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Oxidative Medicine and Cellular Longevity

Xingting Liu, Xin Lin, Yuling Mi, Jian Li, Caiqiao Zhang
Oxidative stress is an important inducement in ovarian aging which results in fecundity decline in human and diverse animals. As a potent antioxidant, grape seed proanthocyanidin extract (GSPE) was investigated to ameliorate chicken ovarian aging in this study. Firstly, ovarian antioxidant capacity of hens at different ages (90, 150, 280, and 580 days old) was compared to elucidate its age-related changes. Subsequently, a D-gal-induced (2.5 mg/mL) aging ovarian model was established and the cultured ovarian tissues were treated with GSPE at 5  μ g/mL for 72 h to evaluate the putative attenuating effects of GSPE on ovarian aging...
2018: Oxidative Medicine and Cellular Longevity
Bassant M Barakat, Hebatalla I Ahmed, Hoda I Bahr, Alaaeldeen M Elbahaie
The current study aimed to investigate the potential protective role of boswellic acids (BAs) against doxorubicin- (DOX-) induced hepatotoxicity. Also, the possible mechanisms underlying this protection; antioxidant, as well as the modulatory effect on the Nrf2 transcription factor/hem oxygenase-1 (Nrf2/HO-1) pathway in liver tissues, was investigated. Animals were allocated to five groups: group 1: the saline control, group 2: the DOX group, animals received DOX (6 mg/kg, i.p.) weekly for a period of three weeks, and groups 3-5: animals received DOX (6 mg/kg, i...
2018: Oxidative Medicine and Cellular Longevity
Zhenquan Jia, Pon Velayutham Anandh Babu, Wei Chen, Xiaolun Sun
No abstract text is available yet for this article.
2018: Oxidative Medicine and Cellular Longevity
Yeong-Min Yoo, Eui-Bae Jeung
The phenotypes of calbindin-D9k - ( CaBP-9k -) knockout (KO), calbindin - D28k - ( CaBP-28k -) KO, and CaBP-9k/28k -KO mice are similar to those of wild-type (WT) mice due to the compensatory action of other calcium transport proteins. In this study, we investigated the expression of cellular prion protein (PrPC ) in the brains of CaBP-9k -, CaBP-28k -, and CaBP-9k/28k -KO mice. PrPC expression was significantly upregulated in the brain of all three strains. Levels of phospho-Akt (Ser473) and phospho-Bad (Ser136) were significantly elevated, but those of phospho-ERK and phospho-Bad (Ser155 and 112) were significantly reduced in the brains of CaBP-9k -, CaBP-28k -, and CaBP-9k/28k -KO mice...
2018: Oxidative Medicine and Cellular Longevity
Bing-Rong Zhou, Li-Wen Ma, Juan Liu, Jia-An Zhang, Yang Xu, Di Wu, Felicia Permatasari, Dan Luo
[This corrects the article DOI: 10.1155/2016/5846865.].
2018: Oxidative Medicine and Cellular Longevity
Himangshu Sonowal, Kirtikar Shukla, Sumedha Kota, Ashish Saxena, Kota V Ramana
Increased side toxicities and development of drug resistance are the major concern for the cancer chemotherapy using synthetic drugs. Therefore, identification of novel natural antioxidants with potential therapeutic efficacies is important. In the present study, we have examined how the antioxidant and anti-inflammatory activities of vialinin A, a p-terphenyl compound derived from Chinese edible mushroom T. terrestris and T. vialis , prevents human umbilical vascular endothelial cell (HUVEC) neovascularization in vitro and in vivo models...
2018: Oxidative Medicine and Cellular Longevity
Christophe Glorieux, Juan Marcelo Sandoval, Nicolas Dejeans, Sandrine Nonckreman, Khadija Bahloula, Hélène A Poirel, Pedro Buc Calderon
Development of cancer cell resistance against prooxidant drugs limits its potential clinical use. MCF-7 breast cancer cells chronically exposed to ascorbate/menadione became resistant (Resox cells) by increasing mainly catalase activity. Since catalase appears as an anticancer target, the elucidation of mechanisms regulating its expression is an important issue. In MCF-7 and Resox cells, karyotype analysis showed that chromosome 11 is not altered compared to healthy mammary epithelial cells. The genomic gain of catalase locus observed in MCF-7 and Resox cells cannot explain the differential catalase expression...
2018: Oxidative Medicine and Cellular Longevity
Simona Ioja, Srikanth Singamsetty, Catherine Corey, Lanping Guo, Faraaz Shah, Michael J Jurczak, Bryan J McVerry, Sruti Shiva, Christopher P O'Donnell
Although acute exposure to hypoxia can disrupt metabolism, longer-term exposure may normalize glucose homeostasis or even improve glucose disposal in the presence of obesity. We examined the effects of two-week exposure to room air (Air), continuous 10% oxygen (C10%), and 12 hr nocturnal periods of 10% oxygen (N10%) on glucose disposal, insulin responsiveness, and mitochondrial function in lean and obese C57BL/6J mice. Both C10% and N10% improved glucose disposal relative to Air in lean and obese mice without evidence of an increase in insulin responsiveness; however, only the metabolic improvements with N10% exposure occurred in the absence of confounding effects of weight loss...
2018: Oxidative Medicine and Cellular Longevity
Sha Li, Hor Yue Tan, Ning Wang, Fan Cheung, Ming Hong, Yibin Feng
Liver disease, involving a wide range of liver pathologies from fatty liver, hepatitis, and fibrosis to cirrhosis and hepatocellular carcinoma, is a serious health problem worldwide. In recent years, many natural foods and herbs with abundant phytochemicals have been proposed as health supplementation for patients with hepatic disorders. As an important category of phytochemicals, natural polyphenols have attracted increasing attention as potential agents for the prevention and treatment of liver diseases. The striking capacities in remitting oxidative stress, lipid metabolism, insulin resistance, and inflammation put polyphenols in the spotlight for the therapies of liver diseases...
2018: Oxidative Medicine and Cellular Longevity
Li-Ching Lin, Chung-Yi Chen, Chia-Hung Kuo, Yun-Sheng Lin, Byeong Hee Hwang, Tina Kaiting Wang, Yueh-Hsiung Kuo, Hui-Min David Wang
N -Hydroxycinnamoylphenalkylamides (36H) exhibited both antioxidation and antityrosinase abilities. The compound was studied for its antioxidative properties, using a 1,1-diphenyl-2-picrylhydrazul- (DPPH-) scavenging test, a ferric ion-reducing antioxidant power assay (FRAP) assessment, and a metal-chelating power assay. The results showed that 36H had antioxidative capabilities in the DPPH-scavenging and ferric-reducing power examinations but the chelating power assay did not demonstrate antioxidative capability...
2018: Oxidative Medicine and Cellular Longevity
Otilia Bobiş, Daniel S Dezmirean, Adela Ramona Moise
Diabetes is a metabolic disorder with multifactorial and heterogeneous etiologies. Two types of diabetes are common among humans: type 1 diabetes that occurs when the immune system attacks and destroys insulin and type 2 diabetes, the most common form, that may be caused by several factors, the most important being lifestyle, but also may be determined by different genes. Honey was used in folk medicine for a long time, but the health benefits were explained in the last decades, when the scientific world was concerned in testing and thus explaining the benefits of honey...
2018: Oxidative Medicine and Cellular Longevity
Ulfuara Shefa, Min-Sik Kim, Na Young Jeong, Junyang Jung
Hydrogen sulfide (H2 S), a toxic gaseous molecule, plays a physiological role in regulating homeostasis and cell signaling. H2 S is produced from cysteine by enzymes, such as cystathionine β -synthase (CBS), cystathionine γ -lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate sulfurtransferase (3MST). These enzymes regulate the overall production of H2 S in the body. H2 S has a cell-signaling function in the CNS and plays important roles in combating oxidative species such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the body...
2018: Oxidative Medicine and Cellular Longevity
Sarfraz Ahmed, Siti Amrah Sulaiman, Atif Amin Baig, Muhammad Ibrahim, Sana Liaqat, Saira Fatima, Sadia Jabeen, Nighat Shamim, Nor Hayati Othman
Honey clasps several medicinal and health effects as a natural food supplement. It has been established as a potential therapeutic antioxidant agent for various biodiverse ailments. Data report that it exhibits strong wound healing, antibacterial, anti-inflammatory, antifungal, antiviral, and antidiabetic effects. It also retains immunomodulatory, estrogenic regulatory, antimutagenic, anticancer, and numerous other vigor effects. Data also show that honey, as a conventional therapy, might be a novel antioxidant to abate many of the diseases directly or indirectly associated with oxidative stress...
2018: Oxidative Medicine and Cellular Longevity
Yung-Ning Yang, Yu-Tsun Su, Pei-Ling Wu, Chun-Hwa Yang, Yu-Chen S H Yang, Jau-Ling Suen, San-Nan Yang
Bacterial meningitis during the perinatal period may cause long-term neurological deficits. The study investigated whether bacterial lipopolysaccharide (LPS) derived from E. coli. led to neuronal apoptosis with an impaired performance of long-term cognitive function involving the activation of histone modification in the TNF- α gene promoter. Further, we looked into the therapeutic efficacy of granulocyte colony-stimulating factor (G-CSF) in a neonatal brain suffering from perinatal bacterial meningitis. We applied the following research techniques: neurobehavioral tasks, confocal laser microscopy, chromatin immunoprecipitation, and Western blotting...
2018: Oxidative Medicine and Cellular Longevity
Luis Fernando Hernández-Zimbrón, Ruben Zamora-Alvarado, Lenin Ochoa-De la Paz, Raul Velez-Montoya, Edgar Zenteno, Rosario Gulias-Cañizo, Hugo Quiroz-Mercado, Roberto Gonzalez-Salinas
Age-related macular degeneration (AMD) is a well-characterized and extensively studied disease. It is currently considered the leading cause of visual disability among patients over 60 years. The hallmark of early AMD is the formation of drusen, pigmentary changes at the macula, and mild to moderate vision loss. There are two forms of AMD: the "dry" and the "wet" form that is less frequent but is responsible for 90% of acute blindness due to AMD. Risk factors have been associated with AMD progression, and they are taking relevance to understand how AMD develops: (1) advanced age and the exposition to environmental factors inducing high levels of oxidative stress damaging the macula and (2) this damage, which causes inflammation inducing a vicious cycle, altogether causing central vision loss...
2018: Oxidative Medicine and Cellular Longevity
Ayse Dogan, Fevzi Sarper Turker
Objective: The aim of the study is to determine the oxidative status in on-pump and off-pump coronary artery surgery and contribute to possible surgical choices in clinical practices in accordance with the information obtained as a result of this study. Methods: 52 patients undergoing open heart surgery (26 patients in on-pump group and 26 patients in off-pump group) were included in the study. MDA, GPx, GSH, CAT, and SOD were investigated in blood samples. Results: In the on-pump group, it was determined that there were a significant increase in MDA level in the peroperative period compared to the preoperative and postoperative periods and a significant increase in GSH level in the postoperative period than in the preoperative period...
2017: Oxidative Medicine and Cellular Longevity
Cuiping Guan, Qingtian Li, Xiuzu Song, Wen Xu, Liuyu Li, Aie Xu
Antroquinonol was investigated as antioxidant and inhibition of inflammatory responses. Our study was to evaluate its immunosuppressive effect on CD8+ T cells and protective effect on depigmentation. CD8+ T cells were treated with antroquinonol in vitro , and C57BL/6 mice were treated with antroquinonol with or without H2 O2 in vivo for 50 consecutive days. We found antroquinonol could inhibit proliferation of CD8+ T cells and suppress the production of cytokines IL-2 and IFN- γ and T cell activation markers CD69 and CD137 in vitro ...
2017: Oxidative Medicine and Cellular Longevity
Barbara Pietrucha, Edyta Heropolitanska-Pliszka, Mateusz Maciejczyk, Halina Car, Jolanta Sawicka-Powierza, Radosław Motkowski, Joanna Karpinska, Marta Hryniewicka, Anna Zalewska, Malgorzata Pac, Beata Wolska-Kusnierz, Ewa Bernatowska, Bozena Mikoluc
This study compared the antioxidant status and major lipophilic antioxidants in patients with ataxia-telangiectasia (AT) and Nijmegen breakage syndrome (NBS). Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and concentrations of coenzyme Q10 (CoQ10) and vitamins A and E were estimated in the plasma of 22 patients with AT, 12 children with NBS, and the healthy controls. In AT patients, TAS (median 261.7 μ mol/L) was statistically lower but TOS (496.8 μ mol/L) was significantly elevated in comparison with the healthy group (312...
2017: Oxidative Medicine and Cellular Longevity
Eun Hye Kim, Seungho Baek, Daiha Shin, Jaewang Lee, Jong-Lyel Roh
Acquired resistance to cisplatin is the most common reason for the failure of cisplatin chemotherapy. Hederagenin, triterpenoids extracted from ivy leaves, exhibits antitumor activity in various types of cancer. However, the therapeutic potential of hederagenin in head and neck cancer (HNC) has remained unclear. Therefore, we examined the effects of hederagenin in cisplatin-resistant HNC cells and characterized its molecular mechanisms of action in this context. We evaluated the effects of hederagenin treatment on cell viability, apoptosis, reactive oxygen species (ROS) production, glutathione levels, mitochondrial membrane potential (Δ Ψ m), and protein and mRNA expression in HNC cells...
2017: Oxidative Medicine and Cellular Longevity
Sun Joo Cha, Hayoung Kim, Hyun-Jun Choi, Sanghyun Lee, Kiyoung Kim
Protein glutathionylation is a redox-mediated posttranslational modification that regulates the function of target proteins by conjugating glutathione with a cysteine thiol group on the target proteins. Protein glutathionylation has several biological functions such as regulation of metabolic pathways, calcium homeostasis, signal transduction, remodeling of cytoskeleton, inflammation, and protein folding. However, the exact role and mechanism of glutathionylation during irreversible oxidative stress has not been completely defined...
2017: Oxidative Medicine and Cellular Longevity
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