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Cancer Prevention Research

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https://www.readbyqxmd.com/read/30232083/fallopian-tube-lesions-in-women-at-high-risk-for-ovarian-cancer-a-multicenter-study
#1
Kala Visvanathan, Patricia Shaw, Betty J May, Asli Bahadirli-Talbot, Alpana Kaushiva, Harvey Risch, Steven Narod, Tian-Li Wang, Vinita Parkash, Russell Vang, Douglas A Levine, Robert Soslow, Robert Kurman, Ie-Ming Shih
The prognosis of women diagnosed with invasive high-grade serous ovarian carcinoma (HGSC) is poor. More information about Serous tubal intraepithelial carcinoma (STIC) and Serous tubal intraepithelial lesions (STILs), putative precursor lesions of HGSC could inform prevention efforts. We conducted a multicenter study to identify risk/protective factors associated with STIC/STILs and characterize p53 signatures in the fallopian tube. The fallopian tubes and ovaries of 479 high-risk women > 30 years of age who underwent bilateral risk-reducing salpingo-oophorectomy were reviewed for invasive cancer/STICs/STILs...
September 19, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30213786/methylation-and-expression-of-non-clustered-protocadherins-encoding-genes-and-risk-of-precancerous-gastric-lesions-in-a-high-risk-population
#2
Si Wu, Yang Zhang, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wen-Qing Li, Wei-Cheng You, Kai-Feng Pan
Non-clustered protocadherins (PCDHs) family is a group of cell-cell adhesion molecules. We have found differentially methylated genes in the non-clustered PCDHs family associated with Helicobacter pylori (H. pylori) infection in prior genome-wide methylation analysis. To further investigate the methylation and expression of non-clustered PCDHs encoding genes in H. pylori-related gastric carcinogenesis process, four candidate genes including PCDH7, PCDH10, PCDH17 and PCDH20 were selected, which were reported to be tumor suppressors for digestive cancers...
September 13, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30209117/effects-of-supplemental-calcium-and-vitamin-d-on-expression-of-toll-like-receptors-and-phospho-ikk%C3%AE-%C3%AE-in-the-normal-rectal-mucosa-of-colorectal-adenoma-patients
#3
Rebecca A Hodge, Hannah B Mandle, Stephen Ray, Sonia Tandon, Meaghan Peterson, Abigail Henry, Ferdous Akter Jahan, Roberd M Bostick, John A Baron, Elizabeth L Barry, Rami Yacoub, Robin E Rutherford, March E Seabrook, Veronika Fedirko
Chronic inflammation in the colorectum, a significant contributor to colorectal carcinogenesis, can be triggered by the activation of pro-inflammatory signaling pathways such as those initiated by Toll-like receptors (TLRs) and nuclear factor κB (NF-κB). Although experimental evidence supports calcium and vitamin D potentially modifying these pro-inflammatory pathways in the colorectum, human data in these regards are scarce. We investigated supplemental calcium (1,200 mg daily) and/or vitamin D3 (1,000 IU daily) effects on inflammatory signaling pathway-related biomarkers in a subset of 105 participants from a colorectal adenoma recurrence chemoprevention clinical trial...
September 12, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30139875/early-life-alcohol-intake-and-high-grade-prostate-cancer-results-from-an-equal-access-racially-diverse-biopsy-cohort
#4
Jamie Michael, Lauren E Howard, Sarah C Markt, Amanda De Hoedt, Charlotte Bailey, Lorelei A Mucci, Stephen J Freedland, Emma H Allott
Epidemiologic evidence for an association between alcohol and prostate cancer is mixed. Moreover, there is a lack of research investigating early-life alcohol intake as a risk factor for either overall or high-grade prostate cancer. We examined lifetime alcohol intake in association with prostate cancer diagnosis in an equal-access, racially diverse prostate biopsy cohort. Men undergoing prostate biopsy at the Durham Veterans Affairs Medical Center from 2007 to 2018 completed a survey indicating average number of alcoholic beverages consumed per week [categorized as none (ref), 1-6, ≥7] during each decade of life...
August 23, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30131435/prevention-of-lipid-peroxidation-derived-cyclic-dna-adduct-and-mutation-in-high-fat-diet-induced-hepatocarcinogenesis-by-theaphenon-e
#5
Heidi Coia, Ning Ma, Yanqi Hou, Marcin D Dyba, Ying Fu, M Idalia Cruz, Carlos Benitez, Garrett T Graham, Justine N McCutcheon, Yun-Ling Zheng, Bing Sun, Bhaskar V S Kallakury, Junfeng Ma, Hong-Bin Fang, Deborah L Berry, Vinona Muralidaran, Fung-Lung Chung
Obesity is associated with cancer risk and its link with liver cancer is particularly strong. Obesity causes non-alcoholic fatty liver disease (NAFLD) that could progress to hepatocellular carcinoma (HCC). Chronic inflammation likely plays a key role. We carried out a bioassay in the high fat diet (HFD) fed C57BL/6J mice to provide insight into the mechanisms of obesity-related HCC by studying γ-OHPdG, a mutagenic DNA adduct derived from lipid peroxidation. In an 80-week bioassay, mice received a low fat diet (LFD), high fat diet (HFD) or HFD with 2% Theaphenon E (HFD+TE)...
August 21, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30104415/germline-and-somatic-nf1-alterations-are-linked-to-increased-her2-expression-in-breast-cancer
#6
Xia Wang, Roope A Kallionpää, Patrick R Gonzales, Dhananjay A Chitale, Renee N Tousignant, Jacob P Crowley, Zhihua Chen, Sean J Yoder, Jaishri O Blakeley, Maria T Acosta, Bruce R Korf, Ludwine M Messiaen, Michael A Tainsky
NF1 germline mutation predisposes to breast cancer. NF1 mutations have also been proposed as oncogenic drivers in sporadic breast cancers. To understand the genomic and histological characteristics of these breast cancers, we analyzed the tumors with NF1 germline mutations and also examined the genomic and proteomic profiles of unselected tumors. Among 14 breast cancer specimens from 13 women affected with neurofibromatosis type 1 (NF1), 9 samples (NF+BrCa) underwent genomic copy number (CN) and targeted sequencing analysis...
August 13, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30045935/prostacyclin-and-emt-pathway-markers-for-monitoring-response-to-lung-cancer-chemoprevention
#7
Melissa L New, Collin M White, Polly McGonigle, Debbie G McArthur, Lori D Dwyer-Nield, Daniel T Merrick, Robert L Keith, Meredith A Tennis
Lung cancer is the leading cause of cancer death worldwide and global burden could be reduced through targeted application of chemoprevention. The development of squamous lung carcinoma has been linked with persistent, high grade bronchial dysplasia. Bronchial histology improved in former smokers in a chemoprevention trial with the prostacyclin analogue iloprost. ]=Prostacyclin acts through peroxisome proliferator-activated receptor gamma (PPARg) to reverse epithelial to mesenchymal transition and promote anti-cancer signaling...
July 25, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30045934/screening-of-chemopreventive-agents-in-animal-models-results-on-reproducibility-agents-of-a-given-class-and-agents-tested-during-tumor-progression
#8
REVIEW
Ronald A Lubet, Vernon E Steele, Robert H Shoemaker, Clinton J Grubbs
Because of the importance of testing reproducibility of results, we present our findings regarding screening agents in preclinical chemoprevention studies in rodent models performed by the Chemopreventive Agent Development Research Group (CADRG) of the Division of Cancer Prevention of the NCI. These studies were performed via contracts to various commercial and academic laboratories. Primarily, results with positive agents are reported because positive agents may progress to the clinics. In testing reproducibility, a limited number of direct repeats of our standard screening assays were performed; which entailed initiating treatment shortly after carcinogen administration or in young transgenic mice and continuing treatment until the end of the study...
July 25, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30021726/aspirin-suppresses-pge-2-and-activates-amp-kinase-to-inhibit-melanoma-cell-motility-pigmentation-and-selective-tumor-growth-in-vivo
#9
Dileep Kumar, Hafeez Rahman, Ethika Tyagi, Tong Liu, Chelsea Li, Ran Lu, David Lum, Sheri L Holmen, John A Maschek, James E Cox, Matthew W VanBrocklin, Douglas Grossman
There are conflicting epidemiologic data on whether chronic aspirin (ASA) use may reduce melanoma risk in humans. Potential anti-cancer effects of ASA may be mediated by its ability to suppress prostaglandin E2 (PGE2) production and activate 5'-adenosine monophosphate-activated protein kinase (AMPK). We investigated the inhibitory effects of ASA in a panel of melanoma and transformed melanocyte cell lines, and on tumor growth in a preclinical model. ASA and the COX-2 inhibitor Celecoxib did not affect melanoma cell viability, but significantly reduced colony formation, cell motility, and pigmentation (melanin production) in vitro at concentrations of 1 mM and 20 uM, respectively...
July 18, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29980517/the-ashitaba-angelica-keiskei-chalcones-4-hydroxyderricin-and-xanthoangelol-suppress-melanomagenesis-by-targeting-braf-and-pi3-k
#10
Tianshun Zhang, Qiushi Wang, Mangaladoss Fredimoses, Ge Gao, Keke Wang, Hanyong Chen, Ting Wang, Naomi Oi, Tatyana Zykova, Kanamata Reddy, Ke Yao, Weiya Ma, Xiaoyu Chang, Mee-Hyun Lee, Moeez Ghani Rathore, Ann M Bode, Hitoshi Ashida, Scott M Lippman, Zigang Dong
Malignant melanoma is an aggressive tumor of the skin and still lacks effective preventive and therapeutic treatments. In melanoma, both the BRAF/MEK/ERK and PI3-K/AKT signaling pathways are constitutively activated through multiple mechanisms, which result in cell cycle progression and prevention of apoptosis. Therefore, the development of novel strategies for targeting BRAF and PI3-K are of utmost importance. In the current study, we found that Ashitaba (Angelica keiskei) chalcones, 4-hydroxyderricin (4HD) and xanthoangelol (XAG), suppressed melanoma development by directly targeting both BRAFV600E and PI3-K, which blocked the activation of downstream signaling...
July 6, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30181122/retraction-gambogic-acid-inhibits-stat3-phosphorylation-through-activation-of-protein-tyrosine-phosphatase-shp-1-potential-role-in-proliferation-and-apoptosis
#11
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29991580/high-growth-rate-of-pancreatic-ductal-adenocarcinoma-in-cdkn2a-p16-leiden-mutation-carriers
#12
Isaura S Ibrahim, Martin N Wasser, Yinghui Wu, Akin Inderson, Wouter H de Vos Tot Nederveen Cappel, Hans Morreau, Frederik J Hes, Roeland A Veenendaal, Hein Putter, Shirin Feshtali, Anneke M van Mil, Nelleke A Gruis, Rob A Tollenaar, Wilma Bergman, Bert A Bonsing, Hans F A Vasen
CDKN2A - p16-Leiden mutation carriers have a 20% to 25% risk of developing pancreatic ductal adenocarcinoma (PDAC). Better understanding of the natural course of PDAC might allow the surveillance protocol to be improved. The aims of the study were to evaluate the role of cystic precursor lesions in the development of PDAC and to assess the growth rate. In 2000, a surveillance program was initiated, consisting of annual MRI in carriers of a CDKN2A-p16-Leiden mutation. The study cohort included 204 (42% male) patients...
September 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29991579/detection-and-genotyping-of-hpv-dna-in-a-group-of-unvaccinated-young-women-from-colombia-baseline-measures-prior-to-future-monitoring-program
#13
Devi Puerto, Viviana Reyes, Cristina Lozano, Lina Buitrago, Diego Garcia, Raúl H Murillo, Nubia Muñoz, Gustavo A Hernandez, Laura Sanchez, Carolina Wiesner, Alba L Combita
In 2012, Colombia launched human papillomavirus (HPV) vaccination program for girls ages 9 to 12, and in 2013, the target age was expanded to 9 to 17 years. Monitoring the changes of HPV infection prevalence among young women has been proposed as an endpoint for early assessment of HPV vaccination programs. However, the data on HPV prevalence in young ages are very limited. The purpose of this study was to determine the prevalence of HPV infection and the distribution of genotypes in a group of nonvaccinated women ages 18 to 25 years old in three Colombian cities as baseline for the monitoring of the HPV national vaccination program...
September 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29991578/sex-specific-association-between-family-history-of-diabetes-and-risk-of-colorectal-cancer-two-prospective-cohort-studies
#14
Wenjie Ma, Mingyang Song, Ane Sørlie Kværner, Jennifer Prescott, Andrew Chan, Edward Giovannucci, Xuehong Zhang
Type 2 diabetes (T2D) is associated with increased risk of colorectal cancer. It remains unclear whether family history of diabetes influences colorectal cancer risk and relevant biomarkers. We followed 101,323 women from the Nurses' Health Study (1982-2012) and 48,542 men from the Health Professionals Follow-up Study (1988-2012), free of cancer and inflammatory bowel disease at baseline. Participants reported whether any of their first-degree family members ever had diabetes in multiple questionnaires administered biennially...
September 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29954759/targeting-colon-luminal-lipid-peroxidation-limits-colon-carcinogenesis-associated-with-red-meat-consumption
#15
Océane C B Martin, Nathalie Naud, Sylviane Taché, Laurent Debrauwer, Sylvie Chevolleau, Jacques Dupuy, Céline Chantelauze, Denis Durand, Estelle Pujos-Guillot, Florence Blas-Y-Estrada, Christine Urbano, Gunter G C Kuhnle, Véronique Santé-Lhoutellier, Thierry Sayd, Didier Viala, Adeline Blot, Nathalie Meunier, Pascal Schlich, Didier Attaix, Françoise Guéraud, Valérie Scislowski, Denis E Corpet, Fabrice H F Pierre
Red meat is probably carcinogenic to humans (WHO/IARC class 2A), in part through heme iron-induced lipoperoxidation. Here, we investigated whether red meat promotes carcinogenesis in rodents and modulates associated biomarkers in volunteers, speculating that an antioxidant marinade could suppress these effects via limitation of the heme induced lipid peroxidation. We gave marinated or non-marinated beef with various degrees of cooking to azoxymethane-initiated rats, Min mice, and human volunteers (crossover study)...
September 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29954758/breast-hormone-concentrations-in-random-fine-needle-aspirates-of-healthy-women-associate-with-cytological-atypia-and-gene-methylation
#16
Oukseub Lee, Richard E Heinz, David Ivancic, Miguel Muzzio, Robert T Chatterton, Carola M Zalles, Kara Keeney, Belinda Phan, Dachao Liu, Denise Scholtens, Mary Jo Fackler, Vered Stearns, Saraswati Sukumar, Seema A Khan
Sex steroid hormones contribute to breast cancer development, but data on concentrations of these within breast tissue are limited. We performed simultaneous multiparameter measurement of breast sex steroids, breast epithelial cytology, and DNA methylation in 119 healthy women (54 pre- and 65 postmenopausal) without a history of breast cancer. Random fine-needle aspiration (rFNA) of the breast was performed simultaneously with blood collection. Breast samples were analyzed by LC/MS-MS for estrone, estradiol, progesterone, androstenedione, and testosterone...
September 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29925515/change-in-inflammatory-biomarkers-and-adipose-tissue-in-brca1-2-breast-cancer-survivors-following-a-yearlong-lifestyle-modification-program
#17
Kathleen M Sturgeon, Wayne Foo, Mariane Heroux, Kathryn Schmitz
Breast cancer survivors who carry a genetic mutation for one of the BRCA genes often undergo surgically induced menopause a decade or more before the usual age of natural menopause. These women are at elevated risk for multiple negative health outcomes, including metabolic diseases, heart disease, and cancer recurrence. Effects of a 12-month commercially available web-based lifestyle program (Precision Nutrition) were tested on body composition and markers of inflammation in a randomized controlled trial. Participants ( N = 35) were BRCA1/2 + , breast cancer survivors, and had completed surgically induced menopause at age <45 years...
September 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29789344/pgc-1%C3%AE-as-a-biomarker-of-physical-activity-protective-effect-on-colorectal-cancer
#18
REVIEW
Fernanda de Souza-Teixeira, Jéssica Alonso-Molero, Carlos Ayán, Laura Vilorio-Marques, Antonio Jose Molina, Carmen González-Donquiles, Veronica Dávila-Batista, Tania Fernández-Villa, Jose Antonio de Paz, Vicente Martín
Colorectal cancer is a significant public health concern. As a multistage and multifactorial disease, environmental and genetic factors interact at each stage of the process, and an individual's lifestyle also plays a relevant role. We set out to review the scientific evidence to study the need to investigate the role of the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) gene as a biomarker of the physical activity's (PA) effect on colorectal cancer. PA is a protective factor against colorectal cancer and usually increases the expression of PGC-1α This gene has pleiotropic roles and is the main regulator of mitochondrial functions...
September 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29903741/-in-vivo-multimodal-optical-imaging-improved-detection-of-oral-dysplasia-in-low-risk-oral-mucosal-lesions
#19
Eric C Yang, Richard A Schwarz, Alexander K Lang, Nancy Bass, Hawraa Badaoui, Imran S Vohra, Katelin D Cherry, Michelle D Williams, Ann M Gillenwater, Nadarajah Vigneswaran, Rebecca R Richards-Kortum
Early detection of oral cancer and oral premalignant lesions (OPL) containing dysplasia could improve oral cancer outcomes. However, general dental practitioners have difficulty distinguishing dysplastic OPLs from confounder oral mucosal lesions in low-risk populations. We evaluated the ability of two optical imaging technologies, autofluorescence imaging (AFI) and high-resolution microendoscopy (HRME), to diagnose moderate dysplasia or worse (ModDys+ ) in 56 oral mucosal lesions in a low-risk patient population, using histopathology as the gold standard, and in 46 clinically normal sites...
August 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29895583/dna-methylation-of-telomere-related-genes-and-cancer-risk
#20
Brian T Joyce, Yinan Zheng, Drew Nannini, Zhou Zhang, Lei Liu, Tao Gao, Masha Kocherginsky, Robert Murphy, Hushan Yang, Chad J Achenbach, Lewis R Roberts, Mirjam Hoxha, Jincheng Shen, Pantel Vokonas, Joel Schwartz, Andrea Baccarelli, Lifang Hou
Researchers hypothesized that telomere shortening facilitates carcinogenesis. Previous studies found inconsistent associations between blood leukocyte telomere length (LTL) and cancer. Epigenetic reprogramming of telomere maintenance mechanisms may help explain this inconsistency. We examined associations between DNA methylation in telomere-related genes (TRG) and cancer. We analyzed 475 participants providing 889 samples 1 to 3 times (median follow-up, 10.1 years) from 1999 to 2013 in the Normative Aging Study...
August 2018: Cancer Prevention Research
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