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Journal of Gynecologic Oncology

Cheng Chang Chang, Hui Chen Wang, Yu Ping Liao, Yu Chih Chen, Yu Chun Weng, Mu Hsien Yu, Hung Cheng Lai
OBJECTIVE: We hypothesized that DNA methylation of development-related genes may occur in endometrial cancer (EC)/ovarian cancer (OC) and may be detected in cervical scrapings. METHODS: We tested methylation status by quantitative methylation-specific polymerase chain reaction for 14 genes in DNA pools of endometrial and OC tissues. Tissues of EC/normal endometrium, OC/normal ovary, were verified in training set using cervical scrapings of 10 EC/10 OC patients and 10 controls, and further validated in the testing set using independent cervical scrapings in 30 EC/30 OC patients and 30 controls...
January 2018: Journal of Gynecologic Oncology
Chien An Chen, Chun Ju Chiang, Yun Yuan Chen, San Lin You, Shu Feng Hsieh, Chao Hsiun Tang, Wen Fang Cheng
OBJECTIVE: Adjuvant chemotherapy was introduced in patients with early-stage ovarian cancer (OC). The benefit of standard chemotherapeutic regimens including taxane has not been established. METHODS: Patients with early-stage OC from the National Health Insurance Research database of Taiwan who received platinum plus cyclophosphamide (CP) or platinum plus paclitaxel (PT) for 3-6 cycles were recruited, and the disease-free survival (DFS) and overall survival (OS) were determined...
January 2018: Journal of Gynecologic Oncology
Koji Matsuo, Hiroko Machida, Brendan H Grubbs, Anil K Sood, David M Gershenson
No abstract text is available yet for this article.
January 2018: Journal of Gynecologic Oncology
Yung Taek Ouh, Kyung Jin Min, Hyun Woong Cho, Moran Ki, Jin Kyoung Oh, Sang Yop Shin, Jin Hwa Hong, Jae Kwan Lee
OBJECTIVE: Knowledge regarding the prevalence and distribution of human papillomavirus (HPV) genotyping in healthy women is important in establishing strategies for cervical cancer screening and HPV vaccination. METHODS: A total of 18,170 women who visited a Korean Medical Institute for health check-ups were recruited retrospectively; they underwent HPV genotyping and conventional cervical cytology. An HPV DNA test was performed using the Anyplex™ II HPV 28 detection system (Seegene) or HPV Liquid Bead Microarray (Osang Healthcare)...
January 2018: Journal of Gynecologic Oncology
E Sun Paik, Ji Hye Kim, Tae Joong Kim, Jeong Won Lee, Byoung Gie Kim, Duk Soo Bae, Chel Hun Choi
OBJECTIVE: We compared survival outcomes of advanced serous type epithelial ovarian cancer (EOC) patients with normal-sized ovaries and enlarged-ovarian tumors by propensity score matching analysis. METHODS: The medical records of EOC patients treated at Samsung Medical Center between 2002 and 2015 were reviewed retrospectively. We investigated EOC patients with high grade serous type histology and International Federation of Gynecology and Obstetrics (FIGO) stage IIIB, IIIC, or IV who underwent primary debulking surgery (PDS) and adjuvant chemotherapy to identify patients with normal-sized ovaries...
January 2018: Journal of Gynecologic Oncology
Ali Ayhan, Nazlı Topfedaisi Ozkan, Mustafa Erkan Sarı, Husnu Celik, Murat Dede, Özgür Akbayır, Kemal Güngördük, Hanifi Şahin, Ali Haberal, Tayfun Güngör, Macit Arvas, Mehmet Mutlu Meydanlı
OBJECTIVE: The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in patients with stage III ovarian high-grade serous carcinoma (HGSC). METHODS: A multicenter, retrospective department database review was performed to identify patients with ovarian HGSC at 6 gynecologic oncology centers in Turkey. A total of 229 node-positive women with stage III ovarian HGSC who had undergone maximal or optimal cytoreductive surgery plus systematic lymphadenectomy followed by paclitaxel plus carboplatin combination chemotherapy were included...
January 2018: Journal of Gynecologic Oncology
Koji Matsuo, Muneaki Shimada, Tsuyoshi Saito, Kazuhiro Takehara, Hideki Tokunaga, Yoh Watanabe, Yukiharu Todo, Ken Ichirou Morishige, Mikio Mikami, Toru Sugiyama
OBJECTIVE: To examine the surgical-pathological predictors of para-aortic lymph node (PAN) metastasis at radical hysterectomy, and for PAN recurrence among women who did not undergo PAN dissection at radical hysterectomy. METHODS: This is a retrospective analysis of a nation-wide cohort study of surgically-treated stage IB-IIB cervical cancer (n=5,620). Multivariate models were used to identify independent surgical-pathological predictors for PAN metastasis/recurrence...
January 2018: Journal of Gynecologic Oncology
Koji Matsuo, Brendan H Grubbs, Mikio Mikami
No abstract text is available yet for this article.
January 2018: Journal of Gynecologic Oncology
Shinsuke Sasada, Mayu Yunokawa, Yae Takehara, Mitsuya Ishikawa, Shunichi Ikeda, Tomoyasu Kato, Kenji Tamura
OBJECTIVE: Though there are no evidences that postoperative therapy improves overall survival (OS) in stage I-II endometrial carcinoma, many women receive postoperative radiation or chemotherapy. This study aimed to investigate the baseline risk of recurrence after complete resection without any adjuvant therapies and to suppose the validity of postoperative therapy for stage I-II endometrial carcinoma. METHODS: Charts for patients with stage I-II endometrial carcinoma who underwent operation without postoperative therapy between January 2005 and December 2011 were retrospectively reviewed and the baseline risk of recurrence and prognosis were assessed...
January 2018: Journal of Gynecologic Oncology
Liselotte Coorevits, Ans Traen, Luc Bingé, Jo Van Dorpe, Marleen Praet, Jerina Boelens, Elizaveta Padalko
OBJECTIVE: Human papillomavirus (HPV) testing is widely incorporated into cervical cancer screening strategies. Current screening requires pelvic examination for cervical sampling, which may compromise participation. The acceptance could be raised by introducing testing on vaginal swabs. We explored the interchangeability of vaginal swabs and cervical smears for HPV testing, by means of a prospective study conducted in female sex workers (FSWs). Besides, we report on the occurrence of 32 different HPV genotypes in FSW with low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL)...
January 2018: Journal of Gynecologic Oncology
Xiyi Jiang, Huijuan Tang, Tianhui Chen
Cancer has become a major disease burden across the globe. It was estimated that 4.29 million new incident cases and 2.81 million death cases of cancer would occur in 2015 in China, with the age-standardized incidence rate (ASIR) of 201.1 per 100,000 and age-standardized mortality rate (ASMR) of 126.9 per 100,000, respectively. For females, 2 of the top 10 most common types of cancer would be gynecologic cancers, with breast cancer being the most prevalent (268.6 thousand new incident cases) and cervical cancer being the 7th most common cancer (98...
January 2018: Journal of Gynecologic Oncology
Mi Kyung Kim, In Ho Lee, Ki Heon Lee
OBJECTIVE: To evaluate the clinical outcomes of vaginal intraepithelial neoplasia (VAIN) and to assess the risk of recurrence and progression to invasive vaginal carcinoma. METHODS: A retrospective review of the clinicopathologic data and clinical outcomes was performed on patients who were diagnosed with VAIN at a single center between January 2000 and July 2016. Demographics, treatments, and clinical outcomes were abstracted from medical records. RESULTS: A total of 576 patients with VAIN1-3 were included in the study analysis...
January 2018: Journal of Gynecologic Oncology
Kwang Beom Lee, Young Saing Kim, Jong Min Lee
OBJECTIVE: To evaluate the oncologic outcomes of adjuvant chemotherapy (CT) alone after radical surgery. METHODS: We retrospectively reviewed the medical records of patients who underwent type C radical hysterectomy and pelvic lymphadenectomy with or without paraaortic lymphadenectomy for stage IB-IIA cervical cancer from March 2006 to December 2014 at 2 academic medical centers in Korea. Adjuvant CT alone for patients who met the Sedlis criteria or had lymph node (LN) involvement...
January 2018: Journal of Gynecologic Oncology
Wei Jiang, Libing Xiang, Xuan Pei, Tiancong He, Xuxia Shen, Xiaohua Wu, Huijuan Yang
OBJECTIVE: The predictive and prognostic role of KRAS mutations in cervical cancer remains inconclusive. The aim of this study was to explore the clinicopathological and prognostic relevance of KRAS mutations in invasive cervical cancers (ICC). METHODS: Reverse transcription polymerase chain reaction (PCR) and Sanger sequencing were employed to detect KRAS mutations in 876 ICC patients. Quantitative real-time PCR was used to detect human papillomavirus (HPV) 16 and HPV 18...
January 2018: Journal of Gynecologic Oncology
Hyun Jun Kim, Youjin Kim, Su Jin Lee, Jeeyun Lee, Se Hoon Park
OBJECTIVE: In the treatment of metastatic soft tissue sarcoma (STS), pazopanib is considered a standard treatment after failure of chemotherapy. We retrospectively investigated outcomes of pazopanib in patients with metastatic uterine STS. METHODS: A retrospective study was performed on 35 consecutive patients with uterine STS treated with oral pazopanib 800 mg daily as salvage therapy for metastatic disease between September 2013 and December 2015. Endpoints included response rate, survival, and safety...
January 2018: Journal of Gynecologic Oncology
Enrico Vizza, Benito Chiofalo, Giuseppe Cutillo, Emanuela Mancini, Ermelinda Baiocco, Ashanti Zampa, Arabella Bufalo, Giacomo Corrado
OBJECTIVE: To evaluate the feasibility and the safety of robotic single-site radical hysterectomy (RSSRH) plus pelvic lymphadenectomy (PL) in endometrial or cervical cancer. METHODS: Patients with endometrial cancer (EC) International Federation of Gynecology and Obstetrics (FIGO) stage II, early cervical cancer (ECC) FIGO stage IB1 or locally advanced cervical cancer (LACC) FIGO stage IB2-IIB with clinical response ≥50% after neo-adjuvant chemotherapy (NACT) were enrolled in a prospective cohort trial...
January 2018: Journal of Gynecologic Oncology
Pluvio J Coronado, Agnieszka Rychlik, Maria A Martínez-Maestre, Laura Baquedano, María Fasero, Aida García-Arreza, Sara Morales, Daniel M Lubian, Ignacio Zapardiel
OBJECTIVE: To assess the impact of lymph node dissection (LND) on morbidity, survival, and cost for intermediate-risk endometrial cancers (IREC). METHODS: A multicenter retrospective cohort of 720 women with IREC (endometrioid histology with myometrial invasion <50% and grade 3; or myometrial invasion ≥50% and grades 1-2; or cervical involvement and grades 1-2) was carried out. All patients underwent hysterectomy and bilateral salpingo-oophorectomy. A matched pair analysis identified 178 pairs (178 with LND and 178 without it) equal in age, body mass index, co-morbidities, American Society of Anesthesiologist score, myometrial invasion, and surgical approach...
January 2018: Journal of Gynecologic Oncology
Sokbom Kang
No abstract text is available yet for this article.
November 2017: Journal of Gynecologic Oncology
Jeong Yeol Park
No abstract text is available yet for this article.
November 2017: Journal of Gynecologic Oncology
Juan Luis Alcázar, Begoña Gastón, Beatriz Navarro, Rocío Salas, Juana Aranda, Stefano Guerriero
OBJECTIVE: To compare the diagnostic accuracy of transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) for detecting myometrial infiltration (MI) in endometrial carcinoma. METHODS: An extensive search of papers comparing TVS and MRI in assessing MI in endometrial cancer was performed in MEDLINE (PubMed), Web of Science, and Cochrane Database from January 1989 to January 2017. Quality was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool...
November 2017: Journal of Gynecologic Oncology
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