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Tuberculosis and Respiratory Diseases

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https://www.readbyqxmd.com/read/28747967/systemic-white-blood-cell-count-as-a-biomarker-for-chronic-obstructive-pulmonary-disease-utility-and-limitations
#1
EDITORIAL
Tae-Hyung Kim
No abstract text is available yet for this article.
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747966/pharmacotherapy-for-acute-respiratory-distress-syndrome-limited-success-to-date
#2
EDITORIAL
Kyeongman Jeon
No abstract text is available yet for this article.
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747965/systemic-white-blood-cell-count-as-a-biomarker-associated-with-severity-of-chronic-obstructive-lung-disease
#3
Hyeon-Kyoung Koo, Hyung Koo Kang, Pamela Song, Hye Kyeong Park, Sung-Soon Lee, Hoon Jung
BACKGROUND: Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity of COPD, independent of other inflammatory conditions, such as metabolic syndrome. METHODS: The WBC counts were compared between 1227 COPD patients and 8679 non-COPD adults older than 40. The relationships between the WBC count, lung function, and symptoms score in COPD patients, were determined, using general linear regression analyses...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747964/effect-of-preadmission-metformin-use-on-clinical-outcome-of-acute-respiratory-distress-syndrome-among-critically-ill-patients-with-diabetes
#4
Yong Suk Jo, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee
BACKGROUND: Acute respiratory distress syndrome (ARDS) is related to high mortality and morbidity. There are no proven therapeutic measures however, to improve the clinical course of ARDS, except using low tidal volume ventilation. Metformin is known to have pleiotropic effects including anti-inflammatory activity. We hypothesized that pre-admission metformin might alter the progress of ARDS among intensive care unit (ICU) patients with diabetes mellitus (DM). METHODS: We performed a retrospective cohort study from January 1, 2005, to April 30, 2005 of patients who were admitted to the medical ICU at Seoul National University Hospital because of ARDS, and reviewed ARDS patients with DM...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747963/review-of-sarcoidosis-in-a-province-of-south-korea-from-1996-to-2014
#5
Min-Seok Kim, Cheol-Kyu Park, Hong-Joon Shin, Hyeong-Won Seo, Jinsun Chang, Seong Ahn, Tae-Ok Kim, Jung-Hwan Lim, In-Jae Oh, Yong-Soo Kwon, Yu-Il Kim, Sung-Chul Lim, Young-Chul Kim
BACKGROUND: Since the introduction of endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) of mediastinal lymph nodes, the incidence of histopathologically-confirmed sarcoidosis has increased. METHODS: The electronic medical records of Chonnam National University (CNU) Hospital and CNU Hwasun Hospital (CNUHH) were searched for confirmed cases of sarcoidosis diagnosed between 1996 and 2014. Cases were selected using a combination of clinical, radiological, and pathological evidence...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747962/factors-related-to-the-diagnostic-yield-of-flexible-bronchoscopy-without-guidance-in-bronchoscopically-invisible-peripheral-lung-lesions
#6
Hye Seon Kang, Jick Hwan Ha, Hyeon Hui Kang, Chang Dong Yeo, Chin Kook Rhee, Sung Kyoung Kim, Hwa Sik Moon, Sang Haak Lee
BACKGROUND: We aimed to analyze the factors predicting the diagnostic performance of flexible bronchoscopy without guidance in peripheral lung lesions that are endoscopically invisible. METHODS: This was a retrospective study conducted in St. Paul's Hospital, The Catholic University of Korea, between January 2007 and March 2013. We included all patients who received bronchoscopy during this period. The analyzed variables were age, sex, the etiology of the lesion, lesion size, distance from the pleura, and presence of the bronchus sign...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747961/determinants-of-nicotine-dependence-in-chronic-obstructive-pulmonary-disease
#7
Yun Su Sim, Jin Hwa Lee, Ki Uk Kim, Seung Won Ra, Hye Yun Park, Chang-Hoon Lee, Deog Kyeom Kim, Kyeong-Cheol Shin, Sang Haak Lee, Hun Gyu Hwang, Joong Hyun Ahn, Yong Bum Park, Yu-Il Kim, Kwang Ha Yoo, Ina Jeong, Yeon-Mok Oh, Sang-Do Lee
BACKGROUND: Smoking cessation is the most powerful intervention to modify progress of chronic obstructive pulmonary disease (COPD), and nicotine dependence is one of the most important determinants of success or failure in smoking cessation. We evaluated nicotine dependence status and investigated factors associated with moderate to high nicotine dependence in patients with COPD. METHODS: We included 53 current smokers with COPD in the Korean Obstructive Lung Disease II cohort enrolled between January 2014 and March 2016...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747960/frequency-and-type-of-disputed-rpob-mutations-in-mycobacterium-tuberculosis-isolates-from-south-korea
#8
Kyung-Wook Jo, Soyeon Lee, Mi Ran Kang, Heungsup Sung, Mi-Na Kim, Tae Sun Shim
BACKGROUND: A disputed rpoB mutation is a specific type of rpoB mutation that can cause low-level resistances to rifampin (RIF). Here, we aimed to assess the frequency and types of disputed rpoB mutations in Mycobacterium tuberculosis isolates from South Korea. METHODS: Between August 2009 and December 2015, 130 patients exhibited RIF resistance on the MTBDRplus assay at Asan Medical Center. Among these cases, we identified the strains with disputed rpoB mutation by rpoB sequencing analysis, as well as among the M...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747959/effect-of-prophylactic-use-of-silymarin-on-anti-tuberculosis-drugs-induced-hepatotoxicity
#9
Eunyoung Heo, Deog Kyeom Kim, So Hee Oh, Jung-Kyu Lee, Ju-Hee Park, Hee Soon Chung
BACKGROUND: The first line of anti-tuberculosis (TB) drugs are the most effective standard of drugs for TB. However, the use of these drugs is associated with hepatotoxicity. Silymarin has protective effects against hepatotoxicity of anti-TB drugs in animal models. This study aims to investigate the protective effect of silymarin on hepatotoxicity caused by anti-TB drugs. METHODS: This is a prospective, randomized, double-blind and placebo-controlled study. Patients were eligible if they were 20 years of age or order and started the first-line anti-tuberculosis drugs...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747958/the-role-of-n-acetyl-transferases-on-isoniazid-resistance-from-mycobacterium-tuberculosis-and-human-an-in-silico-approach
#10
Ameeruddin Nusrath Unissa, Swathi Sukumar, Luke Elizabeth Hanna
BACKGROUND: N-acetyl transferase (NAT) inactivates the pro-drug isoniazid (INH) to N-acetyl INH through a process of acetylation, and confers low-level resistance to INH in Mycobacterium tuberculosis (MTB). Similar to NAT of MTB, NAT2 in humans performs the same function of acetylation. Rapid acetylators, may not respond to INH treatment efficiently, and could be a potential risk factor, for the development of INH resistance in humans. METHODS: To understand the contribution of NAT of MTB and NAT2 of humans in developing INH resistance using in silico approaches, in this study, the wild type (WT) and mutant (MT)-NATs of MTB, and humans, were modeled and docked, with substrates and product (acetyl CoA, INH, and acetyl INH)...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747957/acn9-regulates-the-inflammatory-responses-in-human-bronchial-epithelial-cells
#11
Jae Hoon Jeong, Jeeyoung Kim, Jeongwoon Kim, Hye-Ryeon Heo, Jin Seon Jeong, Young-Joon Ryu, Yoonki Hong, Seon-Sook Han, Seok-Ho Hong, Seung-Joon Lee, Woo Jin Kim
BACKGROUND: Airway epithelial cells are the first line of defense, against pathogens and environmental pollutants, in the lungs. Cellular stress by cadmium (Cd), resulting in airway inflammation, is assumed to be directly involved in tissue injury, linked to the development of lung cancer, and chronic obstructive pulmonary disease (COPD). We had earlier shown that ACN9 (chromosome 7q21), is a potential candidate gene for COPD, and identified significant interaction with smoking, based on genetic studies...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747956/evaluation-of-appropriate-management-of-chronic-obstructive-pulmonary-disease-in-korea-based-on-health-insurance-review-and-assessment-service-hira-claims
#12
REVIEW
Sang Mi Chung, Sung Yong Lee
Chronic obstructive pulmonary disease (COPD) is an ambulatory care-sensitive condition, and effective treatment of outpatients can prevent worsening of the illness and hospitalization. Current COPD guidelines provide appropriate guidance for the diagnosis and treatment of patients with COPD. In fact, it has been shown that when appropriate guidance and treatment are performed, the morbidity and mortality rates of COPD patients are reduced. However, there is a gap between the clinical guidelines and the actual clinical treatment...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747955/summary-of-the-chronic-obstructive-pulmonary-disease-clinical-practice-guideline-revised-in-2014-by-the-korean-academy-of-tuberculosis-and-respiratory-disease
#13
REVIEW
Hyoung Kyu Yoon, Yong-Bum Park, Chin Kook Rhee, Jin Hwa Lee, Yeon-Mok Oh
Chronic obstructive pulmonary disease (COPD) results in high morbidity and mortality among patients both domestically and globally. The Korean clinical practice guideline for COPD was revised in 2014. It was drafted by the members of the Korean Academy of Tuberculosis and Respiratory Diseases, as well as participating members of the Health Insurance Review and Assessment Service, Korean Physicians' Association, and Korea Respiration Trouble Association. This revised guideline covers a wide range of topics, including the epidemiology, diagnosis, assessment, monitoring, management, exacerbation, and comorbidities of COPD in Korea...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747954/recent-trends-in-the-prevalence-of-chronic-obstructive-pulmonary-disease-in-korea
#14
REVIEW
Yong Il Hwang, Yong Bum Park, Kwang Ha Yoo
Chronic obstructive pulmonary disease (COPD) had been considered the only major disease that is continuing to increase in prevalence. There were a few studies about the change of the prevalence of COPD, which showed the prevalence of COPD did not increase. In this review, we report on the trends in the prevalence of COPD in Korea using the data from Korea National Health and Nutrition Examination Survey (KNHANES). The prevalence of COPD in 2015 was 13.4% (male, 21.6%; female, 5.8%). The prevalence of COPD did not change much, which ranged from 13...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747953/current-epidemiological-data-on-asthma-management-in-south-korea-from-qualitative-assessment-of-asthma-management-by-health-insurance-review-and-assessment-service-hira
#15
REVIEW
So Ri Kim, Yong Chul Lee, Myung Ju Sung, Hye Won Bae
Since 2015, the Health Insurance Review and Assessment Service (HIRA) has performed annual qualitative assessments of asthma management provided by all medical institutions that care for asthma patients in Korea. According to the third report of qualitative assessment of asthma management in 2017, the assessment appears to have contributed to improving the quality of asthma care provided by medical institutions, especially primary clinics. However, there is still a gap between the ideal goals of asthma management and actual health care policies/regulations in real clinical settings, which leads to the state of standstill with respect to the quality of asthma management despite considerable efforts such as the qualitative assessment of asthma management by national agencies such as the HIRA...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28416962/cutaneous-leukocytoclastic-vasculitis-with-gastrointestinal-involvement-after-anti-tuberculosis-treatment
#16
Sangwoo Shim, Chi Young Jung
No abstract text is available yet for this article.
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28416961/predictive-factors-of-methicillin-resistant-staphylococcus-aureus-infection-in-elderly-patients-with-community-onset-pneumonia
#17
Hyeyoung Jwa, Jong Wook Beom, Jong Hoo Lee
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a severe and life-threatening disease in patients with community-onset (CO) pneumonia. However, the current guidelines lack specificity for a screening test for MRSA infection. METHODS: This study was retrospectively conducted in elderly patients aged ≥65 years, who had contracted CO-pneumonia during hospitalization at the Jeju National University Hospital, between January 2012 and December 2014...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28416960/medical-thoracoscopy-in-pleural-disease-experience-from-a-one-center-study
#18
Soo Jung Kim, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
BACKGROUND: Medical thoracoscopy (MT) is a minimally invasive, endoscopic procedure for exploration of the pleural cavity under conscious sedation and local anesthesia. MT has been performed at the Seoul National University Hospital since February 2014. This paper summarizes the findings and outcomes of MT cases at this hospital. METHODS: Patients who had undergone MT were enrolled in the study. MT was performed by pulmonologists, using both rigid and semi-rigid thoracoscopes...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28416959/predictive-factors-for-switched-egfr-tki-retreatment-in-patients-with-egfr-mutant-non-small-cell-lung-cancer
#19
Byoung Soo Kwon, Ji Hyun Park, Woo Sung Kim, Joon Seon Song, Chang-Min Choi, Jin Kyung Rho, Jae Cheol Lee
BACKGROUND: Third-generation tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKIs) have proved efficacious in treating non-small cell lung cancer (NSCLC) patients with acquired resistance resulting from the T790M mutation. However, since almost 50% patients with the acquired resistance do not harbor the T790M mutation, retreatment with first- or second-generation EGFR-TKIs may be a more viable therapeutic option. Here, we identified positive response predictors to retreatment, in patients who switched to a different EGFR-TKI, following initial treatment failure...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28416958/keratinization-of-lung-squamous-cell-carcinoma-is-associated-with-poor-clinical-outcome
#20
Hye Jung Park, Yoon-Jin Cha, Seong Han Kim, Arum Kim, Eun Young Kim, Yoon Soo Chang
BACKGROUND: Although the World Health Organization (WHO) classification of lung squamous cell carcinoma (SCC) was revised in 2015, its clinical implications for lung SCC subsets remain unclear. We investigated whether the morphologic characteristics of lung SCC, including keratinization, were associated with clinical parameters and clinical outcome of patients. METHODS: A total of 81 patients who underwent curative surgical resection of diagnosed lung SCC, were enrolled in this study...
April 2017: Tuberculosis and Respiratory Diseases
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