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Circulation. Heart Failure

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https://www.readbyqxmd.com/read/28404627/multiphasic-regulation-of-systemic-and-peripheral-organ-metabolic-responses-to-cardiac-hypertrophy
#1
Chong Wee Liew, Shanshan Xu, Xuerong Wang, Maximilian McCann, Hyerim Whang Kong, Andrew C Carley, Jingbo Pang, Giamila Fantuzzi, J Michael O'Donnell, E Douglas Lewandowski
BACKGROUND: Reduced fat oxidation in hypertrophied hearts coincides with a shift of carnitine palmitoyl transferase I from muscle to increased liver isoforms. Acutely increased carnitine palmitoyl transferase I in normal rodent hearts has been shown to recapitulate the reduced fat oxidation and elevated atrial natriuretic peptide message of cardiac hypertrophy. METHODS AND RESULTS: Because of the potential for reduced fat oxidation to affect cardiac atrial natriuretic peptide, and thus, induce adipose lipolysis, we studied peripheral and systemic metabolism in male C57BL/6 mice model of transverse aortic constriction in which left ventricular hypertrophy occurred by 2 weeks without functional decline until 16 weeks (ejection fraction, -45...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28404626/adenosine-formed-by-cd73-on-t-cells-inhibits-cardiac-inflammation-and-fibrosis-and-preserves-contractile-function-in-transverse-aortic-constriction-induced-heart-failure
#2
Christine Quast, Christina Alter, Zhaoping Ding, Nadine Borg, Jürgen Schrader
BACKGROUND: Structural damage during heart failure development leads to increased infiltration of leukocytes. Because purinergic signaling on immune cells may impact on the inflammatory response, we evaluated the role of ecto-5'-nucleotidase (CD73) on the development of heart failure after transverse aortic constriction (TAC) using global and T-cell-specific CD73(-)(/-) mice. METHODS AND RESULTS: Leukocytes infiltrating the failing heart were analyzed by a multistep enzymatic procedure over a period of 16 weeks using fluorescence-activated cell sorting...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28396502/pericardiectomy-to-treat-heart-failure-with-preserved-ejection-fraction-unrestrained-enthusiasm
#3
EDITORIAL
Martin M LeWinter
No abstract text is available yet for this article.
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28396501/mechanism-of-progressive-heart-failure-and-significance-of-pulmonary-hypertension-in-obstructive-hypertrophic-cardiomyopathy
#4
Michele Covella, Ethan J Rowin, Nicholas S Hill, Ioana R Preston, Alberto Milan, Alexander R Opotowsky, Barry J Maron, Martin S Maron, Bradley A Maron
BACKGROUND: There are limited data on the prevalence, pathophysiology, and management implications of pulmonary hypertension in patients with obstructive hypertrophic cardiomyopathy and advanced heart failure. METHODS AND RESULTS: To assess the clinical significance of measured cardiopulmonary hemodynamics in hypertrophic cardiomyopathy patients with heart failure, we retrospectively assessed right heart catheterization data in 162 consecutive patients with outflow tract gradients (median [interquartile range], 90 mm Hg [70-110 mm Hg]), 59±11 years old, and 49% men, predominately New York Heart Association class III/IV status...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28396500/percutaneous-pericardial-resection-a-novel-potential-treatment-for-heart-failure-with-preserved-ejection-fraction
#5
Barry A Borlaug, Rickey E Carter, Vojtech Melenovsky, Christopher V DeSimone, Prakriti Gaba, Ammar Killu, Niyada Naksuk, Lilach Lerman, Samuel J Asirvatham
BACKGROUND: People with heart failure and preserved ejection fraction develop increases in left ventricular (LV) end-diastolic pressures during exercise that contribute to dyspnea. In normal open-chest animal preparations, the pericardium restrains LV filling when central blood volume increases. We hypothesized that resection of the pericardium using a minimally invasive epicardial approach would mitigate the increase in LV end-diastolic pressure that develops during volume loading in normal and diseased hearts with the chest intact...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28377441/percutaneous-transfemoral-tricuspid-valve-edge-to-edge-repair-a-case-series
#6
Karin Müller, Rezo Jorbenadze, Tobias Walker, Robert Schüler, Christoph Hammerstingl, Christian Schlensak, Meinrad Gawaz, Harald F Langer, Peter Seizer
No abstract text is available yet for this article.
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28377440/late-migration-of-a-cardiomems-tm-wireless-pulmonary-artery-hemodynamic-monitoring-sensor
#7
Aniket S Rali, Zubair Shah, Andrew Sauer, Kamal Gupta
No abstract text is available yet for this article.
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28377439/association-between-use-of-long-acting-nitrates-and-outcomes-in-heart-failure-with-preserved-ejection-fraction
#8
Shir Lynn Lim, Lina Benson, Ulf Dahlström, Carolyn S P Lam, Lars H Lund
BACKGROUND: Nitrates may be beneficial in heart failure with preserved ejection fraction (HFpEF) by enhancing cGMP signaling and improving hemodynamics, but real-world data on potential efficacy are lacking. METHODS AND RESULTS: We linked the Swedish Heart Failure Registry to national registries with International Classification of Diseases, Tenth Revision comorbidity diagnoses and demographic and socioeconomic data. In HFpEF, defined as left ventricular ejection fraction ≥40%, we derived propensity scores for nitrate use using 52 baseline variables...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28364092/use-of-%C3%AE-blockers-in-pulmonary-hypertension
#9
Frédéric Perros, Frances S de Man, Harm J Bogaard, Fabrice Antigny, Gérald Simonneau, Sébastien Bonnet, Steeve Provencher, Nazzareno Galiè, Marc Humbert
Contrasting with the major attention that left heart failure has received, right heart failure remains understudied both at the preclinical and clinical levels. However, right ventricle failure is a major predictor of outcomes in patients with precapillary pulmonary hypertension because of pulmonary arterial hypertension, and in patients with postcapillary pulmonary hypertension because of left heart disease. In pulmonary hypertension, the status of the right ventricle is one of the most important predictors of both morbidity and mortality...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28364091/effect-of-intensive-blood-pressure-treatment-on-heart-failure-events-in-the-systolic-blood-pressure-reduction-intervention-trial
#10
Bharathi Upadhya, Michael Rocco, Cora E Lewis, Suzanne Oparil, Laura C Lovato, William C Cushman, Jeffrey T Bates, Natalie A Bello, Gerard Aurigemma, Lawrence J Fine, Karen C Johnson, Carlos J Rodriguez, Dominic S Raj, Anjay Rastogi, Leonardo Tamariz, Alan Wiggers, Dalane W Kitzman
BACKGROUND: Acute decompensated heart failure (ADHF) was a frequent common outcome in SPRINT (Systolic Blood Pressure Intervention Trial). We examined whether there was differential reduction in ADHF events from intensive blood pressure [BP] treatment among the 6 key, prespecified subgroups in SPRINT: age ≥75 years, prior cardiovascular disease, chronic kidney disease, women, black race, and 3 levels of baseline systolic BP (≤132 versus >132 to <145 versus ≥145 mm Hg). METHODS AND RESULTS: ADHF was defined as hospitalization for ADHF, confirmed and formally adjudicated by a blinded events committee using standardized protocols...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28356300/reassessing-phase-ii-heart-failure-clinical-trials-consensus-recommendations
#11
Javed Butler, Carine E Hamo, James E Udelson, Christopher O'Connor, Hani N Sabbah, Marco Metra, Sanjiv J Shah, Dalane W Kitzman, John R Teerlink, Harold S Bernstein, Gabriel Brooks, Christophe Depre, Mary M DeSouza, Wilfried Dinh, Mark Donovan, Regina Frische-Danielson, Robert J Frost, Dahlia Garza, Udo-Michael Gohring, Jennifer Hellawell, Judith Hsia, Shiro Ishihara, Patricia Kay-Mugford, Joerg Koglin, Marc Kozinn, Christopher J Larson, Martha Mayo, Li-Ming Gan, Pierrre Mugnier, Sekayi Mushonga, Lothar Roessig, Cesare Russo, Afshin Salsali, Carol Satler, Victor Shi, Barry Ticho, Michael van der Laan, Clyde Yancy, Norman Stockbridge, Mihai Gheorghiade
The increasing burden and the continued suboptimal outcomes for patients with heart failure underlines the importance of continued research to develop novel therapeutics for this disorder. This can only be accomplished with successful translation of basic science discoveries into direct human application through effective clinical trial design and execution that results in a substantially improved clinical course and outcomes. In this respect, phase II clinical trials play a pivotal role in determining which of the multitude of potential basic science discoveries should move to the large and expansive registration trials in humans...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28292824/hospice-enrollment-in-patients-with-advanced-heart-failure-decreases-acute-medical-service-utilization
#12
Cindi K Yim, Yolanda Barrón, Stanley Moore, Chris Murtaugh, Anuradha Lala, Melissa Aldridge, Nathan Goldstein, Laura P Gelfman
BACKGROUND: Patients with advanced heart failure (HF) enroll in hospice at low rates, and data on their acute medical service utilization after hospice enrollment is limited. METHODS AND RESULTS: We performed a descriptive analysis of Medicare fee-for-service beneficiaries, with at least one home health claim between July 1, 2009, and June 30, 2010, and at least 2 HF hospitalizations between July 1, 2009, and December 31, 2009, who subsequently enrolled in hospice between July 1, 2009, and December 31, 2009...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28288988/circulating-biomarkers-of-cardiac-fibrosis-do-we-have-any-and-what-use-are-they
#13
EDITORIAL
A Mark Richards
No abstract text is available yet for this article.
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28288987/plasma-and-cardiac-galectin-3-in-patients-with-heart-failure-reflects-both-inflammation-and-fibrosis-implications-for-its-use-as-a-biomarker
#14
Christian Besler, David Lang, Daniel Urban, Karl-Philipp Rommel, Maximilian von Roeder, Karl Fengler, Stephan Blazek, Reinhard Kandolf, Karin Klingel, Holger Thiele, Axel Linke, Gerhard Schuler, Volker Adams, Philipp Lurz
BACKGROUND: Galectin (Gal)-3 is a β-galactoside-binding lectin and currently intensely studied as a biomarker in heart failure. Gal-3 also exerts proinflammatory effects, at least in extracardiac tissues. Objective of this study was to characterize the relationship of plasma and myocardial Gal-3 levels with cardiac fibrosis and inflammation in patients with nonischemic dilated cardiomyopathy and inflammatory cardiomyopathy (iCMP). METHODS AND RESULTS: Endomyocardial biopsies and blood samples were obtained from patients with newly diagnosed cardiomyopathy and clinical suspicion of myocarditis...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28283502/validation-of-noninvasive-measurement-of-cardiac-output-using-inert-gas-rebreathing-in-a-cohort-of-patients-with-heart-failure-and-reduced-ejection-fraction
#15
Mohamed Hassan, Kerolos Wagdy, Ahmed Kharabish, Peter Philip Selwanos, Ahmed Nabil, Ahmed Elguindy, Amr ElFaramawy, Mahmoud F Elmahdy, Hani Mahmoud, Magdi H Yacoub
BACKGROUND: Cardiac output (CO) is a key indicator of cardiac function in patients with heart failure. No completely accurate method is available for measuring CO in all patients. The objective of this study was to validate CO measurement using the inert gas rebreathing (IGR) method against other noninvasive and invasive methods of CO quantification in a cohort of patients with heart failure and reduced ejection fraction. METHODS AND RESULTS: The study included 97 patients with heart failure and reduced ejection fraction (age 42±15...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28255011/ranolazine-prevents-phenotype-development-in-a-mouse-model-of-hypertrophic-cardiomyopathy
#16
Raffaele Coppini, Luca Mazzoni, Cecilia Ferrantini, Francesca Gentile, Josè Manuel Pioner, Tina Laurino, Lorenzo Santini, Valentina Bargelli, Matteo Rotellini, Gianluca Bartolucci, Claudia Crocini, Leonardo Sacconi, Chiara Tesi, Luiz Belardinelli, Jil Tardiff, Alessandro Mugelli, Iacopo Olivotto, Elisabetta Cerbai, Corrado Poggesi
BACKGROUND: Current therapies are ineffective in preventing the development of cardiac phenotype in young carriers of mutations associated with hypertrophic cardiomyopathy (HCM). Ranolazine, a late Na(+) current blocker, reduced the electromechanical dysfunction of human HCM myocardium in vitro. METHODS AND RESULTS: To test whether long-term treatment prevents cardiomyopathy in vivo, transgenic mice harboring the R92Q troponin-T mutation and wild-type littermates received an oral lifelong treatment with ranolazine and were compared with age-matched vehicle-treated animals...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28255010/heart-failure-incidence-and-mortality-in-the-southern-community-cohort-study
#17
Elvis A Akwo, Edmond K Kabagambe, Thomas J Wang, Frank E Harrell, William J Blot, Michael Mumma, Deepak K Gupta, Loren Lipworth
BACKGROUND: There is a paucity of data on heart failure (HF) incidence among low-income and minority populations. Our objective was to investigate HF incidence and post-HF survival by race and sex among low-income adults in the southeastern United States. METHODS AND RESULTS: Participants were 27 078 white and black men and women enrolled during 2002 to 2009 in the SCCS (Southern Community Cohort Study) who had no history of HF and were receiving Centers for Medicare and Medicaid Services...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28242780/implantation-of-the-heartmate-iii-left-ventricular-assist-device-in-a-giant-left-ventricular-aneurysm-is-left-ventricular-reconstruction-mandatory
#18
Sotirios Spiliopoulos, Andrae Wasler, Friedrich Fruehwald, Klemens Ablasser, Gergana Stoschitzky, Otto Dapunt
No abstract text is available yet for this article.
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28242779/activated-t-lymphocytes-are-essential-drivers-of-pathological-remodeling-in-ischemic-heart-failure
#19
Shyam S Bansal, Mohamed Ameen Ismahil, Mehak Goel, Bindiya Patel, Tariq Hamid, Gregg Rokosh, Sumanth D Prabhu
BACKGROUND: Inappropriately sustained inflammation is a hallmark of chronic ischemic heart failure (HF); however, the pathophysiological role of T lymphocytes is unclear. METHODS AND RESULTS: Permanent coronary ligation was performed in adult C57BL/6 mice. When compared with sham-operated mice, mice with HF (8 weeks after ligation) exhibited the following features: (1) significant (P<0.05) expansion of circulating CD3(+)CD8(+) cytotoxic and CD3(+)CD4(+) helper (Th) T lymphocytes, together with increased Th1, Th2, Th17, and regulatory T-cell (Treg) CD4(+) subsets; (2) significant expansion of CD8(+) and CD4(+) T cells in failing myocardium, with increased Th1, Th2, Th17, and Treg CD4(+) subsets, marked reduction of the Th1/Th2 ratio, augmentation of the Th17/Treg ratio, and upregulation of Th2 cytokines; and (3) significantly increased Th1, Th2, Th17 cells, and Tregs, in the spleen and mediastinal lymph nodes, with expansion of splenic antigen-experienced effector and memory CD4(+) T cells...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28242778/%C3%AE-b-crystallin-reverses-high-diastolic-stiffness-of-failing-human-cardiomyocytes
#20
Constantijn Franssen, Jeroen Kole, René Musters, Nazha Hamdani, Walter J Paulus
BACKGROUND: Cardiomyocytes with a less distensible titin and interstitial collagen contribute to the high diastolic stiffness of failing myocardium. Their relative contributions and mechanisms underlying loss of titin distensibility were assessed in failing human hearts. METHODS AND RESULTS: Left ventricular tissue was procured in patients with aortic stenosis (AS, n=9) and dilated cardiomyopathy (DCM, n=6). Explanted donor hearts (n=8) served as controls. Stretches were performed in myocardial strips, and an extraction protocol differentiated between passive tension (Fpassive) attributable to cardiomyocytes or to collagen...
March 2017: Circulation. Heart Failure
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