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International Journal of Clinical and Experimental Pathology

Casey M Inouye, Valsamo Anagnostou, Qing Kay Li
Background: Primary solid tumor metastasis to the spleen is a rare event, and often presents as an incidental finding without clinical symptoms of the patient. The most common primary tumors that metastasize to the spleen are colorectal, ovarian, and lung carcinomas. Parotid tumor metastasis to the spleen is extremely rare. We report an unusual case of metastatic parotid adenocarcinoma NOS (not otherwise specified) to the spleen. Case report: The patient presented with primary parotid carcinoma and underwent left parotidectomy...
2017: International Journal of Clinical and Experimental Pathology
Kaleigh Canfeld, Wendy Wells, Joseph Geradts, William B Kinlaw, Chao Cheng, Manabu Kurokawa
The ubiquitin E3 ligase MDM2 is best known for its ability to suppress the tumor suppressor p53. However, MDM2 also targets other proteins for proteasomal degradation and accumulating evidence strongly suggests p53-independent roles of MDM2 in cancer. We previously reported that MDM2 promotes degradation of another ubiquitin E3 ligase HUWE1 by ubiquitination, particularly, which confers HER2+ breast cancer cells resistance to the HER2 inhibitor lapatinib. However, it remains unclear whether such a mechanism can operate in other cell types, independently of HER2 inhibitors...
2016: International Journal of Clinical and Experimental Pathology
Zhiwei Wang, Ruie Feng, Yu Chen, Miao Duan, Man Wang, Zhengyu Jin, Zoran Rumboldt, Zhuhua Zhang
The submandibular gland is one of the most frequently affected salivary gland in IgG4-related systemic disease, usually demonstrate homogeneous attenuation on CT imaging as reported, but without much pathological comparison of many cases. This article is to investigate and analyze the typical CT findings and pathologic characteristics of IgG4-related systemic disease (IgG4-RSD) of submandibular gland. A retrospective analysis of the preoperative CT findings in patients with IgG4-RSD of submandibular glands who underwent surgical resection between January 2010 and February 2014 was performed...
2015: International Journal of Clinical and Experimental Pathology
Cui Xia, Kang Zhu, Guoxi Zheng
Epstein-Barr virus (EBV) is an important non-invasive index for nasopharyngeal carcinoma. Serum sialic acid (SA) level was known to be related with tumor progression. Rta protein antibody IgG (Rta-IgG), early antigen antibody (EA-IgA) and viral capsid antibody (VCA-IgA) levels in serum can also be used to effectively monitor the progression of cancer. This study investigated serum level of SA, Rta-IgG, EA-IgA and VCA-IgA in nasopharyngeal cancer patients and the diagnostic value of combined assay. A total of 64 nasopharyngeal cancer patients were recruited, in parallel with 60 benign rhinitis and 60 healthy individuals...
2015: International Journal of Clinical and Experimental Pathology
Zhi-Heng Liu, Jun-Li Huo, Zhi-Gang Wu, Zhen Sun, Feng Bai, Dino Samartzis, Benjamin Gantenbein, Shao-Di Fan, Hai-Qiang Wang
Apoptosis plays an important role in intervertebral disc degeneration (IDD). Overwhelming evidence indicates that RASSF7 is essential for cell growth and apoptosis. Recently, it has been noted that the JNK signaling can be negatively regulated by suppressing phosphorylated-MKK7 activation during pro-apoptosis. We aimed to investigate the RASSF7 expression level in human degenerative nucleus pulposus (NP) cells and non-degenerative NP cells and the link between RASSF7-JNK with NP cells apoptosis. We harvested NP tissues from 20 IDD patients as disease group and 8 cadaveric donors as normal controls...
2015: International Journal of Clinical and Experimental Pathology
Caterina Chiappetta, Chiara Puggioni, Eugenio Lendaro, Jessica Cacciotti, Roberto Zaralli, Giovanna Migliore, Paola Bellardini, Vincenzo Petrozza, Carlo Della Rocca, Claudio Di Cristofano
With cervical cancer screening the choice of 1-year as a period of follow-up in positive high-risk HPV women without cytological lesions is still under discussion. We evaluated the management of these women and the role of HPV genotyping test. We did a cervical cancer screening study of women aged 35-64 with primary high-risk HPV test. Women positive for high-risk HPV with negative cytology were followed-up after 1 year. In this study we selected women with high-risk HPV+/PapTest- resulted high-risk HPV+ at recall and performed the PapTest and HPV genotyping test...
2015: International Journal of Clinical and Experimental Pathology
Kun Liu, Hong-Lin Chen, Ming-Ming Gu, Qing-Sheng You
BACKGROUND: To study the prognosis-predicting value of a risk score based on phosphorylated At (p-Akt), vascular endothelial growth factor (VEGF), and Nin one binding (NOB1) expression in patients with resected non-small-cell lung cancer (NSCLC). METHODS: A prospective cohort among 98 consecutive patients with resected NSCLC was conducted in 2009 to 2010. Immunohistochemistry was used in the detection of p-Akt, VEGF, and NOB1 expression. Any of three genes with positive expression was allocated a score of 1, otherwise scored 0...
2015: International Journal of Clinical and Experimental Pathology
Ling-Yu Zhou, Jia-Yu Yin, Qin Tang, Ling-Ling Zhai, Tin-Juan Zhang, Yu-Xin Wang, Dong-Qin Yang, Jun Qian, Jiang Lin, Zhao-Qun Deng
The purpose of this study was to investigate the expression status of Dual-Specificity Phosphatase 5 Pseudogene 1 (DUSP5P1) and its clinical relevance in patients with acute myeloid leukemia (AML). Real-time quantitative PCR (RQ-PCR) was performed to detect the status of DUSP5P1 expression in 89 patients with de novo AML and 24 normal controls. The level of DUSP5P1 expression was significantly up-regulated in AML compared to controls (P=0.031). The patients with high expression of DUSP5P1 had higher percentage of blasts in bone marrow (BM) than those without high expression (P=0...
2015: International Journal of Clinical and Experimental Pathology
Bin Chen, Guoqing Zhao, Qingjie Ma, Bin Ji, Tiefeng Ji, Hua Xin, Shi Gao
The present study assessed the predictive value of (99m)Tc-3(poly-(ethylene glycol), PEG) 4-arginine-glycine-aspartic ((99m)Tc-3P-RGD2) single photon emission computed tomography (SPECT) for the early identification of response to antiangiogenic treatment with bevacizumab in patients with advanced non-small cell lung cancer (NSCLC). Patients with advanced NSCLC treated with bevacizumab were prospectively studied with (99m)Tc-3P-RGD2 SPECT before and after 2 weeks from start of treatment. The tumor response was evaluated with RECIST criteria and related to observed change in the tumor to non-tumor (T/N) ratio for the largest known lesion...
2015: International Journal of Clinical and Experimental Pathology
Xianjun Lao, Shan Ren, Yu Lu, Dongmei Yang, Xue Qin, Shan Li
C-reactive protein (CRP) is a biomarker of inflammation and the production has been shown to be influenced by genetic variation in CRP gene. HBV-related hepatocellular carcinoma (HCC) is a typical inflammation-related disease occurs mainly in men. The present study was designed to investigate the association between CRP polymorphisms and HBV-related HCC risk in a Chinese male population. The CRP rs2794521 and rs3093059 SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP) in 158 HBV patients with HCC, 207 HBV patients without HCC, and 150 unrelated healthy controls...
2015: International Journal of Clinical and Experimental Pathology
Bangrong Cao, Lei Yang, Weiqi Rong, Lin Feng, Naijun Han, Kaitai Zhang, Shujun Cheng, Jianxiong Wu, Ting Xiao, Yanning Gao
This study aimed to assess the diagnostic value of the latent transforming growth factor-beta binding protein-1 (LTBP-1) in distinguishing hepatocellular carcinoma (HCC) from patients with hepatitis or liver cirrhosis. The protein levels of LTBP-1 or AFP in circulating plasma were measured by enzyme-linked immunosorbent assay (ELISA) or chemiluminescence in four cohorts: HCC (n = 167), liver cirrhosis (n = 50), chronic hepatitis B (CHB, n = 50), and healthy individuals (n = 104). Receiver operating characteristics (ROC) curves and area under the curves (AUC) of the proteins were calculated...
2015: International Journal of Clinical and Experimental Pathology
Chen Wang, Qiaohong Lai, Shu Zhang, Jun Hu
Polymorphisms of DNA repair enzymes which may influence their repair efficiency lead to diseases, for example, senile cataract. In this study, we aimed to analyze the association of single nucleotide polymorphisms in AP endonuclease-1 (APE1), 8-oxoguanine glycosylase-1 (OGG1) and X-ray repair cross-complementing-1 (XRCC1) genes with the risk of age-related cataract in a Chinese population. Genotyping was carried out by the polymerase chain reaction and DNA sequencing on 402 cataract patients and 813 controls in this study...
2015: International Journal of Clinical and Experimental Pathology
Shuhua Wu, Tangyue Li, Qinghai Mu, Yangyang Li, Xiangqian Gao, Shuang He, Chenbo Sun
AIMS: To evaluate the expression and clinical significance of PI3Kp110α and PI3Kp110β in colorectal conventional adenoma, serrated lesions and adenoma with canceration. METHODS AND RESULTS: Immunohistochemistry and Western blot analysis were conducted to detect the expression of p110α and p110β in normal colorectal tissues, conventional adenoma, serrated lesions and adenoma canceration. Results revealed that the expression of P110α and P110β in the adenoma canceration was significantly higher than that in normal tissues, tubular adenoma (low grade) and tubular-villous adenoma (low grade) of conventional adenoma, hyperplastic polyps of serrated lesions (P<0...
2015: International Journal of Clinical and Experimental Pathology
Xuning Wang, Yue Zhang, Liang Huang, Jiajin Zhang, Fei Pan, Bing Li, Yongfeng Yan, Baoqing Jia, Hongyi Liu, Shiyou Li, Wei Zheng
Circular RNA (circRNA) is a type of RNAs which, unlike the better known linear RNA, forms a covalently closed continuous loop. They have emerged recently as a new player in governing fundamental biological processes. However it remains elusive about the correlation of hsa_circ_001988 abundance with colorectal cancer. To investigate the circular RNA expression in colorectal cancer, the targeted hsa_circ_001988 was selected from next generation sequence data base generated in house and then designed divergent primers to amplify hsa_circ_001988 and sequenced it for validation...
2015: International Journal of Clinical and Experimental Pathology
Xin-Liang Yao, Xue-Li Lu, Cheng-Yun Yan, Qi-Lin Wan, Guan-Chang Cheng, Yan-Ming Li
BACKGROUND: MicroRNAs (miRNAs) play key roles in cardiac development, and the expression of miRNAs is altered in the diseased heart. The aim of this study was to explore the value of circulating microRNA-122-5p (miR-122-5p) as a potential biomarker for acute myocardial infarction (AMI). METHODS: Plasma samples from 50 patients with AMI and 39 healthy adults (non-AMI controls) were collected. The abundance of circulating miR-122-5p was measured using quantitative real-time PCR (qRT-PCR)...
2015: International Journal of Clinical and Experimental Pathology
Jingdong He, Jin Li, Wanting Feng, Longbang Chen, Kangqun Yang
Interferon-induced transmembrane protein 1 (IFITM1) has recently been implicated in tumorigenesis. However, the prognostic value of IFITM1 in colorectal cancer remains unknown. The present study aimed to examine the expression and prognostic significance of IFITM1 in human colorectal cancer. IFITM1 expression was analyzed in 144 archived, paraffin-embedded colorectal cancer tissues and corresponding normal colorectal mucosa by immunohistochemistry. The correlation of IFITM1 with clinic-pathological features and overall survival of colorectal cancer patients was evaluated...
2015: International Journal of Clinical and Experimental Pathology
Omar I Saadah, Sameer E Al-Harthi, Jamil A Al-Mughales, Yagoub Y Bin-Taleb, Raed S Baeshen
Interleukin-33 (IL-33) is a cytokine that belongs to the interleukin-1 family and has been shown to be associated with mucosal inflammation. The aim of this study was to determine the serum level of IL-33 in children with ulcerative colitis (UC) and Crohn's disease (CD) and to correlate the level with the disease progression. In this cross sectional prospective study, we enrolled 50 children with IBD from KAUH, Jeddah, Saudi Arabia and 34 healthy control subjects between June 2012 and December 2012. Serum IL-33 was assessed by ELISA and CRP by immunonephelometric assay...
2015: International Journal of Clinical and Experimental Pathology
Bing Li, Yuemei Xu, Danqing Pan, Qian Xiao, Qi Gao, Xin Chen, Xiuhua Peng, Yuling Du, Pengfei Gao
Maternal stress exerts long-lasting postnatal growth on offspring, which persist into adulthood. However, the effect of maternal stress on appetizing system has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in low body weight and food intake. Immunohistochemistry showed an increase in stomach ghrelin protein expression. The central regulation of body weight and food intake occurs in the hypothalamus, which contains multiple neuronal systems that play important roles in the regulation of energy homeostasis...
2015: International Journal of Clinical and Experimental Pathology
Sheng Zheng, Juan Yang, Yingmei Tang, Jinhui Yang, Qinghua Shao, Ling Guo, Qinghua Liu
OBJECTIVE: This study aimed to investigate the effect of bone marrow mesenchymal stem cells (BMSCs) transplantation on the expression of high mobility group box 1 protein (HMGB1) in the serum and liver of rats with acute liver failure (ALF). METHODS: Healthy male SD rats were randomly divided into control group, ALF group and BMSCs group. ALF was induced by intraperitoneal injection of 900 mg/kg D-GalN and 10 μg/kg LPS. In BMSCs group, rats received BMSCs (1.0×10(7)) transplantation via the tail vein at 2 h after ALF induction...
2015: International Journal of Clinical and Experimental Pathology
Vesna Janevska, Adelina Qerimi, Neli Basheska, Elena Stojkova, Vlado Janevski, Rubens Jovanovic, Julija Zhivadinovik, Liljana Spasevska
OBJECTIVE: Some authors suggest common origin of gastrointestinal stromal tumors from stem cells, which may show diverse differentiation. There are reports in which cells morphologically identical to the interstitial cells of Cajal are found in deep leiomyomas. The aim of this study was to demonstrate CD117 positive cells in superficial gastrointestinal (GI) leiomyomas and to find other cells that would suggest diverse differentiation in histologically typical leiomyoma. MATERIALS AND METHODS: We analyzed 8 cases of superficial leiomyomas and one deep leiomyoma, received in our institutions as endoscopically or surgically obtained material...
2015: International Journal of Clinical and Experimental Pathology
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