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Journal of Gastrointestinal Cancer

Michael J McNamara, David J Adelstein, Daniela S Allende, Joanna W Bodmann, Denise I Ives, Sudish C Murthy, Daniel Raymond, Siva Raja, Cristina P Rodriguez, Davendra Sohal, Kevin L Stephans, Gregory M M Videtic, Lisa A Rybicki
PURPOSE: Preoperative therapy is frequently employed in the management of esophageal adenocarcinoma. However, many patients are found to have advanced pathologic stage and have poor outcomes. A prognostic factor which identifies this patient population before surgery would be desirable, as alternative treatment strategies may be warranted. METHODS: Between 2/08 and 1/12, 60 evaluable patients with locally advanced esophageal adenocarcinoma enrolled in single-arm phase II trial of induction chemotherapy, surgery, and post-operative adjuvant chemo-radiotherapy (CRT)...
October 12, 2016: Journal of Gastrointestinal Cancer
Fredy Nehme, Joel Alderson, Imad Nassif
No abstract text is available yet for this article.
October 11, 2016: Journal of Gastrointestinal Cancer
Mehmet Artaç, Mükremin Uysal, Mustafa Karaağaç, Levent Korkmaz, Zehra Er, Tunç Güler, Melih Cem Börüban, Hakan Bozcuk
PURPOSE: Metastatic colorectal cancer (mCRC) is a lethal disease and fluorouracil-leucovorin-irinotecan (FOLFIRI) plus bevacizumab (bev) is a standard approach. Hence, there is a strong need for identifying new prognostic factors to show the efficacy of FOLFIRI-bev. METHODS: This is a retrospective study including patients (n = 90) with mCRC from two centers in Turkey. Neutrophil/lymphocyte (N/L) ratio, platelet count, albumin, and C-reactive protein (CRP) were recorded before FOLFIRI-bev therapy...
October 7, 2016: Journal of Gastrointestinal Cancer
Saurabh Zanwar, Mahesh Goel, Shraddha Patkar, Anant Ramaswamy, Nitin Shetty, Mukta Ramadwar, Vikas Ostwal
No abstract text is available yet for this article.
October 7, 2016: Journal of Gastrointestinal Cancer
Tulay Kus, Gokmen Aktas, Mehmet Emin Kalender, Alper Sevinc, Celaletdin Camci
PURPOSE: The aim of this retrospective study was to compare the different treatment options of patients with advanced biliary tract carcinoma (BTC) who were treated with platinum-gemcitabine (CG) or platinum-5-fluorouracil (CF) or 5-Fluorouracil-oxaliplatin-irinotecan (FOLFIRINOX) chemotherapy. METHODS: We included the patients with advanced BTC who were registered at the Department of Oncology in Gaziantep University between January 2008 and January 2016. The following data were analyzed: disease control rate (DCR), progression free survival (PFS) of first and second-line of chemotherapy, and overall survival (OS)...
October 6, 2016: Journal of Gastrointestinal Cancer
Jennifer M Johnson, Jason Chen, Siraj M Ali, Inderpreet K Dardi, Madalina Tuluc, David Cognetti, Barbara Campling, Ashwin R Sama
No abstract text is available yet for this article.
October 6, 2016: Journal of Gastrointestinal Cancer
Su Joa Ahn, Seung Joon Choi, Hyung Sik Kim
PURPOSE: The aim of this study is to evaluate the natural history of untreated pancreatic cancer, with a particular emphasis on the growth rate of primary tumor and development of metastatic disease. METHODS: One hundred patients with histologically proven pancreatic ductal adenocarcinoma examined with at least two CT scans with no intervening treatment were included. Tumor diameters and volumes were measured in CT scans and tumor growth rates and volume doubling times (VDTs) were calculated...
October 4, 2016: Journal of Gastrointestinal Cancer
Nikolaos S Salemis, Georgios Boubousis, Christos Liatsos, Georgios Nakos, Ilias Katikaridis, Nikolaos Tsoukalas
No abstract text is available yet for this article.
September 28, 2016: Journal of Gastrointestinal Cancer
Sahar Esmailzadeh, Behzad Mansoori, Ali Mohammadi, Dariush Shanehbandi, Behzad Baradaran
PURPOSE: Overexpression of HMGA2, known as small non-histone chromosomal protein, is associated with progression of various tumors, including colorectal cancers. The aim of this study was to investigate the effect of a specific HMGA2 siRNA on apoptosis and cell cycle of HCT-116 (colorectal carcinoma) cells. METHODS: The cells were transfected with siRNAs using a transfection reagent. The cytotoxic effects of HMGA2 siRNA on colorectal carcinoma cells were determined using MTT assay...
September 14, 2016: Journal of Gastrointestinal Cancer
Edward M Wolin, Amandine Manon, Christophe Chassaing, Andy Lewis, Laurent Bertocchi, Joel Richard, Alexandria T Phan
PURPOSE: Peptide drugs for antineoplastic therapies usually have low oral bioavailability and short in vivo half-lives, requiring less preferred delivery methods. Lanreotide depot is a sustained-release somatostatin analog (SSA) formulation produced via an innovative peptide self-assembly method. Lanreotide is approved in the USA and Europe to improve progression-free survival (PFS) in patients with unresectable gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and also approved in Europe for symptom control in carcinoid syndrome associated with GEP-NETs...
September 13, 2016: Journal of Gastrointestinal Cancer
Somayeh Salehi, Amir Hossein Jafarian, Mehdi Montazer, Meysam Moghbeli, Mohammad Mahdi Forghanifard
PURPOSE: Evading apoptosis is one of the major hallmarks of cancer cells. Inhibitors of apoptosis (IAPs) proteins are considered as a most important gene families involved in apoptosis. BRUCE protein, a member of IAPs, is able to quench apoptosis as well as playing role in cell division. Our aim in this study was to analyze BRUCE protein expression in gastric carcinoma (GC) and its correlation with the clinicopathological features. METHODS: Using immunohistochemistry, 52 GC specimens were studied for BRUCE protein expression...
September 10, 2016: Journal of Gastrointestinal Cancer
Ahmed Abdel-Razik, Nasser Mousa, Hatem Elalfy, Tarek Fouad Sheta, Mahmoud Awad, Mostafa Abdelsalam, Rania Elhelaly, Rasha Elzehery, Nawal S Gouda, Waleed Eldars
BACKGROUND AND AIMS: Ascites with unknown cause remains a diagnostic challenge, which needs novel noninvasive biomarkers for the precise diagnosis. We aimed to evaluate the ascitic fluid and serum C-reactive protein (CRP) and vascular endothelial growth factor (VEGF) as diagnostic markers in the differential diagnosis of malignant and benign ascites. METHODS: In this prospective work, 315 consecutive patients with ascites were studied. Ascitic fluid and serum levels of CRP and VEGF were evaluated by using an enzyme-linked immunosorbent assay...
September 10, 2016: Journal of Gastrointestinal Cancer
Jon Arne Søreide, Erling Sandøy Undersrud, Mohammed S S Al-Saiddi, Tore Tholfsen, Kjetil Søreide
PURPOSE: Primary mesenchymal tumors of the pancreas are rare, with leiomyosarcomas the most encountered entities among the pancreatic sarcomas. With few exceptions, single case reports published over the last six decades constitute the entire scientific literature on this topic. Thus, evidence regarding clinical decision-making is scant. METHODS: Based on a case report and an extensive literature search in PubMed, we discuss the clinical aspects and current management of this rare malignancy...
September 9, 2016: Journal of Gastrointestinal Cancer
Abhinav Dewan, S K Sharma, A K Dewan, Ruparna Khurana, Manoj Gupta, Anjali Pahuja, Himanshu Srivastava, Rupal Sinha
BACKGROUND: Neoadjuvant chemoradiation (NCRT) has been shown to improve survival in patients with locally advanced esophageal squamous cell carcinoma (SCC). The aim of the present study was to evaluate the role of 18-FDG PET-CT in predicting pathological response to NCRT. MATERIAL AND METHODS: We assessed 70 patients of esophageal SCC who underwent NCRT and were evaluated with baseline and post chemoradiation 18F-FDG PET-CT scan. Receiver operating characteristic (ROC) curve was generated by analyzing the sensitivity and specificity of different cut-off points for defining a positive test and their ability to predict pathological complete response...
September 8, 2016: Journal of Gastrointestinal Cancer
Tarik Adioui, Mouna Tamzaourte, Fouad Nejjari, Amal Chakkor, Hakim Elkaoui, Adil Boudhas, Mohamed Oukabli, Fedoua Rouibaa, Aziz Aourarh, Aziz Zentar
No abstract text is available yet for this article.
August 31, 2016: Journal of Gastrointestinal Cancer
Zahra Shahhoseini, Fereshteh Jeivad, Nematollah Ahangar, Saeid Abediankenari
PURPOSE: Octamer binding transcription factor B gene (OCT4) is responsible for development and self-renewal maintenance of embryonic stem cells. The rs3130932 single nucleotide polymorphism (SNP) may play a role in tumor genesis. Because of high prevalence of gastric cancer in north of Iran, this study was investigated role of rs3130932 polymorphism and stomach cancer. METHODS: Blood samples were collected from 100 informed gastric cancer patients and 100 age and sex-matched healthy individuals, and were genotyped for the presence of rs3130932G allele by ssp PCR...
August 30, 2016: Journal of Gastrointestinal Cancer
Mozaffar Aznab, Omid Beiki, Kiumars Eslam Pia, Khosro Setayeshi, Mohamad Ali Hesami, Houshang Vrae
AIM: Our aim was to evaluate impact of chemotherapy (5-fluorouracil plus docetaxel and cisplatin) on the survival of gastric cancer cases. METHOD: Seventy-nine patients were eligible to take part in this study between November 2006 and April 2013, who received 5-fluorouracil (700 mg/m(2), 21-h infusion within 5 days), cisplatin (60 mg/m(2) on day 3), and Docetaxel (60 mg/m(2) on day 2). Radiotherapy was added to the treatment only in the cases with entire stomach body cancer (positive margin) and with giant ulcer (above 50 mm) in proximal gastric cancer...
August 20, 2016: Journal of Gastrointestinal Cancer
James M Pauff, Laura W Goff
PURPOSE: Biliary tract cancers (BTC) remain one of the poorest groups of malignancies in terms of long-term survival, with only limited success in improvements by the use of systemic chemotherapy and our current repertoire of molecularly targeted therapies. Treatments that aim to adapt the patient's own immune system to target cancer cell have shown tremendous promise in treating solid tumors such as melanoma and non-small cell lung cancer, and there are many recently completed and ongoing studies looking to move immunotherapy into the treatment of BTC...
August 19, 2016: Journal of Gastrointestinal Cancer
Sudhamshi Toom, Yiqing Xu
No abstract text is available yet for this article.
August 12, 2016: Journal of Gastrointestinal Cancer
Murad A Jabir, Hesham M Hamza, Hussein Fakhry, Gamal Amira, Etsuro Hatano, Shinji Uemoto
PURPOSE: In this study, we aim to report the efficacy of using the anterior approach (AA) versus the conventional approach (CA), in surgical resection for large hepatocellular carcinoma (HCC) (≥7 cm) of the right hepatic lobe in terms of surgical and long-term outcomes. MATERIALS AND METHODS: Between 2000 and 2006, 138 consecutive patients who underwent hepatic resection with curative intent for large right lobe HCC ≥7 cm were identified from a retrospective database...
August 10, 2016: Journal of Gastrointestinal Cancer
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