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Journal of Gastrointestinal Cancer

Mohammad Reza Abbaszadegan, Negin Taghehchian, Azadeh Aarabi, Meysam Moghbeli
PURPOSE: Gastric cancer (GC) is the third leading cause of cancer related deaths in the world. Cancer testis antigens (CTAs) are involved in tumor progression of various cancers. These markers have not any expression or minimally expression in normal tissues, highlighting them as efficient methods for molecular targeted therapy. In the present study, we assessed the role of MAEL as a CTA in biology of GC and risk of Helicobacter Pylori (H pylori) infection. METHODS: Levels of MAEL mRNA expression in 80 GC tumor tissues were compared to their corresponding normal margins using the real-time polymerase chain reaction...
November 28, 2018: Journal of Gastrointestinal Cancer
Basem Hassan El-Esawy, Amal Abd El Hafez, Amany Mamdouh Abdelaziz
OBJECTIVES: Mucinous appendiceal tumors (MATs) constitute 0.2-0.3% of appendectomies. This retrospective chart review study determines the incidence of MATs among appendectomies at King Abdul-Aziz Specialist Hospital, Taif City, Saudi Arabia, from January 2009 to December 2014. The clinicopathological features, histopathological criteria, management, outcomes of patients, and the impact of histopathological classification on the follow-up period and recurrence are evaluated. METHODS: Demographic and clinicopathological data were collected from medical records...
November 28, 2018: Journal of Gastrointestinal Cancer
Takeshi Ueda, Takashi Inoue, Takayuki Nakamoto, Naoto Nishigori, Hiroyuki Kuge, Yoshiyuki Sasaki, Hisao Fujii, Fumikazu Koyama
BACKGROUND: Patients with Crohn's disease (CD) are generally known to be at an increased risk of cancer. The anorectal area is the most frequent cancer site in Japanese CD patients. However, the risks are not well defined. The aim of this study was to clarify the clinicopathological characteristics of Japanese CD-associated anorectal carcinoma patients and to explore screening methods for the detection of cancer at earlier stages. METHODS: A systematic review of case series and reports of Japanese CD-associated anorectal cancer patients published between 1983 and 2016 was conducted...
November 26, 2018: Journal of Gastrointestinal Cancer
Elaine Tan, Bassel El-Rayes
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the most aggressive and lethal diseases in the world. The success of immunotherapy in other types of malignancy has led to further trials to understand better the role of immunotherapy in PDAC. However, initial studies with immunotherapy, namely, the checkpoint inhibitors, in PDAC have not been met with the same outcomes. The purpose of this review is to identify and discuss the various resistance mechanisms of PDAC to immunotherapy (pancreatic stroma, genetic predisposition/epigenetics, and the immune inhibitory cells, cytokines, soluble factors, and enzymes that comprise the tumor microenvironment) and the solutions currently being studied to overcome them...
November 17, 2018: Journal of Gastrointestinal Cancer
Usman Hassan, Iftikhar Ali Rana, Sajid Mushtaq, Muhammad Azam, Noreen Akhter
INTRODUCTION: Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm, accounting for only 0.4% of soft-tissue sarcomas. It shows both nodal and extranodal involvement. Considering the rarity and difficulties in diagnosing this tumor, we consider it very important to share our experience of diagnosing FDCS. Its correct diagnosis cannot be overemphasized as the treatment and prognosis of FDCS are very much different from tumors which come in its differential diagnosis. MATERIAL AND METHODS: We are presenting eight cases of extranodal FDCS in gastrointestinal tract diagnosed at our center in a period of 3 years (Feb 2015 to Feb 2018)...
November 15, 2018: Journal of Gastrointestinal Cancer
Farshid Farhan, Reza Ghalehtaki, Shiva Mahdavi-Seresht, Alipasha Meysamie, Maisa Yamrali, Borna Farazmand, Negin Mohammadi, Ehsan Saraee, Mohammad-Reza Mir, Ali Mir, Marzieh Lashkari, Samaneh Salarvand, Ebrahim Esmati, Farhad Samiei
PURPOSE: The optimal treatment for locally advanced GEJ and cardia adenocarcinoma is controversial. Several studies have shown that treating these patients with neoadjuvant chemoradiotherapy followed by surgery leads to survival benefits, and there are also studies that have declared conflicting results. It seems that there is still room for discussion. We calculated the survival rates and pathologic responses in our patients with characteristics which we mentioned above. METHODS: Patients with locally advanced, non-metastatic GEJ and cardia adenocarcinomas (only patients with Siewert's type I and II), who were referred to Imam Khomeini hospital (Institute of cancer) between 2005 and 2014 and received neoadjuvant chemoradiation and underwent surgery were enrolled in this retrospective cohort study...
November 7, 2018: Journal of Gastrointestinal Cancer
Vaibhav Kumar Varshney, Meenakshi Rao, Subhash Chandra Soni, Binit Sureka
No abstract text is available yet for this article.
November 6, 2018: Journal of Gastrointestinal Cancer
Vikas Gupta, K S Vishnu, Thakur D Yadav, Yashwant R Sakaray, Santosh Irrinki, B R Mittal, N Kalra, K Vaiphei
AIM: Thick-walled gallbladder is difficult to characterize on conventional imaging. 18F-FDG PET was used to differentiate benign and malignant wall thickness and compared with histopathology. METHODS: Thirty patients with gallbladder (GB) wall thickening (focal > 4 mm and diffuse > 7 mm), underwents uspected on  ultrasound, or CT scan, and underwent 18F-FDG PET. Histopathology of the specimen was compared with imaging findings. RESULTS: The mean age was 48...
November 6, 2018: Journal of Gastrointestinal Cancer
Maham Hayat, Taseen A Syed, Molly Disbrow, Ngoc Thy Bao Tran, Zain Ul Abideen Asad, William M Tierney
No abstract text is available yet for this article.
November 5, 2018: Journal of Gastrointestinal Cancer
(no author information available yet)
No abstract text is available yet for this article.
November 5, 2018: Journal of Gastrointestinal Cancer
Shaimaa Elzamly, Alireza Torabi, Osvaldo Padilla
No abstract text is available yet for this article.
October 27, 2018: Journal of Gastrointestinal Cancer
AnnaLee Policicchio, Joey Mercier, Antonia Digklia, Ioannis A Voutsadakis
AIMS: To investigate pretreatment platelet and neutrophil counts as well as a combined platelet-neutrophil (PN) index for prognostic information in patients with rectal adenocarcinoma that received neoadjuvant treatment. PATIENTS AND METHODS: Charts from 164 patients with localized rectal adenocarcinoma were retrospectively reviewed, and 112 patients with complete data were included in the study. Patients were stratified in groups according to their neutrophil counts, platelet counts, and a combined platelet/neutrophil (PN) index...
October 24, 2018: Journal of Gastrointestinal Cancer
Mohamed A Chinnaratha, Kirsty Campbell, Ryan Mathias, Rosemary J McCormick, Richard J Woodman, Alan J Wigg
AIM: To assess the overall survival (OS) in those with hepatocellular carcinoma (HCC) diagnosed within a programmatic, centrally co-ordinated, regional screening programme. METHODS: A retrospective cohort analysis of consecutive HCC patients diagnosed between 2004 and 2013. Patients were followed up till death or end of study period (30 April 2015). A dedicated screening programme was commenced in 2009 to screen high-risk patients for HCC. Primary objective is to compare the OS between HCC patients diagnosed within the screening group versus those diagnosed outside this group...
October 22, 2018: Journal of Gastrointestinal Cancer
Abdullah Alsuhaibani, Ahmed Elashwah, Abdullah Alkafi, Camelia Constantinescus, Faisal ALzorkany
OBJECTIVES: We retrospectively evaluate local control rate at 6 months and 1 year in oligometastatic cancer patients treated with SBRT using CyberKnife. METHODS: Total of 21 patients with 24 treatment sites from February 2014 till June 2017 who were treated with SBRT in our institution were included in this study. RESULTS: Eleven patients were males, 10 patients were females, median age at diagnosis was 63 years, and colorectal cancer is the most commonly diagnosed cancer in 18 patients...
October 6, 2018: Journal of Gastrointestinal Cancer
Barbara Kościelniak-Merak, Branimir Radosavljević, Andrzej Zając, Przemysław J Tomasik
BACKGROUND: Early detection of colorectal cancer decreases the risk of mortality. Faecal occult blood tests (FOBT) are recognised as a useful tool for colorectal cancer screening. These non-invasive, rapid, and easy-to-carry assays are very often used as a point-of-care test and for self-testing. On the market, there are various types of FOB tests available, including chemical and immunochromatographic tests, which are based on different detection methods and differ in their sensitivity and specificity...
December 2018: Journal of Gastrointestinal Cancer
Patricia Segales-Rojas, Leonardo S Lino-Silva, Eduardo Aguilar-Cruz, Rosa A Salcedo-Hernández
PURPOSE: Gastrointestinal stromal tumors (GIST) have the potential to recur and metastasize. Several prognostic schemes have been developed but none are precise enough and most times the pathologist faces a small biopsy where it is not possible to evaluate the mitotic count. Our aim was to determine the influence of ki67 index and other clinicopathologic characteristics in the recurrence of GIST. METHODS: Forty-three consecutive cases of GIST were studied. The cases presented with non-metastatic disease...
December 2018: Journal of Gastrointestinal Cancer
Ryan Anthony F Agas, Lester Bryan A Co, J C Kennetth M Jacinto, Kelvin Ken L Yu, Paolo G Sogono, Warren R Bacorro, Teresa T Sy Ortin
PURPOSE: The aim of this study is to review the contemporary evidence comparing neoadjuvant radiotherapy (NRT) versus no radiotherapy (no RT) in patients with stage IV rectal cancer. METHODS: Literature was searched for studies using the following databases: Pubmed, EMBASE, Science Direct, Scopus, ASCOpubs, the Cochrane Library, and Google Scholar. Studies reporting outcomes for stage IV rectal cancer patients who underwent NRT or no RT were selected. RESULTS: A total of eight studies were included in this review (one RCT, five retrospective cohorts, two population-based studies)...
December 2018: Journal of Gastrointestinal Cancer
Bhanu Jayanand Sunil, Ravisankar Palaniappan, Balasubramanian Venkitaraman, Rama Ranganathan
BACKGROUND: Hepatoblastoma is the most common liver malignancy in the pediatric age group. The management of hepatoblastoma involves multidisciplinary approach. METHODS: Patients with hepatoblastoma who underwent liver resection between 2000 and 2013 were analyzed and survival outcomes were studied. RESULTS: The crude incidence rate of hepatoblastoma at the Madras Metropolitan Tumor Registry (MMTR) is 0.4/1,00,000 population per year. Twelve patients underwent liver resection for hepatoblastoma during the study period; this included eight males and four females...
December 2018: Journal of Gastrointestinal Cancer
Ruhi Dixit, Mohd Raza, Mohan Kumar, S Basu, V K Shukla
PURPOSE: Gallbladder cancer is a highly mortal disease with poor prognosis because of late presentation of disease. Survivin and X-linked inhibitor of apoptosis (XIAP) are one of the two important members of inhibitors of apoptosis. Thus, this study aimed to look at the expression of Survivin and XIAP in gallbladder cancer patients. METHODS: Survivin and XIAP expression were investigated in tissues of gallbladder cancer patients (40 cases) and compared with cholelithiasis as control (40 cases) by using immunohistochemistry...
December 2018: Journal of Gastrointestinal Cancer
Pedro L S Usón Junior, Donato Callegaro-Filho, Diogo D G Bugano, Fernando Moura, Fernando C Maluf
INTRODUCTION: Levels of carbohydrate antigen 19-9 (CA19-9) in metastatic pancreatic cancer are used in daily practice as a marker of response to chemotherapy. The association between CA19-9 levels and mortality remains uncertain. This study sought to determine the most accurate level of CA19-9 associated with early mortality, both at diagnosis and during the course of metastatic disease. METHODS: This research is a retrospective analysis of 64 patients with metastatic adenocarcinoma of the pancreas evaluated from January 2010 to December 2015...
December 2018: Journal of Gastrointestinal Cancer
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