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Tuberculosis and Respiratory Diseases

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https://www.readbyqxmd.com/read/29527846/smoking-cessation-strategies-targeting-specific-populations
#1
REVIEW
Eun Mi Chun
Quitting smoking helps smokers maintain their health and extend their lifespan by 10 or more years. Treatment strategies for smoking cessation should be tailored to individual smokers with special needs based on their specific circumstances. It is recommended that pregnant women adopt smoking cessation through counseling and behavioral interventions because the safety of medications has yet to be established. Counseling is the main strategy for smoking cessation in adolescents and nicotine replacement therapy can be used with caution in individuals with serious nicotine dependence...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527845/the-comparison-of-clinical-variables-in-two-classifications-gold-2017-combined-assessment-and-spirometric-stage-of-chronic-obstructive-pulmonary-disease
#2
Ipek Candemir, Pinar Ergun, Dicle Kaymaz, Filiz Tasdemir, Nurcan Egesel
BACKGROUND: There are limited number of studies that investigate clinical variables instead of chronic obstructive lung disease (COPD) management according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 classification. The aim of the study was to investigate whether there was a difference between GOLD 2017 classification and spirometric stage in clinical variables in patients with COPD. The data of 427 male patients with stable COPD were investigated retrospectively...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527842/different-pattern-of-chronic-obstructive-pulmonary-disease-assessment-test-score-between-chronic-bronchitis-and-non-chronic-bronchitis-patients
#3
Sang Hoon Yoo, Jae Ha Lee, Kwang Ha Yoo, Ki Suck Jung, Chin Kook Rhee
BACKGROUND: Chronic bronchitis (CB) is an important phenotype in chronic obstructive pulmonary disease (COPD). The purpose of this study is to evaluate different pattern of COPD assessment test (CAT) score between CB and non-CB patients. METHODS: Patients were recruited from 45 centers in Korea, as part of the Korean COPD Subgroup Study cohort. CB was defined when sputum continued for at least 3 months. RESULTS: Total 958 patients with COPD were eligible for analysis...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527840/increased-risk-of-exacerbation-in-asthma-predominant-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome
#4
Jisoo Park, Eun Kyung Kim, Mi Ae Kim, Tae Hyung Kim, Jung Hyun Chang, Yon Ju Ryu, Sei Won Lee, Yeon Mok Oh, Suk Joong Yong, Won Il Choi, Kwang Ha Yoo, Ji Hyun Lee
BACKGROUND: Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. METHODS: A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527839/serial-changes-in-mannose-binding-lectin-in-patients-with-sepsis
#5
Jin Won Huh, Kyuyoung Song, Hwa Jung Kim, Jung Sun Yum, Sang Bum Hong, Chae Man Lim, Younsuck Koh
BACKGROUND: Mannose-binding lectin (MBL) deficiency leads to increased susceptibility to infection. We investigated whether serial changes in MBL levels are associated with the prognosis of patients diagnosed with septic shock, and correlated with cytokine levels. METHODS: We enrolled 131 patients with septic shock in the study. We analyzed the serum samples for MBL and cytokine levels at baseline and 7 days later. Samples on day 7 were available in 73 patients...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527838/tuberculosis-relief-belt-supporting-project-tuberculosis-patient-management-project-for-poverty-group
#6
Jae Kyoung Kim, Ina Jeong, Ji Yeon Lee, Jung Hyun Kim, Ah Yeon Han, So Yeon Kim, Joon Sung Joh
BACKGROUND: The "Tuberculosis Relief Belt Supporting Project (Tuberculosis Patient Management Project for Poverty Groups)" is a national program for socioeconomically vulnerable tuberculosis (TB) patients. We sought to evaluate the clinical and socioeconomic characteristics of poverty-stricken TB patients, and determined the need for relief. METHODS: We examined in-patients with TB, who were supported by this project at the National Medical Center from 2014 to 2015...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527837/patterns-of-rpoc-mutations-in-drug-resistant-mycobacterium-tuberculosis-isolated-from-patients-in-south-korea
#7
Yeo Jun Yun, Jong Seok Lee, Je Chul Yoo, Eunjin Cho, Dahee Park, Yoon Hoh Kook, Keun Hwa Lee
BACKGROUND: Rifampicin (RFP) is one of the principal first-line drugs used in combination chemotherapies against Mycobacterium tuberculosis, and its use has greatly shortened the duration of chemotherapy for the successful treatment of drug-susceptible tuberculosis. Compensatory mutations have been identified in rpoC that restore the fitness of RFP-resistant M. tuberculosis strains with mutations in rpoB. To investigate rpoC mutation patterns, we analyzed 93 clinical M. tuberculosis isolates from patients in South Korea...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29589382/the-phosphodiesterase-4-inhibitor-roflumilast-protects-against-cigarette-smoke-extract-induced-mitophagy-dependent-cell-death-in-epithelial-cells
#8
Sun Young Kyung, Yu Jin Kim, Eun Suk Son, Sung Hwan Jeong, Jeong Woong Park
BACKGROUND: Recent studies show that mitophagy, the autophagy-dependent turnover of mitochondria, mediates pulmonary epithelial cell death in response to cigarette smoke extract (CSE) exposure and contributes to the development of emphysema in vivo during chronic cigarette smoke (CS) exposure, although the underlying mechanisms remain unclear. METHODS: In this study, we investigated the role of mitophagy in the regulation of CSE-exposed lung bronchial epithelial cell (Beas-2B) death...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29589381/continued-innovation-in-respiratory-care-the-importance-of-inhaler-devices
#9
REVIEW
Sinthia Zrinka Bosnic-Anticevich
When it comes to the use in inhalers in the management of chronic obstructive pulmonary diseases, there are many options, considerations and challenges, which health care professionals need to address. Considerations for prescribing and dispensing, administering and following up, education, and adherence; all of these factors impact on treatment success and all are intrinsically linked to the device selected. This review brings together relevant evidence, real-life data and practice tools to assist health care professionals in making decisions about the use of inhalers in the management of chronic obstructive pulmonary diseases...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527847/bibliometric-analysis-of-research-productivity-in-latent-tuberculosis-are-we-focusing-our-research-efforts-on-the-right-areas
#10
Sergio Alejandro Gómez Ochoa, Blanca Beatriz Espín Chico
No abstract text is available yet for this article.
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527844/altered-thoracic-cage-dimensions-in-patients-with-chronic-obstructive-pulmonary-disease
#11
Su Jin Lim, Ju Young Kim, Seung Jun Lee, Gi Dong Lee, Yu Ji Cho, Yi Yeong Jeong, Kyung Nyeo Jeon, Jong Deog Lee, Jang Rak Kim, Ho Cheol Kim
BACKGROUND: Chronic obstructive pulmonary disease (COPD) may cause changes in the shape of the thoracic cage by increasing lung volume and hyperinflation. This study investigated changes in thoracic cage dimensions and related factors in patients with COPD. METHODS: We enrolled 85 patients with COPD (76 males, 9 females; mean age, 70.6±7.1 years) and 30 normal controls. Thoracic cage dimensions were measured using chest computed tomography at levels 3, 6, and 9 of the thoracic spine...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527843/pemetrexed-continuation-maintenance-versus-conventional-platinum-based-doublet-chemotherapy-in-egfr-negative-lung-adenocarcinoma-retrospective-analysis
#12
Seung Sook Paik, In Kyoung Hwang, Myung Jae Park, Seung Hyeun Lee
BACKGROUND: Although targeted therapy and immuno-oncology have shifted the treatment paradigm for lung cancer, platinum-based combination is still the standard of care for advanced non-small cell lung cancer (NSCLC). Pemetrexed continuation maintenance therapy has been approved and increasingly used for patients with nonsquamous NSCLC. However, the efficacy of this strategy has not been proven in patients without driving mutations. The objective of this study was to compare the clinical benefit of pemetrexed continuation maintenance to conventional platinum-based doublet in epidermal growth factor receptor (EGFR)-negative lung adenocarcinoma...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29527841/comparison-of-multiple-chronic-obstructive-pulmonary-disease-copd-indices-in-chinese-copd-patients
#13
Jinsong Zhang, Anastasia Miller, Yongxia Li, Qinqin Lan, Ning Zhang, Yanling Chai, Bing Hai
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a serious chronic condition with a global impact. Symptoms of COPD include progressive dyspnea, breathlessness, cough, and sputum production, which have a considerable impact on the lives of patients. In addition to the human cost of living with COPD and the resulting death, COPD entails a huge economic burden on the Chinese population, with patients spending up to one-third of the average family income on COPD management in some regions is clinically beneficial to adopt preventable measures via prudent COPD care utilization, monetary costs, and hospitalizations...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29372631/an-increased-proportion-of-apoptosis-in-cd4%C3%A2-%C2%BA-t-lymphocytes-isolated-from-the-peripheral-blood-in-patients-with-stable-chronic-obstructive-pulmonary-disease
#14
Jinyung Ju
BACKGROUND: The pathophysiology of chronic obstructive pulmonary disease (COPD) includes inflammation, oxidative stress, an imbalance of proteases and antiproteases and apoptosis which has been focused on lately. Abnormal apoptotic events have been demonstrated in both epithelial and endothelial cells, as well as in inflammatory cells including neutrophils and lymphocytes in the lungs of COPD patients. An increased propensity of activated T lymphocytes to undergo apoptosis has been observed in the peripheral blood of COPD patients...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29372630/what-can-we-apply-to-manage-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-with-acute-respiratory-failure
#15
REVIEW
Deog Kyeom Kim, Jungsil Lee, Ju Hee Park, Kwang Ha Yoo
Acute exacerbation(s) of chronic obstructive pulmonary disease (AECOPD) tend to be critical and debilitating events leading to poorer outcomes in relation to chronic obstructive pulmonary disease (COPD) treatment modalities, and contribute to a higher and earlier mortality rate in COPD patients. Besides pro-active preventative measures intended to obviate acquisition of AECOPD, early recovery from severe AECOPD is an important issue in determining the long-term prognosis of patients diagnosed with COPD. Updated GOLD guidelines and recently published American Thoracic Society/European Respiratory Society clinical recommendations emphasize the importance of use of pharmacologic treatment including bronchodilators, systemic steroids and/or antibiotics...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29372629/chest-tube-drainage-of-the-pleural-space-a-concise-review-for-pulmonologists
#16
REVIEW
José M Porcel
Chest tube insertion is a common procedure usually done for the purpose of draining accumulated air or fluid in the pleural cavity. Small-bore chest tubes (≤14F) are generally recommended as the first-line therapy for spontaneous pneumothorax in non-ventilated patients and pleural effusions in general, with the possible exception of hemothoraces and malignant effusions (for which an immediate pleurodesis is planned). Large-bore chest drains may be useful for very large air leaks, as well as post-ineffective trial with small-bore drains...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29256215/peripheral-eosinophilia-and-clinico-radiological-characteristics-among-health-screening-program-recipients
#17
Tae Yun Park, Jae Woo Jung, Ju Young Jang, Jae Chol Choi, Jong Wook Shin, In Won Park, Byoung Whui Choi, Jae Yeol Kim
BACKGROUND: Eosinophilia is well recognized in specific conditions. The objective of the present study was to determine clinico-radiologic characteristics of eosinophilia and changes in prevalence over 10 years in recipients of private health screening program at a tertiary hospital in Korea. METHODS: Data of private health screening program recipients at the health promotion center of Chung-Ang University Hospital from 2004 to 2013 were collected. Health-related questionnaires and laboratory findings of private health screening program with possible relation with eosinophilia were reviewed...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29332324/effects-of-macrolide-and-corticosteroid-in-neutrophilic-asthma-mouse-model
#18
Tai Joon An, Chin Kook Rhee, Ji Hye Kim, Young Rong Lee, Jin Young Chon, Chan Kwon Park, Hyoung Kyu Yoon
BACKGROUND: Asthma is a disease of chronic airway inflammation with heterogeneous features. Neutrophilic asthma is corticosteroid-insensitive asthma related to absence or suppression of TH2 process and increased TH1 and/or TH17 process. Macrolides are immunomodulatory drug that reduce airway inflammation, but their role in asthma is not fully known. The purpose of this study was to evaluate the role of macrolides in neutrophilic asthma and compare their effects with those of corticosteroids...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29332323/development-of-prediction-equation-of-diffusing-capacity-of-lung-for-koreans
#19
Yong Il Hwang, Yong Bum Park, Hyoung Kyu Yoon, Seong Yong Lim, Tae Hyung Kim, Joo Hun Park, Won Yeon Lee, Seong Ju Park, Sei Won Lee, Woo Jin Kim, Ki Uk Kim, Kyeong Cheol Shin, Do Jin Kim, Hui Jung Kim, Tae Eun Kim, Kwang Ha Yoo, Jae Jeong Shim
BACKGROUND: The diffusing capacity of the lung is influenced by multiple factors such as age, sex, height, weight, ethnicity and smoking status. Although a prediction equation for the diffusing capacity of Korea was proposed in the mid-1980s, this equation is not used currently. The aim of this study was to develop a new prediction equation for the diffusing capacity for Koreans. METHODS: Using the data of the Korean National Health and Nutrition Examination Survey, a total of 140 nonsmokers with normal chest X-rays were enrolled in this study...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29332322/tumor-immunology-and-immune-checkpoint-inhibitors-in-non-small-cell-lung-cancer
#20
REVIEW
Chi Young Jung, Scott J Antonia
Lung cancer is one of the most commonly diagnosed cancers and the leading cause of cancer-related deaths worldwide. Although progress in the treatment of advanced non-small cell lung cancer (NSCLC) has been made over the past decade, the 5-year survival rate in patients with lung cancer remains only 10%-20%. Obviously, new therapeutic options are required for patients with advanced NSCLC and unmet medical needs. Cancer immunotherapy is an evolving treatment modality that uses a patient's own immune systems to fight cancer...
January 2018: Tuberculosis and Respiratory Diseases
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