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Journal of the International AIDS Society

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https://www.readbyqxmd.com/read/29998619/pre-exposure-prophylaxis-for-men-who-have-sex-with-men-in-china-challenges-for-routine-implementation
#1
Chongyi Wei, H Fisher Raymond
No abstract text is available yet for this article.
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29989338/hiv-and-sexually-transmitted-infections-responding-to-the-newest-normal
#2
Kenneth H Mayer, Henry de Vries
No abstract text is available yet for this article.
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29987877/systemic-dpp4-activity-is-reduced-during-primary-hiv-1-infection-and-is-associated-with-intestinal-rorc-cd4-cell-levels-a-surrogate-marker-candidate-of-hiv-induced-intestinal-damage
#3
Mickaël J Ploquin, Armanda Casrouge, Yoann Madec, Nicolas Noël, Beatrice Jacquelin, Nicolas Huot, Darragh Duffy, Simon P Jochems, Luca Micci, Camille Lécuroux, Faroudy Boufassa, Thijs Booiman, Thalia Garcia-Tellez, Mathilde Ghislain, Roger Le Grand, Olivier Lambotte, Neeltje Kootstra, Laurence Meyer, Cecile Goujard, Mirko Paiardini, Matthew L Albert, Michaela Müller-Trutwin
INTRODUCTION: Combined anti-retroviral therapy (cART) transformed HIV-1 from a deadly disease into a chronic infection, but does not cure HIV infection. It also does not fully restore HIV-induced gut damage unless administered extremely early after infection. Additional biomarkers are needed to evaluate the capacity of therapies aimed at HIV remission/cure to restore HIV-induced intestinal immune damage and limit chronic inflammation. Herein, we aimed to identify a systemic surrogate marker whose levels would reflect gut immune damage such as intestinal Th17 cell loss starting from primary HIV-1 infection...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29984473/a-prospective-test-and-treat-demonstration-project-among-people-who-inject-drugs-in-vietnam
#4
Hai H Nguyen, Duong D Bui, Thuy Tt Dinh, Loc Q Pham, Van Tt Nguyen, Tram H Tran, Thang H Pham, Sang M Nguyen, Amitabh B Suthar, Nhan T Do, Nathan Ford, Ying-Ru Lo, Long Hoang Nguyen, Le M Giang, Masaya Kato
INTRODUCTION: Modelling suggests that early diagnosis and immediate antiretroviral therapy (ART) among key populations would have a substantial impact in reducing HIV transmission and mortality in Vietnam. An implementation research project of "test-and-treat" among people who inject drugs (PWID) was developed to inform effective roll-out of such interventions. METHODS: "Test-and-treat" was offered to PWID in two high burden provinces, Thai Nguyen and Thanh Hoa...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29972632/models-of-support-for-disclosure-of-hiv-status-to-hiv-infected-children-and-adolescents-in-resource-limited-settings
#5
Elise Arrivé, Samuel Ayaya, Mary-Ann Davies, Cleophas Chimbetete, Andrew Edmonds, Patricia Lelo, Siew Moy Fong, Kamarul Azahar Razali, Kouadio Kouakou, Stephany N Duda, Valériane Leroy, Rachel C Vreeman
INTRODUCTION: Disclosure of HIV status to HIV-infected children and adolescents is a major care challenge. We describe current site characteristics related to disclosure of HIV status in resource-limited paediatric HIV care settings within the International Epidemiology Databases to Evaluate AIDS (IeDEA) consortium. METHODS: An online site assessment survey was conducted across the paediatric HIV care sites within six global regions of IeDEA. A standardized questionnaire was administered to the sites through the REDCap platform...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29972628/maternal-priorities-for-preventive-therapy-among-hiv-positive-pregnant-women-before-and-after-delivery-in-south-africa-a-best-worst-scaling-survey
#6
Hae-Young Kim, David W Dowdy, Neil A Martinson, Jonathan E Golub, John F P Bridges, Colleen F Hanrahan
INTRODUCTION: Pregnant women newly diagnosed with HIV during pregnancy are often lost to follow up and their adherence rates drop after delivery. We quantified changes in priorities related to isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) among pregnant women living with HIV. METHODS: We enrolled pregnant women recently diagnosed with HIV from 14 primary health clinics during pregnancy and followed them after delivery in Matlosana, South Africa...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29972287/community-mobilization-to-modify-harmful-gender-norms-and-reduce-hiv-risk-results-from-a-community-cluster-randomized-trial-in-south-africa
#7
Audrey Pettifor, Sheri A Lippman, Ann Gottert, Chirayath M Suchindran, Amanda Selin, Dean Peacock, Suzanne Maman, Dumisani Rebombo, Rhian Twine, Francesc Xavier Gómez-Olivé, Stephen Tollman, Kathleen Kahn, Catherine MacPhail
INTRODUCTION: Community mobilization (CM) is increasingly recognized as critical to generating changes in social norms and behaviours needed to achieve reductions in HIV. We conducted a CM intervention to modify negative gender norms, particularly among men, in order to reduce associated HIV risk. METHODS: Twenty two villages in the Agincourt Health and Socio-Demographic Surveillance Site in rural Mpumalanga, South Africa were randomized to either a theory-based, gender transformative, CM intervention or no intervention...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29956882/sex-based-differences-in-antiretroviral-therapy-initiation-switching-and-treatment-interruptions-global-overview-from-the-international-epidemiologic-databases-to-evaluate-aids-iedea
#8
Michelle L Giles, Amit C Achhra, Alison G Abraham, Andreas D Haas, Michael John Gill, Man Po Lee, Marco Luque, Catherine McGowan, Morna Cornell, Paula Braitstein, Nathalie de Rekeneire, Renaud Becquet, Kara Wools-Kaloustian, Matthew Law
INTRODUCTION: In 2015, the World Health Organization recommended that all HIV-infected individuals consider ART initiation as soon as possible after diagnosis. Sex differences in choice of initial ART regimen, indications for switching, time to switching and choice of second-line regimens have not been well described. The aims of this study were to describe first-line ART and CD4 count at ART initiation by sex, calendar year and region, and to analyse time to change or interruption in first-line ART, according to sex in each region...
June 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29956496/in-memoriam-professor-david-cooper-1949-to-2018
#9
EDITORIAL
Susan Kippax, Kenneth H Mayer, Annette Sohn, Linda-Gail Bekker, Anton Pozniak, Chris Beyrer, Sharon R Lewin, Owen Ryan, Praphan Phanuphak, Michael Kirby
No abstract text is available yet for this article.
June 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29956491/addressing-the-unique-needs-of-adolescent-mothers-in-the-fight-against-hiv
#10
Allison K Groves, Suzanne Maman, Petra H Stankard, Luwam T Gebrekristos, Joseph J Amon, Dhayendre Moodley
No abstract text is available yet for this article.
June 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29939488/prevention-paradox-medical-students-are-less-inclined-to-prescribe-hiv-pre-exposure-prophylaxis-for-patients-in-highest-need
#11
Sarah K Calabrese, Valerie A Earnshaw, Kristen Underhill, Douglas S Krakower, Manya Magnus, Nathan B Hansen, Kenneth H Mayer, Joseph R Betancourt, Trace S Kershaw, John F Dovidio
INTRODUCTION: Despite healthcare providers' growing awareness of pre-exposure prophylaxis (PrEP), prescription rates remain low. PrEP is an efficacious HIV prevention strategy recommended for use with condoms but still protective in their absence. Concern about the impact of PrEP on condom use and other risk behaviour is, nonetheless, among the barriers to prescription commonly reported. To understand the implications of this concern for PrEP access, we examined how medical students' willingness to prescribe PrEP varied by patients' condom use and partnering practices...
June 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29939483/same-day-antiretroviral-therapy-art-initiation-in-pregnancy-is-not-associated-with-viral-suppression-or-engagement-in-care-a-cohort-study
#12
Nontokozo Langwenya, Tamsin K Phillips, Kirsty Brittain, Allison Zerbe, Elaine J Abrams, Landon Myer
INTRODUCTION: Many prevention of mother-to-child HIV transmission programmes across Africa initiate HIV-infected (HIV positive) pregnant women on lifelong antiretroviral therapy (ART) on the first day of antenatal care ("same-day" initiation). However, there are concerns that same-day initiation may limit patient preparation before starting ART and contribute to subsequent non-adherence, disengagement from care and raised viral load. We examined if same-day initiation was associated with viral suppression and engagement in care during pregnancy...
June 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29890048/universal-test-and-treat-is-not-associated-with-sub-optimal-antiretroviral-therapy-adherence-in-rural-south-africa-the-anrs-12249-tasp-trial
#13
Collins Iwuji, Nuala McGrath, Alexandra Calmy, Francois Dabis, Deenan Pillay, Marie-Louise Newell, Kathy Baisley, Kholoud Porter
INTRODUCTION: HIV treatment guidelines now recommend antiretroviral therapy (ART) initiation regardless of CD4 count to maximize benefit both for the individual and society. It is unknown whether the initiation of ART at higher CD4 counts would affect adherence levels. We investigated whether initiating ART at higher CD4 counts was associated with sub-optimal adherence (<95%) during the first 12 months of ART. METHODS: A prospective cohort study nested within a two-arm cluster-randomized trial of universal test and treat was implemented from March 2012 to June 2016 to measure the impact of ART on HIV incidence in rural KwaZulu-Natal...
June 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29883052/optimal-timing-of-hiv-home-based-counselling-and-testing-rounds-in-western-kenya
#14
Jack J Olney, Jeffrey W Eaton, Paula Braitstein, Joseph W Hogan, Timothy B Hallett
INTRODUCTION: Weaknesses in care programmes providing anti-retroviral therapy (ART) persist and are often instigated by late HIV diagnosis and poor linkage to care. We investigated the potential for a home-based counselling and testing (HBCT) campaign to be improved through the optimal timing and enhancement of testing rounds to generate greater health outcomes at minimum cost. METHODS: Using a mathematical model of HIV care calibrated to longitudinal data from The Academic Model Providing Access To Healthcare (AMPATH) in Kenya, we simulated HBCT campaigns between 2016 and 2036, assessing the impact and total cost of care for each, for a further 20 years...
June 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29878719/including-the-criminal-justice-involved-at-the-hiv-policy-research-and-service-delivery-table
#15
Derrick T Ndlovu, Christopher J Hoffmann
No abstract text is available yet for this article.
June 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29873885/evidence-of-synergistic-relationships-between-hiv-and-human-papillomavirus-hpv-systematic-reviews-and-meta-analyses-of-longitudinal-studies-of-hpv-acquisition-and-clearance-by-hiv-status-and-of-hiv-acquisition-by-hpv-status
#16
REVIEW
Katharine J Looker, Minttu M Rönn, Patrick M Brock, Marc Brisson, Melanie Drolet, Philippe Mayaud, Marie-Claude Boily
INTRODUCTION: Observational studies suggest HIV and human papillomavirus (HPV) infections may have multiple interactions. We reviewed the strength of the evidence for the influence of HIV on HPV acquisition and clearance, and the influence of HPV on HIV acquisition. METHODS: We performed meta-analytic systematic reviews of longitudinal studies of HPV incidence and clearance rate by HIV status (review 1) and of HIV incidence by HPV status (review 2). We pooled relative risk (RR) estimates across studies using random-effect models...
June 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29870128/investments-in-implementation-science-are-needed-to-address-the-harms-associated-with-the-sexualized-use-of-substances-among-gay-bisexual-and-other-men-who-have-sex-with-men
#17
https://www.readbyqxmd.com/read/29852062/targeted-hiv-testing-at-birth-supported-by-low-and-predictable-mother-to-child-transmission-risk-in-botswana
#18
Maryanne Ibrahim, Kenneth Maswabi, Gbolahan Ajibola, Sikhulile Moyo, Michael D Hughes, Oganne Batlang, Maureen Sakoi, Chloe Auletta-Young, Laura Vaughan, Shahin Lockman, Patrick Jean-Philippe, Xu Yu, Matthias Lichterfeld, Daniel R Kuritzkes, Joseph Makhema, Roger L Shapiro
INTRODUCTION: Most African countries perform infant HIV testing at 6 weeks or later. The addition of targeted testing at birth may improve retention in care, treatment outcomes and survival for HIV-infected infants. METHODS: HIV-exposed infants were screened as part of the Early Infant Treatment (EIT) study in Botswana. Screened infants were ≥35 weeks gestational age and ≥2000 g at birth. Risk factors for mother-to-child transmission (MTCT) were assessed by maternal obstetric card or verbally...
May 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29851436/integrated-delivery-of-antiretroviral-treatment-and-pre-exposure-prophylaxis-to-hiv-1-serodiscordant-couples-in-east-africa-a-qualitative-evaluation-study-in-uganda
#19
Norma C Ware, Emily E Pisarski, Edith Nakku-Joloba, Monique A Wyatt, Timothy R Muwonge, Bosco Turyameeba, Stephen B Asiimwe, Renee A Heffron, Jared M Baeten, Connie L Celum, Elly T Katabira
INTRODUCTION: Serodiscordant couples are a priority population for delivery of new HIV prevention interventions in Africa. An integrated strategy of delivering time-limited, oral pre-exposure prophylaxis (PrEP) to uninfected partners in serodiscordant couples as a bridge to long-term antiretroviral treatment (ART) for infected partners has been implemented in East Africa, nearly eliminating new infections. We conducted a qualitative evaluation of the integrated strategy in Uganda, to better understand its success...
May 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29722482/five-year-neurodevelopment-outcomes-of-perinatally-hiv-infected-children-on-early-limited-or-deferred-continuous-antiretroviral-therapy
#20
Barbara Laughton, Morna Cornell, Martin Kidd, Priscilla Estelle Springer, Els Françoise Marie-Thérèse Dobbels, Anita Janse Van Rensburg, Kennedy Otwombe, Abdel Babiker, Diana M Gibb, Avy Violari, Mariana Kruger, Mark Fredric Cotton
INTRODUCTION: Early antiretroviral therapy (ART) has improved neurodevelopmental outcomes of HIV-infected (HIV-positive) children; however, little is known about the longer term outcomes in infants commencing early ART or whether temporary ART interruption might have long-term consequences. In the children with HIV early antiretroviral treatment (CHER) trial, HIV-infected infants ≤12 weeks of age with CD4 ≥25% were randomized to deferred ART (ART-Def); immediate time-limited ART for 40 weeks (ART-40W) or 96 weeks (ART-96W)...
May 2018: Journal of the International AIDS Society
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