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Open Cardiovascular Medicine Journal

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https://www.readbyqxmd.com/read/29290834/barnidipine-real-life-efficacy-and-tolerability-in-arterial-hypertension-results-from-younger-and-older-patients-in-the-basic-ht-study
#1
Robert Lins, Caroline De Vries
Objective: The aim of this study was to compare the efficacy and tolerability of barnidipine, a strong lipophilic calcium channel blocker, in younger (≤55 for efficacy or <65 years for adverse events) versus older (>55 or ≥65 years) patients with uncomplicated hypertension. Methods: 20,275 patients received barnidipine, 10 or 20 mg/day, as monotherapy or in combination with other antihypertensive drug(s) in the observational BArnidipine real-life Safety and tolerability In Chronic HyperTension (BASIC-HT) study...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29290833/trends-in-stroke-related-mortality-in-the-abc-region-s%C3%A3-o-paulo-brazil-an-ecological-study-between-1997-and-2012
#2
Luiz Vinicius de Alcantara Sousa, Laércio da Silva Paiva, Francisco Winter Dos Santos Figueiredo, Tabata Cristina do Carmo Almeida, Fernando Rocha Oliveira, Fernando Adami
Background: Stroke is the second leading cause of death and the third leading cause of physical disability in the world, with a high burden of morbidity and mortality, but it has been shown a reduction in mortality worldwide over the past two decades, especially in regions with higher income. Objective: The study analyzed the temporal trend and the factors associated with stroke-related mortality in the cities that make up the ABC region of São Paulo (Santo André, São Bernardo do Campo, São Caetano do Sul, Diadema, Mauá, Ribeirão Pires, and Rio Grande da Serra), in comparison to data from the capital city of São Paulo, in the state of São Paulo, Brazil...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29290832/prognostic-assessment-of-diabetics-using-myocardial-perfusion-imaging-diabetes-mellitus-is-still-a-coronary-artery-disease-equivalent
#3
Andrea De Lorenzo, Victor F Souza, Leticia Glerian, Ronaldo Sl Lima
Background: Even though diabetes mellitus (DM) has been considered a "Coronary Artery Disease (CAD) equivalent", that is still controversial, especially in a contemporary population subject to optimized treatment. Objective: We aimed to assess the cardiovascular risk of diabetics by myocardial perfusion scintigraphy (MPS). Methods: Consecutive patients who underwent MPS from 2008 to 2012 were studied. Perfusion scores were calculated, and abnormal MPS was defined as a summed stress score >3...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29204220/impact-of-post-exodontia-bleeding-in-cardiovascular-patients-a-new-classification-proposal
#4
REVIEW
T Lillis, M Didagelos, L Lillis, C Theodoridis, H Karvounis, A Ziakas
Background: Exodontia (dental extraction), being the most frequent minor surgical procedure in the general population, inevitably involves a large number of patients on antithrombotic medication. Current experience shows that there is a degree of confusion in managing these patients. Description: Post-exodontia bleeding, a natural consequence of every dental extraction with no or minor clinical significance in the vast majority of cases, often appears to be of major concern to both patients and healthcare practitioners (dentists or physicians), either because of the alarming nature of oral bleeding itself or because of the distorted perception about its importance...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29204219/validation-of-the-euroscore-ii-in-a-greek-cardiac-surgical-population-a-prospective-study
#5
REVIEW
G Stavridis, D Panaretos, O Kadda, D B Panagiotakos
Objective: The objective of this study was to examine the validity of EuroSCORE II in the Greek population. Methods: A prospective single-center study was performed during November 1, 2013 and November 5, 2016; 621 patients undergoing cardiac surgery were enrolled. The EuroSCORE II values and the actual mortality of the patients were recorded in a special database. Calibration of the model was evaluated with the Hosmer-Lemeshow goodness-of-fit test, and discrimination with the areas under the receiver operating characteristic (ROC) curve...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29204218/interpreting-the-mechanism-of-apoe-p-leu167del-mutation-in-the-incidence-of-familial-hypercholesterolemia-an-in-silico-approach
#6
REVIEW
Omran Mohammed Rashidi, Fatima Amanullah H Nazar, Mohamed Nabil Alama, Zuhier Ahmed Awan
Background: Apolipoprotein E (APOE) gene is a ligand protein in humans which mediates the metabolism of cholesterol by binding to the low-density lipoprotein receptor (LDLR). P.Leu167del mutation in APOE gene was recently connected with Familial Hypercholesterolemia, a condition associated with premature cardiovascular disease. The consequences of this mutation on the protein structure and its receptor binding capacity remain largely unknown. Objective: The current study aims to further decipher the underlying mechanism of this mutation using advanced software-based algorithms...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28868092/the-spectrum-of-familial-hypercholesterolemia-fh-in-saudi-arabia-prime-time-for-patient-fh-registry
#7
REVIEW
Faisal Alallaf, Fatima Amanullah H Nazar, Majed Alnefaie, Adel Almaymuni, Omran Mohammed Rashidi, Khalid Alhabib, Fahad Alnouri, Mohamed-Nabil Alama, Mohammad Athar, Zuhier Awan
BACKGROUND: Familial hypercholesterolemia (FH) is a life-threatening inherited condition. Untreated patients have the risk to develop raised plasma levels of cholesterol, atherosclerosis and cardiovascular disease (CVD). If diagnosed and treated early in life, the pathological consequences due to atherosclerosis could be avoided and patients with FH can have an anticipated normal life. Mounting evidence suggests that FH is underdiagnosed and undertreated in all populations. The underlying molecular basis of FH is the presence of mutations in one or more genes in the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or proprotein convertase subtilisin/kexin 9 (PCSK9)...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28761561/coronary-perforation-of-distal-diagonal-branch-followed-by-prolonged-recurrent-cardiac-tamponade-finally-resolved-with-pericardiotomy-the-potential-risk-of-hydrophilic-guide-wires
#8
Rafał Januszek, Krzysztof Bartuś, Radosław Litwinowicz, Artur Dziewierz, Łukasz Rzeszutko
PURPOSE: Coronary artery perforation (CAP) is a complication of percutaneous coronary interventions (PCIs). Hydrophilic guide-wires have been shown to increase the probability of CAP. Depending on the size of perforations we adopt different treatments. CASE: We present the case of a 73-year old male with coronary artery disease and severe aortic valve stenosis. The patient was in the process of qualifying for a transcatheter aortic valve implantation. Unfortunately, CAP of the first diagonal branch of the LAD occurred during PCI...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28572865/electrocardiographic-changes-after-suicidal-digoxin-intoxication-in-a-healthy-woman
#9
Natalia Lorenzo Muñoz, Amparo Benedicto Buendía, Fernando Alfonso Manterola
BACKGROUND: Suicidal digoxin intoxication is a rare clinical entity. Clinical suspicious remains of paramount importance as adequate interpretation of the electrocardiographic changes enable to readily initiate treatment. METHOD: We describe a case of suicidal attempt after massive digoxin intake that was satisfactory managed with conservative management strategy that involved a close clinical surveillance of the evolving electrocardiographic changes and digoxin serum levels...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28567132/nitric-oxide-and-related-aspects-underlying-angina
#10
REVIEW
Carolina Baraldi Araujo Restini, Leticia Gonçalves
Increased number of patients affected by metabolic syndrome (MS) has prompted the necessity of better understanding what is involved in such syndrome. Nevertheless, the establishment of promising therapies depends on the knowledge about the interaction of molecules within MS. In such context, Nitric Oxide (NO) emerges from a bulk of works relating its roles on aspects of MS, including cardiovascular diseases, their symptoms and comorbidities, which are thought to be triggered by similar sources. NO, nitric oxide synthase and enzymatic chains are keys for those disease and symptoms processes...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28567131/the-predictive-value-of-the-syntax-score-in-patients-with-chronic-coronary-artery-disease-undergoing-percutaneous-coronary-intervention-or-coronary-artery-bypass-grafting-a-pilot-study
#11
K Papadopoulos, I Lekakis, E Nicolaides
OBJECTIVES: To evaluate the usefulness of the SYNTAX score (SS) in predicting 1-year clinical outcomes in a population of patients with chronic coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). BACKGROUND: Despite the proven prognostic value of the SS in patients with multivessel and/or left main (LM) CAD, its usefulness in other patient subsets remains uncertain. METHODS: This was a prospective single centre cohort study conducted from September 2012 to November 2014 at the Nicosia General Hospital, Cyprus...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28553410/socioeconomic-factors-and-severity-of-coronary-artery-disease-in-patients-undergoing-coronary-angiography-a-multicentre-study-of-arabian-gulf-states
#12
Amin Daoulah, Osama E Elkhateeb, S Ali Nasseri, Mushabab Al-Murayeh, Salem Al-Kaabi, Amir Lotfi, Mohamed N Alama, Salem M Al-Faifi, Mamdouh Haddara, Ciaran M Dixon, Ibrahim S Alzahrani, Abdullah A Alghamdi, Waleed Ahmed, Adnan Fathey, Ejazul Haq, Alawi A Alsheikh-Ali
INTRODUCTION: Coronary artery disease (CAD) is a leading cause of death worldwide. The association of socioeconomic status with CAD is supported by numerous epidemiological studies. Whether such factors also impact the number of diseased coronary vessels and its severity is not well established. MATERIALS AND METHODS: We conducted a prospective multicentre, multi-ethnic, cross sectional observational study of consecutive patients undergoing coronary angiography (CAG) at 5 hospitals in the Kingdom of Saudi Arabia and the United Arab Emirates...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28400862/an-audit-of-clinical-practice-in-a-single-centre-in-kuwait-management-of-children-on-continuous-subcutaneous-insulin-infusion-and-cardiovascular-risk-factors-screening
#13
Dina Omar, Hala Alsanae, Mona Al Khawari, Majedah Abdulrasoul, Zahraa Rahme, Faisal Al Refaei, Kazem Behbehani, Azza Shaltout
OBJECTIVES: To audit the current clinical practice of continuous subcutaneous insulin infusion (CSII) for the treatment of type 1 diabetes mellitus (T1D) in children and adolescents attending a single centre in Kuwait. METHODS: A one year retrospective audit was performed in children and adolescents with T1D on CSII, who attended the paediatric diabetes clinic, Dasman Diabetes Institute during 2012. The primary outcome measure was glycaemic control as evidenced by glycated haemoglobin (HbA1c) level and the secondary outcome measures were the frequency of monitoring of the risk for microvascular complications and occurrence of acute complications and adverse events...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28400861/revision-of-echocardiographic-indications-and-findings-in-neurologically-ill-patients
#14
Claudia Stöllberger, Christian Wegner, Josef Finsterer
BACKGROUND AND OBJECTIVE: Little is known about the general indications for echocardiography and the prevalence of abnormalities detected by echocardiography in patients who are referred from a neurological department. Left ventricular hypertrabeculation/noncompaction (LVHT) is associated with neuromuscular disorders and embolism. The aim of the study was to assess the indications for echocardiography in patients from a neurological department and to review the cine-loops of the examinations in order to assess the frequency of abnormal echocardiographic findings with special regard to LVHT...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28217180/hypoxic-pulmonary-vasoconstriction-in-humans-tale-or-myth
#15
REVIEW
A Hussain, M S Suleiman, S J George, M Loubani, A Morice
Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28217179/does-body-mass-index-affect-mortality-in-coronary-surgery
#16
Aristotle D Protopapas
INTRODUCTION: The Body Mass Index (BMI) quantifies nutritional status and classifies humans as underweight, of normal weight, overweight, mildly obese, moderately obese or morbidly obese. Obesity is the excessive accumulation of fat, defined as BMI higher than 30 kg/m(2). Obesity is widely accepted to complicate anaesthesia and surgery, being a risk factor for mediastinitis after coronary artery bypass grafting (CABG). We sought the evidence on operative mortality of CABG between standard BMI groups...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27990182/effect-of-atp-binding-cassette-transporter-a1-abca1-gene-polymorphisms-on-plasma-lipid-variables-and-common-demographic-parameters-in-greek-nurses
#17
Vana Kolovou, Apostolia Marvaki, Maria Boutsikou, Georgios Vasilopoulos, Dimitrios Degiannis, Christina Marvaki, Genovefa Kolovou
OBJECTIVE: The present study is on line with our previous studies evaluating the influence of ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms on the lipid variables of Greek student-nurses. The current study was undertaken to (1) estimate the influence of variant(s) such as rs2066715 (V825I), R219K, R1587K, I883M of ABCA1 gene on lipid variables and (2) evaluate the effect of all four ABCA1 polymorphisms on common demographic parameters. METHODS: The study population involved 432 unrelated nurses (86 men) who were genotyped for ABCA1 polymorphisms and correlated according to lipid variables [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] and demographic parameters (age, gender, BMI, waist circumference)...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27990181/risk-of-cerebral-embolization-with-caseous-calcification-of-the-mitral-annulus-review-article
#18
Charles A Dietl, Christopher M Hawthorn, Veena Raizada
BACKGROUND: Caseous calcification of the mitral annulus (CCMA) is believed to have a benign prognosis. Several authors have recommended conservative management in asymptomatic patients. However, the prevalence of cerebrovascular events (CVE) in patients with CCMA has never been evaluated before. The aims of this study are to investigate whether patients with CCMA are at increased risk of cerebral embolization, and to determine whether elective surgical resection of CCMA should be considered to prevent a cardioembolic stroke...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27867429/correlation-between-diastolic-function-and-endothelial-function-in-patients-with-type-2-diabetes-and-hypertension
#19
Ricardo Bedirian, Mario Fritsch Neves, Wille Oigman, Ronaldo Altenburg Odebrecht Curi Gismondi, Cesar Romaro Pozzobon, Marcia Cristina Boaventura Ladeira, Marcia Bueno Castier
BACKGROUND: Endothelial dysfunction may be involved in the pathophysiology of cardiac abnormalities in patients with diabetes mellitus (DM). A correlation between endothelial dysfunction and diastolic dysfunction in patients with type 1 DM has been demonstrated, but this relationship has not been well investigated in type 2 DM. OBJECTIVE: Compare groups of patients with type 2 DM and hypertension with and without diastolic dysfunction using endothelial function indexes, and to assess whether correlations exist between the diastolic function and the endothelial function indexes...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27733870/chest-pain-of-uncertain-aetiology-role-of-contrast-enhanced-computed-tomography-in-the-emergency-department
#20
Firas Yassin, Chris Sawh, Pankaj Garg
There is increasing role of computed tomographic (CT) in the assessment of acute chest pain in the emergency department especially when the diagnosis is not clear. We report a case where non ECG gated contrast enhanced CT in the emergency department for rule-out of pulmonary embolus guided to the actual diagnosis, which was, acute coronary event, as evidenced by the presence of perfusion defect.
2016: Open Cardiovascular Medicine Journal
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