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Oxidative Medicine and Cellular Longevity

Marcela Silva Dos Santos, Juliana da Silva, Ana Paula Simões Menezes, Francisco Maikon Corrêa de Barros, Maria Luisa Brodt Lemes, Raíssa R Rossatto, Cleverson Feistel, Indara Dedigo de Almeida, Ivana Grivicich, Lismare Prado, Jaqueline Nascimento Picada, Alexandre de Barros Falcão Ferraz
The use in folk medicine of Baccharis trimera and recent studies on DNA damage by oxidative stress mechanisms have motivated this study. We investigated the biotoxicological effects of trimeroside from this plant. Aqueous extract from aerial parts of B. trimera was fractioned by flash chromatography for further isolation by thin-layer chromatography. The novel nor-monoterpene glycoside, trimeroside, and three flavonoids, cirsimaritin, luteolin and quercetin, were isolated. The genotoxic and mutagenic potential of trimeroside was determined by Salmonella /microsome (TA98 and TA100), comet assay, and cytokinesis-block micronucleus cytome assay (CBMN-cyt) in HepG2 cells...
2018: Oxidative Medicine and Cellular Longevity
Dinender K Singla, Jing Wang
[This corrects the article DOI: 10.1155/2016/5810908.].
2018: Oxidative Medicine and Cellular Longevity
Yun Xue, Ting Guo, Lifang Zou, Yingxin Gong, Bing Wu, Zhihua Yi, Tianyu Jia, Shanhong Zhao, Liran Shi, Lin Li, Huilong Yuan, Hui Liu, Yun Gao, Guilin Li, Shuangmei Liu, Hong Xu, Chunping Zhang, Shangdong Liang, Guodong Li
Insulin resistance and type 2 diabetes mellitus (T2DM) are highly prevalent around the world. Elevated concentrations of free fatty acids (FFAs) are closely related to insulin resistance and T2DM. P2X7 receptor is an ion channel gated by ATP, which is implicated in various scenarios including immune response, pain, and inflammation. In this study, we have explored whether P2X7 receptor is involved in pathological changes in human umbilical vein endothelial cells (HUVECs) induced by high FFA treatment, and the potential beneficial effects of evodiamine...
2018: Oxidative Medicine and Cellular Longevity
Li Tao, Min Xu, Xiaojun Dai, Tengyang Ni, Dan Li, Feng Jin, Haibo Wang, Lide Tao, Bo Pan, James R Woodgett, Yayun Qian, Yanqing Liu
Danshen, the dried root of Salvia miltiorrhiza , one of the most investigated medicinal plants with well-defined phytochemical constituents, has shown prominent clinical outcomes for antioxidant, anti-inflammatory, and anticoagulant activities to attain vascular protection and additional benefits for cancer therapy. More recently, activation of neutrophil and excessive formation of neutrophil extracellular traps (NETs) have been observed in pathological conditions of metastatic cancers; thus, we hypothesized that suppression of NETs could account for an essential cellular event underlying Danshen-mediated reduction of the incidence of metastasis...
2018: Oxidative Medicine and Cellular Longevity
Yazhou Lin, Guoqing Tang, Yucheng Jiao, Ye Yuan, Yuehuan Zheng, Yong Chen, Jiaqi Xiao, Changwei Li, Zhe Chen, Peng Cao
Accumulating evidence suggests that Propionibacterium acnes ( P. acnes ) is a novel pathogenic factor promoting intervertebral disc degeneration (IVDD). However, the underlying mechanisms by which P. acnes induces IVDD have been unclear. In this study, we quantified the severity of IVDD, as well as the expressions of inducible nitric oxide synthase (iNOS)/nitric oxide (NO) and cyclooxygenase (COX-2)/prostaglandin (PGE2 ) in human intervertebral discs (IVDs) infected with P. acnes . Compared with P. acnes -negative IVDs, P...
2018: Oxidative Medicine and Cellular Longevity
Piotr Rola, Adrian Doroszko, Ewa Szahidewicz-Krupska, Paweł Rola, Piotr Dobrowolski, Robert Skomro, Alicja Szymczyszyn, Grzegorz Mazur, Arkadiusz Derkacz
[This corrects the article DOI: 10.1155/2017/6201797.].
2018: Oxidative Medicine and Cellular Longevity
Yihui Xiao, Ming He, Xiao Liang, Jianqing She, Lan He, Yan Liu, Juan Zou, Zuyi Yuan
We explored whether pu-erh tea consumption ameliorates atherosclerosis and the possible mechanism for its effects in apolipoprotein E-deficient (ApoE-/- ) mice. Our data showed that pu-erh tea consumption markedly reduced early fatty streak formation and the advanced fibrofatty plaque sizes. Additionally, the mean proportion of inflammatory macrophages in the plaque decreased, and the number of apoptotic macrophages increased significantly. NF- κ B activity in peritoneal macrophages decreased by 75.6% compared to the controls, similar with the levels of IL-6, IL-12, and TNF- α expression...
2018: Oxidative Medicine and Cellular Longevity
Anacharis B Sá-Nakanishi, Jamil Soni-Neto, Lucas S Moreira, Geferson A Gonçalves, Francielli M S Silva, Lívia Bracht, Ciomar A Bersani-Amado, Rosane M Peralta, Adelar Bracht, Jurandir F Comar
Methyl jasmonate (MeJA) is a fatty acid-derived cyclopentanone which shares structural similarities with prostaglandins and has been under study as a promising anti-inflammatory agent. This study investigated the actions of MeJA on systemic inflammation and oxidative status in rats with adjuvant-induced arthritis, a model for rheumatoid arthritis. MeJA (75 to 300 mg·kg-1 ) was administrated orally during 18 days after arthritis induction with Freund's adjuvant. Articular and systemic inflammation was greatly increased in arthritic rats, likewise the oxidative stress in plasma and liver...
2018: Oxidative Medicine and Cellular Longevity
Eszter M Horváth, Rita Magenheim, Nóra J Béres, Rita Benkő, Tamás Pék, Ádám G Tabák, Csaba Szabo
Background: Oxidative-nitrative stress and poly (ADP-ribose) polymerase activation have been previously observed in healthy and gestational diabetic pregnancies, and they were also linked to the development of metabolic diseases. The aim of the present study was to examine these parameters and their correlation to known metabolic risk factors following healthy and gestational diabetic pregnancies. Methods: Fasting and 2 h postload plasma total peroxide level, protein tyrosine nitration, and poly (ADP-ribose) polymerase activation were measured in circulating leukocytes three years after delivery in women following healthy, "mild" (diet-treated) or "severe" (insulin-treated) gestational diabetic pregnancy during a standard 75 g OGTT...
2018: Oxidative Medicine and Cellular Longevity
Kota V Ramana, Aramati B M Reddy, N V Ravi Kumar Majeti, Sharad S Singhal
No abstract text is available yet for this article.
2018: Oxidative Medicine and Cellular Longevity
Dehua Liao, Daxiong Xiang, Ruili Dang, Pengfei Xu, Jiemin Wang, Wenxiu Han, Yingzhou Fu, Dunwu Yao, Lizhi Cao, Pei Jiang
Doxorubicin (DOX) is a broad-spectrum antitumor drug while its use is limited due to its neurobiological side effects associated with depression. We investigated the neuroprotective efficacy of dl-3-n-butylphthalide (dl-NBP) against DOX-induced anxiety- and depression-like behaviors in rats. dl-NBP was given (30 mg/kg) daily by gavage over three weeks starting seven days before DOX administration. Elevated plus maze (EPM) test, forced swimming test (FST), and sucrose preference test (SPT) were performed to assess anxiety- and depression-like behaviors...
2018: Oxidative Medicine and Cellular Longevity
Ewelina Barcińska, Justyna Wierzbicka, Agata Zauszkiewicz-Pawlak, Dagmara Jacewicz, Aleksandra Dabrowska, Iwona Inkielewicz-Stepniak
Pancreatic ductal adenocarcinoma is one of the most aggressive human malignancies, where the 5-year survival rate is less than 4% worldwide. Successful treatment of pancreatic cancer is a challenge for today's oncology. Several studies showed that increased levels of oxidative stress may cause cancer cells damage and death. Therefore, we hypothesized that oxidative as well as nitro-oxidative stress is one of the mechanisms inducing pancreatic cancer programmed cell death. We decided to use silver nanoparticles (AgNPs) (2...
2018: Oxidative Medicine and Cellular Longevity
Xue Jiang, Shanshan Teng, Xue Wang, Shan Li, Yaqin Zhang, Di Wang
Tuber melanosporum (TM), a valuable edible fungus, contains 19 types of fatty acid, 17 types of amino acid, 6 vitamins, and 7 minerals. The antidiabetic and antinephritic effects of TM and the underlying mechanisms related to oxidative stress were investigated in db/db mice. Eight-week oral administration of metformin (Met) at 0.1 g/kg and TM at doses of 0.2 and 0.4 g/kg decreased body weight, plasma glucose, serum levels of glycated hemoglobin, triglyceride, and total cholesterol and increased serum levels of high-density lipoprotein cholesterol in the mice, suggesting hypoglycemic and hypolipidemic effects...
2018: Oxidative Medicine and Cellular Longevity
Zahra Sayyar, Alireza Yazdinezhad, Maryam Hassan, Iraj Jafari Anarkooli
Formaldehyde, as a frequently used compound in many applications, crosses the blood-brain barrier and leads to hippocampal cell death and memory impairment. This study investigates the effects of ethanolic extract of Matricaria chamomilla (MC) on passive avoidance learning induced by damaged hippocampal cells and evaluates the antioxidant traits of MC. The male Wistar rats were divided into six (6 in each) groups: control (10 mg/kg normal saline), 200 (200 mg/kg MC extract), 500 (500 mg/kg MC extract), F (10 mg/kg formaldehyde), F200 (10 mg/kg formaldehyde and 200 mg/kg MC extract), and F500 (10 mg/kg formaldehyde and 500 mg/kg MC extract)...
2018: Oxidative Medicine and Cellular Longevity
Giovanni Tarantino, Carmine Finelli, Franco Scopacasa, Fabrizio Pasanisi, Franco Contaldo, Domenico Capone, Silvia Savastano
[This corrects the article DOI: 10.1155/2014/920676.].
2018: Oxidative Medicine and Cellular Longevity
Alexandra Gyongyosi, Laura Terraneo, Paola Bianciardi, Arpad Tosaki, Istvan Lekli, Michele Samaja
The redox imbalance and the consequent oxidative stress have been implicated in many pathological conditions, including cardiovascular diseases. The lack or the excess of O2 supply can alter the redox balance. The aim of the present study was to understand the heart responses to prolonged hypoxia or hyperoxia and how such situations may activate survival mechanisms or trigger cell death. Seven-week-old Foxn1 mice were exposed to hypoxia (10% O2 ), normoxia (21% O2 ), or hyperoxia (30% O2 ) for 28 days, then the heart tissue was excised and analyzed...
2018: Oxidative Medicine and Cellular Longevity
Jiachang Hu, Yimei Wang, Shuan Zhao, Jing Chen, Shi Jin, Ping Jia, Xiaoqiang Ding
Remote ischemic preconditioning (RIPC) is an adaptive response, manifesting when local short-term ischemic preconditioning reduces damage to adjacent or distant tissues or organs. O-linked β -N-acetylglucosamine (O-GlcNAc) glycosylation of intracellular proteins denotes a type of posttranslational modification that influences multiple cytoplasmic and nuclear protein functions. Growing evidence indicates that stress can induce an acute increase in O-GlcNAc levels, which can be cytoprotective. The current study aimed to determine whether RIPC can provide renoprotection against contrast-induced acute kidney injury (CI-AKI) by augmenting O-GlcNAc signaling...
2018: Oxidative Medicine and Cellular Longevity
Yasutaka Mitamura, Mika Murai, Chikage Mitoma, Masutaka Furue
Systemic fibrosing or sclerotic disorders are life-threatening, but only very limited treatment modalities are available for them. In recent years, periostin (POSTN), a major extracellular matrix component, was established by several studies as a novel key player in the progression of systemic fibrotic disease. In this research, we revealed the involvement of oxidative stress in the expression of POSTN induced by TGF- β 1 and IL-13 in dermal fibroblasts. We found that the antioxidant cinnamaldehyde activated the NRF2/HMOX1 pathway...
2018: Oxidative Medicine and Cellular Longevity
Chiara Mandò, Gaia Maria Anelli, Chiara Novielli, Paola Panina-Bordignon, Maddalena Massari, Martina Ilaria Mazzocco, Irene Cetin
A lipotoxic placental environment is recognized in maternal obesity, with increased inflammation and oxidative stress. These changes might alter mitochondrial function, with excessive production of reactive oxygen species, in a vicious cycle leading to placental dysfunction and impaired pregnancy outcomes. Here, we hypothesize that maternal pregestational body mass index (BMI) and glycemic levels can alter placental mitochondria. We measured mitochondrial DNA (mtDNA, real-time PCR) and morphology (electron microscopy) in placentas of forty-seven singleton pregnancies at elective cesarean section...
2018: Oxidative Medicine and Cellular Longevity
Mayra Alejandra Mendez-Encinas, Elizabeth Carvajal-Millan, Agustín Rascon-Chu, Humberto Francisco Astiazaran-Garcia, Dora Edith Valencia-Rivera
In the last years, biomedical research has focused its efforts in the development of new oral delivery systems for the treatment of different diseases. Ferulated arabinoxylans are polysaccharides from cereals that have been gaining attention in the pharmaceutical field due to their prebiotic, antioxidant, and anticancer properties. The antioxidant and anticancer properties of these polysaccharides make them attractive compounds for the treatment of cancer, particularly colon cancer. In addition, ferulated arabinoxylans can form covalent gels through the cross-linking of their ferulic acids...
2018: Oxidative Medicine and Cellular Longevity
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