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Circulation. Heart Failure

journal
https://www.readbyqxmd.com/read/29330154/novel-wearable-seismocardiography-and-machine-learning-algorithms-can-assess-clinical-status-of-heart-failure-patients
#1
Omer T Inan, Maziyar Baran Pouyan, Abdul Q Javaid, Sean Dowling, Mozziyar Etemadi, Alexis Dorier, J Alex Heller, A Ozan Bicen, Shuvo Roy, Teresa De Marco, Liviu Klein
BACKGROUND: Remote monitoring of patients with heart failure (HF) using wearable devices can allow patient-specific adjustments to treatments and thereby potentially reduce hospitalizations. We aimed to assess HF state using wearable measurements of electrical and mechanical aspects of cardiac function in the context of exercise. METHODS AND RESULTS: Patients with compensated (outpatient) and decompensated (hospitalized) HF were fitted with a wearable ECG and seismocardiogram sensing patch...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29330153/heart-failure-in-pregnant-women-a-concern-across-the-pregnancy-continuum
#2
Mulubrhan F Mogos, Mariann R Piano, Barbara L McFarlin, Jason L Salemi, Kylea L Liese, Joan E Briller
BACKGROUND: Heart failure (HF) is a leading cause of maternal morbidity and mortality in the United States, but prevalence, correlates, and outcomes of HF-related hospitalization during antepartum, delivery, and postpartum periods remain unknown. The objective was to examine HF prevalence, correlates, and outcomes among pregnancy-related hospitalizations among women 13 to 49 years of age. METHODS AND RESULTS: We used the 2001 to 2011 Nationwide Inpatient Sample...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29321133/evolving-story-of-clinical-trials-in-hypertrophic-cardiomyopathy
#3
EDITORIAL
Perry M Elliott
No abstract text is available yet for this article.
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29321132/intersection-of-pulmonary-hypertension-and-right-ventricular-dysfunction-in-patients-on-left-ventricular-assist-device-support-is-there-a-role-for-pulmonary-vasodilators
#4
Christopher T Sparrow, Shane J LaRue, Joel D Schilling
Left ventricular assist devices (LVADs) improve survival and quality of life in patients with advanced heart failure. Despite these benefits, combined post- and precapillary pulmonary hypertension can be particularly problematic in patients on LVAD support, often exacerbating right ventricular (RV) dysfunction. Both persistently elevated pulmonary vascular resistance and RV dysfunction are associated with adverse outcomes, including death after LVAD. These observations have led to significant interest in the use of pulmonary vasodilators to treat pulmonary hypertension and preserve RV function among LVAD-supported patients...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29321131/efficacy-of-ranolazine-in-patients-with-symptomatic-hypertrophic-cardiomyopathy-the-restyle-hcm-randomized-double-blind-placebo-controlled-study
#5
Iacopo Olivotto, Paolo G Camici, Piera Angelica Merlini, Claudio Rapezzi, Monica Patten, Vicent Climent, Gianfranco Sinagra, Benedetta Tomberli, Francisco Marin, Philipp Ehlermann, Lars S Maier, Alessandra Fornaro, Claudius Jacobshagen, Antonello Ganau, Luciano Moretti, Antonio Hernandez Madrid, Raffaele Coppini, Giorgio Reggiardo, Corrado Poggesi, Francesco Fattirolli, Luiz Belardinelli, Gianfranco Gensini, Alessandro Mugelli
BACKGROUND: The late sodium current inhibitor ranolazine reverses the main electrophysiological and mechanical abnormalities of human hypertrophic cardiomyopathy (HCM) cardiomyocytes in vitro, suggesting potential clinical benefit. We aimed to assess the effect of ranolazine on functional capacity, symptomatic status, diastolic function, and arrhythmias in HCM. METHODS AND RESULTS: In this multicenter, double-blind, phase 2 study, 80 adult patients with nonobstructive HCM (age 53±14 years, 34 women) were randomly assigned to placebo (n=40) or ranolazine 1000 mg bid (n=40) for 5 months...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29321130/exercise-hemodynamic-and-functional-capacity-after-mitral-valve-replacement-in-patients-with-ischemic-mitral-regurgitation-a-comparison-of-mechanical-versus-biological-prostheses
#6
Carlo Fino, Attilio Iacovoni, Philippe Pibarot, John R Pepper, Paolo Ferrero, Maurizio Merlo, Lorenzo Galletti, Massimo Caputo, Paolo Ferrazzi, Constantinos Anagnostopoulos, Diego Cugola, Michele Senni, Diego Bellavia, Julien Magne
BACKGROUND: In patients with ischemic mitral regurgitation requiring mitral valve replacement (MVR), the choice of the prosthesis type is crucial. The exercise hemodynamic and functional capacity performance in patients with contemporary prostheses have never been investigated. To compare exercise hemodynamic and functional capacity between biological (MVRb) and mechanical (MVRm) prostheses. METHODS AND RESULTS: We analyzed 86 consecutive patients with ischemic mitral regurgitation who underwent MVRb (n=41) or MVRm (n=45) and coronary artery bypass grafting...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29317402/skeletal-muscle-compensation-for-cardiac-muscle-insufficiency-in-heart-failure-and-reduced-ejection-fraction
#7
Yogesh N V Reddy, Masaru Obokata, Mark J Haykowsky, Barry A Borlaug
No abstract text is available yet for this article.
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29317401/acute-and-chronic-increases-of-circulating-fstl1-normalize-energy-substrate-metabolism-in-pacing-induced-heart-failure
#8
Mitsuru Seki, Jeffery C Powers, Sonomi Maruyama, Maria A Zuriaga, Chia-Ling Wu, Clara Kurishima, Lydia Kim, Jesse Johnson, Anthony Poidomani, Tao Wang, Eric Muñoz, Sudarsan Rajan, Joon Y Park, Kenneth Walsh, Fabio A Recchia
BACKGROUND: FSTL1 (follistatin-like protein 1) is an emerging cardiokine/myokine that is upregulated in heart failure (HF) and is found to be cardioprotective in animal models of cardiac injury. We tested the hypothesis that circulating FSTL1 can affect cardiac function and metabolism under baseline physiological conditions and in HF. METHODS AND RESULTS: FSTL1 was acutely (10 minutes) or chronically (2 weeks) infused to attain clinically relevant blood levels in conscious dogs with cardiac tachypacing-induced HF...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29246898/the-heart-transplant-waiting-list-and-the-interplay-of-policy-and-practice-in-search-of-fairness
#9
EDITORIAL
Josef Stehlik, Omar Wever-Pinzon
No abstract text is available yet for this article.
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29246897/hemodynamics-of-fontan-failure-the-role-of-pulmonary-vascular-disease
#10
Alexander C Egbe, Heidi M Connolly, William R Miranda, Naser M Ammash, Donald J Hagler, Gruschen R Veldtman, Barry A Borlaug
BACKGROUND: Nonpulsatile pulmonary blood flow in Fontan circulation results in pulmonary vascular disease, but the potential relationships between pulmonary vascular resistance index (PVRI) and Fontan failure have not been studied. The objective was to determine whether the absence of subpulmonary ventricle in the Fontan circulation would make patients more vulnerable to even low-level elevations in PVRI, and when coupled with low cardiac index, this would identify patients at increased risk of Fontan failure...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29246896/trends-in-the-use-of-inotropes-to-list-adult-heart-transplant-candidates-at-status-1a
#11
MULTICENTER STUDY
William F Parker, Edward R Garrity, Savitri Fedson, Matthew M Churpek
BACKGROUND: The number of adult heart transplant candidates waiting at the most urgent status 1A has increased over time despite the expansion of geographic sharing of hearts in 2006. We aimed to determine whether candidates listed with inotropes contribute to the excess status 1A candidates. METHODS AND RESULTS: The initial registrations of all adult heart-only candidates listed from 2000 to 2015 were analyzed using the Scientific Registry of Transplant Recipients data set...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29242353/cardiac-specific-bdh1-overexpression-ameliorates-oxidative-stress-and-cardiac-remodeling-in-pressure-overload-induced-heart-failure
#12
Motoki Uchihashi, Atsushi Hoshino, Yoshifumi Okawa, Makoto Ariyoshi, Satoshi Kaimoto, Shuhei Tateishi, Kazunori Ono, Ryoetsu Yamanaka, Daichi Hato, Yohei Fushimura, Sakiko Honda, Kuniyoshi Fukai, Yusuke Higuchi, Takehiro Ogata, Eri Iwai-Kanai, Satoaki Matoba
BACKGROUND: Energy starvation and the shift of energy substrate from fatty acids to glucose is the hallmark of metabolic remodeling during heart failure progression. However, ketone body metabolism in the failing heart has not been fully investigated. METHODS AND RESULTS: Microarray data analysis and mitochondrial isobaric tags for relative and absolute quantification proteomics revealed that the expression of D-β-hydroxybutyrate dehydrogenase I (Bdh1), an enzyme that catalyzes the NAD+/NADH coupled interconversion of acetoacetate and β-hydroxybutyrate, was increased 2...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29242352/predicting-risk-in-patients-hospitalized-for-acute-decompensated-heart-failure-and-preserved-ejection-fraction-the-atherosclerosis-risk-in-communities-study-heart-failure-community-surveillance
#13
MULTICENTER STUDY
Tonje Thorvaldsen, Brian L Claggett, Amil Shah, Susan Cheng, Sunil K Agarwal, Lisa M Wruck, Patricia P Chang, Wayne D Rosamond, Eldrin F Lewis, Akshay S Desai, Lars H Lund, Scott D Solomon
BACKGROUND: Risk-prediction models specifically for hospitalized heart failure with preserved ejection fraction are lacking. METHODS AND RESULTS: We analyzed data from the ARIC (Atherosclerosis Risk in Communities) Study Heart Failure Community Surveillance to create and validate a risk score predicting mortality in patients ≥55 years of age admitted with acute decompensated heart failure with preserved ejection fraction (ejection fraction ≥50%). A modified version of the risk-prediction model for acute heart failure developed from patients in the EFFECT (Enhanced Feedback for Effective Cardiac Treatment) study was used as a composite predictor of 28-day and 1-year mortalities and evaluated together with other potential predictors in a stepwise logistic regression...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29237711/breaking-the-law-of-small-numbers
#14
EDITORIAL
Peter S Pang, Christopher S Weaver
No abstract text is available yet for this article.
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29237710/short-term-outcomes-and-factors-associated-with-adverse-events-among-adults-discharged-from-the-emergency-department-after-treatment-for-acute-heart-failure
#15
MULTICENTER STUDY
Dana R Sax, Dustin G Mark, Renee Y Hsia, Thida C Tan, Grace H Tabada, Alan S Go
BACKGROUND: Although 80% of patients with heart failure seen in the emergency department (ED) are admitted, less is known about short-term outcomes and demand for services among discharged patients. METHODS AND RESULTS: We examined adult members of a large integrated delivery system who visited an ED for acute heart failure and were discharged from January 1, 2013, through September 30, 2014. The primary outcome was a composite of repeat ED visit, hospital admission, or death within 7 days of discharge...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29237709/peer-review-of-a-manuscript-submission-a-how-to-guide-for-effective-and-efficient-commentary
#16
Larry A Allen, P Michael Ho
No abstract text is available yet for this article.
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29217758/targeting-myocardial-energetics-in-the-failing-heart-are-we-there-yet
#17
EDITORIAL
Douglas L Mann
No abstract text is available yet for this article.
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29217757/novel-mitochondria-targeting-peptide-in-heart-failure-treatment-a-randomized-placebo-controlled-trial-of-elamipretide
#18
RANDOMIZED CONTROLLED TRIAL
Melissa A Daubert, Eric Yow, Gary Dunn, Sotir Marchev, Huiman Barnhart, Pamela S Douglas, Christopher O'Connor, Sidney Goldstein, James E Udelson, Hani N Sabbah
BACKGROUND: Mitochondrial dysfunction and energy depletion in the failing heart are innovative therapeutic targets in heart failure management. Elamipretide is a novel tetrapeptide that increases mitochondrial energy; however, its safety, tolerability, and therapeutic effect on cardiac structure and function have not been studied in heart failure with reduced ejection fraction. METHODS AND RESULTS: In this double-blind, placebo-controlled, ascending-dose trial, patients with heart failure with reduced ejection fraction (ejection fraction, ≤35%) were randomized to either a single 4-hour infusion of elamipretide (cohort 1 [n=8], 0...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29203563/detection-of-urinary-mulberry-bodies-leads-to-diagnosis-of-fabry-cardiomyopathy-a-simple-clue-in-the-urine-sediment
#19
Toshiyuki Yano, Ryo Takahashi, Tomohisa Yamashita, Nobutaka Nagano, Aki Ishikawa, Akihiro Sakurai, Hiroki Maruyama, Tetsuji Miura
No abstract text is available yet for this article.
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29203562/impaired-protein-quality-control-during-left-ventricular-remodeling-in-mice-with-cardiac-restricted-overexpression-of-tumor-necrosis-factor
#20
Justin Hartupee, Gabor D Szalai, Wei Wang, Xiucui Ma, Abhinav Diwan, Douglas L Mann
BACKGROUND: Sustained inflammation in the heart is sufficient to provoke left ventricular dysfunction and left ventricular remodeling. Although inflammation has been linked to many of the biological changes responsible for adverse left ventricular remodeling, the relationship between inflammation and protein quality control in the heart is not well understood. METHODS AND RESULTS: To study the relationship between chronic inflammation and protein quality control, we used a mouse model of dilated cardiomyopathy driven by cardiac restricted overexpression of TNF (tumor necrosis factor; Myh6-sTNF)...
December 2017: Circulation. Heart Failure
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