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Oxidative Medicine and Cellular Longevity

Rafa S Almeer, Ahmed E Abdel Moneim
In the present investigation, the effect of olive leaf extract (OLE) on testicular damage induced in rats by an intraperitoneal injection of cisplatin ( cis -diamminedichloroplatinum (CDDP)) at a dose of 5 mg/kg was tested. Rats were randomly divided into 4 groups: control, CDDP, OLE, and OLE + CDDP. After 5 days of CDDP treatment, body and testicular weights, histopathological alteration, and serum male sex hormone levels were determined. In addition to the biochemical and immunohistochemical changes in the testes, CDDP caused the disorganization of germinal epithelium and apoptosis by inducing Bax and inhibiting Bcl-2 protein expression...
2018: Oxidative Medicine and Cellular Longevity
Ilona Sadauskiene, Arunas Liekis, Rasa Bernotiene, Jurgita Sulinskiene, Arturas Kasauskas, Gediminas Zekonis
This study was undertaken to investigate the effects of the extracts of buckwheat leaf and flower on the antioxidant status of the brain and liver tissue. The administration of buckwheat extracts (both concentrations were 10%) to mice (at the dose 10 mL/kg of body weight) for 21 days significantly decreased superoxide dismutase (SOD) activity and reduced the amount of glutathione (GSH) and malondialdehyde (MDA) in the mouse brain, while catalase (CAT) activity significantly increased. In the mouse liver, the amount of GSH and activity of SOD increased, while the CAT activity after administering buckwheat leaf and flower extracts was lower in experimental mice than in the control group...
2018: Oxidative Medicine and Cellular Longevity
Jan Borys, Mateusz Maciejczyk, Bożena Antonowicz, Adam Krętowski, Danuta Waszkiel, Piotr Bortnik, Katarzyna Czarniecka-Bargłowska, Magdalena Kocisz, Julita Szulimowska, Marek Czajkowski, Napoleon Waszkiewicz, Anna Zalewska
Due to the high biotolerance, favourable mechanical properties, and osseointegration ability, titanium is the basic biomaterial used in maxillofacial surgery. The passive layer of titanium dioxide on the surface of the implant effectively provides anticorrosive properties, but it can be damaged, resulting in the release of titanium ions to the surrounding tissues. The aim of our work was to evaluate the influence of Ti6Al4V titanium alloy on redox balance and oxidative damage in the periosteum surrounding the titanium miniplates and screws as well as in plasma and erythrocytes of patients with mandibular fractures...
2018: Oxidative Medicine and Cellular Longevity
Elena Alberdi, María Victoria Sánchez-Gómez, Asier Ruiz, Fabio Cavaliere, Carolina Ortiz-Sanz, Tania Quintela-López, Estibaliz Capetillo-Zarate, Santiago Solé-Domènech, Carlos Matute
Amyloid beta- (A β -) mediated ROS overproduction disrupts intraneuronal redox balance and exacerbates mitochondrial dysfunction which leads to neuronal injury. Polyphenols have been investigated as therapeutic agents that promote neuroprotective effects in experimental models of brain injury and neurodegenerative diseases. The aim of this study was to identify the neuroprotective effects of morin and mangiferin against A β oligomers in cultured cortical neurons and organotypic slices as well as their mechanisms of action...
2018: Oxidative Medicine and Cellular Longevity
Márcia Fernanda Correia Jardim Paz, André Luiz Pinho Sobral, Jaqueline Nascimento Picada, Ivana Grivicich, Antonio Luiz Gomes Júnior, Ana Maria Oliveira Ferreira da Mata, Marcus Vinícius Oliveira Barros de Alencar, Rodrigo Mendes de Carvalho, Kátia da Conceição Machado, Muhammad Torequl Islam, Ana Amélia de Carvalho Melo Cavalcante, Juliana da Silva
This study aimed to evaluate DNA damage in patients with breast cancer before treatment (background) and after chemotherapy (QT) and radiotherapy (RT) treatment using the Comet assay in peripheral blood and the micronucleus test in buccal cells. We also evaluated repair of DNA damage after the end of RT, as well as the response of patient's cells before treatment with an oxidizing agent (H2 O2 ; challenge assay). Fifty women with a mammographic diagnosis negative for cancer (control group) and 100 women with a diagnosis of breast cancer (followed up during the treatment) were involved in this study...
2018: Oxidative Medicine and Cellular Longevity
Angela Marino, Silvia Dossena, Grazia Tamma, Sandra Donnini
No abstract text is available yet for this article.
2018: Oxidative Medicine and Cellular Longevity
Erdi Sozen, Burak Yazgan, Ali Sahin, Umit Ince, Nesrin Kartal Ozer
Involvement of high cholesterol and oxidative stress in cardiovascular diseases is well studied, as it can be hypothesized that various products originated from lipid peroxidation, such as oxysterols, or affected protein expression might lead to cardiomyocyte damage followed by the pathological modifications. Although oxidation of excessive cholesterol to oxysterols in elevated stress conditions is identified by a number of studies, the role of a high cholesterol diet in regulating fatty acid and oxysterol accumulation, together with scavenger receptor mRNA levels, in the heart remains little investigated...
2018: Oxidative Medicine and Cellular Longevity
Ioana Adriana Muntean, Ioana Corina Bocsan, Nicolae Miron, Anca Dana Buzoianu, Diana Deleanu
The aim of the study was the analysis of adhesion molecules' profile (ICAM-1, VCAM-1, and E-selectin) in patients with allergic rhinitis and the influence of H1 antihistamines on those markers. Seventy-nine patients with persistent allergic rhinitis (PAR) and 30 healthy volunteers were included in the study. The patients with PAR were treated with desloratadine 5 mg/day or levocetirizine 5 mg/day for 4 weeks. The clinical (rhinitis symptoms and total symptoms score (TSS), type of sensitization) and biological evaluation (total IgE, eosinophils, ICAM-1, VCAM-1, and E-selectin) as well as fractionate nitric oxide in exhaled air (FeNO) measurement was performed before and after treatment...
2018: Oxidative Medicine and Cellular Longevity
Woong Bi Jang, Ji Hye Park, Seung Taek Ji, Na Kyung Lee, Da Yeon Kim, Yeon Ju Kim, Seok Yun Jung, Songhwa Kang, Shreekrishna Lamichane, Babita Dahal Lamichane, Jongseong Ha, Jisoo Yun, Hyung Ryong Moon, Sang Hong Baek, Hae Young Chung, Sang-Mo Kwon
Diabetic cardiomyopathy (DCM) is tightly linked to heart disorders and dysfunction or death of the cardiomyocytes including resident cardiac progenitor cells (CPCs) in diabetic patients. In order to restore loss of function of resident or transplanted CPCs, much research has focused on novel therapeutic strategies including the discovery of novel function-modulating factors such as reactive oxygen species (ROS) scavengers. Here, we developed and defined a novel antioxidant, MHY-1684, for enhancing the angiogenic potential of CPCs against ROS-related DCM...
2018: Oxidative Medicine and Cellular Longevity
Mario Masarone, Valerio Rosato, Marcello Dallio, Antonietta Gerarda Gravina, Andrea Aglitti, Carmelina Loguercio, Alessandro Federico, Marcello Persico
Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD), is a common hepatic condition that encompasses a wide spectrum of presentations, ranging from simple accumulation of triglycerides in the hepatocytes without any liver damage to inflammation, necrosis, ballooning, and fibrosis (namely, nonalcoholic steatohepatitis) up to severe liver disease and eventually cirrhosis and/or hepatocellular carcinoma. The pathophysiology of fatty liver and its progression is influenced by multiple factors (environmental and genetics), in a "multiple parallel-hit model," in which oxidative stress plays a very likely primary role as the starting point of the hepatic and extrahepatic damage...
2018: Oxidative Medicine and Cellular Longevity
Yang Zhang, Yang Liu, Kun Zhu, Yao Dong, Hao Cui, Liping Mao, Xiaoxiao Xu, Hongli Zhou
The paper investigated the preparation, amino acid composition, acute toxicity, and in vitro and in vivo antioxidant, coupled with in vivo antifatigue activities of protein-rich extract of Oviductus ranae (PEOR). The results indicated that PEOR possesses high-safety property with maximum tolerated dose (MTD) higher than 20 g/kg in mice, shows weak scavenging capacities against hydroxyl, superoxide anion, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, as well as ferric-reducing antioxidant power in vitro , but exerts strong antioxidant effect in ethanol-induced oxidative stress mice model; it can decrease malonaldehyde (MDA) and protein carbonyl (PCO) formation and increase total superoxide dismutase (T-SOD) activity and glutathione (GSH) synthesis...
2018: Oxidative Medicine and Cellular Longevity
Ahmed E Zayed, Ahmed Saleh, Asmaa M S Gomaa, Mahmoud Abd-Elkareem, Mamdouh M Anwar, Khaled M A Hassanein, Mohsen M Elsherbiny, Ahmed M Kotb
We aimed in our current study to explore the protective effect of Ginkgo biloba (GB) and magnetized water (MW) against nephrotoxicity associating induced type 2 diabetes mellitus in rat. Here, we induced diabetes by feeding our lab rats on a high fat-containing diet (4 weeks) and after that injecting them with streptozotocin (STZ). We randomly divided forty rats into four different groups: nontreated control (Ctrl), nontreated diabetic (Diabetic), Diabetic+GB (4-week treatment), and Diabetic+MW (4-week treatment)...
2018: Oxidative Medicine and Cellular Longevity
Domingos M S Pereira, Saulo J F Mendes, Khadija Alawi, Pratish Thakore, Aisah Aubdool, Nágila C F Sousa, João F R da Silva, José A Castro, Ione C P Pereira, Luís C N Silva, Marcos A G Grisotto, Valério Monteiro-Neto, Soraia K P Costa, Robson da Costa, João B Calixto, Susan D Brain, Elizabeth S Fernandes
Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions in the host are less well understood. Reduced human Trx activates transient receptor potential canonical 5 (TRPC5) in inflammation, but there is no evidence of whether these receptors mediate bacterial thioredoxin effects in the host. Importantly, TRPC5 can form functional complexes with other subunits such as TRPC4. Herein, E. coli -derived thioredoxin induced mortality in lipopolysaccharide- (LPS-) injected mice, accompanied by reduction of leukocyte accumulation, regulation of cytokine release into the peritoneum, and impairment of peritoneal macrophage-mediated phagocytosis...
2018: Oxidative Medicine and Cellular Longevity
Margarita A Sazonova, Vasily V Sinyov, Anastasia I Ryzhkova, Elena V Galitsyna, Alexandra A Melnichenko, Anton Y Postnov, Alexander N Orekhov, Igor A Sobenin
Modelling of pathological processes in cells is one of the most sought-after technologies of the 21st century. Using models of such processes may help to study the pathogenetic mechanisms of various diseases. The aim of the present study was to analyse the literature, dedicated to obtaining and investigating cybrid models. Besides, the possibility of modeling pathological processes in cells and treatment of different diseases using the models was evaluated. Methods of obtaining Rho0 cell cultures showed that, during their creation, mainly a standard technique, based on the use of mtDNA replication inhibitors (ethidium bromide), was applied...
2018: Oxidative Medicine and Cellular Longevity
Moritz Brandt, Eleni Giokoglu, Venkata Garlapati, Madgalena L Bochenek, Michael Molitor, Lukas Hobohm, Tanja Schönfelder, Thomas Münzel, Sabine Kossmann, Susanne H Karbach, Katrin Schäfer, Philip Wenzel
Pulmonary embolism (PE) results from deep vein thrombosis (DVT) and can lead to chronic thromboembolic pulmonary hypertension (CTEPH) involving vascular dysfunction. Mechanisms are incompletely understood, in part due to lack of mouse models. We induced PE in C57BL/6 mice by intravenous injection of thrombin (166 U/kg BW), confirmed by a sudden bradycardia, bradypnea, and an increase in pulmonary artery (PA) pressure observed by high-frequency ultrasound. While symptoms resolved rapidly after single thrombin application, repeated PEs resulted in sustained PA-pressure increase, increased PA superoxide formation assessed by oxidative fluorescent microtopography, increased PA gp91phox expression, and endothelial dysfunction assessed by isometric tension studies of isolated PA segments after 24 hours...
2018: Oxidative Medicine and Cellular Longevity
Guo-Yu Zhang, Dan Lu, Shao-Feng Duan, Ying-Ran Gao, Shi-Yu Liu, Ya Hong, Peng-Zhen Dong, Ya-Ge Chen, Tao Li, Da-Yong Wang, Xiang-Shu Cheng, Fei He, Jian-She Wei, Guang-Yu Li, Qing-Yong Zhang, Dong-Dong Wu, Xin-Ying Ji
Diaphragm dysfunction is an important clinical problem worldwide. Hydrogen sulfide (H2 S) is involved in many physiological and pathological processes in mammals. However, the effect and mechanism of H2 S in diaphragm dysfunction have not been fully elucidated. In this study, we detected that the level of H2 S was decreased in lipopolysaccharide- (LPS-) treated L6 cells. Treatment with H2 S increased the proliferation and viability of LPS-treated L6 cells. We found that H2 S decreased reactive oxygen species- (ROS-) induced apoptosis through the mitogen-activated protein kinase (MAPK) signaling pathway in LPS-treated L6 cells...
2018: Oxidative Medicine and Cellular Longevity
Lynne Postovit, Christian Widmann, Peng Huang, Spencer B Gibson
No abstract text is available yet for this article.
2018: Oxidative Medicine and Cellular Longevity
Xuling Su, Xin Jiang, Lingbin Meng, Xiaoming Dong, Yanjun Shen, Ying Xin
Sulforaphane (SFN), a compound derived from cruciferous vegetables that has been shown to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its numerous bioactivities, such as anticancer and antioxidant activities. SFN exerts its anticancer effects by modulating key signaling pathways and genes involved in the induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis. SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN...
2018: Oxidative Medicine and Cellular Longevity
L A Ramos-Chávez, R Lugo Huitrón, D González Esquivel, B Pineda, C Ríos, D Silva-Adaya, L Sánchez-Chapul, G Roldán-Roldán, V Pérez de la Cruz
The catabolism of tryptophan has gained great importance in recent years due to the fact that the metabolites produced during this process, with neuroactive and redox properties, are involved in physiological and pathological events. One of these metabolites is kynurenic acid (KYNA), which is considered as a neuromodulator since it can interact with NMDA, nicotinic, and GPR35 receptors among others, modulating the release of neurotransmitters as glutamate, dopamine, and acetylcholine. Kynureninate production is attributed to kynurenine aminotransferases...
2018: Oxidative Medicine and Cellular Longevity
Ning Li, Ling Li, Yongshun Chen
Hepatocellular carcinoma (HCC) is one of the most common malignancies, which causes serious financial burden worldwide. This study aims to investigate the potential mechanisms contributing to HCC and identify core biomarkers. The HCC gene expression profile GSE41804 was picked out to analyze the differentially expressed genes (DEGs). Gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were carried out using DAVID. We constructed a protein-protein interaction (PPI) network to visualize interactions of the DEGs...
2018: Oxidative Medicine and Cellular Longevity
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