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Journal of Otolaryngology—Head & Neck Surgery

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https://www.readbyqxmd.com/read/29228990/mannitol-and-the-blood-labyrinth-barrier
#1
Trung N Le, Brian W Blakley
BACKGROUND: Characterization of the blood labyrinth barrier (BLB) is extremely important to determine whether the BLB can be manipulated pharmacologically. However, experiments to investigate the BLB are technically difficult to perform. In this report, we demonstrated a unique method of controlling the BLB, and established the pharmacokinetics of gentamicin in perilymph, cerebrospinal fluid (CSF) and blood with and without mannitol. STUDY DESIGN: Controlled animal research project...
December 11, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29202870/clinical-predictors-of-chronic-rhinosinusitis-do-the-canadian-clinical-practice-guidelines-for-acute-and-chronic-rhinosinusitis-predict-ct-confirmation-of-disease
#2
Paige Moore, Brian Blakley, Eric Meen
BACKGROUND: The diagnosis of chronic rhinosinusitis (CRS) based on clinical presentation alone remains challenging. To improve the accuracy of clinical diagnosis, the Canadian Rhinosinusitis Guidelines recommend the use of specific symptom and endoscopic criteria. Our study objective was to determine whether symptom and endoscopic criteria, as defined by the Canadian Rhinosinusitis Guidelines, accurately predict CT-confirmed CRS diagnosis. METHODS: A retrospective cohort study of 126 patients who underwent CT sinuses based on clinical suspicion of possible CRS...
December 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29178954/the-effectiveness-of-topical-colloidal-silver-in-recalcitrant-chronic-rhinosinusitis-a-randomized-crossover-control-trial
#3
John R Scott, Rohin Krishnan, Brian W Rotenberg, Leigh J Sowerby
BACKGROUND: Recalcitrant chronic rhinosinusitis without polyposis (CRSsP) is a challenging condition to manage as traditional medical therapies and surgery fail to provide satisfactory clinical improvements. Colloidal silver (CS), a widely used naturopathic agent, has recently shown anti-biofilm properties both in vitro and within a rhinosinusitis animal model. To date, no trials involving humans have been published in world literature. The purpose of this study was to assess the efficacy of CS as a topical nasal spray in patients with refractory CRSsP...
November 25, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29166946/noise-exposure-while-commuting-in-toronto-a-study-of-personal-and-public-transportation-in-toronto
#4
Christopher M K L Yao, Andrew K Ma, Sharon L Cushing, Vincent Y W Lin
BACKGROUND: With an increasing proportion of the population living in cities, mass transportation has been rapidly expanding to facilitate the demand, yet there is a concern that mass transit has the potential to result in excessive exposure to noise, and subsequently noise-induced hearing loss. METHODS: Noise dosimetry was used to measure time-integrated noise levels in a representative sample of the Toronto Mass Transit system (subway, streetcar, and buses) both aboard moving transit vehicles and on boarding platforms from April - August 2016...
November 23, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29166927/safety-of-transtympanic-application-of-probiotics-in-a-chinchilla-animal-model
#5
Carol Nhan, Aren Bezdjian, Shyamali Saha, Satya Prakash, Lily H P Nguyen, Sam J Daniel
BACKGROUND: Chronic suppurative otitis media can be recalcitrant and difficult to treat, particularly with the increasing occurrence of antibiotic resistance. Lactobacillus plantarum is a probiotic that has been shown to decrease S. aureus and P. aeruginosa growth in wounds, making it a good candidate for the treatment of chronic suppurative otitis media. However, before it can be applied in the ear, its ototoxicity potential must be evaluated. METHODS: A prospective controlled trial was conducted in a chinchilla animal model at the Animal care research facilities of the Montreal Children's Hospital Research Institute to determine whether Lactobacillus plantarum is ototoxic when applied transtympanically...
November 22, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29073940/practices-regarding-human-papillomavirus-counseling-and-vaccination-in-head-and-neck-cancer-a-canadian-physician-questionnaire
#6
Scott Anderson, Andre Isaac, Caroline C Jeffery, Joan L Robinson, Daniela Migliarese Isaac, Christina Korownyk, Vincent L Biron, Hadi Seikaly
BACKGROUND: Human papillomavirus (HPV) has recently been implicated as a causative agent in a rapidly growing number of oropharyngeal cancers. Emerging literature supports the hypothesis that HPV vaccination may protect against HPV-related head and neck cancer (HNC) in addition to HPV-related cervical and anogenital disease. While the association between HPV infection and cervical cancer is widely understood, its relation to HNC is less well known. The purpose of this study was to better understand HPV counseling practices for infection and vaccination in relation to HNC of primary care physicians (PCPs), Obstetricians/Gynecologists (OBGYNs), and Otolaryngology - Head and Neck Surgeons (OHNSs) in Canada...
October 26, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29061193/subtotal-parathyroidectomy-and-relocation-of-the-parathyroid-remnant-for-renal-hyperparathyroidism-modification-of-a-traditional-operation
#7
Tsu-Hui Hubert Low, John Yoo
BACKGROUND: We describe a modification of the conventional subtotal parathyroidectomy operation where the parathyroid gland(s) remnant is repositioned with intact vascular supply to a plane superficial to the infrahyoid strap muscles and immediately under the skin incision. This technique called Subtotal Parathyroidectomy and Remnant Relocation (SPARE) retains all the metabolic advantages of the conventional operation with the added advantage of easier identification of a recurrent hyperplastic remnant if re-exploration becomes necessary...
October 23, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28982382/correction-to-functional-and-quality-of-life-outcomes-after-partial-glossectomy-a-multi-institutional-longitudinal-study-of-the-head-and-neck-research-network
#8
Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R Harris, Daniel A O'Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Heikki Irjala, Tero Soukka, Juhani Laine
No abstract text is available yet for this article.
October 5, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28978360/topical-propranolol-improves-epistaxis-in-patients-with-hereditary-hemorrhagic-telangiectasia-a-preliminary-report
#9
Meir Mei-Zahav, Hannah Blau, Elchanan Bruckheimer, Eyal Zur, Neta Goldschmidt
BACKGROUND: Severe epistaxis is often difficult to control in patients with hereditary hemorrhagic telangiectasia (HHT). Propranolol has been shown to have antiangiogenic properties in vitro and in vivo and is commonly used to treat hemangiomas. We present our experience with topical nasal propranolol for the treatment of moderate to severe epistaxis in patients with HHT. METHODS: Retrospective case series. Six patients with HHT were treated with 0.5 cm(3) of 1...
October 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28927445/paradigm-shift-in-head-and-neck-oncology-patient-management
#10
LETTER
Chiquit van Linden van den Heuvell, Florence van Zuuren, Mary Wells, Geert van der Laan, Harry Reintsema
OBJECTIVE: This article describes a paradigm shift in what is considered to be good care for patients living with and after (head and neck) cancer. HNO patients often experience severe and difficult physical and psychosocial problems due to the nature and location of the disease. Many disciplines are involved in their treatment, so their voice is only one amongst many others in the decision making process. For this patient group it seems complicated to put the concept of Shared Decision Making into practice...
September 19, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28870248/functional-and-quality-of-life-outcomes-after-partial-glossectomy-a-multi-institutional-longitudinal-study-of-the-head-and-neck-research-network
#11
Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R Harris, Daniel A O'Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Heikki Irjala, Tero Soukka, Juhani Laine
BACKGROUND: While aggressive treatment for oral cancer may optimize survival, decrements in speech and swallowing function and quality of life often result. This exploratory study investigated how patients recover their communicative function, swallowing ability, and quality of life after primary surgery [with or without adjuvant (chemo)radiation therapy] for tongue cancer over the course of the first year post-operation. METHODS: Patients treated for oral cancer at three institutions (University of Alberta Hospital, Mount Sinai Beth Israel Medical Center, and Turku University Hospital) were administered patient-reported outcomes assessing speech [Speech Handicap Index (SHI)], swallowing [(M...
September 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28851430/evolution-of-gender-representation-among-canadian-otl-hns-residents-a-27-year-analysis
#12
Sarah Chorfi, Joseph S Schwartz, Neil Verma, Meredith Young, Lawrence Joseph, Lily H P Nguyen
BACKGROUND: The proportion of females enrolling into medical schools has been growing steadily. However, the representation of female residents among individual specialties has shown considerable variation. The purpose of this study was to compare the trends of gender representation in Otolaryngology - Head and Neck Surgery (OTL-HNS) residency programs with other specialty training programs in Canada. In order to contextualize these findings, a second phase of analysis examined the success rate of applicants of different genders to OTL-HNS residency programs...
August 29, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28830509/peri-operative-factors-predisposing-to-pharyngocutaneous-fistula-after-total-laryngectomy-analysis-of-a-large-multi-institutional-patient-cohort
#13
Nicole L Lebo, Lisa Caulley, Hussain Alsaffar, Martin J Corsten, Stephanie Johnson-Obaseki
BACKGROUND: Pharyngocutaneous fistula (PCF) is a problematic complication following total laryngectomy. Disagreement remains regarding predisposing factors. This study examines perioperative factors predicting PCF following total laryngectomy using a large multicenter data registry. METHODS: Retrospective cohort analysis was performed using patients undergoing total laryngectomy in the ACS-NSQIP database for 2006-2014. Sub-analysis was performed based on reconstruction type...
August 23, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28830539/endoscopically-assisted-transmastoid-approach-to-the-geniculate-ganglion-and-labyrinthine-facial-nerve
#14
Nicholas Jufas, Manohar Bance
BACKGROUND: Endoscopic transcanal approaches to the facial nerve allow excellent exposure of the tympanic facial nerve. This approach becomes limited when access is required to the more proximal geniculate ganglion and labyrinthine portion of the facial nerve. The aim of this report was to determine the feasibility of a transmastoid endoscopically assisted approach to the geniculate ganglion and labyrinthine facial nerve. This is an endoscopic cadaveric dissection and video review at a university anatomical laboratory...
August 22, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28818106/morphoproteomics-e6-e7-in-situ-hybridization-and-biomedical-analytics-define-the-etiopathogenesis-of-hpv-associated-oropharyngeal-carcinoma-and-provide-targeted-therapeutic-options
#15
Robert E Brown, Syed Naqvi, Mary F McGuire, Jamie Buryanek, Ron J Karni
BACKGROUND: Human papillomavirus (HPV) has been identified as an etiopathogenetic factor in oropharyngeal squamous cell carcinoma. The HPV E6 and E7 oncogenes are instrumental in promoting proliferation and blocking differentiation leading to tumorigenesis. Although surgical intervention can remove such tumors, the potential for an etiologic field effect with recurrent disease is real. A downstream effector of E7 oncoprotein, enhancer of zeste homolog 2 (EZH2), is known to promote proliferation and to pose a block in differentiation and in turn, could lead to HPV-induced malignant transformation...
August 17, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28693609/otolaryngology-exposure-in-a-longitudinal-integrated-clerkship-setting
#16
Grace Margaret Scott, Corliss Ann Elizabeth Best, Damian Christopher Micomonaco
BACKGROUND: Although 20-40% of primary care complaints are Otolaryngology-Head and Neck Surgery (OtoHNS) related, little emphasis is placed on OtoHNS instruction at the undergraduate medical education level. An OtoHNS clerkship rotation is not required at most Canadian medical schools. Furthermore, at institutions offering an OtoHNS rotation, less than 20% of students are able to complete a placement. Given that a large percentage of medical students in Canada will pursue primary care as a career, there remains a gap in providing OtoHNS clinical training...
July 10, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28662721/rheopheresis-in-treatment-of-idiopathic-sensorineural-sudden-hearing-loss
#17
Milan Kostal, Jakub Drsata, Milan Bláha, Miriam Lánská, Viktor Chrobok
BACKROUND: Only few therapeutic options exist for patients with refractory sudden idiopathic sensorineural hearing loss (SISHL). Little is known about the efficacy of second-line therapies. Rheopheresis seems to be an effective therapeutic possibility. METHODS: Between 2012 and 2015, 106 patients with SISHL were enrolled in the study, of whom 52 were refractory to initial treatment. As salvage therapy, these patients were offered either 3 sessions of rheopheresis (33 pts) or intratympanic steroid treatment through MicroWick application (19 pts)...
June 29, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28645310/pth-monitoring-after-total-parathyroidectomy-with-forearm-auto-transplantation-potential-for-spuriously-high-levels-from-grafted-forearm
#18
Diana Khalil, Paul D Kerr
BACKGROUND: We have identified a cause of falsely elevated parathyroid hormone (PTH) levels after total parathyroidectomy with forearm auto-transplantation (TPT-ATx). Our cases highlight the need to draw PTH samples remotely, away from forearm graft sites, to ensure accurate levels. CASE PRESENTATIONS: We report on four patients who were referred to our surgical team at an academic tertiary care center for what was perceived to be recurrent hyperparathyroidism 2-5 years following total parathyroidectomy with auto-transplantation...
June 23, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28623942/the-palisade-cartilage-tympanoplasty-technique-a-systematic-review-and-meta-analysis
#19
REVIEW
Caroline C Jeffery, Cameron Shillington, Colin Andrews, Allan Ho
BACKGROUND: Tympanoplasty is a common procedure performed by Otolaryngologists. Many types of autologous grafts have been used with variations of techniques with varying results. This is the first systematic review of the literature and meta-analysis with the aim to evaluate the effectiveness of one of the techniques which is gaining popularity, the palisade cartilage tympanoplasty. PubMed, EMBASE, and Cochrane databases were searched for "palisade", "cartilage", "tympanoplasty", "perforation" and their synonyms...
June 17, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28619119/transmission-of-a-novel-sonotubometry-acoustic-click-stimulus-in-healthy-and-patulous-eustachian-tube-subjects-a-retrospective-case-control-study
#20
Justin M Pyne, Yaw Amoako-Tuffour, Guy Earle, Graham McIntyre, Michael B Butler, Manohar Bance
BACKGROUND: Eustachian tube (ET) dysfunction can be very difficult to diagnose accurately. Our aim is to determine whether a newly developed sonotubometric test using clicks can reliably detect ET opening during swallowing in normal ET subjects, and patulous ET (PET) in subjects with ET dysfunction. METHODS: Sixteen subjects (19 normal ET ears and 6 PET ears) were individually placed in a sound-isolated audiometry booth and subjected to a 1000Hz click train stimulus, played through the nose...
June 15, 2017: Journal of Otolaryngology—Head & Neck Surgery
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