanced epithelial ovarian cancer. All patients had measurable residual disease after debulking surgery. Patients were assigned to groups (n=6 each group) that received different doses of Genexol-PM (220, 260, and 300 mg/m², once every 3 weeks) and 5 area under the curve (AUC) carboplatin...
December 19, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28028993/update-on-immune-checkpoint-inhibitors-in-gynecological-cancers
#2
REVIEW
Valerie Heong, Natalie Ngoi, David Shao Peng Tan
In recent years, progress in our understanding of immune-modulatory signaling pathways in immune cells and the tumor microenvironment (TME) has led to rejuvenated interest in cancer immunotherapy. In particular, immunotherapy targeting the immune checkpoint receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell-death 1 (PD-1), and programmed cell-death ligand 1 (PD-L1) have demonstrated clinical activity in a wide variety of tumors, including gynecological cancers. This review will focus on the emerging clinical data on the therapeutic role of immune checkpoint inhibitors, and potential strategies to enhance the efficacy of this class of compounds, in the context of gynecological cancers...
December 14, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28028992/impact-of-histological-subtype-on-survival-in-patients-with-locally-advanced-cervical-cancer-that-were-treated-with-definitive-radiotherapy-adenocarcinoma-adenosquamous-carcinoma-versus-squamous-cell-carcinoma
#3
Eriko Yokoi, Seiji Mabuchi, Ryoko Takahashi, Yuri Matsumoto, Hiromasa Kuroda, Katsumi Kozasa, Tadashi Kimura
OBJECTIVE: To compare the survival outcomes of patients with cervical squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous carcinoma (AC/ASC) among patients with locally advanced cervical cancer that were treated with definitive radiotherapy. METHODS: The baseline characteristics and outcome data of patients with locally advanced cervical cancer who were treated with definitive radiotherapy between November 1993 and February 2014 were collected and retrospectively reviewed...
December 8, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28028991/computed-tomography-based-quantitative-assessment-of-lower-extremity-lymphedema-following-treatment-for-gynecologic-cancer
#4
Ji Sung Yoo, Seung Hyun Chung, Myong Cheol Lim, Young Jae Kim, Kwang Gi Kim, Ji Hye Hwang, Yun Hee Kim
OBJECTIVE: To develop an algorithmic quantitative skin and subcutaneous tissue volume measurement protocol for lower extremity lymphedema (LEL) patients using computed tomography (CT), to verify the usefulness of the measurement techniques in LEL patients, and to observe the structural characteristics of subcutaneous tissue according to the progression of LEL in gynecologic cancer. METHODS: A program for algorithmic quantitative analysis of lower extremity CT scans has been developed to measure the skin and subcutaneous volume, muscle compartment volume, and the extent of the peculiar trabecular area with a honeycombed pattern...
December 7, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28198168/clinical-statistics-of-gynecologic-cancers-in-japan
#5
REVIEW
Wataru Yamagami, Satoru Nagase, Fumiaki Takahashi, Kazuhiko Ino, Toru Hachisuga, Daisuke Aoki, Hidetaka Katabuchi
Cervical, endometrial, and ovarian cancers, have both high morbidity and mortality among the gynecologic malignant tumors in Japan. The present study was conducted using both the population-based cancer registry and the gynecologic cancer registry to elucidate the characteristics of gynecologic malignant tumors in Japan. Based on nationwide estimates from the population-based cancer registry in Japan, the morbidities and mortality of cervical, endometrial, and ovarian cancers were obtained and used for analysis...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27958685/pazopanib-as-a-second-line-treatment-for-uterine-and-ovarian-carcinosarcoma-a-single-institutional-study
#6
Tadaaki Nishikawa, Kosei Hasegawa, Akira Yabuno, Hiroyuki Yoshida, Masanori Yasuda, Eito Kozawa, Keiichi Fujiwara
No abstract text is available yet for this article.
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27958684/asgo-4th-international-workshop-on-gynecologic-oncology
#7
Yusuke Shibuya, Masafumi Toyoshima, Nobuo Yaegashi
No abstract text is available yet for this article.
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27958683/do-we-need-a-better-marker-for-successful-ovarian-cancer-surgery
#8
EDITORIAL
Sokbom Kang
No abstract text is available yet for this article.
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27958682/chemoradiotherapy-followed-by-consolidation-chemotherapy-involving-paclitaxel-and-carboplatin-and-in-figo-stage-iiib-iva-cervical-cancer-patients
#9
Seiji Mabuchi, Fumiaki Isohashi, Mika Okazawa, Fuminori Kitada, Shintaro Maruoka, Kazuhiko Ogawa, Tadashi Kimura
OBJECTIVE: To evaluate the efficacy and toxicity of paclitaxel plus carboplatin (TC)-based concurrent chemoradiotherapy (CCRT) followed by consolidation chemotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage IIIB/IVA cervical cancer patients. METHODS: We reviewed the medical records of FIGO stage IIIB/IVA cervical cancer patients (n=30) who had been intended to be treated with TC-based CCRT followed by consolidation chemotherapy (TC-CCRT-group) from April 2012-May 2016...
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27894169/the-gate-keeping-role-of-surgeons-with-regard-to-endometrial-cancers-in-lynch-syndrome
#10
EDITORIAL
Min Kyu Kim
No abstract text is available yet for this article.
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27894168/hysteroscopy-in-fertility-sparing-management-for-early-endometrial-cancer-a-double-edged-sword
#11
EDITORIAL
Jeong Yeol Park
No abstract text is available yet for this article.
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27894165/practice-guidelines-for-management-of-uterine-corpus-cancer-in-korea-a-korean-society-of-gynecologic-oncology-consensus-statement
#12
REVIEW
Shin Wha Lee, Taek Sang Lee, Dae Gy Hong, Jae Hong No, Dong Choon Park, Jae Man Bae, Seok Ju Seong, So Jin Shin, Woong Ju, Keun Ho Lee, Yoo Kyung Lee, Hanbyoul Cho, Chulmin Lee, Jiheum Paek, Hyun Jung Kim, Jeong Won Lee, Jae Weon Kim, Duk Soo Bae
Clinical practice guidelines for gynecologic cancers have been developed by many organizations. Although these guidelines have much in common in terms of the practice of standard of care for uterine corpus cancer, practice guidelines that reflect the characteristics of patients and healthcare and insurance systems are needed for each country. The Korean Society of Gynecologic Oncology (KSGO) published the first edition of practice guidelines for gynecologic cancer treatment in late 2006; the second edition was released in July 2010 as an evidence-based recommendation...
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27670261/perioperative-changes-in-serum-ca125-levels-a-prognostic-factor-for-disease-specific-survival-in-patients-with-ovarian-cancer
#13
Nienke Zwakman, Rafli van de Laar, Toon Van Gorp, Petra L M Zusterzeel, Marc P M L Snijders, Isabel Ferreira, Leon F A G Massuger, Roy F P M Kruitwagen
OBJECTIVE: In patients with advanced stage epithelial ovarian cancer (EOC) the volume of residual tumor after debulking is known as prognostic factor for survival. We wanted to examine the relationship between postoperative decline in serum CA125 and residual disease after cytoreductive surgery and evaluate perioperative changes in serum CA125 levels as predictor for disease-specific survival. METHODS: A retrospective study was conducted of patients with FIGO stage IIb-IV EOC treated with cytoreductive surgery, followed by chemotherapy between 1996 and 2010 in three hospitals in the Southeastern region of the Netherlands...
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27670260/surgical-manual-of-the-korean-gynecologic-oncology-group-ovarian-tubal-and-peritoneal-cancers
#14
REVIEW
Seob Jeon, Sung Jong Lee, Myong Cheol Lim, Taejong Song, Jaeman Bae, Kidong Kim, Jung Yun Lee, Sang Wun Kim, Suk Joon Chang, Jong Min Lee
The Surgery Treatment Modality Committee of the Korean Gynecologic Oncology Group has determined to develop a surgical manual to facilitate clinical trials and to improve communication between investigators by standardizing and precisely describing operating procedures. The literature on anatomic terminology, identification of surgical components, and surgical techniques were reviewed and discussed in depth to develop a surgical manual for gynecologic oncology. The surgical procedures provided here represent the minimum requirements for participating in a clinical trial...
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27670259/surgical-manual-of-the-korean-gynecologic-oncology-group-classification-of-hysterectomy-and-lymphadenectomy
#15
REVIEW
Maria Lee, Chel Hun Choi, Yi Kyeong Chun, Yun Hwan Kim, Kwang Beom Lee, Shin Wha Lee, Seung Hyuk Shim, Yong Jung Song, Ju Won Roh, Suk Joon Chang, Jong Min Lee
The Surgery Treatment Modality Committee of the Korean Gynecologic Oncologic Group (KGOG) has determined to develop a surgical manual to facilitate clinical trials and to improve communication between investigators by standardizing and precisely describing operating procedures. The literature on anatomic terminology, identification of surgical components, and surgical techniques were reviewed and discussed in depth to develop a surgical manual for gynecologic oncology. The surgical procedures provided here represent the minimum requirements for participating in a clinical trial...
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27670258/genetic-screening-in-young-women-diagnosed-with-endometrial-cancer
#16
Basilio Pecorino, Cinzia Rubino, Vito Fabio GuardalĂ , Antonio Galia, Paolo Scollo
OBJECTIVE: To evaluate the importance of Lynch syndrome associated risk screening in the patients aged less than 50 years affected from endometrial cancer. METHODS: From 2007 to 2014, 41 patients affected from endometrial cancer and aged less than 50 years underwent surgery at the Complex Operative Unit of Gynecology and Obstetrics, Cannizzaro Hospital of Catania, Italy. They were selected to undergo mismatch repair gene mutation analysis using immunohistochemistry (IHC; four markers: MLH1, MSH2, MSH6, PMS2) and microsatellite instability (MSI) test...
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27670257/pathologic-findings-at-risk-reducing-salpingo-oophorectomy-rrso-in-germline-brca-mutation-carriers-with-breast-cancer-significance-of-bilateral-rrso-at-the-optimal-age-in-germline-brca-mutation-carriers
#17
Young Jae Lee, Shin Wha Lee, Kyu Rae Kim, Kyung Hae Jung, Jong Won Lee, Yong Man Kim
OBJECTIVE: Most BRCA1/2 carriers do not undergo risk-reducing salpingo-oophorectomy (RRSO) by the recommended age. This study aimed to find the incidence of precursor lesions and cancer after RRSO. METHODS: We retrospectively reviewed breast cancer patients identified as BRCA mutation carriers who underwent RRSO at Asan Medical Center, Seoul, Korea, from 2010 to 2014. From 2013, all cases were examined according to the Sectioning and Extensively Examining the Fimbria (SEE/FIM) protocol and underwent immunohistochemically staining...
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27670256/fertility-preserving-treatment-with-hysteroscopic-resection-followed-by-progestin-therapy-in-young-women-with-early-endometrial-cancer
#18
Francesca Falcone, Giuseppe Laurelli, Simona Losito, Marilena Di Napoli, Vincenza Granata, Stefano Greggi
OBJECTIVE: To report our 15-year institutional experience of fertility-sparing treatment in young patients with early endometrial cancer (EC) treated by combined hysteroscopic resection and progestin therapy. METHODS: Twenty-eight patients (stage IA, G1 and 2 endometrioid EC) wishing to preserve their fertility were enrolled into this prospective study. Hysteroscopic resection was used to resect the tumor, endometrium adjacent to the tumor and myometrium underlying the tumor...
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27670255/dilatation-and-curettage-is-more-accurate-than-endometrial-aspiration-biopsy-in-early-stage-endometrial-cancer-patients-treated-with-high-dose-oral-progestin-and-levonorgestrel-intrauterine-system
#19
Da Hee Kim, Seok Ju Seong, Mi Kyoung Kim, Hyo Sook Bae, Mi La Kim, Bo Seong Yun, Yong Wook Jung, Jeong Yun Shim
OBJECTIVE: To determine whether less invasive endometrial (EM) aspiration biopsy is adequately accurate for evaluating treatment outcomes compared to the dilatation and curettage (D&C) biopsy in early-stage endometrial cancer (EC) patients treated with high dose oral progestin and levonorgestrel intrauterine system (LNG-IUS). METHODS: We conducted a prospective observational study with patients younger than 40 years who were diagnosed with clinical stage IA, The International Federation of Gynecology and Obstetrics grade 1 or 2 endometrioid adenocarcinoma and sought to maintain their fertility...
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27894167/salinomycin-reduces-stemness-and-induces-apoptosis-on-human-ovarian-cancer-stem-cell
#20
Hyun Gyo Lee, So Jin Shin, Hye Won Chung, Sang Hoon Kwon, Soon Do Cha, Jin Eui Lee, Chi Heum Cho
OBJECTIVE: Cancer stem cells (CSCs) represent a subpopulation of undifferentiated tumorigenic cells thought to be responsible for tumor initiation, maintenance, drug resistance, and metastasis. The role of CSCs in drug resistance and relapse of cancers could significantly affect outcomes of ovarian cancer patient. Therefore, therapies that target CSCs could be a promising approach for ovarian cancer treatment. The antibiotic salinomycin has recently been shown to deplete CSCs. In this study, we evaluated the effect of salinomycin on ovarian cancer stem cells (OCSCs), both alone and in combination with paclitaxel (PTX)...
November 14, 2016: Journal of Gynecologic Oncology
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