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Journal of Gastrointestinal Cancer

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https://www.readbyqxmd.com/read/29453762/inflammatory-myofibroblastic-tumor-of-the-mid-common-bile-duct-masquerading-as-cholangiocarcinoma
#1
Ritu Verma, Arpita Saha, Kaushik Saha
No abstract text is available yet for this article.
February 17, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29453761/expression-level-of-mir-34a-in-tumor-tissue-from-patients-with-esophageal-squamous-cell-carcinoma
#2
Milad Asadi, Dariush Shanehbandi, Hanieh Mohammadpour, Shahriyar Hashemzadeh, Bita Sepehri
BACKGROUND: miR-34a has been shown to be involved in P53 regulation. In this study, we aimed to evaluate the expression level of miR-34a in esophageal cancer and compare it with that of the normal marginal tissues. METHODS: Tumor and marginal tissues were obtained from 50 patients with esophageal cancer. After RNA extraction, expression level of miR-34a was determined using SYBR green master mix and real-time quantitative PCR. RESULTS: It was observed that there was a downregulation of miR-34a in tumoral tissue of esophageal patients in comparison to normal marginal tissues...
February 17, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29453760/a-tale-of-two-tumors-a-case-of-concomitant-esophageal-squamous-papilloma-and-granular-cell-tumor
#3
LETTER
Kevin T Kline, Eric Gou, Mohammad Bilal, Sreeram Parupudi
No abstract text is available yet for this article.
February 17, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29453759/systemic-treatment-of-patients-with-advanced-unresectable-hepatocellular-carcinoma-emergence-of-therapies
#4
REVIEW
Weijing Sun, Roniel Cabrera
To date, sorafenib, a multiple tyrosine kinase inhibitor, is the only systemic agent approved by the FDA in the first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). Several other tyrosine kinase-inhibiting agents have been investigated in the first-line setting, either alone (sunitinib, brivanib, linifanib, and lenvatinib) or in combination with sorafenib (erlotinib and doxorubicin) in phase 3 trials. However, none of these studies demonstrated an improvement in survival over sorafenib...
February 17, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29441461/superficially-spreading-signet-ring-cell-carcinoma-perpendicularly-colliding-with-gastric-adenoma-a-rare-case-report
#5
Takayuki Minami, Norihiro Yuasa, Eiji Takeuchi, Hideo Miyake, Hidemasa Nagai, Kanji Miyata, Ayami Kiriyama
No abstract text is available yet for this article.
February 14, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29435906/retrospective-assessment-of-the-diagnostic-accuracy-of-the-depth-of-invasion-by-narrow-band-imaging-magnifying-endoscopy-in-patients-with-superficial-esophageal-squamous-cell-carcinoma
#6
Chikatoshi Katada, Satoshi Tanabe, Takuya Wada, Kenji Ishido, Takafumi Yano, Yasuaki Furue, Yuki Kondo, Natsuko Kawanishi, Sakiko Yamane, Akinori Watanabe, Mizutomo Azuma, Wasaburo Koizumi
PURPOSE: Treatment strategies for superficial esophageal squamous cell carcinoma (S-ESCC) are determined mainly on the basis of the depth of invasion. We retrospectively studied the accuracy of the depth of tumor invasion, comprehensively assessed using the Japan Esophageal Society (JES) classification. METHODS: The study group comprised 256 patients who underwent narrow band imaging (NBI) magnifying endoscopy, and endoscopic submucosal dissection for S-ESCC. The depth of invasion of S-ESCC was classified into three groups: EP/LPM, MM/SM1, and SM2...
February 13, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29435905/neuroendocrine-carcinoma-of-gallbladder-a-step-beyond-palliative-therapy-experience-of-25-cases
#7
Amol Vijay Kanetkar, Shraddha Patkar, Krunal Harischandra Khobragade, Vikas Ostwal, Anant Ramaswamy, Mahesh Goel
PURPOSE: Published literature on gall bladder neuroendocrine tumors (GB NETs) is limited with none reporting the role of multimodal therapy. METHODS: Patients with histologically confirmed GB NETs treated at Tata Memorial Hospital, Mumbai, from January 2010 to June 2017 were analyzed. Staging was done by contrast-enhanced computed tomography (CECT) of abdomen and chest or a positron emission topography (PET) scan. Tumor marker (CA19-9) was measured. WHO-2017 guideline was used to classify GB NETs...
February 13, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29427136/molecular-alterations-associated-with-dna-repair-in-pancreatic-adenocarcinoma-are-associated-with-sites-of-recurrence
#8
Margaret D Ferguson, Lei Dong, Jim Wan, Jeremiah L Deneve, Paxton V Dickson, Stephen W Behrman, David Shibata, Mike G Martin, Evan S Glazer
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies with a rising incidence. Mutational analysis of PDAC has provided valuable information but has not yet dramatically changed the therapeutic landscape due to the number of variations detected in any one individual. The pattern of molecular alterations-gene mutations, variations in copy number, and changes in gene expression-has been described in the literature. The purpose of this study is to further investigate the molecular alterations in recurrent or metastatic PDAC based on the site of disease...
February 10, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29417382/squamous-cell-carcinoma-of-colon-an-etiopathological-surprise
#9
Vashisht Dikshit, Iqbal Ali, Chandradip Patil, Kshitij Manerikar, Pratham Mody
No abstract text is available yet for this article.
February 8, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29411249/multi-targeted-tyrosine-kinase-inhibitor-induced-hyperammonemic-encephalopathy-a-report-of-two-cases-using-pazopanib-sunitinib-and-regorafenib
#10
Noppadon Kongsuphon, Maturos Soukavanitch, Noramon Teeraaumpornpunt, Jitprapa Konmun, Touch Ativitavas, Nuttapong Ngamphaiboon
No abstract text is available yet for this article.
February 7, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29404790/microrna-expression-levels-and-histopathological-features-of-colorectal-cancer
#11
Sahar Sarmasti Emami, Abolfazl Akbari, Ali-Akbar Zare, Shahram Agah, Mohsen Masoodi, Atefeh Talebi, Sara Minaeian, Azam Fattahi, Farahnaz Moghadamnia
INTRODUCTION: Non-coding RNAs have opened a new window in cancer biology. MicroRNAs (miRNAs), as a family of non-coding RNAs, play an important role in the gene regulation. The aberrant expression of these small molecules has been documented to involve in colorectal cancer (CRC) pathogenesis. This study aimed to examine the expression of miRNAs in CRC and to correlate their expression levels with histological markers (Ki-67 and CD34). MATERIALS AND METHODS: Tumor tissues and matched normal adjacent tissues were collected from 36 patients with newly diagnosed CRC...
February 6, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29399732/rupture-of-hepatocellular-carcinoma-a-tale-of-20-cases-from-a-tertiary-care-center-in-northern-india
#12
Srimanta Kumar Sahu, S Taneja, N Kalra, R K Dhiman, Y K Chawla, A Duseja, V Singh
No abstract text is available yet for this article.
February 4, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29392602/-duodenal-adenocarcinoma-giving-rise-to-rectal-metastasis-a-rare-disease-with-an-extremely-rare-metastatic-pattern
#13
Cynthia Epskamp, C H J van Eijck, R H J A Sinke, P Hamberg
No abstract text is available yet for this article.
February 2, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29388061/clinical-impact-of-pi3k-braf-mutations-in-ras-wild-metastatic-colorectal-cancer-meta-analysis-results
#14
Amr Mohamed, Brandon Twardy, Nadine AbdAllah, Alaa Akhras, Hibah Ismail, Magdi Zordok, Kelly Schrapp, Taraq Attumi, Anteneh Tesfaye, Bassel El-Rayes
BACKGROUND: Understanding the molecular mechanisms of colorectal cancer has evolved during the last decade ushering the era of personalized medicine. Alteration of BRAF and PI3K is common in colorectal cancer, and can affect several signaling pathways including EGFR (epidermal growth factor receptor). The aim of this meta-analysis is to evaluate the clinical role of PI3K and BRAF mutations in patients with KRAS wild-type metastatic colorectal cancer (MCRC) receiving an EGFR monoclonal antibody (anti-EGFR) inhibitor as first-line therapy...
February 1, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29388060/how-is-rectal-cancer-managed-a-survey-exploring-current-practice-patterns-in-canada
#15
A Crawford, J Firtell, A Caycedo-Marulanda
INTRODUCTION: Locally advanced rectal cancers are most often treated with neoadjuvant chemoradiation followed by surgical resection. However, there are differing opinions surrounding management of rectal cancer, including a lack of consensus on the optimal time interval between chemoradiation and surgery, and the management of patients with complete clinical response following neoadjuvant therapy. This study seeks to summarize management trends for rectal cancer among a sample of Canadian surgeons...
February 1, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29388059/retroperitoneal-mucinous-neoplasm-arising-from-colonic-duplication-cyst
#16
María M Rojas-Rojas, Marcela Mejiah, Martha Mora, Jorge Otero, Fernando Arias-Amézquita, Eduardo Londoño-Schimmer, Paula A Rodríguez-Urrego
No abstract text is available yet for this article.
February 1, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29376207/the-prognostic-implications-of-fix-and-flo-patterns-in-mucinous-colon-carcinomas
#17
Sulen Sarioglu, Guray Akturk, Selman Sokmen, Hulya Ellidokuz, Aras Emre Canda, Mehtat Unlu, Abdullah Haluk Sirin, Ozgul Sagol, Cem Terzi, Mehmet Fuzun
PURPOSE: Colon mucinous carcinomas (MUCs) have two morphological patterns: (i) glands lined by mucinous epithelium with direct contact to the stroma (FIX) and (ii) carcinoma cells floating in mucin (FLO). In this study, we evaluated the prognostic value of these patterns. METHODS: Digital images were captured from the 38 MUC's tissue sections. A grid with 140 points was laid over the computer screen. Totally, 100 points, falling on tumor cells floating in mucin (FLO patterned cells) or on cells contacting stroma (FIX patterned cells), were counted...
January 29, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29374338/intraductal-papillary-neoplasm-of-the-bile-duct-ipnb-case-report-and-literature-review-of-a-challenging-disease-to-diagnose
#18
Ignacio Fuente, Marcos Gonzalez, Martin de Santibañes, Juan Pekolj, Oscar Mazza, Eduardo de Santibañes, Rodrigo Sanchez Claria
No abstract text is available yet for this article.
January 26, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29362985/opium-consumption-and-the-incidence-of-cancer-does-opium-account-as-an-emerging-risk-factor-for-gastrointestinal-cancer
#19
Mohammed Azeez Alzaidi, Hossein Ali Arab, Saeid Amanpour, Shirkoohi Reza, Samad Muhammadnejad, Farhang Sasani
PURPOSE: Some epidemiological studies have shown an association between opium consumption and the incidence of gastrointestinal (GI) cancer. The present study was designed to investigate the effects of opium on the initiation of GI cancer in rats. METHODS: Forty-five rats were randomly divided into three groups; each received different treatment for 40 weeks. The rats in group 1 received purified water, while animals in group 2 were treated with 5 mg/kg diethylnitrosamine (DEN) orally for 8 weeks and continued with purified water by the end of the experiment...
January 24, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29354877/outcomes-of-radioembolization-in-patients-with-chemorefractory-colorectal-cancer-liver-metastasis-a-single-center-experience
#20
Gamze Türk, Gonca Eldem, Saadettin Kılıçkap, Fani Murat Bozkurt, Bilge Volkan Salancı, Barbaros Erhan Çil, Bora Peynircioğlu, Şuayip Yalçın, Ferhun Balkancı
PURPOSE: We aimed to evaluate the efficacy and outcomes of radioembolization with Yttrium-90 (Y-90) microspheres in patients with unresectable and chemorefractory colorectal cancer liver metastasis (CRCLM). METHODS: This single-center study included 43 patients (34 male, 9 female) who underwent radioembolization with Y-90 for unresectable, chemorefractory CRCLM between September 2008 and July 2014. Overall survival (OS), liver progression-free survival (LPFS), overall response rate (ORR), local disease control rate (LDCR), and relations of these parameters with patient disease characteristics were evaluated...
January 22, 2018: Journal of Gastrointestinal Cancer
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