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Oxidative Medicine and Cellular Longevity

Thiago Sardinha de Oliveira, Douglas Vieira Thomaz, Hiasmin Franciely da Silva Neri, Letícia Bonancio Cerqueira, Luane Ferreira Garcia, Henric Pietro Vicente Gil, Roberto Pontarolo, Francinete Ramos Campos, Elson Alves Costa, Fernanda Cristina Alcantara Dos Santos, Eric de Souza Gil, Paulo César Ghedini
Pequi ( Caryocar brasiliense ) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. brasiliense leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigated for their antioxidant properties and anticholinesterase activities. The antioxidant properties were evaluated by free radical scavenging and electroanalytical assays, which were further correlated with the total phenolic content and LC-MS results...
2018: Oxidative Medicine and Cellular Longevity
Bo Huang, Weiyang Cai, Qian Wang, Feng Liu, Ming Xu, Yanjie Zhang
Gastric cancer, as a malignant epithelial tumor, is a major health threat leading to poor overall survival and death. It is usually diagnosed at an advanced stage due to asymptomatic or only nonspecific early symptoms. The present study demonstrated that gankyrin contributes to the early malignant transformation of gastric cancer and can be selected to predict the risk of gastric cancer in those patients harboring the precancerous lesions (dysplasia and intestinal metaplasia). In addition, a new insight into gastric cancer was provided, which stated that gankyrin alleviates oxidative stress via mTORC1 pathway activation...
2018: Oxidative Medicine and Cellular Longevity
Amanda L Stefanson, Marica Bakovic
Nuclear factor- (erythroid-derived 2) like 2 (Nrf2) is a transcription factor that regulates the expression of a battery of antioxidant, anti-inflammatory, and cytoprotective enzymes including heme oxygenase-1 (Hmox1, Ho-1) and NADPH:quinone oxidoreductase-1 (Nqo1). The isothiocyanate sulforaphane (SF) is widely understood to be the most effective natural activator of the Nrf2 pathway. Falcarinol (FA) is a lesser studied natural compound abundant in medicinal plants as well as dietary plants from the Apiaceae family such as carrot...
2018: Oxidative Medicine and Cellular Longevity
Senthilkumar Sivanesan, Ravi Mundugaru, Jayakumar Rajadas
Vascular dysfunctions, hypometabolism, and insulin resistance are high and early risk factors for Alzheimer's disease (AD), a leading neurological disease associated with memory decline and cognitive dysfunctions. Early defects in glucose transporters and glycolysis occur during the course of AD progression. Hypometabolism begins well before the onset of early AD symptoms; this timing implicates the vulnerability of hypometabolic brain regions to beta-secretase 1 (BACE-1) upregulation, oxidative stress, inflammation, synaptic failure, and cell death...
2018: Oxidative Medicine and Cellular Longevity
Alessandro Giuseppe Fois, Anna Maria Posadino, Roberta Giordo, Annalisa Cossu, Abdelali Agouni, Nasser Moustafa Rizk, Pietro Pirina, Ciriaco Carru, Angelo Zinellu, Gianfranco Pintus
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by an exacerbated fibrotic response. Although molecular and cellular determinants involved in the onset and progression of this devastating disease are largely unknown, an aberrant remodeling of the pulmonary vasculature appears to have implications in IPF pathogenesis. Here, we demonstrated for the first time that an increase of reactive oxygen species (ROS) generation induced by sera from IPF patients drives both collagen type I deposition and proliferation of primary human pulmonary artery smooth muscle cells (HPASMCs)...
2018: Oxidative Medicine and Cellular Longevity
Pei-Hsun Sung, Tsung-Cheng Yin, Christopher Glenn Wallace, Kuan-Hung Chen, Pei-Lin Shao, Fan-Yen Lee, Cheuk-Kwan Sun, Jiunn-Jye Sheu, Yung-Lung Chen, Mostafa Mohammad Omran, Sheng-Ying Chung, Ching-Jen Wang, Mel S Lee, Hon-Kan Yip
This study tested the hypothesis that extracorporeal shock wave- (ECSW-) assisted adipose-derived stromal vascular fraction (SVF) therapy could preserve left ventricular ejection fraction (LVEF) and inhibit LV remodeling in a rat after acute myocardial infarction (AMI). Adult male SD rats were categorized into group 1 (sham control), group 2 (AMI induced by left coronary artery ligation), group 3 [AMI + ECSW (280 impulses at 0.1 mJ/mm2 , applied to the chest wall at 3 h, days 3 and 7 after AMI), group 4 [AMI + SVF (1...
2018: Oxidative Medicine and Cellular Longevity
Li Sun, Yan-Wei Xu, Jing Han, Chen Xiao, Shan-Shan Cao, Hao Liang, Yan Cheng
Peroxynitrite-mediated nitrosative stress in the brain has been associated with various neurodegenerative disorders. Recent evidence highlights peroxisome proliferator-activated receptor γ (PPAR γ ) as a critical neuroprotective factor in neurodegenerative diseases. Here, we observed the effect of the herb hydroxysafflor yellow A (HSYA) during nitrosative stress in neurons and investigated the mechanism based on PPAR γ protection. We found that a single exposure of primary neurons to peroxynitrite donor SIN-1 caused neuronal injury, which was accompanied by the increase of PPAR γ nitration status and lack of activation of the receptor, as measured by PPAR γ DNA-binding activity, by agonist (15d-PGJ2 or rosiglitazone) stimulation...
2018: Oxidative Medicine and Cellular Longevity
Kai Li, Qiusheng Zheng, Xiaoyu Chen, Yunchao Wang, Dan Wang, Jianning Wang
Prostate carcinoma causes a great number of deaths every year; therefore, there is an urgent need to find new drug candidates to treat advanced prostate cancer. Isobavachalcone (IBC) is the chalcone composition of Psoralea corylifolia Linn used in traditional Chinese medicine. Although IBC demonstrates potent anticancer efficacy in numerous types of human cancer cells, the cellular targets of IBC have not been fully defined. In our study, we found that IBC may induce reactive oxygen species- (ROS-) mediated apoptosis via interaction with a selenocysteine (Sec) containing the antioxidant enzyme thioredoxin reductase 1 (TrxR1), and induce lethal endoplasmic reticulum (ER) stress by inhibiting TrxR1 activity and increasing ROS levels in human prostate cancer PC-3 cells...
2018: Oxidative Medicine and Cellular Longevity
Madhur D Shastri, Shakti Dhar Shukla, Wai Chin Chong, Kamal Dua, Gregory M Peterson, Rahul P Patel, Philip M Hansbro, Rajaraman Eri, Ronan F O'Toole
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis , is the leading cause of mortality worldwide due to a single infectious agent. The pathogen spreads primarily via aerosols and especially infects the alveolar macrophages in the lungs. The lung has evolved various biological mechanisms, including oxidative stress (OS) responses, to counteract TB infection. M. tuberculosis infection triggers the generation of reactive oxygen species by host phagocytic cells (primarily macrophages). The development of resistance to commonly prescribed antibiotics poses a challenge to treat TB; this commonly manifests as multidrug resistant tuberculosis (MDR-TB)...
2018: Oxidative Medicine and Cellular Longevity
Elisabetta Damiani, Francesca Brugè, Ilenia Cirilli, Fabio Marcheggiani, Fabiola Olivieri, Tatiana Armeni, Laura Cianfruglia, Angelica Giuliani, Patrick Orlando, Luca Tiano
Reactive oxygen species (ROS) production in the skin is among the highest compared to other organs, and a clear correlation exists between ROS production and skin aging. Many attempts are underway to reduce oxidative stress in the skin by topical treatment or supplementation with antioxidants/cosmeceuticals, and cultures of human dermal fibroblasts (HDF) are widely used for these studies. Here, we examined the influence of oxygen tension on cell aging in HDF and how this impacted ROS production, the enzymatic and nonenzymatic antioxidant response system, and the efficacy of this defense system in limiting DNA damage and in modulating gene expression of proteins involved in the extracellular matrix, linked to skin aging...
2018: Oxidative Medicine and Cellular Longevity
Iman O Sherif, Nora H Al-Shaalan
The Toll-like receptor-4 (TLR4)/nuclear factor kappa B (NF- κ B) signaling pathway is vital in the pathogenesis of hepatic ischemia/reperfusion (HIR) injury. Dipeptidyl peptidase-4 (DPP4) inhibitors exert protective effects on IR injury of the kidney, heart, and lung; however, their effect on the liver is still unknown. Thus, the purpose of this study was to examine whether pretreatment with vildagliptin (Vilda), a DPP4 inhibitor, produces hepatic protection against IR injury and to investigate its influence on TLR4/NF- κ B signaling in a rat model...
2018: Oxidative Medicine and Cellular Longevity
Ypatios Spanidis, Aristidis S Veskoukis, Christina Papanikolaou, Dimitrios Stagos, Alexandros Priftis, Chariklia K Deli, Athanasios Z Jamurtas, Demetrios Kouretas
Eccentric exercise is a well-studied modality that induces oxidative stress and muscle damage. Furthermore, it promotes inflammatory response in which peripheral blood mononuclear cells (PBMCs) are the major mediators. Although free radicals are necessary in a specific range of concentrations, yet unknown, it remains unclear whether reductive redox status (i.e., increased antioxidant defenses and impaired free radical generation) is beneficial or not. Thus, the aim of the present investigation was to examine the effects of reductive stress and the impact of reduced glutathione (GSH) baseline values on the ability of PBMCs to counteract oxidative stress induced by a potent oxidative agent...
2018: Oxidative Medicine and Cellular Longevity
Hongyang Jiang, Xintao Gao, Jianan Gong, Qian Yang, Ruzhu Lan, Tao Wang, Jihong Liu, Chunping Yin, Shaogang Wang, Zhuo Liu
Solute carrier family 26 member 6 (Slc26a6), which is mainly expressed in the intestines and kidneys, is a multifunctional anion transporter that is crucial in the transport of oxalate anions. This study is aimed at investigating the effect of Slc26a6 expression on oxalate-induced cell oxidation and crystal formation. Lentivirus transfection was used to upregulate or downregulate Slc26a6 expression in NRK cells. Cell viability and apoptosis, reactive oxygen species (ROS) and malondialdehyde (MDA) generation, and superoxide dismutase (SOD) activity were measured...
2018: Oxidative Medicine and Cellular Longevity
José C T Carvalho, Caio P Fernandes, Julio B Daleprane, Maria S Alves, Didier Stien, N P Dhammika Nanayakkara
No abstract text is available yet for this article.
2018: Oxidative Medicine and Cellular Longevity
Omaima Ali, Hebatallah A Darwish, Kamal M Eldeib, Samy A Abdel Azim
Nonalcoholic fatty liver disease (NAFLD) is a metabolic-related disorder ranging from steatosis to steatohepatitis, which may progress to cirrhosis and hepatocellular carcinoma (HCC). This study aimed at assessing the regulatory and protective role of miR-26a on lipid metabolism and progression of NAFLD in human HepG2 cells loaded with free fatty acids (FFA). Lentivirus expressing miR-26a or negative control miR was used to transduce HepG2 cells and to establish stable cell lines. Gain or loss of function using an miR-26a inhibitor was used to compare triglyceride content (TG), total cholesterol level (CL), total antioxidant capacity (TAC), malondialdehyde (MDA) and the level of apoptosis...
2018: Oxidative Medicine and Cellular Longevity
Ilaria Peluso, Anna Raguzzini, Giovina Catasta, Vittoria Cammisotto, Anna Perrone, Carlo Tomino, Elisabetta Toti, Mauro Serafini
High intakes of vegetables have been associated with a lower incidence of cardiovascular diseases (CVD). However, the effect of vegetables on immune function and antioxidant status in human studies have provided contrasting results. In the present study, after a week of run-in period, 38 subjects at risk of CVD were randomly assigned to one of the following 4-week interventions: low vegetable consumption (800 g of vegetables/week) or high vegetable consumption (4200 g of vegetables/week). Vegetables included carrots, topinambur (Jerusalem artichoke, Helianthus tuberosus ), tomatoes, red cabbage, and sweet peppers...
2018: Oxidative Medicine and Cellular Longevity
Po-Yuan Chen, Neng-Lang Shih, Wen-Rui Hao, Chun-Chao Chen, Ju-Chi Liu, Li-Chin Sung
Diabetes-associated cardiac fibrosis is a severe cardiovascular complication. Momordicine I, a bioactive triterpenoid isolated from bitter melon, has been demonstrated to have antidiabetic properties. This study investigated the effects of momordicine I on high-glucose-induced cardiac fibroblast activation. Rat cardiac fibroblasts were cultured in a high-glucose (25 mM) medium in the absence or presence of momordicine I, and the changes in collagen synthesis, transforming growth factor- β 1 (TGF- β 1) production, and related signaling molecules were assessed...
2018: Oxidative Medicine and Cellular Longevity
Anna Straburzyńska-Lupa, Magdalena Paulina Kasprzak, Mateusz Wojciech Romanowski, Anna Kwaśniewska, Wojciech Romanowski, Maria Iskra, Radosław Rutkowski
Purpose: Patients with ankylosing spondylitis (AS) have increased production of proinflammatory cytokines, increased oxidants, and decreased antioxidant capacity. The aim of this study was to determine the effect of whole-body cryotherapy (WBC) at -110°C and -60°C, on disease activity, selected proinflammatory cytokines, and oxidative stress in patients with AS. Methods: Sixty-five patients with AS were recruited to one of three study procedures: WBC at -110°C, -60°C, or exercise therapy (non-WBC)...
2018: Oxidative Medicine and Cellular Longevity
Jintang Wang, Yuetao Song, Zheng Chen, Sean X Leng
Oxidative damage, mitochondrial dysfunction, and neuroinflammation are strongly implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD), and a substantial portion of elderly population at risk of these diseases requires nutritional intervention to benefit health due to lack of clinically relevant drugs. To this end, anti-inflammatory mechanisms of several phytochemicals such as curcumin, resveratrol, propolis, polyunsaturated fatty acids (PUFAs), and ginsenosides have been extensively studied...
2018: Oxidative Medicine and Cellular Longevity
Xinyue Zhang, Jieyu Guo, Xiangxiang Wei, Cong Niu, Mengping Jia, Qinhan Li, Dan Meng
The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes. It has a key regulatory role in the production of reactive oxygen species, cell cycle, heme homeostasis, hematopoiesis, and immunity and has been shown to suppress ischemic angiogenesis and promote breast cancer metastasis. This review summarizes how Bach1 controls these and other cellular and physiological and pathological processes...
2018: Oxidative Medicine and Cellular Longevity
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