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Open Ophthalmology Journal

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https://www.readbyqxmd.com/read/29399233/the-effect-of-ranibizumab-on-normal-neurosensory-retina-in-the-eyes-of-patients-with-exudative-age-related-macular-degeneration
#1
Olga E Makri, Demetrios Vavvas, Panagiotis Plotas, Athina Pallikari, Constantine D Georgakopoulos
Background: Anti-vascular endothelial growth factors have become the mainstay treatment for neovascular age related macular degeneration. Prolonged suppression of vascular endothelial growth factor raises concerns as it may result in harmful effects on retina. Objective: The purpose of this retrospective chart review is to evaluate the 1-year effect of treatment with intravitreal injections of ranibizumab on normal neurosensory retinal tissue of patients with exudative age related macular degeneration using the Optical Coherence Tomography (OCT)...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29299083/unilateral-adult-xanthogranulomatous-infiltration-of-the-conjunctiva-limbus-and-sclera-leading-to-a-combined-ophthalmic-artery-and-central-retinal-vein-occlusion
#2
Burak Unlu, Ziya Ayhan, Banu Lebe, Suleyman Men, Ismet Durak, Ali Osman Saatci
Objective: To describe the features of a female patient with a biopsy-proven xanthogranulomatous infiltration of the conjunctiva, limbus and sclera who had an exudative retinal detachment, combined ophthalmic artery and central retinal vein occlusion unilaterally. Method: A-53-year old otherwise healthy woman presenting with a painful visual loss in her right eye underwent an ophthalmic examination, meticulous systemic work-up and histopathologic assessment. Results: Ophthalmic examination revealed multiple subconjunctival masses, upper limbal infiltrations, trace cells in the anterior chamber, pale looking posterior fundus, 360 degree scattered retinal hemorrhages and marked exudative retinal detachment in her right eye...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29299082/determination-of-risk-factors-and-treatment-of-dry-eye-disease-in-type-1-diabetes-before-corneal-complications-at-sindh-institute-of-ophthalmology-and-visual-sciences
#3
Shehnilla Shujaat, Muhammad Jawed, Shahzad Memon, Khalid Iqbal Talpur
Objective: The objective of this study was to assess and determine the risk factors and treatment of dry eye disease in type 1 diabetes before any ocular surface or corneal complication occurs. This study was conducted at Sindh Institute of Ophthalmology And Visual Sciences, Hyderabad, Pakistan. Methodology: Subjects and methods for observational study were undertaken at the Department of Ophthalmology Sindh Institute Of Ophthalmology And Visual Sciences, Hyderabad, Pakistan...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29299081/assessment-of-posterior-segment-using-spectral-domain-oct-in-highly-myopic-eyes
#4
Heba Radi AttaAllah, Ismail Ahmed Nagib Omar, Ahmed Shawkat Abdelhalim
Purpose: Spectral Domain Optical Coherence Tomography (SD-OCT) was used to evaluate retinal and vitreo-retinal changes that occur in highly myopic patients. Methods: This prospective study included 472 eyes of 472 patients suffering from high myopia (> -6.00 D), between May 2012 and December 2015. All patients were examined, using Cirrus HD OCT (Zeiss Cirrus TM HD-OCT model 4000), to detect any retinal or vitreo-retinal interface abnormalities.All obtained data was analyzed using Statistical Package for the Social Sciences software version 17 (SPSS Inc, Chicago, IL, USA) and the paired two-sided t-test...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29299080/polypoidal-choroidal-vasculopathy-in-highly-myopic-eyes-with-elongated-axial-length
#5
Gregg T Kokame, Elysse S Tom, Jessica G Shantha, Kyle N Kaneko
Purpose: To retrospectively review the prevalence of myopia and elongated axial length in eyes with polypoidal choroidal vasculopathy (PCV) and to evaluate treatment response of PCV in highly myopic eyes. PCV has rarely been reported in myopic eyes. Methods: A retrospective review of all eyes diagnosed with PCV at the clinics of Retina Consultants of Hawaii and the Hawaii Macula and Retina Institute was performed between February of 2007 and April of 2017 to evaluate for eyes with significant myopia and elongated axial length...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29299079/letter-to-the-editor-bilateral-subconjunctival-hemorrhage-in-a-3-year-old-girl-with-mycoplasma-pneumonia
#6
Tatsuya Mimura, Hidetaka Noma, Satoru Yamagami
We report an unusual case of bilateral subconjunctival hemorrhage following mycoplasma pneumonia. A healthy 3-year-old girl developed bilateral subconjunctival hemorrhage at 4 days after the onset of fever and respiratory symptoms such as running nose, cough, and wheezing. Laboratory data were normal except for elevation of Mycoplasma pneumoniae antibodies. The patient was followed without treatment and the subconjunctival hemorrhage resolved in both eyes within two weeks. To the best of our knowledge, this is the first report of subconjunctival hemorrhage following mycoplasma pneumonia...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29299078/intravitreal-anti-vascular-endothelial-growth-factor-agents-in-the-management-of-retinal-diseases-an-audit
#7
Bassey Fiebai, Victor Odogu
Purpose: The study aimed to describe our initial experience with the use of anti vascular endothelial growth factors (anti-VEGFs) in the treatment of retinal diseases. Methods: The case records of all patients who had received at least 3 doses of intravitreal anti- VEGF injections between January 2012 to December 2016 were reviewed. Information culled from the data was age, sex, indications for treatment, type of injection, presenting visual acuity, post injection visual acuity, systemic and ocular co morbidities...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29299077/a-single-drop-in-the-eye-effects-on-the-whole-body
#8
Anu Vaajanen, Heikki Vapaatalo
Introduction: Although the local adverse effects of ophthalmic drugs, including allergic reactions, are well recognized, less is known about the systemic side- effects of eye drops, especially during pregnancy, breast-feeding and early childhood. Ophthalmologists should also be aware of unusual, in some cases even life-threatening, effects of commonly used eye drops. Conclusion: This brief review outlines the routes of systemic absorption and the kinetics of active components present in eye drops, and identifies the clinically relevant systemic adverse effects...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29299076/presumed-chemotherapy-induced-optic-neuropathy-and-maculopathy-a-case-report
#9
David J Mathew, Anupriya Arthur, Sheeja Susan John
Purpose: With the advent of more aggressive cytotoxic chemotherapy regimens, the incidence of ocular toxicity due to these drugs is also on the rise. We report a case of Presumed Chemotherapy-Induced optic neuropathy and maculopathy secondary to treatment with cytarabine and daunorubicin for Acute Myeloid Leukaemia (AML). Case report: A 50-year-old man with AML developed sudden decrease in vision in his left eye after three cycles of chemotherapy with cytarabine and daunorubicin...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29290882/therapies-for-meibomian-gland-dysfunction-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Kannan Sridharan, Gowri Sivaramakrishnan
Introduction: Meibomian Gland Dysfunction (MGD) is a common, often overlooked, chronic condition affecting eyes for which various therapies are being evaluated. Considering the absence of a systematic review and meta-analysis, the present review was carried out. Methods: An appropriate search strategy eligibility criteria were framed and electronic databases were scrutinized for appropriate literature. Randomized Controlled Trials (RCTs) enrolling patients diagnosed with MGD were included...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29081868/comparison-of-polypropylene-sling-with-combined-transconjunctival-retractor-plication-and-lateral-tarsal-strip-for-correction-of-involutional-lower-eye-lid-ectropion
#11
Ruchi Goel, Abhilasha Sanoria, Sushil Kumar, Deepanjali Arya, Smriti Nagpal, Neha Rathie
PURPOSE: The study aims to compare the effectiveness and complications of transconjunctival retractor plication (TRP) with lateral tarsal strip (LTS) and the polypropylene sling (PS) surgery for treatment of involutional lower lid ectropion. METHOD: A prospective randomised pilot study was conducted on 30 eyes of 30 patients suffering from epiphora having horizontal eyelid laxity >6mm and age >50 years at a tertiary care centre from December 2014 to March 2015...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29081867/ocular-signs-related-to-overweight-and-arterial-hypertension-in-children-a-systematic-review
#12
REVIEW
Daniela S Schuh, Ângela B Piccoli, Raquel L Paiani, Cristiane R Maciel, Lucia C Pellanda, Manuel Ap Vilela
BACKGROUND: The ocular effects of obesity and hypertension need to be established and can be used as prognostic markers. OBJECTIVE: To estimate the prevalence of ophthalmological alterations in children and adolescents who are overweight and/or have SAH. METHODS: The database for this study included all observational studies (CS, cohort, case-control and "baseline" description of randomized clinical trials) with children and/or adolescents who were overweight, obese or had SAH and that measured ophthalmological alterations...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29081866/conventional-versus-accelerated-collagen-cross-linking-for-keratoconus-a-comparison-of-visual-refractive-topographic-and-biomechanical-outcomes
#13
Jyh Haur Woo, Jayant Venkatramani Iyer, Li Lim, M Htoon Hla, Jodhbir S Mehta, Cordelia Ml Chan, Donald Th Tan
OBJECTIVE: The aim was to compare the visual, refractive, topographic and biomechanical outcomes in patients with progressive keratoconus treated with either conventional or accelerated crosslinking at one year follow up. METHODS: It is a prospective, non-randomised interventional study of 76 patients who underwent conventional (CXL; 3mW/cm(2) for 30 minutes) or accelerated cross linking (KXL; 30mW/cm(2) for 4 minutes) for progressive keratoconus. Baseline and postoperative visual acuity, manifest refraction, corneal topography, pachymetry, endothelial cell density and biomechanical parameters of corneal hysteresis and corneal resistance factor were evaluated and compared...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28932341/pathophysiology-of-keratoconus-what-do-we-know-today
#14
Uri Soiberman, James W Foster, Albert S Jun, Shukti Chakravarti
Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28932340/contact-lenses-for-keratoconus-current-practice
#15
Marilita M Moschos, Eirini Nitoda, Panagiotis Georgoudis, Miltos Balidis, Eleftherios Karageorgiadis, Nikos Kozeis
BACKGROUND: Keratoconus is a chronic, bilateral, usuallly asymmetrical, non-inflammatory, ectatic disorder, being characterized by progressive steepening, thinning and apical scarring of the cornea. Initially, the patient is asymptomatic, but the visual acuity gradually decreases, resulting in significant vision loss due to the development of irregular astigmatism, myopia, corneal thinning and scarring. The classic treatment of visual rehabilitation in keratoconus is based on spectacles and contact lenses (CLs)...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28932339/penetrating-keratoplasty-for-keratoconus-excimer-versus-femtosecond-laser-trephination
#16
Berthold Seitz, Achim Langenbucher, Tobias Hager, Edgar Janunts, Moatasem El-Husseiny, Nora Szentmáry
BACKGROUND: In case of keratoconus, rigid gas-permeable contact lenses as the correction method of first choice allow for a good visual acuity for quite some time. In a severe stage of the disease with major cone-shaped protrusion of the cornea, even specially designed keratoconus contact lenses are no more tolerated. In case of existing contraindications for intrastromal ring segments, corneal transplantation typically has a very good prognosis. METHODS: In case of advanced keratoconus - especially after corneal hydrops due to rupture of Descemet's membrane - penetrating keratoplasty (PKP) still is the surgical method of first choice...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28932338/recent-innovations-in-collagen-corneal-cross-linking-a-mini-review
#17
Iraklis Vastardis, Brigitte Pajic-Eggspuehler, Charis Nichorlis, Jörg Mueller, Bojan Pajic
BACKGROUND: The introduction of corneal cross-linking (CXL) with ultraviolet-A (UVA) and Riboflavin photosensitizer (Vit B2) from Seiler et al., revolutionized the treatment of Keratoconus and other corneal ectatic diseases. Today, the commonly known epithelium off Dresden protocol is in clinical use for the last 15 years with great success and regarded by many as the golden standard. METHODS: With several studies demonstrating its simplicity, efficacy and safety this revolutionary method, paved the way for new therapies and strategies in the treatment of corneal ectatic diseases and changed our understanding in corneal biomechanics...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28932337/collagen-cross-linking-for-paediatric-keratoconus
#18
Georgios D Panos, Nikolaos Kozeis, Miltiadis Balidis, Marilita M Moschos, Farhad Hafezi
BACKGROUND: Since the late 1990s corneal crosslinking (CXL) has been proposed as a new treatment option which can stop progression of keratoconus with promising results in adults. OBJECTIVE: Keratoconus presents a higher rate and faster progression in paediatric patients and for this reason prompt and effective treatment is essential. Due to its success in adult keratoconus patients, CXL has been recently applied to children in order to stop or slow progression of keratoconus in paediatric patients...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28932336/genetics-in-keratoconus-what-is-new
#19
Sarah Moussa, Günther Grabner, Josef Ruckhofer, Marie Dietrich, Herbert Reitsamer
BACKGROUND: Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. CONCLUSION: The review focuses on current knowledge of these genetic risk factors associated with keratoconus...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28932335/cataract-surgery-in-patients-with-keratoconus-pearls-and-pitfalls
#20
F Aiello, Q J Nasser, C Nucci, R I Angunawela, Z Gatzioufas, V Maurino
BACKGROUND: Keratoconus (KC) is a common ectatic disorder resulting in progressive corneal thinning and irregular astigmatism. It has been observed that patients affected by KC are more likely to develop lens opacities earlier compared to non-keratoconic patients. OBJECTIVE: Intraocular lens (IOL) selection and refractive outcome prediction are among a number of factors that can make cataract surgery in keratoconic patients challenging. Accurate biometry is often difficult to obtain due to unreliable K measurements and lack of dedicated biometric formulae...
2017: Open Ophthalmology Journal
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