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Head & Neck Oncology

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https://www.readbyqxmd.com/read/24723971/immune-cell-infiltration-patterns-and-survival-in-head-and-neck-squamous-cell-carcinoma
#1
Sm Russell, Te Angell, Mg Lechner, Dj Liebertz, Aj Correa, Uk Sinha, N Kokot, Al Epstein
PURPOSE: This study examines the tumour-host immune interactions in head and neck squamous cell carcinoma (HNSCC) and their relationship to human papillomavirus (HPV) infectivity and patient survival. METHODS: The adaptive and innate immune profile of surgical tumour specimens obtained from HNSCC patients was determined using qRT-PCR and immunohistochemistry. Intratumoural and invading margin leukocyte populations (CD3, CD8, CD16, CD20, CD68, FoxP3 and HLA-DR) were quantified and compared with patient disease-specific survival...
February 27, 2013: Head & Neck Oncology
https://www.readbyqxmd.com/read/22742448/effect-of-human-beta-defensin-3-on-head-and-neck-cancer-cell-migration-using-micro-fabricated-cell-islands
#2
Kevin Wang, Joanne H Wang, Harihara Baskaran, Russell Wang, Rick Jurevic
BACKGROUND: To examine the effect of the natural antimicrobial peptide human β-defensin-3 (hBD-3), on the migration of a head and neck cancer cell line in vitro using microfabrication and soft-lithographic techniques. METHODS: TR146 cancer cells were seeded in Petri dishes with microfabricated wells for cell migration assays. Total 54 cell islands were used of various shape and size and experimental media type. Cell migration assays were analyzed in six group media: Dulbecco's modified medium (DMEM); DMEM with vascular endothelial growth factor (VEGF); Conditioned media of human embryonic kidney cells (HEK 239) expressing hBD-3 via transfected cloned pcDNA3 as CM/hBD-3; CM/hBD-3+ VEGF; conditioned medium from non-transfected HEK 239 (not expressing hBD-3) as control (CM); and the last group was CM + VEGF...
June 28, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22731119/feasibility-of-recruitment-to-an-oral-dysplasia-trial-in-the-united-kingdom
#3
Paul Nankivell, Janet Dunn, Michael Langman, Hisham Mehanna
BACKGROUND: Oral epithelial dysplasia (OED) has a malignant potential. Therapeutic options for OED remain both limited and without good evidence. Despite surgery being the most common method of treating OED, recurrence and potentially significant morbidity remain problematic. Consequently, there has been much interest in non-surgical treatments for OED. Cyclo-oxygenase (COX) up-regulation is known to occur in the dysplasia-carcinoma sequence and evidence now exists that COX-2 is a prognostic marker of malignant transformation in OED...
June 25, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22730910/spinal-metastasis-in-thyroid-cancer
#4
REVIEW
Sami Ramadan, Mohamed A Ugas, Richard J Berwick, Manisha Notay, Hyongyu Cho, Waseem Jerjes, Peter V Giannoudis
BACKGROUND: Thyroid carcinoma generally responds well to treatment and spinal metastasis is an uncommon feature. Many studies have looked at the management of spinal metastasis and proposed treatments, plans and algorithms. These range from well-established methods to potentially novel alternatives including bisphosphonates and vascular endothelial growth factor (VEGF) therapy, amongst others.The purposes of this systematic review of the literature are twofold. Firstly we sought to analyse the proposed management options in the literature...
June 25, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22721258/analysis-of-the-compatibility-of-dental-implant-systems-in-fibula-free-flap-reconstruction
#5
Ramin Carbiner, Waseem Jerjes, Kaveh Shakib, Peter V Giannoudis, Colin Hopper
As a result of major ablative surgery, head and neck oncology patients can be left with significant defects in the orofacial region. The resultant defect raises the need for advanced reconstruction techniques. The reconstruction in this region is aimed at restoring function and facial contour. The use of vascularised free flaps has revolutionised the reconstruction in the head and neck. Advances in reconstruction techniques have resulted in continuous improvement of oral rehabilitation. For example, endosteal implants are being used to restore the masticatory function by the way of prosthetic replacement of the dentition...
June 21, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22716187/spinal-metastasis-in-head-and-neck-cancer
#6
REVIEW
Gregory M Trilling, Hyongyu Cho, Mohamed A Ugas, Samerah Saeed, Asia Katunda, Waseem Jerjes, Peter Giannoudis
BACKGROUND: The incidence of head and neck cancer is relatively low in developed countries and highest in South East Asia. Notwithstanding advances in surgery and radiotherapy over the past several decades, the 5-year survival rate for head and neck cancer has stagnated and remains at 50-55%. This is due, in large part, to both regional and distant disease spread, including spinal metastasis. Spinal metastasis from head and neck cancer is rare, has a poor prognosis and can significantly impede end-stage quality of life; normally only palliative care is given...
June 20, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22709938/positron-emission-tomography-in-the-detection-of-occult-primary-head-and-neck-carcinoma-a-retrospective-study
#7
Gabriel Pereira, Joaquim Castro Silva, Eurico Monteiro
BACKGROUND: The management of cervical lymph node metastases from an unknown primary tumor remains a controversial subject. Recently, Positron Emission Tomography (PET) has proved useful in the detection of these tumors, even after an unsuccessful conventional diagnostic workup. This study was performed to assess the role of PET in the detection of occult primary head and neck carcinomas. METHODS: A retrospective analysis of a four year period at a tertiary referral oncology hospital was conducted...
June 18, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22647235/squamous-cell-carcinoma-of-the-oral-cavity-and-the-oropharynx-in-patients-less-than-40-years-of-age-a-20-year-analysis
#8
REVIEW
Samuel E Udeabor, Majeed Rana, Gerd Wegener, Nils-Claudius Gellrich, André M Eckardt
BACKGROUND: Squamous cell carcinoma mainly afflicts patients older than 40 years of age however, few cases are seen in younger patients. The aim of this study therefore was to determine the incidence of squamous cell carcinoma of the oral cavity and oropharynx in patients less than 40 years of age with a view to assessing the prognosis over a period of time. METHODS: This was a 20 years retrospective review of patients who were histologically diagnosed with squamous cell carcinoma of the oral cavity and the oropharynx at the Department of Cranio-Maxillo-Facial Surgery of the Hannover Medical School, Germany and had not received treatment anywhere else...
May 30, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22621416/computed-tomography-and-pathological-findings-of-five-nasal-neurilemmomas
#9
Jing Hu, Yang-Yang Bao, Ke-Jia Cheng, Shui-Hong Zhou, Ling-Xiang Ruan, Zhou-Jun Zheng
OBJECTIVES: Neurilemmomas are benign tumors deriving from Schwann cells of the nerve sheath. They occur in all parts of the body. The highest incidence of neurilemmoma is in the head and neck region (38-45%), but involvement of the nose and paranasal sinus is quite rare, with only sporadic cases having been reported in the world literature. Fewer than 4% of these tumors involve the nasal cavity and paranasal sinuses. We describe the clinical, pathologic, and computed tomography (CT) features of five nasal neurilemmomas...
May 23, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22537656/delay-in-pathological-tissue-processing-time-vs-mortality-in-oral-cancer-short-communication
#10
Waseem Jerjes, Tahwinder Upile, Hani Radhi, Aviva Petrie, Aidan Adams, Jacqueline Callear, Panagiotis Kafas, Colin Hopper
Several factors have been identified to affect morbidity and mortality in oral cancer patients. The time taken to process a resected cancer specimen in a patient presenting with primary or recurrent disease can be of interest as delay can affect earlier interventions post-surgery. We looked at this variable in a group of 168 consecutive oral cancer patients and assessed its relationship to mortality from the disease at 3 and 5 years. It is expected that delay in pathological processing time of surgical specimens acquired from patients with recurrent disease may increase or contribute to the increased rate of mortality...
April 26, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22520362/clear-cell-chondrosarcoma-of-the-head-and-neck
#11
REVIEW
Sepideh Mokhtari, Abbas Mirafsharieh
Clear cell chondrosarcoma is a rare variant of chondrosarcoma that mostly involves the end of long bones. However, nine cases have been reported in the head and neck: four in larynx, two in nasal septum, two in maxilla and one in the skull. These cases form the basis of this review. Head and neck cases accounts for less than 5% of Clear cell chondrosarcomas in the whole body and the larynx is the most common place. The histological findings of head and neck cases are consistent with general features of this entity in the whole body and nearly all tumors in this case series had a component of conventional chondrosarcoma...
April 20, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22515371/a-retrospective-deformable-registration-analysis-of-the-impact-of-pet-ct-planning-on-patterns-of-failure-in-stereotactic-body-radiation-therapy-for-recurrent-head-and-neck-cancer
#12
Kyle Wang, Dwight E Heron, John C Flickinger, Jean-Claude M Rwigema, Robert L Ferris, Gregory J Kubicek, James P Ohr, Annette E Quinn, Cihat Ozhasoglu, Barton F Branstetter
BACKGROUND: Stereotactic body radiation therapy (SBRT) has seen increasing use as a salvage strategy for selected patients with recurrent, previously-irradiated squamous cell carcinoma of the head and neck (rSCCHN). PET-CT may be advantageous for tumor delineation and evaluation of treatment failures in SBRT. We analyzed the patterns of failure following SBRT for rSCCHN and assessed the impact of PET-CT treatment planning on these patterns of failure. METHODS: We retrospectively reviewed 96 patients with rSCCHN treated with SBRT...
April 19, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22452749/primary-squamous-cell-carcinoma-of-thyroid-a-case-report-and-review-of-literature
#13
Mutahir A Tunio, Mushabbab Al Asiri, Mosa Fagih, Rashad Akasha
BACKGROUND: Thyroid gland lacks squamous epithelium (except in some rare situations like embroyonic remnants or in inflammatory processes); for that reason the primary squamous cell carcinoma (SCC) of thyroid is extremely rare entity, seen only in less than 1% of all thyroid malignancies and is considered almost fatal. So, far, only few case reports have been published in literature. CASE PRESENTATION: Herein we present a 54 years old Saudi female with 3 months history of progressive neck swelling and hoarse voice, who was referred to us by her primary care physician as suspected case of anaplastic carcinoma of thyroid for radical external beam radiation therapy (EBRT)...
March 27, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22410339/ctnm-vs-ptnm-the-effect-of-not-applying-ultrasonography-in-the-identification-of-cervical-nodal-disease
#14
Waseem Jerjes, Tahwinder Upile, Hani Radhi, Aviva Petrie, Jesuloba Abiola, Aidan Adams, Jacqueline Callear, Panagiotis Kafas, Syedda Abbas, Kartic Rajaram, Colin Hopper
Accurate clinical staging of oral squamous cell cancer can be quite difficult to achieve especially if nodal involvement is identified. Radiologically-assisted clinical staging is more accurate and informs the clinician of loco-regional and distant metastasis.In this study, we compared clinical TNM (cTNM) staging (not including ultrasonography) to pathological TNM (pTNM) staging in 245 patients presenting with carcinoma of the oral cavity and the oro-pharyngeal region. Tumour size differences and nodal involvement were highlighted...
March 12, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22409767/the-effect-of-tobacco-and-alcohol-and-their-reduction-cessation-on-mortality-in-oral-cancer-patients-short-communication
#15
Waseem Jerjes, Tahwinder Upile, Hani Radhi, Aviva Petrie, Jesuloba Abiola, Aidan Adams, Panagiotis Kafas, Jacqueline Callear, Ramin Carbiner, Kartic Rajaram, Colin Hopper
BACKGROUND: The use of tobacco is known to increase the incidence of developing oral cancer by 6 times, while the additive effect of drinking alcohol further increases the risk leading to higher rate of morbidity and mortality. In this short communication, we prospectively assessed the effect of tobacco smoking and alcohol drinking in oral cancer patients on the overall mortality from the disease, as well as the effect of smoking and drinking reduction/cessation at time of diagnosis on mortality in the same group...
March 12, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22405533/etiology-analysis-and-computed-tomography-imaging-of-a-tonsillar-inflammatory-myofibroblastic-tumor-report-of-an-immunocompetent-patient-and-brief-review
#16
Yun-Zhen Luo, Li-Bo Dai, Shui-Hong Zhou, Xing-Mei Luo, Jun Fan, Ling-Xiang Ruan
OBJECTIVES: The etiology of Inflammatory myofibroblastic tumor(IMT) is contentious. In this study, we used computed tomography (CT) to examine tonsillar IMT and further analyzed the etiology of this entity. METHODOLOGY: We presented CT features of left tonsillar IMT and reviewed the English-language literature published between 1984 and 2011. RESULTS: To our knowledge, there are only six published cases of tonsillar IMT including the present case...
March 9, 2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22726540/p16-overexpression-in-malignant-and-premalignant-lesions-of-the-oral-and-esophageal-mucosa-following-allogeneic-hematopoietic-stem-cell-transplantation
#17
Yasumasa Kakei, Masaya Akashi, Hideki Komatsubara, Tsutomu Minamikawa, Takahide Komori
OBJECTIVES: Secondary malignancy in the oral mucosa is recognized as one of the most serious complications in patients who received allogenic hematopoietic stem cell transplantation (HSCT). However, potential risk factors associated with carcinogenesis after HSCT that have been reported remain elusive. We experienced a rare case of secondary malignancies of the oral and esophageal mucosa and analyzed the expression of tumor suppressor gene product p16. CASE REPORT: A 35-year-old male had malignant lesions of the oral and esophageal mucosa two years after HSCT...
2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22713692/granulocyte-colony-stimulating-factor-producing-squamous-cell-carcinoma-of-the-lower-gingiva-a-case-report
#18
Jun-ichi Kobayashi, Akihiro Miyazaki, Takashi Yamamot, Kenji Nakamori, Rina Suzuki, Takeshi Kaneko, Naohiro Suzuki, Hiroyoshi Hiratsuka
The present study summarizes our experience in treating a patient with a suspected granulocyte colony-stimulating factor (G-CSF)-producing squamous cell carcinoma (SCC) of the lower gingiva, which is a rather rare entity. A 56-year-old woman underwent surgical excision of palate leukoplakia in 1996. In 2009, however, a leukoplakic superficial tumor was detected in the lower left gingiva, for which the patient underwent gingivectomy. This was subsequently diagnosed as SCC. The patient also underwent superselective arterial injection chemotherapy combined with radiotherapy, after local recurrence was observed...
2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22695293/a-patient-with-primary-burkitt-s-lymphoma-of-the-postnasal-space-case-report
#19
Tahwinder Upile, Waseem Jerjes, Jesuloba Abiola, Panagiotis Kafas, Ann Sandison, Zaid Hamdoon, Mohammed Al-Khawalde, Hani Radhi
INTRODUCTION: Burkitt's lymphoma is a highly aggressive lymphoma. The endemic form is present with Epstein - Barr virus. The most common sites are the mandible, facial bones, kidneys, gastrointestinal tract, ovaries, breast and extra-nodal sites. We present the first reported case of a primary Burkitt's lymphoma of the postnasal space occurring in an elderly Caucasian male. CASE PRESENTATION: A 72-year-old Caucasian male farmer presented with a 6-week history of a productive cough and a painless left sided cervical swelling...
2012: Head & Neck Oncology
https://www.readbyqxmd.com/read/22695251/enhanced-patient-reported-outcome-measurement-suitable-for-head-and-neck-cancer-follow-up-clinics
#20
Naseem Ghazali, Derek Lowe, Simon N Rogers
BACKGROUND: The 'Worse-Stable-Better' (W-S-B) question was introduced to capture patient-perceived change in University of Washington Quality of Life (UW-QOL) domains. METHODS: 202 head and neck cancer patients in remission prospectively completed UW-QOL and Patients Concerns Inventory (PCI). For each UW-QOL domain, patients indicated whether over the last month things had worsened (W), remained stable (S) or were better (B). RESULTS: 202 patients at 448 attendances selected 1752 PCI items they wanted to discuss in consultation, and 58% (1024/1752) of these were not covered by the UW-QOL...
2012: Head & Neck Oncology
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