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Open Cardiovascular Medicine Journal

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https://www.readbyqxmd.com/read/27867429/correlation-between-diastolic-function-and-endothelial-function-in-patients-with-type-2-diabetes-and-hypertension
#1
Ricardo Bedirian, Mario Fritsch Neves, Wille Oigman, Ronaldo Altenburg Odebrecht Curi Gismondi, Cesar Romaro Pozzobon, Marcia Cristina Boaventura Ladeira, Marcia Bueno Castier
BACKGROUND: Endothelial dysfunction may be involved in the pathophysiology of cardiac abnormalities in patients with diabetes mellitus (DM). A correlation between endothelial dysfunction and diastolic dysfunction in patients with type 1 DM has been demonstrated, but this relationship has not been well investigated in type 2 DM. OBJECTIVE: Compare groups of patients with type 2 DM and hypertension with and without diastolic dysfunction using endothelial function indexes, and to assess whether correlations exist between the diastolic function and the endothelial function indexes...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27733870/chest-pain-of-uncertain-aetiology-role-of-contrast-enhanced-computed-tomography-in-the-emergency-department
#2
Firas Yassin, Chris Sawh, Pankaj Garg
There is increasing role of computed tomographic (CT) in the assessment of acute chest pain in the emergency department especially when the diagnosis is not clear. We report a case where non ECG gated contrast enhanced CT in the emergency department for rule-out of pulmonary embolus guided to the actual diagnosis, which was, acute coronary event, as evidenced by the presence of perfusion defect.
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27733869/life-threatening-rupture-of-a-femoral-pseudoaneurysm-after-cardiac-catheterization
#3
Emmanouil Petrou, Ioannis Malakos, Stamatina Kampanarou, Nikolaos Doulas, Vassilis Voudris
A pseudoaneurysm refers to a defect in the arterial wall, allowing communication of arterial blood with the adjacent extra-luminal space. Pseudoaneurysms result from traumatic arterial injury. With the increasing utilization of percutaneous arterial interventions, iatrogenic arterial injury has become the predominant cause of pseudoaneurysm formation. Rupture of the pseudoaneurysm comprises a vascular emergency. Clinical suspicion and imaging techniques are the cornerstones of timely diagnosis and appropriate management of the condition...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27733868/insights-in-hypothesis-testing-and-making-decisions-in-biomedical-research
#4
Varin Sacha, Demosthenes B Panagiotakos
It is a fact that p values are commonly used for inference in biomedical and other social fields of research. Unfortunately, the role of p value is very often misused and misinterpreted; that is why it has been recommended the use of resampling methods, like the bootstrap method, to calculate the confidence interval, which provides more robust results for inference than does p value. In this review a discussion is made about the use of p values through hypothesis testing and its alternatives using resampling methods to develop confidence intervals of the tested statistic or effect measure...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27651842/pulse-wave-analysis-by-applanation-tonometry-for-the-measurement-of-arterial-stiffness
#5
John Doupis, Nikolaos Papanas, Alison Cohen, Lyndsay McFarlan, Edward Horton
The aim of our study was to investigate the association between pulse wave velocity (PWV) and pulse wave analysis (PWA)-derived measurements for the evaluation of arterial stiffness. A total of 20 (7 male and 13 female) healthy, non-smoking individuals, with mean age 31 ± 12years were included. PWV and PWA measurements were performed using a SphygmoCor apparatus (Atcor Medical Blood Pressure Analysis System, Sydney Australia). PWV significantly correlated with all central aortic haemodynamic parameters, especially with pulse pressure (PP) (p < 0...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27651841/the-current-indication-for-pacemaker-in-patients-with-cardioinhibitory-vasovagal-syncope
#6
Rose Mary Ferreira Lisboa da Silva
The most frequent cause of syncope is vasovagal reflex. It is associated with worse quality of life, depression, fatigue and physical injury. Recurrence of vasovagal syncope is an aggravating, reaching the rate of 69%. Initial step and pharmacological treatment may not work, especially in patients with recurrent syncope without prodrome. These patients can present cardioinhibitory response with asystole. Studies were designed to analyses the effectiveness of pacemaker for prevention of syncope. In this review, nonrandomized clinical trials, open-label randomized, double-blind randomized, placebo-controlled, and studies based on tilt test or Implantable Loop Recorder findings will be discussed...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27583042/comparison-of-the-effects-of-dialysis-methods-haemodialysis-vs-peritoneal-dialysis-on-diastolic-left-ventricular-function-dialysis-methods-and-diastolic-function
#7
Fedoua Ellouali, Fatimazahra Berkchi, Rabia Bayahia, Loubna Benamar, Mohammed Cherti
INTRODUCTION: In patients undergoing chronic dialysis, several factors appear to influence the occurrence of cardiac abnormalities. The aim of our study was to evaluate the effects of two different methods of renal replacement therapy (chronic haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD)) on left ventricular (LV) diastolic function. PATIENTS AND METHODS: We enrolled 63 patients: 21 patients on CAPD, and 42 age- and gender-matched patients on HD; 35 patients were men (55...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27583041/initial-experience-with-renal-denervation-for-the-treatment-of-resistant-hypertension-the-utility-of-novel-anesthetics-and-metaiodobenzylguanidine-scintigraphy-mibg
#8
Antonios Ziakas, Dimitrios Petroglou, Efstratios Moralidis, Konstantinos Tsioufis, Mihalis Doumas, Elena Argiriadou, Christos Savopoulos, Stavros Hadjimiltiades, Ioannis Stiliadis, Antonios Kouparanis, Sotirios Katranas, Leonidas Lillis, Athanasios Koutsakis, Haralambos Karvounis
BACKGROUND: The Symplicity-HTN 3 trial failed to show significant difference in blood pressure (BP) lowering between patients undergoing catheter-based renal denervation (RDN) and the sham-procedure arm of the study. However, there is still optimism about the role of RDN in the treatment of resistant hypertension, because identification of patients with increased sympathetic activity thus being good RDN responders, improvements in the RDN procedure and new technology RDN catheters are all expected to lead to better RDN results...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27583040/impaired-myocardial-bioenergetics-in-hfpef-and-the-role-of-antioxidants
#9
John B Hiebert, Qiuhua Shen, Amanda Thimmesch, Janet Pierce
Heart failure with preserved ejection fraction (HFpEF) is a significant cardiovascular condition for more than 50% of patients with heart failure. Currently, there is no effective treatment to decrease morbidity and mortality rates associated with HFpEF because of its pathophysiological heterogeneity. Recent evidence shows that deficiency in myocardial bioenergetics is one of the key pathophysiological factors contributing to diastolic dysfunction in HFpEF. Another known mechanism for HFpEF is an overproduction of free radicals, specifically reactive oxygen species...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27583039/the-effects-of-levosimendan-and-sodium-nitroprusside-combination-on-left-ventricular-functions-after-surgical-ventricular-reconstruction-in-coronary-artery-bypass-grafting-patients
#10
Zeki Temizturk, Davut Azboy, Atakan Atalay, Hakan Atalay, Omer Faruk Dogan
OBJECTIVE: The aim of our study was to research the effects of levosimendan (LS) and sodium nitroprusside (SNP) combination on systolic and diastolic ventricular function after coronary artery bypass grafting (CABG) who required endoventricular patch repair (EVPR). PATIENTS AND METHODS: We studied 70 patients with ischemic dilated cardiomyopathy. LS and SNP combination was administered in 35 patients (study group, SG). In the remaining patients, normal saline solution was given (placebo group, PG)...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27583038/heparin-versus-bivalirudin-in-acute-myocardial-infarction-unfractionated-heparin-monotherapy-elevated-to-primary-treatment-in-contemporary-percutaneous-coronary-intervention
#11
Osmar Antonio Centurión
Bivalirudin, a direct thrombin inhibitor, was developed as an antithrombin agent for patients undergoing percutaneous coronary interventions (PCI) with the hypothesis that it would reduce bleeding complications without compromising the rate of ischemic events compared to heparin plus GP IIb/IIIa inhibitors. Although the cumulative evidence makes a strong argument for the use of bivalirudin rather than heparin plus systematic GP IIb/IIIa inhibitors for the great majority of patients with acute myocardial infarction (AMI) undergoing PCI, the benefit observed with bivalirudin was achieved because of the major bleeding complications with the use of heparin plus GP IIb/IIIa inhibitors...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27499818/allogeneic-blood-product-usage-in-coronary-artery-bypass-grafting-cabg-with-minimalized-extracorporeal-circulation-system-mecc-versus-standard-on-pump-coronary-artery-bypass-grafting
#12
M Lisy, E Schmid, J Kozok, P Rosenberger, U A Stock, G Kalender
AIM: Intraoperative allogeneic blood product transfusion (ABPT) in cardiac surgery is associated with worse overall outcome, including mortality. The objective of this study was to evaluate the ABPTs in minimalized extracorporeal cardiopulmonary (MECC(TM)) compared with standard open system on-pump coronary revascularization. METHODS: Data of 156 patients undergoing myocardial revascularization between September 2008 and September 2010 were reviewed. 83 patients were operated by the MECC technique and 73 were treated by standard extracorporeal circulation (sECC)...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27499817/cardiac-dual-source-computed-tomography-for-the-detection-of-left-main-compression-syndrome-in-patients-with-pulmonary-hyper-tension
#13
Eftychia Demerouti, Athanassios Manginas, Emmanouil Petrou, Spyridoula Katsilouli, Panagiotis Karyofillis, George Athanassopoulos, George Karatasakis, Ioannis Iakovou, Konstantinos Mihas, Irene Mastorakou
INTRODUCTION: Left Main Compression Syndrome (LMCS) represents an entity described as the extrinsic compression of the left main coronary artery (LMCA) by a dilated pulmonary artery (PA) trunk. We examined the presence of LMCS in patients with pulmonary hypertension (PH) using dual-source computed tomography (DSCT), as a non-invasive diagnostic tool. METHODS: The following parameters were measured: PA trunk diameter (PAD), the distance between PAD and LMCA (LMPA) and the distance between PA and aorta (AoPA)...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27429668/prevalence-of-major-cardiovascular-risk-factors-and-coronary-heart-disease-in-a-sample-of-greek-adults-the-saronikos-study
#14
Aristofanis Gikas, Vaia Lambadiari, Alexios Sotiropoulos, Demosthenes Panagiotakos, Stavros Pappas
BACKGROUND: Comprehensive data regarding prevalence of coronary heart disease (CHD) and associated factors in different geographical regions are very important to our understanding of global distribution and evolution of CHD. The aim of this study was to assess the current prevalence of self-reported risk factors and CHD in Greek adult population. METHODS: A community-based cross-sectional study was conducted in May 2014, during an election day, among residents of Saronikos municipality (Attica region)...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27347229/association-between-ace-gene-polymorphism-and-qt-dispersion-in-patients-with-acute-myocardial-infarction
#15
Zulkuf Karahan, Murat Ugurlu, Berzal Ucaman, Ali Veysel Ulug, Ilyas Kaya, Kemal Cevik, Mehmet Sahin Adiyaman, Onder Oztürk, Hikmet Iyem, Ferit Ozdemir
BACKGROUND: Angiotensin converting enzyme (ACE) gene polymorphism is associated with high renin-angiotensin system causing myocardial fibrosis and ventricular repolarization abnormality. Based on these findings, this study was designed to determine the association between ACE gene insertion/deletion (I/D) polymorphism and QT dispersion after acute myocardial infarction (MI). OBJECTIVE AND METHODS: The study included 108 patients with acute MI. Blood samples were obtained from all the patients for genomic DNA analysis...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27347228/stroke-prevention-in-atrial-fibrillation-and-valvular-heart-disease
#16
Saad Ahmad, Heath Wilt
There is a clinically staggering burden of disease stemming from cerebrovascular events, of which a majority are ischemic in nature and many are precipitated by atrial fibrillation (AF). AF can occur in isolation or in association with myocardial or structural heart disease. In the latter case, and when considering health at an international level, congenital and acquired valve-related diseases are frequent contributors to the current pandemic of AF and its clinical impact. Guidelines crafted by the American Heart Association, American College of Cardiology, European Society of Cardiology and Heart Rhythm Society underscore the use of vitamin K antagonists (VKAs) among patients with valvular heart disease, particularly in the presence of concomitant AF, to reduce the risk of ischemic stroke of cardioembolic origin; however, the non-VKAs, also referred to as direct, target-specific or new oral anticoagulants (NOACs), have not been actively studied in this particular population...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27347227/ictal-cardiac-ryhthym-abnormalities
#17
Rushna Ali
Cardiac rhythm abnormalities in the context of epilepsy are a well-known phenomenon. However, they are under-recognized and often missed. The pathophysiology of these events is unclear. Bradycardia and asystole are preceded by seizure onset suggesting ictal propagation into the cortex impacting cardiac autonomic function, and the insula and amygdala being possible culprits. Sudden unexpected death in epilepsy (SUDEP) refers to the unanticipated death of a patient with epilepsy not related to status epilepticus, trauma, drowning, or suicide...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27347226/newer-oral-anticoagulants-stroke-prevention-and-pitfalls
#18
Anand Patel, Richard P Goddeau, Nils Henninger
Warfarin is very effective in preventing stroke in patients with atrial fibrillation. However, its use is limited due to fear of hemorrhagic complications, unpredictable anticoagulant effects related to multiple drug interactions and dietary restrictions, a narrow therapeutic window, frequent difficulty maintaining the anticoagulant effect within a narrow therapeutic window, and the need for inconvenient monitoring. Several newer oral anticoagulants have been approved for primary and secondary prevention of stroke in patients with non-valvular atrial fibrillation...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27347225/long-term-arrhythmia-monitoring-in-cryptogenic-stroke-who-how-and-for-how-long
#19
Mayra Montalvo, Rushna Ali, Brian Silver, Muhib Khan
Cryptogenic stroke and transient ischemic attack (TIA) account for approximately one-third of stroke patients [1]. Paroxys-mal atrial fibrillation (PAF) has been suggested as a major etiology of these cryptogenic strokes [2, 3]. PAF can be difficult to diagnose because it is intermittent, often brief, and asymptomatic. PAF might be more prevalent than persistent atrial fibrillation in stroke and TIA patients, especially in younger populations [4, 5]. In patients with atrial fibrillation, anticoagulation provides significant risk reduction [6]...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27347224/an-overview-of-cardiac-management-in-neuromuscular-disease
#20
Renee M Hickey, John D Cullen, George M Sachs
Muscular dystrophy and myasthenia gravis are two neuromuscular disorders that can involve significant cardiovascular complications. The frequency and severity of cardiac pathology varies widely among the muscular dystrophies. In some, it is nearly inevitable and requires regular evaluation. In others, assessment of cardiac function can be more symptom-driven. On-ly a minority of myasthenic patients manifest disease-related cardiovascular complications; however, their presentation can be rapidly progressive and life-threatening...
2016: Open Cardiovascular Medicine Journal
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