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Open Rheumatology Journal

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https://www.readbyqxmd.com/read/28077980/a-review-of-chikungunya-virus-induced-arthralgia-clinical-manifestations-therapeutics-and-pathogenesis
#1
Brad A Goupil, Christopher N Mores
BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions, potentially affecting over 1 billion people. Recently, an outbreak began in the western hemisphere and has resulted in over 1.8 million reported suspected cases. Infection often results in severe fever, rash and debilitating polyarthralgia lasting weeks to months. Additionally, the current literature reports that CHIKV can result in a severe chronic arthralgia and/or arthritis that can last months to years following the initial infection...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28077979/anti-mda5-antibody-dermatomyositis-overlap-with-systemic-lupus-erythematosus-a-case-report-and-review-of-the-literature
#2
Emily C Milam, Jacobo Futran, Andrew G Franks
BACKGROUND: Dermatomyositis (DM) is an autoimmune connective tissue disease that primarily targets the muscle, skin, and lungs. Many patients have autoantibodies that correspond to distinct clinical phenotypes. Melanoma differentiation-associated gene 5 (anti-MDA5) antibody, a specific antibody that targets the melanoma differentiation-associated gene 5 (MDA5), has been reported in DM cases and is significant for a distinct cutaneous presentation and rapidly progressive interstitial lung disease...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28077978/fibromyalgia-outcomes-over-time-results-from-a-prospective-observational-study-in-the-united-states
#3
Caroline P Schaefer, Edgar H Adams, Margarita Udall, Elizabeth T Masters, Rachael M Mann, Shoshana R Daniel, Heather J McElroy, Joseph C Cappelleri, Andrew G Clair, Markay Hopps, Roland Staud, Philip Mease, Stuart L Silverman
BACKGROUND: Longitudinal research on outcomes of patients with fibromyalgia is limited. OBJECTIVE: To assess clinician and patient-reported outcomes over time among fibromyalgia patients. METHODS: At enrollment (Baseline) and follow-up (approximately 2 years later), consented patients were screened for chronic widespread pain (CWP), attended a physician site visit to determine fibromyalgia status, and completed an online questionnaire assessing pain, sleep, function, health status, productivity, medications, and healthcare resource use...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28077977/two-subsets-of-large-vessel-vasculitis-characterized-by-the-absence-or-presence-of-spondyloarthritis-or-its-associated-diseases
#4
Diana Ernst, Niklas Bearlecken, Reinhold Ernst Schmidt, Torsten Witte
BACKGROUND: Whilst large vessel vasculitis (LVV) predominantly occurs in isolation, associations with other infectious and non-infectious diseases have been reported. Limited data describing associations with various autoimmune diseases (AI), including spondyloarthritis exists. The aim of this study was to characterize the association of LVV and spondyloarthritis or its associated diseases (SpAD). METHODS: A single centre, retrospective study of patients ≥50yrs with first presentation LVV between 01...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27867433/open-label-study-of-initial-and-repeat-treatment-cycles-of-hylan-g-f-20-in-patients-with-symptomatic-knee-osteoarthritis
#5
Robert Heger, Günther Paulsen, Ulrich Fickert, Michael Kresmann
OBJECTIVE: To evaluate the efficacy and safety of initial and repeat treatment with hylan G-F 20 in patients with symptomatic osteoarthritis (OA) of the knee. METHODS: A prospective, multicenter, open-label study in adult patients with symptomatic knee OA (Kellgren-Lawrence grades I-III) undergoing repeat (SC group) or initial (IC group) treatment courses (3 x 2 mL of hylan G-F 20 at weekly intervals) was conducted with a maximum follow-up of 26 weeks. Reduction of pain using the Verbal Pain Questionnaire (VPQ) and Patient Global Assessment (PTGA) scores, concomitant pain medications use, and adverse events (AEs) were evaluated...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27867432/arthritis-of-the-knee-joint-in-rheumatoid-arthritis-evaluation-of-treatment-response-by-ultrasound-in-daily-clinical-practice
#6
V S Schäfer, W A Schmidt, M Backhaus, W Hartung
BACKGROUND: Rheumatoid arthritis (RA) commonly involves the knee joint in up to 30% of patients. Musculoskeletal ultrasound enables the skilled clinician to easily assess disease activity. OBJECTIVE: To evaluate the sensitivity to change of the sonography score of large joints in Rheumatology (SOLAR) for different treatments of knee arthritis in RA. METHOD: Joints were assessed by ultrasound at 4 visits. Laboratory, immunological and clinical parameters were recorded...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27867431/the-avise-lupus-test-and-cell-bound-complement-activation-products-aid-the-diagnosis-of-systemic-lupus-erythematosus
#7
James Mossell, John A Goldman, Derren Barken, Roberta Vezza Alexander
BACKGROUND: Systemic lupus erythematosus (SLE) is a multifaceted disease, and its diagnosis may be challenging. A blood test for the diagnosis of SLE, the Avise Lupus test, has been recently commercialized and validated in clinical studies. OBJECTIVES: To evaluate the use of the Avise Lupus test by community rheumatologists. METHODS: The study is a longitudinal, case-control, retrospective review of medical charts. Cases had a positive test result, and controls had a negative result; all patients were anti-nuclear antibodies (ANA) positive but negative for SLE-specific autoantibodies...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27857821/carotid-artery-atherosclerosis-in-patients-with-active-rheumatoid-arthritis-predictors-of-plaque-occurrence-and-progression-over-24-weeks
#8
Janet E Pope, Tatiana Nevskaya, Lillian Barra, Grace Parraga
INTRODUCTION: This study evaluated the prevalence and progression of subclinical carotid artery atherosclerosis in active rheumatoid arthritis (RA). METHODS: Carotid arteries of RA patients were scanned using 3D ultrasound at baseline and 24 weeks for total plaque area, vessel wall volume, and intima-media thickness (IMT), as well as arterial stiffness measured using pulse wave velocity. Variables related to inflammation, lipids and cardiovascular (CV) risk were assessed for associations with plaque progression...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27843510/medication-related-self-management-behaviors-among-arthritis-patients-does-attentional-coping-style-matter
#9
Lorie L Geryk, Susan J Blalock, Robert F DeVellis, Joanne M Jordan, Paul K J Han, Delesha M Carpenter
OBJECTIVE: The aim of this study was to investigate the relationship between the attentional coping styles (monitoring and blunting) of rheumatoid arthritis (RA) and osteoarthritis (OA) patients and: (a) receipt of medication information; (b) receipt of conflicting medication information; (c) ambiguity aversion; (d) medication-related discussions with doctors and spouse/partners; and (e) medication adherence. METHOD: A sample of 328 adults with a self-reported diagnosis of arthritis (RA n=159; OA n=149) completed an Internet-based survey...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27708728/hepatitis-b-serology-in-patients-with-rheumatic-diseases
#10
Martin Feuchtenberger, Arne Schäfer, Axel Philipp Nigg, Michael Rupert Kraus
BACKGROUND: Only limited data are available on the prevalence of hepatitis B in patients with proven rheumatic diseases and thus the risk of reactivation under immunosuppressive therapy. OBJECTIVE: To analyse hepatitis B serology in patients with rheumatic diseases prior to therapy. METHOD: In total, 1,338 patient records were analysed for HBsAg, HBsAb and HBcAb in a cross-sectional, single-centre study between 2011 and 2015 at first presentation...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27053971/igg4-related-lung-disease-associated-with-usual-interstitial-pneumonia
#11
Frank Schneider, Kristen L Veraldi, Marc C Levesque, Thomas V Colby, Eunhee S Yi
We report a case of immunoglobulin(Ig)G4-related disease with the radiologic and histopathological manifestations resembling usual interstitial pneumonia (UIP). The patient was a 62-year-old man who presented with progressive dyspnea of insidious onset. High resolution computed tomography of the chest showed lower-lobe predominant peripheral reticulation and traction bronchiectasis but no honeycomb change. Microscopic examination of the surgical lung biopsy showed characteristic features of UIP including architectural distortion by fibrosis with peripheral and paraseptal accentuation, scattered fibroblast foci and microscopic honeycomb change...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27053970/is-hearing-impairment-associated-with-rheumatoid-arthritis-a-review
#12
Amir Emamifar, Kristine Bjoerndal, Inger M J Hansen
BACKGROUND: Rheumatoid arthritis (RA) is a systemic, inflammatory disease that affects 1% of the population. The auditory system may be involved during the course of disease; however the association of RA and hearing impairment has not been clearly defined. OBJECTIVE: The objective of this review is to evaluate published clinical reports related to hearing impairment in patients with RA. Furthermore, we discuss possible pathologies and associated factors as well as new treatment modalities...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27047576/association-study-of-single-nucleotide-polymorphisms-rs4552569-rs17095830-with-ankylosing-spondylitis-in-a-chinese-population
#13
Qingwen Wang, Yuanyuan Yang, Jiyang Lv, Qi Lin, Luo Wang, Zhengyu Fanga
Genetics play a key role in ankylosing spondylitis (AS). A previous genome-wide association study (GWAS) showed that rs4552569 (on 5q14.3) and rs17095830 (on 12q12) were associated with the risk of AS in Han Chinese, which was not replicated in other two studies. In the current study, rs4552569 and rs17095830 were genotyped in 735 Han Chinese AS patients and 1204 healthy controls using high resolution melting analysis (HRMA). We compared the distributions of genotypes and alleles between AS cases and healthy controls...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27006728/two-year-safety-and-efficacy-experience-in-patients-with-methotrexate-resistant-active-rheumatoid-arthritis-treated-with-etanercept-and-conventional-disease-modifying-anti-rheumatic-drugs-in-the-latin-american-region
#14
Daniel A Machado, Renato Guzman, Ricardo M Xavier, Jesus A Simon, Linda Mele, Qi Shen, Ronald Pedersen, Sameer Kotak, Bonnie Vlahos
BACKGROUND: Although long-term data are available from biologic studies in North American/European populations with rheumatoid arthritis (RA), long-term findings in Latin American RA populations are limited. OBJECTIVE: To examine long-term safety/efficacy of etanercept, methotrexate, and/or other disease-modifying anti-rheumatic drugs (DMARDs) in Latin American patients with moderate-to-severe active RA. METHODS: In the first phase of this open-label study, patients were randomized to etanercept 50 mg weekly plus methotrexate or conventional DMARD (hydroxychloroquine or sulfasalazine) plus methotrexate for 24 weeks...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27006727/an-open-randomized-trial-comparing-the-effects-of-oral-nsaids-versus-steroid-intra-articular-infiltration-in-congestive-osteoarthritis-of-the-knee
#15
Ouédraogo Dieu-Donné, Ouédraogo Théodore, Zabsonré Tiendrébéogo Joëlle, Dionou Pierre, Ouédraogo Smaïla, Compaoré Christian, Kaboré Fulgence, Drabo Youssouf Joseph
OBJECTIVE: To compare the efficacy on pain and joint function of NSAIDs versus steroid intra-articular infiltration in congestive knee osteoarthritis. PATIENTS AND METHODS: Open randomized study comparing a series of patients treated with NSAIDs for 21 days and another who received steroid intra-articular infiltration (SIAI) spaced at every 7 days. The visual analog scale was used for the weekly assessment of spontaneous pain and pain when walking. Lequesne functional pain scale was used to assess the functional impact of knee osteoarthritis...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/26862354/associations-of-mica-polymorphisms-with-inflammatory-rheumatic-diseases
#16
Qingwen Wang, Xiaodong Zhou
Inflammatory rheumatic diseases are characterized by inflammation resulting from the immune dysregulation that usually attacks joints, skin and internal organs. Many of them are considered as complex disease that may be predisposed by multiple genes and/or genetic loci, and triggered by environmental factors such as microbiome and cellular stress. The major histocompatibility complex class I chain-related gene A (MICA) is a highly polymorphic gene that encodes protein variants expressed under cellular stress conditions, and these MICA variants play important roles in immune activation and surveillance...
2015: Open Rheumatology Journal
https://www.readbyqxmd.com/read/26862353/determinants-of-disability-in-rheumatoid-arthritis-a-community-based-cohort-study
#17
Megan L Krause, Cynthia S Crowson, Tim Bongartz, Eric L Matteson, Clement J Michet, Thomas G Mason, Scott T Persellin, Sherine E Gabriel, John M Davis
Longitudinal care of a community-based cohort of patients with rheumatoid arthritis (RA) was evaluated retrospectively. Candidate determinants of disability included visual analog scales (VAS) for patient global assessment and pain, comorbidities, and medications. The outcome was the 'patient-acceptable symptom state' for disability as defined by the Health Assessment Questionnaire (HAQ) disability index, using a cutoff of <1.04. Two-sample t tests and multivariable logistic regression were used to determine odds ratios (OR) for associations between predictor variables and disability...
2015: Open Rheumatology Journal
https://www.readbyqxmd.com/read/26862352/applying-choosing-wisely-antinuclear-antibody-ana-and-sub-serology-testing-in-a-safety-net-hospital-system
#18
Lisa Anne Davis, Barbara Goldstein, Vivian Tran, Angela Keniston, Jinoos Yazdany, Joel Hirsh, Amy Storfa, JoAnn Zell
OBJECTIVE: In 2013, the American College of Rheumatology (ACR) participated in the Choosing Wisely campaign and devised a recommendation to avoid testing antinuclear antibody (ANA) subserologies without a positive ANA and clinical suspicion of disease. The goals of our study were to describe ANA and subserology ordering practices and predictors of ordering concurrent ANA and subserologies in a safety-net hospital. METHODS: We identified ANA and subserologies (dsDNA, Sm, RNP, SSA, SSB, Scl-70 and centromere) completed at Denver Health between 1/1/2005 and 12/31/2011...
2015: Open Rheumatology Journal
https://www.readbyqxmd.com/read/26668670/intravenous-immune-globulin-in-amyopathic-dermatomyositis-report-of-two-cases-and-review-of-the-literature
#19
John M Cafardi, Naveed Sami
Amyopathic dermatomyositis (ADM) is a rare subtype of dermatomyositis which is often recalcitrant to immune suppressing treatments. Intravenous immunoglobulin (IVIG) has been used in the treatment of refractory dermatomyositis. We present two patients with severe ADM, who were treated with IVIG at 2 g/kg every four weeks. Both patients had a successful response and were able to taper the dosage of prednisone. We present both cases in describing IVIG as a rescue and maintenance steroid-sparing agent in the treatment of severe refractory ADM...
2015: Open Rheumatology Journal
https://www.readbyqxmd.com/read/26535070/diagnostic-value-of-procalcitonin-in-anca-associated-vasculitis-aav-to-differentiate-between-disease-activity-infection-and-drug-hypersensitivity
#20
K Herrmann, S Schinke, E Csernok, F Moosig, J U Holle
OBJECTIVE: Procalcitonin (PCT) is considered to be a specific marker for severe bacterial infections and sepsis. Elevated PCT levels have been reported in active autoimmune diseases without infection. The aim of this study was to assess the diagnostic value of PCT serum levels in ANCA-associated vasculitis (AAV) patients with respect to infection, disease activity and drug fever using a high sensitive PCT detection method. METHODS: In 53 AAV patients with elevated C-reactive protein (CRP) PCT was determined by the Thermo Scientific BRAHMS PCT sensitive KRYPTOR assay...
2015: Open Rheumatology Journal
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