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Open Respiratory Medicine Journal

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https://www.readbyqxmd.com/read/30008967/characteristics-and-outcomes-of-children-with-clinical-history-of-atopic-versus-non-atopic-asthma-admitted-to-a-tertiary-pediatric-intensive-care-unit
#1
Jamie Causey, Traci Gonzales, Aravind Yadav, Syed Hashmi, Wilfredo De Jesus-Rojas, Cindy Jon, Ikram Haque, Richard Johnston, James Stark, Katrina McBeth, Giuseppe Colasurdo, Ricardo Mosquera
Background: Children admitted to the Pediatric Intensive Care Unit (PICU) with status asthmaticus have variable clinical courses, and predicting their outcomes is challenging. Identifying characteristics in these patients that may require more intense intervention is important for clinical decision-making. Objective: This study sought to determine the characteristics and outcomes, specifically length of stay and mortality, of atopic versus non-atopic asthmatics admitted to a PICU with status asthmaticus...
2018: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/29643948/central-venous-oxygen-saturation-as-a-predictor-of-a-successful-spontaneous-breathing-trial-from-mechanical-ventilation-a-prospective-nested-case-control-study
#2
Ioannis Georgakas, Afroditi K Boutou, Georgia Pitsiou, Ioannis Kioumis, Milly Bitzani, Kristina Matei, Paraskevi Argyropoulou, Ioannis Stanopoulos
Background: Weaning from mechanical ventilation is a key element in the care of critically ill patients, and Spontaneous Breathing Trial (SBT) is a crucial step in this procedure. This nested case-control study aimed to evaluate whether central oxygen saturation (ScvO2 ) values and their changes could independently predict the SBT outcome among mechanically ventilated patients. Methods: A prospective cohort of patients who were mechanically ventilated for at least 48hours and fulfilled the criteria of readiness to wean constituted the study population...
2018: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/29456774/gastric-aspiration-and-its-role-in-airway-inflammation
#3
REVIEW
E B Hunt, A Sullivan, J Galvin, J MacSharry, D M Murphy
Gastro-Oesophageal Reflux (GOR) has been associated with chronic airway diseases while the passage of foreign matter into airways and lungs through aspiration has the potential to initiate a wide spectrum of pulmonary disorders. The clinical syndrome resulting from such aspiration will depend both on the quantity and nature of the aspirate as well as the individual host response. Aspiration of gastric fluids may cause damage to airway epithelium, not only because acidity is toxic to bronchial epithelial cells but also due to the effect of digestive enzymes such as pepsin and bile salts...
2018: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/29387285/evaluation-of-breath-holding-test-in-assessment-of-peripheral-chemoreflex-sensitivity-in-patients-with-chronic-heart-failure
#4
Nikita Trembach, Igor Zabolotskikh
Background: The sensitivity of peripheral chemoreflex is a marker of the severity of heart failure and the prognosis of the outcome in these patients. The assessment of chemosensitivity in these patients remains an actual problem. Objective: The aim of the study was to explore the relationship between a Breath-Holding Test (BHT) and single-breath carbon dioxide test and to evaluate the reliability of both tests in patients with Heart Failure (HF). Method: The study was performed in 43 patients with chronic heart failure...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/29081858/prolonged-cough-in-pediatric-population-first-line-care-belgian-guidelines
#5
Sophie Leconte, Stéphanie Valentin, Estelle Dromelet, Michel De Jonghe
BACKGROUND: The clinical approach to a prolonged cough, i.e . a cough lasting more than three weeks, is challenging for general practitioners as well for primary care pediatricians. What the recommended clinical approach in primary care is, how cough duration or cough characteristics impact the diagnosis, and what the efficiency and safety of antibiotics or symptomatic treatments are remain in question for primary care physicians. OBJECTIVE: The last Belgian guidelines were published in 2006 and needed to be reviewed...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28839497/bronchodilator-response-assessment-of-the-small-airways-obstructive-pattern
#6
Plamen Bokov, Clémence Martin, Sémia Graba, Karine Gillet-Juvin, Mohamed Essalhi, Christophe Delclaux
BACKGROUND: A concomitant decrease in FEV1 and FVC with normal FEV1 /FVC ratio and TLC defines small airways obstructive pattern (SAOP) and constitutes a classic pitfall of pulmonary-function-tests interpretation. OBJECTIVE: To evaluate the prevalence of flow- (FEV1 increase≥12% and 200 mL), volume- (FVC or inspiratory capacity [IC] increase≥12% and 200 mL), flow and volume-, and non-response to bronchodilation in patients with SAOP. An additional objective was to assess whether impulse oscillometry (IOS) parameters allow the diagnosis of SAOP and its reversibility...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28839496/use-of-nasal-non-invasive-ventilation-with-a-ram-cannula-in-the-outpatient-home-setting
#7
Wilfredo De Jesus Rojas, Cheryl L Samuels, Traci R Gonzales, Katrina E McBeth, Aravind Yadav, James M Stark, Cindy Jon, Ricardo A Mosquera
BACKGROUND: Nasal non-invasive-ventilation (Nasal NIV) is a mode of ventilatory support providing positive pressure to patients via a nasal interface. The RAM Cannula is an oxygen delivery device that can be used as an alternative approach to deliver positive pressure. Together they have been successfully used to provide respiratory support in neonatal in-patient settings. OBJECTIVE: To describe the outpatient use of Nasal NIV/RAM Cannula as a feasible alternative for home respiratory support in children with chronic respiratory failure...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28839495/survival-of-hypercapnic-patients-with-copd-and-obesity-hypoventilation-syndrome-treated-with-high-intensity-non-invasive-ventilation-in-the-daily-routine-care
#8
Thomas Blankenburg, Christin Benthin, Stefanie Pohl, Anett Bramer, Frank Kalbitz, Christine Lautenschläger, Wolfgang Schütte
BACKGROUND: Home ventilation is an effective treatment option for obesity hypoventilation syndrome (OHS). This therapy is still controversial for stable chronic obstructive pulmonary disease (COPD). A recent study showed reduced mortality for COPD patients receiving home ventilation with high inflation pressures and back-up respiratory rates [so called High Intensity non-invasive ventilation (NIV)]. OBJECTIVE: The purpose of this study is whether High Intensity NIV applied in the routine care of COPD and OHS patients can lead to CO2 reduction and survival data comparable to data from controlled studies...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28761563/the-emerging-role-of-the-eosinophil-and-its-measurement-in-chronic-cough
#9
REVIEW
Mahboobeh H Sadeghi, Alyn H Morice
Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastro-oesophageal reflux disease (GORD), and upper airways disease, the inflammatory mechanisms underlying these conditions differ. Recent studies on asthma have increasingly focused on its molecular phenotypes instead of clinical characteristics. Here, we proposed the hypothesis that divides cough into two groups; the eosinophilic and neutrophilic. This division will enhance our ability to recognise the type of airway inflammation which, as a consequence will lead us to more targeted and personalized treatment approaches...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28659997/24-hour-hypoxia-and-pulmonary-hypertension-in-patients-with-idiopathic-pulmonary-fibrosis
#10
Marcelo P Rodrigues, Carolina M Vissoci, Samuel P Rosa, Sandra B C Negreiros
BACKGROUND: The quantification of hypoxia based on resting partial pressure of arterial oxygen (PaO2 ) may underestimate hypoxia related to activities of daily living or sleep and thus not accurately reflect pulmonary hypertension (PH). The aim of the present study was to investigate the association of resting PaO2 with percent time of SpO2 below 90% (T90) and 88% (T88) in 24 hours. We also evaluated the capacity of hypoxia measures to predict PH in patients with idiopathic pulmonary fibrosis (IPF)...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28553418/analysis-of-the-literature-on-chronic-cough-in-children
#11
REVIEW
Marcello Bergamini, Ahmad Kantar, Renato Cutrera, Italian Pediatric Cough Interest Group
Throughout childhood, various developmental phenomena influence the cough reflex. Among these are the modifications in the anatomy and functions of the respiratory tract and the central and peripheral nervous systems. Moreover, after birth, the immunological response undergoes progressive transformations with the acquisition of immune memory processes. These conditions make infections and airway abnormalities the overwhelming cause of chronic cough in children and infants. In children, chronic cough should be treated on the basis of etiology...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28217196/effect-of-ivacaftor-on-objective-and-subjective-measures-of-cough-in-patients-with-cystic-fibrosis
#12
Shoaib Faruqi, Dejene Shiferaw, Alyn H Morice
BACKGROUND AND OBJECTIVES: Cough is a major symptom in cystic fibrosis. Ivacaftor is a novel drug which targets the G551D mutation and has been demonstrated to improve lung function and weight in the long term. It also improves symptoms of extra-oesophageal reflux. We wanted to evaluate the effect of ivacaftor on cough in cystic fibrosis. METHODS: In two patients with cystic fibrosis the Hull Airway Reflux Questionnaire (HARQ) was completed and objective cough counts were measured prior to and within 4 weeks after initiation of treatment with ivacaftor...
2016: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28217195/effect-of-short-term-exposure-to-high-particulate-levels-on-cough-reflex-sensitivity-in-healthy-tourists-a-pilot-study
#13
Ryuhei Sato, Peijun Gui, Kumiko Ito, Masahiro Kohzuki, Satoru Ebihara
BACKGROUND: Previous studies have reported a relationship between particulate air pollution and respiratory symptoms or decline in lung function, but information about acute effects of short-term exposure to airborne particulate matter (PM) on cough and pulmonary function is scarce. OBJECTIVE: To investigate the effect of short-term exposure to high concentrations of PM on the cough reflex threshold, urge-to-cough, pulmonary function, and cough-related quality of life in a group of healthy non-resident volunteers visiting Beijing, China...
2016: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28144367/determinants-of-restrictive-spirometric-pattern-in-a-sub-saharan-urban-setting-a-cross-sectional-population-based-study
#14
Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Andre Pascal Kengne
BACKGROUND: Restrictive spirometric pattern is a risk factor for all-cause and cause-specific mortality. OBJECTIVE: We assessed the prevalence of restrictive pattern and investigated its determinants in a major sub-Saharan Africa city. METHODS: Participants were adults (≥ 19 years) who took part in a population-based survey in Yaounde (Cameroon) between December 2013 and April 2014. Restrictive pattern was based on a FVC below the lower limit of the normal (LLN) and a ratio forced expiratory volume in one second (FEV1)/FVC ≥ LLN (LLN-based restrictive pattern) or a FVC <80% and FEV1/FVC ≥ LLN (fixed cut-off based restrictive pattern)...
2016: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28144366/evaluation-of-pulmonary-nodules-using-the-spyglass-direct-visualization-system-combined-with-radial-endobronchial-ultrasound-a-clinical-feasibility-study
#15
Krystelle Godbout, Simon Martel, Mathieu Simon, Noël Lampron, Antoine Delage
BACKGROUND: Sampling of peripheral pulmonary nodules with radial endobronchial ultrasound (p-EBUS) increases diagnostic yield of bronchoscopy. However, diagnostic yield is influenced by numerous factors. OBJECTIVE: We evaluated the use of SpyGlass, a one millimeter diameter optic fiber, to obtain images of the distal mucosa and of pulmonary lesions detected with p-EBUS to determine if visual aspect of the distal mucosa was predictive of diagnosis. METHODS: We prospectively recruited subjects investigated for peripheral nodules...
2016: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28144365/predicted-values-for-spirometry-may-underestimate-long-standing-asthma-severity
#16
Bruno Sposato
BACKGROUND: Asthma may show an accelerated lung function decline. Asthmatics, although having FEV1 and FEV1/VC (and z-scores) higher than the lower limit of normality, may show a significant FEV1 decline when compared to previous measurements. We assessed how many asymptomatic long-standing asthmatics (LSA) with normal lung function showed a significant FEV1 decline when an older FEV1 was taken as reference point. METHODS: 46 well-controlled LSA (age: 48.8±12.1; 23 females) with normal FEV1 and FEV1/VC according to GLI2012 references (FEV1: 94...
2016: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/27843509/association-between-health-symptoms-and-particulate-matter-from-traffic-and-residential-heating-results-from-rhine-iii-in-tartu
#17
Mihkel Pindus, Hans Orru, Marek Maasikmets, Marko Kaasik, Rain Jõgi
BACKGROUND: Traffic and residential heating are the main sources of particulate matter (PM) in Northern Europe. Wood is widely used for residential heating and vehicle numbers are increasing. Besides traffic exhaust, studded tires produce road dust that is the main source of traffic-related PM10. Several studies have associated total PM mass with health symptoms; however there has been little research on the effects of PM from specific sources. OBJECTIVE: To study the health effects resulting from traffic and local heating PM...
2016: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/27583055/lung-function-monitoring-a-randomized-agreement-study
#18
Sveinung Berntsen, Solvor B Stølevik, Petter Mowinckel, Wenche Nystad, Trine Stensrud
OBJECTIVE: To determine the agreement between devices and repeatability within devices of the forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and forced expiratory flow at 50% of FVC (FEF50) values measured using the four spirometers included in the study. METHODS: 50 (24 women) participants (20-64 years of age) completed maximum forced expiratory flow manoeuvres and measurements were performed using the following devices: MasterScreen, SensorMedics, Oxycon Pro and SpiroUSB...
2016: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/27583054/patterns-of-drug-resistance-among-tuberculosis-patients-in-west-and-northwestern-iran
#19
Leyla Sahebi, Khalil Ansarin, Parviz Mohajeri, Majid Khalili, Amir Monfaredan, Safar Farajnia, Simin Khayyat Zadeh
BACKGROUND: Tuberculosis (TB) is the leading cause of morbidity and mortality among chronic infectious diseases. OBJECTIVE: The goal of this cross-sectional study (2011-2013;2013) was to examine the patterns of TB drug resistance among HIV-negative pulmonary TB patients in regions near the Iranian border. METHOD: To this end, MTB isolates were harvested from 300 HIV-negative, pulmonary smear-positive TB patients from the northwest and west Iranian border provinces...
2016: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/27499821/pilot-study-of-a-new-adjustable-thermoplastic-mandibular-advancement-device-for-the-management-of-obstructive-sleep-apnoea-hypopnoea-syndrome-a-brief-research-letter
#20
Mohammed El Ibrahimi, Mounir Laabouri
BACKGROUND: Prefabricated adjustable thermoplastic mandibular advancement devices (PAT-MADs) are a practical short-term treatment for obstructive sleep apnoea-hypopnoea syndrome (OSAHS) in patients who have failed or refused continuous positive airway pressure (CPAP) therapy. OBJECTIVE: To assess the effectiveness of a new professionally-fitted PAT-MAD in patients with OSAHS in Morocco. METHOD: Twenty-four adults with mild, moderate or severe OSAHS were fitted with the PAT-MAD (BluePro(®); BlueSom, France)...
2016: Open Respiratory Medicine Journal
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