journal
MENU ▼
Read by QxMD icon Read
search

Annals of Applied Statistics

journal
https://www.readbyqxmd.com/read/29308102/doubly-robust-estimation-of-optimal-treatment-regimes-for-survival-data-with-application-to-an-hiv-aids-study
#1
Runchao Jiang, Wenbin Lu, Rui Song, Michael G Hudgens, Sonia Naprvavnik
In many biomedical settings, assigning every patient the same treatment may not be optimal due to patient heterogeneity. Individualized treatment regimes have the potential to dramatically improve clinical outcomes. When the primary outcome is censored survival time, a main interest is to find optimal treatment regimes that maximize the survival probability of patients. Since the survival curve is a function of time, it is important to balance short-term and long-term benefit when assigning treatments. In this paper, we propose a doubly robust approach to estimate optimal treatment regimes that optimize a user specified function of the survival curve, including the restricted mean survival time and the median survival time...
September 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/29152032/latent-class-modeling-using-matrix-covariates-with-application-to-identifying-early-placebo-responders-based-on-eeg-signals
#2
Bei Jiang, Eva Petkova, Thaddeus Tarpey, R Todd Ogden
Latent class models are widely used to identify unobserved subgroups (i.e., latent classes) based upon one or more manifest variables. The probability of belonging to each subgroup is typically modeled as a function of a set of measured covariates. In this paper, we extend existing latent class models to incorporate matrix covariates. This research is motivated by a randomized placebo-controlled depression clinical trial. One study goal is to identify a subgroup of subjects who experience symptoms improvement early on during antidepressant treatment, which is considered to be an indication of a placebo rather than a true pharmacological response...
September 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/29081874/testing-high-dimensional-covariance-matrices-with-application-to-detecting-schizophrenia-risk-genes
#3
Lingxue Zhu, Jing Lei, Bernie Devlin, Kathryn Roeder
Scientists routinely compare gene expression levels in cases versus controls in part to determine genes associated with a disease. Similarly, detecting case-control differences in co-expression among genes can be critical to understanding complex human diseases; however statistical methods have been limited by the high dimensional nature of this problem. In this paper, we construct a sparse-Leading-Eigenvalue-Driven (sLED) test for comparing two high-dimensional covariance matrices. By focusing on the spectrum of the differential matrix, sLED provides a novel perspective that accommodates what we assume to be common, namely sparse and weak signals in gene expression data, and it is closely related with Sparse Principal Component Analysis...
September 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/29081873/dynamic-prediction-for-multiple-repeated-measures-and-event-time-data-an-application-to-parkinson-s-disease
#4
Jue Wang, Sheng Luo, Liang Li
In many clinical trials studying neurodegenerative diseases such as Parkinson's disease (PD), multiple longitudinal outcomes are collected to fully explore the multidimensional impairment caused by this disease. If the outcomes deteriorate rapidly, patients may reach a level of functional disability sufficient to initiate levodopa therapy for ameliorating disease symptoms. An accurate prediction of the time to functional disability is helpful for clinicians to monitor patients' disease progression and make informative medical decisions...
September 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/29250210/quantification-of-multiple-tumor-clones-using-gene-array-and-sequencing-data
#5
Yichen Cheng, James Y Dai, Thomas G Paulson, Xiaoyu Wang, Xiaohong Li, Brian J Reid, Charles Kooperberg
Cancer development is driven by genomic alterations, including copy number aberrations. The detection of copy number aberrations in tumor cells is often complicated by possible contamination of normal stromal cells in tumor samples and intratumor heterogeneity, namely the presence of multiple clones of tumor cells. In order to correctly quantify copy number aberrations, it is critical to successfully de-convolute the complex structure of the genetic information from tumor samples. In this article, we propose a general Bayesian method for estimating copy number aberrations when there are normal cells and potentially more than one tumor clones...
June 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28989557/allele-specific-copy-number-estimation-by-whole-exome-sequencing
#6
Hao Chen, Yuchao Jiang, Kara N Maxwell, Katherine L Nathanson, Nancy Zhang
Whole exome sequencing is currently a technology of choice in large-scale cancer genomics studies, where the priority is to identify cancer-associated variants in coding regions. We describe a method for estimating allele-specific copy number using whole exome sequencing data from tumor and matched normal.
June 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28959370/integrative-sparse-k-means-with-overlapping-group-lasso-in-genomic-applications-for-disease-subtype-discovery
#7
Zhiguang Huo, George Tseng
Cancer subtypes discovery is the first step to deliver personalized medicine to cancer patients. With the accumulation of massive multi-level omics datasets and established biological knowledge databases, omics data integration with incorporation of rich existing biological knowledge is essential for deciphering a biological mechanism behind the complex diseases. In this manuscript, we propose an integrative sparse K-means (is-K means) approach to discover disease subtypes with the guidance of prior biological knowledge via sparse overlapping group lasso...
June 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28943991/improving-efficiency-in-biomarker-incremental-value-evaluation-under-two-phase-designs
#8
Yingye Zheng, Marshall Brown, Anna Lok, Tianxi Cai
Cost-effective yet efficient designs are critical to the success of biomarker evaluation research. Two-phase sampling designs, under which expensive markers are only measured on a subsample of cases and non-cases within a prospective cohort, are useful in novel biomarker studies for preserving study samples and minimizing cost of biomarker assaying. Statistical methods for quantifying the predictiveness of biomarkers under two-phase studies have been proposed (Cai and Zheng, 2012; Liu, Cai and Zheng, 2012)...
June 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/29276550/inference-for-social-network-models-from-egocentrically-sampled-data-with-application-to-understanding-persistent-racial-disparities-in-hiv-prevalence-in-the-us
#9
Pavel N Krivitsky, Martina Morris
Egocentric network sampling observes the network of interest from the point of view of a set of sampled actors, who provide information about themselves and anonymized information on their network neighbors. In survey research, this is often the most practical, and sometimes the only, way to observe certain classes of networks, with the sexual networks that underlie HIV transmission being the archetypal case. Although methods exist for recovering some descriptive network features, there is no rigorous and practical statistical foundation for estimation and inference for network models from such data...
March 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28979611/forecasting-seasonal-influenza-with-a-state-space-sir-model
#10
Dave Osthus, Kyle S Hickmann, Petruţa C Caragea, Dave Higdon, Sara Y Del Valle
Seasonal influenza is a serious public health and societal problem due to its consequences resulting from absenteeism, hospitalizations, and deaths. The overall burden of influenza is captured by the Centers for Disease Control and Prevention's influenza-like illness network, which provides invaluable information about the current incidence. This information is used to provide decision support regarding prevention and response efforts. Despite the relatively rich surveillance data and the recurrent nature of seasonal influenza, forecasting the timing and intensity of seasonal influenza in the U...
March 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28572869/covariate-adaptive-clustering-of-exposures-for-air-pollution-epidemiology-cohorts
#11
Joshua P Keller, Mathias Drton, Timothy Larson, Joel D Kaufman, Dale P Sandler, Adam A Szpiro
Cohort studies in air pollution epidemiology aim to establish associations between health outcomes and air pollution exposures. Statistical analysis of such associations is complicated by the multivariate nature of the pollutant exposure data as well as the spatial misalignment that arises from the fact that exposure data are collected at regulatory monitoring network locations distinct from cohort locations. We present a novel clustering approach for addressing this challenge. Specifically, we present a method that uses geographic covariate information to cluster multi-pollutant observations and predict cluster membership at cohort locations...
March 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28408966/gene-network-reconstruction-using-global-local-shrinkage-priors
#12
Gwenaël G R Leday, Mathisca C M de Gunst, Gino B Kpogbezan, Aad W van der Vaart, Wessel N van Wieringen, Mark A van de Wiel
Reconstructing a gene network from high-throughput molecular data is an important but challenging task, as the number of parameters to estimate easily is much larger than the sample size. A conventional remedy is to regularize or penalize the model likelihood. In network models, this is often done locally in the neighbourhood of each node or gene. However, estimation of the many regularization parameters is often difficult and can result in large statistical uncertainties. In this paper we propose to combine local regularization with global shrinkage of the regularization parameters to borrow strength between genes and improve inference...
March 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/29218072/spatial-multiresolution-analysis-of-the-effect-of-pm2-5-on-birth-weights
#13
Joseph Antonelli, Joel Schwartz, Itai Kloog, Brent A Coull
Fine particulate matter (PM2.5) measured at a given location is a mix of pollution generated locally and pollution traveling long distances in the atmosphere. Therefore, the identification of spatial scales associated with health effects can inform on pollution sources responsible for these effects, resulting in more targeted regulatory policy. Recently, prediction methods that yield high-resolution spatial estimates of PM2.5 exposures allow one to evaluate such scale-specific associations. We propose a two-dimensional wavelet decomposition that alleviates restrictive assumptions required for standard wavelet decompositions...
2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28367256/investigating-differences-in-brain-functional-networks-using-hierarchical-covariate-adjusted-independent-component-analysis
#14
Ran Shi, Ying Guo
Human brains perform tasks via complex functional networks consisting of separated brain regions. A popular approach to characterize brain functional networks in fMRI studies is independent component analysis (ICA), which is a powerful method to reconstruct latent source signals from their linear mixtures. In many fMRI studies, an important goal is to investigate how brain functional networks change according to specific clinical and demographic variabilities. Existing ICA methods, however, cannot directly incorporate covariate effects in ICA decomposition...
December 2016: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28280520/linking-lung-airway-structure-to-pulmonary-function-via-composite-bridge-regression
#15
Kun Chen, Eric A Hoffman, Indu Seetharaman, Feiran Jiao, Ching-Long Lin, Kung-Sik Chan
The human lung airway is a complex inverted tree-like structure. Detailed airway measurements can be extracted from MDCT-scanned lung images, such as segmental wall thickness, airway diameter, parent-child branch angles, etc. The wealth of lung airway data provides a unique opportunity for advancing our understanding of the fundamental structure-function relationships within the lung. An important problem is to construct and identify important lung airway features in normal subjects and connect these to standardized pulmonary function test results such as FEV1%...
December 2016: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28090239/the-screening-and-ranking-algorithm-for-change-points-detection-in-multiple-samples
#16
Chi Song, Xiaoyi Min, Heping Zhang
The chromosome copy number variation (CNV) is the deviation of genomic regions from their normal copy number states, which may associate with many human diseases. Current genetic studies usually collect hundreds to thousands of samples to study the association between CNV and diseases. CNVs can be called by detecting the change-points in mean for sequences of array-based intensity measurements. Although multiple samples are of interest, the majority of the available CNV calling methods are single sample based...
December 2016: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28580047/quantifying-the-spatial-inequality-and-temporal-trends-in-maternal-smoking-rates-in-glasgow
#17
Duncan Lee, Andrew Lawson
Maternal smoking is well known to adversely affect birth outcomes, and there is considerable spatial variation in the rates of maternal smoking in the city of Glasgow, Scotland. This spatial variation is a partial driver of health inequalities between rich and poor communities, and it is of interest to determine the extent to which these inequalities have changed over time. Therefore in this paper we develop a Bayesian hierarchical model for estimating the spatio-temporal pattern in smoking incidence across Glasgow between 2000 and 2013, which can identify the changing geographical extent of clusters of areas exhibiting elevated maternal smoking incidences that partially drive health inequalities...
September 28, 2016: Annals of Applied Statistics
https://www.readbyqxmd.com/read/29057027/discussion-of-fiber-direction-estimation-in-diffusion-mri
#18
Jian Kang, Lexin Li
No abstract text is available yet for this article.
September 2016: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28804529/rejoinder-fiber-direction-estimation-smoothing-and-tracking-in-diffusion-mri
#19
COMMENT
Raymond K W Wong, Thomas C M Lee, Debashis Paul, Jie Peng
No abstract text is available yet for this article.
September 2016: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28638497/fiber-direction-estimation-smoothing-and-tracking-in-diffusion-mri
#20
Raymond K W Wong, Thomas C M Lee, Debashis Paul, Jie Peng
Diffusion magnetic resonance imaging is an imaging technology designed to probe anatomical architectures of biological samples in an in vivo and noninvasive manner through measuring water diffusion. The contribution of this paper is threefold. First, it proposes a new method to identify and estimate multiple diffusion directions within a voxel through a new and identifiable parametrization of the widely used multi-tensor model. Unlike many existing methods, this method focuses on the estimation of diffusion directions rather than the diffusion tensors...
September 2016: Annals of Applied Statistics
journal
journal
42077
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"