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Tuberculosis and Respiratory Diseases

Da Hye Moon, Sung Ok Kwon, Woo Jin Kim, Yoonki Hong
BACKGROUND: The development of lung cancer results from the interaction between genetic mutations and dynamic epigenetic alterations, although the exact mechanisms are not completely understood. Changes in DNA methylation may be a promising biomarker for early detection and prognosis of lung cancer. We evaluated the serial changes in genome-wide DNA methylation patterns in blood samples of lung cancer patients. METHODS: Blood samples were obtained for three consecutive years from three patients (2 years before, 1 year before, and after lung cancer detection) and from three control subjects (without lung cancer)...
September 28, 2018: Tuberculosis and Respiratory Diseases
Changhwan Kim, Younhee Kim, Dong Wook Yang, Chin Kook Rhee, Sung Kyoung Kim, Yong Il Hwang, Yong Bum Park, Young Mok Lee, Seonglim Jin, Jinkyeong Park, Cho Rom Hahm, Chang Han Park, So Yeon Park, Cheol Kweon Jung, Yu Il Kim, Sang Haak Lee, Hyoung Kyu Yoon, Jin Hwa Lee, Seong Yong Lim, Kwang Ha Yoo
BACKGROUND: Understanding the burden of disease is important to establish cost-effective treatment strategies and to allocate healthcare resources appropriately. However, little reliable information is available regarding the overall economic burden imposed by chronic obstructive pulmonary disease (COPD) in Korea. METHODS: This study is a multicenter observational research on the COPD burden in Korea. Total COPD costs were comprised of three categories: direct medical, direct non-medical, and indirect costs...
September 28, 2018: Tuberculosis and Respiratory Diseases
Sangyoon Lee, Ji Young Ryu, Dae Hwan Kim
BACKGROUND: Tuberculosis (TB) is the most important disease screened for upon patient history review during preimmigration medical examinations as performed in South Korea in prospective immigrants to certain Western countries. In 2007, the U.S. Centers for Disease Control and Prevention (CDC) changed the TB screening protocol from a smear-based test to the complete Culture and Directly Observed Therapy Tuberculosis Technical Instructions (CDOT TB TI) for reducing the incidence of TB in foreign-born immigrants...
September 28, 2018: Tuberculosis and Respiratory Diseases
Joo Hee Lee, Kyung Wook Jo, Tae Sun Shim
BACKGROUND: The purpose of this study was to analyze the relationship between the gene mutation patterns by the GenoType MTBDR plus (MTBDR plus ) assay and the phenotypic drug susceptibility test (pDST) results of isoniazid (INH) and prothionamide (Pto). METHODS: A total of 206 patients whose MTBDR plus assay results revealed katG or inhA mutations were enrolled in the study. The pDST results were compared to mutation patterns on the MTBDR plus assay. RESULTS: The katG and inhA mutations were identified in 68...
September 28, 2018: Tuberculosis and Respiratory Diseases
Jin Soo Park, Hyun Kuk Kim, Eun Young Kang, RyeonJin Cho, Yeon Mok Oh
BACKGROUND: A recent study reported that mesenchymal stem cells possess potential cellular therapeutic properties for treating patients with chronic obstructive pulmonary disease, which is characterized by emphysema. We examined the potential therapeutic effect of Wharton's Jelly-derived mesenchymal stem cells (WJMSCs), following pretreatment with pioglitazone, in lung regeneration mouse emphysema models. METHODS: We used two mouse emphysema models, an elastase-induced model and a cigarette smoke-induced model...
September 28, 2018: Tuberculosis and Respiratory Diseases
Hwan Il Kim, Sunghoon Park
Sepsis is a life-threatening condition caused by infection and represents a substantial global health burden. Recent epidemiological studies showed that sepsis mortality rates have decreased, but that the incidence has continued to increase. Although a mortality benefit from early-goal directed therapy (EGDT) in patients with severe sepsis or septic shock was reported in 2001, three subsequent multicenter randomized studies showed no benefits of EGDT versus usual care. Nonetheless, the early administration of antibiotics and intravenous fluids is considered crucial for the treatment of sepsis...
September 28, 2018: Tuberculosis and Respiratory Diseases
Doosoo Jeon
Nontuberculous mycobacteria (NTM) are ubiquitous organisms that are generally found not only in the natural environment but also in the human engineered environment, including water, soil, and dust. These organisms can form biofilms and can be readily aerosolized because they are hydrophobic owing to the presence of the lipid-rich outer membrane. Aerosolization and subsequent inhalation were the major route of NTM lung disease. Water distribution systems and household plumbing are ideal habit for NTM and the main transmission route from natural water to household...
September 28, 2018: Tuberculosis and Respiratory Diseases
Young Chul Kim, Young Joo Won
Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer-related deaths worldwide. Globally, there were an estimated 1.8 million new cases and 1.59 million deaths in 2012. In Korea, the incidence of lung cancer is increasing and 24,267 (47.6/100,000) patients with lung cancer were registered at the Korea Central Cancer Registry in 2015. Previous nationwide surveys of lung cancer were performed in 1998 by the Korean Academy of Tuberculosis and Respiratory Diseases and in 2007 by the Korean Association for Lung Cancer (KALC), but the studies faced difficulties in maintaining lung cancer registry because of limitations regarding the Private Information Protection Act...
September 28, 2018: Tuberculosis and Respiratory Diseases
You Sook Cho, Yeon Mok Oh
Inhaled corticosteroids (ICSs) have been widely used as a key medication for asthma control. However, ICSs have been known to cause respiratory infections, such as pneumonia and pulmonary tuberculosis. Consequently, a dilemma exists regarding recommendation of persistent lifetime use of ICSs to mild asthma patients. Short-acting β-agonists (SABAs) have also been widely used for symptom relief. However, SABAs have been reported to increase the risk of asthma-related death, though incidences have been very rare...
September 28, 2018: Tuberculosis and Respiratory Diseases
Jinyung Ju
This corrects the article on p. 132 in vol. 81, PMID: 29372631.
October 2018: Tuberculosis and Respiratory Diseases
Tai Joon An, Chin Kook Rhee, Ji Hye Kim, Young Rong Lee, Jin Young Chon, Chan Kwon Park, Hyoung Kyu Yoon
This corrects the article on p. 80 in vol. 81, PMID: 29332324.
October 2018: Tuberculosis and Respiratory Diseases
Hwa Sik Jung, Byung Ju Kang, Seung Won Ra, Kwang Won Seo, Yangjin Jegal, Jae Bum Jun, Jiwon Jung, Joseph Jeong, Hee Jeong Jeon, Jae Sung Ahn, Taehoon Lee, Jong Joon Ahn
This corrects the article on p. 358 in vol. 80, PMID: 28905531.
October 2018: Tuberculosis and Respiratory Diseases
Chin Kook Rhee
No abstract text is available yet for this article.
October 2018: Tuberculosis and Respiratory Diseases
Jae Seuk Park
BACKGROUND: The risk of tuberculosis (TB) infection among health care workers (HCWs) is higher than as noted among workers in the general population. The prevalence and risk factors of TB infection among HCWs were assessed in a tertiary hospital in South Korea, resulting in a conclusion of an intermediate TB burden within the country. METHODS: This cross-sectional study enrolled HCWs who underwent a QuantiFERON-TB Gold In-Tube (QFT-GIT) test to detect the presence of a latent TB infection (LTBI), in patients admitted to a tertiary hospital in South Korea in 2017...
October 2018: Tuberculosis and Respiratory Diseases
Jongmin Lee, Young Kyoon Kim, Ye Young Seo, Eun Kyoung Choi, Dong Soo Lee, Yeon Sil Kim, Sook Hee Hong, Jin Hyoung Kang, Kyo Young Lee, Jae Kil Park, Sook Whan Sung, Hyun Bin Kim, Mi Sun Park, Hyeon Woo Yim, Seung Joon Kim
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a standard procedure to evaluate suspicious lymph node involvement of lung cancer because computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography-CT (PET-CT) have limitations in their sensitivity and specificity. There are a number of benign causes of false positive lymph node such as anthracosis or anthracofibrosis, pneumoconiosis, old or active tuberculosis, interstitial lung disease, and other infectious conditions including pneumonia...
October 2018: Tuberculosis and Respiratory Diseases
Yong Bum Park, Chin Kook Rhee, Hyoung Kyu Yoon, Yeon Mok Oh, Seong Yong Lim, Jin Hwa Lee, Kwang Ha Yoo, Joong Hyun Ahn
Chronic obstructive pulmonary disease (COPD) results in high morbidity and mortality among patients nationally and globally. The Korean clinical practice guideline for COPD was revised in 2018. The guideline was drafted by the members of the Korean Academy of Tuberculosis and Respiratory Diseases as well as the participating members of the Health Insurance Review and Assessment Service, Korean Physicians' Association, and Korea Respiration Trouble Association. The revised guideline encompasses a wide range of topics, including the epidemiology, diagnosis, assessment, monitoring, management, exacerbation, and comorbidities of COPD in Korea...
October 2018: Tuberculosis and Respiratory Diseases
Hyonsoo Joo, Deokjae Han, Jae Ha Lee, Chin Kook Rhee
BACKGROUND: Roflumilast is the only approved oral phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease (COPD) in patients with chronic bronchitis and a history of frequent exacerbations. The purpose of this study was to examine the incidence of adverse effects associated with roflumilast treatment in a real-world setting. Further, we compared the incidence of adverse effects and the discontinuation rate among patients receiving different doses...
October 2018: Tuberculosis and Respiratory Diseases
Min Cheol Jeon, Ju Ock Kim, Sung Soo Jung, Hee Sun Park, Jeong Eun Lee, Jae Young Moon, Chae Uk Chung, Da Hyun Kang, Dong Il Park
BACKGROUND: We developed an additional laser guidance system to improve the efficacy and safety of conventional computed tomography (CT)-guided percutaneous transthoracic needle biopsy (PTNB), and we conducted this study to evaluate the efficacy and safety of our system. METHODS: We retrospectively analyzed the medical records of 244 patients who underwent CT-guided PTNB using our additional laser guidance system from July 1, 2015, to January 20, 2016. RESULTS: There were nine false-negative results among the 238 total cases...
October 2018: Tuberculosis and Respiratory Diseases
Eun Jin Kim, Chi Young Jung, Kyung Chan Kim
BACKGROUND: Bronchoalveolar lavage (BAL) is a necessary procedure for diagnosis of various lung diseases. High-flow nasal cannula (HFNC) oxygen delivery was recently introduced. This study aimed to investigate the safety and effectiveness of HFNC oxygen supply during BAL procedure in patients with acute respiratory failure (ARF). METHODS: Patients who underwent BAL while using HFNC at a partial pressure of oxygen in arterial blood/fraction of inspired oxygen (PaO₂/FiO₂; PF) ratio of 300 or below among patients who had been admitted from March 2013 to May 2017 were retrospectively investigated...
October 2018: Tuberculosis and Respiratory Diseases
Sunmi Ju, Tae Won Lee, Jung Wan Yoo, Seung Jun Lee, Yu Ji Cho, Yi Yeong Jeong, Jong Deog Lee, Ju Young Kim, Gi Dong Lee, Ho Cheol Kim
BACKGROUND: The aim of this study was to examine the influence of body mass index (BMI) on the development of acute kidney injury (AKI) in critically ill patients in intensive care unit (ICU). METHODS: Data of patients admitted to medical ICU from December 2011 to May 2014 were retrospectively analyzed. Patients were classified into three groups according to their BMI: underweight (<18.5 kg/m²), normal (18.5-24.9 kg/m²), and overweight (≥25 kg/m²). The incidence of AKI was compared among these groups and factors associated with the development of AKI were analyzed...
October 2018: Tuberculosis and Respiratory Diseases
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