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Journal of Gastrointestinal Cancer

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https://www.readbyqxmd.com/read/29218655/a-rare-case-of-a-metastatic-gastrointestinal-stromal-tumor-gist-a-case-report-and-review-of-the-literature
#1
Hamzeh Saraireh, Obada Tayyem, Omar Al Asad, Ranjana Nawgiri, Issam Alawin
No abstract text is available yet for this article.
December 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29218654/mir-200c-as-a-predictive-biomarker-for-5-fluorouracil-chemosensitivity-in-colorectal-cancer
#2
EDITORIAL
Fatemeh Karimi Dermani, Rezvan Najafi
No abstract text is available yet for this article.
December 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29218653/differential-diagnosis-of-pancreatic-epidermoid-cyst-without-a-solid-component-residual-splenic-tissue-vs-mucinous-cystic-neoplasm
#3
Kousei Ishigami, Akihiro Nishie, Hiroyuki Irie, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Daisule Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Tetsuhide Ito, Naoki Mochidome, Hiroshi Honda
PURPOSE: The purpose of this study was to clarify whether there are differences in imaging findings between pancreatic epidermoid cyst (EDC) without a solid component (residual splenic tissue) and mucinous cystic neoplasm (MCN). MATERIALS AND METHODS: The study group consisted of histologically proven EDC (eight cases) and MCN (20 cases). CT and MRI findings were compared on the following imaging findings: the shape of the cystic lesions and the presence or absence of septum, calcification, and high-intensity fluid on T1- and diffusion-weighted images (b factor = 1000)...
December 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29192406/gastric-gastrointestinal-stromal-tumors-gist-a-case-series-and-current-state-of-the-art-in-the-workup-and-treatment-of-this-rare-disease
#4
Neil R Sharma, Harishankar Gopakumar, Scott Harrison, Natalie Ehmke, Christina Zelt
No abstract text is available yet for this article.
December 1, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29177609/disregulation-of-mir-216a-and-mir-217-in-gastric-cancer-and-their-clinical-significance
#5
Reza Safaralizadeh, Naser Ajami, Masoumeh Nemati, Mohammadali Hosseinpourfeizi, Arash Azimzadeh Isfanjani, Seyed-Yaghob Moaddab
OBJECTIVE: The majority of gastric cancer (GC) diagnoses occur at the middle or late stage of the disease, indicating that finding novel biomarkers that could be detectable at earlier stage is urgently needed. Accumulating studies have shown that microRNAs, a class of tiny single-stranded RNAs, play important roles in multiple biological processes including cancer development. The present study aimed to evaluate the effect of miR-216a and miR-217 in GC. MATERIAL AND METHODS: The real-time quantitative reverse-transcription PCR was exploited to identify and compare the expression levels of miR-216a and miR-217 in 37 pairs of samples of gastric cancer tissue and adjacent normal tissue...
November 27, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29177608/identification-of-educational-gaps-among-oncologists-who-manage-patients-with-pancreatic-cancer
#6
Justin A Barnes, Melissa L Ellis, Sharon Hwang, Joan Emarine, Patti Merwin, Gregory D Salinas, Benjamin L Musher
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDA) is associated with poor outcomes and presents oncologists with a myriad of clinical challenges. This study was conducted to assess oncologists' practice patterns and to identify the greatest areas of need for future PDA continuing medical education (CME) programs. METHODS: Case vignettes have been validated as an effective tool to assess how physicians approach and treat a wide array of diseases. In order to assess practice patterns for resectable, locally advanced unresectable, and metastatic PDA, an online case vignette survey was distributed to practicing medical oncologists...
November 27, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29168112/treatment-patterns-and-outcomes-in-patients-with-kras-wild-type-metastatic-colorectal-cancer-treated-in-first-line-with-bevacizumab-or-cetuximab-containing-regimens
#7
Arthur C Houts, Sarika Ogale, Nicolas Sommer, Sacha Satram-Hoang, Mark S Walker
PURPOSE: Patients with Kirsten rat sarcoma viral oncogene wild-type (KRAS WT) metastatic colorectal cancer (mCRC) treated in first line with bevacizumab (B) or cetuximab (C) plus standard chemo backbones had comparable outcomes in phase III Cancer and Leukemia Group B (CALGB) 80405. We examined comparative effectiveness of B and C regimens in real-world community settings. METHODS: This retrospective study examined progression-free survival (PFS) and OS in a US community sample of KRAS WT mCRC patients treated with first-line B (n = 254) or C (n = 146) regimens...
November 22, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29159772/total-pancreatectomy-with-islet-autotransplantation-for-the-ampullary-cancer-a-case-report
#8
Omid Savari, Karolina Golab, Julia Solomina, Evelyn Konsur, Kamil Cieply, Sabarinathan Ramachandran, Zehra Tekin, Lindsay Schenck, Sharon S Zhang, Martin Tibudan, Mitchell C Posner, Piotr Witkowski
No abstract text is available yet for this article.
November 21, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29147979/disappearing-lump-an-unusual-presentation-of-large-metastatic-small-bowel-malignant-melanoma
#9
Narendra Pandit, Sarada Khadka, Rupesh Sah, Lalijan Awale, Sushil Dhakal, Lokesh Shekher Jaiswal, Shailesh Adhikary
No abstract text is available yet for this article.
November 17, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29143916/a-real-world-comparison-of-folfirinox-gemcitabine-plus-nab-paclitaxel-and-gemcitabine-in-advanced-pancreatic-cancers
#10
Ying Wang, Pierre Camateros, Winson Y Cheung
PURPOSE: FOLFIRINOX (FFN), nab-paclitaxel plus gemcitabine (GN), and gemcitabine are three systemic therapies that provide clinically meaningful benefit to patients with unresectable pancreatic cancer (UPC). There are no clinical trials that directly compare the efficacy of all three regimens. In this study, we aim to examine and compare the real-world effectiveness of these treatments. METHODS: Patients diagnosed with UPC who initiated palliative chemotherapy from August 2014 to January 2016 at any one of six cancer centers in British Columbia were identified from the provincial pharmacy...
November 16, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29139058/expression-and-serum-levels-of-mucin-5ac-muc5ac-as-a-biomarker-for-cholangiocarcinoma-a-meta-analysis
#11
Noel Pabalan, Sutawadee Sukcharoensin, Kritiya Butthongkomvong, Hamdi Jarjanazi, Veerachai Thitapakorn
AIM: The potential of biomarkers in detecting early cholangiocarcinoma (CCA) is facilitated by examining CCA-associated proteins from primary studies. One such protein is mucin 5AC (MUC5AC) but inconsistency of reported associations between its expression/serum levels and CCA prompts a meta-analysis to obtain more precise estimates. METHODS: A literature search yielded 17 included articles where multiple data in some raised the number of studies to 22. We calculated pooled odds ratios (OR) and 95% confidence intervals from negative and positive readings of MUC5AC levels...
November 15, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29130142/radiotherapy-for-gastric-bleeding-from-tumor-invasion-of-recurrent-colon-cancer-with-liver-metastasis-after-resection
#12
Osamu Tanaka, Ryoma Yokoi, Tsuyoshi Mukai, Makoto Yamada, Tomohiro Kato, Takuya Taniguchi, Kousei Ono, Masayuki Matsuo
No abstract text is available yet for this article.
November 13, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29127665/hepatocellular-carcinoma-surveillance-experience-from-croatian-referral-centre-for-chronic-liver-diseases
#13
Matea Majerović, Mislav Jelaković, Marina Premužić, Ivana Knežević Štromar, Davor Radić, Marko Mance, Stjepko Pleština, Rajko Ostojić, Nadan Rustemović, Zeljko Krznarić
PURPOSE: For patients at high-risk of developing hepatocellular carcinoma (HCC), biannual ultrasound surveillance has long been recommended, in order to detect the tumor in the early, potentially curative stages. However, globally reported HCC surveillance rates vary greatly, ranging from as low as 1.7 to as high as 80%. Our aim was to assess the utilization of surveillance with biannual ultrasound in high-risk Croatian patients and to identify the factors that impact the implementation of the recommended protocol...
November 11, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29110230/colonic-adenocarcinoma-with-florid-vascular-proliferation-related-to-intussusception
#14
Pallavi Rao, Anisha Sawkar, Srikanth Narayanaswamy, Nandita Ghosal, Sadiq S Sikora
No abstract text is available yet for this article.
November 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29110229/recurrence-of-metastatic-pro-insulinoma-nearly-50%C3%A2-years-after-subtotal-pancreatectomy
#15
Minerva A Romero Arenas, Courtney Olsen, James C Yao
No abstract text is available yet for this article.
November 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29110228/regulatory-fluctuation-of-wnt16-gene-expression-is-associated-with-human-gastric-adenocarcinoma
#16
Seyedeh Elham Norollahi, Majid Alipour, Ali Rashidy-Pour, Ali Akbar Samadani, Laleh Vahedi Larijani
INTRODUCTION: Gastric cancer is one of the most serious and lethal kinds of cancer in the world. It is a multi-step, multi-factor, and elaborated process that is associated to gene abnormal expression. This study intended to investigate the WNT16 gene's expression in human gastric tumor and the margin tissues of the stomach (normal tissues). METHODS: Correspondingly, 40 samples (20 tumoral tissues and 20 non tumoral or margins tissues) were investigated in Imam Khomeini Hospital in Sari City, Mazandaran Province, Iran...
November 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29110227/clinical-factors-as-a-component-of-the-personalized-treatment-approach-to-advanced-pancreatic-cancer-a-systematic-literature-review
#17
REVIEW
William Paul Skelton, Hiral Parekh, Jason S Starr, Jose Trevino, Jessica Cioffi, Steven Hughes, Thomas J George
INTRODUCTION: Pancreatic cancer is often diagnosed at late stages, where disease is either locally advanced unresectable or metastatic. Despite advances, long-term survival is relatively non-existent. DISCUSSION: This review article discusses clinical factors commonly encountered in practice that should be incorporated into the decision-making process to optimize patient outcomes, including performance status, nutrition and cachexia, pain, psychological distress, medical comorbidities, advanced age, and treatment selection...
November 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29110226/is-watchful-waiting-an-option-in-margin-positive-solid-pseudopapillary-neoplasms-of-the-pancreas
#18
LETTER
Rachid G Nagem
No abstract text is available yet for this article.
November 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29110225/a-deregulated-pi3k-akt-signaling-pathway-in-patients-with-colorectal-cancer
#19
Tao Zhang, Yuanping Ma, Jiansong Fang, Chang Liu, Liangrong Chen
BACKGROUND: Molecular switches in phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway may serve as potential targets for the treatment of colorectal cancer (CRC). This study aims to profile the gene alterations involved in PI3K-AKT signaling pathway in patients with CRC. METHODS: Tumoral and matched peritumoral tissues were collected from 15 CRC patients who went routine surgery. A human PI3K-AKT signaling pathway polymerase chain reaction (PCR) array, which profiled the transcriptional changes of a total number of 84 genes involved in the PI3K-AKT pathway, was then applied to determine the gene alterations in CRC tumoral tissue with matched peritumoral tissue as a healthy control...
November 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29110224/role-of-vegf-cd105-and-cd31-in-the-prognosis-of-colorectal-cancer-cases
#20
Salem Y Mohamed, Hanan Lotfy Mohammed, Hanaa M Ibrahim, Elshaimaa M Mohamed, Mona Salah
INTRODUCTION: Colorectal cancer (CRC) incidence is increasing globally. It is ranked as the second most common cancer in women and the third most in men. Angiogenesis plays a significant role in the development and spread of colorectal cancer. Angiogenesis has been proposed as a prognostic marker in a variety of human neoplasms. In this regard, markers of angiogenic endothelial cells are emerging as targets for cancer therapy. AIM OF THE WORK: The aim of this study is to evaluate the prognostic impact of tumor angiogenesis assessed by microvessel density (MVD) counting using CD31 and CD105 along with VEGF immunostaining in colorectal cancer patients...
November 6, 2017: Journal of Gastrointestinal Cancer
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