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Circulation. Heart Failure

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https://www.readbyqxmd.com/read/30002116/regulation-of-fluid-volume-from-the-outside-a-role-of-glycosaminoglycans-in-the-skin-interstitium
#1
EDITORIAL
Helge Wiig
No abstract text is available yet for this article.
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30002115/the-luck-of-having-a-cardiac-implantable-electronic-device
#2
EDITORIAL
Maria Rosa Costanzo
No abstract text is available yet for this article.
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30002114/dermal-interstitial-alterations-in-patients-with-heart-failure-and-reduced-ejection-fraction-a-potential-contributor-to-fluid-accumulation
#3
Petra Nijst, Mikhail Olinevich, Petra Hilkens, Pieter Martens, Matthias Dupont, W H Wilson Tang, Ivo Lambrichts, Jean-Paul Noben, Wilfried Mullens
BACKGROUND: Large networks of interstitial glycosaminoglycans help to regulate water and electrolyte homeostasis. The relation between dermal interstitial alterations and occurrence of edema in heart failure patients with reduced ejection fraction (HFrEF) is unknown. We hypothesize that in HFrEF patients (1) interstitial glycosaminoglycan density is increased, (2) changes in the interstitial glycosaminoglycan network are associated with interstitial fluid accumulation, and (3) there is a link between the interstitial glycosaminoglycan network and the renin-angiotensin-aldosterone system...
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/30002113/heartlogic-multisensor-algorithm-identifies-patients-during-periods-of-significantly-increased-risk-of-heart-failure-events-results-from-the-multisense-study
#4
Roy S Gardner, Jagmeet P Singh, Branislav Stancak, Devi G Nair, Michael Cao, Christopher Schulze, Pramodsingh H Thakur, Qi An, Scott Wehrenberg, Eric F Hammill, Yi Zhang, John P Boehmer
BACKGROUND: Care of heart failure (HF) patients results in a high burden on healthcare resources, and estimating prognosis is becoming increasingly important to triage resources wisely. Natriuretic peptides are recommended prognosticators in chronic HF. Our objective was to evaluate whether a multisensor HF index and alert algorithm (HeartLogic) replaces or augments current HF risk stratification. METHODS AND RESULTS: MultiSENSE (Multisensor Chronic Evaluation in Ambulatory Heart Failure Patients) enrolled 900 patients with cardiac resynchronization therapy defibrillators enabled for collection of heart sounds, respiration, thoracic impedance, heart rate, and activity data...
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29997241/embracing-the-long-road-to-precision-medicine
#5
EDITORIAL
Julio A Chirinos, David E Lanfear
No abstract text is available yet for this article.
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29997240/data-driven-approach-to-identify-subgroups-of-heart-failure-with-reduced-ejection-fraction-patients-with-different-prognoses-and-aldosterone-antagonist-response-patterns
#6
João Pedro Ferreira, Kevin Duarte, John J V McMurray, Bertram Pitt, Dirk J van Veldhuisen, John Vincent, Tariq Ahmad, Jasper Tromp, Patrick Rossignol, Faiez Zannad
BACKGROUND: Patients with heart failure with reduced ejection fraction have a poor prognosis. The identification of subgroups with different outcomes and treatment response patterns may help to tailor strategies to each individual patient. We present an exploratory study of patients enrolled in the EMPHASIS-HF trial (Eplerenone in Patients With Systolic Heart Failure and Mild Symptoms) using latent class analysis with validation using the EPHESUS trial (Eplerenone, a Selective Aldosterone Blocker, in Patients With Left Ventricular Dysfunction After Myocardial Infarction) to identify subgroups of patients with different prognosis and response to eplerenone therapy...
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29991489/anthracycline-cardiomyopathy-the-plot-gets-thinner
#7
EDITORIAL
Amanda J Favreau-Lessard, Douglas B Sawyer, Sanjeev A Francis
No abstract text is available yet for this article.
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29991488/left-ventricular-mass-change-after-anthracycline-chemotherapy
#8
Jennifer H Jordan, Sharon M Castellino, Giselle C Meléndez, Heidi D Klepin, Leslie R Ellis, Zanetta Lamar, Sujethra Vasu, Dalane W Kitzman, William O Ntim, Peter H Brubaker, Nathaniel Reichek, Ralph B D'Agostino, W Gregory Hundley
BACKGROUND: Myocardial atrophy and left ventricular (LV) mass reductions are associated with fatigue and exercise intolerance. The relationships between the receipt of anthracycline-based chemotherapy (Anth-bC) and changes in LV mass and heart failure (HF) symptomatology are unknown, as is their relationship to LV ejection fraction (LVEF), a widely used measurement performed in surveillance strategies designed to avert symptomatic HF associated with cancer treatment. METHODS AND RESULTS: We performed blinded, serial assessments of body weight, LVEF and mass, LV-arterial coupling, aortic stiffness, and Minnesota Living with Heart Failure Questionnaire measures before and 6 months after initiating Anth-bC (n=61) and non-Anth-bC (n=15), and in 24 cancer-free controls using paired t and χ2 tests and multivariable linear models...
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29980596/cardiac-shock-revealing-systemic-lupus-erythematosus
#9
Kevin Bouiller, Pauline Naudion, Sébastien Humbert, Helder Gil, Nadine Meaux-Ruault, Maxime Cravat, Lucie Revel, Chloé Molimard, Marie-France Seronde, Nadine Magy-Bertrand
No abstract text is available yet for this article.
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29980595/baseline-characteristics-of-patients-with-heart-failure-and-preserved-ejection-fraction-in-the-paragon-hf-trial
#10
Scott D Solomon, Adel R Rizkala, Martin P Lefkowitz, Victor C Shi, JianJian Gong, Nagesh Anavekar, Stefan D Anker, Juan L Arango, Jose L Arenas, Dan Atar, Turia Ben-Gal, Sergey A Boytsov, Chen-Huan Chen, Vijay K Chopra, John Cleland, Josep Comin-Colet, Hans-Dirk Duengen, Luis E Echeverría Correa, Gerasimos Filippatos, Andreas J Flammer, Michel Galinier, Armando Godoy, Eva Goncalvesova, Stefan Janssens, Tzvetana Katova, Lars Køber, Małgorzata Lelonek, Gerard Linssen, Lars H Lund, Eileen O'Meara, Béla Merkely, Davor Milicic, Byung-Hee Oh, Sergio V Perrone, Naresh Ranjith, Yoshihiko Saito, Jose F Saraiva, Sanjiv Shah, Petar M Seferovic, Michele Senni, Antonio S Sibulo, David Sim, Nancy K Sweitzer, Jyrki Taurio, Dragos Vinereanu, Bojan Vrtovec, Jiří Widimský, Mehmet B Yilmaz, Jingmin Zhou, Robert Zweiker, Inder S Anand, Junbo Ge, Carolyn S P Lam, Aldo P Maggioni, Felipe Martinez, Milton Packer, Marc A Pfeffer, Burkert Pieske, Margaret M Redfield, Jean L Rouleau, Dirk J Van Veldhuisen, Faiez Zannad, Michael R Zile, John J V McMurray
BACKGROUND: To describe the baseline characteristics of patients with heart failure and preserved left ventricular ejection fraction enrolled in the PARAGON-HF trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin Receptor Blocker Global Outcomes in HFpEF) comparing sacubitril/valsartan to valsartan in reducing morbidity and mortality. METHODS AND RESULTS: We report key demographic, clinical, and laboratory findings, and baseline therapies, of 4822 patients randomized in PARAGON-HF, grouped by factors that influence criteria for study inclusion...
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29980594/sarcomeric-auto-oscillations-in-single-myofibrils-from-the-heart-of-patients-with-dilated-cardiomyopathy
#11
Tatsuya Kagemoto, Kotaro Oyama, Mitsunori Yamane, Seiichi Tsukamoto, Fuyu Kobirumaki-Shimozawa, Amy Li, Cristobal Dos Remedios, Norio Fukuda, Shin'ichi Ishiwata
BACKGROUND: Left ventricular wall motion is depressed in patients with dilated cardiomyopathy (DCM). However, whether or not the depressed left ventricular wall motion is caused by impairment of sarcomere dynamics remains to be fully clarified. METHODS AND RESULTS: We analyzed the mechanical properties of single sarcomere dynamics during sarcomeric auto-oscillations (calcium spontaneous oscillatory contractions [Ca-SPOC]) that occurred at partial activation under the isometric condition in myofibrils from donor hearts and from patients with severe DCM (New York Heart Association classification III-IV)...
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29921704/unmasking-early-wild-type-transthyretin-amyloidosis-cardiomyopathy-in-a-patient-with-refractory-atrial-fibrillation-and-unremarkable-cardiac-imaging
#12
Danny Varedi, Tibor Kovacsovics, Erinn Downs Kelly, Jo Abraham, Jared Cowley, Kelsey Barrell, Monica P Revelo, Josef Stehlik, Stavros Drakos, Nassir Marrouche, Brent Wilson, Eric A Swanson, James Fang, Jose Nativi-Nicolau
No abstract text is available yet for this article.
July 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29903893/living-without-a-pulse-the-vascular-implications-of-continuous-flow-left-ventricular-assist-devices
#13
Suneet N Purohit, William K Cornwell, Jay D Pal, JoAnn Lindenfeld, Amrut V Ambardekar
Pulsatility seems to have a teleological role because evolutionary hierarchy favors higher ordered animals with more complex, multichamber circulatory systems that generate higher pulse pressure compared with lower ordered animals. Yet despite years of such natural selection, the modern generation of continuous-flow left ventricular assist devices (CF-LVADs) that have been increasingly used for the last decade have created a unique physiology characterized by a nonpulsatile, nonlaminar blood flow profile with the absence of the usual large elastic artery Windkessel effect during diastole...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29891739/predicting-the-future-of-cardiac-allograft-vasculopathy-with-cardiac-positron-emission-tomography-ready-for-prime-time
#14
EDITORIAL
Eugene C DePasquale
No abstract text is available yet for this article.
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29891738/expression-and-implication-of-clusterin-in-left-ventricular-remodeling-after-myocardial-infarction
#15
Annie Turkieh, Marie Fertin, Marion Bouvet, Paul Mulder, Hervé Drobecq, Gilles Lemesle, Nicolas Lamblin, Pascal de Groote, Sina Porouchani, Maggy Chwastyniak, Olivia Beseme, Philippe Amouyel, Frédéric Mouquet, Jean-Luc Balligand, Vincent Richard, Christophe Bauters, Florence Pinet
BACKGROUND: Left ventricular remodeling (LVR) after myocardial infarction is associated with an increased risk of heart failure and death. In spite of a modern therapeutic approach, LVR remains relatively frequent and difficult to predict in clinical practice. Our aim was to identify new biomarkers of LVR and understand their involvement in its development. METHODS AND RESULTS: Proteomic analysis of plasma from the REVE-2 study (Remodelage Ventriculaire)-a study dedicated to the analysis of LVR which included 246 patients after a first anterior myocardial infarction-identified increased plasma levels of CLU (clusterin) in patients with high LVR...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29891737/reduced-myocardial-flow-reserve-by-positron-emission-tomography-predicts-cardiovascular-events-after-cardiac-transplantation
#16
Matthew C Konerman, John J Lazarus, Richard L Weinberg, Ravi V Shah, Michael Ghannam, Scott L Hummel, James R Corbett, Edward P Ficaro, Keith D Aaronson, Monica M Colvin, Todd M Koelling, Venkatesh L Murthy
BACKGROUND: We evaluated the diagnostic and prognostic value of quantification of myocardial flow reserve (MFR) with positron emission tomography (PET) in orthotopic heart transplant patients. METHODS AND RESULTS: We retrospectively identified orthotopic heart transplant patients who underwent rubidium-82 cardiac PET imaging. The primary outcome was the composite of cardiovascular death, acute coronary syndrome, coronary revascularization, and heart failure hospitalization...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29853478/sex-differences-at-the-time-of-myectomy-in-hypertrophic-cardiomyopathy
#17
Louise L A M Nijenkamp, Ilse A E Bollen, Hannah G van Velzen, Jessica A Regan, Marjon van Slegtenhorst, Hans W M Niessen, Arend F L Schinkel, Martina Krüger, Corrado Poggesi, Carolyn Y Ho, Diederik W D Kuster, Michelle Michels, Jolanda van der Velden
BACKGROUND: One of the first clinically detectable alterations in heart function in hypertrophic cardiomyopathy (HCM) is a decline in diastolic function. Diastolic dysfunction is caused by changes in intrinsic properties of cardiomyocytes or an increase in fibrosis. We investigated whether clinical and cellular parameters of diastolic function are different between male and female patients with HCM at the time of myectomy. METHODS AND RESULTS: Cardiac tissue from the interventricular septum of patients with HCM (27 women and 44 men) was obtained during myectomy preceded by echocardiography...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29848515/eosinophilic-myocarditis-with-rapid-progression-to-cardiogenic-shock-managed-with-mechanical-support-and-high-dose-corticosteroids
#18
Samvit Tandan, Seth N Meltzer, Carlos D Davila, Marvin A Konstam, Martin M LeWinter
No abstract text is available yet for this article.
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29844244/intake-of-different-dietary-proteins-and-risk-of-heart-failure-in-men-the-kuopio-ischaemic-heart-disease-risk-factor-study
#19
Heli E K Virtanen, Sari Voutilainen, Timo T Koskinen, Jaakko Mursu, Tomi-Pekka Tuomainen, Jyrki K Virtanen
BACKGROUND: Animal and plant protein intakes have indicated opposite associations with cardiovascular mortality risk. Whether dietary proteins are associated with risk of heart failure (HF) is unclear. Thus, we examined the associations of proteins from different food sources with risk of HF. METHODS AND RESULTS: The study included 2441 men aged 42 to 60 years at the baseline examinations in 1984 to 1989 in the Kuopio Ischaemic Heart Disease Risk Factor Study. Protein intakes at baseline were assessed with 4-day dietary records...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29793934/trends-in-noncardiovascular-comorbidities-among-patients-hospitalized-for-heart-failure-insights-from-the-get-with-the-guidelines-heart-failure-registry
#20
Abhinav Sharma, Xin Zhao, Bradley G Hammill, Adrian F Hernandez, Gregg C Fonarow, G Michael Felker, Clyde W Yancy, Paul A Heidenreich, Justin A Ezekowitz, Adam D DeVore
BACKGROUND: The increase in medical complexity among patients hospitalized with heart failure (HF) may be reflected by an increase in concomitant noncardiovascular comorbidities. Among patients hospitalized with HF, the temporal trends in the prevalence of noncardiovascular comorbidities have not been well described. METHODS AND RESULTS: We used data from 207 984 patients in the Get With The Guidelines-Heart Failure registry (from 2005 to 2014) to evaluate the prevalence and trends of noncardiovascular comorbidities (chronic obstructive pulmonary disorder/asthma, anemia, diabetes mellitus, obesity [body mass index ≥30 kg/m2 ], and renal impairment) among patients hospitalized with HF...
June 2018: Circulation. Heart Failure
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