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Open AIDS Journal

Rimke Bijker, Jun Yong Choi, Rossana Ditangco, Sasisopin Kiertiburanakul, Man Po Lee, Sarawut Siwamogsatham, Sanjay Pujari, Jeremy Ross, Chi-Yuen Wong, Wing-Wai Wong, Evy Yunihastuti, Matthew Law
Introduction: Cardiovascular diseases (CVD) are becoming more prevalent in HIV-infected populations as they age largely due to improved treatment outcomes. Assessment of CVD risk and CVD risk factors in HIV-positive populations has focused on high income settings, while there are limited studies evaluating CVD in HIV-positive populations in the Asian region. Materials and Methods: We provided an overview of the prevalence and incidence of CVD and its risk factors in adult HIV-positive populations, and of the strategies currently in place for CVD management in the Asian region...
2017: Open AIDS Journal
Vanessa Cooper, Jane Clatworthy, Jennifer Whetham, EmERGE Consortium
Background: Self-management is an important aspect of long-term HIV treatment. Mobile technologies offer the potential to efficiently deliver interventions to facilitate HIV self-management. The last comprehensive review of such mHealth interventions was conducted in 2011. Given the rapidly evolving field, a need was identified for an updated review of the literature. Objective: The study aimed to describe and evaluate current evidence-based mHealth interventions to support self-management in HIV...
2017: Open AIDS Journal
Gérard Grésenguet, Jean de Dieu Longo, Serge Tonen-Wolyec, Ralph-Sydney Mboumba Bouassa, Laurent Belec
Background: Opportunities for HIV testing could be enhanced by offering HIV self-testing (HIVST) in populations that fear stigma and discrimination when accessing conventional HIV counselling and testing. Field experience with HIVST was poorly reported in French-speaking African countries. Objective: To investigate the usability of HIVST in Bangui, Central African Republic. Methods: The prototype self-test Exacto® Test HIV (Biosynex, Strasbourg, France) was used to assess the usability of HIVST in 300 adults living in Bangui, according to WHO technical recommendations...
2017: Open AIDS Journal
Antonio Marra, Giosuè Scognamiglio, Ilaria Peluso, Gerardo Botti, Celeste Fusciello, Amelia Filippelli, Paolo A Ascierto, Stefano Pepe, Francesco Sabbatino
Introduction: Immunotherapy with immune checkpoint inhibitors increases the overall survival of patients with metastatic melanoma regardless of their oncogene addicted mutations. However, no data is available from clinical trials of effective therapies in subgroups of melanoma patients that carry chronic infective diseases such as HIV. Evidences suggest a key role of the immune checkpoint molecules as a mechanism of immune escape not only from melanoma but also from HIV host immune response...
2017: Open AIDS Journal
Madhuri Thakar, Francis Angira, Kovit Pattanapanyasat, Alan H B Wu, Maurice O'Gorman, Hui Zeng, Chenxue Qu, Bharati Mahajan, Kasama Sukapirom, Danying Chen, Yu Hao, Yan Gong, Monika De Arruda Indig, Sharon Graminske, Diana Orta, Nicole d'Empaire, Beverly Lu, Imelda Omana-Zapata, Clement Zeh
Background: The BD FACSPresto™ system uses capillary and venous blood to measure CD4 absolute counts (CD4), %CD4 in lymphocytes, and hemoglobin (Hb) in approximately 25 minutes. CD4 cell count is used with portable CD4 counters in resource-limited settings to manage HIV/AIDS patients. A method comparison was performed using capillary and venous samples from seven clinical laboratories in five countries. The BD FACSPresto system was assessed for variability between laboratory, instrument/operators, cartridge lots and within-run at four sites...
2017: Open AIDS Journal
Idongesit Godwin Utuk, Kayode Omoniyi Osungbade, Taiwo Akinyode Obembe, David Ayobami Adewole, Victoria Oluwabunmi Oladoyin
Background: Despite demonstrating global concerns about infection in the workplace, very little research has explored how co-workers react to those living with HIV in the workplace in sub-Saharan Africa. This study aimed to assess the level of stigmatising attitude towards co-workers living with HIV in the workplace. Methods: The study was a descriptive cross-sectional survey involving 403 respondents. They were recruited from selected companies through a multistage sampling technique...
2017: Open AIDS Journal
M Mosepele, V Letsatsi, L Mokgatlhe, F P Hudson, R Gross
BACKGROUND: Little is known about the use of statin for cardiovascular disease (CVD) risk reduction among HIV-infected patients on protease inhibitors (PI`s) in sub-Saharan Africa (SSA). OBJECTIVE: Cholesterol screening and statin use were retrospectively assessed among HIV-infected participants on PI`s between 2008 and 2012 at a large urban HIV clinic in Botswana. METHODS: Proportion of participants screened per year was calculated and statin indication was assessed using atherosclerosis CVD (ASCVD) and Framingham risk (FRS) scores as of the year 2012 guidelines...
2017: Open AIDS Journal
Refilwe Ramoshaba, Sello Levy Sithole
BACKGROUND: The pandemic of Human Immunodeficiency Virus (HIV) is the most severe health challenge affecting children across the world. It is estimated that more than 90% of all HIV infections in children result from Mother-to-Child Transmission (MTCT). Poor knowledge and awareness of MTCT and Prevention of Mother-to-Child Transmission (PMTCT) among HIV positive mothers and their babies is a major setback to the success of the PMTCT programmes. METHODS: A qualitative approach and a cross-sectional design were applied in this study...
2017: Open AIDS Journal
Boushab Mohamed Boushab, Malick Fall Fatim-Zahra, Ould Cheikh Melaïnine Mohamed Limame, Basco Leonardo Kishi
SUMMARY: People living with HIV/AIDS (PLWHA) are often discriminated against in their daily lives. The objective of this descriptive and transversal study was to describe the experiences of PLWHA followed at a specialized outpatient center in Nouakchott to assess the forms of stigma from the perspective of those who suffer from discrimination. METHODS: All HIV-positive patients over the age of 18 years who were aware of their HIV status and provided consent to participate in the study were included from June 1 to 29, 2015...
2017: Open AIDS Journal
Mehwish Younas, Christina Psomas, Vikram Mehraj, Renaud Cezar, Pierre Portales, Edouard Tuaillon, Adeline Guigues, Jacques Reynes, Pierre Corbeau, Jean-Pierre Routy
INTRODUCTION: Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease. OBSERVATION: Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation. RESULTS: Here we show that it is not the case in patients with suppressed viremia...
2017: Open AIDS Journal
Kudakwashe Mhandire, Tommy Mlambo, Lynn Sodai Zijenah, Kerina Duri, Kudzaishe Mateveke, Mqondisi Tshabalala, Doreen Zvipo Mhandire, Cuthbert Musarurwa, Petronella Taonga Wekare, Lovemore Ronald Mazengera, Hilda Tendisa Matarira, Babill Stray-Pedersen
BACKGROUND: Chronic immune activation is a feature of HIV infection associated with accelerated HIV disease progression. There is conflicting data on the association of biomarkers of immune activation with traditional markers of HIV disease progression; CD4 counts and viral load (VL). OBJECTIVE: The study aimed to determine the association of biomarkers of immune activation; interferon (IFN)-γ-induced protein 10 (IP-10) and soluble cluster of differentiation 14 (sCD14) in chronic HIV infection with traditional markers of HIV disease progression...
2017: Open AIDS Journal
Miyuki Kawado, Shuji Hashimoto, Shin-Ichi Oka, Katsuyuki Fukutake, Satoshi Higasa, Hiroshi Yatsuhashi, Miwa Ogane, Manabu Okamoto, Takuma Shirasaka
OBJECTIVE: This study aimed to determine improvement in HIV RNA levels and the CD4 cell count by switching to an antiretroviral regimen with an integrase strand transfer inhibitor (INSTI) in patients with HIV. METHOD: This study was conducted on Japanese patients with HIV who were infected by blood products in the 1980s. Data were collected between 2007 and 2014. Data of 564 male hemophiliac patients with HIV from the Japan Cohort Study of HIV Patients Infected through Blood Products were available...
2017: Open AIDS Journal
Teshale Ayele, Habtemu Jarso, Girma Mamo
BACKGROUND: Tenofovir (TDF) based regimen is one of the first line agents that has been utilized routinely since 2013 in Ethiopia. Unfortunately, there is limited information regarding the Clinical outcomes and associated risk factors in this setting, where patients generally present late, have high rates of TB and other infectious conditions. METHODS: A two year retrospective cohort study was conducted from February 10/2015 to March 10/2015 at Jimma University Specialized Hospital...
2017: Open AIDS Journal
Isabelle Funck-Brentano, Lambert Assoumou, Florence Veber, Despina Moshous, Pierre Frange, Stéphane Blanche
BACKGROUND: Resilience of perinatally HIV-infected youth in European countries is poorly studied. Life satisfaction and expectations for adulthood are rarely examined. OBJECTIVE: This cross-sectional, descriptive study of a French cohort of 54 perinatally HIV-infected adolescents raised in France (age 14-20 years) aimed to (1) evaluate their psychosocial adjustment, (2) identify their expectations for adulthood and (3) delineate risk and protective factors associated with mental health, life satisfaction, and HIV-1 viral load level...
2016: Open AIDS Journal
Henry Namme Luma, Servais Albert Fiacre Bagnaka Eloumou, Domin Sone Majunda Ekaney, Fernando Kemta Lekpa, Olivier Donfack-Sontsa, Bertrand Hugo Mbatchou Ngahane, Yacouba Njankouo Mapoure
BACKGROUND: Liver disease related to Hepatitis B (HBV) and C (HCV) infection has become a major cause of morbidity and mortality in HIV/AIDS patients. Data on the prevalence of HBV and HCV in Cameroon remains inconclusive. OBJECTIVE: We aimed to determine the sero-prevalence and correlates of Hepatitis markers in HIV/AIDS patients in two Regional Hospitals. METHODS: A cross-sectional study carried out from December 2014 to March 2015. HIV/AIDS patients aged 21 were included and above, receiving care at HIV treatment centres...
2016: Open AIDS Journal
C D Mossoro-Kpinde, M A Jenabian, J C Gody, L Robin, P Talla, Jdd Longo, G Grésenguet, L Belec
BACKGROUND: Several commercially available molecular techniques were developed based on subtype B of HIV-1, which represents only 10% of HIV strains worldwide. Indeed, in sub-Saharan Africa, non-B subtypes of HIV-1 are predominant. The aim of this study was to evaluate the performances of the COBAS(®) AmpliPrep/COBAS(®) (CAP/CTM) HIV-1 Qualitative assays to detect the broad range of HIV-1 variants circulating in Central Africa and compare to the outgoing CAP/CTM HIV-1 Quantitative test v2...
2016: Open AIDS Journal
Vitaris Kodogo, Danai Tavonga Zhou, Olav Oektedalen, Kerina Duri, Babill Stray-Pedersen, Exnevia Gomo
BACKGROUND: Dyslipidemia does not occur in all HIV-infected or antiretroviral therapy-experienced patients suggesting role of host genetic factors but there is paucity of data on association between dyslipidemia and gene polymorphisms in Zimbabwe. OBJECTIVE: To determine association of lipoprotein levels and apolipoprotein B polymorphisms in HIV-infected adults. METHOD: Demographic data were collected from 103 consenting patients; lipoprotein levels were determined and blood samples were successfully genotyped for both apolipoprotein B 2488C>T Xba1 and apolipoprotein B 4154G>A p...
2016: Open AIDS Journal
Marion Peyre, Aurélie Gauchet, Matthieu Roustit, Pascale Leclercq, Olivier Epaulard
BACKGROUND: Physician attitude influences the way patients cope with diagnosis and therapy in chronic severe diseases such as cancer. Previous studies showed that such an effect exists in HIV care; it is likely that it begins with the first contact with a physician. OBJECTIVE: We aimed to explore in HIV-infected persons their perception of the first consultation they had with an HIV specialist (PFC-H), and whether this perception correlates with adherence to antiretroviral therapy...
2016: Open AIDS Journal
William K Adih, Richard M Selik, H Irene Hall, Aruna Surendera Babu, Ruiguang Song
BACKGROUND: Published death rates for persons with HIV have not distinguished deaths due to HIV from deaths due to other causes. Cause-specific death rates would allow better assessment of care needs. METHODS: Using data reported to the US national HIV surveillance system, we examined a) associations between selected decedent characteristics and causes of death during 2007-2011, b) trends in rates of death due to underlying causes among persons with AIDS during 1990-2011, and among all persons with diagnosed HIV infection (with or without AIDS) during 2000-2011...
2016: Open AIDS Journal
Ronaldo Iachan, Christopher H Johnson, Richard L Harding, Tonja Kyle, Pedro Saavedra, Emma L Frazier, Linda Beer, Christine L Mattson, Jacek Skarbinski
BACKGROUND: Health surveys of the general US population are inadequate for monitoring human immunodeficiency virus (HIV) infection because the relatively low prevalence of the disease (<0.5%) leads to small subpopulation sample sizes. OBJECTIVE: To collect a nationally and locally representative probability sample of HIV-infected adults receiving medical care to monitor clinical and behavioral outcomes, supplementing the data in the National HIV Surveillance System...
2016: Open AIDS Journal
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