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Open Cardiovascular Medicine Journal

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https://www.readbyqxmd.com/read/28572865/electrocardiographic-changes-after-suicidal-digoxin-intoxication-in-a-healthy-woman
#1
Natalia Lorenzo Muñoz, Amparo Benedicto Buendía, Fernando Alfonso Manterola
BACKGROUND: Suicidal digoxin intoxication is a rare clinical entity. Clinical suspicious remains of paramount importance as adequate interpretation of the electrocardiographic changes enable to readily initiate treatment. METHOD: We describe a case of suicidal attempt after massive digoxin intake that was satisfactory managed with conservative management strategy that involved a close clinical surveillance of the evolving electrocardiographic changes and digoxin serum levels...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28567132/nitric-oxide-and-related-aspects-underlying-angina
#2
REVIEW
Carolina Baraldi Araujo Restini, Leticia Gonçalves
Increased number of patients affected by metabolic syndrome (MS) has prompted the necessity of better understanding what is involved in such syndrome. Nevertheless, the establishment of promising therapies depends on the knowledge about the interaction of molecules within MS. In such context, Nitric Oxide (NO) emerges from a bulk of works relating its roles on aspects of MS, including cardiovascular diseases, their symptoms and comorbidities, which are thought to be triggered by similar sources. NO, nitric oxide synthase and enzymatic chains are keys for those disease and symptoms processes...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28567131/the-predictive-value-of-the-syntax-score-in-patients-with-chronic-coronary-artery-disease-undergoing-percutaneous-coronary-intervention-or-coronary-artery-bypass-grafting-a-pilot-study
#3
K Papadopoulos, I Lekakis, E Nicolaides
OBJECTIVES: To evaluate the usefulness of the SYNTAX score (SS) in predicting 1-year clinical outcomes in a population of patients with chronic coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). BACKGROUND: Despite the proven prognostic value of the SS in patients with multivessel and/or left main (LM) CAD, its usefulness in other patient subsets remains uncertain. METHODS: This was a prospective single centre cohort study conducted from September 2012 to November 2014 at the Nicosia General Hospital, Cyprus...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28553410/socioeconomic-factors-and-severity-of-coronary-artery-disease-in-patients-undergoing-coronary-angiography-a-multicentre-study-of-arabian-gulf-states
#4
Amin Daoulah, Osama E Elkhateeb, S Ali Nasseri, Mushabab Al-Murayeh, Salem Al-Kaabi, Amir Lotfi, Mohamed N Alama, Salem M Al-Faifi, Mamdouh Haddara, Ciaran M Dixon, Ibrahim S Alzahrani, Abdullah A Alghamdi, Waleed Ahmed, Adnan Fathey, Ejazul Haq, Alawi A Alsheikh-Ali
INTRODUCTION: Coronary artery disease (CAD) is a leading cause of death worldwide. The association of socioeconomic status with CAD is supported by numerous epidemiological studies. Whether such factors also impact the number of diseased coronary vessels and its severity is not well established. MATERIALS AND METHODS: We conducted a prospective multicentre, multi-ethnic, cross sectional observational study of consecutive patients undergoing coronary angiography (CAG) at 5 hospitals in the Kingdom of Saudi Arabia and the United Arab Emirates...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28400862/an-audit-of-clinical-practice-in-a-single-centre-in-kuwait-management-of-children-on-continuous-subcutaneous-insulin-infusion-and-cardiovascular-risk-factors-screening
#5
Dina Omar, Hala Alsanae, Mona Al Khawari, Majedah Abdulrasoul, Zahraa Rahme, Faisal Al Refaei, Kazem Behbehani, Azza Shaltout
OBJECTIVES: To audit the current clinical practice of continuous subcutaneous insulin infusion (CSII) for the treatment of type 1 diabetes mellitus (T1D) in children and adolescents attending a single centre in Kuwait. METHODS: A one year retrospective audit was performed in children and adolescents with T1D on CSII, who attended the paediatric diabetes clinic, Dasman Diabetes Institute during 2012. The primary outcome measure was glycaemic control as evidenced by glycated haemoglobin (HbA1c) level and the secondary outcome measures were the frequency of monitoring of the risk for microvascular complications and occurrence of acute complications and adverse events...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28400861/revision-of-echocardiographic-indications-and-findings-in-neurologically-ill-patients
#6
Claudia Stöllberger, Christian Wegner, Josef Finsterer
BACKGROUND AND OBJECTIVE: Little is known about the general indications for echocardiography and the prevalence of abnormalities detected by echocardiography in patients who are referred from a neurological department. Left ventricular hypertrabeculation/noncompaction (LVHT) is associated with neuromuscular disorders and embolism. The aim of the study was to assess the indications for echocardiography in patients from a neurological department and to review the cine-loops of the examinations in order to assess the frequency of abnormal echocardiographic findings with special regard to LVHT...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28217180/hypoxic-pulmonary-vasoconstriction-in-humans-tale-or-myth
#7
REVIEW
A Hussain, M S Suleiman, S J George, M Loubani, A Morice
Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28217179/does-body-mass-index-affect-mortality-in-coronary-surgery
#8
Aristotle D Protopapas
INTRODUCTION: The Body Mass Index (BMI) quantifies nutritional status and classifies humans as underweight, of normal weight, overweight, mildly obese, moderately obese or morbidly obese. Obesity is the excessive accumulation of fat, defined as BMI higher than 30 kg/m(2). Obesity is widely accepted to complicate anaesthesia and surgery, being a risk factor for mediastinitis after coronary artery bypass grafting (CABG). We sought the evidence on operative mortality of CABG between standard BMI groups...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27990182/effect-of-atp-binding-cassette-transporter-a1-abca1-gene-polymorphisms-on-plasma-lipid-variables-and-common-demographic-parameters-in-greek-nurses
#9
Vana Kolovou, Apostolia Marvaki, Maria Boutsikou, Georgios Vasilopoulos, Dimitrios Degiannis, Christina Marvaki, Genovefa Kolovou
OBJECTIVE: The present study is on line with our previous studies evaluating the influence of ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms on the lipid variables of Greek student-nurses. The current study was undertaken to (1) estimate the influence of variant(s) such as rs2066715 (V825I), R219K, R1587K, I883M of ABCA1 gene on lipid variables and (2) evaluate the effect of all four ABCA1 polymorphisms on common demographic parameters. METHODS: The study population involved 432 unrelated nurses (86 men) who were genotyped for ABCA1 polymorphisms and correlated according to lipid variables [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] and demographic parameters (age, gender, BMI, waist circumference)...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27990181/risk-of-cerebral-embolization-with-caseous-calcification-of-the-mitral-annulus-review-article
#10
Charles A Dietl, Christopher M Hawthorn, Veena Raizada
BACKGROUND: Caseous calcification of the mitral annulus (CCMA) is believed to have a benign prognosis. Several authors have recommended conservative management in asymptomatic patients. However, the prevalence of cerebrovascular events (CVE) in patients with CCMA has never been evaluated before. The aims of this study are to investigate whether patients with CCMA are at increased risk of cerebral embolization, and to determine whether elective surgical resection of CCMA should be considered to prevent a cardioembolic stroke...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27867429/correlation-between-diastolic-function-and-endothelial-function-in-patients-with-type-2-diabetes-and-hypertension
#11
Ricardo Bedirian, Mario Fritsch Neves, Wille Oigman, Ronaldo Altenburg Odebrecht Curi Gismondi, Cesar Romaro Pozzobon, Marcia Cristina Boaventura Ladeira, Marcia Bueno Castier
BACKGROUND: Endothelial dysfunction may be involved in the pathophysiology of cardiac abnormalities in patients with diabetes mellitus (DM). A correlation between endothelial dysfunction and diastolic dysfunction in patients with type 1 DM has been demonstrated, but this relationship has not been well investigated in type 2 DM. OBJECTIVE: Compare groups of patients with type 2 DM and hypertension with and without diastolic dysfunction using endothelial function indexes, and to assess whether correlations exist between the diastolic function and the endothelial function indexes...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27733870/chest-pain-of-uncertain-aetiology-role-of-contrast-enhanced-computed-tomography-in-the-emergency-department
#12
Firas Yassin, Chris Sawh, Pankaj Garg
There is increasing role of computed tomographic (CT) in the assessment of acute chest pain in the emergency department especially when the diagnosis is not clear. We report a case where non ECG gated contrast enhanced CT in the emergency department for rule-out of pulmonary embolus guided to the actual diagnosis, which was, acute coronary event, as evidenced by the presence of perfusion defect.
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27733869/life-threatening-rupture-of-a-femoral-pseudoaneurysm-after-cardiac-catheterization
#13
Emmanouil Petrou, Ioannis Malakos, Stamatina Kampanarou, Nikolaos Doulas, Vassilis Voudris
A pseudoaneurysm refers to a defect in the arterial wall, allowing communication of arterial blood with the adjacent extra-luminal space. Pseudoaneurysms result from traumatic arterial injury. With the increasing utilization of percutaneous arterial interventions, iatrogenic arterial injury has become the predominant cause of pseudoaneurysm formation. Rupture of the pseudoaneurysm comprises a vascular emergency. Clinical suspicion and imaging techniques are the cornerstones of timely diagnosis and appropriate management of the condition...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27733868/insights-in-hypothesis-testing-and-making-decisions-in-biomedical-research
#14
Varin Sacha, Demosthenes B Panagiotakos
It is a fact that p values are commonly used for inference in biomedical and other social fields of research. Unfortunately, the role of p value is very often misused and misinterpreted; that is why it has been recommended the use of resampling methods, like the bootstrap method, to calculate the confidence interval, which provides more robust results for inference than does p value. In this review a discussion is made about the use of p values through hypothesis testing and its alternatives using resampling methods to develop confidence intervals of the tested statistic or effect measure...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27651842/pulse-wave-analysis-by-applanation-tonometry-for-the-measurement-of-arterial-stiffness
#15
John Doupis, Nikolaos Papanas, Alison Cohen, Lyndsay McFarlan, Edward Horton
The aim of our study was to investigate the association between pulse wave velocity (PWV) and pulse wave analysis (PWA)-derived measurements for the evaluation of arterial stiffness. A total of 20 (7 male and 13 female) healthy, non-smoking individuals, with mean age 31 ± 12years were included. PWV and PWA measurements were performed using a SphygmoCor apparatus (Atcor Medical Blood Pressure Analysis System, Sydney Australia). PWV significantly correlated with all central aortic haemodynamic parameters, especially with pulse pressure (PP) (p < 0...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27651841/the-current-indication-for-pacemaker-in-patients-with-cardioinhibitory-vasovagal-syncope
#16
Rose Mary Ferreira Lisboa da Silva
The most frequent cause of syncope is vasovagal reflex. It is associated with worse quality of life, depression, fatigue and physical injury. Recurrence of vasovagal syncope is an aggravating, reaching the rate of 69%. Initial step and pharmacological treatment may not work, especially in patients with recurrent syncope without prodrome. These patients can present cardioinhibitory response with asystole. Studies were designed to analyses the effectiveness of pacemaker for prevention of syncope. In this review, nonrandomized clinical trials, open-label randomized, double-blind randomized, placebo-controlled, and studies based on tilt test or Implantable Loop Recorder findings will be discussed...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27583042/comparison-of-the-effects-of-dialysis-methods-haemodialysis-vs-peritoneal-dialysis-on-diastolic-left-ventricular-function-dialysis-methods-and-diastolic-function
#17
Fedoua Ellouali, Fatimazahra Berkchi, Rabia Bayahia, Loubna Benamar, Mohammed Cherti
INTRODUCTION: In patients undergoing chronic dialysis, several factors appear to influence the occurrence of cardiac abnormalities. The aim of our study was to evaluate the effects of two different methods of renal replacement therapy (chronic haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD)) on left ventricular (LV) diastolic function. PATIENTS AND METHODS: We enrolled 63 patients: 21 patients on CAPD, and 42 age- and gender-matched patients on HD; 35 patients were men (55...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27583041/initial-experience-with-renal-denervation-for-the-treatment-of-resistant-hypertension-the-utility-of-novel-anesthetics-and-metaiodobenzylguanidine-scintigraphy-mibg
#18
Antonios Ziakas, Dimitrios Petroglou, Efstratios Moralidis, Konstantinos Tsioufis, Mihalis Doumas, Elena Argiriadou, Christos Savopoulos, Stavros Hadjimiltiades, Ioannis Stiliadis, Antonios Kouparanis, Sotirios Katranas, Leonidas Lillis, Athanasios Koutsakis, Haralambos Karvounis
BACKGROUND: The Symplicity-HTN 3 trial failed to show significant difference in blood pressure (BP) lowering between patients undergoing catheter-based renal denervation (RDN) and the sham-procedure arm of the study. However, there is still optimism about the role of RDN in the treatment of resistant hypertension, because identification of patients with increased sympathetic activity thus being good RDN responders, improvements in the RDN procedure and new technology RDN catheters are all expected to lead to better RDN results...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27583040/impaired-myocardial-bioenergetics-in-hfpef-and-the-role-of-antioxidants
#19
John B Hiebert, Qiuhua Shen, Amanda Thimmesch, Janet Pierce
Heart failure with preserved ejection fraction (HFpEF) is a significant cardiovascular condition for more than 50% of patients with heart failure. Currently, there is no effective treatment to decrease morbidity and mortality rates associated with HFpEF because of its pathophysiological heterogeneity. Recent evidence shows that deficiency in myocardial bioenergetics is one of the key pathophysiological factors contributing to diastolic dysfunction in HFpEF. Another known mechanism for HFpEF is an overproduction of free radicals, specifically reactive oxygen species...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27583039/the-effects-of-levosimendan-and-sodium-nitroprusside-combination-on-left-ventricular-functions-after-surgical-ventricular-reconstruction-in-coronary-artery-bypass-grafting-patients
#20
Zeki Temizturk, Davut Azboy, Atakan Atalay, Hakan Atalay, Omer Faruk Dogan
OBJECTIVE: The aim of our study was to research the effects of levosimendan (LS) and sodium nitroprusside (SNP) combination on systolic and diastolic ventricular function after coronary artery bypass grafting (CABG) who required endoventricular patch repair (EVPR). PATIENTS AND METHODS: We studied 70 patients with ischemic dilated cardiomyopathy. LS and SNP combination was administered in 35 patients (study group, SG). In the remaining patients, normal saline solution was given (placebo group, PG)...
2016: Open Cardiovascular Medicine Journal
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