journal
MENU ▼
Read by QxMD icon Read
search

Japanese Dental Science Review

journal
https://www.readbyqxmd.com/read/29755619/molecularly-targeted-therapy-for-the-oral-cancer-stem-cells
#1
REVIEW
Yuichi Ohnishi, Hiroki Yasui, Masami Nozaki, Masahiro Nakajima
Human cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the underlying mechanisms remain unclear. Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR)/ErbB2, has antiproliferative effects and is used to treat patients with ErbB2-positive metastatic breast cancer...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29755618/wear-of-resin-composites-current-insights-into-underlying-mechanisms-evaluation-methods-and-influential-factors
#2
REVIEW
Akimasa Tsujimoto, Wayne W Barkmeier, Nicholas G Fischer, Kie Nojiri, Yuko Nagura, Toshiki Takamizawa, Mark A Latta, Masashi Miazaki
The application of resin composites in dentistry has become increasingly widespread due to the increased aesthetic demands of patients, improvements in the formulation of resin composites, and the ability of these materials to bond to tooth structures, together with concerns about dental amalgam fillings. As resistance to wear is an important factor in determining the clinical success of resin composite restoratives, this review article defines what constitutes wear and describes the major underlying phenomena involved in this process...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29755617/regulation-of-defensive-function-on-gingival-epithelial-cells-can-prevent-periodontal-disease
#3
REVIEW
Tsuyoshi Fujita, Tetsuya Yoshimoto, Mikihito Kajiya, Kazuhisa Ouhara, Shinji Matsuda, Tasuku Takemura, Keiichi Akutagawa, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi Kurihara
Periodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier against bacterial invasion and a part of the innate immune response to infectious inflammation in periodontal tissue. The disorganization of cell-cell interactions and subsequent inflammation contribute to the initiation of periodontal disease...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29755616/histological-and-immunological-characteristics-of-the-junctional-epithelium
#4
REVIEW
Masanori Nakamura
The continuity of epithelial tissue is collapsed by tooth eruption. The junctional epithelium (JE) is attached to the tooth surface by hemidesmosomes, which constitutes the front-line defense against periodontal bacterial infection. JE constitutively expresses intercellular adhesion molecule-1 (ICAM-1), and neutrophils and lymphocytes penetrate into JE via interaction between ICAM-1 and LFA-1 expressed on the surface of these migrating cells. JE also expresses cytokines and chemokines. These functions of JE are maintained even in germ-free condition...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29755615/-candida-is-a-protractive-factor-of-chronic-oral-ulcers-among-usual-outpatients
#5
REVIEW
Haruhiko Terai, Takaaki Ueno, Yoshifumi Suwa, Michi Omori, Kayoko Yamamoto, Shin Kasuya
Although many oral ulcers have similar clinical appearances, their etiologies can range from reactive to neoplastic to oral manifestations of dermatological diseases. In patients with an HIV infection, fungal diseases may cause ulceration in the oral cavity; however, there have been few studies of oral ulcerative lesions associated with Candida in patients without an HIV infection. Nevertheless, we encountered chronic oral ulcer associated with Candida among our frequent outpatients without an HIV infection...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29755614/implant-treatment-in-ultra-aged-society
#6
REVIEW
Yuji Sato, Noboru Kitagawa, Akio Isobe
Implant therapy is gaining presence as a prosthodontic treatment option. However, the graying of the population has led to an increase in the number of older adults requiring special consideration in implant treatment because of their systemic health problems. Additionally, with the growth of the elderly population in need of long-term care, a greater number of older adults who have received implant treatment are receiving long-term care, raising various issues that need to be addressed. In the present review article, we describe the significance of implant treatment in older adults, issues when performing implant treatment in geriatric patients, and measures to be taken when implant patients have lapsed into a state of requiring long-term care...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29629000/two-novel-mechanisms-for-maintenance-of-stemness-in-mesenchymal-stem-cells-scrg1-bst1-axis-and-cell-cell-adhesion-through-n-cadherin
#7
REVIEW
Naoyuki Chosa, Akira Ishisaki
Mesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, human MSCs are suitable candidates for use in regenerative medicine and cell therapies. Upon activation by tissue damage, MSCs contribute to tissue repair through a multitude of processes such as self-renewal, migration, and differentiation. However, loss of self-renewal and multi-lineage differentiation potential occurs at a high rate during cell doubling. Effective MSC therapies require the establishment of new techniques that preserve MSC multipotency after lengthy cell expansions...
February 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29628999/a-review-on-non-syndromic-tooth-agenesis-associated-with-pax9-mutations
#8
REVIEW
Nurul Hasyiqin Fauzi, Yunita Dewi Ardini, Zarina Zainuddin, Widya Lestari
Tooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of several genes for tooth epithelium and mesenchyme odontogenesis. Mutation of candidate genes PAX9 and MSX1 have been identified as the main causes of hypodontia and oligodontia; meanwhile, AXIN2 mutation is associated with anodontia...
February 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29628998/role-of-streptococcus-mutans-surface-proteins-for-biofilm-formation
#9
REVIEW
Michiyo Matsumoto-Nakano
Streptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to modulate environmental stress responses...
February 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29628997/cancer-metabolism-new-insights-into-classic-characteristics
#10
REVIEW
Yasumasa Kato, Toyonobu Maeda, Atsuko Suzuki, Yuh Baba
Initial studies of cancer metabolism in the early 1920s found that cancer cells were phenotypically characterized by aerobic glycolysis, in that these cells favor glucose uptake and lactate production, even in the presence of oxygen. This property, called the Warburg effect, is considered a hallmark of cancer. The mechanism by which these cells acquire aerobic glycolysis has been uncovered. Acidic extracellular fluid, secreted by cancer cells, induces a malignant phenotype, including invasion and metastasis...
February 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29628996/regulatory-mechanisms-of-branching-morphogenesis-in-mouse-submandibular-gland-rudiments
#11
REVIEW
Masanori Kashimata, Toru Hayashi
Branching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial-mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators of branching morphogenesis of salivary glands. In addition, functional microRNAs (miRNAs) have recently been reported to be present in the developing submandibular gland...
February 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29628995/the-shape-of-progress
#12
EDITORIAL
Masahito Sumitomo
No abstract text is available yet for this article.
February 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29201258/molecular-mechanisms-of-porphyromonas-gingivalis-host-cell-interaction-on-periodontal-diseases
#13
REVIEW
Masaaki Nakayama, Naoya Ohara
Porphyromonas gingivalis ( P. gingivalis ) is a major oral pathogen and associated with periodontal diseases including periodontitis and alveolar bone loss. In this review, we indicate that two virulence factors, which are hemoglobin receptor protein (HbR) and cysteine proteases "gingipains", expressed by P. gingivalis have novel functions on the pathogenicity of P. gingivalis . P. gingivalis produces three types of gingipains and concomitantly several adhesin domains. Among the adhesin domains, hemoglobin receptor protein (HbR), also called HGP15, has the function of induction of interleukin-8 (IL-8) expression in human gingival epithelial cells, indicating the possibility that HbR is associated with P...
November 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29201257/muscle-power-during-intravenous-sedation
#14
REVIEW
Nobuyuki Matsuura
Intravenous sedation is effective to reduce fear and anxiety in dental treatment. It also has been used for behavior modification technique in dental patients with special needs. Midazolam and propofol are commonly used for intravenous sedation. Although there have been many researches on the effects of midazolam and propofol on vital function and the recovery profile, little is known about muscle power. This review discusses the effects of intravenous sedation using midazolam and propofol on both grip strength and bite force...
November 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29201256/neuropeptides-and-atp-signaling-in-the-trigeminal-ganglion
#15
REVIEW
Tetsuya Goto, Haruki Iwai, Eriko Kuramoto, Atsushi Yamanaka
Peripheral nociceptive stimuli from orofacial structures are largely transmitted by the trigeminal nerve. According to the peripheral noxious stimuli, neurons in the trigeminal ganglion (TG) produce neuropeptides such as substance P, and calcitonin-gene-related peptide, etc. Beside the production of neuropeptides, there exists unique non-synaptic interaction system between maxillary and mandibular neurons in the TG. Neurons in the TG are surrounded by satellite glial cells (SGCs), which initially receive the signal from TG neurons...
November 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29201255/english-education-for-healthcare-professionals-in-japan
#16
REVIEW
Janelle Moross, Naoko Seki, Ikuko Morio
In a global environment, education for healthcare professionals should include cultivating human resources who have the necessary skills to work in an international arena. This article will review the current status of English education for dental healthcare professionals in Japan. After conducting a literature search using the keywords: English education, Japan, and dental, only a few studies were found that investigated and proposed suggestions for dental professional English education. Even so, these were still in the early stages with outcomes yet to be fully evaluated...
November 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28725300/epstein-barr-virus-ebv-associated-epithelial-and-non-epithelial-lesions-of-the-oral-cavity
#17
REVIEW
Kentaro Kikuchi, Harumi Inoue, Yuji Miyazaki, Fumio Ide, Masaru Kojima, Kaoru Kusama
Epstein-Barr virus (EBV) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (LPDs) in immunocompromised patients. EBV, a B-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. Furthermore, EBV is associated with epithelial malignancies such as nasopharyngeal carcinoma (NPC), salivary gland tumor, gastric carcinoma and breast carcinoma. In terms of oral disease, there have been several reports of EBV-related oral squamous cell carcinoma (OSCC) worldwide...
August 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28725299/role-of-streptococcus-mutans-two-component-systems-in-antimicrobial-peptide-resistance-in-the-oral-cavity
#18
REVIEW
Miki Kawada-Matsuo, Hitoshi Komatsuzawa
Approximately 100 trillion microorganisms exist in the oral cavity. For the commensal bacteria of the oral cavity, it is important to adapt to environmental stimuli, including human- or bacteria-derived antimicrobial agents. Recently, bacterial-specific signal transduction regulatory systems, called two-component systems (TCSs), which appear to be focused on sensing and adapting to the environment, were discovered. Streptococcus mutans is an oral commensal bacteria and is also known as a cariogenic bacteria...
August 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28725298/thirst-sensation-and-oral-dryness-following-alcohol-intake
#19
REVIEW
Kiyotoshi Inenaga, Kentaro Ono, Suzuro Hitomi, Ayu Kuroki, Izumi Ujihara
Substantial acute and chronic intakes of alcohol or ethanol (EtOH) severely influence oral sensations, such as thirst and oral dryness (dry mouth, xerostomia). Thirst sensation and oral dryness are primarily caused by the activation of neurons in brain regions, including the circumventricular organs and hypothalamus, which are referred to as the dipsogenic center, and by a decrease in salivary secretion, respectively. The sensation of thirst experienced after heavy-alcohol drinking is widely regarded as a consequence of EtOH-induced diuresis; however, EtOH in high doses induces anti-diuresis...
August 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28725297/therapeutic-strategies-with-oral-fluoropyrimidine-anticancer-agent-s-1-against-oral-cancer
#20
REVIEW
Koji Harada, Tarannum Ferdous, Yoshiya Ueyama
Oral cancer has been recognized as a tumor with low sensitivity to anticancer agents. However, introduction of S-1, an oral cancer agent is improving treatment outcome for patients with oral cancer. In addition, S-1, as a main drug for oral cancer treatment in Japan can be easily available for outpatients. In fact, S-1 exerts high therapeutic effects with acceptable side effects. Moreover, combined chemotherapy with S-1 shows higher efficacy than S-1 alone, and combined chemo-radiotherapy with S-1 exerts remarkable therapeutic effects...
August 2017: Japanese Dental Science Review
journal
journal
42126
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"