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Open AIDS Journal

Kaymarlin Govender, Wilfred G B Masebo, Patrick Nyamaruze, Richard G Cowden, Bettina T Schunter, Anurita Bains
No abstract text is available yet for this article.
2018: Open AIDS Journal
Kaymarlin Govender, Wilfred G B Masebo, Patrick Nyamaruze, Richard G Cowden, Bettina T Schunter, Anurita Bains
The global commitment to ending the AIDS epidemic by 2030 places HIV prevention at the centre of the response. With the disease continuing to disproportionately affect young populations in the Eastern and Southern African Region (ESAR), particularly adolescent girls and young women, reducing HIV infections in this group is integral to achieving this ambitious target. This paper examines epidemiological patterns of the HIV epidemic among adolescents and young people, indicating where HIV prevention efforts need to be focused ( i...
2018: Open AIDS Journal
Adane Teshome Kefale, Tegene Legese Dadi, Tessema Tsehay Biru, Teshale Ayele Mega
Background: Findings from different studies report inferior clinical and virologic efficacy with TDF/3TC/NVP. But, some studies show that, there was no statistically significant difference in mortality among ZDV and TDF based regimens. The objective of this review was to systematically identify, appraise and synthesize the best available evidence on efficacy and safety of TDF based regimen as compared to ZDV based regimens. Methods: A three-step search strategy was used to locate published and unpublished studies...
2018: Open AIDS Journal
Lora L Sabin, Lauren Mansfield, Mary Bachman DeSilva, Taryn Vian, Zhong Li, Xie Wubin, Allen L Gifford, Yiyao Barnoon, Christopher J Gill
Background: Few Antiretroviral Therapy (ART) adherence trials investigate the reasons for intervention success or failure among HIV-positive individuals. Objectives: To conduct qualitative research to explore the reasons for effectiveness of a 6-month mHealth (mobile health) trial that improved adherence among ART patients in China. The intervention utilized Wireless Pill Containers (WPCs) to provide, real-time SMS reminders, WPC-generated adherence reports, and report-informed counseling...
2018: Open AIDS Journal
Yee Shan Low, Farida Islahudin, Kamarul Azahar Mohd Razali, Shafnah Adnan
Background: Treatment options among Human Immunodeficiency Virus (HIV)-infected children are limited as only a few Highly Active Antiretroviral Therapy (HAART) are approved worldwide for paediatric use. Among children, frequent changes in HAART regimen can rapidly exhaust treatment options, and information addressing this issue is scarce. Objective: The aim of the study was to determine factors associated with the modification of initial HAART regimen modification among HIV-infected children...
2018: Open AIDS Journal
Mariantonietta Di Stefano, Giovanna D'Andrea, Fabio Zoboli, Giuseppina Faleo, Massimo Fasano, Domenico Martinelli, Maurizio Margaglione, Teresa A Santantonio, Josè R Fiore
Background: HIV infection is a known prothrombotic condition but factors involved are still controversial. A role for antiretrovirals, especially protease inhibitors, was advocated. Objectives: The study aimed to analyze the levels of anticoagulant proteins in virally suppressed HIV-infected subjects treated with different anti-retroviral regimens. Materials and Methods: Forty-four patients were included in the study. C and PS, D-Dimers and Fibrinogen levels were determined as well as APC-resistance...
2018: Open AIDS Journal
Janice Du Mont, Lily Van, Daisy Kosa, Sheila Macdonald
Among 136 women sexually assaulted by a current or former male intimate partner presenting to hospital-based violence treatment centers, 58 (42.6%) received HIV post-exposure prophylaxis (HIV PEP) counseling by a specially trained sexual assault nurse. We identified factors that were associated with receipt of HIV PEP counseling. Those who received counseling were more likely to have been younger than 25 years of age, single, a student, vaginally penetrated, and have received various other services ( e.g ., STI prophylaxis)...
2018: Open AIDS Journal
Rimke Bijker, Jun Yong Choi, Rossana Ditangco, Sasisopin Kiertiburanakul, Man Po Lee, Sarawut Siwamogsatham, Sanjay Pujari, Jeremy Ross, Chi-Yuen Wong, Wing-Wai Wong, Evy Yunihastuti, Matthew Law
Introduction: Cardiovascular diseases (CVD) are becoming more prevalent in HIV-infected populations as they age largely due to improved treatment outcomes. Assessment of CVD risk and CVD risk factors in HIV-positive populations has focused on high income settings, while there are limited studies evaluating CVD in HIV-positive populations in the Asian region. Materials and Methods: We provided an overview of the prevalence and incidence of CVD and its risk factors in adult HIV-positive populations, and of the strategies currently in place for CVD management in the Asian region...
2017: Open AIDS Journal
Vanessa Cooper, Jane Clatworthy, Jennifer Whetham, EmERGE Consortium
Background: Self-management is an important aspect of long-term HIV treatment. Mobile technologies offer the potential to efficiently deliver interventions to facilitate HIV self-management. The last comprehensive review of such mHealth interventions was conducted in 2011. Given the rapidly evolving field, a need was identified for an updated review of the literature. Objective: The study aimed to describe and evaluate current evidence-based mHealth interventions to support self-management in HIV...
2017: Open AIDS Journal
Gérard Grésenguet, Jean de Dieu Longo, Serge Tonen-Wolyec, Ralph-Sydney Mboumba Bouassa, Laurent Belec
Background: Opportunities for HIV testing could be enhanced by offering HIV self-testing (HIVST) in populations that fear stigma and discrimination when accessing conventional HIV counselling and testing. Field experience with HIVST was poorly reported in French-speaking African countries. Objective: To investigate the usability of HIVST in Bangui, Central African Republic. Methods: The prototype self-test Exacto® Test HIV (Biosynex, Strasbourg, France) was used to assess the usability of HIVST in 300 adults living in Bangui, according to WHO technical recommendations...
2017: Open AIDS Journal
Antonio Marra, Giosuè Scognamiglio, Ilaria Peluso, Gerardo Botti, Celeste Fusciello, Amelia Filippelli, Paolo A Ascierto, Stefano Pepe, Francesco Sabbatino
Introduction: Immunotherapy with immune checkpoint inhibitors increases the overall survival of patients with metastatic melanoma regardless of their oncogene addicted mutations. However, no data is available from clinical trials of effective therapies in subgroups of melanoma patients that carry chronic infective diseases such as HIV. Evidences suggest a key role of the immune checkpoint molecules as a mechanism of immune escape not only from melanoma but also from HIV host immune response...
2017: Open AIDS Journal
Madhuri Thakar, Francis Angira, Kovit Pattanapanyasat, Alan H B Wu, Maurice O'Gorman, Hui Zeng, Chenxue Qu, Bharati Mahajan, Kasama Sukapirom, Danying Chen, Yu Hao, Yan Gong, Monika De Arruda Indig, Sharon Graminske, Diana Orta, Nicole d'Empaire, Beverly Lu, Imelda Omana-Zapata, Clement Zeh
Background: The BD FACSPresto™ system uses capillary and venous blood to measure CD4 absolute counts (CD4), %CD4 in lymphocytes, and hemoglobin (Hb) in approximately 25 minutes. CD4 cell count is used with portable CD4 counters in resource-limited settings to manage HIV/AIDS patients. A method comparison was performed using capillary and venous samples from seven clinical laboratories in five countries. The BD FACSPresto system was assessed for variability between laboratory, instrument/operators, cartridge lots and within-run at four sites...
2017: Open AIDS Journal
Idongesit Godwin Utuk, Kayode Omoniyi Osungbade, Taiwo Akinyode Obembe, David Ayobami Adewole, Victoria Oluwabunmi Oladoyin
Background: Despite demonstrating global concerns about infection in the workplace, very little research has explored how co-workers react to those living with HIV in the workplace in sub-Saharan Africa. This study aimed to assess the level of stigmatising attitude towards co-workers living with HIV in the workplace. Methods: The study was a descriptive cross-sectional survey involving 403 respondents. They were recruited from selected companies through a multistage sampling technique...
2017: Open AIDS Journal
M Mosepele, V Letsatsi, L Mokgatlhe, F P Hudson, R Gross
BACKGROUND: Little is known about the use of statin for cardiovascular disease (CVD) risk reduction among HIV-infected patients on protease inhibitors (PI`s) in sub-Saharan Africa (SSA). OBJECTIVE: Cholesterol screening and statin use were retrospectively assessed among HIV-infected participants on PI`s between 2008 and 2012 at a large urban HIV clinic in Botswana. METHODS: Proportion of participants screened per year was calculated and statin indication was assessed using atherosclerosis CVD (ASCVD) and Framingham risk (FRS) scores as of the year 2012 guidelines...
2017: Open AIDS Journal
Refilwe Ramoshaba, Sello Levy Sithole
BACKGROUND: The pandemic of Human Immunodeficiency Virus (HIV) is the most severe health challenge affecting children across the world. It is estimated that more than 90% of all HIV infections in children result from Mother-to-Child Transmission (MTCT). Poor knowledge and awareness of MTCT and Prevention of Mother-to-Child Transmission (PMTCT) among HIV positive mothers and their babies is a major setback to the success of the PMTCT programmes. METHODS: A qualitative approach and a cross-sectional design were applied in this study...
2017: Open AIDS Journal
Boushab Mohamed Boushab, Malick Fall Fatim-Zahra, Ould Cheikh Melaïnine Mohamed Limame, Basco Leonardo Kishi
SUMMARY: People living with HIV/AIDS (PLWHA) are often discriminated against in their daily lives. The objective of this descriptive and transversal study was to describe the experiences of PLWHA followed at a specialized outpatient center in Nouakchott to assess the forms of stigma from the perspective of those who suffer from discrimination. METHODS: All HIV-positive patients over the age of 18 years who were aware of their HIV status and provided consent to participate in the study were included from June 1 to 29, 2015...
2017: Open AIDS Journal
Mehwish Younas, Christina Psomas, Vikram Mehraj, Renaud Cezar, Pierre Portales, Edouard Tuaillon, Adeline Guigues, Jacques Reynes, Pierre Corbeau, Jean-Pierre Routy
INTRODUCTION: Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease. OBSERVATION: Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation. RESULTS: Here we show that it is not the case in patients with suppressed viremia...
2017: Open AIDS Journal
Kudakwashe Mhandire, Tommy Mlambo, Lynn Sodai Zijenah, Kerina Duri, Kudzaishe Mateveke, Mqondisi Tshabalala, Doreen Zvipo Mhandire, Cuthbert Musarurwa, Petronella Taonga Wekare, Lovemore Ronald Mazengera, Hilda Tendisa Matarira, Babill Stray-Pedersen
BACKGROUND: Chronic immune activation is a feature of HIV infection associated with accelerated HIV disease progression. There is conflicting data on the association of biomarkers of immune activation with traditional markers of HIV disease progression; CD4 counts and viral load (VL). OBJECTIVE: The study aimed to determine the association of biomarkers of immune activation; interferon (IFN)-γ-induced protein 10 (IP-10) and soluble cluster of differentiation 14 (sCD14) in chronic HIV infection with traditional markers of HIV disease progression...
2017: Open AIDS Journal
Miyuki Kawado, Shuji Hashimoto, Shin-Ichi Oka, Katsuyuki Fukutake, Satoshi Higasa, Hiroshi Yatsuhashi, Miwa Ogane, Manabu Okamoto, Takuma Shirasaka
OBJECTIVE: This study aimed to determine improvement in HIV RNA levels and the CD4 cell count by switching to an antiretroviral regimen with an integrase strand transfer inhibitor (INSTI) in patients with HIV. METHOD: This study was conducted on Japanese patients with HIV who were infected by blood products in the 1980s. Data were collected between 2007 and 2014. Data of 564 male hemophiliac patients with HIV from the Japan Cohort Study of HIV Patients Infected through Blood Products were available...
2017: Open AIDS Journal
Teshale Ayele, Habtemu Jarso, Girma Mamo
BACKGROUND: Tenofovir (TDF) based regimen is one of the first line agents that has been utilized routinely since 2013 in Ethiopia. Unfortunately, there is limited information regarding the Clinical outcomes and associated risk factors in this setting, where patients generally present late, have high rates of TB and other infectious conditions. METHODS: A two year retrospective cohort study was conducted from February 10/2015 to March 10/2015 at Jimma University Specialized Hospital...
2017: Open AIDS Journal
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