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World Allergy Organization Journal

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https://www.readbyqxmd.com/read/29043012/checklist-for-a-complete-chronic-urticaria-medical-history-an-easy-tool
#1
Ivan Cherrez-Ojeda, Karla Robles-Velasco, Pamela Bedoya-Riofrío, Peter Schmid-Grendelmeier, Sofía Cherrez, Florian Colbatzky, Ricardo Cardona, Pedro Barberan-Torres, Erick Calero, Annia Cherrez
BACKGROUND: Existing guidelines do not offer a quick, efficient alternative to the patient's recollection of relevant clinical features during anamnesis and physical examination for chronic urticaria (CU). This study aimed to identify specific items reflecting the main characteristics of CU that should be included in a comprehensive medical history for patients with CU. We also aimed to clarify possible eliciting factors for CU to support accurate diagnosis of the disease. METHODS: A panel of postgraduate dermatologists conducted a literature search for relevant studies on CU using Medline, the Cochrane database, and PubMed...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29043011/debates-in-allergy-medicine-allergy-skin-testing-cannot-be-replaced-by-molecular-diagnosis-in-the-near-future
#2
Désirée Larenas-Linnemann, Jorge A Luna-Pech, Ralph Mösges
Percutaneous skin prick tests (SPT) have been considered the preferred method for confirming IgE-mediated sensitization. This reliable and minimally invasive technique correlates with in vivo challenges, has good reproducibility, is easily quantified, and allows analyzing multiple allergens simultaneously. Potent extracts and a proficient tester improve its accuracy. Molecular-based allergy diagnostics (MA-Dx) quantifies allergenic components obtained either from purification of natural sources or recombinant technology to identify the patient's reactivity to those specific allergenic protein components...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28959378/debates-in-allergy-medicine-molecular-allergy-diagnosis-with-isac-will-replace-screenings-by-skin-prick-test-in-the-future
#3
E Jensen-Jarolim, A N Jensen, G W Canonica
In today's clinical practice patients' skin is used as screening organ for diagnosing type 1 allergy. According to European guidelines skin prick testing with a panel of 18 allergen extracts is recommended, in the US between 10 to 50 allergens are used. The specificity and sensitivity of skin testing is individually highly variable depending on age, body mass, and skin barrier status. In atopic inflammation skin testing gives more false positive results. Smaller skin area and strain limits prick testing in small children...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28932345/the-grass-pollen-season-2015-a-proof-of-concept-multi-approach-study-in-three-different-european-cities
#4
Maximilian Kmenta, Katharina Bastl, Uwe Berger, Matthias F Kramer, Matthew D Heath, Sanna Pätsi, Anna-Mari Pessi, Annika Saarto, Barbora Werchan, Matthias Werchan, Reinhard Zetter, Karl-Christian Bergmann
BACKGROUND: Grasses release the most widespread aeroallergens with considerable sensitization rates, while different species produce several pollen concentration peaks throughout the season. This study analyzed the prevalence of grass species in three different European city areas and compared the flowering period of these species with daily pollen concentrations and the symptom loads of grass pollen allergy sufferers. METHODS: The most prevalent grass species in Vienna (Austria), Berlin (Germany) and Turku (Finland) were studied and examined by use of three different approaches: phenology, pollen monitoring and symptom load evaluation...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28904734/a-17-year-old-male-with-a-small-bowel-neuroendocrine-tumor-flushing-differential-diagnosis
#5
Maria Alejandra Forero Molina, Elizabeth Garcia, Deyanira Gonzalez-Devia, Rafael García-Duperly, Alonso Vera
BACKGROUND: Neuroendocrine tumors (NETs) are heterogeneous neoplasms that originate from cells with a secretory function. Small bowel NETs (SB-NETs) are related to serotonin hypersecretion which causes: flushing, diarrhea, abdominal pain, bronchoconstriction and heart involvement, also known as carcinoid syndrome (CS). CS can be confused with an allergic reaction and thus should be considered as a differential diagnosis in the allergy consult. We present the case of a pediatric patient initially referred under the suspicion of food allergies...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28855974/the-skin-microbiome-impact-of-modern-environments-on-skin-ecology-barrier-integrity-and-systemic-immune-programming
#6
REVIEW
Susan L Prescott, Danica-Lea Larcombe, Alan C Logan, Christina West, Wesley Burks, Luis Caraballo, Michael Levin, Eddie Van Etten, Pierre Horwitz, Anita Kozyrskyj, Dianne E Campbell
Skin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28855973/severe-asthma-and-quality-of-life
#7
REVIEW
Elham Hossny, Luis Caraballo, Thomas Casale, Yehia El-Gamal, Lanny Rosenwasser
Severe asthma has a great impact on the quality of life (QOL) of patients and their families. The magnitude of this morbidity is affected by several personal factors including age. Appropriate asthma control and modifications of social roles and activities are expected to improve QOL. Biologics, primarily monoclonal antibodies, have been developed to target specific pathways and molecules important in the pathogenesis of asthma. The use of biologics has shown some promising effects on the QOL of patients with severe recalcitrant asthma...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28811862/allergic-profiles-of-mothers-and-fathers-in-the-japan-environment-and-children-s-study-jecs-a-nationwide-birth-cohort-study
#8
Kiwako Yamamoto-Hanada, Limin Yang, Kazue Ishitsuka, Tadayuki Ayabe, Hidetoshi Mezawa, Mizuho Konishi, Testsuo Shoda, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
BACKGROUND: The Japan Environment and Children's Study (JECS) is a nationwide, multicenter, prospective birth cohort investigation launched by the Ministry of Environment in Japan. The purpose of the JECS is to evaluate the influence of prenatal and postnatal exposures to environmental factors on the postnatal health of the children. In this study, we evaluated the allergic characteristics of parents within the JECS cohort. METHODS: This study covered a wide geographical area and encompassed 15 regional centers...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28781718/a-partially-hydrolyzed-100-whey-formula-and-the-risk-of-eczema-and-any-allergy-an-updated-meta-analysis
#9
REVIEW
Hania Szajewska, Andrea Horvath
BACKGROUND: Recently, the role of using hydrolyzed formula for the prevention of allergic disease has been questioned. However, not all hydrolyzed formulas are equal. The efficacy of each hydrolyzed formula should be established separately. We updated evidence on the effectiveness of using partially hydrolyzed 100% whey formula (pHF), manufactured by a single manufacturer, for reducing the risk of eczema and allergy in healthy infants at high risk for allergy. METHODS: The Cochrane Library, MEDLINE, and EMBASE databases were searched in June 2016 for randomized and quasi-randomized controlled trials (RCTs); additional data were obtained from reviewed articles and the authors of included trials...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28725335/is-peanut-causing-food-allergy-in-cuba-preliminary-assessment-of-allergic-sensitization-and-ige-specificity-profile-to-peanut-allergens-in-cuban-allergic-patients
#10
Mayteé Mateo-Morejón, Alexis Labrada-Rosado, Damaris Torralba-Averoff, Rayza Cruz-Jimenez, Yunia Oliva-Díaz, Mirta Álvarez-Castelló, Alexander Ciria-Martín, Marlene Jiménez-Frandín, Mary Carmen Reyes-Zamora, Raúl Lázaro Castro-Almarales, Beatriz Tamargo-García
BACKGROUND: Peanut allergy is increasing at an alarming pace in developed countries. Peanut (Arachis hypogaea) is a common food in Cuba. Nevertheless, reported values of sensitization and symptom severity are usually low. As our objective, we carried out an evaluation of allergic sensitivity to perform an assessment of allergic sensitization and IgE specificity profile to peanut allergens in Cuban allergic patients. METHODS: The Skin Prick Test (SPT) was performed for each patient, using two glycerinated allergenic extracts, prepared from raw or roasted peanuts...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28702111/innate-function-of-house-dust-mite-allergens-robust-enzymatic-degradation-of-extracellular-matrix-at-elevated-ph
#11
Kumiko Oida, Lukas Einhorn, Ina Herrmann, Lucia Panakova, Yvonne Resch, Susanne Vrtala, Gerlinde Hofstetter, Akane Tanaka, Hiroshi Matsuda, Erika Jensen-Jarolim
BACKGROUND: Exposure to the house dust mite Dermatophagoides pteronyssinus (D.p.) increases the risk for developing allergic diseases in humans and their best friends, the dogs. Here, we explored whether this allergenic mite via its enzymes may impact the cutaneous extracellular matrix (ECM), which critically determines epithelial barrier integrity both structurally and functionally. METHODS: Two extracts obtained from either dust-purified or cultured D.p. bodies were used in the present study...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28649294/randomised-controlled-trial-of-a-baked-egg-intervention-in-young-children-allergic-to-raw-egg-but-not-baked-egg
#12
Merryn Netting, Michael Gold, Patrick Quinn, Adaweyah El-Merhibi, Irmeli Penttila, Maria Makrides
BACKGROUND: Consumption of baked egg by raw egg allergic children is associated with immune changes suggesting development of tolerance. However, causation has not been tested using a double blind randomized controlled trial (RCT). We aimed to compare clinical and immunological outcomes after baked egg (BE) consumption in young BE tolerant egg allergic children. METHODS: In a double blind RCT, BE tolerant egg allergic children consumed 10 g BE (1.3 g protein) 2 to 3 times per week for 6 months (n = 21 intervention group) or similar egg free baked goods (n = 22 control group) while maintaining an otherwise egg free diet...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28649293/small-airways-disease-and-severe-asthma
#13
REVIEW
Tara F Carr, Roula Altisheh, Myron Zitt
The small airways of the lungs are commonly affected in pediatric and adult asthma. Small airways disease has been related to asthma control, severity, and risk of exacerbation. Diagnosis of small airways disease can be best made through evaluation of surgical lung specimens. Noninvasive techniques including spirometry, plethysmography, nitrogen washout, impulse oscillometry, and cross-sectional imaging have been utilized to assess and infer the extent of small airways disease in asthma and can be used longitudinally to assess response to treatment...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28616124/psychoneuroimmunoendocrinology-clinical-implications
#14
REVIEW
Sandra Nora González-Díaz, Alfredo Arias-Cruz, Bárbara Elizondo-Villarreal, Olga Patricia Monge-Ortega
Psychoneuroimmunoendocrinology, which was first described in 1936, is the study of the interactions between the psyche, neural and endocrine functions and immune responses. The aim of psychoneuroimmunoendocrinology is to apply medical knowledge to the treatment of different allergic, immune, autoimmune, rheumatic, neoplastic, endocrine, cardiovascular and dental pathologies, among other disorders. Epigenetic factors and major stresses from different types of stimuli acting through distinct pathways and neurotransmitters are highly involved in altering the psychoneuroimmunoendocrine axis, resulting in the emergence of disease...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28546850/knowledge-and-management-of-chronic-spontaneous-urticaria-in-latin-america-a-cross-sectional-study-in-ecuador
#15
A Cherrez, M Maurer, K Weller, J C Calderon, D Simancas-Racines, I Cherrez Ojeda
BACKGROUND: The current EAACI/GA(2)LEN/EDF/WAO guideline for urticaria provide specific recommendations for the diagnostic workup and treatment of patients with chronic spontaneous urticaria (CsU). This study explored if physicians in Ecuador know these recommendations and implement them in their actual clinical practice for CsU. METHODS: We investigated physicians who treat CsU patients in a cross-sectional study using a standardized questionnaire. Descriptive statistics were employed, adjusted logistic regression was performed to assess the link of guideline knowledge and use of therapy...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28546849/why-a-registry-of-chronic-urticaria-cur-is-needed
#16
R M Gómez, E Jares, G W Canonica, I Baiardini, G Passalacqua, M Sánchez Borges, A P Kaplan, Carlos E Baena-Cagnani
Chronic urticaria (CU) has a major effect on patients' quality of life. While there have been progressive advances regarding its pathogenesis and treatment, much remains to be done. Registries of other chronic non-communicable diseases have shown many benefits, such as additional basic knowledge and management approaches to diabetes mellitus. Standards of care as well as diagnostic approaches can be elaborated and compared from different sites, using validated instruments. Registries in allergic diseases are also becoming well recognized, and the first registry on CU, accessible from SLaai's webpage, includes parameters for identification, evaluation and management...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28496564/in-flight-allergic-emergencies
#17
REVIEW
Mario Sánchez-Borges, Victoria Cardona, Margitta Worm, Richard F Lockey, Aziz Sheikh, Paul A Greenberger, Ignacio J Ansotegui, Motohiro Ebisawa, Yehia El-Gamal, Stanley Fineman, Mario Geller, Alexei Gonzalez-Estrada, Luciana Tanno, Bernard Y Thong
Allergic and hypersensitivity reactions such as anaphylaxis and asthma exacerbations may occur during air travel. Although the exact incidence of in-flight asthma and allergic emergencies is not known, we have concerns that this subject has not received the attention it warrants. There is a need to provide passengers at risk and airlines with the necessary measures to prevent and manage these emergencies. A review of the epidemiology, management and approaches to prevention of allergic and asthma emergencies during air travel is presented with the goal of increasing awareness about these important, potentially preventable medical events...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28469764/re-international-survey-on-skin-patch-test-procedures-attitudes-and-interpretation-l-k-tanno-et-al-waoj-2016-9-8
#18
Wolfgang Uter, Magnus Bruze, Thomas Rustemeyer, David Orton, Vera Mahler
A previous survey on the practice of diagnostic patch testing among representatives of member societies of the World Allergy Organization (WAO) has, in some countries, not addressed those stakeholders actually involved in patch testing, mainly dermatologists. The need for further standardisation is acknowledged and has been addressed e.g. by publication of a patch test guideline by the European Society of Contact Dermatitis in October 2015.
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28451054/molecular-fingerprinting-of-complex-grass-allergoids-size-assessments-reveal-new-insights-in-epitope-repertoires-and-functional-capacities
#19
S Starchenka, A J Bell, J Mwange, M A Skinner, M D Heath
BACKGROUND: Subcutaneous allergen immunotherapy (SCIT) is a well-documented treatment for allergic disease which involves injections of native allergen or modified (allergoid) extracts. The use of allergoid vaccines is a growing sector of the allergy immunotherapy market, associated with shorter-course therapy. The aim of this study was the structural and immunological characterisation of group 1 (Lol p 1) IgG-binding epitopes within a complex mix grass allergoid formulation containing rye grass...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28451053/international-consensus-icon-on-clinical-consequences-of-mite-hypersensitivity-a-global-problem
#20
Mario Sánchez-Borges, Enrique Fernandez-Caldas, Wayne R Thomas, Martin D Chapman, Bee Wah Lee, Luis Caraballo, Nathalie Acevedo, Fook Tim Chew, Ignacio J Ansotegui, Leili Behrooz, Wanda Phipatanakul, Roy Gerth van Wijk, Demoly Pascal, Nelson Rosario, Motohiro Ebisawa, Mario Geller, Santiago Quirce, Susanne Vrtala, Rudolf Valenta, Markus Ollert, Giorgio Walter Canonica, Moises A Calderón, Charles S Barnes, Adnan Custovic, Suwat Benjaponpitak, Arnaldo Capriles-Hulett
Since mite allergens are the most relevant inducers of allergic diseases worldwide, resulting in significant morbidity and increased burden on health services, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), formed by the American Academy of Allergy, Asthma and Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI), the European Academy of Allergy and Clinical Immunology (EAACI), and the World Allergy Organization (WAO), has proposed to issue an International Consensus (ICON) on the clinical consequences of mite hypersensitivity...
2017: World Allergy Organization Journal
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