journal
MENU ▼
Read by QxMD icon Read
search

Journal of Gynecologic Oncology

journal
https://www.readbyqxmd.com/read/28382802/major-clinical-research-advances-in-gynecologic-cancer-in-2016-10-year-special-edition
#1
REVIEW
Dong Hoon Suh, Miseon Kim, Kidong Kim, Hak Jae Kim, Kyung Hun Lee, Jae Weon Kim
In 2016, 13 topics were selected as major research advances in gynecologic oncology. For ovarian cancer, study results supporting previous ones regarding surgical preventive strategies were reported. There were several targeted agents that showed comparable responses in phase III trials, including niraparib, cediranib, and nintedanib. On the contrary to our expectations, dose-dense weekly chemotherapy regimen failed to prove superior survival outcomes compared with conventional triweekly regimen. Single-agent non-platinum treatment to prolong platinum-free-interval in patients with recurrent, partially platinum-sensitive ovarian cancer did not improve and even worsened overall survival (OS)...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28382801/surgical-treatment-of-early-ovarian-cancer-with-compartmental-resection-of-regional-lymphatic-network-and-indocyanine-green-guided-targeted-compartmental-lymphadenectomy-tcl-paraaortic-part
#2
Rainer Kimmig, Paul Buderath, Pawel Mach, Peter Rusch, Bahriye Aktas
OBJECTIVE: Whether pelvic and para-aortic lymphadenectomy is of therapeutic benefit in advanced ovarian cancer will remain unclear until the publication of the Arbeitsgemeinschaft Gynäkologische Onkologie lymphadenectomy in ovarian neoplasms (AGO LION) trial. In early ovarian cancer, however, lymphadenectomy seems mandatory for diagnostic and also therapeutic reasons. METHODS: Complete systematic lymphadenectomy is accompanied by morbidity which may be reduced by sentinel node biopsy already established for several solid tumors...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28382800/prevention-of-lymphocele-by-using-gelatin-thrombin-matrix-as-a-tissue-sealant-after-pelvic-lymphadenectomy-in-patients-with-gynecologic-cancers-a-prospective-randomized-controlled-study
#3
Yun Hwan Kim, Hyun Joo Shin, Woong Ju, Seung Cheol Kim
OBJECTIVE: This prospective randomized controlled pilot study aimed to find whether gelatin-thrombin matrix used as a tissue sealant (FloSeal) can prevent the occurrence of pelvic lymphocele in patients with gynecologic cancer who has undergone pelvic lymphadenectomy. METHODS: Each patient, who undergo a laparotomic pelvic lymph node dissection on both sides, was randomly assigned for FloSeal application on 1 side of the pelvis. The other side of the pelvis without any product application being the control side...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28382799/elevated-plasma-fibrinogen-levels-and-prognosis-of-epithelial-ovarian-cancer-a-cohort-study-and-meta-analysis
#4
Yanlin Luo, Hee Seung Kim, Miseon Kim, Maria Lee, Yong Sang Song
OBJECTIVE: To evaluate the effect of elevated plasma fibrinogen levels on the prognosis of epithelial ovarian cancer (EOC). METHODS: We reviewed the data of 217 patients with advanced-stage EOC between 2000 and 2012, and investigated the prognostic role of elevated plasma fibrinogen levels compared with serum CA-125 levels, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). For further evaluation, we performed a meta-analysis using 5 cohort studies published to July 2015, including our cohort study after a literature review...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28382798/increased-risk-of-breast-cancer-in-women-with-uterine-myoma-a-nationwide-population-based-case-control-study
#5
Jenn Jhy Tseng, Yi Huei Chen, Hsiu Yin Chiang, Ching Heng Lin
OBJECTIVE: To evaluate if uterine myoma is associated with breast cancer. METHODS: This case-control study used a nationwide database in Taiwan. We identified 24,315 patients with newly diagnosed breast cancer as cases and matched them with 24,281 patients without breast cancer on age, sex, urbanization, income, and initial diagnosis date. Patients with prior mastectomy were excluded. We used logistic regression analysis to assess the association between uterine myoma and breast cancer while adjusting for confounders...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28382797/randomized-study-between-radical-surgery-and-radiotherapy-for-the-treatment-of-stage-ib-iia-cervical-cancer-20-year-update
#6
Fabio Landoni, Alessandro Colombo, Rodolfo Milani, Franco Placa, Vanna Zanagnolo, Costantino Mangioni
OBJECTIVE: Stage IB-IIA cervical carcinoma can be equally cured either by radical surgery or radiotherapy (RT). Albeit such policies show the same efficacy, they carry a different morbidity. This is an update after 20 years of a previously published randomized trial of RT vs. surgery in the treatment of stage IB-IIA cervical cancers to assess long-term survival and morbidity and the different pattern of relapse between the 2 modalities. METHODS: Between September 1986 and December 1991, women referred for a newly diagnosed stage IB and IIA cervical carcinoma were randomized to radical surgery or RT...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28382796/inhibition-of-autophagy-protein-lc3a-as-a-therapeutic-target-in-ovarian-clear-cell-carcinomas
#7
Morikazu Miyamoto, Masashi Takano, Tadashi Aoyama, Hiroaki Soyama, Tomoyuki Yoshikawa, Hitoshi Tsuda, Kenichi Furuya
OBJECTIVE: Ovarian clear cell carcinoma (CCC) is one of histological subtypes showing poor prognosis due to chemoresistance. The association of autophagy-related proteins and clinical implementation in CCC has not been determined. METHODS: The present study investigated whether expression of autophagy-related protein, light chain 3A (LC3A), was related with prognoses in the patients with CCC using immuno-histochemical stainings, and whether inhibition of autophagy modified the sensitivity to cisplatin in CCC cells in vitro...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28382795/prognostic-significance-of-preoperative-%C3%A2-%C3%A2-f-fdg-pet-ct-in-uterine-leiomyosarcoma
#8
Jeong Yeol Park, Jeong Won Lee, Hyun Ju Lee, Jong Jin Lee, Seung Hwan Moon, Seo Young Kang, Gi Jeong Cheon, Hyun Hoon Chung
OBJECTIVE: Uterine leiomyosarcoma (LMS) is a rare and aggressive disease with poor outcome. Due to its rarity and conflict of data, investigation on finding prognostic factor is challenging. The aim of the study was to investigate the prognostic significance of preoperative ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) in uterine LMS. METHODS: This was a retrospective observational cohort study in 3 tertiary referral hospitals...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28382794/practice-guidelines-for-management-of-cervical-cancer-in-korea-a-korean-society-of-gynecologic-oncology-consensus-statement
#9
REVIEW
Myong Cheol Lim, Maria Lee, Seung Hyuk Shim, Eun Ji Nam, Jung Yun Lee, Hyun Jung Kim, Yoo Young Lee, Kwang Beom Lee, Jeong Yeol Park, Yun Hwan Kim, Kyung Do Ki, Yong Jung Song, Hyun Hoon Chung, Sunghoon Kim, Jeong Won Lee, Jae Weon Kim, Duk Soo Bae, Jong Min Lee
Clinical practice guidelines for gynecologic cancers have been developed by academic society from several countries. Each guideline reflected their own insurance system and unique medical environment, based on the published evidence. The Korean Society of Gynecologic Oncology (KSGO) published the first edition of practice guidelines for gynecologic cancer treatment in late 2006; the second edition was released in July 2010 as an evidence-based recommendation. The Guidelines Revision Committee was established in 2015 and decided to develop the third edition of the guidelines in an advanced format based on evidence-based medicine, embracing up-to-date clinical trials and qualified Korean data...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28028994/an-open-label-multicenter-phase-i-trial-of-a-cremophor-free-polymeric-micelle-formulation-of-paclitaxel-combined-with-carboplatin-as-a-first-line-treatment-for-advanced-ovarian-cancer-a-korean-gynecologic-oncology-group-study-kgog-3016
#10
Shin Wha Lee, Yong Man Kim, Young Tae Kim, Soon Beom Kang
OBJECTIVE: This phase I study aimed to determine the maximum tolerated dose (MTD) of Genexol-PM, when combined with carboplatin, as a first-line treatment in patients with advanced ovarian cancer. METHODS: This open-label, multicenter, phase I, dose-escalation study included 18 patients (median age: 59.0 years, range: 40-75 years) diagnosed with advanced epithelial ovarian cancer. All patients had measurable residual disease after debulking surgery. Patients were assigned to groups (n=6 each group) that received different doses of Genexol-PM (220, 260, and 300 mg/m², once every 3 weeks) and 5 area under the curve (AUC) carboplatin...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28198168/clinical-statistics-of-gynecologic-cancers-in-japan
#11
REVIEW
Wataru Yamagami, Satoru Nagase, Fumiaki Takahashi, Kazuhiko Ino, Toru Hachisuga, Daisuke Aoki, Hidetaka Katabuchi
Cervical, endometrial, and ovarian cancers, have both high morbidity and mortality among the gynecologic malignant tumors in Japan. The present study was conducted using both the population-based cancer registry and the gynecologic cancer registry to elucidate the characteristics of gynecologic malignant tumors in Japan. Based on nationwide estimates from the population-based cancer registry in Japan, the morbidities and mortality of cervical, endometrial, and ovarian cancers were obtained and used for analysis...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28028993/update-on-immune-checkpoint-inhibitors-in-gynecological-cancers
#12
REVIEW
Valerie Heong, Natalie Ngoi, David Shao Peng Tan
In recent years, progress in our understanding of immune-modulatory signaling pathways in immune cells and the tumor microenvironment (TME) has led to rejuvenated interest in cancer immunotherapy. In particular, immunotherapy targeting the immune checkpoint receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell-death 1 (PD-1), and programmed cell-death ligand 1 (PD-L1) have demonstrated clinical activity in a wide variety of tumors, including gynecological cancers. This review will focus on the emerging clinical data on the therapeutic role of immune checkpoint inhibitors, and potential strategies to enhance the efficacy of this class of compounds, in the context of gynecological cancers...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28028992/impact-of-histological-subtype-on-survival-in-patients-with-locally-advanced-cervical-cancer-that-were-treated-with-definitive-radiotherapy-adenocarcinoma-adenosquamous-carcinoma-versus-squamous-cell-carcinoma
#13
Eriko Yokoi, Seiji Mabuchi, Ryoko Takahashi, Yuri Matsumoto, Hiromasa Kuroda, Katsumi Kozasa, Tadashi Kimura
OBJECTIVE: To compare the survival outcomes of patients with cervical squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous carcinoma (AC/ASC) among patients with locally advanced cervical cancer that were treated with definitive radiotherapy. METHODS: The baseline characteristics and outcome data of patients with locally advanced cervical cancer who were treated with definitive radiotherapy between November 1993 and February 2014 were collected and retrospectively reviewed...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28028991/computed-tomography-based-quantitative-assessment-of-lower-extremity-lymphedema-following-treatment-for-gynecologic-cancer
#14
Ji Sung Yoo, Seung Hyun Chung, Myong Cheol Lim, Young Jae Kim, Kwang Gi Kim, Ji Hye Hwang, Yun Hee Kim
OBJECTIVE: To develop an algorithmic quantitative skin and subcutaneous tissue volume measurement protocol for lower extremity lymphedema (LEL) patients using computed tomography (CT), to verify the usefulness of the measurement techniques in LEL patients, and to observe the structural characteristics of subcutaneous tissue according to the progression of LEL in gynecologic cancer. METHODS: A program for algorithmic quantitative analysis of lower extremity CT scans has been developed to measure the skin and subcutaneous volume, muscle compartment volume, and the extent of the peculiar trabecular area with a honeycombed pattern...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27894167/salinomycin-reduces-stemness-and-induces-apoptosis-on-human-ovarian-cancer-stem-cell
#15
Hyun Gyo Lee, So Jin Shin, Hye Won Chung, Sang Hoon Kwon, Soon Do Cha, Jin Eui Lee, Chi Heum Cho
OBJECTIVE: Cancer stem cells (CSCs) represent a subpopulation of undifferentiated tumorigenic cells thought to be responsible for tumor initiation, maintenance, drug resistance, and metastasis. The role of CSCs in drug resistance and relapse of cancers could significantly affect outcomes of ovarian cancer patient. Therefore, therapies that target CSCs could be a promising approach for ovarian cancer treatment. The antibiotic salinomycin has recently been shown to deplete CSCs. In this study, we evaluated the effect of salinomycin on ovarian cancer stem cells (OCSCs), both alone and in combination with paclitaxel (PTX)...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27894166/the-detection-of-sentinel-lymph-nodes-in-laparoscopic-surgery-for-uterine-cervical-cancer-using-99m-technetium-tin-colloid-indocyanine-green-and-blue-dye
#16
Tomohito Tanaka, Yoshito Terai, Keisuke Ashihara, Satoshi Tsunetoh, Hiroyuki Akagi, Takashi Yamada, Masahide Ohmichi
OBJECTIVE: Our objective was to determine the feasibility and detection rates and clarify the most effective combination of injected tracer types for sentinel lymph node (SLN) mapping in uterine cervical cancer in patients who have undergone laparoscopic surgery or neoadjuvant chemotherapy (NAC). METHODS: A total of 119 patients with cervical cancer underwent SLN biopsy at radical hysterectomy using three types of tracers. The various factors related to side-specific detection rate, sensitivity, and false negative (FN) rate were analyzed...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27894164/preoperative-ca125-and-fibrinogen-in-patients-with-endometrial-cancer-a-risk-model-for-predicting-lymphovascular-space-invasion
#17
Xingchen Zhou, Husheng Wang, Xipeng Wang
OBJECTIVE: The aim of this study was to build a model to predict the risk of lymphovascular space invasion (LVSI) in women with endometrial cancer (EC). METHODS: From December 2010 to June 2013, 211 patients with EC undergoing surgery at Shanghai First Maternity and Infant Hospital were enrolled in this retrospective study. Those patients were divided into a positive LVSI group and a negative LVSI group. The clinical and pathological characteristics were compared between the two groups; logistic regression was used to explore risk factors associated with LVSI occurrence...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27894163/feature-of-amenorrhea-in-postoperative-tamoxifen-users-with-breast-cancer
#18
Hoon Kim, Wonshik Han, Seung Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi
OBJECTIVE: Tamoxifen has been used to prevent the recurrence of breast cancer. However, tamoxifen-users frequently experience amenorrhea and it can be confused from that caused by other hormonal abnormalities. In amenorrheic patients without breast cancer, clinicians usually measure the sex hormone levels that are known to be associated with ovarian or menstrual function. This study aimed to investigate the feature of female sex hormones in premenopausal breast cancer patients undergoing tamoxifen treatment...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27819411/development-of-the-short-version-of-the-gynecologic-cancer-lymphedema-questionnaire-gclq-7
#19
Se Ik Kim, Namjoo Kim, Seonjoo Lee, Sujung Lee, Jungnam Joo, Sang Soo Seo, Seung Hyun Chung, Sang Yoon Park, Myong Cheol Lim
OBJECTIVE: The Gynecologic Cancer Lymphedema Questionnaire (GCLQ) was designed to identify gynecologic cancer patients with lower limb lymphedema (LLL). The questionnaire consists of 20 items distributed over 7 symptom clusters. The present study aimed to develop an abridged form of the GCLQ for simpler screening and more effective follow-up of LLL. METHODS: Data that had been collected for the development and validation of the Korean version of the GCLQ (GCLQ-K) were used in this study...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27819410/comparing-and-evaluating-the-efficacy-of-methotrexate-and-actinomycin-d-as-first-line-single-chemotherapy-agents-in-low-risk-gestational-trophoblastic-disease
#20
Young Jae Lee, Jeong Yeol Park, Dae Yeon Kim, Dae Shik Suh, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam
OBJECTIVE: The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS: We conducted a retrospective study of 126 patients with GTD who were treated between 2000 and 2013. A total of 71 patients with LR GTD were treated with MTX (8-day regimen or weekly regimen, n=53) or ACT-D (bi-weekly pulsed regimen or 5-day regimen, n=18)...
March 2017: Journal of Gynecologic Oncology
journal
journal
42137
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"