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Circulation. Heart Failure

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https://www.readbyqxmd.com/read/29748350/prognostic-significance-of-creatinine-increases-during-an-acute-heart-failure-admission-in-patients-with-and-without-residual-congestion-a-post-hoc-analysis-of-the-protect-data
#1
Marco Metra, Gad Cotter, Stefanie Senger, Christopher Edwards, John G Cleland, Piotr Ponikowski, Guillermo C Cursack, Olga Milo, John R Teerlink, Michael M Givertz, Christopher M O'Connor, Howard C Dittrich, Daniel M Bloomfield, Adriaan A Voors, Beth A Davison
BACKGROUND: The importance of a serum creatinine increase, traditionally considered worsening renal function (WRF), during admission for acute heart failure has been recently debated, with data suggesting an interaction between congestion and creatinine changes. METHODS AND RESULTS: In post hoc analyses, we analyzed the association of WRF with length of hospital stay, 30-day death or cardiovascular/renal readmission and 90-day mortality in the PROTECT study (Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function)...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29748349/independent-prognostic-value-of-serum-soluble-st2-measurements-in-patients-with-heart-failure-and-a-reduced-ejection-fraction-in-the-paradigm-hf-trial-prospective-comparison-of-arni-with-acei-to-determine-impact-on-global-mortality-and-morbidity-in-heart-failure
#2
Eileen O'Meara, Margaret F Prescott, Brian Claggett, Jean L Rouleau, Lu-May Chiang, Scott D Solomon, Milton Packer, John J V McMurray, Michael R Zile
BACKGROUND: Soluble ST2 (sST2) is associated with cardiac remodeling and fibrosis. In chronic heart failure, the predictive value of sST2 has not been evaluated in a model that includes both NT-proBNP (N-terminal pro-B-type natriuretic peptide) and hs-TnT (high-sensitivity cardiac troponin T), in a trial in which treatment had a major impact. Therefore, the effects of treatment on sST2 levels in PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the relationships between sST2 and outcomes, and the prognostic utility of various sST2 partition values were examined...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29739746/dog-model-holds-promise-for-early-mechanical-unloading-in-patients-with-acute-myocardial-infarction
#3
EDITORIAL
Cesar Y Guerrero-Miranda, Shelley A Hall
No abstract text is available yet for this article.
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29739745/left-ventricular-mechanical-unloading-by-total-support-of-impella-in-myocardial-infarction-reduces-infarct-size-preserves-left-ventricular-function-and-prevents-subsequent-heart-failure-in-dogs
#4
Keita Saku, Takamori Kakino, Takahiro Arimura, Genya Sunagawa, Takuya Nishikawa, Takafumi Sakamoto, Takuya Kishi, Hiroyuki Tsutsui, Kenji Sunagawa
BACKGROUND: Acute myocardial infarction remains a leading cause of chronic heart failure. Excessive myocardial oxygen demand relative to supply is the fundamental mechanism of myocardial infarction. We thus hypothesized that left ventricular (LV) mechanical unloading by the total support of transvascular LV assist device Impella could minimize oxygen demand, thereby reducing infarct size and preventing subsequent heart failure. METHODS AND RESULTS: In 20 dogs, we ligated the left anterior descending coronary artery for 180 minutes and then reperfused...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29724722/coronary-artery-remodeling-and-fibrosis-with-continuous-flow-left-ventricular-assist-device-support
#5
Amrut V Ambardekar, Mary C M Weiser-Evans, Marcella Li, Suneet N Purohit, Muhammad Aftab, T Brett Reece, Karen S Moulton
BACKGROUND: Coronary artery fluid dynamics may be altered because of the nonphysiological flow seen in continuous-flow left ventricular assist devices (CF-LVADs). Our aim was to study the structure and composition of coronary vessels after CF-LVAD. METHODS AND RESULTS: Coronary arteries were collected from patients with heart failure (HF) at the time of transplantation, of whom 15 were supported with a CF-LVAD before transplant (HF+LVAD group) and 9 were not (HF non-LVAD group)...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29716899/risk-factor-burden-heart-failure-and-survival-in-women-of-different-ethnic-groups-insights-from-the-women-s-health-initiative
#6
Khadijah Breathett, Iris Leng, Randi E Foraker, William T Abraham, Laura Coker, Keith E Whitfield, Sally Shumaker, JoAnn E Manson, Charles B Eaton, Barbara V Howard, Nkechinyere Ijioma, Crystal W Cené, Lisa W Martin, Karen C Johnson, Liviu Klein
BACKGROUND: The higher risk of heart failure (HF) in African-American and Hispanic women compared with white women is related to the higher burden of risk factors (RFs) in minorities. However, it is unclear if there are differences in the association between the number of RFs for HF and the risk of development of HF and death within racial/ethnic groups. METHODS AND RESULTS: In the WHI (Women's Health Initiative; 1993-2010), African-American (n=11 996), white (n=18 479), and Hispanic (n=5096) women with 1, 2, or 3+ baseline RFs were compared with women with 0 RF within their respective racial/ethnic groups to assess risk of developing HF or all-cause mortality before and after HF, using survival analyses...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29716898/load-dependent-changes-in-left-ventricular-structure-and-function-in-a-pathophysiologically-relevant-murine-model-of-reversible-heart-failure
#7
Carla J Weinheimer, Attila Kovacs, Sarah Evans, Scot J Matkovich, Philip M Barger, Douglas L Mann
BACKGROUND: To better understand reverse left ventricular (LV) remodeling, we developed a murine model wherein mice develop LV remodeling after transverse aortic constriction (TAC) and a small apical myocardial infarct (MI) and undergo reverse LV remodeling after removal of the aortic band. METHODS AND RESULTS: Mice studied were subjected to sham (n=6) surgery or TAC+MI (n=12). Two weeks post-TAC+MI, 1 group underwent debanding (referred to as heart failure debanding [HF-DB] mice; n=6), whereas the aortic band remained in a second group (heart failure [HF] group; n=6)...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29695382/internal-versus-external-compression-of-a-left-ventricular-assist-device-outflow-graft-diagnosis-with-intravascular-ultrasound-and-treatment-with-stenting
#8
Cory R Trankle, Mohammed A Quader, John D Grizzard, Daniel G Tang, Keyur B Shah, Kendall Paris, Christina K Shepard, Zachary M Gertz
No abstract text is available yet for this article.
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29695381/pulmonary-capillary-wedge-pressure-patterns-during-exercise-predict-exercise-capacity-and-incident-heart-failure
#9
Aaron S Eisman, Ravi V Shah, Bishnu P Dhakal, Paul P Pappagianopoulos, Luke Wooster, Cole Bailey, Thomas F Cunningham, Kathryn M Hardin, Aaron L Baggish, Jennifer E Ho, Rajeev Malhotra, Gregory D Lewis
BACKGROUND: Single measurements of left ventricular filling pressure at rest lack sensitivity for identifying heart failure with preserved ejection fraction (HFpEF) in patients with dyspnea on exertion. We hypothesized that exercise hemodynamic measurements (ie, changes in pulmonary capillary wedge pressure [PCWP] indexed to cardiac output [CO]) may more sensitively differentiate HFpEF and non-HFpEF disease states, reflect aerobic capacity, and forecast heart failure outcomes in individuals with normal PCWP at rest...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29691235/correction-to-2017-acc-aha-hfsa-ishlt-acp-advanced-training-statement-on-advanced-heart-failure-and-transplant-cardiology-revision-of-the-accf-aha-acp-hfsa-ishlt-2010-clinical-competence-statement-on-management-of-patients-with-advanced-heart-failure-and-cardiac
#10
https://www.readbyqxmd.com/read/29666074/when-the-vest-does-not-fit-representations-of-trial-results-deviating-from-rigorous-data-interpretation
#11
Larry A Allen, Eric D Adler, Antoni Bayés-Genis, Meredith A Brisco-Bacik, Julio A Chirinos, Brian Claggett, Jennifer L Cook, James C Fang, Finn Gustafsson, Carolyn Y Ho, Navin K Kapur, Scott E Klewer, Robb D Kociol, David E Lanfear, Orly Vardeny, Nancy K Sweitzer
No abstract text is available yet for this article.
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29666073/ventricular-assist-device-utilization-in-heart-transplant-candidates-nationwide-variability-and-impact-on-waitlist-outcomes
#12
Lauren K Truby, A Reshad Garan, Raymond C Givens, Koji Takeda, Hiroo Takayama, Pauline N Trinh, Melana Yuzefpolskaya, Maryjane A Farr, Yoshifumi Naka, Paolo C Colombo, Veli K Topkara
BACKGROUND: Continuous-flow left ventricular assist devices (CF-LVADs) have become a standard treatment choice in advanced heart failure patients. We hypothesized that practice patterns with regards to CF-LVAD utilization vary significantly among transplant centers and impact waitlist outcomes. METHODS AND RESULTS: The United Network for Organ Sharing registry was queried to identify adult patients who were waitlisted for heart transplantation (HT) between 2008 and 2015...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29666072/left-ventricular-assist-device-inflow-cannula-angle-and-thrombosis-risk
#13
Venkat Keshav Chivukula, Jennifer A Beckman, Anthony R Prisco, Todd Dardas, Shin Lin, Jason W Smith, Nahush A Mokadam, Alberto Aliseda, Claudius Mahr
BACKGROUND: As heart failure prevalence continues to increase in the setting of a static donor supply, left ventricular assist device (LVAD) therapy for end-stage heart failure continues to grow. Anecdotal evidence suggests that malalignment of the LVAD inflow cannula may increase thrombosis risk, but this effect has not been explored mechanistically or quantified statistically. Our objective is to elucidate the impact of surgical angulation of the inflow cannula on thrombogenicity. METHODS AND RESULTS: Unsteady computational fluid dynamics is used in conjunction with computational modeling and virtual surgery to model flow through the left ventricle for 5 different inflow cannula angulations...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29643067/incidence-predictors-and-outcomes-associated-with-hypotensive-episodes-among-heart-failure-patients-receiving-sacubitril-valsartan-or-enalapril-the-paradigm-hf-trial-prospective-comparison-of-angiotensin-receptor-neprilysin-inhibitor-with-angiotensin-converting
#14
Orly Vardeny, Brian Claggett, Jessica Kachadourian, Scott M Pearson, Akshay S Desai, Milton Packer, Jean Rouleau, Michael R Zile, Karl Swedberg, Martin Lefkowitz, Victor Shi, John J V McMurray, Scott D Solomon
BACKGROUND: In PARADIGM-HF (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure), heart failure treatment with sacubitril/valsartan reduced the primary composite outcome of cardiovascular death or heart failure hospitalization compared with enalapril but resulted in more symptomatic hypotension. Concern on hypotension may be limiting use of sacubitril/valsartan in appropriate patients...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29643066/early-ambulation-among-hospitalized-heart-failure-patients-is-associated-with-reduced-length-of-stay-and-30-day-readmissions
#15
Lisa M Fleming, Xin Zhao, Adam D DeVore, Paul A Heidenreich, Clyde W Yancy, Gregg C Fonarow, Adrian F Hernandez, Robb D Kociol
BACKGROUND: Early ambulation (EA) is associated with improved outcomes for mechanically ventilated and stroke patients. Whether the same association exists for patients hospitalized with acute heart failure is unknown. We sought to determine whether EA among patients hospitalized with heart failure is associated with length of stay, discharge disposition, 30-day post discharge readmissions, and mortality. METHODS AND RESULTS: The study population included 369 hospitals and 285 653 patients with heart failure enrolled in the Get With The Guidelines-Heart Failure registry...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29643065/pulmonary-effective-arterial-elastance-as-a-measure-of-right-ventricular-afterload-and-its-prognostic-value-in-pulmonary-hypertension-due-to-left-heart-disease
#16
Emmanouil Tampakakis, Sanjiv J Shah, Barry A Borlaug, Peter J Leary, Harnish H Patel, Wayne L Miller, Benjamin W Kelemen, Brian A Houston, Todd M Kolb, Rachel Damico, Stephen C Mathai, Edward K Kasper, Paul M Hassoun, David A Kass, Ryan J Tedford
BACKGROUND: Patients with combined post- and precapillary pulmonary hypertension due to left heart disease have a worse prognosis compared with isolated postcapillary. However, it remains unclear whether increased mortality in combined post- and precapillary pulmonary hypertension is simply a result of higher total right ventricular load. Pulmonary effective arterial elastance (Ea) is a measure of total right ventricular afterload, reflecting both resistive and pulsatile components. We aimed to test whether pulmonary Ea discriminates survivors from nonsurvivors in patients with pulmonary hypertension due to left heart disease and if it does so better than other hemodynamic parameters associated with combined post- and precapillary pulmonary hypertension...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29626101/advanced-dilated-cardiomyopathy-in-a-patient-with-hutterite-limb-girdle-muscular-dystrophy-use-of-a-left-ventricular-assist-device
#17
Bailey Miskew Nichols, Anish Nikhanj, Faqi Wang, Darren H Freed, Gavin Y Oudit
No abstract text is available yet for this article.
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29626100/devil-in-disguise-hints-and-pitfalls-in-diagnosis-of-peripartum-cardiomyopathy
#18
EDITORIAL
Johann Bauersachs, Tobias Koenig
No abstract text is available yet for this article.
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29626099/incidence-risk-factors-and-clinical-characteristics-of-peripartum-cardiomyopathy-in-south-korea
#19
Sunki Lee, Geum Joon Cho, Geun U Park, Log Young Kim, Tae-Seon Lee, Do Young Kim, Suk-Won Choi, Jong-Chan Youn, Seong Woo Han, Kyu-Hyung Ryu, Jin Oh Na, Cheol Ung Choi, Hong Seog Seo, Eung Ju Kim
BACKGROUND: Peripartum cardiomyopathy (PPCM) is a rare disorder associated with pregnancy that can lead to life-threatening conditions. The incidence and clinical characteristics of this condition remain poorly understood. METHODS AND RESULTS: We aimed to perform the first population-based study of PPCM in South Korea, using the Korea National Health Insurance Claims Database of the Health Insurance Review and Assessment Service. Patients who fulfilled predefined diagnostic criteria for PPCM from January 1, 2010, to December 31, 2012, were identified from International Classification of Diseases, Tenth Revision, Clinical Modification codes...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29618581/causes-and-predictors-of-30-day-readmission-in-patients-with-acute-myocardial-infarction-and-cardiogenic-shock
#20
Mahek Shah, Shantanu Patil, Brijesh Patel, Manyoo Agarwal, Carlos D Davila, Lohit Garg, Sahil Agrawal, Navin K Kapur, Ulrich P Jorde
BACKGROUND: Acute myocardial infarction (AMI) occurs as a result of irreversible damage to cardiac myocytes secondary to lack of blood supply. Cardiogenic shock complicating AMI has significant associated morbidity and mortality, and data on postdischarge outcomes are limited. METHODS AND RESULTS: We derived the study cohort of patients with AMI and cardiogenic shock from the 2013 to 2014 Healthcare Cost and Utilization Project National Readmission Database. Incidence, predictors, and causes of 30-day readmissions were analyzed...
April 2018: Circulation. Heart Failure
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