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Oxidative Medicine and Cellular Longevity

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https://www.readbyqxmd.com/read/28928906/comparison-of-anti-inflammatory-effects-of-flavonoid-rich-common-and-tartary-buckwheat-sprout-extracts-in-lipopolysaccharide-stimulated-raw-264-7-and-peritoneal-macrophages
#1
Tae Gyu Nam, Tae-Gyu Lim, Bong Han Lee, Sol Lim, Hee Kang, Seok Hyun Eom, Miyoung Yoo, Hae Won Jang, Dae-Ok Kim
Buckwheat sprouts have been widely consumed all around world due to their great abundance of bioactive compounds. In this study, the anti-inflammatory effects of flavonoid-rich common buckwheat sprout (CBS) and tartary buckwheat sprout (TBS) extracts were evaluated in lipopolysaccharide- (LPS-) stimulated RAW 264.7 murine macrophages and primary peritoneal macrophages from male BALB/c mice. Based on the reversed-phase HPLC analysis, the major flavonoids in CBS were determined to be C-glycosylflavones (orientin, isoorientin, vitexin, and isovitexin), quercetin-3-O-robinobioside, and rutin, whereas TBS contained only high amounts of rutin...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28928905/fucoxanthin-a-marine-carotenoid-attenuates-%C3%AE-amyloid-oligomer-induced-neurotoxicity-possibly-via-regulating-the-pi3k-akt-and-the-erk-pathways-in-sh-sy5y-cells
#2
Jiajia Lin, Jie Yu, Jiaying Zhao, Ke Zhang, Jiachen Zheng, Jialing Wang, Chunhui Huang, Jingrong Zhang, Xiaojun Yan, William H Gerwick, Qinwen Wang, Wei Cui, Shan He
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by neurofibrillary tangles, synaptic impairments, and loss of neurons. Oligomers of β-amyloid (Aβ) are widely accepted as the main neurotoxins to induce oxidative stress and neuronal loss in AD. In this study, we discovered that fucoxanthin, a marine carotenoid with antioxidative stress properties, concentration dependently prevented Aβ oligomer-induced increase of neuronal apoptosis and intracellular reactive oxygen species in SH-SY5Y cells...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28928904/depletion-of-the-third-complement-component-ameliorates-age-dependent-oxidative-stress-and-positively-modulates-autophagic-activity-in-aged-retinas-in-a-mouse-model
#3
Dorota Rogińska, Miłosz P Kawa, Ewa Pius-Sadowska, Renata Lejkowska, Karolina Łuczkowska, Barbara Wiszniewska, Kai Kaarniranta, Jussi J Paterno, Christian A Schmidt, Bogusław Machaliński, Anna Machalińska
The aim of the study was to investigate the influence of complement component C3 global depletion on the biological structure and function of the aged retina. In vivo morphology (OCT), electrophysiological function (ERG), and the expression of selected oxidative stress-, apoptosis-, and autophagy-related proteins were assessed in retinas of 12-month-old C3-deficient and WT mice. Moreover, global gene expression in retinas was analyzed by RNA arrays. We found that the absence of active C3 was associated with (1) alleviation of the age-dependent decrease in retinal thickness and gradual deterioration of retinal bioelectrical function, (2) significantly higher levels of antioxidant enzymes (catalase and glutathione reductase) and the antiapoptotic survivin and Mcl-1/Bak dimer, (3) lower expression of the cellular oxidative stress marker-4HNE-and decreased activity of proapoptotic caspase-3, (4) ameliorated retinal autophagic activity with localization of ubiquitinated protein conjugates commonly along the retinal pigment epithelium (RPE) layer, and (5) significantly increased expression of several gene sets associated with maintenance of the physiological functions of the neural retina...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28928903/biomarkers-of-oxidative-stress-in-experimental-models-and-human-studies-with-nutraceuticals-measurement-interpretation-and-significance-2017
#4
EDITORIAL
Ilaria Peluso, Maura Palmery, Gregor Drummen
No abstract text is available yet for this article.
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28928902/collaborative-power-of-nrf2-and-ppar%C3%AE-activators-against-metabolic-and-drug-induced-oxidative-injury
#5
REVIEW
Choongho Lee
Mammalian cells have evolved a unique strategy to protect themselves against oxidative damage induced by reactive oxygen species (ROS). Especially, two transcription factors, nuclear factor erythroid 2p45-related factor 2 (Nrf2) and peroxisome proliferator-activated receptor γ (PPARγ), have been shown to play key roles in establishing this cellular antioxidative defense system. Recently, several researchers reported ameliorating effects of pharmacological activators for these Nrf2 and PPARγ pathways on the progression of various metabolic disorders and drug-induced organ injuries by oxidative stress...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28912935/baicalin-attenuates-subarachnoid-hemorrhagic-brain-injury-by-modulating-blood-brain-barrier-disruption-inflammation-and-oxidative-damage-in-mice
#6
Xianqing Shi, Yongjian Fu, SongSong Zhang, Hao Ding, Jin Chen
In subarachnoid hemorrhagic brain injury, the early crucial events are edema formation due to inflammatory responses and blood-brain barrier disruption. Baicalin, a flavone glycoside, has antineuroinflammatory and antioxidant properties. We examined the effect of baicalin in subarachnoid hemorrhagic brain injury. Subarachnoid hemorrhage was induced through filament perforation and either baicalin or vehicle was administered 30 min prior to surgery. Brain tissues were collected 24 hours after surgery after evaluation of neurological scores...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28904740/low-dose-ionizing-radiation-affects-mesenchymal-stem-cells-via-extracellular-oxidized-cell-free-dna-a-possible-mediator-of-bystander-effect-and-adaptive-response
#7
V A Sergeeva, E S Ershova, N N Veiko, E M Malinovskaya, A A Kalyanov, L V Kameneva, S V Stukalov, O A Dolgikh, M S Konkova, A V Ermakov, V P Veiko, V L Izhevskaya, S I Kutsev, S V Kostyuk
We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apoptosis and DNA double-strand breaks, antiapoptotic gene expression and cell cycle inhibition confirm this hypothesis. We have demonstrated that treatment of mesenchymal stem cells (MSCs) with low doses of IR (10 cGy) leads to cell death of part of cell population and release of oxidized cfDNA...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28904739/role-of-oxidative-stress-and-mitochondrial-dysfunction-in-sepsis-and-potential-therapies
#8
REVIEW
Konstantinos Mantzarlis, Vasiliki Tsolaki, Epaminondas Zakynthinos
Sepsis is one of the most important causes of death in intensive care units. Despite the fact that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and antioxidants play a key role. The imbalance of the abovementioned substances in favor of oxidants is called oxidative stress, and it contributes to sepsis process. The most important consequences are vascular permeability impairment, decreased cardiac performance, and mitochondrial malfunction leading to impaired respiration. Nitric oxide is perhaps the most important and well-studied oxidant...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28904738/total-oxidant-and-antioxidant-status-in-prepubertal-children-with-obesity
#9
Grażyna Rowicka, Hanna Dyląg, Jadwiga Ambroszkiewicz, Agnieszka Riahi, Halina Weker, Magdalena Chełchowska
AIMS: Obesity is accompanied by the formation of oxygen free radicals, whose intensified activity without effective defense mechanisms can lead to oxidative stress and related complications. We evaluated the presence of oxidative stress in obese prepubertal children. METHODS: The study included 83 healthy children aged 2-10 years (62 with obesity and 21 nonobese controls). Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidized low-density lipoprotein (ox-LDL), lipid parameters, glucose, and C-reactive protein (CRP) were measured in serum...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28904737/anticataractogenesis-and-antiretinopathy-effects-of-the-novel-protective-agent-containing-the-combined-extract-of-mango-and-vietnamese-coriander-in-stz-diabetic-rats
#10
Jintanaporn Wattanathorn, Paphaphat Thiraphatthanavong, Wipawee Thukham-Mee, Supaporn Muchimapura, Panakaporn Wannanond, Terdthai Tong-Un
The novel protectant against diabetic cataract and diabetic retinopathy is currently required due to the increased prevalence and therapeutic limitation. Based on the advantage of polyphenol on diabetic eye complications, we hypothesized that the combined extract of mango seed Vietnamese coriander (MPO), a polyphenol-rich substance, should possess anticataractogenesis and antiretinopathy in streptozotocin- (STZ-) diabetic rats. MPO at doses of 2, 10, and 50 mg/kg·BW were orally given to STZ-diabetic rats for 10 weeks...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28904736/beer-polyphenols-and-menopause-effects-and-mechanisms-a-review-of-current-knowledge
#11
REVIEW
Berner Andrée Sandoval-Ramírez, Rosa M Lamuela-Raventós, Ramon Estruch, Gemma Sasot, Monica Doménech, Anna Tresserra-Rimbau
Beer is one of the most frequently consumed fermented beverages in the world, and it has been part of the human diet for thousands of years. Scientific evidence obtained from the development of new techniques of food analysis over the last two decades suggests that polyphenol intake derived from moderate beer consumption may play a positive role in different health outcomes including osteoporosis and cardiovascular risk and the relief of vasomotor symptoms, which are commonly experienced during menopause and are an important reason why women seek medical care during this period; here, we review the current knowledge regarding moderate beer consumption and its possible effects on menopausal symptoms...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28904735/corrigendum-to-immune-profile-of-obese-people-and-in-vitro-effects-of-red-grape-polyphenols-on-peripheral-blood-mononuclear-cells
#12
Thea Magrone, Emilio Jirillo, Anna Spagnoletta, Manrico Magrone, Matteo Antonio Russo, Sergio Fontana, Flavia Laforgia, Ilaria Donvito, Angelo Campanella, Franco Silvestris, Giovanni De Pergola
[This corrects the article DOI: 10.1155/2017/9210862.].
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28900534/resveratrol-enriched-rice-attenuates-uvb-ros-induced-skin-aging-via-downregulation-of-inflammatory-cascades
#13
Lalita Subedi, Taek Hwan Lee, Hussain Mustatab Wahedi, So-Hyeon Baek, Sun Yeou Kim
The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-κB-TNF-α/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28900533/seabuckthorn-paste-protects-lipopolysaccharide-induced-acute-lung-injury-in-mice-through-attenuation-of-oxidative-stress
#14
Leilei Du, Xiaoxin Hu, Chu Chen, Tingting Kuang, Hengfu Yin, Li Wan
Oxidative stress is one of the major mechanisms implicated in endotoxin-induced acute lung injury. Seabuckthorn paste (SP), a traditional Tibetan medicine with high content of polyphenols and remarkable antioxidant activity, is commonly used in treating pulmonary diseases. In the present study, the protective effects and possible underlying mechanisms of SP on lipopolysaccharide- (LPS-) induced acute lung injury in mice were investigated. It was found that body weight loss, lung tissue microstructure lesions, transvascular leakage increase, malondialdehyde augmentation, and the reduction of superoxide dismutase and glutathione peroxidase levels caused by LPS challenge were all consistently relieved by SP treatment in a dose-dependent manner...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28900532/mitochondrial-function-and-mitophagy-in-the-elderly-effects-of-exercise
#15
REVIEW
Osvaldo C Moreira, Brisamar Estébanez, Susana Martínez-Florez, José A de Paz, María J Cuevas, Javier González-Gallego
Aging is a natural, multifactorial and multiorganic phenomenon wherein there are gradual physiological and pathological changes over time. Aging has been associated with a decrease of autophagy capacity and mitochondrial functions, such as biogenesis, dynamics, and mitophagy. These processes are essential for the maintenance of mitochondrial structural integrity and, therefore, for cell life, since mitochondrial dysfunction leads to an impairment of energy metabolism and increased production of reactive oxygen species, which consequently trigger mechanisms of cellular senescence and apoptotic cell death...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28894512/treatment-effects-of-ischemic-stroke-by-berberine-baicalin-and-jasminoidin-from-huang-lian-jie-du-decoction-hljdd-explored-by-an-integrated-metabolomics-approach
#16
Qian Zhang, Xiaowei Fu, Junsong Wang, Minghua Yang, Lingyi Kong
Berberine, baicalin, and jasminoidin were major active ingredients of Huang-Lian-Jie-Du-Decoction (HLJDD), a famous prescription of traditional Chinese medicine (TCM), which has been used for the treatment of ischemic stroke. The aim of the present study was to classify their roles in the treatment effects of ischemic stroke. A rat model of middle cerebral artery occlusion (MCAO) was constructed to mimic ischemic stroke and treatment effects of berberine, baicalin, and jasminoidin, and HLJDD was assessed by neurologic deficit scoring, infarct volume, histopathology, immunohistochemistry, biochemistry, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28894511/the-evaluation-of-antioxidant-and-anti-inflammatory-effects-of-eucommia-ulmoides-flavones-using-diquat-challenged-piglet-models
#17
Daixiu Yuan, Tarique Hussain, Bie Tan, Yanhong Liu, Peng Ji, Yulong Yin
This study was designed to evaluate the antioxidant and anti-inflammatory effects of Eucommia ulmoides flavones (EUF) using diquat-challenged piglet models. A total of 96 weaned piglets were randomly allotted to 1 of 3 treatments with 8 replication pens per treatment and 4 piglets per pen. The treatments were basal diet, basal diet + diquat, and 100 mg/kg EUF diet + diquat. On day 7 after the initiation of treatment, the piglets were injected intraperitoneally with diquat at 8 mg/kg BW or the same amount of sterilized saline...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28894510/antioxidant-and-anti-inflammatory-effects-of-shungite-against-ultraviolet-b-irradiation-induced-skin-damage-in-hairless-mice
#18
Ma Easter Joy Sajo, Cheol-Su Kim, Soo-Ki Kim, Kwang Yong Shim, Tae-Young Kang, Kyu-Jae Lee
As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand. While shungite is regarded as a natural source of fullerene, it remains poorly documented. Here, we explored the in vivo effects of shungite against ultraviolet B- (UVB-) induced skin damage by investigating the physiological skin parameters, immune-redox profiling, and oxidative stress molecular signaling. Toward this, mice were UVB-irradiated with 0.75 mW/cm(2) for two consecutive days...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28894509/effects-of-polyphenol-intake-on-metabolic-syndrome-current-evidences-from-human-trials
#19
REVIEW
Gemma Chiva-Blanch, Lina Badimon
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors which severely increases the risk of type II diabetes and cardiovascular disease. Several epidemiological studies have observed a negative association between polyphenol intake and MetS rates. Nevertheless, there are relatively small numbers of interventional studies evidencing this association. This review is focused on human interventional trials with polyphenols as polyphenol-rich foods and dietary patterns rich in polyphenols in patients with MetS...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28894508/protein-posttranslational-modifications-roles-in-aging-and-age-related-disease
#20
REVIEW
Ana L Santos, Ariel B Lindner
Aging is characterized by the progressive decline of biochemical and physiological function in an individual. Consequently, aging is a major risk factor for diseases like cancer, obesity, and type 2 diabetes. The cellular and molecular mechanisms of aging are not well understood, nor is the relationship between aging and the onset of diseases. One of the hallmarks of aging is a decrease in cellular proteome homeostasis, allowing abnormal proteins to accumulate. This phenomenon is observed in both eukaryotes and prokaryotes, suggesting that the underlying molecular processes are evolutionarily conserved...
2017: Oxidative Medicine and Cellular Longevity
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