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Open Rheumatology Journal

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https://www.readbyqxmd.com/read/28761564/predictive-value-of-serum-infliximab-levels-at-induction-phase-in-rheumatoid-arthritis-patients
#1
Jurado Teresa, Plasencia-Rodríguez Chamaida, Martínez-Feito Ana, Navarro-Compán Victoria, Rispens Theo, Vries Annick, Bloem Karien, Olariaga Eva-María, Diego Cristina, Villalba Alejandro, Peiteado Diana, Nuño Laura, Bonilla Maria-Gema, Balsa Alejandro, Pascual-Salcedo Dora
BACKGROUND: The Infliximab, has proven effective in treating rheumatoid arthritis (RA). A good clinical response is usually associated with high serum drug levels. Development of antibodies toward Infliximab (ATI) can increase drug clearance, leading to treatment failure. AIMS: To analyze whether serum Infliximab trough levels (ITL) at the induction phase are associated with Infliximab clearance and clinical outcomes at week(W) 54 and to investigate the association with immunogenicity development...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28659999/biological-effects-of-phosphocitrate-on-osteoarthritic-articular-chondrocytes
#2
Yubo Sun, Atiya M Franklin, David R Mauerhan, Edward N Hanley
BACKGROUND: Phosphocitrate (PC) inhibits osteoarthritis (OA) in Hartley guinea pigs. However, the underlying molecular mechanisms remain poorly understood. OBJECTIVE: This study sought to examine the biological effect of PC on OA chondrocytes and test the hypothesis that PC may exert its OA disease modifying effect, in part, by inhibiting the expression of genes implicated in OA disease process and stimulating the production of extracellular matrices. METHOD: OA chondrocytes were cultured in the absence or presence of PC...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28659998/axial-spondyloarthritis-and-cigarette-smoking
#3
Irène Kona Kaut, Fatima Ezzhara Abourazzak, Essouri Jamila, Florine Awassi Sènami, Desiré Diketa, Harzy Taoufik
BACKGROUND: Smoking is one of the main environmental risk factors involved in several rheumatic diseases according to ACR 2014, it is included among the risk factors for severe axial spondyloarthritis. OBJECTIVES: The objective is to study the association between smoking and the activity of the disease, the functional impact and the severity of the axial spondyloarthritis. METHODS: It is a transversal study with a descriptive and analytical aim, during the period between January 2014 and December 2015 conducted in the department of rheumatology at the CHU Hassan II of Fes...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28567148/hip-abductor-strengthening-improves-physical-function-following-total-knee-replacement-one-year-follow-up-of-a-randomized-pilot-study
#4
Karvannan Harikesavan, Raj D Chakravarty, Arun G Maiya, Sanjay P Hegde, Shivakumar Y Shivanna
BACKGROUND: Total knee replacement (TKR) is the commonest surgical procedure for patients with severe pain and impaired physical function following end stage knee osteoarthritis. The hip abductors are well renowned in stabilization of the trunk and hip during walking, maintaining the lower limb position, and transferring the forces from the lower limbs to the pelvis. OBJECTIVE: To assess the efficacy of hip abductor strengthening exercise on functional outcome using performance based outcome measures following total knee replacement...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28553419/the-use-of-patient-reported-outcome-measures-for-rheumatoid-arthritis-in-japan-a-systematic-literature-review
#5
REVIEW
Ann Chuo Tang, Hyunchung Kim, Bruce Crawford, Taeko Ishii, Tamas Treuer
BACKGROUND: Patient-reported outcomes (PRO) obtained through routine medical care may identify patients' day-to-day burden and help tackle the disease from the patients' perspective. However, there is a paucity of information regarding the availability of PRO data and PRO tools for rheumatoid arthritis (RA) in Japan. OBJECTIVE: We reviewed the literature on PRO data availability and to identify PRO measures implemented in Japan for RA patients. METHOD: We conducted a systematic literature review using ICHUSHI and the PubMed databases on PRO measures for RA published from January 2011 to August 2015 in Japan...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28400869/serum-cytokine-profile-in-asian-indian-patients-with-takayasu-arteritis-and-its-association-with-disease-activity
#6
Ruchika Goel, Jayakanthan Kabeerdoss, Babu Ram, John Antony Jude Prakash, Sudhir Babji, Aswin Nair, Lakshmanan Jeyaseelan, Visalakshi Jeyaseelan, John Mathew, Veeraraghavan Balaji, George Joseph, Debashish Danda
BACKGROUND: Arterial inflammation Takayasu arteritis (TA) is an outcome of balance between pro- and anti-inflammatory cytokines. Comprehensive assessment of these cytokines is important for understanding pathogenesis and assessing disease activity. OBJECTIVE: To study pro- and anti-inflammatory cytokines representing different T-helper cell pathway in serum samples of Asian Indian patients with TA and to assess their association with disease activity. METHODS: Consecutive Indian patients with TA were assayed for serum interferon-γ, interleukin-6, interleukin-23, interleukin-17, interleukin-10 and transforming growth factor- β levels at baseline and follow up visit...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28400868/use-of-saline-as-a-placebo-in-intra-articular-injections-in-osteoarthritis-potential-contributions-to-nociceptive-pain-relief
#7
REVIEW
David Bar-Or, Leonard T Rael, Edward N Brody
BACKGROUND: Osteoarthritis of the knee (OAK) is a severe debilitating condition characterized by joint pain, stiffness, and resultant limited mobility. In recent years, intra-articular (IA) injections have been used to relieve symptoms and have succeeded to varying degrees either with sodium hyaluronate preparations or with a biologic. OBJECTIVE: The objective of this review is to evaluate multiple studies that demonstrate some relief from the symptoms of OAK in the saline arm of various clinical trials...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28400867/evaluation-of-autoantibodies-in-patients-with-primary-and-secondary-sjogren-s-syndrome
#8
Ellen De Langhe, Xavier Bossuyt, Long Shen, Kishore Malyavantham, Julian L Ambrus, Lakshmanan Suresh
BACKGROUND: Antibodies to salivary gland protein 1 (SP1), carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP) were discovered in an animal model of Sjogren's syndrome (SS). Their expression was noted in patients with SS, especially those with lower focus scores on lip biopsies and those with early disease lacking antibodies to Ro and La. OBJECTIVE: The current studies evaluated these autoantibodies in patients with long-standing SS expressing high levels of anti-Ro antibodies and in patients with Sjogren's syndrome secondary to systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and mixed connective tissue disease (MCTD)...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28400866/association-of-erap1-il23r-and-ptger4-polymorphisms-with-radiographic-severity-of-ankylosing-spondylitis
#9
Gulsen Ozen, Rabia Deniz, Fatih Eren, Can Erzik, Ali Ugur Unal, Sule Yavuz, Sibel Zehra Aydin, Nevsun Inanc, Haner Direskeneli, Pamir Atagunduz
BACKGROUND: Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early. OBJECTIVE: To study the association between ERAP1, IL23R and PTGER4 single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients. METHODS: rs27044 and rs30187 (ERAP1), rs11209032 (IL23R) and rs10440635 (PTGER4) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28144368/the-correlation-of-muscle-biopsy-scores-with-the-clinical-variables-in-idiopathic-inflammatory-myopathies
#10
Suparaporn Wangkaew, Songkiet Suwansirikul, Kantawut Aroonrungwichian, Nuntana Kasitanon, Worawit Louthrenoo
OBJECTIVES: To compare the muscle pathology findings among subgroups of idiopathic inflammatory myopathies (IIM) patients, and to determine the correlations of muscle biopsy scores with muscle power and creatine kinase (CK). METHODS: The medical records of IIM patients consisting of the demographic data, clinical parameters and laboratory conducted were retrospectively reviewed. Their initial muscle biopsies were reviewed, and four domains were scored: inflammation, vascular, muscle, and connective tissue...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28077980/a-review-of-chikungunya-virus-induced-arthralgia-clinical-manifestations-therapeutics-and-pathogenesis
#11
Brad A Goupil, Christopher N Mores
BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions, potentially affecting over 1 billion people. Recently, an outbreak began in the western hemisphere and has resulted in over 1.8 million reported suspected cases. Infection often results in severe fever, rash and debilitating polyarthralgia lasting weeks to months. Additionally, the current literature reports that CHIKV can result in a severe chronic arthralgia and/or arthritis that can last months to years following the initial infection...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28077979/anti-mda5-antibody-dermatomyositis-overlap-with-systemic-lupus-erythematosus-a-case-report-and-review-of-the-literature
#12
Emily C Milam, Jacobo Futran, Andrew G Franks
BACKGROUND: Dermatomyositis (DM) is an autoimmune connective tissue disease that primarily targets the muscle, skin, and lungs. Many patients have autoantibodies that correspond to distinct clinical phenotypes. Melanoma differentiation-associated gene 5 (anti-MDA5) antibody, a specific antibody that targets the melanoma differentiation-associated gene 5 (MDA5), has been reported in DM cases and is significant for a distinct cutaneous presentation and rapidly progressive interstitial lung disease...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28077978/fibromyalgia-outcomes-over-time-results-from-a-prospective-observational-study-in-the-united-states
#13
Caroline P Schaefer, Edgar H Adams, Margarita Udall, Elizabeth T Masters, Rachael M Mann, Shoshana R Daniel, Heather J McElroy, Joseph C Cappelleri, Andrew G Clair, Markay Hopps, Roland Staud, Philip Mease, Stuart L Silverman
BACKGROUND: Longitudinal research on outcomes of patients with fibromyalgia is limited. OBJECTIVE: To assess clinician and patient-reported outcomes over time among fibromyalgia patients. METHODS: At enrollment (Baseline) and follow-up (approximately 2 years later), consented patients were screened for chronic widespread pain (CWP), attended a physician site visit to determine fibromyalgia status, and completed an online questionnaire assessing pain, sleep, function, health status, productivity, medications, and healthcare resource use...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28077977/two-subsets-of-large-vessel-vasculitis-characterized-by-the-absence-or-presence-of-spondyloarthritis-or-its-associated-diseases
#14
Diana Ernst, Niklas Bearlecken, Reinhold Ernst Schmidt, Torsten Witte
BACKGROUND: Whilst large vessel vasculitis (LVV) predominantly occurs in isolation, associations with other infectious and non-infectious diseases have been reported. Limited data describing associations with various autoimmune diseases (AI), including spondyloarthritis exists. The aim of this study was to characterize the association of LVV and spondyloarthritis or its associated diseases (SpAD). METHODS: A single centre, retrospective study of patients ≥50yrs with first presentation LVV between 01...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27867433/open-label-study-of-initial-and-repeat-treatment-cycles-of-hylan-g-f-20-in-patients-with-symptomatic-knee-osteoarthritis
#15
Robert Heger, Günther Paulsen, Ulrich Fickert, Michael Kresmann
OBJECTIVE: To evaluate the efficacy and safety of initial and repeat treatment with hylan G-F 20 in patients with symptomatic osteoarthritis (OA) of the knee. METHODS: A prospective, multicenter, open-label study in adult patients with symptomatic knee OA (Kellgren-Lawrence grades I-III) undergoing repeat (SC group) or initial (IC group) treatment courses (3 x 2 mL of hylan G-F 20 at weekly intervals) was conducted with a maximum follow-up of 26 weeks. Reduction of pain using the Verbal Pain Questionnaire (VPQ) and Patient Global Assessment (PTGA) scores, concomitant pain medications use, and adverse events (AEs) were evaluated...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27867432/arthritis-of-the-knee-joint-in-rheumatoid-arthritis-evaluation-of-treatment-response-by-ultrasound-in-daily-clinical-practice
#16
V S Schäfer, W A Schmidt, M Backhaus, W Hartung
BACKGROUND: Rheumatoid arthritis (RA) commonly involves the knee joint in up to 30% of patients. Musculoskeletal ultrasound enables the skilled clinician to easily assess disease activity. OBJECTIVE: To evaluate the sensitivity to change of the sonography score of large joints in Rheumatology (SOLAR) for different treatments of knee arthritis in RA. METHOD: Joints were assessed by ultrasound at 4 visits. Laboratory, immunological and clinical parameters were recorded...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27867431/the-avise-lupus-test-and-cell-bound-complement-activation-products-aid-the-diagnosis-of-systemic-lupus-erythematosus
#17
James Mossell, John A Goldman, Derren Barken, Roberta Vezza Alexander
BACKGROUND: Systemic lupus erythematosus (SLE) is a multifaceted disease, and its diagnosis may be challenging. A blood test for the diagnosis of SLE, the Avise Lupus test, has been recently commercialized and validated in clinical studies. OBJECTIVES: To evaluate the use of the Avise Lupus test by community rheumatologists. METHODS: The study is a longitudinal, case-control, retrospective review of medical charts. Cases had a positive test result, and controls had a negative result; all patients were anti-nuclear antibodies (ANA) positive but negative for SLE-specific autoantibodies...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27857821/carotid-artery-atherosclerosis-in-patients-with-active-rheumatoid-arthritis-predictors-of-plaque-occurrence-and-progression-over-24-weeks
#18
Janet E Pope, Tatiana Nevskaya, Lillian Barra, Grace Parraga
INTRODUCTION: This study evaluated the prevalence and progression of subclinical carotid artery atherosclerosis in active rheumatoid arthritis (RA). METHODS: Carotid arteries of RA patients were scanned using 3D ultrasound at baseline and 24 weeks for total plaque area, vessel wall volume, and intima-media thickness (IMT), as well as arterial stiffness measured using pulse wave velocity. Variables related to inflammation, lipids and cardiovascular (CV) risk were assessed for associations with plaque progression...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27843510/medication-related-self-management-behaviors-among-arthritis-patients-does-attentional-coping-style-matter
#19
Lorie L Geryk, Susan J Blalock, Robert F DeVellis, Joanne M Jordan, Paul K J Han, Delesha M Carpenter
OBJECTIVE: The aim of this study was to investigate the relationship between the attentional coping styles (monitoring and blunting) of rheumatoid arthritis (RA) and osteoarthritis (OA) patients and: (a) receipt of medication information; (b) receipt of conflicting medication information; (c) ambiguity aversion; (d) medication-related discussions with doctors and spouse/partners; and (e) medication adherence. METHOD: A sample of 328 adults with a self-reported diagnosis of arthritis (RA n=159; OA n=149) completed an Internet-based survey...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27708728/hepatitis-b-serology-in-patients-with-rheumatic-diseases
#20
Martin Feuchtenberger, Arne Schäfer, Axel Philipp Nigg, Michael Rupert Kraus
BACKGROUND: Only limited data are available on the prevalence of hepatitis B in patients with proven rheumatic diseases and thus the risk of reactivation under immunosuppressive therapy. OBJECTIVE: To analyse hepatitis B serology in patients with rheumatic diseases prior to therapy. METHOD: In total, 1,338 patient records were analysed for HBsAg, HBsAb and HBcAb in a cross-sectional, single-centre study between 2011 and 2015 at first presentation...
2016: Open Rheumatology Journal
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