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Cancer Prevention Research

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https://www.readbyqxmd.com/read/28642227/correction-whole-genome-sequencing-of-salivary-gland-adenoid-cystic-carcinoma
#1
(no author information available yet)
No abstract text is available yet for this article.
June 22, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28611039/chemoprevention-uptake-among-women-with-atypical-hyperplasia-and-lobular-and-ductal-carcinoma-in-situ
#2
Meghna S Trivedi, Austin M Coe, Alejandro Vanegas, Rita Kukafka, Katherine Crew
Women with atypical hyperplasia (AH) and lobular or ductal carcinoma in situ (LCIS/DCIS) are at increased risk of developing invasive breast cancer. Chemoprevention with selective estrogen receptor modulators or aromatase inhibitors can reduce breast cancer risk; however, uptake is estimated to be less than 15% in these populations. We sought to determine which factors are associated with chemoprevention uptake in a population of women with AH, LCIS, and DCIS. Women diagnosed with AH/LCIS/DCIS between 2007 and 2015 without a history of invasive breast cancer were identified (n=1719)...
June 13, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28611038/intermittent-dosing-with-sulindac-provides-effective-colorectal-cancer-chemoprevention-in-the-azoxymethane-treated-mouse-model
#3
Swati Chandra, Ariel C Nymeyer, Photini Faith Rice, Eugene W Gerner, Jennifer K Barton
Sulindac is a nonsteroidal anti-inflammatory drug that can provide effective chemoprevention for colorectal cancer. In this study, alternative dosing regimens of sulindac were evaluated for their chemoprevention effectiveness in the azoxymethane-treated A/J mouse model of colorectal cancer. High resolution endoscopic optical coherence tomography was utilized to time-serially measure tumor number and tumor burden in the distal colon as the biological endpoints. Four treatment groups were studied: 1) daily for 20 weeks (Sulindac-Daily), 2) for two weeks, then no sulindac for two weeks, cycle repeated 5 times (Sulindac-2), 3) for ten weeks ("on"), then no sulindac for 10 weeks ("off") (Sulindac-10), 4) no sulindac (Sulindac-None)...
June 13, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28600399/validation-of-pde5-as-a-chemoprevention-target
#4
EDITORIAL
Gary A Piazza
No abstract text is available yet for this article.
June 9, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28600398/unmetabolized-folic-acid-tetrahydrofolate-and-colorectal-adenoma-risk
#5
Judy R Rees, Carolyn B Morris, Janet L Peacock, Per Magne Ueland, Elizabeth L Barry, Gail McKeown-Eyssen, Jane C Figueiredo, Dale C Snover, Baron A John
In a randomized trial of folic acid supplementation for the prevention of colorectal adenomas, we previously found indications of increased risk during later treatment and follow-up. This could have been due to the unmetabolized folic acid or natural reduced and methylated folates to which it is metabolized. In post hoc analyses, we measured methylated folates (mF, the sum of 5-methyl-tetrahydrofolate and 4-alfa-hydroxy-5-methyl-THF) and unmetabolized folic acid (UFA) concentrations in the serum of 924 participants...
June 9, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28584169/the-effects-of-physical-activity-and-body-fat-mass-on-colorectal-polyp-recurrence-in-patients-with-previous-colorectal-cancer
#6
Jihye Park, Jae Hyun Kim, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Ji Soo Park, Justin Y Jeon, Tae Il Kim
We aimed to identify the effects of physical activity and body composition on colorectal polyp recurrence in patients with previous colorectal cancer. Three hundred patients were selected randomly from the colorectal cancer survivor cohort of Severance Hospital, Seoul, Korea. Patients reported various recreational physical activities, and received surveillance colonoscopy. Body composition was measured with a body composition analyzer. We compared patients who exercised for at least 1 h/week (active) with those who exercised less frequently or not at all (sedentary)...
June 5, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28576788/pigs-%C3%A2-unlike-mice-have-two-distinct-colonic-stem-cell-populations-similar-to-humans-that-respond-to-high-calorie-diet-prior-to-insulin-resistance
#7
Venkata Charepalli, Lavanya Reddivari, Sridhar Radhakrishnan, Elisabeth Eriksson, Xia Xiao, Sung Woo Kim, Frank Shen, Vijay Kumar Matam, Qunhua Li, Vadiraja B Bhat, Rob Knight, Jairam K P Vanamala
Basal colonic crypt stem cells are long lived and play a role in colon homeostasis. Previous evidence has shown that high-calorie diet (HCD) enhances colonic stem cell numbers and expansion of the proliferative zone, an important biomarker for colon cancer. However, it is not clear how HCD drives dysregulation of colon stem cell/colonocyte proliferative kinetics. We used a human-relevant pig model and developed an immunofluorescence technique to detect and quantify colonic stem cells. Pigs (n = 8/group) were provided either standard diet (SD; 5 % fat) or HCD (25 % fat) for 13 weeks...
June 2, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28559460/development-of-a-cancer-risk-prediction-tool-for-use-in-the-uk-primary-care-and-community-settings
#8
Artitaya Lophatananon, Juliet A Usher-Smith, Jackie Campbell, Joanne Warcaba, Barbora Silarova, Erika A Waters, Graham A Colditz, Kenneth Muir
Several multivariable risk prediction models have been developed to asses an individual's risk of developing specific cancers. Such models can be used in a variety of settings for prevention, screening and guiding investigations and treatments. Models aimed at predicting future disease risk that contains lifestyle factors may be of particular use for targeting health promotion activities at an individual level. This type of cancer risk prediction is not yet available in the UK. We have adopted the approach used by the well-established U...
May 30, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28559459/tamoxifen-acceptance-and-adherence-among-patients-with-ductal-carcinoma-in-situ-dcis-treated-in-a-multidisciplinary-setting
#9
Lindsey C Karavites, Anna K Kane, Shruti Zaveri, Yanfei Xu, Irene Helenowski, Nora Hansen, Kevin P Bethke, Laura J Rasmussen-Torvik, Seema A Khan
Tamoxifen and other endocrine agents have proven benefits for women with ductal carcinoma in situ (DCIS) but low patient acceptance is widely reported. We examined factors associated with tamoxifen acceptance and adherence among DCIS patients who received a recommendation for therapy in a multidisciplinary setting. <p>Using our institutional database, we identified women diagnosed with DCIS, 1998-2009 who were offered tamoxifen. We recorded data on demographics, tumor and therapy variables, tamoxifen acceptance, and adherence to therapy for > 4 years...
May 30, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28507039/do-aspirin-and-other-nsaids-confer-a-survival-benefit-in-men-diagnosed-with-prostate-cancer-a-pooled-analysis-of-nih-aarp-and-plco-cohorts
#10
Cindy Ke Zhou, Sarah E Daugherty, Linda M Liao, Neal D Freedman, Christian C Abnet, Ruth Pfeiffer, Michael B Cook
Prostate cancer is one of the leading causes of cancer-related death in U.S. men. There is an unmet need to identify modifiable risk factors for prostate cancer survival. Experimental studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may improve prostate cancer survival through antithrombotic and anti-inflammation mechanisms. Results from previous observational studies have been equivocal, and few have assessed whether an etiologically relevant time window of exposure exists. We sampled incident prostate cancer cases from two large U...
May 15, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28483840/fusobacterium-nucleatum-subspecies-animalis-influences-pro-inflammatory-cytokine-expression-and-monocyte-activation-in-human-colorectal-tumors
#11
Xiangcang Ye, Rui Wang, Rajat Bhattacharya, Delphine Boulbes, Fan Fan, Ling Xia, Harish Adoni, Nadim J Ajami, Matthew C Wong, Daniel P Smith, Joseph F Petrosino, Susan Venable, Wei Qiao, Veerabhadran Baladandayuthapani, Dipen M Maru, Lee M Ellis
Chronic infection and associated inflammation have long been suspected to promote human<br />carcinogenesis. Recently, certain gut bacteria, including some in the Fusobacterium genus, have been implicated in playing a role in human colorectal cancer (CRC) development. However, the Fusobacterium species and subspecies involved and their oncogenic mechanisms remain to be determined. We sought to identify the specific Fusobacterium spp. and ssp. in clinical CRC specimens by targeted sequencing of Fusobacterium 16S ribosomal RNA gene...
May 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28468928/sildenafil-suppresses-inflammation-driven-colorectal-cancer-in-mice
#12
Bianca N Islam, Sarah K Sharman, Yali Hou, Allison E Bridges, Nagendra Singh, Sangmi Kim, Ravindra Kolhe, Jimena Trillo-Tinoco, Paulo C Rodriguez, Franklin G Berger, Subbaramiah Sridhar, Darren D Browning
Intestinal cyclic guanosine monophosphate (cGMP) signaling regulates epithelial homeostasis and has been implicated in the suppression of colitis and colon cancer. In this study, we investigated the cGMP-elevating ability of the phosphodiesterase-5 (PDE5) inhibitor sildenafil to prevent disease in the azoxymethane/dextran sulfate sodium (AOM/DSS) inflammation-driven colorectal cancer model. Treatment of mice with sildenafil activated cGMP signaling in the colon mucosa and protected against DSS-induced barrier dysfunction...
May 3, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28576888/correction-new-perspectives-of-curcumin-in-cancer-prevention
#13
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28487295/statin-use-serum-lipids-and-prostate-inflammation-in-men-with-a-negative-prostate-biopsy-results-from-the-reduce-trial
#14
Emma H Allott, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Stephen J Freedland
Statin use is associated with lower advanced prostate cancer risk. In addition to cholesterol lowering, statins have systemic anti-inflammatory properties. However, their effect on histologic prostate inflammation is not well understood, particularly among men at increased prostate cancer risk but with a negative prostate biopsy. We examined associations between serum lipid levels, statin use, and histologic prostate inflammation using data from 6,655 men with a negative baseline prostate biopsy in the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial...
June 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28465362/bitter-melon-enhances-natural-killer-mediated-toxicity-against-head-and-neck-cancer-cells
#15
Sourav Bhattacharya, Naoshad Muhammad, Robert Steele, Jacki Kornbluth, Ratna B Ray
Natural killer (NK) cells are one of the major components of innate immunity, with the ability to mediate antitumor activity. Understanding the role of NK-cell-mediated tumor killing in controlling of solid tumor growth is still in the developmental stage. We have shown recently that bitter melon extract (BME) modulates the regulatory T cell (Treg) population in head and neck squamous cell carcinoma (HNSCC). However, the role of BME in NK-cell modulation against HNSCC remains unknown. In this study, we investigated whether BME can enhance the NK-cell killing activity against HNSCC cells...
June 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28400480/combined-genetic-biomarkers-and-betel-quid-chewing-for-identifying-high-risk-group-for-oral-cancer-occurrence
#16
Chia-Min Chung, Chien-Hung Lee, Mu-Kuan Chen, Ka-Wo Lee, Cheng-Che E Lan, Aij-Lie Kwan, Ming-Hsui Tsai, Ying-Chin Ko
We integrated genetic risk scores (GRS) and environmental factors for identifying high-risk subjects for oral squamous cell carcinoma (OSCC) occurrence by using case-control study. A total of 447 patients diagnosed with OSCC and 580 unrelated subjects were recruited from two medical centers in Taiwan. A multinomial logistic regression model was conducted to access interaction between GRS and betel quid (BQ) chewing. We employed ROC curve to compare the accuracy of OSCC occurrence. Four tag SNPs were found in NOTCH1, BRCA1, COL9A1, and HSPA13 genes that were significantly associated with OSCC occurrence...
June 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28400479/a-presurgical-study-of-lecithin-formulation-of-green-tea-extract-in-women-with-early-breast-cancer
#17
Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Sara Gandini, Harriet Johansson, Davide Serrano, Massimiliano Cazzaniga, Valentina Aristarco, Debora Macis, Serena Mora, Pietro Caldarella, Gianmatteo Pagani, Giancarlo Pruneri, Antonella Riva, Giovanna Petrangolini, Paolo Morazzoni, Andrea DeCensi, Bernardo Bonanni
Epidemiologic data support an inverse association between green tea intake and breast cancer risk. Greenselect Phytosome (GSP) is a lecithin formulation of a caffeine-free green tea catechin extract. The purpose of the study was to determine the tissue distribution of epigallocatechin-3-O-gallate (EGCG) and its effect on cell proliferation and circulating biomarkers in breast cancer patients. Twelve early breast cancer patients received GSP 300 mg, equivalent to 44.9 mg of EGCG, daily for 4 weeks prior to surgery...
June 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28396341/bioactivity-of-oral-linaclotide-in-human-colorectum-for-cancer-chemoprevention
#18
David S Weinberg, Jieru E Lin, Nathan R Foster, Gary Della'Zanna, Asad Umar, Drew Seisler, Walter K Kraft, David M Kastenberg, Leo C Katz, Paul J Limburg, Scott A Waldman
Guanylate cyclase C (GUCY2C) is a tumor-suppressing receptor silenced by loss of expression of its luminocrine hormones guanylin and uroguanylin early in colorectal carcinogenesis. This observation suggests oral replacement with a GUCY2C agonist may be an effective targeted chemoprevention agent. Linaclotide is an FDA-approved oral GUCY2C agonist formulated for gastric release, inducing fluid secretion into the small bowel to treat chronic idiopathic constipation. The ability of oral linaclotide to induce a pharmacodynamic response in epithelial cells of the colorectum in humans remains undefined...
June 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28377487/sleep-duration-across-the-adult-lifecourse-and-risk-of-lung-cancer-mortality-a-cohort-study-in-xuanwei-china
#19
Jason Y Wong, Bryan A Bassig, Roel Vermeulen, Wei Hu, Bofu Ning, Wei Jie Seow, Bu-Tian Ji, George S Downward, Hormuzd A Katki, Francesco Barone-Adesi, Nathaniel Rothman, Robert S Chapman, Qing Lan
Sufficient sleep duration is crucial for maintaining normal physiological function and has been linked to cancer risk; however, its contribution to lung cancer mortality is unclear. Therefore, we evaluated the relationship between average sleep duration in various age-periods across the adult lifecourse, and risk of lung cancer mortality in Xuanwei, China. An ambidirectional cohort study was conducted in 42,422 farmers from Xuanwei, China. Participants or their surrogates were interviewed in 1992 to assess average sleep hours in the age periods of 21-30, 31-40, 41-50, 51-60, 61-70, and ≥71 years, which were categorized as ≤7, 8 (reference), 9, and ≥10 hours/day...
June 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28408379/-obesity-associated-breast-cancer-in-lean-women-metabolism-and-inflammation-as-critical-modifiers-of-risk
#20
EDITORIAL
Gerald V Denis, Julie R Palmer
Why is obesity only weakly associated with certain "obesity-driven" cancers? Recent population studies identify cohorts of high body mass index (BMI) subjects with unexpectedly reduced risk for breast and colon cancer, and normal BMI subjects with unexpectedly elevated risk for breast cancer, provoking hard thinking about cellular and molecular mechanisms that most strongly couple obesity to cancer occurrence or progression. Emerging work suggests that abnormal metabolism and its associated chronic inflammation make the difference...
May 2017: Cancer Prevention Research
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