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Circulation. Heart Failure

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https://www.readbyqxmd.com/read/30354403/putting-the-stress-on-ufm1-ubiquitin-fold-modifier-1
#1
EDITORIAL
James D Sutherland, Rosa Barrio
No abstract text is available yet for this article.
October 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354402/rare-case-of-pericardial-angiosarcoma
#2
Yuman Li, Bin Wang, Li Zhang, Yali Yang, Jing Wang, Qing Lv, Mingxing Xie
No abstract text is available yet for this article.
October 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354401/ufm1-specific-ligase-ufl1-regulates-endoplasmic-reticulum-homeostasis-and-protects-against-heart-failure
#3
Jie Li, Guihua Yue, Wenxia Ma, Aizhen Zhang, Jianqiu Zou, Yafei Cai, Xiaoli Tang, Jun Wang, Jinbao Liu, Honglin Li, Huabo Su
BACKGROUND: Defects in protein homeostasis are sufficient to provoke cardiac remodeling and dysfunction. Although posttranslational modifications by ubiquitin and ubiquitin-like proteins are emerging as an important regulatory mechanism of protein function, the role of Ufm1 (ubiquitin-fold modifier 1)-a novel ubiquitin-like protein-has not been explored in either the normal or stressed heart. METHODS AND RESULTS: Western blotting revealed that Ufl1 (Ufm1-specific E3 ligase 1)-an enzyme essential for Ufm1 modification-was increased in hypertrophic mouse hearts but reduced in the failing hearts of patients with dilated cardiomyopathy...
October 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354400/the-american-heart-association-heart-failure-summit-bethesda-april-12-2017
#4
Pamela N Peterson, Larry A Allen, Paul A Heidenreich, Nancy M Albert, Ileana L Piña
The American Heart Association convened a meeting to summarize the changing landscape of heart failure (HF), anticipate upcoming challenges and opportunities to achieve coordinated identification and treatment, and to recommend areas in need of focused efforts. The conference involved representatives from clinical care organizations, governmental agencies, researchers, patient advocacy groups, and public and private healthcare partners, demonstrating the breadth of stakeholders interested in improving care and outcomes for patients with HF...
October 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354399/igfbp7-insulin-like-growth-factor-binding-protein-7-and-neprilysin-inhibition-in-patients-with-heart-failure
#5
James L Januzzi, Milton Packer, Brian Claggett, Jiankang Liu, Amil M Shah, Michael R Zile, Burkert Pieske, Adriaan Voors, Parul U Gandhi, Margaret F Prescott, Victor Shi, Martin P Lefkowitz, John J V McMurray, Scott D Solomon
BACKGROUND: Increased activity of IGFBP7 (insulin-like growth factor-binding protein-7) is associated with cellular senescence, tissue aging, and obesity. IGFBP7 may be related to heart failure with preserved ejection fraction, a disease of elderly obese people. METHODS AND RESULTS: In a subset of patients with heart failure with preserved ejection fraction (N=228) randomized to receive sacubitril/valsartan versus valsartan, IGFBP7 concentrations were measured at baseline, 12 weeks, and 36 weeks...
October 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354398/use-of-oral-anticoagulation-in-eligible-patients-discharged-with-heart-failure-and-atrial-fibrillation
#6
Nancy Luo, Haolin Xu, Hani Jneid, Gregg C Fonarow, Renato D Lopes, Jonathan P Piccini, Anne B Curtis, Andrea M Russo, William R Lewis, Roland A Matsouaka, Christopher B Granger, Robert J Mentz, Sana M Al-Khatib
BACKGROUND: Stroke prophylaxis in patients with atrial fibrillation (AF) and heart failure (HF) in the era of direct oral anticoagulants is not well characterized. Using data from American Heart Association Get With The Guidelines-AFIB, we sought to evaluate oral anticoagulation (OAC) use at discharge among AF patients with concomitant HF. METHODS AND RESULTS: AF patients with a diagnosis of HF hospitalized from January 2013 to March 2017 were included. We compared patient characteristics and use of OAC at discharge among patients with reduced (redundant ejection fraction [EF], EF≤40%), borderline (40%<EF<50%), and preserved (EF≥50%) EF using multivariable mixed logistic regression models...
October 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354397/omega-3-therapy-is-associated-with-reduced-gastrointestinal-bleeding-in-patients-with-continuous-flow-left-ventricular-assist-device
#7
Teruhiko Imamura, Ann Nguyen, Daniel Rodgers, Gene Kim, Jayant Raikhelkar, Nitasha Sarswat, Sara Kalantari, Bryan Smith, Ben Chung, Nikhil Narang, Colleen Juricek, Daniel Burkhoff, Tae Song, Takeyoshi Ota, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel
Background Gastrointestinal bleeding (GIB) is a common complication seen in patients supported with left ventricular assist devices (LVADs) and is related to increased inflammation and angiogenesis. Omega-3 is an unsaturated fatty acid that possesses anti-inflammatory and antiangiogenic properties. This study aims to assess the prophylactic efficacy of treatment with omega-3 on the incidence of GIB in LVAD patients. Methods and Results Among consecutive 166 LVAD patients enrolled in this analysis, 30 patients (49 years old and 26 male) received 4 mg/d of omega-3 therapy for 310±87 days and 136 patients in the control group (58 years old and 98 male) were observed for 302±102 days...
October 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354396/the-promise-of-induced-pluripotent-stem-cell-derived-cardiomyocytes-to-treat-heart-failure
#8
Jordan J Lancaster, Jen Watson Koevary, Ikeotunye Royal Chinyere, Steven Goldman
No abstract text is available yet for this article.
October 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354369/bleeding-and-angiogenesis-during-continuous-flow-left-ventricular-assist-device-support
#9
EDITORIAL
Omar Saeed, Snehal R Patel, Ulrich P Jorde
No abstract text is available yet for this article.
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354368/left-atrial-contracture-or-failure-to-dilate
#10
Masaru Obokata, Yogesh N V Reddy, Jeong Hoon Yang, Brandon M Wiley, Barry A Borlaug
No abstract text is available yet for this article.
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354367/validity-of-performance-and-outcome-measures-for-heart-failure
#11
Jay Patel, Alex Sandhu, Justin Parizo, Yasbanoo Moayedi, Gregg C Fonarow, Paul A Heidenreich
Background Numerous quality metrics for heart failure (HF) care now exist based on process and outcome. What remains unclear, however, is if the correct quality metrics are being emphasized. To determine the validity of certain measures, we compared correlations between measures and reliability over time. Measures assessed include guideline-recommended β-blocker (BB), any BB, angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker, mineralocorticoid receptor antagonist, and hydralazine/isosorbide dinitrate (in blacks) use among candidates, 30-day mortality, 1-year mortality, and 30-day readmission...
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354366/incident-atrial-fibrillation-is-associated-with-myh7-sarcomeric-gene-variation-in-hypertrophic-cardiomyopathy
#12
Seung-Pyo Lee, Euan A Ashley, Julian Homburger, Colleen Caleshu, Eric M Green, Daniel Jacoby, Steven D Colan, Edmundo Arteaga-Fernández, Sharlene M Day, Francesca Girolami, Iacopo Olivotto, Michelle Michels, Carolyn Y Ho, Marco V Perez
Background Although atrial fibrillation (AF) is common in hypertrophic cardiomyopathy (HCM) patients, the relationship between genetic variation and AF has been poorly defined. Characterizing genetic subtypes of HCM and their associations with AF may help to improve personalized medical care. We aimed to investigate the link between sarcomeric gene variation and incident AF in HCM patients. Methods and Results Patients from the multinational Sarcomeric Human Cardiomyopathy Registry were followed for incident AF...
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354365/phosphodiesterase-5-is-elevated-in-failing-single-ventricle-myocardium-and-affects-cardiomyocyte-remodeling-in-vitro
#13
Anastacia M Garcia, Stephanie J Nakano, Anis Karimpour-Fard, Karin Nunley, Penny Blain-Nelson, Natalie M Stafford, Brian L Stauffer, Carmen C Sucharov, Shelley D Miyamoto
Background Single ventricle (SV) congenital heart disease is fatal without intervention, and eventual heart failure is a major cause of morbidity and mortality. Although there are no proven medical therapies for the treatment or prevention of heart failure in the SV heart disease population, phosphodiesterase-5 inhibitors (PDE5i), such as sildenafil, are increasingly used. Although the pulmonary vasculature is the primary target of PDE5i therapy in patients with SV heart disease, the effects of PDE5i on the SV heart disease myocardium remain largely unknown...
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354364/venoarterial-extracorporeal-membrane-oxygenation-for-cardiogenic-shock-and-cardiac-arrest
#14
Prashant Rao, Zain Khalpey, Richard Smith, Daniel Burkhoff, Robb D Kociol
Venoarterial extracorporeal membrane oxygenation (VA-ECMO)-also referred to as extracorporeal life support-is a form of temporary mechanical circulatory support and simultaneous extracorporeal gas exchange. The initiation of VA-ECMO has emerged as a salvage intervention in patients with cardiogenic shock, even cardiac arrest refractory to standard therapies. Analogous to veno-venous ECMO for acute respiratory failure, VA-ECMO provides circulatory support and allows time for other treatments to promote recovery or may be a bridge to a more durable mechanical solution in the setting of acute or acute on chronic cardiopulmonary failure...
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354363/clinical-and-in-vitro-evidence-that-left-ventricular-assist-device-induced-von-willebrand-factor-degradation-alters-angiogenesis
#15
Carlo R Bartoli, David M Zhang, Samson Hennessy-Strahs, Jooeun Kang, David J Restle, Christian Bermudez, Pavan Atluri, Michael A Acker
Background Gastrointestinal bleeding from angiodysplasia is a major problem in continuous-flow left ventricular assist device (LVAD) patients. LVAD shear stress causes pathologic degradation of VWF (von Willebrand factor). A mechanistic relationship between VWF degradation and angiodysplasia has not been explored. We tested 2 novel hypotheses: (1) clinical hypothesis: VWF fragments are elevated in LVAD patients that develop angiodysplasia and (2) in vitro hypothesis: VWF fragments generated during LVAD support alter angiogenesis, which may contribute to angiodysplasia...
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354362/effect-of-everolimus-initiation-and-calcineurin-inhibitor-elimination-on-cardiac-allograft-vasculopathy-in-de-novo-heart-transplant-recipients
#16
Satish Arora, Arne K Andreassen, Kristjan Karason, Finn Gustafsson, Hans Eiskjær, Hans Erik Bøtker, Göran Rådegran, Einar Gude, Dan Ioanes, Dag Solbu, Göran Dellgren, Thor Ueland, Pål Aukrust, Lars Gullestad
Background Cardiac allograft vasculopathy (CAV) limits survival after heart transplantation, and the effect of different immunosuppressive regimens on CAV is not fully understood. The randomized SCHEDULE trial (Scandinavian Heart Transplant Everolimus De Novo Study With Early Calcineurin Inhibitors Avoidance) evaluated whether initiation of the proliferation signal inhibitor everolimus and early cyclosporine elimination can reduce CAV development. Methods and Results The SCHEDULE trial was a multicenter Scandinavian trial, where 115 de novo heart transplantation recipients were randomized to everolimus with complete cyclosporine withdrawal 7 to 11 weeks after heart transplantation or standard cyclosporine-based immunosuppression...
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354361/skeletal-muscle-abnormalities-and-iron-deficiency-in-chronic-heart-failure-an-exercise-31-p-magnetic-resonance-spectroscopy-study-of-calf-muscle
#17
Vojtech Melenovsky, Katerina Hlavata, Petr Sedivy, Monika Dezortova, Barry A Borlaug, Jiri Petrak, Josef Kautzner, Milan Hajek
BACKGROUND: Heart failure (HF) is often associated with iron deficiency (ID). Skeletal muscle abnormalities are common in HF, but the potential role of ID in this phenomenon is unclear. In addition to hemopoiesis, iron is essential for muscle bioenergetics. We examined whether energetic abnormalities in skeletal muscle in HF are affected by ID and if they are responsive to intravenous iron. METHODS AND RESULTS: Forty-four chronic HF subjects and 25 similar healthy volunteers underwent 31 P magnetic resonance spectroscopy of calf muscle at rest and during exercise (plantar flexions)...
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354360/patient-provider-and-practice-characteristics-associated-with-sacubitril-valsartan-use-in-the-united-states
#18
Adam D DeVore, C Larry Hill, Laine Thomas, Puza P Sharma, Nancy M Albert, Javed Butler, J Herbert Patterson, John A Spertus, Fredonia B Williams, Carol I Duffy, Kevin McCague, Adrian F Hernandez, Gregg C Fonarow
Background Current guidelines recommend sacubitril/valsartan for patients with heart failure with reduced ejection fraction, but the rate of adoption in the United States has been slow. Methods and Results Using data from CHAMP-HF (Change the Management of Patients With Heart Failure), we described current sacubitril/valsartan use and identified patient, provider, and practice characteristics associated with its use. We considered patients to be on sacubitril/valsartan if they were prescribed it before enrollment or initiated on it at the baseline visit...
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354359/venoarterial-extracorporeal-membrane-oxygenation-in-the-new-heart-allocation-scheme
#19
Muddassir Mehmood
No abstract text is available yet for this article.
September 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30354570/eat-to-treat-heart-failure
#20
EDITORIAL
Linda Van Horn, Mark D Huffman
No abstract text is available yet for this article.
August 2018: Circulation. Heart Failure
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