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Journal of the International AIDS Society

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https://www.readbyqxmd.com/read/28812339/young-people-hiv-and-life-goals
#1
REVIEW
Kathleen M MacQueen
No abstract text is available yet for this article.
August 14, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28799325/comparison-between-next-generation-and-sanger-based-sequencing-for-the-detection-of-transmitted-drug-resistance-mutations-among-recently-infected-hiv-1-patients-in-israel-2000-2014
#2
Roy Moscona, Daniela Ram, Marina Wax, Efrat Bucris, Itzchak Levy, Ella Mendelson, Orna Mor
INTRODUCTION: Transmitted drug-resistance mutations (TDRM) may hamper successful anti-HIV-1 therapy and impact future control of the HIV-1 epidemic. Recently infected, therapy-naïve individuals are best suited for surveillance of such TDRM. In this study, TDRM, detected by next-generation sequencing (NGS) were compared to those identified by Sanger-based population sequencing (SBS) in recently infected HIV-1 patients. METHODS: Historical samples from 80 recently infected HIV-1 patients, diagnosed between 2000 and 2014, were analysed by MiSeq (NGS) and ABI (SBS)...
August 11, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28799324/reviewing-independent-access-to-hiv-testing-counselling-and-treatment-for-adolescents-in-hiv-specific-laws-in-sub-saharan-africa-implications-for-the-hiv-response
#3
Patrick M Eba, HyeYoung Lim
INTRODUCTION: AIDS is a leading cause of death among adolescents in sub-Saharan Africa. Yet, legal, policy and social barriers continue to restrict their access to HIV services. In recent years, access to independent HIV testing and treatment for adolescents has gained increased attention. The 2013 WHO Guidance on HIV testing and counselling and care for adolescents living with HIV (WHO Guidance) calls for reviewing legal and regulatory frameworks to facilitate adolescents' access to comprehensive HIV services...
August 11, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28782334/pregnant-adolescents-living-with-hiv-what-we-know-what-we-need-to-know-where-we-need-to-go
#4
Tegan Callahan, Surbhi Modi, Jennifer Swanson, Bernadette Ng'eno, Laura N Broyles
INTRODUCTION: HIV-infected pregnant and breastfeeding adolescents are a particularly vulnerable group that require special attention and enhanced support to achieve optimal maternal and infant outcomes. The objective of this paper is to review published evidence about antenatal care (ANC) service delivery and outcomes for HIV-infected pregnant adolescents in low-income country settings, identify gaps in knowledge and programme services and highlight the way forward to improve clinical outcomes of this vulnerable group...
August 4, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28782336/willingness-to-use-pre-exposure-prophylaxis-prep-for-hiv-prevention-among-men-who-have-sex-with-men-msm-in-malaysia-findings-from-a-qualitative-study
#5
Adam Bourne, Matteo Cassolato, Clayton Koh Thuan Wei, Bangyuan Wang, Joselyn Pang, Sin How Lim, Iskandar Azwa, Ilias Yee, Gitau Mburu
BACKGROUND: Men who have sex with men (MSM) continue to be disproportionately affected by HIV in Malaysia. Recent success has been observed within demonstration projects examining the efficacy of HIV pre-exposure prophylaxis (PrEP), an antiretroviral -based medication taken by HIV-negative men to prevent sero-conversion. In order for such promising findings to be translated in real-world settings, it is important to understand the acceptability of PrEP, including perceived barriers to access or uptake...
August 2, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28782331/acceptability-of-a-microfinance-based-empowerment-intervention-for-transgender-and-cisgender-women-sex-workers-in-greater-kuala-lumpur-malaysia
#6
Priya Lall, Stacey A Shaw, Rumana Saifi, Susan Sherman, Nuruljannah Nor Azmi, Veena Pillai, Nabila El-Bassel, Adeeba Kamarulzaman, Jeffrey A Wickersham
INTRODUCTION: Cisgender and transgender woman sex workers (CWSWs and TWSWs, respectively) are key populations in Malaysia with higher HIV-prevalence than that of the general population. Given the impact economic instability can have on HIV transmission in these populations, novel HIV prevention interventions that reduce poverty may reduce HIV incidence and improve linkage and retention to care for those already living with HIV. We examine the feasibility of a microfinance-based HIV prevention intervention among CWSW and TWSWs in Greater Kuala Lumpur, Malaysia...
August 2, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28782332/virological-outcomes-of-antiretroviral-therapy-in-zomba-central-prison-malawi-a-cross-sectional-study
#7
REVIEW
Happy Mpawa, Aunex Kwekwesa, Alemayehu Amberbir, Daniela Garone, Oscar H Divala, Gift Kawalazira, Vanessa van Schoor, Henry Ndindi, Joep J van Oosterhout
INTRODUCTION: Antiretroviral therapy (ART) outcomes that include viral suppression rates are rarely reported among African prison populations. Prisoners deal with specific challenges concerning adherence to ART. We aimed to describe virological outcomes of ART in a large prison in Malawi. METHODS: A cross-sectional study of ART outcomes was conducted at the Zomba Central Prison HIV clinic, Malawi, following the introduction of routine viral load monitoring. All prisoners on ART for at least 6 months were eligible for a viral load test...
July 31, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28782335/elimination-of-hcv-as-a-public-health-concern-among-people-who-inject-drugs-by-2030-what-will-it-take-to-get-there
#8
REVIEW
Jason Grebely, Gregory J Dore, Sébastien Morin, Jürgen K Rockstroh, Marina B Klein
INTRODUCTION: Globally, there is a considerable burden of HCV and HIV infections among people who inject drugs (PWID) and transmission of both infections continues. Needle and syringe programme (NSP) and opioid substitution therapy (OST) coverage remains low, despite evidence demonstrating their prevention benefit. Direct-acting antiviral therapies (DAA) with HCV cure >95% among PWID provide an opportunity to reverse rising trends in HCV-related morbidity and mortality and reduce incidence...
July 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28741330/world-hepatitis-day-fighting-hepatitis-c-in-latin-america-and-the-caribbean-an-urgent-call
#9
REVIEW
Luis Enrique Soto-Ramirez
No abstract text is available yet for this article.
July 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28741333/hiv-affected-couples-and-individuals-who-desire-children-should-be-offered-options-for-safer-conception
#10
LETTER
Lealah C Pollock, Shannon Weber, Angela Kaida, Lynn T Matthews, Dominika L Seidman
No abstract text is available yet for this article.
July 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28741332/willingness-to-use-hiv-pre-exposure-prophylaxis-among-gay-men-other-men-who-have-sex-with-men-and-transgender-women-in-myanmar
#11
Bridget L Draper, Zaw Min Oo, Zaw Win Thein, Poe Poe Aung, Vanessa Veronese, Claire Ryan, Myo Thant, Chad Hughes, Mark Stoové
INTRODUCTION: HIV pre-exposure prophylaxis (PrEP) has emerged as a key component of contemporary HIV combination prevention strategies. To explore the local suitability of PrEP, country-specific acceptability studies are needed to inform potential PrEP implementation. In the context of Myanmar, in addition to resource constraints, HIV service access by gay men, other men who have sex with men, and transgender women (GMT) continues to be constrained by legislative and community stigma and marginalization...
July 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28741331/alignment-of-adherence-and-risk-for-hiv-acquisition-in-a-demonstration-project-of-pre-exposure-prophylaxis-among-hiv-serodiscordant-couples-in-kenya-and-uganda-a-prospective-analysis-of-prevention-effective-adherence
#12
Jessica E Haberer, Lara Kidoguchi, Renee Heffron, Nelly Mugo, Elizabeth Bukusi, Elly Katabira, Stephen Asiimwe, Katherine K Thomas, Connie Celum, Jared M Baeten
INTRODUCTION: Adherence is essential for pre-exposure prophylaxis (PrEP) to protect against HIV acquisition, but PrEP use need not be life-long. PrEP is most efficient when its use is aligned with periods of risk - a concept termed prevention-effective adherence. The objective of this paper is to describe prevention-effective adherence and predictors of adherence within an open-label delivery project of integrated PrEP and antiretroviral therapy (ART) among HIV serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project)...
July 25, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770599/effect-of-frequency-of-clinic-visits-and-medication-pick-up-on-antiretroviral-treatment-outcomes-a-systematic-literature-review-and-meta-analysis
#13
Tsitsi Mutasa-Apollo, Nathan Ford, Matthew Wiens, Maria Eugenia Socias, Eyerusalem Negussie, Ping Wu, Evan Popoff, Jay Park, Edward J Mills, Steve Kanters
INTRODUCTION: Expanding and sustaining antiretroviral therapy (ART) coverage may require simplified HIV service delivery strategies that concomitantly reduce the burden of care on the health system and patients while ensuring optimal outcomes. We conducted a systematic review to assess the impact of reduced frequency of clinic visits and drug dispensing on patient outcomes. METHODS: As part of the development process of the World Health Organization antiretroviral (ARV) guidelines, we systematically searched medical literature databases for publications up to 30 August 2016...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770598/expanding-hiv-testing-and-linkage-to-care-in-southwestern-uganda-with-community-health-extension-workers
#14
REVIEW
Stephen Asiimwe, Jennifer M Ross, Anthony Arinaitwe, Obed Tumusiime, Bosco Turyamureeba, D Allen Roberts, Gabrielle O'Malley, Ruanne V Barnabas
INTRODUCTION: Achieving the UNAIDS goals of 90-90-90 will require more than doubling the number of people accessing HIV care in Uganda. Community-based programmes for entry into HIV care are effective strategies to expand access to HIV care, but few programmes have been evaluated with a particular focus on scale-up. METHODS: Integrated Community Based Initiatives, a Uganda-based non-governmental organization, designed and implemented a programme of community-based HIV counselling and testing and facilitated linkage to care utilizing community health extension workers (CHEWs) in rural Sheema District, Uganda...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770597/can-differentiated-care-models-solve-the-crisis-in-hiv-treatment-financing-analysis-of-prospects-for-38-countries-in-sub-saharan-africa
#15
Catherine Barker, Arin Dutta, Kate Klein
INTRODUCTION: Rapid scale-up of antiretroviral therapy (ART) in the context of financial and health system constraints has resulted in calls to maximize efficiency in ART service delivery. Adopting differentiated care models (DCMs) for ART could potentially be more cost-efficient and improve outcomes. However, no study comprehensively projects the cost savings across countries. We model the potential reduction in facility-level costs and number of health workers needed when implementing two types of DCMs while attempting to reach 90-90-90 targets in 38 sub-Saharan African countries from 2016 to 2020...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770596/high-rates-of-viral-suppression-in-adults-and-children-with-high-cd4-counts-using-a-streamlined-art-delivery-model-in-the-search-trial-in-rural-uganda-and-kenya
#16
Dalsone Kwarisiima, Moses R Kamya, Asiphas Owaraganise, Florence Mwangwa, Dathan M Byonanebye, James Ayieko, Albert Plenty, Doug Black, Tamara D Clark, Bridget Nzarubara, Katherine Snyman, Lillian Brown, Elizabeth Bukusi, Craig R Cohen, Elvin H Geng, Edwin D Charlebois, Theodore D Ruel, Maya L Petersen, Diane Havlir, Vivek Jain
INTRODUCTION: The 2015 WHO recommendation of antiretroviral therapy (ART) for all HIV-positive persons calls for treatment initiation in millions of persons newly eligible with high CD4+ counts. Efficient and effective care models are urgently needed for this population. We evaluated clinical outcomes of asymptomatic HIV-positive adults and children starting ART with high CD4+ counts using a novel streamlined care model in rural Uganda and Kenya. METHODS: In the 16 intervention communities of the HIV test-and-treat Sustainable East Africa Research for Community Health Study (NCT01864603), all HIV-positive individuals irrespective of CD4 were offered ART (efavirenz [EFV]/tenofovir disoproxil fumarate + emtricitabine (FTC) or lamivudine (3TC)...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770595/high-rates-of-retention-and-viral-suppression-in-the-scale-up-of-antiretroviral-therapy-adherence-clubs-in-cape-town-south-africa
#17
Priscilla Ruvimbo Tsondai, Lynne Susan Wilkinson, Anna Grimsrud, Precious Thembekile Mdlalo, Angelica Ullauri, Andrew Boulle
INTRODUCTION: Increasingly, there is a need for health authority scale up of successfully piloted differentiated models of antiretroviral therapy (ART) delivery. However, there is a paucity of evidence on system-wide outcomes after scale-up. In the Cape Town health district, stable adult patients were referred to adherence clubs (ACs) - a group model of ART delivery with five visits per year. By the end of March 2015, over 32,000 ART patients were in an AC. We describe patient outcomes of a representative sample of AC patients during this scale-up...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770594/multi-month-prescriptions-fast-track-refills-and-community-art-groups-results-from-a-process-evaluation-in-malawi-on-using-differentiated-models-of-care-to-achieve-national-hiv-treatment-goals
#18
REVIEW
Margaret L Prust, Clement K Banda, Rose Nyirenda, Frank Chimbwandira, Thokozani Kalua, Andreas Jahn, Michael Eliya, Katie Callahan, Peter Ehrenkranz, Marta R Prescott, Elizabeth A McCarthy, Elya Tagar, Andrews Gunda
INTRODUCTION: In order to facilitate scale-up of antiretroviral therapy (ART) in Malawi, innovative and pragmatic models have been developed to optimize the efficiency of HIV service delivery. In particular, three models of differentiated care have emerged for stable patients: adjusted appointment spacing through multi-month scripting (MMS); fast-track drug refills (FTRs) on alternating visits; and community ART groups (CAGs) where group members rotate in collecting medications at the facility for all members...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770593/differentiated-models-of-care-for-postpartum-women-on-antiretroviral-therapy-in-cape-town-south-africa-a-cohort-study
#19
REVIEW
Landon Myer, Victoria Iyun, Allison Zerbe, Tamsin K Phillips, Kirsty Brittain, Elton Mukonda, Joanna Allerton, Cathy D Kalombo, Andile Nofemela, Elaine J Abrams
BACKGROUND: The numbers of women initiating lifelong antiretroviral therapy (ART) during pregnancy and postpartum is increasing rapidly, presenting a burden on health systems and an urgent need for scalable models of care for this population. In a pilot project, we referred postpartum women who initiated ART during pregnancy to a community-based model of differentiated ART services. METHODS: Eligible women (on ART for at least 3 months with viral load (VL)<1000 copies/mL) were offered a choice of two ART models of care: (i) referral to an existing system of community-based 'adherence clubs', operated by lay counsellors with medication collection every 2-4 months; or (ii) referral to local primary healthcare clinics (PHC) with services provided by clinicians and medication collection every 1-2 months (local standard of care for postpartum ART)...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770592/a-call-for-differentiated-approaches-to-delivering-hiv-services-to-key-populations
#20
REVIEW
Virginia Macdonald, Annette Verster, Rachel Baggaley
INTRODUCTION: Key populations (KPs) are disproportionally affected by HIV and have low rates of access to HIV testing and treatment services compared to the broader population. WHO promotes the use of differentiated approaches for reaching and recruiting KP into the HIV services continuum. These approaches may help increase access to KPs who are often criminalized or stigmatized. By catering to the specific needs of each KP individual, differentiated approaches may increase service acceptability, quality and coverage, reduce costs and support KP members in leading the HIV response among their communities...
July 21, 2017: Journal of the International AIDS Society
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