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World Allergy Organization Journal

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https://www.readbyqxmd.com/read/30534341/test-for-respiratory-and-asthma-control-in-kids-track-validation-of-the-portuguese-version
#1
Gustavo F Wandalsen, Renata G Dias, Herberto J Chong-Neto, Nelson Rosário, Lillian Moraes, Neusa F Wandalsen, Décio Medeiros, Ana Caroline Della Bianca, Marilyn Urrutia-Pereira, Jennifer Avila, Patrícia P Jorge, Dirceu Solé
Background: TRACK (Test for Respiratory and Asthma Control in Kids) questionnaire is an instrument developed and validated in English to evaluate the control of respiratory symptoms in children under 5 years of age. Objective: To validate the Portuguese version of the TRACK questionnaire. Methods: The validation was done in an observational, prospective and multicenter evaluation (six centers in Brazil) in children with recurrent respiratory symptoms...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30534340/comparison-of-microbiota-and-allergen-profile-in-house-dust-from-homes-of-allergic-and-non-allergic-subjects-results-from-the-gusto-study
#2
Evelyn Xiu Ling Loo, Lamony Jian Ming Chew, Atiqa Binte Zulkifli, Le Duc Huy Ta, I-Chun Kuo, Anne Goh, Oon Hoe Teoh, Hugo Van Bever, Peter D Gluckman, Fabian Yap, Kok Hian Tan, Yap Seng Chong, Bee Wah Lee, Lynette Pei-Chi Shek
Background: The prevalence of allergic diseases, such as asthma, allergic rhinitis, eczema and food allergy, has been increasing worldwide, as shown in a large number of studies, including the International Study of Asthma and Allergies in Childhood (ISAAC). However, there is significant variation in the prevalence of these diseases in different regions, suggesting that there may be location-specific factors such as environment and microbial exposure affecting allergic disease prevalence...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30524647/omalizumab-in-the-treatment-of-eosinophilic-granulomatosis-with-polyangiitis-egpa-single-center-experience-in-18-cases
#3
Zeynep Celebi Sozener, Begum Gorgulu, Dilsad Mungan, Betul Ayse Sin, Zeynep Misirligil, Omur Aydin, Sevim Bavbek
Background: Data are limited regarding the effectiveness of omalizumab in patients with eosinophilic granulomatosis with polyangiitis (EGPA). Our aim was to evaluate the clinical and functional effectiveness of omalizumab in patients with EGPA in long-term follow-up. Methods: This study was a retrospective chart review of patients with EGPA who were treated with omalizumab injections between May 2012 and April 2018. Once treatment with omalizumab was started, data were collected at various time points: baseline, the 16th week, 1st year, and annually until the last evaluation...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30524646/allergen-specific-ige-and-igg4-patterns-among-patients-with-different-allergic-diseases
#4
Olga Smoldovskaya, Guzel Feyzkhanova, Sergei Voloshin, Alla Arefieva, Antonina Chubarova, Ludmila Pavlushkina, Tatiana Filatova, Eugenia Antonova, Elena Timofeeva, Veronika Butvilovskaya, Yuri Lysov, Alexander Zasedatelev, Alla Rubina
Background: In addition to allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and sIgG4 patterns in the most common allergic disorders: bronchial asthma, upper airway disorders and atopic dermatitis. Methods: In this study a screening analysis of blood serum samples from 673 patients aged from 6 months to 17 years with different allergic entities was performed on microarrays...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30524645/intake-of-a-fermented-plant-product-attenuates-allergic-symptoms-without-changing-systemic-immune-responses-in-a-mouse-model-of-japanese-cedar-pollinosis
#5
Takashi Fujimura, Ayane Hori, Hideto Torii, Shinsuke Kishida, Yoshinori Matsuura, Seiji Kawamoto
Background: Japanese cedar pollinosis (JCP) is one of the most prevalent allergies in Japan. Within the past few decades, many food factors have been demonstrated to suppress symptoms of pollinosis and mast cell degranulation directly or indirectly. Herein, we conducted a study to clarify the anti-allergic potency of a fermented plant product (FPP) in JCP model mice. Methods: Mice were administered FPP, 10-fold-diluted FPP, or saline every day for 40 days by oral gavage and sensitized with major Japanese cedar pollen allergens (SBP)...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30524644/impact-of-a-digital-health-intervention-on-asthma-resource-utilization
#6
Rajan Merchant, Stanley J Szefler, Bruce G Bender, Michael Tuffli, Meredith A Barrett, Rahul Gondalia, Leanne Kaye, David Van Sickle, David A Stempel
Digital health interventions have been associated with reduced rescue inhaler use and improved controller medication adherence. This quality improvement project assessed the benefit of these interventions on asthma-related healthcare utilizations, including hospitalizations, emergency department (ED) utilization and outpatient visits. The intervention consisted of electronic medication monitors (EMMs) that tracked rescue and controller inhaler medication use, and a digital health platform that presented medication use information and asthma control status to patients and providers...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30473740/prevalence-and-treatment-of-allergies-in-rural-areas-of-bavaria-germany-a-cross-sectional-study
#7
REVIEW
Danielle Boehmer, Barbara Schuster, Julia Krause, Ulf Darsow, Tilo Biedermann, Alexander Zink
Background: There is a high prevalence of allergies in Germany, with approximately 20% of the population having at least one allergy and only about 10% of these being treated adequately. We conducted a cross-sectional study in a rural area of Bavaria (Southern Germany) to evaluate the prevalence of allergies and their treatment, because research regarding this topic is currently limited. Methods: Data were collected in 10 offices of non-dermatological doctors using a self-filled questionnaire to ask participants about allergies and treatment...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30464782/differences-in-chronic-spontaneous-urticaria-between-europe-and-central-south-america-results-of-the-multi-center-real-world-aware-study
#8
M Maurer, K Houghton, C Costa, F Dabove, L F Ensina, A Giménez-Arnau, G Guillet, G N Konstantinou, M Labrador-Horrillo, H Lapeere, R Meshkova, E A Pastorello, M Velásquez-Lopera, L M Tamayo Quijano, C Vestergaard, N Chapman-Rothe
Background: Global chronic urticaria (CU) disease experience and management is not well documented. This study descriptively compares these aspects among CU patients residing in Europe (EU) and Central and South America (C/SA). Methods: AWARE (A World-wide Antihistamine-Refractory chronic urticaria patient Evaluation) is a global prospective, non-interventional study of CU in the real-world setting. Patients were ≥ 18 years with a diagnosis of H1-antihistamine-refractory CU for > 2 months...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30459928/confounders-of-severe-asthma-diagnoses-to-consider-when-asthma-symptoms-persist-despite-optimal-therapy
#9
REVIEW
Alina Gherasim, Ahn Dao, Jonathan A Bernstein
Asthma can often be challenging to diagnose especially when patients present with atypical symptoms. Therefore, it is important to have a broad differential diagnosis for asthma to ensure that other conditions are not missed. Clinicians must maintain a high index of suspicion for asthma mimickers, especially when patients fail to respond to conventional therapy. The purpose of this review is to briefly review some of the more common causes of asthma mimickers that clinicians should consider when the diagnosis of asthma is unclear...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30459927/health-care-costs-and-resource-utilization-for-different-asthma-severity-stages-in-colombia-a-claims-data-analysis
#10
Álvaro Flórez-Tanus, Devian Parra, Josefina Zakzuk, Luis Caraballo, Nelson Alvis-Guzmán
Background: Asthma is one of the most common chronic respiratory conditions worldwide. Asthma-related economic burden has been reported in Latin America, but knowledge about its economic impact to the Colombian health care system and the influence of disease severity is lacking. This study estimated direct medical costs and health care resource utilization (HCRU) in patients with asthma according to severity in Colombia. Methods: This study identified all-age patients who had at least one medical event linked to an asthma diagnosis (CIE-10: J45-J46) between 2004 and 2014...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30425779/probiotics-as-treatment-for-food-allergies-among-pediatric-patients-a-meta-analysis
#11
Carol Stephanie C Tan-Lim, Natasha Ann R Esteban-Ipac
Background: The burden of disease of food allergy is increasing worldwide. The standard of management is allergen avoidance and symptomatic treatment. Probiotics have been proposed to be beneficial for treatment and prevention of food allergy. Objective: To determine the effectiveness of probiotic administration in treating food allergies among pediatric patients. Methods: A systematic search of electronic medical literature databases was conducted...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30410639/improvement-of-patient-reported-outcomes-in-severe-allergic-asthma-by-omalizumab-treatment-the-real-life-observational-proxima-study
#12
Giorgio Walter Canonica, Paola Rottoli, Caterina Bucca, Maria Cristina Zappa, Giovanni Michetti, Bruno Macciocchi, Cristiano Caruso, Pierachille Santus, Marta Bartezaghi, Laura Rigoni
Background: Data on the prevalence of perennial versus seasonal allergic asthma in Italy are lacking; moreover, there is limited evidence on the effect of omalizumab on patient-reported outcomes in Italian patients with severe allergic asthma. PROXIMA, an observational, multicenter study, was designed to assess the prevalence of perennial versus seasonal allergic asthma (cross-sectional phase) and the effect of omalizumab on improving illness perception, quality of life (QoL) and asthma control of Italian patients with severe allergic asthma (longitudinal phase)...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30386455/potential-new-targets-for-drug-development-in-severe-asthma
#13
REVIEW
Linda Zhu, Christina E Ciaccio, Thomas B Casale
In recent years there has been increasing recognition of varying asthma phenotypes that impact treatment response. This has led to the development of biological therapies targeting specific immune cells and cytokines in the inflammatory cascade. Currently, there are two primary asthma phenotypes, Type 2 hi and Type 2 lo, which are defined by eosinophilic and neutrophilic/pauci- granulocytic pattern of inflammation respectively. Most biologics focus on Type 2 hi asthma, including all four biologics approved for treatment of uncontrolled asthma in the United States - omalizumab, mepolizumab, reslizumab, and benralizumab...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30386454/brazilian-experience-with-atopy-patch-tests-for-dermatophagoides-pteronyssinus-dermatophagoides-farinae-and-blomia-tropicalis
#14
Ingrid Pimentel Cunha Magalhães de Souza Lima, Beatriz Julião Aarestrup, Eduardo Magalhães de Souza Lima, Marina Cunha de Souza Lima, Eduardo Cunha de Souza Lima, Fernando Monteiro Aarestrup
Background: The aim of this study was to evaluate the positivity rates of atopy patch tests for Dermatophagoides pteronyssinus , Dermatophagoides farinae and Blomia tropicalis in patients with respiratory diseases such as asthma and allergic rhinitis with or without atopic dermatitis. Methods: The patients' clinical histories were collected, and the patients were subjected to skin prick and patch tests with the three different house dust mites on the same day. The patch tests were examined 48 hours later, and then patients were divided into two groups: I- patients with respiratory diseases, such as asthma and/or rhinitis, and atopic dermatitis and II-patients with only respiratory diseases...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30349618/the-connection-of-pollen-concentrations-and-crowd-sourced-symptom-data-new-insights-from-daily-and-seasonal-symptom-load-index-data-from-2013-to-2017-in-vienna
#15
Katharina Bastl, Maximilian Kmenta, Markus Berger, Uwe Berger
Background: Online pollen diaries and mobile applications nowadays allow easy and fast documentation of pollen allergy symptoms. Such crowd-sourced symptom data provides insights into the development and the onset of a pollen allergy. Hitherto studies of the symptom load index (SLI) showed a discrepancy between the SLI and the total pollen amount of a season, but did not analyze the daily data. Methods: The Patient's Hayfever Diary (PHD) was used as data pool for symptom data...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30349617/increasing-trends-of-anaphylaxis-related-events-an-analysis-of-anaphylaxis-using-nationwide-data-in-taiwan-2001-2013
#16
Tsung-Chieh Yao, Ann Chen Wu, Ya-Wen Huang, Jiu-Yao Wang, Hui-Ju Tsai
Background: Anaphylaxis is a severe, potentially fatal, and systemic allergic reaction. Previous studies document increasing trends in incidence rates of anaphylaxis-related events in Western countries, yet little is known about the incidence and trend of anaphylaxis in Asia. In this study, we aimed to determine time trends in incidence rates of anaphylaxis-related events in Taiwan from 2001 through 2013. Methods: We utilized medical claims data from the National Health Insurance Research Databases in Taiwan...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30323863/clinical-efficacy-of-sublingual-immunotherapy-is-associated-with-restoration-of-steady-state-serum-lipocalin-2-after-slit-a-pilot-study
#17
Franziska Roth-Walter, René Schmutz, Nadine Mothes-Luksch, Patrick Lemell, Petra Zieglmayer, René Zieglmayer, Erika Jensen-Jarolim
Background: So far, only a few biomarkers in allergen immunotherapy exist that are associated with a clinical benefit. We thus investigated in a pilot study whether innate molecules such as the molecule lipocalin-2 (LCN2), with implications in immune tolerance demonstrated in other fields, may discriminate A) between allergic and non-allergic individuals, and B) between patients clinically responding or non-responding to sublingual allergen immunotherapy (SLIT) with house dust mite (HDM) extract...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30214659/allergy-diagnosis-from-symptoms-to-molecules-or-from-molecules-to-symptoms-a-comparative-clinical-study
#18
N Mothes-Luksch, G Jordakieva, L Hinterhölzl, A N Jensen, P K Hallmann, M Kundi, E Jensen-Jarolim
Background: Classical allergy diagnostic workup "from symptoms to molecules" comprises 1) clinical investigation, 2) skin prick- and IgE- testing, and recently, 3) molecular allergy testing. We aimed to examine the diagnostic fidelity of the alternative approach "from molecules to symptoms", which was recently suggested in the EAACI Molecular Allergology User's Guide, in a retrospective clinical study. Methods: Records from 202 patients with clinically suspected allergic sensitizations were extracted from files at two sites applying either the "ISAC-first" workup with IgE-testing by immuno-solid phase allergen chip ISAC112 followed by selected skin prick tests (SPT) or the "SPT-first" starting with SPT followed by the microarray test...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30214658/anaphylaxis-triggers-in-a-large-tertiary-care-hospital-in-qatar-a-retrospective-study
#19
Taghreed Abunada, Maryam Ali Al-Nesf, Lukman Thalib, Rana Kurdi, Sally Khalil, Wessam ElKassem, Hassan M Mobayed, Hatem Zayed
Background: Anaphylaxis is a serious allergic disease that may lead to death if not immediately recognized and treated. Triggers of anaphylaxis including food, drugs, and insect stings can vary widely. The incidence of anaphylaxis seems to be affected by age, sex, atopy, and geographic location. This study aims to examine the common triggers of anaphylaxis in Qatar. Methods: A total of 1068 electronic medical records were audited using power chart system: 446 from the medical coding system of anaphylaxis and 622 from the epinephrine auto-injectors (EAIs) dispensed during January 2012-December 2017...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/30128065/the-impact-of-allergen-exposure-and-specific-immunotherapy-on-circulating-blood-cells-in-allergic-rhinitis
#20
REVIEW
Galateja Jordakieva, Erika Jensen-Jarolim
Allergic rhinitis (AR) is an IgE-mediated inflammatory disease of the nasal mucosa with well described local immune responses during allergen exposure. The frequent association of AR with general extra-nasal symptoms and other allergic conditions, such as conjunctivitis and asthma, however, support a more systemic disease impact. In addition to acute elevation of soluble inflammatory mediators in periphery blood, a growing number of studies have reported changes in circulating blood cells after specific nasal allergen challenge or environmental allergen exposure...
2018: World Allergy Organization Journal
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