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Open Neurology Journal

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https://www.readbyqxmd.com/read/27857815/the-role-of-the-iron-stain-in-assessing-intracranial-hemorrhage
#1
Rudy J Castellani, Gruschenka Mojica, George Perry
The timing of the breakdown of red blood cells and organization of hemorrhage has significance in the catabolism of heme and the processing of iron, but also has a practical application in terms of assigning, or attempting to assign, a time course with respect to traumatic events (e.g. contusions and hemorrhages). Attempts to date contusions, however, have generally been unsuccessful by macroscopic observation, whereas the microscopic observations provide broad data but are also anatomically imprecise as a function of time...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27843504/relationship-between-patients-with-clinical-auditory-neuropathy-spectrum-disorder-and-mutations-in-gjb2-gene
#2
Guilherme M de Carvalho, Priscila Z Ramos, Arthur M Castilho, Alexandre C Guimarães, Edi L Sartorato
: The auditory neuropathy is a condition which there is a dyssynchrony in the nerve conduction of the auditory nerve fibers. There is no evidence about the relationship between patients with clinical auditory neuropathy spectrum disorder and mutations in GJB2 gene. There are only two studies about this topic in the medical literature. Connexin 26 (GJB2 gene) mutations are common causes of genetic deafness in many populations and we also being reported in subjects with auditory neuropathy...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27843503/review-cav2-3-r-type-voltage-gated-ca-2-channels-functional-implications-in-convulsive-and-non-convulsive-seizure-activity
#3
Carola Wormuth, Andreas Lundt, Christina Henseler, Ralf Müller, Karl Broich, Anna Papazoglou, Marco Weiergräber
BACKGROUND: Researchers have gained substantial insight into mechanisms of synaptic transmission, hyperexcitability, excitotoxicity and neurodegeneration within the last decades. Voltage-gated Ca(2+) channels are of central relevance in these processes. In particular, they are key elements in the etiopathogenesis of numerous seizure types and epilepsies. Earlier studies predominantly targeted on Cav2.1 P/Q-type and Cav3.2 T-type Ca(2+) channels relevant for absence epileptogenesis. Recent findings bring other channels entities more into focus such as the Cav2...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27843502/molecular-mapping-alzheimer-s-disease-maldi-imaging-of-formalin-fixed-paraffin-embedded-human-hippocampal-tissue
#4
Andrea R Kelley, George Perry, Chloe Bethea, Rudolph J Castellani, Stephan B H Bach
A method for the molecular mapping of formalin-fixed, paraffin-embedded human hippocampal tissue affected by Alzheimer's disease (AD) is presented. This approach utilizes imaging mass spectrometry (IMS) with matrix-assisted laser desorption/ionization (MALDI). The usefulness of this technique in comparing diseased versus nor mal tissue at the molecular level while continuing to maintain topological and morphological integrity is evident in the preliminary findings. The critical correlation of the deparaffination, washing, matrix deposition, and analysis steps in handling the tissue sections and how these steps impact the successful mapping of human hippocampal tissue is clearly demonstrated...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27651846/oxidative-stress-induces-senescence-in-cultured-rpe-cells
#5
Nona Aryan, Brandi S Betts-Obregon, George Perry, Andrew T Tsin
The aim of this research is to determine whether oxidative stress induces cellular senescence in human retinal pigment epithelial cells. Cultured ARPE19 cells were subjected to different concentrations of hydrogen peroxide to induce oxidative stress. Cells were seeded into 24-well plates with hydrogen peroxide added to cell medium and incubated at 37°C + 5% CO2 for a 90-minute period [at 0, 300, 400 and 800 micromolar (MCM) hydrogen peroxide]. The number of viable ARPE19 cells were recorded using the Trypan Blue Dye Exclusion Method and cell senescence was measured by positive staining for senescence-associated beta-galactosidase (SA-beta-Gal) protein...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27651845/polio-patients-in-northern-italy-a-50-year-follow-up
#6
L Bertolasi, A Danese, S Monaco, M Turri, K Borg, L Werhagen
BACKGROUND: Poliomyelitis was before the immunization an important medical problem. Nowadays polio prior patients (PP) suffer from polio sequelae or have developed post-polio-syndrome (PPS) with increasing paresis, pain and fatigue. OBJECTIVES: To analyze the medical situation 50 years after acute polio. The degree of paresis was compared between the recovery 1952-1961 and 2012.The prevalence of patients fulfilling the criteria for PPS was estimated. METHOD: The study was performed in Italy...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27651844/are-temporal-differences-in-gdnf-and-nos-isoform-induction-contributors-to-neurodegeneration-a-fluorescence-microscopy-based-study
#7
Marie-Francoise Doursout, Yangyan Liang, Mya C Schiess, Angelica Padilla, Brian J Poindexter, Diane L M Hickson-Bick, Roger J Bick
BACKGROUND: Specific factors in Parkinson's disease have become targets as to their protective and degenerative effects. We have demonstrated that cytokines and PD-CSF detrimentally affect microglia and astrocyte growth. While glial cell-derived neurotrophic factor (GDNF) has been recognized as a possible neuron-rescue agent, nitric oxide synthase (NOS) has been implicated in neurodegenerative processes. OBJECTIVE: To demonstrate that glial cell activation, cytokine production, and NOS induction, play an intimate role in the loss of dopaminergic signaling, via mechanisms that are a result of inflammation and inflammatory stimuli...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27651843/osteopathic-manual-treatment-for-amyotrophic-lateral-sclerosis-a-feasibility-pilot-study
#8
Alberto Maggiani, Lucio Tremolizzo, Andrea Della Valentina, Laurent Mapelli, Silvia Sosio, Valeria Milano, Manuel Bianchi, Francesco Badi, Carolina Lavazza, Marco Grandini, Giovanni Corna, Paola Prometti, Christian Lunetta, Nilo Riva, Alessandra Ferri, Francesca Lanfranconi
BACKGROUND: Current interventions in amyotrophic lateral sclerosis (ALS) are focused on supporting quality of life (QoL) and easing pain with a multidisciplinary approach. OBJECTIVE: Primary aim of this pilot work assessed feasibility, safety, tolerability and satisfaction of osteopathic manual treatment (OMT) in 14 ALS outpatients. METHODS: Patients were randomized according to an initial single-blind design (12 weeks, T0-T1), in order to receive OMT (weekly for 4 weeks, and fortnightly for the following 8 weeks) versus usual-care (n=7 each group), followed by an OMT open period (T1-T2, once a week for 8 weeks, n=10)...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27583043/no-association-between-rs7077361-in-itga8-and-parkinson-s-disease-in-sweden
#9
Caroline Ran, Rawand Naiel Mehdi, Camilla Fardell, Fengqing Xiang, Hans Nissbrandt, Olof Sydow, Karin Wirdefeldt, Andrea Carmine Belin
BACKGROUND: Integrin alpha 8 (ITGA8) encodes the alpha 8 subunit of the integrin alpha8beta1 protein and has recently been suggested as a new candidate gene for Parkinson's disease, an age related neurodegenerative disease with unknown etiology. ITGA8 is a transmembrane protein involved in several cellular processes, such as cell adhesion, migration and cytoskeletal rearrangement. OBJECTIVE: Screen a Swedish case control material for rs7077361, a genetic variant in ITGA8, in order to investigate its possible implication in Parkinson's disease in Sweden...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27563362/potential-role-of-caffeine-in-the-treatment-of-parkinson-s-disease
#10
Mohsin H K Roshan, Amos Tambo, Nikolai P Pace
Parkinson's disease [PD] is the second most common neurodegenerative disorder after Alzheimer's disease, affecting 1% of the population over the age of 55. The underlying neuropathology seen in PD is characterised by progressive loss of dopaminergic neurons in the substantia nigra pars compacta with the presence of Lewy bodies. The Lewy bodies are composed of aggregates of α-synuclein. The motor manifestations of PD include a resting tremor, bradykinesia, and muscle rigidity. Currently there is no cure for PD and motor symptoms are treated with a number of drugs including levodopa [L-dopa]...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27563361/nutritional-alterations-associated-with-neurological-and-neurosurgical-diseases
#11
Yannis Dionyssiotis, Aris Papachristos, Konstantina Petropoulou, Jannis Papathanasiou, Panayiotis Papagelopoulos
Neurological and neurosurgical diseases lead to complications producing malnutrition increasing pathology and mortality. In order to avoid complications because of malnutrition or overcome deficiencies in nutrients supplements are often used for these subjects. The physiopathological mechanisms of malnutrition, methods of nutritional assessment and the supplemental support are reviewed in this paper based on the assumption that patients need to receive adequate nutrition to promote optimal recovery, placing nutrition as a first line treatment and not an afterthought in the rehabilitation...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27499819/child-abuse-syndrome-cas-a-newly-recognized-distinct-entity
#12
Enrico Parano, Xena Giada Pappalardo, Piero Pavone, Martino Ruggieri, Sebastiano Cavallaro
No abstract text is available yet for this article.
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27330575/nationwide-incidence-of-normal-pressure-hydrocephalus-nph-assessed-by-insurance-claim-data-in-germany
#13
Johannes Lemcke, Dirk Stengel, Florian Stockhammer, Claas Güthoff, Veit Rohde, Ullrich Meier
BACKGROUND: The purpose of this study is to investigate the epidemiology of the idiopathic normal pressure hydrocephalus (iNPH) in Germany. METHODS: The database of the nationwide Barmer Health Insurance was queried for specific combinations of corresponding International Classification of Diseases, Ninth Revision (ICD-9) codes and OPS codes (German modification of the ICPM and official classification of surgical procedures) in order to assess the number of patients treated for iNPH and the number surgical procedures associated with the disease in a 10 years period between 2003 and 2012...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27330574/cutaneous-and-mixed-nerve-silent-period-recordings-in-symptomatic-paroxysmal-kinesigenic-dyskinesia
#14
Julien Cogez, Olivier Etard, Nathalie Derache, Gilles Defer
OBJECTIVE: The underlying neurophysiologic mechanism responsible for secondary paroxysmal kinesigenic dyskinesia (PKD) is still unclear. Here, we study the pathogenesis of PKD in two patients with a demyelinating lesion in the spinal cord. METHODS: Electromyogram recordings from affected arms of two patients with spinal cord lesions presenting PKD were compared with our laboratory standards. The cutaneous silent period (CuSP), mixed nerve silent period (MnSP) and coincidence period (CiP), defined as the common period between the CuSP and MnSP, were recorded...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27053967/postural-control-of-healthy-elderly-individuals-compared-to-elderly-individuals-with-stroke-sequelae
#15
Fábio Marcon Alfieri, Marcelo Riberto, José Augusto Fernandes Lopes, Thais Raquel Filippo, Marta Imamura, Linamara Rizzo Battistella
A stroke and aging process can modify the postural control. We aimed to compare the postural control of health elderly individuals to that of individuals with stroke sequelae. This cross-sectional transversal study was made with individuals capable of walking without any assistance and that were considered clinically stable. The study had 18 individuals in the group with stroke sequelae (SG) and 34 in the healthy elderly control group (CG). The participants were evaluated for the timed up and go test (TUG) and force platform...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/26535069/the-impact-of-deep-brain-stimulation-on-sleep-and-olfactory-function-in-parkinson-s-disease
#16
David P Breen, Hu Liang Low, Anjum Misbahuddin
OBJECTIVE: Relatively little is known about the effects of deep brain stimulation on non-motor symptoms. The aim of this pilot study was to assess the impact of deep brain stimulation on sleep and olfactory function in Parkinson's disease. METHODS: Subjective sleep quality and olfactory testing were performed on 11 consecutive Parkinson's disease patients (eight men and three women) undergoing bilateral subthalamic nucleus stimulation. All patients consented to undergo clinical assessments prior to the procedure, and at regular intervals afterwards...
2015: Open Neurology Journal
https://www.readbyqxmd.com/read/26535068/onset-latency-of-motor-evoked-potentials-in-motor-cortical-mapping-with-neuronavigated-transcranial-magnetic-stimulation
#17
Elisa Kallioniemi, Minna Pitkänen, Laura Säisänen, Petro Julkunen
Cortical motor mapping in pre-surgical applications can be performed using motor evoked potential (MEP) amplitudes evoked with neuronavigated transcranial magnetic stimulation. The MEP latency, which is a more stable parameter than the MEP amplitude, has not so far been utilized in motor mapping. The latency, however, may provide information about the stress in damaged motor pathways, e.g. compression by tumors, which cannot be observed from the MEP amplitudes. Thus, inclusion of this parameter could add valuable information to the presently used technique of MEP amplitude mapping...
2015: Open Neurology Journal
https://www.readbyqxmd.com/read/26191094/validation-study-of-the-mini-mental-state-examination-in-urdu-language-for-pakistani-population
#18
Safia Awan, Naila Shahbaz, Syed Wasim Akhtar, Arsalan Ahmad, Sadaf Iqbal, Sellal Ahmed, Haider Naqvi, Mohammad Wasay
UNLABELLED: Validation study of the Mini-Mental State Examination in Urdu language for Pakistani population. OBJECTIVE: This study was conducted primarily to validate and determine the optimal cutoff score in the diagnosis of dementia among Pakistani's and study the effects of gender and education on the MMSE performance in our population. METHODS: Four hundred participants took part in the study. Patient with dementia recruited from five major hospitals from Pakistan...
2015: Open Neurology Journal
https://www.readbyqxmd.com/read/26191093/cerebral-palsy-a-lifelong-challenge-asks-for-early-intervention
#19
Christos P Panteliadis, Christian Hagel, Dieter Karch, Karl Heinemann
One of the oldest and probably well-known examples of cerebral palsy is the mummy of the Pharaoh Siptah about 1196-1190 B.C., and a letter from Hippocrates (460-390 B.C.). Cerebral palsy (CP) is one of the most common congenital or acquired neurological impairments in paediatric patients, and refers to a group of children with motor disability and related functional defects. The visible core of CP is characterized by abnormal coordination of movements and/or muscle tone which manifest very early in the development...
2015: Open Neurology Journal
https://www.readbyqxmd.com/read/26191092/solving-the-measurement-problem-and-then-steppin-out-over-the-line-riding-the-rarest-italian-crossing-the-streams-to-retrieve-stable-bioactivity-in-majorana-bound-states-of-dialy-zed-human-platelet-lysates
#20
Mark Roedersheimer
Exhaustive dialysis (ED) of lysed human platelets against dilute HCl yields stable angiogenic activity. Dialysis against a constrained external volume, with subsequent relaxation of the separation upon opening the dialysis bag, produces material able to maintain phenotypes and viability of human cells in culture better than ED material. Significant graded changes in MTT viability measurement tracked with external volume. The presence of elements smaller than the MW cutoff, capable of setting up cycling currents initiated by oriented flow of HCl across the membrane, suggests that maturation of bioactivity occurred through establishment of a novel type of geometric phase...
2015: Open Neurology Journal
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