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Journal of the International AIDS Society

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https://www.readbyqxmd.com/read/29334197/increased-non-aids-mortality-among-persons-with-aids-defining-events-after-antiretroviral-therapy-initiation
#1
April C Pettit, Mark J Giganti, Suzanne M Ingle, Margaret T May, Bryan E Shepherd, Michael J Gill, Gerd Fätkenheuer, Sophie Abgrall, Michael S Saag, Julia Del Amo, Amy C Justice, Jose M Miro, Matthias Cavasinni, François Dabis, Antonella D Monforte, Peter Reiss, Jodie Guest, David Moore, Leah Shepherd, Niels Obel, Heidi M Crane, Colette Smith, Ramon Teira, Robert Zangerle, Jonathan Ac Sterne, Timothy R Sterling
INTRODUCTION: HIV-1 infection leads to chronic inflammation and to an increased risk of non-AIDS mortality. Our objective was to determine whether AIDS-defining events (ADEs) were associated with increased overall and cause-specific non-AIDS related mortality after antiretroviral therapy (ART) initiation. METHODS: We included HIV treatment-naïve adults from the Antiretroviral Therapy Cohort Collaboration (ART-CC) who initiated ART from 1996 to 2014. Causes of death were assigned using the Coding Causes of Death in HIV (CoDe) protocol...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29334191/exogenous-oestrogen-inhibits-genital-transmission-of-cell-associated-hiv-1-in-dmpa-treated-humanized-mice
#2
Nirk E Quispe Calla, Rodolfo D Vicetti Miguel, Melissa E Glick, Jesse J Kwiek, Janelle M Gabriel, Thomas L Cherpes
INTRODUCTION: HIV affects more women than any other life-threatening infectious agent, and most infections are sexually transmitted. HIV must breach the female genital tract mucosal barrier to establish systemic infection, and clinical studies indicate virus more easily evades this barrier in women using depot-medroxyprogesterone acetate (DMPA) and other injectable progestins for contraception. Identifying a potential mechanism for this association, we learned DMPA promotes susceptibility of wild-type mice to genital herpes simplex virus type 2 (HSV-2) infection by reducing genital tissue expression of the cell-cell adhesion molecule desmoglein-1 (DSG-1) and increasing genital mucosal permeability...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29334178/factors-associated-with-perceived-accuracy-of-the-undetectable%C3%A2-%C3%A2-untransmittable-slogan-among-men-who-have-sex-with-men-implications-for-messaging-scale-up-and-implementation
#3
H Jonathon Rendina, Jeffrey T Parsons
INTRODUCTION: Recent research has shown high efficacy of HIV treatment for reducing the risk of HIV transmission to sexual partners. As the efficacy of treatment as prevention (TasP) has proliferated, a new messaging campaign, Undetectable = Untransmittable, has been gaining popularity. The purpose of this paper was to assess factors associated with the perceived accuracy of this TasP messaging strategy among a large and diverse sample of gay, bisexual, and other men who have sex with men (GBMSM) in order to inform subsequent efforts at large-scale and implementation of the HIV prevention message...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29327442/transplantation-or-rurality-migration-and-hiv-risk-among-chinese-men-who-have-sex-with-men-in-the-urban-areas
#4
Chuncheng Liu, Rong Fu, Weiming Tang, Bolin Cao, Stephen W Pan, Chongyi Wei, Joseph D Tucker, M Kumi Smith
INTRODUCTION: Migration of men who have sex with men (MSM) from rural to urban areas is common across low- and middle-income countries and is widely believed to contribute to elevated HIV risk among migrant MSM in urban areas. Little consensus exists on whether their risk is due to their transplantation or their being from resource-constrained rural areas. This study seeks to clarify the relationship between migration and HIV risks by comparing differences in HIV-related risky sexual behaviours and healthcare utilization across competing conceptualizations of migratory statuses...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29314670/eliminating-hepatitis-c-virus-as-a-public-health-threat-among-hiv-positive-men-who-have-sex-with-men-a-multi-modelling-approach-to-understand-differences-in-sexual-risk-behaviour
#5
Nick Scott, Mark Stoové, David P Wilson, Olivia Keiser, Carol El-Hayek, Joseph Doyle, Margaret Hellard
INTRODUCTION: Outbreaks of hepatitis C virus (HCV) infections among HIV-positive men who have sex with men (MSM) have been observed globally. Using a multi-modelling approach we estimate the time and number of direct-acting antiviral treatment courses required to achieve an 80% reduction in HCV prevalence among HIV-positive MSM in the state of Victoria, Australia. METHODS: Three models of HCV transmission, testing and treatment among MSM were compared: a dynamic compartmental model; an agent-based model (ABM) parametrized to local surveillance and behavioural data ("ABM1"); and an ABM with a more heterogeneous population ("ABM2") to determine the influence of extreme variations in sexual risk behaviour...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29314658/comparative-assessment-of-five-trials-of-universal-hiv-testing-and-treatment-in-sub-saharan-africa
#6
REVIEW
Delphine Perriat, Laura Balzer, Richard Hayes, Shahin Lockman, Fiona Walsh, Helen Ayles, Sian Floyd, Diane Havlir, Moses Kamya, Refeletswe Lebelonyane, Lisa A Mills, Velephi Okello, Maya Petersen, Deenan Pillay, Kalpana Sabapathy, Kathleen Wirth, Joanna Orne-Gliemann, François Dabis
DESIGN: Universal voluntary HIV counselling and testing followed by prompt initiation of antiretroviral therapy (ART) for all those diagnosed HIV-infected (universal test and treat, UTT) is now a global health standard. However, its population-level impact, feasibility and cost remain unknown. Five community-based trials have been implemented in sub-Saharan Africa to measure the effects of various UTT strategies at population level: BCPP/YaTsie in Botswana, MaxART in Swaziland, HPTN 071 (PopART) in South Africa and Zambia, SEARCH in Uganda and Kenya and ANRS 12249 TasP in South Africa...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29285883/associations-between-friendship-characteristics-and-hiv-and-hsv-2-status-amongst-young-south-african-women-in-hptn-068
#7
Elizabeth Fearon, Richard D Wiggins, Audrey E Pettifor, Catherine MacPhail, Kathleen Kahn, Amanda Selin, F Xavier Gómez-Olivé, Sinéad Delany-Moretlwe, Estelle Piwowar-Manning, Oliver Laeyendecker, James R Hargreaves
INTRODUCTION: Prevalence of HIV among young women in South Africa remains extremely high. Adolescent peer groups have been found to be an important influence on a range of health behaviours. The characteristics of young women's friendships might influence their sexual health and HIV risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. We investigated associations between young women's friendships and their Herpes Simplex Virus Type 2 (HSV-2) and HIV infection status in rural South Africa...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29282882/recent-progress-in-immune-based-interventions-to-prevent-hiv-1-transmission-to-children
#8
Yegor Voronin, Ilesh Jani, Barney S Graham, Coleen K Cunningham, Lynne M Mofenson, Philippa M Musoke, Sallie R Permar, Gabriella Scarlatti
Globally, 150,000 new paediatric human immunodeficiency virus type 1 (HIV-1) infections occurred in 2015. There remain complex challenges to the global elimination of paediatric HIV-1 infection. Thus, for the global community to achieve elimination of new paediatric HIV-1 infections, innovative approaches need to be explored. Immune-based approaches to prevention of mother-to-child transmission (MTCT) may help fill some of the remaining gaps and provide new opportunities to achieve an AIDS-free generation. Immune-based interventions to prevent MTCT of HIV-1 may include paediatric HIV vaccines and passive immunization approaches...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29251433/predictors-of-timely-linkage-to-art-within-universal-test-and-treat-in-the-hptn-071-popart-trial-in-zambia-and-south-africa-findings-from-a-nested-case-control-study
#9
Kalpana Sabapathy, Constance Mubekapi-Musadaidzwa, Chama Mulubwa, Ab Schaap, Graeme Hoddinott, Anne Stangl, Sian Floyd, Helen Ayles, Sarah Fidler, Richard Hayes
INTRODUCTION: HPTN 071 (PopART) is a three-arm community randomized trial in Zambia and South Africa evaluating the impact of a combination HIV prevention package, including universal test and treat (UTT), on HIV incidence. This nested study examined factors associated with timely linkage-to-care and ART initiation (TLA) (i.e. within six-months of referral) in the context of UTT within the intervention communities of the HPTN 071 (PopART) trial. METHODS: Of the 7572 individuals identified as persons living with HIV (PLWH) (and not on antiretroviral treatment (ART)) during the first year of the PopART intervention provided by Community HIV-care Providers (CHiPs) through door-to-door household visits, individuals who achieved TLA (controls) and those who did not (cases), stratified by gender and community, were randomly selected to be re-contacted for interview...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29244242/erratum
#10
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29243388/the-treatment-outcomes-of-antiretroviral-substitutions-in-routine-clinical-settings-in-asia-data-from-the-treat-asia-hiv-observational-database-tahod
#11
In Young Jung, David Boettiger, Wing Wai Wong, Man Po Lee, Sasisopin Kiertiburanakul, Romanee Chaiwarith, Anchalee Avihingsanon, Junko Tanuma, Nagalingeswaran Kumarasamy, Adeeba Kamarulzaman, Fujie Zhang, Pacharee Kantipong, Oon Tek Ng, Benedict Lim Heng Sim, Matthew Law, Jeremy Ross, Jun Yong Choi
INTRODUCTION: Although substitutions of antiretroviral regimen are generally safe, most data on substitutions are based on results from clinical trials. The objective of this study was to evaluate the treatment outcomes of substituting antiretroviral regimen in virologically suppressed HIV-infected patients in non-clinical trial settings in Asian countries. METHODS: The study population consisted of HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD)...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29236362/implementation-of-repeat-hiv-testing-during-pregnancy-in-southwestern-kenya-progress-and-missed-opportunities
#12
Anna J Rogers, Eliud Akama, Elly Weke, Justin Blackburn, George Owino, Elizabeth A Bukusi, Patrick Oyaro, Zachary A Kwena, Craig R Cohen, Janet M Turan
INTRODUCTION: Repeat HIV testing during the late antenatal period is crucial to identify and initiate treatment for pregnant women with incident HIV infection to prevent perinatal HIV transmission and keep mothers alive. In 2012, the Kenya Ministry of Health adopted international guidelines suggesting that pregnant women be offered retesting three months after an initial negative HIV test. Our objectives were to determine the current rate of antenatal repeat HIV testing; identify successes, missed opportunities and factors associated with retesting; and estimate the incidence of HIV during pregnancy...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29232052/the-us-food-and-drug-administration-s-tentative-approval-process-and-the-global-fight-against-hiv
#13
Harinder Singh Chahal, Jeffrey S Murray, Martin Shimer, Peter Capella, Ryan Presto, Mary Lou Valdez, Peter G Lurie
INTRODUCTION: In 2004, the US government began to utilize the Food and Drug Administration's (USFDA) tentative approval process (tFDA) as a basis to determine which HIV drugs are appropriate to be purchased and used in resource-constrained settings. This process permits products that are not approved for marketing in the US, including medicines with active patents or marketing restrictions in the US, to be purchased and distributed in resource-constrained settings. Although the tFDA was originally intended to support the United States' President's Emergency Plan for AIDS Relief (PEPFAR), the USFDA list has become a cornerstone of international HIV programmes that support procurement of ARVs, such as the World Health Organization and the Global Fund to Fight AIDS, Tuberculosis, and Malaria...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29220115/hiv-prevention-where-it-is-needed-most-comparison-of-strategies-for-the-geographical-allocation-of-interventions
#14
Sarah-Jane Anderson, Peter D Ghys, Regina Ombam, Timothy B Hallett
INTRODUCTION: A strategic approach to the application of HIV prevention interventions is a core component of the UNAIDS Fast Track strategy to end the HIV epidemic by 2030. Central to these plans is a focus on high-prevalence geographies, in a bid to target resources to those in greatest need and maximize the reduction in new infections. Whilst this idea of geographical prioritization has the potential to improve efficiency, it is unclear how it should be implemented in practice. There are a range of prevention interventions which can be applied differentially across risk groups and locations, making allocation decisions complex...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29219248/-my-mother-told-me-that-i-should-not-a-qualitative-study-exploring-the-restrictions-placed-on-adolescent-girls-living-with-hiv-in-zambia
#15
Constance Rs Mackworth-Young, Virginia Bond, Alison Wringe, Katongo Konayuma, Sue Clay, Chipo Chiiya, Mutale Chonta, Kirsty Sievwright, Anne L Stangl
INTRODUCTION: Adolescent girls in sub-Saharan Africa are disproportionately affected by HIV due to a range of social and structural factors. As they transition to adulthood, they are recipients of increasing blame for HIV infection and 'improper' sex, as well as increasing scrutiny, restrictions and surveillance. This study used a qualitative and participatory approach to explore the messaging and restrictions imposed on adolescent girls living with HIV in Zambia. METHODS: Thirty-four in-depth interviews and four participatory workshops were carried out with 24 adolescent girls aged 15 to 19 years old living with HIV in Lusaka, Zambia...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29211347/long-term-viral-suppression-and-immune-recovery-during-first-line-antiretroviral-therapy-a-study-of-an-hiv-infected-adult-cohort-in-hanoi-vietnam
#16
Junko Tanuma, Shoko Matsumoto, Sebastien Haneuse, Do Duy Cuong, Tuong Van Vu, Pham Thi Thanh Thuy, Nguyen Thi Dung, Nguyen Thi Hoai Dung, Nguyen Vu Trung, Nguyen Van Kinh, Shinichi Oka
INTRODUCTION: Achieving viral suppression is key in the global strategy to end the HIV epidemic. However, the levels of viral suppression have yet to be described in many resource-limited settings. METHODS: We investigated the time to virologic failure (VF; defined as a viral load of ≥1000 copies/ml) and changes in CD4 counts since starting antiretroviral therapy (ART) in a cohort of HIV-infected adults in Hanoi, Vietnam. Factors related to the time to VF and impaired early immune recovery (defined as not attaining an increase in 100 cells/mm3 in CD4 counts at 24 months) were further analysed...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29210185/redemption-of-the-spoiled-identity-the-role-of-hiv-positive-individuals-in-hiv-care-cascade-interventions
#17
Carol S Camlin, Edwin D Charlebois, Elvin Geng, Fred Semitala, Jeanna Wallenta, Monica Getahun, Leatitia Kampiire, Elizabeth A Bukusi, Norton Sang, Dalsone Kwarisiima, Tamara D Clark, Maya L Petersen, Moses R Kamya, Diane V Havlir
INTRODUCTION: The concept of "therapeutic citizenship" has drawn attention to ways in which public testimony, the "story-telling in the public sphere" undertaken by people living with HIV (PLHIV), has shaped the global response to the epidemic. This paper presents qualitative findings from two large studies in eastern Africa that reveal how the advent of population-based HIV testing campaigns and efforts to accelerate antiretroviral "treatment for all" has precipitated a rapidly expanding therapeutic citizenship "project," or social movement...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29206357/understanding-uptake-of-an-intervention-to-accelerate-antiretroviral-therapy-initiation-in-uganda-via-qualitative-inquiry
#18
Fred C Semitala, Carol S Camlin, Jeanna Wallenta, Leatitia Kampiire, Richard Katuramu, Gideon Amanyire, Jennifer Namusobya, Wei Chang, James G Kahn, Edwin D Charlebois, Diane V Havlir, Moses R Kamya, Elvin H Geng
INTRODUCTION: The Streamlined Antiretroviral Therapy Initiation Strategy (START-ART) study found that a theory-based intervention using opinion leaders to inform and coach health care providers about the risks of treatment delay, provision of point of care (POC) CD4 testing machines (PIMA) and reputational incentives, led to rapid rise in ART initiation. We used qualitative research methods to explore mechanisms of provider behaviour change. METHODS: We conducted in-depth interviews (IDIs) with 24 health care providers and nine study staff to understand perceptions, attitudes and the context of changes in ART initiation practices...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29178578/trends-in-maternal-deaths-in-hiv-infected-women-on-a-background-of-changing-hiv-management-guidelines-in-south-africa-1997-to-2015
#19
Coceka N Mnyani, Eckhart J Buchmann, Matthew F Chersich, Karlyn A Frank, James A McIntyre
INTRODUCTION: As work begins towards the Sustainable Development Goal target of reducing the global maternal mortality ratio (MMR) to less than 70 deaths per 100,000 live births by 2030, much needs to be done in ending preventable maternal deaths. After 1990, South Africa experienced a reversal of gains in decreasing maternal mortality, with an increase in HIV-related maternal deaths. In this study, we assessed trends in maternal mortality in HIV-infected women, on a background of an evolving HIV care programme...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29178197/greater-retention-in-care-among-adolescents-on-antiretroviral-treatment-accessing-teen-club-an-adolescent-centred-differentiated-care-model-compared-with-standard-of-care-a-nested-case-control-study-at-a-tertiary-referral-hospital-in-malawi
#20
Rachel K MacKenzie, Monique van Lettow, Chrissie Gondwe, James Nyirongo, Victor Singano, Victor Banda, Edith Thaulo, Teferi Beyene, Mansi Agarwal, Allyson McKenney, Susan Hrapcak, Daniela Garone, Sumeet K Sodhi, Adrienne K Chan
INTRODUCTION: There are numerous barriers to the care and support of adolescents living with HIV (ALHIV) that makes this population particularly vulnerable to attrition from care, poor adherence and virological failure. In 2010, a Teen Club was established in Zomba Central Hospital (ZCH), Malawi, a tertiary referral HIV clinic. Teen Club provides ALHIV on antiretroviral treatment (ART) with dedicated clinic time, sexual and reproductive health education, peer mentorship, ART refill and support for positive living and treatment adherence...
November 2017: Journal of the International AIDS Society
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