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Oxidative Medicine and Cellular Longevity

Ilaria Peluso, Husseen Manafikhi, Anna Raguzzini, Yaroslava Longhitano, Raffaella Reggi, Christian Zanza, Maura Palmery
Despite tea increased plasma nonenzymatic antioxidant capacity, the European Food Safety Administration (EFSA) denied claims related to tea and its protection from oxidative damage. Furthermore, the Supplement Information Expert Committee (DSI EC) expressed some doubts on the safety of green tea extract (GTE). We performed a pilot study in order to evaluate the effect of a single dose of two capsules of a GTE supplement (200 mg × 2) on the peroxidation of leukocytes index ratio (PLIR) in relation to uric acid (UA) and ferric reducing antioxidant potential (FRAP), as well as the sample size to reach statistical significance...
2016: Oxidative Medicine and Cellular Longevity
Tetsuro Kamiya, Michael Courtney, Mikko O Laukkanen
No abstract text is available yet for this article.
2016: Oxidative Medicine and Cellular Longevity
Asmaa Ibrahim Ahmed, Noha N Lasheen, Khaled Mohamed El-Zawahry
Testicular torsion, a surgical emergency, could affect the endocrine and exocrine testicular functions. This study demonstrates histopathological and physiological effects of testicular ischemia/perfusion (I/R) injury and the possible protective effects of Ginkgo biloba treatment. Fifty adult male Wistar rats, 180-200 gm, were randomly divided into sham-operated, Gingko biloba supplemented, ischemia only, I/R, and Gingko biloba treated I/R groups. Overnight fasted rats were anaesthetized by Pentobarbital; I/R was performed by left testis 720° rotation in I/R and treated I/R groups...
2016: Oxidative Medicine and Cellular Longevity
Valéria Nunes-Souza, Natalia Alenina, Fatimunnisa Qadri, Josef M Penninger, Robson Augusto S Santos, Michael Bader, Luiza A Rabelo
Background and Aims. Angiotensin converting enzyme 2 (ACE2) is an important component of the renin-angiotensin system. Since angiotensin peptides have been shown to be involved in hepatic steatosis, we aimed to evaluate the hepatic lipid profile in ACE2-deficient (ACE2(-/y)) mice. Methods. Male C57BL/6 and ACE2(-/y) mice were analyzed at the age of 3 and 6 months for alterations in the lipid profiles of plasma, faeces, and liver and for hepatic steatosis. Results. ACE2(-/y) mice showed lower body weight and white adipose tissue at all ages investigated...
2016: Oxidative Medicine and Cellular Longevity
Ravirajsinh N Jadeja, Kapil K Upadhyay, Ranjitsinh V Devkar, Sandeep Khurana
Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative stress frequently triggers antioxidant response by activating nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, which upregulates various cytoprotective genes. Thus, Nrf2 is considered a potential therapeutic target to halt liver injury. Several studies indicate that activation of Nrf2 signaling pathway ameliorates liver injury. The hepatoprotective potential of naturally occurring compounds has been investigated in various models of liver injuries...
2016: Oxidative Medicine and Cellular Longevity
Fevzi Sarper Türker, Ayşe Doğan, Gonca Ozan, Kurtuluş Kıbar, Mine Erışır
Objective. The purpose of this study is to determine the changes in oxidative damage and antioxidant parameters in open heart surgeries with cardiopulmonary bypass (CPB) in preoperative and early postoperative periods. Methods. A total of three consecutive arterial blood samples were obtained from the patients in the study group, in preoperative, early postoperative, and postoperative periods, respectively. Oxidative damage indicator (MDA) and antioxidant indicators (GPx, GSH, CAT, and SOD) were examined. Results...
2016: Oxidative Medicine and Cellular Longevity
Nicholas Asiimwe, Seung Geun Yeo, Min-Sik Kim, Junyang Jung, Na Young Jeong
Neuronal inflammation is a systematically organized physiological step often triggered to counteract an invading pathogen or to rid the body of damaged and/or dead cellular debris. At the crux of this inflammatory response is the deployment of nonneuronal cells: microglia, astrocytes, and blood-derived macrophages. Glial cells secrete a host of bioactive molecules, which include proinflammatory factors and nitric oxide (NO). From immunomodulation to neuromodulation, NO is a renowned modulator of vast physiological systems...
2016: Oxidative Medicine and Cellular Longevity
Renata Szymanska, Pavel Pospisil, Jerzy Kruk
No abstract text is available yet for this article.
2016: Oxidative Medicine and Cellular Longevity
Jenny Schröter, Jürgen Schiller
Chlorinated phospholipids are formed by the reaction of hypochlorous acid (HOCl), generated by the enzyme myeloperoxidase under inflammatory conditions, and the unsaturated fatty acyl residues or the head group. In the first case the generated chlorohydrins are both proinflammatory and cytotoxic, thus having a significant impact on the structures of biomembranes. The latter case leads to chloramines, the properties of which are by far less well understood. Since HOCl is also widely used as a disinfecting and antibacterial agent in medicinal, industrial, and domestic applications, it may represent an additional source of danger in the case of abuse or mishandling...
2016: Oxidative Medicine and Cellular Longevity
Rafael R Lima, Luana N S Santana, Rafael M Fernandes, Elder M Nascimento, Ana Carolina A Oliveira, Luanna M P Fernandes, Enio Mauricio N Dos Santos, Patrycy Assis N Tavares, Ijair Rogério Dos Santos, Adriano Gimarães-Santos, Walace Gomes-Leal
Stroke is a leading cause of death and neurological disability worldwide and striatal ischemic stroke is frequent in humans due to obstruction of middle cerebral artery. Several pathological events underlie damage progression and a comprehensive description of the pathological features following experimental stroke in both acute and chronic survival times is a necessary step for further functional studies. Here, we explored the patterns of microglial activation, astrocytosis, oligodendrocyte damage, myelin impairment, and Nogo-A immunoreactivity between 3 and 30 postlesion days (PLDs) after experimental striatal stroke in adult rats induced by microinjections of endothelin-1 (ET-1)...
2016: Oxidative Medicine and Cellular Longevity
Daniel Pereira Bezerra, Anne Karine Nascimento Soares, Damião Pergentino de Sousa
Bioactive natural products play critical roles in modern drug development, especially anticancer agents. It has been widely reported that various pharmacological activities of such compounds are related to their antioxidant properties. Vanillin is a natural substance widely found in many plant species and often used in beverages, foods, cosmetics, and pharmaceutical products. Antioxidant and anticancer potential have been described for this compound. Considering the importance of vanillin in the area of human health and food and pharmaceuticals sectors, in this review, we discuss the role of vanillin on redox status and its potential contribution to the prevention and the treatment of cancer...
2016: Oxidative Medicine and Cellular Longevity
Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2016/4867124.].
2016: Oxidative Medicine and Cellular Longevity
Marina Galicia-Moreno, Dorothy Rosique-Oramas, Zaira Medina-Avila, Tania Álvarez-Torres, Dalia Falcón, Fátima Higuera-de la Tijera, Yadira L Béjar, Paula Cordero-Pérez, Linda Muñoz-Espinosa, José Luis Pérez-Hernández, David Kershenobich, Gabriela Gutierrez-Reyes
Alcohol is the most socially accepted addictive substance worldwide, and its metabolism is related with oxidative stress generation. The aim of this work was to evaluate the role of oxidative stress in alcoholic liver cirrhosis (ALC). This study included 187 patients divided into two groups: ALC, classified according to Child-Pugh score, and a control group. We determined the levels of reduced and oxidized glutathione (GSH and GSSG) and the GSH/GSSG ratio by an enzymatic method in blood. Also, protein carbonyl and malondialdehyde (MDA) content were estimated in serum...
2016: Oxidative Medicine and Cellular Longevity
Ewa Skała, Patrícia Rijo, Catarina Garcia, Przemysław Sitarek, Danuta Kalemba, Monika Toma, Janusz Szemraj, Dariusz Pytel, Halina Wysokińska, Tomasz Śliwiński
The essential oils were isolated by hydrodistillation from the hairy roots (HR) and roots of soil-grown plants (SGR) of Rhaponticum carthamoides and were analyzed by GC-MS method. In the both essential oils 62 compounds were identified. The root essential oils showed the differences in the qualitative and quantitative composition. The sesquiterpene hydrocarbons (55-62%) dominated in both essential oils. The major compounds of HR essential oil were cyperene, 13-norcypera-1(5),11(12)-diene, and cadalene while aplotaxene, nardosina-1(10),11-diene, and dauca-4(11),8-diene dominated in SGR essential oil...
2016: Oxidative Medicine and Cellular Longevity
Vojtech Mezera, Rene Endlicher, Otto Kucera, Ondrej Sobotka, Zdenek Drahota, Zuzana Cervinkova
Epigallocatechin gallate (EGCG) is a green tea antioxidant with adverse effects on rat liver mitochondria and hepatocytes at high doses. Here, we assessed whether low doses of EGCG would protect these systems from damage induced by tert-butyl hydroperoxide (tBHP). Rat liver mitochondria or permeabilized rat hepatocytes were pretreated with EGCG and then exposed to tBHP. Oxygen consumption, mitochondrial membrane potential (MMP), and mitochondrial retention capacity for calcium were measured. First, 50 μM EGCG or 0...
2016: Oxidative Medicine and Cellular Longevity
Sultan Alqahtani, Ayman M Mahmoud
Gamma-glutamylcysteine ethyl ester (GCEE) is a precursor of glutathione (GSH) with promising hepatoprotective effects. This investigation aimed to evaluate the hepatoprotective effects of GCEE against cyclophosphamide- (CP-) induced toxicity, pointing to the possible role of peroxisome proliferator activated receptor gamma (PPARγ). Wistar rats were given GCEE two weeks prior to CP. Five days after CP administration, animals were sacrificed and samples were collected. Pretreatment with GCEE significantly alleviated CP-induced liver injury by reducing serum aminotransferases, increasing albumin, and preventing histopathological and hematological alterations...
2016: Oxidative Medicine and Cellular Longevity
Karina Reyes-Gordillo, Ruchi Shah, Ravi Varatharajalu, Mamatha Garige, Leslie C Leckey, M Raj Lakshman
Chronic ethanol-induced downregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) and upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC1β) affect hepatic lipid oxidation and lipogenesis, respectively, leading to fatty liver injury. Low-ω3 fatty acid (Low-ω3FA) that primarily regulates PGC1α and soy protein (SP) that seems to have its major regulatory effect on PGC1β were evaluated for their protective effects against ethanol-induced hepatosteatosis in rats fed with Lieber-deCarli control or ethanol liquid diets with high or low ω3FA fish oil and soy protein...
2016: Oxidative Medicine and Cellular Longevity
Sha Li, Ming Hong, Hor-Yue Tan, Ning Wang, Yibin Feng
The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notably, increasing evidences showed that oxidative stress and inflammation are tightly related, which are regarded as essential partners that present simultaneously and interact with each other in various pathological conditions, creating a vicious cycle to aggravate the hepatic diseases...
2016: Oxidative Medicine and Cellular Longevity
Xiao Tang, Changpo Lin, Daqiao Guo, Ruizhe Qian, Xiaobo Li, Zhenyu Shi, Jianjun Liu, Xu Li, Longhua Fan
A number of recent studies have implicated that autophagy was activated by reactive oxygen species (ROS). Our previous report indicated that CLOCK increased the accumulation of ROS under hypoxic conditions. In this study, we investigated the mechanisms by which CLOCK mediated endothelial damage, focusing on the involvement of oxidative damage and autophagy. Overexpression of CLOCK in human umbilical vein endothelial cells (HUVECs) showed inhibition of cell proliferation and higher autophagosome with an increased expression of Beclin1 and LC3-I/II under hypoxic conditions...
2016: Oxidative Medicine and Cellular Longevity
Juan Cen, Li Zhang, Fangfang Liu, Feng Zhang, Bian-Sheng Ji
Reactive oxygen species (ROS) play an important role in multidrug resistance (MDR). This study aimed to investigate the effects of long-term ROS alteration on MDR in MCF-7 cells and to explore its underlying mechanism. Our study showed both long-term treatments of H2O2 and glutathione (GSH) led to MDR with suppressed iROS levels in MCF-7 cells. Moreover, the MDR cells induced by 0.1 μM H2O2 treatment for 20 weeks (MCF-7/ROS cells) had a higher viability and proliferative ability than the control MCF-7 cells...
2016: Oxidative Medicine and Cellular Longevity
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