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Circulation. Heart Failure

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https://www.readbyqxmd.com/read/28209768/worsening-renal-function-and-mortality-in-heart-failure-causality-or-confounding
#1
EDITORIAL
Jeffrey M Testani, Meredith A Brisco-Bacik
No abstract text is available yet for this article.
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28209767/ideal-cardiovascular-health-cardiovascular-remodeling-and-heart-failure-in-blacks-the-jackson-heart-study
#2
Aferdita Spahillari, Sameera Talegawkar, Adolfo Correa, J Jeffrey Carr, James G Terry, João Lima, Jane E Freedman, Saumya Das, Robb Kociol, Sarah de Ferranti, Donya Mohebali, Stanford Mwasongwe, Katherine L Tucker, Venkatesh L Murthy, Ravi V Shah
BACKGROUND: The lifetime risk of heart failure (HF) is higher in the black population than in other racial groups in the United States. METHODS AND RESULTS: We measured the Life's Simple 7 ideal cardiovascular health metrics in 4195 blacks in the JHS (Jackson Heart Study; 2000-2004). We evaluated the association of Simple 7 metrics with incident HF and left ventricular structure and function by cardiac magnetic resonance (n=1188). Mean age at baseline was 54.4 years (65% women)...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28209766/glycosylated-chromogranin-a-in-heart-failure-implications-for-processing-and-cardiomyocyte-calcium-homeostasis
#3
Anett Hellebø Ottesen, Cathrine R Carlson, William E Louch, Mai Britt Dahl, Ragnhild A Sandbu, Rune Forstrøm Johansen, Hilde Jarstadmarken, Magnar Bjørås, Arne Didrik Høiseth, Jon Brynildsen, Ivar Sjaastad, Mats Stridsberg, Torbjørn Omland, Geir Christensen, Helge Røsjø
BACKGROUND: Chromogranin A (CgA) levels have previously been found to predict mortality in heart failure (HF), but currently no information is available regarding CgA processing in HF and whether the CgA fragment catestatin (CST) may directly influence cardiomyocyte function. METHODS AND RESULTS: CgA processing was characterized in postinfarction HF mice and in patients with acute HF, and the functional role of CST was explored in experimental models. Myocardial biopsies from HF, but not sham-operated mice, demonstrated high molecular weight CgA bands...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28209765/renin-angiotensin-system-inhibition-worsening-renal-function-and-outcome-in-heart-failure-patients-with-reduced-and-preserved-ejection-fraction-a-meta-analysis-of-published-study-data
#4
Iris E Beldhuis, Koen W Streng, Jozine M Ter Maaten, Adriaan A Voors, Peter van der Meer, Patrick Rossignol, John J V McMurray, Kevin Damman
BACKGROUND: Renin-angiotensin aldosterone system (RAAS) inhibitors significantly improve outcome in heart failure (HF) patients with reduced ejection fraction (HFREF), irrespective of the occurrence of worsening renal function (WRF). However, in HF patients with preserved ejection fraction (HFPEF), RAAS inhibitors have not been shown to improve outcome but are still frequently prescribed. METHODS AND RESULTS: Random effect meta-analysis was performed to investigate the relationship between RAAS inhibitor therapy, WRF in both HF phenotypes, and mortality...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28209764/kcnj11-ablation-is-associated-with-increased-nitro-oxidative-stress-during-ischemia-reperfusion-injury-implications-for-human-ischemic-cardiomyopathy
#5
Bo Zhang, Tatiana Novitskaya, Debra G Wheeler, Zhaobin Xu, Elena Chepurko, Ryan Huttinger, Heng He, Saradhadevi Varadharaj, Jay L Zweier, Yanna Song, Meng Xu, Frank E Harrell, Yan Ru Su, Tarek Absi, Mark J Kohr, Mark T Ziolo, Dan M Roden, Christian M Shaffer, Cristi L Galindo, Quinn S Wells, Richard J Gumina
BACKGROUND: Despite increased secondary cardiovascular events in patients with ischemic cardiomyopathy (ICM), the expression of innate cardiac protective molecules in the hearts of patients with ICM is incompletely characterized. Therefore, we used a nonbiased RNAseq approach to determine whether differences in cardiac protective molecules occur with ICM. METHODS AND RESULTS: RNAseq analysis of human control and ICM left ventricular samples demonstrated a significant decrease in KCNJ11 expression with ICM...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28193718/h-ras-isoform-mediates-protection-against-pressure-overload-induced-cardiac-dysfunction-in-part-through-activation-of-akt
#6
Takahisa Matsuda, Jae Im Jeong, Shohei Ikeda, Takanobu Yamamoto, Shumin Gao, Gopal J Babu, Peiyong Zhai, Dominic P Del Re
BACKGROUND: In general, Ras proteins are thought to promote cardiac hypertrophy, an important risk factor for cardiovascular disease and heart failure. However, the contribution of different Ras isoforms has not been investigated. The objective of this study was to define the role of H- and K-Ras in modulating stress-induced myocardial hypertrophy and failure. METHODS AND RESULTS: We used H- and K-Ras gene knockout mice and subjected them to pressure overload to induce cardiac hypertrophy and dysfunction...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28193717/differences-in-presentation-and-outcomes-between-children-with-familial-dilated-cardiomyopathy-and-children-with-idiopathic-dilated-cardiomyopathy-a-report-from-the-pediatric-cardiomyopathy-registry-study-group
#7
Paolo Rusconi, James D Wilkinson, Lynn A Sleeper, Minmin Lu, Gerald F Cox, Jeffrey A Towbin, Steven D Colan, Steven A Webber, Charles E Canter, Stephanie M Ware, Daphne T Hsu, Wendy K Chung, John L Jefferies, Christina Cordero, Steven E Lipshultz
BACKGROUND: Research comparing the survival of children with familial dilated cardiomyopathy (FDCM) to that of children with idiopathic dilated cardiomyopathy (IDCM) has produced conflicting results. METHODS AND RESULTS: We analyzed data from children with FDCM or IDCM using the National Heart, Lung, and Blood Institute-funded Pediatric Cardiomyopathy Registry. Compared to children with IDCM (n=647), children with FDCM (n=223) were older (mean 6.2 versus 4.5 years, P<0...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28188269/ventricular-thrombosis-post-venoarterial-extracorporeal-membrane-oxygenation
#8
Mosaad Alhussein, Yasbanoo Moayedi, Juan Duero Posada, Heather Ross, Edward Hickey, Vivek Rao, Filio Billia
No abstract text is available yet for this article.
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28188268/design-and-rationale-of-a-randomized-trial-of-a-care-transition-strategy-in-patients-with-acute-heart-failure-discharged-from-the-emergency-department-guided-hf-get-with-the-guidelines-in-emergency-department-patients-with-heart-failure
#9
Gregory J Fermann, Phillip D Levy, Peter Pang, Javed Butler, S Imran Ayaz, Douglas Char, Patrick Dunn, Cathy A Jenkins, Christy Kampe, Yosef Khan, Vijaya A Kumar, JoAnn Lindenfeld, Dandan Liu, Karen Miller, W Frank Peacock, Samaa Rizk, Chad Robichaux, Russell L Rothman, Jon Schrock, Adam Singer, Sarah A Sterling, Alan B Storrow, Cheryl Walsh, John Wilburn, Sean P Collins
: GUIDED-HF (Get With the Guidelines in Emergency Department Patients With Heart Failure) is a multicenter randomized trial of a patient-centered transitional care intervention in patients with acute heart failure (AHF) who are discharged either directly from the emergency department (ED) or after a brief period of ED-based observation. To optimize care and reduce ED and hospital revisits, there has been significant emphasis on improving transitions at the time of hospital discharge for patients with HF...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28174160/novel-dominant-negative-mutation-in-cardiac-troponin-i-causes-severe-restrictive-cardiomyopathy
#10
Saumya Shah, Haran Yogasundaram, Ratnadeep Basu, Faqi Wang, David I Paterson, Tero-Pekka Alastalo, Gavin Y Oudit
No abstract text is available yet for this article.
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28159826/aortic-waveform-analysis-to-individualize-treatment-in-heart-failure
#11
Peter Wohlfahrt, Vojtech Melenovsky, Margaret M Redfield, Thomas P Olson, Grace Lin, Sahar S Abdelmoneim, Bernhard Hametner, Siegfried Wassertheurer, Barry A Borlaug
BACKGROUND: Afterload reduction is a cornerstone in the management of patients with heart failure (HF) and reduced ejection fraction. However, arterial load and the effect of HF therapies on afterload might vary between individuals. Tailoring vasoactive medicines to patients with HF based upon better understanding of arterial afterload may enable better individualization of therapy. METHODS AND RESULTS: Subjects with HF and reduced ejection fraction underwent aggressive titration of vasoactive HF therapies with assessment of central aortic waveforms analyzed using pulse wave, wave separation, and arterial reservoir models...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28159825/serum-chloride-and-sodium-interplay-in-patients-with-acute-myocardial-infarction-and-heart-failure-with-reduced-ejection-fraction-an-analysis-from-the-high-risk-myocardial-infarction-database-initiative
#12
João Pedro Ferreira, Nicolas Girerd, Kevin Duarte, Stefano Coiro, John J V McMurray, Henry J Dargie, Bertram Pitt, Kenneth Dickstein, Jeffrey M Testani, Faiez Zannad, Patrick Rossignol
BACKGROUND: Serum chloride levels were recently found to be independently associated with mortality in heart failure (HF). METHODS AND RESULTS: We investigated the relationship between serum chloride and clinical outcomes in 7195 subjects with acute myocardial infarction complicated by reduced left ventricular function and HF. The studied outcomes were all-cause mortality, cardiovascular mortality, and hospitalization for HF. Both chloride and sodium had a nonlinear association with the studied outcomes (P<0...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28130379/impact-of-ultrafiltration-on-serum-sodium-homeostasis-and-its-clinical-implication-in-patients-with-acute-heart-failure-congestion-and-worsening-renal-function
#13
Takeshi Kitai, Justin L Grodin, Yong-Hyun Kim, W H Wilson Tang
BACKGROUND: The relationship between changes in serum sodium with clinical events in acute heart failure patients using different decongestive events has not been investigated. This study aimed to describe changes in serum sodium levels during decongestion therapy in patients receiving stepped pharmacological therapy versus ultrafiltration. METHODS AND RESULTS: We studied 188 patients who were enrolled in the CARRESS-HF trial (Cardiorenal Rescue Study in Acute Decompensated Heart Failure)...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28087689/rethinking-revascularization-in-left-ventricular-systolic-dysfunction
#14
EDITORIAL
Adam D DeVore, Eric J Velazquez
No abstract text is available yet for this article.
January 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28087688/thirty-years-of-evidence-on-the-efficacy-of-drug-treatments-for-chronic-heart-failure-with-reduced-ejection-fraction-a-network-meta-analysis
#15
Heather Burnett, Amy Earley, Adriaan A Voors, Michele Senni, John J V McMurray, Celine Deschaseaux, Shannon Cope
BACKGROUND: Treatments that reduce mortality and morbidity in patients with heart failure with reduced ejection fraction, including angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), β-blockers (BB), mineralocorticoid receptor antagonists (MRA), and angiotensin receptor-neprilysin inhibitors (ARNI), have not been studied in a head-to-head fashion. This network meta-analysis aimed to compare the efficacy of these drugs and their combinations regarding all-cause mortality in patients with heart failure with reduced ejection fraction...
January 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28087687/survival-benefits-of-invasive-versus-conservative-strategies-in-heart-failure-in-patients-with-reduced-ejection-fraction-and-coronary-artery-disease-a-meta-analysis
#16
Georg Wolff, Dimitrios Dimitroulis, Felicita Andreotti, Michalina Kołodziejczak, Christian Jung, Pietro Scicchitano, Fiorella Devito, Annapaola Zito, Michele Occhipinti, Battistina Castiglioni, Giuseppe Calveri, Francesco Maisano, Marco M Ciccone, Stefano De Servi, Eliano P Navarese
BACKGROUND: Heart failure with reduced ejection fraction caused by ischemic heart disease is associated with increased morbidity and mortality. It remains unclear whether revascularization by either coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) carries benefits or risks in this group of stable patients compared with medical treatment. METHODS AND RESULTS: We performed a meta-analysis of available studies comparing different methods of revascularization (PCI or CABG) against each other or medical treatment in patients with coronary artery disease and left ventricular ejection fraction ≤40%...
January 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28077429/composite-end-points-in-clinical-trials-of-heart-failure-therapy-how-do-we-measure-the-effect-size
#17
Paul M Brown, Justin A Ezekowitz
Composite end points are popular outcomes in clinical trials of heart failure therapies. For example, a global rank composite is typically analyzed using a Mann-Whitney U test, and the results are summarized by the mean of ranks and a corresponding P value. The mean of ranks is uninformative, and a clinically meaningful estimate of the treatment effect is needed to communicate study results and facilitate an assessment of heterogeneity (the consistency of the effect across outcomes). The probability index is intuitive for clinicians, easy to calculate, and may be applied to various composites...
January 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28069686/inoperable-primary-ovarian-carcinoid-led-to-the-progression-of-carcinoid-heart-disease-from-right-sided-to-both-sided-involvement
#18
Tomonori Tadokoro, Shunsuke Katsuki, Koji Ito, Ken Onitsuka, Atsuhiro Nakashima, Takakazu Sasaguri, Kenji Miyata, Hideo Yamamoto, Masahiro Mohri
No abstract text is available yet for this article.
January 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28069685/associations-of-body-mass-index-with-laboratory-and-biomarkers-in-patients-with-acute-heart-failure
#19
Koen W Streng, Jozine M Ter Maaten, John G Cleland, Christopher M O'Connor, Beth A Davison, Marco Metra, Michael M Givertz, John R Teerlink, Piotr Ponikowski, Daniel M Bloomfield, Howard C Dittrich, Hans L Hillege, Dirk J van Veldhuisen, Adriaan A Voors, Peter van der Meer
BACKGROUND: Plasma concentrations of natriuretic peptides decline with obesity in patients with heart failure. Whether this is true for other biomarkers is unknown. We investigated a wide range of biomarker profiles in acute heart failure across the body mass index (BMI) spectrum. METHODS AND RESULTS: A total of 48 biomarkers, assessing multiple pathophysiological pathways, were measured in 2033 patients included in PROTECT (Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function), a trial comparing the effects of rolofylline to placebo in patients with acute heart failure...
January 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28062539/tissue-expander-as-a-routine-component-of-50cc-total-artificial-heart-implantation-for-bridge-to-transplant
#20
Ryan Avery, Samata R Paidy, Roy Keller, Scott Lick, Richard G Smith, Zain Khalpey
No abstract text is available yet for this article.
January 2017: Circulation. Heart Failure
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