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Oxidative Medicine and Cellular Longevity

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https://www.readbyqxmd.com/read/28536646/oxidative-stress-and-inflammation-in-cardiovascular-disease
#1
EDITORIAL
Noemí García, Cecilia Zazueta, Leopoldo Aguilera-Aguirre
No abstract text is available yet for this article.
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28529677/oxidative-stress-in-liver-diseases-pathogenesis-prevention-and-therapeutics
#2
EDITORIAL
Ravirajsinh N Jadeja, Ranjitsinh V Devkar, Srinivas Nammi
No abstract text is available yet for this article.
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28529676/dietary-supplements-antioxidants-impact-on-redox-status-in-brain-diseases
#3
EDITORIAL
Gilles J Guillemin, Musthafa Mohamed Essa, Byoung-Joon Song, Thamilarasan Manivasagam
No abstract text is available yet for this article.
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28512525/h2s-donor-nahs-changes-the-production-of-endogenous-h2s-and-no-in-d-galactose-induced-accelerated-ageing
#4
Wei Wu, Cui-Lan Hou, Xue-Pan Mu, Chen Sun, Yi-Chun Zhu, Ming-Jie Wang, Qian-Zhou Lv
Aims. The study was designed to explore whether hydrogen sulphide (H2S) and nitric oxide (NO) generation changed in D-galactose- (D-gal-) induced ageing, the possible effects of exogenous H2S supplementation, and related mechanisms. Results. In D-gal-induced senescent mice, both H2S and NO levels in the heart, liver, and kidney tissues were decreased significantly. A similar trend was observed in D-gal-challenged human umbilical vein endothelial cells (HUVECs). Sustained H2S donor (NaHS) treatment for 2 months elevated H2S and NO levels in these mice, and during this period, the D-gal-induced senescent phenotype was reversed...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28503253/research-progress-on-signaling-pathway-associated-oxidative-stress-in-endothelial-cells
#5
REVIEW
Ying Liang, Jiajia Li, Qinlu Lin, Ping Huang, Lin Zhang, Wei Wu, Youchu Ma
Studying the mechanisms of oxidative stress in endothelial cells is vital to the discovery of novel drugs for the treatment of cardiovascular disease. This article reviews the progress within the field of the role of oxidative responses in the physiology and growth of endothelial cells and emphasizes the effects of several main signal pathways involved in the oxidative stress of endothelial cells. Herein, we aim to provide scientific direction that can serve as a basis for researchers specializing in the signaling pathway of oxidative stress...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28491239/opuntia-spp-characterization-and-benefits-in-chronic-diseases
#6
REVIEW
María Del Socorro Santos Díaz, Ana-Paulina Barba de la Rosa, Cécile Héliès-Toussaint, Françoise Guéraud, Anne Nègre-Salvayre
Opuntia species have been used for centuries as food resources and in traditional folk medicine for their nutritional properties and their benefit in chronic diseases, particularly diabetes, obesity, cardiovascular diseases, and cancer. These plants are largely distributed in America, Africa, and the Mediterranean basin. Opuntia spp. have great economic potential because they grow in arid and desert areas, and O. ficus-indica, the domesticated O. species, is used as a nutritional and pharmaceutical agent in various dietary and value-added products...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28491238/inhibition-of-mir-302-suppresses-hypoxia-reoxygenation-induced-h9c2-cardiomyocyte-death-by-regulating-mcl-1-expression
#7
Yao-Ching Fang, Chi-Hsiao Yeh
MicroRNAs play important roles in cell proliferation, differentiation, and apoptosis, and their expression influences cardiomyocyte apoptosis resulting from ischemia-induced myocardial infarction. Here, we determined the role of miR expression in cardiomyocyte apoptosis during hypoxia and reoxygenation. The rat cardiomyocyte cell line H9c2 was incubated for 3 h in normal or hypoxia medium, followed by reoxygenation for 24 h and transfection with a miR-302 mimic or antagomir. The effect of miR-302 on myeloid leukemia cell-differentiation protein-1 (Mcl-1) expression was determined by western blot, real-time polymerase chain reaction, and luciferase reporter assays, with cell viability assays...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28491237/potential-of-lichen-compounds-as-antidiabetic-agents-with-antioxidative-properties-a-review
#8
REVIEW
Vinitha M Thadhani, Veranja Karunaratne
The advancement in the knowledge of potent antioxidants has uncovered the way for greater insight in the treatment of diabetic complications. Lichens are a rich resource of novel bioactive compounds and their antioxidant potential is well documented. Herein we review the antidiabetic potential of lichens which have received considerable attention, in the recent past. We have correlated the antidiabetic and the antioxidant potential of lichen compounds. The study shows a good accordance between antioxidant and antidiabetic activity of lichens and points out the need to look into gathering the scarce and scattered data on biological activities for effective utilization...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28479957/4-hydroxynonenal-contributes-to-angiogenesis-through-a-redox-dependent-sphingolipid-pathway-prevention-by-hydralazine-derivatives
#9
Caroline Camaré, Corinne Vanucci-Bacqué, Nathalie Augé, Mélanie Pucelle, Corinne Bernis, Audrey Swiader, Michel Baltas, Florence Bedos-Belval, Robert Salvayre, Anne Nègre-Salvayre
The neovascularization of atherosclerotic lesions is involved in plaque development and may contribute to intraplaque hemorrhage and plaque fragilization and rupture. Among the various proangiogenic agents involved in the neovascularization process, proatherogenic oxidized LDLs (oxLDLs) contribute to the formation of tubes via the generation of sphingosine 1-phosphate (S1P), a major mitogenic and proangiogenic sphingolipid mediator. In this study, we investigated whether 4-hydroxynonenal (4-HNE), an aldehydic lipid oxidation product abundantly present in oxLDLs, contributes to their proangiogenic properties...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28479956/a-single-zidovudine-azt-administration-delays-hepatic-cell-proliferation-by-altering-oxidative-state-in-the-regenerating-rat-liver
#10
Armando Butanda-Ochoa, Diego Rolando Hernández-Espinosa, Marisela Olguín-Martínez, Lourdes Sánchez-Sevilla, Mario R Rodríguez, Benito Chávez-Rentería, Alberto Aranda-Fraustro, Rolando Hernández-Muñoz
The 3'-azido-3'-deoxythymidine or Zidovudine (AZT) was the first antiretroviral drug used in the treatment of HIV patients, which has good effectiveness but also hepatotoxic side effects that include cell cycle arrest and oxidative/nitrative mitochondrial damage. Whether such an oxidative damage may affect the proliferative-regenerative capacity of liver remains to be clearly specified at doses commonly used in the clinical practice. In this study, we described the oxidative-proliferative effect of AZT administered at a common clinical dose in rat liver submitted to 70% partial hepatectomy (PH)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28473879/dihydropyridine-derivatives-as-cell-growth-modulators-in-vitro
#11
Imanta Bruvere, Egils Bisenieks, Janis Poikans, Janis Uldrikis, Aiva Plotniece, Karlis Pajuste, Martins Rucins, Brigita Vigante, Zenta Kalme, Marina Gosteva, Ilona Domracheva, Astrida Velena, Tea Vukovic, Lidija Milkovic, Gunars Duburs, Neven Zarkovic
The effects of eleven 1,4-dihydropyridine derivatives (DHPs) used alone or together with prooxidant anticancer drug doxorubicin were examined on two cancer (HOS, HeLa) and two nonmalignant cell lines (HMEC, L929). Their effects on the cell growth ((3)H-thymidine incorporation) were compared with their antiradical activities (DPPH assay), using well-known DHP antioxidant diludine as a reference. Thus, tested DHPs belong to three groups: (1) antioxidant diludine; (2) derivatives with pyridinium moieties at position 4 of the 1,4-DHP ring; (3) DHPs containing cationic methylene onium (pyridinium, trialkylammonium) moieties at positions 2 and 6 of the 1,4-DHP ring...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28473878/ho-1-is-essential-for-tetrahydroxystilbene-glucoside-mediated-mitochondrial-biogenesis-and-anti-inflammation-process-in-lps-treated-raw264-7-macrophages
#12
Weihua Yu, Xiaodi Zhang, Hao Wu, Qingbiao Zhou, Zhao Wang, Rui Liu, Jiangzheng Liu, Xin Wang, Chunxu Hai
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG), an important monomer extracted from Polygonum multiflorum, can prevent a number of inflammation associated chronic diseases. However, the mechanism involved in TSG inducing anti-inflammatory role remains unclear. As an inducible antioxidant enzyme, Heme oxygenase-1 (HO-1), is crucial for protecting the mammalian cells against adverse stimuli. Here, we found that the TSG treatment strongly induces the expression of HO-1 in an NRF2-depended manner. Meanwhile, TSG increased the mitochondrial mass through upregulation of the mitochondrial biogenesis activators (PGC-1α, NRF1, and TFAM) as well as the mitochondrial complex IV...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28473877/involvement-of-nrf2-in-ocular-diseases
#13
REVIEW
Shehzad Batliwala, Christy Xavier, Yang Liu, Hongli Wu, Iok-Hou Pang
The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28465762/paricalcitol-pretreatment-attenuates-renal-ischemia-reperfusion-injury-via-prostaglandin-e2-receptor-ep4-pathway
#14
Yu Ah Hong, Keum Jin Yang, So Young Jung, Ki Cheol Park, Hyunsu Choi, Jeong Min Oh, Sang Ju Lee, Yoon Kyung Chang, Cheol Whee Park, Chul Woo Yang, Suk Young Kim, Hyeon Seok Hwang
The protective mechanism of paricalcitol remains unclear in renal ischemia-reperfusion (IR) injury. We investigated the renoprotective effects of paricalcitol in IR injury through the prostaglandin E2 (PGE2) receptor EP4. Paricalcitol was injected into IR-exposed HK-2 cells and mice subjected to bilateral kidney ischemia for 23 min and reperfusion for 24 hr. Paricalcitol prevented IR-induced cell death and EP4 antagonist cotreatment offset these protective effects. Paricalcitol increased phosphorylation of Akt and cyclic AMP responsive element binding protein (CREB) and suppressed nuclear factor-κB (NF-κB) in IR-exposed cells and cotreatment of EP4 antagonist or EP4 small interfering RNA blunted these signals...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28458777/evaluating-the-risk-of-tumors-diseases-based-on-measurement-of-urinary-and-serumal-antioxidants-using-the-new-agar-diffusion-methods
#15
Ying Zhou, Jing Chen, Zhen Wang, Hui Liu
Objectives. To discuss the characteristics of the amount of urinary total antioxidants in tumor diseases and the possibility of utilizing the changing regulation of urinary antioxidants to diagnose tumor diseases. Method. Urine and serum specimens from 130 healthy people were used to investigate the variation of antioxidant capacity against age. Urine and serum specimens from 44 unselected patients with tumors and 44 healthy people with same age background were used to explore the significance of urinary antioxidant capacity in clinic to diagnose tumor diseases...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28458776/role-of-protein-kinase-c-and-nox2-derived-reactive-oxygen-species-formation-in-the-activation-and-maturation-of-dendritic-cells-by-phorbol-ester-and-lipopolysaccharide
#16
Judith Stein, Sebastian Steven, Matthias Bros, Stephan Sudowe, Michael Hausding, Matthias Oelze, Thomas Münzel, Stephan Grabbe, Angelika Reske-Kunz, Andreas Daiber
Aims. Activation/maturation of dendritic cells (DCs) plays a central role in adaptive immune responses by antigen processing and (cross-) activation of T cells. There is ongoing discussion on the role of reactive oxygen species (ROS) in these processes and with the present study we investigated this enigmatic pathway. Methods and Results. DCs were cultured from precursors in the bone marrow of mice (BM-DCs) and analyzed for ROS formation, maturation, and T cell stimulatory capacity upon stimulation with phorbol ester (PDBu) and lipopolysaccharide (LPS)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28424745/distinguishing-the-unique-neuropathological-profile-of-blast-polytrauma
#17
W Brad Hubbard, Shaylen Greenberg, Carly Norris, Joseph Eck, Erin Lavik, Pamela VandeVord
Traumatic brain injury sustained after blast exposure (blast-induced TBI) has recently been documented as a growing issue for military personnel. Incidence of injury to organs such as the lungs has decreased, though current epidemiology still causes a great public health burden. In addition, unprotected civilians sustain primary blast lung injury (PBLI) at alarming rates. Often, mild-to-moderate cases of PBLI are survivable with medical intervention, which creates a growing population of survivors of blast-induced polytrauma (BPT) with symptoms from blast-induced mild TBI (mTBI)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28424744/oxidative-stress-in-retinal-diseases
#18
EDITORIAL
Yuhei Nishimura, Hideaki Hara, Mineo Kondo, Samin Hong, Takeshi Matsugi
No abstract text is available yet for this article.
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28421130/antiretroviral-therapy-initiation-alters-the-redox-system-of-asymptomatic-hiv-infected-individuals-a-longitudinal-study
#19
Karen Ingrid Tasca, Juliana Trindade Caleffi, Camila Renata Correa, Mariana Gatto, Francilene Capel Tavares, Caio Cavassan Camargo, Alexandrina Sartori, Mara Biasin, Lenice do Rosário de Souza
Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters. This is a longitudinal study including 30 asymptomatic patients divided according to their CD4+ T cell count (G1: <500 cell/mL; G2: >500 cell/mL) before (M0) and after (M1) cART initiation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28421129/protective-effects-of-dinitrosyl-iron-complexes-under-oxidative-stress-in-the-heart
#20
Valery I Kapelko, Vladimir L Lakomkin, Alexander A Abramov, Elena V Lukoshkova, Nidas A Undrovinas, Asker Y Khapchaev, Vladimir P Shirinsky
Background. Nitric oxide can successfully compete with oxygen for sites of electron-transport chain in conditions of myocardial hypoxia. These features may prevent excessive oxidative stress occurring in cardiomyocytes during sudden hypoxia-reoxygenation. Aim. To study the action of the potent stable NO donor dinitrosyl iron complex with glutathione (Oxacom®) on the recovery of myocardial contractile function and Ca(2+) transients in cardiomyocytes during hypoxia-reoxygenation. Results. The isolated rat hearts were subjected to 30 min hypoxia followed by 30 min reoxygenation...
2017: Oxidative Medicine and Cellular Longevity
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