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Journal of Gastrointestinal Cancer

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https://www.readbyqxmd.com/read/28432610/left-versus-right-does-location-matter-for-refractory-metastatic-colorectal-cancer-patients-in-phase-1-clinical-trials
#1
Sukeshi Patel Arora, Norma S Ketchum, Joel Michalek, Jonathon Gelfond, Devalingam Mahalingam
PURPOSE: Location of the primary tumor is prognostic and predictive of efficacy with VEGF-inhibitors (I) versus EGFR-I given first-line to metastatic colorectal cancer (mCRC) patients. However, little is known regarding the effect of location on prognosis and prediction in refractory mCRC. We assessed the efficacy of VEGF-I and EGFR-I in regards to location of the primary tumor in patients with refractory mCRC enrolled in early phase studies. METHODS: A historical cohort analysis of mCRC patients, including 44 phase I trials our institution, from March 2004 to September 2012...
April 22, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28432609/mesenteric-cystic-teratoma-masquerading-as-acute-abdomen
#2
Vinutha Lakshman, Panduranga Chikkannaiah, Srinivasamurthy Venkataramappa
No abstract text is available yet for this article.
April 22, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28405887/renal-cell-carcinoma-metastatic-to-the-gallbladder
#3
Ben Hazen, Amy Deeken, Andrei Cocieru
No abstract text is available yet for this article.
April 12, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28397102/the-role-of-fluoropirimidines-in-gastrointestinal-tumours-from-the-bench-to-the-bed
#4
REVIEW
Jorge Hernando-Cubero, Ignacio Matos-García, Vicente Alonso-Orduña, Jaume Capdevila
PURPOSE: Gastrointestinal tumours are one of the most common types of cancer. Therapeutic options include surgery, radiotherapy, local ablation techniques, targeted agents, and chemotherapy. Fluoroprimidines are one of the most active drug families in digestive tumours and remains the cornerstone of the most commonly used chemotherapy schemes. METHODS: We review the molecular basis of thymidylate synthase inhibition and the mechanisms of action of 5-fluorouracil, next generation oral fluoropyrimidines (capecitabine, tegafur and the latest S-1 and TAS-102) and antifolates...
April 10, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28374273/metastasis-from-hepatocellular-carcinoma-masquerading-as-a-jugular-paraganglioma
#5
Debashish Chaudhary, Shraddha Patkar, Shailesh V Shrikhande, Mahesh Goel
No abstract text is available yet for this article.
April 4, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28374272/characteristics-and-impacts-of-venous-thromboembolism-in-patients-with-hepatocellular-carcinoma
#6
Yuchen Wang, B M Attar, K Hinami, H E Fuentes, P Jaiswal, H Zhang, C S Simons-Linares, A J Tafur
INTRODUCTION: Venous thromboembolism (VTE) is a common complication in cancer patients, and is associated with worse prognosis in such population. Hepatocellular carcinoma (HCC) poses high risk for VTE; however, data is scarce regarding the characteristics and consequences of VTE in HCC patients. METHOD: We retrospectively reviewed the electronic medical records (EMR) of 270 patients diagnosed with HCC from 2000 to 2015 in Cook County Health and Hospitals System...
April 4, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28367608/primary-extra-gastrointestinal-stromal-tumor-of-mesenteric-root-a-rare-version-of-a-soft-tissue-tumor-located-on-a-critical-region
#7
Yakup Yalcin, Kemal Kursat Bozkurt, Ibrahim Metin Ciris, Sevim Sureyya Cerci, Evrim Erdemoglu
No abstract text is available yet for this article.
April 3, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28367607/patterns-of-presentation-treatment-and-survival-rates-of-gallbladder-cancer-a-prospective-study-at-a-tertiary-care-centre
#8
Santosh Kumar Singh, Rajnish Talwar, Narayanan Kannan, Arvind Kumar Tyagi, Pradeep Jaiswal, Adarsh Kumar
BACKGROUND: India has high incidence of gallbladder carcinoma with regional variation in incidence, the highest in Northern India. This study examines the patterns of presentation, treatment strategies, and survival rate of all patients with gallbladder cancer (GBC) evaluated at our tertiary academic hospital over a period of 2 years. METHODS: All patients presented to our institute with established tissue diagnosis of carcinoma gallbladder were accrued in our study over a time period of 2 years...
April 3, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28361205/caspase-cleaved-cytokeratin-18-fragment-m30-as-a-potential-biomarker-of-macrovascular-invasion-in-hepatocellular-carcinoma
#9
Hatem Elalfy, Tarek Besheer, Mona M Arafa, Mona Abo-Bakr El-Hussiny, Mahmoud Abd El Latif, Sahar Alsayed Mohamed Alsayed
BACKGROUND AND AIM: Extremely poor prognosis in hepatocellular carcinoma (HCC) patients with progressing disease was denoted by vascular invasion. Cytokeratin 18 (CK18) has been shown to be overexpressed in hepatocellular carcinoma so it is a valuable tumor marker; however, its role in vascular invasion is still unclear. This study aimed to predict CK18 as a predictive marker for macrovascular malignant invasion. METHODS: The present study was conducted on three groups of patients: group I included 91 HCC patients without macrovascular invasion, group II included 34 HCC patients with radiological evidence of vascular invasion, and group III included 110 control individuals subdivided into IIIA as healthy blood donors and IIIB as post-HCV cirrhotic patients without HCC...
March 31, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28353162/living-donor-liver-transplantation-for-hepatocellular-carcinoma-with-bile-duct-tumor-thrombi
#10
Ufuk Uylas, Huseyin Kerem Tolan, Volkan Ince, Cuneyt Kayaalp, Sezai Yilmaz
No abstract text is available yet for this article.
March 29, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28349307/pancreatic-tail-neoplasm-masquerading-as-recurrent-splenic-abscesses
#11
Karthik Gnanapandithan, Nishrutha Karthik, Thiruvengadam Muniraj
No abstract text is available yet for this article.
March 28, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28326457/minimally-invasive-surgical-approaches-for-pancreatic-adenocarcinoma-recent-trends
#12
REVIEW
Georgios D Lianos, Dimitrios K Christodoulou, Konstantinos H Katsanos, Christos Katsios, Georgios K Glantzounis
BACKGROUND: Pancreatic resection for cancer represents a real challenge for every surgeon. Recent improvements in laparoscopic experience, minimally invasive surgical techniques and instruments make now the minimally invasive approach a real "triumph." There is no doubt that minimally invasive surgery has replaced with great success conventional surgery in many fields, including surgical oncology. METHODS AND RESULTS: However, its progress in pancreatic resection for adenocarcinoma has been dramatically slow...
March 22, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28315190/posterior-superior-mesenteric-artery-sma-first-approach-vs-standard-pancreaticoduodenectomy-in-patients-with-resectable-periampullary-cancers-a-prospective-comparison-focusing-on-circumferential-resection-margins
#13
Sujoy Pal, Joseph George, Anand Narayan Singh, Sandeep Mathur, Nihar Ranjan Dash, Pramod Garg, Peush Sahni, T K Chattopadhyay
BACKGROUND: The 'SMA-first' (P-SMA) pancreatoduodenectomy (PD) allows dissection directly on the right lateral aspect of superior mesenteric artery (SMA) which may decrease circumferential resection margin (CRM) positivity. This comparative study between standard PD (sPD) and P-SMA approach was planned focusing on CRM involvement. METHODS: This was a prospective study comparing consecutive patients with resectable periampullary cancers (PACA) undergoing PD using the standard or P-SMA approach...
March 18, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28303435/systemic-combination-chemotherapy-in-elderly-pancreatic-cancer-a-review
#14
REVIEW
Gwenalyn Garcia, Marcel Odaimi
PURPOSE: In recent years, significant progress in survival has been achieved using systemic combination chemotherapy in patients with pancreatic cancer. However, the elderly are largely underrepresented in clinical trials, and gains made from these may not necessarily apply to this important subgroup of patients. We review the currently available data regarding contemporary combination chemotherapy regimens, including FOLFIRINOX, gemcitabine plus nab-paclitaxel, nanoliposomal irinotecan plus 5-fluorouracil and leucovorin, and gemcitabine plus capecitabine, in elderly pancreatic cancer patients...
March 16, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28293904/skin-lumps-and-leg-humps-an-unusual-presentation-of-a-common-visceral-malignancy
#15
Aakanksha Goel, Manish Kumar Gaur, Sonal Sharma, Pankaj Kumar Garg
No abstract text is available yet for this article.
March 15, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28283989/occipital-headache-as-initial-manifestation-of-a-pancreatic-neuroendocrine-tumor
#16
Nikolaos Tsoukalas, Agathangelos Triantafyllidis, Maria Tolia, Michail Galanopoulos, Ioannis D Kostakis, Stamatina Demiri, Christos Toumpanakis, Georgios Koumakis
No abstract text is available yet for this article.
March 11, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28229371/overall-survival-and-metastasis-resections-in-patients-with-metastatic-colorectal-cancer-using-electronic-medical-records
#17
Eetu Heervä, Maija Lavonius, Panu Jaakkola, Heikki Minn, Raija Ristamäki
PURPOSE: Treatment for patients with metastatic colorectal cancer is chemotherapy commonly combined with monoclonal antibodies against vascular endothelial growth factor (bevacizumab) or epidermal growth factor receptor (cetuximab or panitumumab), the efficacy of which has been proven in randomized controlled trials. The objective of the current retrospective study was to analyze the impact of targeted therapy, adverse events, and dose reduction on overall survival (OS) and metastasis resection rates...
February 23, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28224462/which-is-important-incision-length-or-oncological-outcome
#18
LETTER
Baris Yildiz, Mesut Tez
No abstract text is available yet for this article.
February 22, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28220295/dnmt3b-579-g-t-promoter-polymorphism-and-the-risk-of-gastric-cancer-in-the-west-of-iran
#19
Kulsom Ahmadi, Azam Soleimani, Shiva Irani, Aliasghar Kiani, Kourosh Ghanadi, Zahra Noormohamadi, Foroozan Sakinejad
BACKGROUND: Many studies have suggested that modulation of DNMT3B function caused by single nucleotide polymorphisms of the DNMT3B promoter region may underlie the susceptibility to various cancers such as tumors of the digestive system. The aim of this study was to investigate the effect of -579 G>T polymorphism in the promoter of the DNMT3B gene on risk of gastric cancer in a population from West Iran. PATIENTS AND METHODS: We conducted a case-control study in 100 gastric cancer patients and 112 cancer-free controls to assess the correlation between DNMT3B -579 G>T (rs1569686) polymorphism and the risk of gastric cancer...
February 21, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28211016/adenocarcinoma-ex-goblet-cell-carcinoid-of-the-appendix-a-case-report-and-overview-of-the-disease
#20
Uroosa Ibrahim, Gautam Valecha, Gwenalyn Garcia, Amina Saqib, Monika Wrzolek, Meekoo Dhar
No abstract text is available yet for this article.
February 17, 2017: Journal of Gastrointestinal Cancer
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