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Journal of the International AIDS Society

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https://www.readbyqxmd.com/read/28715160/meeting-the-who-90-target-antiretroviral-treatment-efficacy-in-poland-is-associated-with-baseline-clinical-patient-characteristics
#1
Milosz Parczewski, Ewa Siwak, Magdalena Leszczyszyn-Pynka, Iwona Cielniak, Ewa Burkacka, Piotr Pulik, Adam Witor, Karolina Muller, Ewelina Zasik, Anna Grzeszczuk, Maria Jankowska, Małgorzata Lemańska, Anita Olczak, Edyta Grąbczewska, Aleksandra Szymczak, Jacek Gąsiorowski, Bartosz Szetela, Monika Bociąga-Jasik, Paweł Skwara, Magdalena Witak-Jędra, Elżbieta Jabłonowska, Kamila Wójcik-Cichy, Juliusz Kamerys, Małgorzata Janczarek, Dagny Krankowska, Tomasz Mikuła, Katarzyna Kozieł, Dariusz Bielec, Justyna Stempkowska, Aleksandra Kocbach, Wiesława Błudzin, Andrzej Horban
INTRODUCTION: Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV-1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral treatment efficacy in Poland and to identify variables associated with virologic suppression. M: ethods Cross-sectional data on 5152 (56.92% of the countrywide treated at the time-point of analysis) patients on cART for more than six months with at least one HIV-RNA measurement in 2016 were collected from 14 Polish centres...
July 17, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28715159/alcohol-antiretroviral-interactive-toxicity-beliefs-as-a-potential-barrier-to-hiv-pre-exposure-prophylaxis-among-men-who-have-sex-with-men
#2
Seth C Kalichman, Lisa Eaton
INTRODUCTION: Pre-exposure prophylaxis (PrEP) offers as much as 90% protection against HIV transmission. However, the effectiveness of PrEP depends on uptake and adherence to even intermittent dosing. Along with intoxication leading to unintentional non-adherence, believing that alcohol mixed with pharmaceuticals is harmful (i.e., interactive toxicity beliefs) may lead to poor uptake and intentional non-adherence. METHODS: HIV-negative sexually active men who have sex with men (N = 272) at a large Gay Pride event in Atlanta, GA, completed anonymous surveys of demographic characteristics, sexual behaviour, alcohol use and PrEP-related alcohol interactive toxicity beliefs...
July 17, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28715158/loss-to-follow-up-among-children-and-adolescents-growing-up-with-hiv-infection-age-really-matters
#3
Katharina Kranzer, John Bradley, Joseph Musaazi, Mary Nyathi, Hilary Gunguwo, Wedu Ndebele, Mark Dixon, Mbongeni Ndhlovu, Andrea Rehman, Palwasha Khan, Florian Vogt, Tsitsi Apollo, Rashida Abbas Ferrand
INTRODUCTION: Globally, increasing numbers of HIV-infected children are reaching adolescence due to antiretroviral therapy (ART). We investigated rates of loss-to-follow-up (LTFU) from HIV care services among children as they transition from childhood through adolescence. METHODS: Individuals aged 5-19 years initiated on ART in a public-sector HIV clinic in Bulawayo, Zimbabwe, between 2005 and 2009 were included in a retrospective cohort study. Participants were categorized into narrow age-bands namely: 5-9 (children), 10-14 (young adolescents) and 15-19 (older adolescents)...
July 17, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28715157/use-of-the-shangring-circumcision-device-in-boys-below-18-years-old-in-kenya-results-from-a-pilot-study
#4
Quentin D Awori, Richard K Lee, Phillip S Li, Jared N Moguche, Dan Ouma, Betsy Sambai, Marc Goldstein, Mark A Barone
INTRODUCTION: Male circumcision is a proven prevention strategy against the spread of HIV. The World Health Organization's new 2016-2021 strategic framework on voluntary medical male circumcision (VMMC) targets 90% of males aged 10-29 years to receive circumcision by 2021 in 14 priority sub-Saharan countries while anticipating an increase in the demand for infant circumcision. It also states that the use of circumcision devices is a safe and efficient innovation to accelerate attainment of these goals...
July 12, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28692210/agency-as-a-mediator-in-the-pathway-from-transactional-sex-to-hiv-among-pregnant-women-in-swaziland-a-multigroup-path-analysis
#5
Rebecca Fielding-Miller, Kristin L Dunkle, Craig Hadley, Hannah Lf Cooper, Michael Windle
INTRODUCTION: Transactional sex is a structural driver of HIV for women and girls in sub-Saharan Africa. In transactional relationships, sexual and economic obligations intertwine and may have positive and negative effects on women's financial standing and social status. We conducted a clinic-based survey with pregnant women in Swaziland using a locally validated transactional sex scale to measure the association between subjective social status, transactional sex, and HIV status, and to assess whether this association differed according to a woman's agency within her relationship...
July 7, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691437/hiv-misdiagnosis-in-sub-saharan-africa-performance-of-diagnostic-algorithms-at-six-testing-sites
#6
REVIEW
Cara S Kosack, Leslie Shanks, Greet Beelaert, Tumwesigye Benson, Aboubacar Savane, Anne Ng'ang'a, Bita Andre, Jean-Paul Bn Zahinda, Katrien Fransen, Anne-Laure Page
INTRODUCTION: We evaluated the diagnostic accuracy of HIV testing algorithms at six programmes in five sub-Saharan African countries. METHODS: In this prospective multisite diagnostic evaluation study (Conakry, Guinea; Kitgum, Uganda; Arua, Uganda; Homa Bay, Kenya; Doula, Cameroun and Baraka, Democratic Republic of Congo), samples from clients (greater than equal to five years of age) testing for HIV were collected and compared to a state-of-the-art algorithm from the AIDS reference laboratory at the Institute of Tropical Medicine, Belgium...
July 3, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28692209/the-science-of-durban-aids-2016
#7
Chris Beyrer, Olive Shisana, Stefan D Baral, Koleka Milsana, Kenneth H Mayer, Anton Pozniak, Bruce D Walker, Souleman Mboup, Annette H Sohn, David Serwadda, Helen Rees, Sergii Dvoriak, Mitchell Warren, Safiatou Thiam, Wafaa M El-Sadr, Xavier Hospital, Owen Ryan, Nicolas Thomson, Linda-Gail Bekker
INTRODUCTION: The science presented at the 21st International AIDS Conference in Durban, South Africa, in July 2016, addressed the state of the field across basic, clinical, prevention, law and policy and implementation science. METHODS AND RESULTS: The AIDS response has seen remarkable achievements in scientific advances, in translation of those advances into prevention, treatment and care for affected individuals and communities, and in large scale implementation - reaching 18 million people with antiviral therapy by mid-year 2016...
June 30, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28692208/hcv-antigen-instead-of-rna-testing-to-diagnose-acute-hcv-in-patients-treated-in-the-dutch-acute-hcv-in-hiv-study
#8
Sebastiaan J Hullegie, Corine H GeurtsvanKessel, Annemiek A van der Eijk, Chris Ramakers, Bart J A Rijnders
INTRODUCTION: Affordable and sensitive screening methods for acute hepatitis C (HCV) are necessary to successfully intervene in the current HCV epidemic among HIV-positive men having sex with men. HCV core antigen (Ag) testing has been proven effective in diagnosing chronic HCV-infected patients at low costs. We studied the characteristics of HCV Ag testing in acute HCV-infected HIV-positive patients. Methods Plasma samples were selected from acutely HCV genotype 1-infected patients treated with peginterferon, ribavirin and boceprevir in the Dutch Acute HCV in HIV Study...
June 30, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691441/acute-hiv-infection-detection-and-immediate-treatment-estimated-to-reduce-transmission-by-89-among-men-who-have-sex-with-men-in-bangkok
#9
Eugène D M B Kroon, Nittaya Phanuphak, Andrew J Shattock, James L K Fletcher, Suteeraporn Pinyakorn, Nitiya Chomchey, Siriwat Akapirat, Mark S de Souza, Merlin L Robb, Jerome H Kim, Frits van Griensven, Jintanat Ananworanich, David P Wilson
INTRODUCTION: Antiretroviral treatment (ART) reduces HIV transmission. Despite increased ART coverage, incidence remains high among men who have sex with men (MSM) in many places. Acute HIV infection (AHI) is characterized by high viral replication and increased infectiousness. We estimated the feasible reduction in transmission by targeting MSM with AHI for early ART. METHODS: We recruited a cohort of 88 MSM with AHI in Bangkok, Thailand, who initiated ART immediately...
June 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691440/high-risk-of-loss-to-follow-up-among-south-african-children-on-art-during-transfer-a-retrospective-cohort-analysis-with-community-tracing
#10
Chloe A Teasdale, Nonzwakazi Sogaula, Katharine A Yuengling, Zachary J Peters, Anthony Mutiti, Lungile Pepeta, Elaine J Abrams
INTRODUCTION: Decentralization of HIV care for children has been recommended to improve paediatric outcomes by making antiretroviral treatment (ART) more accessible. We documented outcomes of children transferred after initiating ART at a large tertiary hospital in the Eastern Cape of South Africa. METHODS: Electronic medical records for all children 0-15 years initiating ART at Dora Nginza Hospital (DNH) in Port Elizabeth, South Africa January 2004 to September 2015 were examined...
June 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691435/clinical-and-public-health-implications-of-acute-and-early-hiv-detection-and-treatment-a-scoping-review
#11
Sarah E Rutstein, Jintanat Ananworanich, Sarah Fidler, Cheryl Johnson, Eduard J Sanders, Omar Sued, Asier Saez-Cirion, Christopher D Pilcher, Christophe Fraser, Myron S Cohen, Marco Vitoria, Meg Doherty, Joseph D Tucker
INTRODUCTION: The unchanged global HIV incidence may be related to ignoring acute HIV infection (AHI). This scoping review examines diagnostic, clinical, and public health implications of identifying and treating persons with AHI. METHODS: We searched PubMed, in addition to hand-review of key journals identifying research pertaining to AHI detection and treatment. We focused on the relative contribution of AHI to transmission and the diagnostic, clinical, and public health implications...
June 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691433/taking-a-critical-look-at-the-unaids-global-estimates-on-paediatric-and-adolescent-hiv-survival-and-death
#12
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691434/universal-antiretroviral-therapy-for-hiv-infected-children-a-review-of-the-benefits-and-risks-to-consider-during-implementation
#13
Linda Barlow-Mosha, Victor Musiime, Mary-Ann Davies, Andrew J Prendergast, Philippa Musoke, George Siberry, Martina Penazzato
BACKGROUND: The 2016 World Health Organization (WHO) consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection, recommended to start all HIV-infected children on antiretroviral therapy (ART). Here, we explore the possible benefits and risks of implementing universal ART for all HIV-infected children and adolescents and outline some of the key considerations that led to the 2016 revision of WHO guidelines. METHODS: We conducted a review of the published data from 2000 to 2016, to ascertain the clinical and programmatic benefits, as well as the risks of implementing universal ART for all children...
June 27, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691442/acceptability-of-woman-delivered-hiv-self-testing-to-the-male-partner-and-additional-interventions-a-qualitative-study-of-antenatal-care-participants-in-malawi
#14
Augustine Talumba Choko, Moses Kelly Kumwenda, Cheryl Case Johnson, Doreen Wongera Sakala, Maria Chifuniro Chikalipo, Katherine Fielding, Jeremiah Chikovore, Nicola Desmond, Elizabeth Lucy Corbett
INTRODUCTION: In the era of ambitious HIV targets, novel HIV testing models are required for hard-to-reach groups such as men, who remain underserved by existing services. Pregnancy presents a unique opportunity for partners to test for HIV, as many pregnant women will attend antenatal care (ANC). We describe the views of pregnant women and their male partners on HIV self-test kits that are woman-delivered, alone or with an additional intervention. METHODS: A formative qualitative study to inform the design of a multi-arm multi-stage cluster-randomized trial, comprised of six focus group discussions and 20 in-depth interviews, was conducted...
June 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691439/awareness-and-willingness-to-use-hiv-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis
#15
Siyan Yi, Sovannary Tuot, Grace W Mwai, Chanrith Ngin, Kolab Chhim, Khoundyla Pal, Ewemade Igbinedion, Paula Holland, Sok Chamreun Choub, Gitau Mburu
INTRODUCTION: To facilitate provision of pre-exposure prophylaxis (PrEP) in low- and middle-income countries (LMIC), a better understanding of potential demand and user preferences is required. This review assessed awareness and willingness to use oral PrEP among men who have sex with men (MSM) in LMIC. METHODS: Electronic literature search of Cochrane library, Embase, PubMed, PsychINFO, CINHAL, Web of Science, and Google Scholar was conducted between July and September 2016...
June 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691436/viral-kinetics-in-untreated-versus-treated-acute-hiv-infection-in-prospective-cohort-studies-in-thailand
#16
Jintanat Ananworanich, Leigh Anne Eller, Suteeraporn Pinyakorn, Eugene Kroon, Somchai Sriplenchan, James Lk Fletcher, Duanghathai Suttichom, Christopher Bryant, Rapee Trichavaroj, Peter Dawson, Nelson Michael, Nittaya Phanuphak, Merlin L Robb
INTRODUCTION: The extent of viral replication during acute HIV infection (AHI) influences HIV disease progression. However, information comparing viral load (VL) kinetics with and without antiretroviral therapy (ART) in AHI is limited. The knowledge gained could inform preventive strategies aimed at reducing VL during AHI and therapeutic strategies to alter the viral kinetics that may enhance the likelihood of achieving HIV remission. METHODS: The analysis utilized VL data captured during the first year of HIV infection from two studies in Thailand: the RV217 study (untreated AHI, 30 participants and 412 visits) and the RV254 study (treated AHI, 235 participants and 2803 visits)...
June 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691438/hiv-viral-load-as-an-independent-risk-factor-for-tuberculosis-in-south-africa-collaborative-analysis-of-cohort-studies
#17
Lukas Fenner, Andrew Atkinson, Andrew Boulle, Matthew P Fox, Hans Prozesky, Kathrin Zürcher, Marie Ballif, Hansjakob Furrer, Marcel Zwahlen, Mary-Ann Davies, Matthias Egger
INTRODUCTION: Chronic immune activation due to ongoing HIV replication may lead to impaired immune responses against opportunistic infections such as tuberculosis (TB). We studied the role of HIV replication as a risk factor for incident TB after starting antiretroviral therapy (ART). METHODS: We included all HIV-positive adult patients (≥16 years) in care between 2000 and 2014 at three ART programmes in South Africa. Patients with previous TB were excluded. Missing CD4 cell counts and HIV-RNA viral loads at ART start (baseline) and during follow-up were imputed...
June 23, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28664683/alert-but-not-alarmed-a-comment-on-towards-more-accurate-hiv-testing-in-sub-saharan-africa-a-multi-site-evaluation-of-hiv-rdts-and-risk-factors-for-false-positives-kosack-et-al-2017
#18
LETTER
Cheryl C Johnson, Anita Sands, Willy Urassa, Rachel Baggaley
No abstract text is available yet for this article.
June 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28664682/response-to-comment-on-alert-but-not-alarmed-a-comment-on-towards-more-accurate-hiv-testing-in-sub-saharan-africa-a-multi-site-evaluation-of-hiv-rdts-and-risk-factors-for-false-positives-kosack-et-al-2017
#19
LETTER
Cara S Kosack, Anne-Laure Page, Greet Beelaert, Tumwesigye Benson, Aboubacar Savane, Anne Ng'ang'a, Bita Andre, Jean-Paul Bn Zahinda, Leslie Shanks, Katrien Fransen
No abstract text is available yet for this article.
June 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28664684/cross-cultural-assessment-of-hiv-associated-cognitive-impairment-using-the-kaufman-assessment-battery-for-children-a-systematic-review
#20
Kaylee S van Wyhe, Tanya van de Water, Michael J Boivin, Mark F Cotton, Kevin Gf Thomas
INTRODUCTION: Despite improved efficacy of, and access to, combination antiretroviral therapy (cART), HIV-associated cognitive impairments remain prevalent in both children and adults. Neuropsychological tests that detect such impairment can help clinicians formulate effective treatment plans. The Kaufman Assessment Battery for Children (KABC), although developed and standardized in the United States, is used frequently in many different countries and cultural contexts to assess paediatric performance across various cognitive domains...
June 14, 2017: Journal of the International AIDS Society
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