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World Allergy Organization Journal

Franziska Roth-Walter, René Schmutz, Nadine Mothes-Luksch, Patrick Lemell, Petra Zieglmayer, René Zieglmayer, Erika Jensen-Jarolim
Background: So far, only a few biomarkers in allergen immunotherapy exist that are associated with a clinical benefit. We thus investigated in a pilot study whether innate molecules such as the molecule lipocalin-2 (LCN2), with implications in immune tolerance demonstrated in other fields, may discriminate A) between allergic and non-allergic individuals, and B) between patients clinically responding or non-responding to sublingual allergen immunotherapy (SLIT) with house dust mite (HDM) extract...
2018: World Allergy Organization Journal
N Mothes-Luksch, G Jordakieva, L Hinterhölzl, A N Jensen, P K Hallmann, M Kundi, E Jensen-Jarolim
Background: Classical allergy diagnostic workup "from symptoms to molecules" comprises 1) clinical investigation, 2) skin prick- and IgE- testing, and recently, 3) molecular allergy testing. We aimed to examine the diagnostic fidelity of the alternative approach "from molecules to symptoms", which was recently suggested in the EAACI Molecular Allergology User's Guide, in a retrospective clinical study. Methods: Records from 202 patients with clinically suspected allergic sensitizations were extracted from files at two sites applying either the "ISAC-first" workup with IgE-testing by immuno-solid phase allergen chip ISAC112 followed by selected skin prick tests (SPT) or the "SPT-first" starting with SPT followed by the microarray test...
2018: World Allergy Organization Journal
Taghreed Abunada, Maryam Ali Al-Nesf, Lukman Thalib, Rana Kurdi, Sally Khalil, Wessam ElKassem, Hassan M Mobayed, Hatem Zayed
Background: Anaphylaxis is a serious allergic disease that may lead to death if not immediately recognized and treated. Triggers of anaphylaxis including food, drugs, and insect stings can vary widely. The incidence of anaphylaxis seems to be affected by age, sex, atopy, and geographic location. This study aims to examine the common triggers of anaphylaxis in Qatar. Methods: A total of 1068 electronic medical records were audited using power chart system: 446 from the medical coding system of anaphylaxis and 622 from the epinephrine auto-injectors (EAIs) dispensed during January 2012-December 2017...
2018: World Allergy Organization Journal
Galateja Jordakieva, Erika Jensen-Jarolim
Allergic rhinitis (AR) is an IgE-mediated inflammatory disease of the nasal mucosa with well described local immune responses during allergen exposure. The frequent association of AR with general extra-nasal symptoms and other allergic conditions, such as conjunctivitis and asthma, however, support a more systemic disease impact. In addition to acute elevation of soluble inflammatory mediators in periphery blood, a growing number of studies have reported changes in circulating blood cells after specific nasal allergen challenge or environmental allergen exposure...
2018: World Allergy Organization Journal
Zelalem Tilahun Tesfaye, Nebeyu Tsegu Gebreselase, Boressa Adugna Horsa
Background: Although asthma cannot be cured, appropriate management can ensure adequate control of the disease, prevent disease progression and even reverse the illness, enabling people to enjoy good quality of life. Predisposing factors for inappropriate asthma management, including limited diagnostic options and inadequate supply of medications, are features of health institutions in developing countries like Ethiopia. This study was launched to determine the appropriateness of asthma management in patients visiting ambulatory clinic of the Gondar University Hospital...
2018: World Allergy Organization Journal
Sher Ney Chong, Fook Tim Chew
This review article aims to present the epidemiology and associated risk factors of allergic rhinitis (AR) in Asia. AR-related literature published on Asia was systematically reviewed and the associated risk factors were investigated. The prevalence of AR in Asia varied considerably depending on the geographical location, study design and population involved. Several risk factors were observed to have strong association with disease presentation across multiple studies. Among these, family income, family size, daily personal computer usage time, personal and parental education attainment, and stress level have shown some level of biological gradient influence when multiple risk levels were analyzed...
2018: World Allergy Organization Journal
Thu T K Le, Thuy T B Tran, Huong T M Ho, An T L Vu, Andreas L Lopata
Background: Web-based surveys (WBS) are increasingly applied in epidemiological studies as an appealing alternative to traditional survey methods. Rapid data collection, reduced expenditure and ease of access to large populations are some of the clear advantages of online surveys. However, WBS are still subject to limitations in terms of sample size, response rate and other additional biases compared to traditional survey methods. In the present study, we seek to validate data on food allergy (FA) in two independent sample populations collected from a WBS, and compare it to a paper-based survey (PBS)...
2018: World Allergy Organization Journal
D Samreth, S Arnavielhe, F Ingenrieth, A Bedbrook, G L Onorato, R Murray, R Almeida, M A Mizani, J Fonseca, E Costa, J Malva, M Morais-Almeida, A M Pereira, A Todo-Bom, E Menditto, C Stellato, M T Ventura, D Larenas-Linnemann, J-M Fuentes-Pérez, Y R Huerta-Villalobos, A A Cruz, R Stelmach, J da Silva, R Emuzyte, V Kvedariene, A Valiulis, I Annesi-Maesano, I Bosse, P Demoly, P Devillier, J F Fontaine, P Kuna, B Samolinski, L Klimek, R Mösges, O Pfaar, S Shamai, M Bewick, D Ryan, A Sheikh, J M Anto, V Cardona, J Mullol, A Valero, N H Chavannes, W J Fokkens, S Reitsma, R E Roller-Wirnsberger, P V Tomazic, T Haahtela, S Toppila-Salmi, E Valovirta, M Makris, N G Papadopoulos, E P Prokopakis, F Psarros, B Gemicioğlu, A Yorgancioglu, C Bindslev-Jensen, E Eller, I Kull, M Wickman, C Bachert, P W Hellings, B Pugin, S Bosnic-Anticevich, R E O'Hehir, V Kolek, M Sova, K Wehner, G De Vries, M van Eerd, D Laune, J Wittmann, J Bousquet, P Poncelet
Background: Collecting data on the localization of users is a key issue for the MASK (Mobile Airways Sentinel networK: the Allergy Diary) App. Data anonymization is a method of sanitization for privacy. The European Commission's Article 29 Working Party stated that geolocation information is personal data.To assess geolocation using the MASK method and to compare two anonymization methods in the MASK database to find an optimal privacy method. Methods: Geolocation was studied for all people who used the Allergy Diary App from December 2015 to November 2017 and who reported medical outcomes...
2018: World Allergy Organization Journal
Pavel Kolkhir, Dmitry Pogorelov, Razvigor Darlenski, Marco Caminati, Luciana Kase Tanno, Duy Le Pham, Alexei Gonzalez-Estrada, Darío Antolín-Amérigo, Ves Dimov, Karsten Weller, Mario Sánchez-Borges, Ignacio Ansotegui, Marcus Maurer
Background: The approaches to the diagnosis and treatment of chronic spontaneous urticaria (CSU) differ in various parts of the world. We sought to determine the adherence to international and national urticaria guidelines as well as the motives to deviate from the guidelines among physicians worldwide. Methods: A web-based questionnaire was created and launched via e-mail by the World Allergy Organization (WAO) to representatives of all WAO Member Societies, the members of the American Academy of Allergy, Asthma & Immunology (AAAAI) and the members of the WAO Junior Members Group (JMG), regardless of the specialty, affiliation, or nationality in March 2017...
2018: World Allergy Organization Journal
Marco Caminati, Duy Le Pham, Diego Bagnasco, Giorgio Walter Canonica
Type 2-immunity represents the typical adaptive response to allergen exposure in atopic individuals. It mainly involves Th2 cells and immunoglobulin E, as the main orchestrators of type 2-inflammation. Recently, it has been highlighted that allergens may be responsible for a Th2 response beside specific IgE activation and that a number of other environmental stimuli, such as viruses and pollutants, can trigger the same pattern of inflammation beyond atopy. Emerging data sustain a substantial role of the so-called epithelial dysfunction in asthma pathogenesis, both from anatomic and functional point of view...
2018: World Allergy Organization Journal
Wenyin Loh, Mimi L K Tang
Oral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow's milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustained unresponsiveness in food allergic patients. Sustained unresponsiveness, determined by a food challenge following a period of secondary avoidance, has been suggested to reflect a more enduring state of tolerance and is pertinent when considering the ability of OIT to shorten the duration of food allergy...
2018: World Allergy Organization Journal
Valentina Pecora, Rocco Luigi Valluzzi, Maurizio Mennini, Vincenzo Fierro, Lamia Dahdah
The development of oral tolerance or food allergy is an active process, related to dynamic interactions between host immune cells, microbiome, dietary factors, and food allergens. Oral tolerance is the default immune response in the gut. A food allergy occurs when this process fails and a pathologic Th2 response is activated. Oral food immunotherapy (OIT) aims to restore immune tolerance in food-allergic individuals. The stimulation of Tregs production seems to represent a crucial step in inducing long-term tolerance, but other mechanisms (e...
2018: World Allergy Organization Journal
K P Best, T R Sullivan, D J Palmer, M Gold, J Martin, D Kennedy, M Makrides
Background: Randomized controlled trials of prenatal omega (ω-3) long chain polyunsaturated fatty acid (LCPUFA) supplementation are suggestive of some protective effects on allergic sensitization and symptoms of allergic disease in childhood. Due to the nature of the atopic march, investigation of any effects of this prenatal intervention may be most informative when consistently assessed longitudinally during childhood. Methods: Follow-up of children ( n  = 706) with familial risk of allergy from the Docosahexaenoic Acid to Optimize Mother Infant Outcome (DOMInO) trial...
2018: World Allergy Organization Journal
Jens Christian Richter, Kristina Jakobsson, Tahir Taj, Anna Oudin
Background: Atopic disorders are a global concern. Studies in migrant populations can illuminate the interplay of genetic and environmental factors. Exposures related to bad housing (indoor dampness, mould growth, crowding etc.) are likely to play a role in how socioeconomic inequalities can turn into health disparities for disadvantaged populations. The sizable immigrant population living in very poor-quality housing in Malmö, Sweden, became the focus of a cross-sectional study. Objective: To describe atopic disorders and sensitizations in a population living in substandard housing in Malmö, Sweden, with an emphasis on their relation to harmful exposures from the built environment...
2018: World Allergy Organization Journal
Mario Sánchez-Borges, Bryan L Martin, Antonella M Muraro, Robert A Wood, Ioana O Agache, Ignacio J Ansotegui, Thomas B Casale, Thomas A Fleisher, Peter W Hellings, Nikolaos G Papadopoulos, David B Peden, James L Sublett, Stephen A Tilles, Lanny Rosenwasser
No abstract text is available yet for this article.
2018: World Allergy Organization Journal
Enrico Heffler, Francesca Puggioni, Silvia Peveri, Marcello Montagni, Giorgio Walter Canonica, Giovanni Melioli
Background: Precision medicine (PM) is changing the scope of allergy diagnosis and treatment. An in vitro IgE assay, a prototype PM method, was developed in the sixties and has garnered increasing interest because of the introduction of recombinant components in the test. More recently, microarrays of allergen components have significantly improved the ability to describe the IgE profile. Aim of this study was to evaluate the characteristics of the newly developed Allergy Explorer (ALEX), a macroarray containing both extracted "whole" allergens and molecular components...
2018: World Allergy Organization Journal
Hanna Hisinger-Mölkänen, Päivi Piirilä, Tari Haahtela, Anssi Sovijärvi, Paula Pallasaho
Background: Allergic and non-allergic rhinitis cause a lot of symptoms in everyday life. To decrease the burden more information of the preventable risk factors is needed. We assessed prevalence and risk factors for chronic nasal symptoms, exploring the effects of smoking, environmental tobacco smoke, exposure to occupational irritants, and their combinations. Methods: In 2016, a postal survey was conducted among a random population sample of 8000 adults in Helsinki, Finland with a 50...
2018: World Allergy Organization Journal
Stephanie A Leonard, Valentina Pecora, Alessandro Giovanni Fiocchi, Anna Nowak-Wegrzyn
Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated gastrointestinal food allergy that presents with delayed vomiting after ingestion primarily in infants. While the pathophysiology of FPIES is poorly understood, the clinical presentation of acute FPEIS reactions has been well characterized. The first International Consensus Guidelines for the Diagnosis and Management of Food Protein-induced Enterocolitis Syndrome were published in 2017 and reviewed epidemiology, clinical presentation, and prognosis of acute and chronic FPIES...
2018: World Allergy Organization Journal
Donatella Macchia, Gabriele Cortellini, Marina Mauro, Elisa Meucci, Oliviero Quercia, Mariangela Manfredi, Alessandro Massolo, Maurizio Valentini, Maurizio Severino, Giovanni Passalacqua
Background: In ascertained allergic sensitization to Vespa crabro (VC) venom, the European guidelines still consider venom immunotherapy (VIT) with Vespula (VE) venom sufficient to achieve an adequate protection against VC. However, antigen 5 immunoblotting studies showed that a genuine sensitization to VC venom may exist. In such cases, a specific VC venom would be preferable for VIT treatment. Since in the last few years, VC venom extracts became available for diagnosis and desensitization, we assessed the efficacy and safety of VIT with a VC-VIT, compared to VE extract...
2018: World Allergy Organization Journal
Alessandro Fiocchi, Holger Schunemann, Ignacio Ansotegui, Amal Assa'ad, Sami Bahna, Roberto Berni Canani, Martin Bozzola, Lamia Dahdah, Christophe Dupont, Motohiro Ebisawa, Elena Galli, Haiqi Li, Rose Kamenwa, Gideon Lack, Alberto Martelli, Ruby Pawankar, Maria Said, Mario Sánchez-Borges, Hugh Sampson, Raanan Shamir, Jonathan Spergel, Luigi Terracciano, Yvan Vandenplas, Carina Venter, Susan Waserman, Gary Wong, Jan Brozek
Background: The 2010 Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guidelines are the only Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines for cow's milk allergy (CMA). They indicate oral food challenge (OFC) as the reference test for diagnosis, and suggest the choice of specific alternative formula in different clinical conditions. Their recommendations are flexible, both in diagnosis and in treatment. Objectives & methods: Using the Scopus citation records, we evaluated the influence of the DRACMA guidelines on milk allergy literature...
2018: World Allergy Organization Journal
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