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Open Neurology Journal

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https://www.readbyqxmd.com/read/28567135/specific-effects-of-anti-hypertensive-treatment-in-an-older-patient-with-dementia
#1
Jadwiga Attier Zmudka, Jean Marie Sérot, Salif Dao, Claire Sorel, Anne-Sophie Macaret, Olivier Balédent
Dementia is one of the most common health problems in the world. Alzheimer's disease (AD) is the most common form of dementia. The presence of vascular risk factors such as hypertension (HT) may increase the risk of AD [1,2]. The relation between blood pressure (BP) and dementia has been the subject of numerous epidemiological studies, midlife HT is a risk factor for dementia and AD [3-7] but the association between HT and risk of dementia is lower in the older population [8]. A fair modulation of an antihypertensive treatment, based on the cognitive status of the elderly, can avoid multiple complications...
2017: Open Neurology Journal
https://www.readbyqxmd.com/read/28567134/-doctor-i-hear-music-a-brief-review-about-musical-hallucinations
#2
REVIEW
Purificacion Alvarez Perez, Maria Jose Garcia-Antelo, Eduardo Rubio-Nazabal
Auditory hallucinations are defined as the abnormal perception of sound in the absence of an external auditory stimulus. Musical hallucinations constitute a complex type of auditory hallucination characterized by perception of melodies, music, or songs. Musical hallucinations are infrequent and have been described in 0.16% of a general hospital population. The auditory hallucinations are popularly associated with psychiatric disorders or degenerative neurological diseases but there may be other causes in which the patient evolves favorably with treatment...
2017: Open Neurology Journal
https://www.readbyqxmd.com/read/28567133/case-series-using-montelukast-in-patients-with-memory-loss-and-dementia
#3
Spencer I Rozin
Cognitive decline and dementia are a growing problem as the population ages. Effective therapies to prevent and treat these problems are limited. Neuro-inflammation has been suggested as a cause of dementia [1]. Montelukast is a leukotriene receptor antagonist used to treat seasonal allergies and asthma. It acts as a cysteinyl leukotriene (CysLT1) receptor antagonist blocking the action of leukotrienes and decreasing inflammation [2]. Animal studies have shown that administering Montelukast improves memory function [3]...
2017: Open Neurology Journal
https://www.readbyqxmd.com/read/28217183/affection-of-the-respiratory-muscles-in-combined-complex-i-and-iv-deficiency
#4
Josef Finsterer, Helmut Rauschka, Liane Segal, Gabor G Kovacs, Boris Rolinski
OBJECTIVES: Combined complex I+IV deficiency has rarely been reported to manifest with the involvement of the respiratory muscles. CASE REPORT: A 45y male was admitted for hypercapnia due to muscular respiratory insufficiency. He required intubation and mechanical ventilation. He had a previous history of ophthalmoparesis since age 6y, ptosis since age 23y, and anterocollis since at least age 40y. Muscle biopsy from the right deltoid muscle at age 41y was indicative of mitochondrial myopathy...
2017: Open Neurology Journal
https://www.readbyqxmd.com/read/28217182/beta-blockade-and-clinical-outcomes-in-aneurysmal-subarachnoid-hemorrhage
#5
Melody M Chang, Ronak N Raval, Jessie J Southerland, Dare A Adewumi, Khaled A Bahjri, Rajeev K Samuel, Rafeek O Woods, Olaide O Ajayi, Bryan S Lee, Frank P K Hsu, Richard L Applegate Ii, Ihab R Dorotta
BACKGROUND: Aneurysmal subarachnoid hemorrhages are frequently complicated by hypertension and neurogenic myocardial stunning. Beta blockers may be used for management of these complications. We sought to investigate sympathetic nervous system modulation by beta blockers and their effect on radiographic vasospasm, delayed cerebral infarction, discharge destination and death. METHODS: Retrospective chart review of 218 adults admitted to the ICU between 8/2004 and 9/2010 was performed...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/28217181/an-emerging-natural-history-in-the-development-mechanisms-and-worldwide-prevalence-of-major-mental-disorders
#6
Nicholas Pediaditakis
Conciliating recent findings from molecular genetics, evolutionary biology, and clinical observations together point to new understandings regarding the mechanism, development and the persistent worldwide prevalence of major mental disorders (MMDs), which should be considered the result of an evolutionary downside trade off. Temperamental/trait variability, by facilitating choices for individual and group responses, confers robustness flexibility and resilience crucial to success of our species. Extreme temperamental variants, originating evolutionarily from the asocial aspect of human nature, also constitute the premorbid personality of the disorders...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27990183/functional-and-genomic-features-of-human-genes-mutated-in-neuropsychiatric-disorders
#7
Diego A Forero, Carlos F Prada, George Perry
BACKGROUND: In recent years, a large number of studies around the world have led to the identification of causal genes for hereditary types of common and rare neurological and psychiatric disorders. OBJECTIVE: To explore the functional and genomic features of known human genes mutated in neuropsychiatric disorders. METHODS: A systematic search was used to develop a comprehensive catalog of genes mutated in neuropsychiatric disorders (NPD)...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27857815/the-role-of-the-iron-stain-in-assessing-intracranial-hemorrhage
#8
Rudy J Castellani, Gruschenka Mojica, George Perry
The timing of the breakdown of red blood cells and organization of hemorrhage has significance in the catabolism of heme and the processing of iron, but also has a practical application in terms of assigning, or attempting to assign, a time course with respect to traumatic events (e.g. contusions and hemorrhages). Attempts to date contusions, however, have generally been unsuccessful by macroscopic observation, whereas the microscopic observations provide broad data but are also anatomically imprecise as a function of time...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27843504/relationship-between-patients-with-clinical-auditory-neuropathy-spectrum-disorder-and-mutations-in-gjb2-gene
#9
Guilherme M de Carvalho, Priscila Z Ramos, Arthur M Castilho, Alexandre C Guimarães, Edi L Sartorato
The auditory neuropathy is a condition which there is a dyssynchrony in the nerve conduction of the auditory nerve fibers. There is no evidence about the relationship between patients with clinical auditory neuropathy spectrum disorder and mutations in GJB2 gene. There are only two studies about this topic in the medical literature. Connexin 26 (GJB2 gene) mutations are common causes of genetic deafness in many populations and we also being reported in subjects with auditory neuropathy. OBJECTIVE: To analyze the pattern of clinical relationship between patients with clinical diagnosis with auditory neuropathy spectrum disorder and GJB2 gene...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27843503/review-cav2-3-r-type-voltage-gated-ca-2-channels-functional-implications-in-convulsive-and-non-convulsive-seizure-activity
#10
Carola Wormuth, Andreas Lundt, Christina Henseler, Ralf Müller, Karl Broich, Anna Papazoglou, Marco Weiergräber
BACKGROUND: Researchers have gained substantial insight into mechanisms of synaptic transmission, hyperexcitability, excitotoxicity and neurodegeneration within the last decades. Voltage-gated Ca(2+) channels are of central relevance in these processes. In particular, they are key elements in the etiopathogenesis of numerous seizure types and epilepsies. Earlier studies predominantly targeted on Cav2.1 P/Q-type and Cav3.2 T-type Ca(2+) channels relevant for absence epileptogenesis. Recent findings bring other channels entities more into focus such as the Cav2...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27843502/molecular-mapping-alzheimer-s-disease-maldi-imaging-of-formalin-fixed-paraffin-embedded-human-hippocampal-tissue
#11
Andrea R Kelley, George Perry, Chloe Bethea, Rudolph J Castellani, Stephan B H Bach
A method for the molecular mapping of formalin-fixed, paraffin-embedded human hippocampal tissue affected by Alzheimer's disease (AD) is presented. This approach utilizes imaging mass spectrometry (IMS) with matrix-assisted laser desorption/ionization (MALDI). The usefulness of this technique in comparing diseased versus nor mal tissue at the molecular level while continuing to maintain topological and morphological integrity is evident in the preliminary findings. The critical correlation of the deparaffination, washing, matrix deposition, and analysis steps in handling the tissue sections and how these steps impact the successful mapping of human hippocampal tissue is clearly demonstrated...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27651846/oxidative-stress-induces-senescence-in-cultured-rpe-cells
#12
Nona Aryan, Brandi S Betts-Obregon, George Perry, Andrew T Tsin
The aim of this research is to determine whether oxidative stress induces cellular senescence in human retinal pigment epithelial cells. Cultured ARPE19 cells were subjected to different concentrations of hydrogen peroxide to induce oxidative stress. Cells were seeded into 24-well plates with hydrogen peroxide added to cell medium and incubated at 37°C + 5% CO2 for a 90-minute period [at 0, 300, 400 and 800 micromolar (MCM) hydrogen peroxide]. The number of viable ARPE19 cells were recorded using the Trypan Blue Dye Exclusion Method and cell senescence was measured by positive staining for senescence-associated beta-galactosidase (SA-beta-Gal) protein...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27651845/polio-patients-in-northern-italy-a-50-year-follow-up
#13
L Bertolasi, A Danese, S Monaco, M Turri, K Borg, L Werhagen
BACKGROUND: Poliomyelitis was before the immunization an important medical problem. Nowadays polio prior patients (PP) suffer from polio sequelae or have developed post-polio-syndrome (PPS) with increasing paresis, pain and fatigue. OBJECTIVES: To analyze the medical situation 50 years after acute polio. The degree of paresis was compared between the recovery 1952-1961 and 2012.The prevalence of patients fulfilling the criteria for PPS was estimated. METHOD: The study was performed in Italy...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27651844/are-temporal-differences-in-gdnf-and-nos-isoform-induction-contributors-to-neurodegeneration-a-fluorescence-microscopy-based-study
#14
Marie-Francoise Doursout, Yangyan Liang, Mya C Schiess, Angelica Padilla, Brian J Poindexter, Diane L M Hickson-Bick, Roger J Bick
BACKGROUND: Specific factors in Parkinson's disease have become targets as to their protective and degenerative effects. We have demonstrated that cytokines and PD-CSF detrimentally affect microglia and astrocyte growth. While glial cell-derived neurotrophic factor (GDNF) has been recognized as a possible neuron-rescue agent, nitric oxide synthase (NOS) has been implicated in neurodegenerative processes. OBJECTIVE: To demonstrate that glial cell activation, cytokine production, and NOS induction, play an intimate role in the loss of dopaminergic signaling, via mechanisms that are a result of inflammation and inflammatory stimuli...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27651843/osteopathic-manual-treatment-for-amyotrophic-lateral-sclerosis-a-feasibility-pilot-study
#15
Alberto Maggiani, Lucio Tremolizzo, Andrea Della Valentina, Laurent Mapelli, Silvia Sosio, Valeria Milano, Manuel Bianchi, Francesco Badi, Carolina Lavazza, Marco Grandini, Giovanni Corna, Paola Prometti, Christian Lunetta, Nilo Riva, Alessandra Ferri, Francesca Lanfranconi
BACKGROUND: Current interventions in amyotrophic lateral sclerosis (ALS) are focused on supporting quality of life (QoL) and easing pain with a multidisciplinary approach. OBJECTIVE: Primary aim of this pilot work assessed feasibility, safety, tolerability and satisfaction of osteopathic manual treatment (OMT) in 14 ALS outpatients. METHODS: Patients were randomized according to an initial single-blind design (12 weeks, T0-T1), in order to receive OMT (weekly for 4 weeks, and fortnightly for the following 8 weeks) versus usual-care (n=7 each group), followed by an OMT open period (T1-T2, once a week for 8 weeks, n=10)...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27583043/no-association-between-rs7077361-in-itga8-and-parkinson-s-disease-in-sweden
#16
Caroline Ran, Rawand Naiel Mehdi, Camilla Fardell, Fengqing Xiang, Hans Nissbrandt, Olof Sydow, Karin Wirdefeldt, Andrea Carmine Belin
BACKGROUND: Integrin alpha 8 (ITGA8) encodes the alpha 8 subunit of the integrin alpha8beta1 protein and has recently been suggested as a new candidate gene for Parkinson's disease, an age related neurodegenerative disease with unknown etiology. ITGA8 is a transmembrane protein involved in several cellular processes, such as cell adhesion, migration and cytoskeletal rearrangement. OBJECTIVE: Screen a Swedish case control material for rs7077361, a genetic variant in ITGA8, in order to investigate its possible implication in Parkinson's disease in Sweden...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27563362/potential-role-of-caffeine-in-the-treatment-of-parkinson-s-disease
#17
Mohsin H K Roshan, Amos Tambo, Nikolai P Pace
Parkinson's disease [PD] is the second most common neurodegenerative disorder after Alzheimer's disease, affecting 1% of the population over the age of 55. The underlying neuropathology seen in PD is characterised by progressive loss of dopaminergic neurons in the substantia nigra pars compacta with the presence of Lewy bodies. The Lewy bodies are composed of aggregates of α-synuclein. The motor manifestations of PD include a resting tremor, bradykinesia, and muscle rigidity. Currently there is no cure for PD and motor symptoms are treated with a number of drugs including levodopa [L-dopa]...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27563361/nutritional-alterations-associated-with-neurological-and-neurosurgical-diseases
#18
Yannis Dionyssiotis, Aris Papachristos, Konstantina Petropoulou, Jannis Papathanasiou, Panayiotis Papagelopoulos
Neurological and neurosurgical diseases lead to complications producing malnutrition increasing pathology and mortality. In order to avoid complications because of malnutrition or overcome deficiencies in nutrients supplements are often used for these subjects. The physiopathological mechanisms of malnutrition, methods of nutritional assessment and the supplemental support are reviewed in this paper based on the assumption that patients need to receive adequate nutrition to promote optimal recovery, placing nutrition as a first line treatment and not an afterthought in the rehabilitation...
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27499819/child-abuse-syndrome-cas-a-newly-recognized-distinct-entity
#19
Enrico Parano, Xena Giada Pappalardo, Piero Pavone, Martino Ruggieri, Sebastiano Cavallaro
No abstract text is available yet for this article.
2016: Open Neurology Journal
https://www.readbyqxmd.com/read/27330575/nationwide-incidence-of-normal-pressure-hydrocephalus-nph-assessed-by-insurance-claim-data-in-germany
#20
Johannes Lemcke, Dirk Stengel, Florian Stockhammer, Claas Güthoff, Veit Rohde, Ullrich Meier
BACKGROUND: The purpose of this study is to investigate the epidemiology of the idiopathic normal pressure hydrocephalus (iNPH) in Germany. METHODS: The database of the nationwide Barmer Health Insurance was queried for specific combinations of corresponding International Classification of Diseases, Ninth Revision (ICD-9) codes and OPS codes (German modification of the ICPM and official classification of surgical procedures) in order to assess the number of patients treated for iNPH and the number surgical procedures associated with the disease in a 10 years period between 2003 and 2012...
2016: Open Neurology Journal
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