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Journal of the International AIDS Society

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https://www.readbyqxmd.com/read/30225946/retention-on-art-and-predictors-of-disengagement-from-care-in-several-alternative-community-centred-art-refill-models-in-rural-swaziland
#1
Lorraine Pasipamire, Robin C Nesbitt, Sindiso Ndlovu, Gibson Sibanda, Sipho Mamba, Nomthandazo Lukhele, Munyaradzi Pasipamire, Serge M Kabore, Barbarba Rusch, Iza Ciglenecki, Bernhard Kerschberger
INTRODUCTION: A broad range of community-centred care models for patients stable on anti-retroviral therapy (ART) have been proposed by the World Health Organization to better respond to patient needs and alleviate pressure on health systems caused by rapidly growing patient numbers. Where available, often a single alternative care model is offered in addition to routine clinical care. We operationalized several community-centred ART delivery care models in one public sector setting. Here, we compare retention in care and on ART and identify predictors of disengagement with care...
September 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30225927/sexually-transmitted-infections-and-hiv-rna-levels-in-blood-and-anogenital-compartments-among-thai-men-who-have-sex-with-men-before-and-after-antiretroviral-therapy-implication-for-treatment-as-prevention-programme
#2
Nittaya Phanuphak, Supanit Pattanachaiwit, Tippawan Pankam, Nipat Teeratakulpisarn, Parinya Chamnan, Panita Pathipvanich, Suchart Thongpaen, Siriporn Nonenoy, Jureeporn Jantarapakde, Supabhorn Pengnonyang, Deondara Trachunthong, Thanthip Sungsing, Kittiyaporn Parasate, Sriprai Seeneewong Na Ayutthaya, Ketmookda Trairat, Kanitta Pussadee, Cheewanan Lertpiriyasuwat, Praphan Phanuphak
INTRODUCTION: Sexually transmitted infections (STIs) are common among HIV-positive men who have sex with men (MSM). There have been concerns that undiagnosed and untreated STIs could undermine efforts to use antiretroviral therapy (ART) for prevention due to genital secretion infectiousness. We evaluated the correlation between STIs and HIV RNA in anogenital compartments among HIV-positive MSM before and after ART. METHODS: MSM participants newly diagnosed with HIV were offered ART regardless of CD4 count during November 2012 to November 2015...
September 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30225908/adolescent-pregnancy-at-antiretroviral-therapy-art-initiation-a-critical-barrier-to-retention-on-art
#3
Harriet Nuwagaba-Biribonwoha, Agnes N Kiragga, Constantin T Yiannoutsos, Beverly S Musick, Kara K Wools-Kaloustian, Samuel Ayaya, Hilary Wolf, Emmanuel Lugina, John Ssali, Elaine J Abrams, Batya Elul
INTRODUCTION: Adolescence and pregnancy are potential risk factors for loss to follow-up (LTFU) while on antiretroviral therapy (ART). We compared adolescent and adult LTFU after ART initiation to quantify the impact of age, pregnancy, and site-level factors on LTFU. METHODS: We used routine clinical data for patients initiating ART as young adolescents (YA; 10 to 14 years), older adolescents (OA; 15 to 19 years) and adults (≥20 years) from 2000 to 2014 at 52 health facilities affiliated with the International epidemiology Databases to Evaluate AIDS (IeDEA) East Africa collaboration...
September 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30168275/a-commitment-to-hiv-diagnostic-accuracy-a-comment-on-towards-more-accurate-hiv-testing-in-sub-saharan-africa-a-multi-site-evaluation-of-hiv-rdts-and-risk-factors-for-false-positives-and-hiv-misdiagnosis-in-sub-saharan-africa-a-performance-of-diagnostic-algorithms
#4
Amy S Kravitz Del Solar, Bharat Parekh, Meaghan O'Keefe Douglas, Dianna Edgil, Joel Kuritsky, John Nkengasong
As part of the global response to the HIV/AIDS epidemic, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) is committed to the provision of high-quality services and ensuring testing accuracy. Two recently published papers focusing on HIV testing and misdiagnosis in sub-Saharan Africa by Kosack et al. report on evaluations of HIV rapid diagnostic tests (RDTs) and found lower than expected specificity and sensitivity on some tests when used in certain geographic locations. The magnitude of PEPFAR's global HIV response has been possible due to the extensive use of RDTs, which have made HIV diagnosis accessible all over the world...
August 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30152004/perspectives-of-south-african-youth-in-the-development-of-an-implant-for-hiv-prevention
#5
Emily A Krogstad, Millicent Atujuna, Elizabeth T Montgomery, Alexandra Minnis, Sheily Ndwayana, Tsholofelo Malapane, Mary Kate Shapley-Quinn, Kgahlisho Manenzhe, Linda-Gail Bekker, Ariane van der Straten
INTRODUCTION: Implants are a new dosage form in development for HIV pre-exposure prophylaxis (PrEP) with potential for high adherence given that they are provider-administered and are intended for long-acting protection. Integrating end-user preference into early stage product development may further overcome challenges with future product uptake and adherence. Hence, we sought to optimize the design of a PrEP implant in early-stage development by gathering opinions about implant attributes from potential end-users in South Africa...
August 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30101439/fame-04-a-phase-1-trial-to-assess-the-safety-acceptability-pharmacokinetics-and-pharmacodynamics-of-film-and-gel-formulations-of-tenofovir
#6
Katherine E Bunge, Charlene S Dezzutti, Craig W Hendrix, Mark A Marzinke, Hans M L Spiegel, Bernard J Moncla, Jill L Schwartz, Leslie A Meyn, Nicola Richardson-Harman, Lisa C Rohan, Sharon L Hillier
INTRODUCTION: Fast-dissolving vaginal film formulations release antiretroviral drugs directly into vaginal fluid and may be as efficient at drug delivery yet more acceptable to women than gels. In this Phase 1 vaginal film study, the safety, acceptability, pharmacokinetics and pharmacodynamics of two doses of tenofovir (TFV) film and TFV 1% gel were compared to corresponding placebo formulations. METHODS: Seventy-eight healthy HIV negative women were randomized to self-insert daily vaginal film (10 mg TFV, 40 mg TFV or placebo) or 4 mL of vaginal gel (TFV 1% [40 mg] or placebo) for seven days...
August 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30101434/detection-of-hypermethylated-genes-as-markers-for-cervical-screening-in-women-living-with-hiv
#7
Wieke W Kremer, Marjolein Van Zummeren, Putri W Novianti, Karin L Richter, Wina Verlaat, Peter Jf Snijders, Daniëlle Am Heideman, Renske Dm Steenbergen, Greta Dreyer, Chris Jlm Meijer
INTRODUCTION: To evaluate the performance of hypermethylation analysis of ASCL1, LHX8 and ST6GALNAC5 in physician-taken cervical scrapes for detection of cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 in women living with HIV (WLHIV) in South Africa. METHODS: Samples from a prospective observational cohort study were used for these analyses. Two cohorts were included: a cohort of WLHIV who were invited for cervical screening (n = 321) and a gynaecologic outpatient cohort of women referred for evaluation of abnormal cytology or biopsy proven cervical cancer (n = 108, 60% HIV seropositive)...
August 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30094952/hiv-viral-suppression-and-longevity-among-a-cohort-of-children-initiating-antiretroviral-therapy-in-eastern-cape-south-africa
#8
Chloe A Teasdale, Nonzwakazi Sogaula, Katharine A Yuengling, Chunhui Wang, Anthony Mutiti, Stephen Arpadi, Mahlubandile Nxele, Lungile Pepeta, Mary Mogashoa, Emilia D Rivadeneira, Elaine J Abrams
INTRODUCTION: There are limited data on viral suppression (VS) in children with HIV receiving antiretroviral therapy (ART) in routine care in low-resource settings. We examined VS in a cohort of children initiating ART in routine HIV care in Eastern Cape Province, South Africa. METHODS: The Pediatric Enhanced Surveillance Study enrolled HIV-infected ART eligibility children zero to twelve years at five health facilities from 2012 to 2014. All children received routine HIV care and treatment services and attended quarterly study visits for up to 24 months...
August 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30063290/hiv-knowledge-trends-during-an-era-of-rapid-antiretroviral-therapy-scale-up-an-analysis-of-33-sub-saharan-african-countries
#9
Brian T Chan, Alexander C Tsai
INTRODUCTION: Population-level improvements in knowledge about HIV may reduce the stigma attached to HIV and ensure maximal uptake of HIV prevention initiatives. The extent to which levels of HIV knowledge in the general population of sub-Saharan Africa have changed in the current era of antiretroviral therapy (ART) scale-up remains unknown. METHODS: Data on HIV knowledge in the general population were drawn from the 2003 to 2015 Demographic and Health Surveys (DHS) and AIDS Indicator Surveys (AIS) of 33 countries in sub-Saharan Africa...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30063287/high-hiv-and-active-tuberculosis-prevalence-and-increased-mortality-risk-in-adults-with-symptoms-of-tb-a-systematic-review-and-meta-analyses
#10
REVIEW
Marriott Nliwasa, Peter MacPherson, Ankur Gupta-Wright, Mphatso Mwapasa, Katherine Horton, Jon Ø Odland, Clare Flach, Elizabeth L Corbett
INTRODUCTION: HIV and tuberculosis (TB) remain leading causes of preventable death in low- and middle-income countries (LMICs). The World Health Organization (WHO) recommends HIV testing for all individuals with TB symptoms, but implementation has been suboptimal. We conducted a systematic literature review and meta-analyses to estimate HIV and TB prevalence, and short-term (two to six months) mortality, among adults with TB symptoms at community- and facility level. METHODS: We searched Embase, Global Health and MEDLINE databases, and reviewed conference abstracts for studies reporting simultaneous HIV and TB screening of adults in LMICs published between January 2003 and December 2017...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30051631/oral-abstracts-of-the-22nd-international-aids-conference-23-27-july-2018-amsterdam-the-netherlands
#11
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30047573/using-safe-affordable-and-accessible-non-steroidal-anti-inflammatory-drugs-to-reduce-the-number-of-hiv-target-cells-in-the-blood-and-at-the-female-genital-tract
#12
Julie Lajoie, Kenzie Birse, Lucy Mwangi, Yufei Chen, Juliana Cheruiyot, Maureen Akolo, John Mungai, Genevieve Boily-Larouche, Laura Romas, Sarah Mutch, Makobu Kimani, Julius Oyugi, Emmanuel A Ho, Adam Burgener, Joshua Kimani, Keith R Fowke
INTRODUCTION: At its basic level, HIV infection requires a replication-competent virus and a susceptible target cell. Elevated levels of vaginal inflammation has been associated with the increased risk of HIV infection as it brings highly activated HIV target cells (CCR5+CD4+ T cells; CCR5+CD4+CD161+ Th17 T cells) to the female genital tract (FGT) where they interact with HIV. Decreased HIV risk has been associated with a phenotype of decreased immune activation, called immune quiescence, described among Kenyan female sex workers who were intensely exposed to HIV yet remain uninfected...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30044059/expert-consensus-statement-on-the-science-of-hiv-in-the-context-of-criminal-law
#13
Françoise Barré-Sinoussi, Salim S Abdool Karim, Jan Albert, Linda-Gail Bekker, Chris Beyrer, Pedro Cahn, Alexandra Calmy, Beatriz Grinsztejn, Andrew Grulich, Adeeba Kamarulzaman, Nagalingeswaran Kumarasamy, Mona R Loutfy, Kamal M El Filali, Souleymane Mboup, Julio Sg Montaner, Paula Munderi, Vadim Pokrovsky, Anne-Mieke Vandamme, Benjamin Young, Peter Godfrey-Faussett
INTRODUCTION: Globally, prosecutions for non-disclosure, exposure or transmission of HIV frequently relate to sexual activity, biting, or spitting. This includes instances in which no harm was intended, HIV transmission did not occur, and HIV transmission was extremely unlikely or not possible. This suggests prosecutions are not always guided by the best available scientific and medical evidence. DISCUSSION: Twenty scientists from regions across the world developed this Expert Consensus Statement to address the use of HIV science by the criminal justice system...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30044056/addressing-hiv-criminalization-science-confronts-ignorance-and-bias
#14
EDITORIAL
Kenneth H Mayer, Annette Sohn, Susan Kippax, Marlène Bras
No abstract text is available yet for this article.
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30033684/social-network-methods-for-hiv-case-finding-among-people-who-inject-drugs-in-tajikistan
#15
Maxim Kan, Danielle B Garfinkel, Olga Samoylova, Robert P Gray, Kristen M Little
INTRODUCTION: HIV testing programmes have struggled to reach the most marginalized populations at risk for HIV. Social network methods such as respondent-driven sampling (RDS) and peer-based active case-finding (ACF) may be effective in overcoming barriers to reaching these populations. We compared the client characteristics, proportion testing HIV positive (yield), and number of new cases found through two RDS strategies and an ACF approach to HIV case-finding among people who inject drugs (PWID) in Tajikistan...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30033680/uptake-of-hiv-self-testing-and-linkage-to-treatment-among-men-who-have-sex-with-men-msm-in-nigeria-a-pilot-programme-using-key-opinion-leaders-to-reach-msm
#16
Waimar Tun, Lung Vu, Osasuyi Dirisu, Adekemi Sekoni, Elizabeth Shoyemi, Jean Njab, Sade Ogunsola, Sylvia Adebajo
INTRODUCTION: HIV self-testing (HIVST) offers an alternative to facility-based HIV testing services, particularly for populations such as men who have sex with men (MSM) who may fear accessing testing due to stigma, discrimination and criminalization. Innovative HIV testing approaches are needed to meet the goal of 90% of people living with HIV being diagnosed. This study piloted an intervention to distribute oral HIVST kits to MSM through key opinion leaders (KOLs) in Lagos, Nigeria and assessed the feasibility, acceptability, uptake of HIVST and linkage to HIV treatment...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30033673/building-the-evidence-base-to-optimize-the-impact-of-key-population-programming-across-the-hiv-cascade
#17
EDITORIAL
R Cameron Wolf, Trista Bingham, Greg Millett, Rose Wilcher
No abstract text is available yet for this article.
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30033654/gaps-and-opportunities-measuring-the-key-population-cascade-through-surveys-and-services-to-guide-the-hiv-response
#18
Avi Joseph Hakim, Virginia MacDonald, Wolfgang Hladik, Jinkou Zhao, Janet Burnett, Keith Sabin, Dimitri Prybylski, Jesus Maria Garcia Calleja
INTRODUCTION: The UNAIDS 90-90-90 targets to diagnose 90% of people living with HIV, put 90% of them on treatment, and for 90% of them to have suppressed viral load have focused the international HIV response on the goal of eliminating HIV by 2030. They are also a constructive tool for measuring progress toward reaching this goal but their utility is dependent upon data availability. Though more than 25% of new infections are among key populations (KP)- sex workers, men who have sex with men, transgender people, people who inject drugs, and prisoners- and their sex partners, there is a dearth of treatment cascade data for KP...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30033644/what-would-you-choose-online-or-offline-or-mixed-services-feasibility-of-online-hiv-counselling-and-testing-among-thai-men-who-have-sex-with-men-and-transgender-women-and-factors-associated-with-service-uptake
#19
Nittaya Phanuphak, Tarandeep Anand, Jureeporn Jantarapakde, Chattiya Nitpolprasert, Kanittha Himmad, Thanthip Sungsing, Deondara Trachunthong, Sangusa Phomthong, Petchfa Phoseeta, Sumitr Tongmuang, Pravit Mingkwanrungruang, Dusita Meekrua, Supachai Sukthongsa, Somporn Hongwiangchan, Nutchanin Upanun, Jiranuwat Barisri, Tippawan Pankam, Praphan Phanuphak
INTRODUCTION: HIV testing coverage remains low among men who have sex with men (MSM) and transgender women (TGW). We studied characteristics of Thai MSM and TGW who chose online and/or offline platforms for HIV counselling and testing and the feasibility of integrating online technologies and HIV self-testing to create service options. METHODS: From December 2015 to June 2017, MSM and TGW enrolled from Bangkok Metropolitan Region and Pattaya could choose between: offline HIV counselling and testing (Offline group), online pre-test counselling and offline HIV testing (Mixed group), and online counselling and online, supervised, HIV self-testing (Online group)...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30033612/self-testing-communication-and-information-technology-to-promote-hiv-diagnosis-among-young-gay-and-other-men-who-have-sex-with-men-msm-in-brazil
#20
Raquel B De Boni, Nena Lentini, Ana Cfs Santelli, Aristides Barbosa, Marly Cruz, Trista Bingham, Vanda Cota, Renato Girade Correa, Valdiléa G Veloso, Beatriz Grinsztejn
No abstract text is available yet for this article.
July 2018: Journal of the International AIDS Society
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