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Journal of the International AIDS Society

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https://www.readbyqxmd.com/read/28884524/hiv-transmission-and-retention-in-care-among-hiv-exposed-children-enrolled-in-malawi-s-prevention-of-mother-to-child-transmission-programme
#1
Andreas D Haas, Joep J van Oosterhout, Lyson Tenthani, Andreas Jahn, Marcel Zwahlen, Malango T Msukwa, Mary-Ann Davies, Kali Tal, Nozgechi Phiri, Adrian Spoerri, Frank Chimbwandira, Matthias Egger, Olivia Keiser
INTRODUCTION: In Malawi, HIV-infected pregnant and breastfeeding women are offered lifelong antiretroviral therapy (ART) regardless of CD4 count or clinical stage (Option B+). Their HIV-exposed children are enrolled in the national prevention of mother-to-child transmission (PMTCT) programme, but many are lost to follow-up. We estimated the cumulative incidence of vertical HIV transmission, taking loss to follow-up into account. METHODS: We abstracted data from HIV-exposed children enrolled into care between September 2011 and June 2014 from patient records at 21 health facilities in central and southern Malawi...
September 4, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872281/transitioning-young-adults-from-paediatric-to-adult-care-and-the-hiv-care-continuum-in-atlanta-georgia-usa-a-retrospective-cohort-study
#2
Sophia A Hussen, Rana Chakraborty, Andrea Knezevic, Andres Camacho-Gonzalez, Eugene Huang, Rob Stephenson, Carlos Del Rio
INTRODUCTION: The transition from paediatric to adult HIV care is a particularly high-risk time for disengagement among young adults; however, empirical data are lacking. METHODS: We reviewed medical records of 72 youth seen in both the paediatric and the adult clinics of the Grady Infectious Disease Program in Atlanta, Georgia, USA, from 2004 to 2014. We abstracted clinical data on linkage, retention and virologic suppression from the last two years in the paediatric clinic through the first two years in the adult clinic...
September 1, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872269/clinical-outcomes-in-children-and-adolescents-initiating-antiretroviral-therapy-in-decentralized-healthcare-settings-in-zimbabwe
#3
Grace McHugh, Victoria Simms, Ethel Dauya, Tsitsi Bandason, Prosper Chonzi, Dafni Metaxa, Shungu Munyati, Kusum Nathoo, Hilda Mujuru, Katharina Kranzer, Rashida A Ferrand
INTRODUCTION: Decentralized HIV care for adults does not appear to compromise clinical outcomes. HIV care for children poses additional clinical and social complexities. We conducted a prospective cohort study to investigate clinical outcomes in children aged 6-15 years who registered for HIV care at seven primary healthcare clinics (PHCs) in Harare, Zimbabwe. METHODS: Participants were recruited between January 2013 and December 2014 and followed for 18 months...
September 1, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28853518/early-virological-response-to-hiv-treatment-can-we-predict-who-is-likely-to-experience-subsequent-treatment-failure-results-from-an-observational-cohort-study-london-uk
#4
Nataliya Brima, Fiona C Lampe, Andrew Copas, Richard Gilson, Ian Williams, Margaret A Johnson, Andrew N Phillips, Colette J Smith
INTRODUCTION: For people living with HIV, the first antiretroviral treatment (ART) regimen offers the best chance for a good virological response. Early identification of those unlikely to respond to first-line ART could enable timely intervention and increase chances of a good initial treatment response. In this study we assess the extent to which the HIV RNA viral load (VL) at 1 and 3 months is predictive of first-line treatment outcome at 6 months. Methods All previously ART-naive individuals starting ART at two London centres since 2000 with baseline (-180 to 3 days) VL >500 c/mL had a VL measurement between 6 and 12 months after starting ART, and at least one at month 1 (4-60 days) or month 3 (61-120 days) were included...
August 30, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872279/hiv-point-of-care-diagnosis-preventing-misdiagnosis-experience-from-a-pilot-of-rapid-test-algorithm-implementation-in-selected-communes-in-vietnam
#5
REVIEW
Van Thi Thuy Nguyen, Susan Best, Hong Thang Pham, Thi Xuan Lien Troung, Thi Thanh Ha Hoang, Kim Wilson, Thi Hong Hanh Ngo, Xuan Chien, Kim Anh Lai, Duc Duong Bui, Masaya Kato
INTRODUCTION: In Vietnam, HIV testing services had been available only at provincial and district health facilities, but not at the primary health facilities. Consequently, access to HIV testing services had been limited especially in rural areas. In 2012, Vietnam piloted decentralization and integration of HIV services at commune health stations (CHSs). As a part of this pilot, a three-rapid test algorithm was introduced at CHSs. The objective of this study was to assess the performance of a three-rapid test algorithm and the implementation of quality assurance measures to prevent misdiagnosis, at primary health facilities...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872278/hiv-misdiagnosis-in-paediatrics-unpacking-the-complexity
#6
REVIEW
Emma Sacks, Jennifer Cohn, Martina Penazzato
No abstract text is available yet for this article.
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872277/misdiagnosed-hiv-infection-in-pregnant-women-initiating-universal-art-in-south-africa
#7
Nei-Yuan Hsiao, Allison Zerbe, Tamsin K Phillips, Landon Myer, Elaine J Abrams
INTRODUCTION: Rapid diagnostic tests (RDTs) are the primary diagnostic tools for HIV used in resource-constrained settings. Without a proper confirmation algorithm, there is concern that false-positive (FP) RDTs could result in misdiagnosis of HIV infection and inappropriate antiretroviral treatment (ART) initiation, but programmatic data on FP are few. METHODS: We examined the accuracy of RDT diagnosis among HIV-infected pregnant women attending public sector antenatal services in Cape Town, South Africa...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872276/prevalence-and-outcomes-of-hiv-1-diagnostic-challenges-during-universal-birth-testing-an-urban-south-african-observational-cohort
#8
Karl-Günter Technau, Ahmad Haeri Mazanderani, Louise Kuhn, Lucia Hans, Renate Strehlau, Elaine J Abrams, Martie Conradie, Ashraf Coovadia, Ndileka Mbete, Pamela M Murnane, Faeezah Patel, Stephanie Shiau, Caroline T Tiemessen, Gayle G Sherman
INTRODUCTION: HIV-1 polymerase chain reaction (PCR) testing at birth aims to facilitate earlier initiation of antiretroviral therapy (ART) for HIV-infected neonates. Data from two years of universal birth testing implementation in a high-burden South African urban setting are presented to demonstrate the prevalence and outcomes of diagnostic challenges in this context. METHODS: HIV-exposed neonates born at Rahima Moosa Mother and Child Hospital between 5 June 2014 and 31 August 2016 were routinely screened at birth for HIV-1 on whole blood samples using the COBAS® AmpliPrep/COBAS® TaqMan (CAP/CTM) HIV-1 Qualitative Test, version 2...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872275/false-negative-hiv-tests-using-oral-fluid-tests-in-children-taking-antiretroviral-therapy-from-harare-zimbabwe
#9
Ioana D Olaru, Grace McHugh, Suba Dakshina, Edith Majonga, Ethel Dauya, Tsitsi Bandason, Katharina Kranzer, Hilda Mujuru, Rashida A Ferrand
INTRODUCTION: Rapid diagnostic tests (RDT) for HIV infection have high sensitivity and specificity, but in the setting of longstanding antiretroviral therapy (ART), can give false results that can lead to misinterpretation, confusion and inadequate management. The objective of this study was to evaluate the proportion of falsely negative results of a RDT performed on oral fluid in HIV-infected children on longstanding ART. METHODS: One hundred and twenty-nine children with known HIV infection and receiving ART were recruited from the HIV Clinic at the Harare Central Hospital, Zimbabwe...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872274/misdiagnosis-of-hiv-infection-during-a-south-african-community-based-survey-implications-for-rapid-hiv-testing
#10
REVIEW
Tendesayi Kufa, Ayesha Bm Kharsany, Cherie Cawood, David Khanyile, Lara Lewis, Anneke Grobler, Zawadi Chipeta, Alfred Bere, Mary Glenshaw, Adrian Puren
INTRODUCTION: We describe the overall accuracy and performance of a serial rapid HIV testing algorithm used in community-based HIV testing in the context of a population-based household survey conducted in two sub-districts of uMgungundlovu district, KwaZulu-Natal, South Africa, against reference fourth-generation HIV-1/2 antibody and p24 antigen combination immunoassays. We discuss implications of the findings on rapid HIV testing programmes. METHODS: Cross-sectional design: Following enrolment into the survey, questionnaires were administered to eligible and consenting participants in order to obtain demographic and HIV-related data...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872273/identification-of-misdiagnosed-hiv-clients-in-an-early-access-to-art-for-all-implementation-study-in-swaziland
#11
Shaukat Khan, Emma Mafara, Munyaradzi Pasipamire, Donna Spiegelman, Sikhathele Mazibuko, Nombuso Ntshalintshali, Anita Hettema, Charlotte Lejeune, Fiona Walsh, Velephi Okello
INTRODUCTION: Rapid diagnostic testing has made HIV diagnosis and subsequent treatment more accessible. However, multiple factors, including improper implementation of testing strategies and clerical errors, have been reported to lead to HIV misdiagnosis. The World Health Organization has recommended HIV retesting prior to antiretroviral therapy (ART) initiation which has become pertinent with scaling up of Early Access to ART for All (EAAA). In this analysis, misdiagnosed clients are identified from a subgroup of clients enrolled in EAAA implementation study in Swaziland...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872272/understanding-low-sensitivity-of-community-based-hiv-rapid-testing-experiences-from-the-hptn-071-popart-trial-in-zambia-and-south-africa
#12
Peter Bock, Comfort Phiri, Estelle Piwowar-Manning, Barry Kosloff, Nomtha Mandla, Alicia Young, Anelet James, Ab Schaap, Michelle Scheepers, Deborah Donnell, Sam Griffith, Wafaa El-Sadr, Kwame Shanaube, Nulda Beyers, Richard Hayes, Sarah Fidler, Helen Ayles
INTRODUCTION: Population-wide HIV testing services (HTS) must be delivered in order to achieve universal antiretroviral treatment (ART) coverage. To accurately deliver HTS at such scale, non-facility-based HIV point-of-care testing (HIV-POCT) is necessary but requires rigorous quality assurance (QA). This study assessed the performance of community-wide HTS in Zambia and South Africa (SA) as part of the HPTN 071 (PopART) study and explores the impact of quality improvement interventions on HTS performance...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872271/to-err-is-human-to-correct-is-public-health-a-systematic-review-examining-poor-quality-testing-and-misdiagnosis-of-hiv-status
#13
Cheryl C Johnson, Virginia Fonner, Anita Sands, Nathan Ford, Carla Mahklouf Obermeyer, Sharon Tsui, Vincent Wong, Rachel Baggaley
INTRODUCTION: In accordance with global testing and treatment targets, many countries are seeking ways to reach the "90-90-90" goals, starting with diagnosing 90% of all people with HIV. Quality HIV testing services are needed to enable people with HIV to be diagnosed and linked to treatment as early as possible. It is essential that opportunities to reach people with undiagnosed HIV are not missed, diagnoses are correct and HIV-negative individuals are not inadvertently initiated on life-long treatment...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28872270/a-public-health-approach-to-addressing-and-preventing-misdiagnosis-in-the-scale-up-of-hiv-rapid-testing-programmes
#14
EDITORIAL
Cheryl C Johnson, Shona Dalal, Rachel Baggaley, Miriam Taegtmeyer
No abstract text is available yet for this article.
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28853517/hiv-violence-blame-and-shame-pathways-of-risk-to-internalized-hiv-stigma-among-south-african-adolescents-living-with-hiv
#15
Marija Pantelic, Mark Boyes, Lucie Cluver, Franziska Meinck
INTRODUCTION: Internalized HIV stigma is a key risk factor for negative outcomes amongst adolescents living with HIV (ALHIV), including non-adherence to anti-retroviral treatment, loss-to-follow-up and morbidity. This study tested a theoretical model of multi-level risk pathways to internalized HIV stigma among South African ALHIV. METHODS: From 2013 to 2015, a survey using total population sampling of ALHIV who had ever initiated anti-retroviral treatment (ART) in 53 public health facilities in the Eastern Cape, South Africa was conducted...
August 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28812339/young-people-hiv-and-life-goals
#16
REVIEW
Kathleen M MacQueen
No abstract text is available yet for this article.
August 14, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28799325/comparison-between-next-generation-and-sanger-based-sequencing-for-the-detection-of-transmitted-drug-resistance-mutations-among-recently-infected-hiv-1-patients-in-israel-2000-2014
#17
Roy Moscona, Daniela Ram, Marina Wax, Efrat Bucris, Itzchak Levy, Ella Mendelson, Orna Mor
INTRODUCTION: Transmitted drug-resistance mutations (TDRM) may hamper successful anti-HIV-1 therapy and impact future control of the HIV-1 epidemic. Recently infected, therapy-naïve individuals are best suited for surveillance of such TDRM. In this study, TDRM, detected by next-generation sequencing (NGS) were compared to those identified by Sanger-based population sequencing (SBS) in recently infected HIV-1 patients. METHODS: Historical samples from 80 recently infected HIV-1 patients, diagnosed between 2000 and 2014, were analysed by MiSeq (NGS) and ABI (SBS)...
August 11, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28799324/reviewing-independent-access-to-hiv-testing-counselling-and-treatment-for-adolescents-in-hiv-specific-laws-in-sub-saharan-africa-implications-for-the-hiv-response
#18
Patrick M Eba, HyeYoung Lim
INTRODUCTION: AIDS is a leading cause of death among adolescents in sub-Saharan Africa. Yet, legal, policy and social barriers continue to restrict their access to HIV services. In recent years, access to independent HIV testing and treatment for adolescents has gained increased attention. The 2013 WHO Guidance on HIV testing and counselling and care for adolescents living with HIV (WHO Guidance) calls for reviewing legal and regulatory frameworks to facilitate adolescents' access to comprehensive HIV services...
August 11, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28782334/pregnant-adolescents-living-with-hiv-what-we-know-what-we-need-to-know-where-we-need-to-go
#19
Tegan Callahan, Surbhi Modi, Jennifer Swanson, Bernadette Ng'eno, Laura N Broyles
INTRODUCTION: HIV-infected pregnant and breastfeeding adolescents are a particularly vulnerable group that require special attention and enhanced support to achieve optimal maternal and infant outcomes. The objective of this paper is to review published evidence about antenatal care (ANC) service delivery and outcomes for HIV-infected pregnant adolescents in low-income country settings, identify gaps in knowledge and programme services and highlight the way forward to improve clinical outcomes of this vulnerable group...
August 4, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28782336/willingness-to-use-pre-exposure-prophylaxis-prep-for-hiv-prevention-among-men-who-have-sex-with-men-msm-in-malaysia-findings-from-a-qualitative-study
#20
Adam Bourne, Matteo Cassolato, Clayton Koh Thuan Wei, Bangyuan Wang, Joselyn Pang, Sin How Lim, Iskandar Azwa, Ilias Yee, Gitau Mburu
BACKGROUND: Men who have sex with men (MSM) continue to be disproportionately affected by HIV in Malaysia. Recent success has been observed within demonstration projects examining the efficacy of HIV pre-exposure prophylaxis (PrEP), an antiretroviral -based medication taken by HIV-negative men to prevent sero-conversion. In order for such promising findings to be translated in real-world settings, it is important to understand the acceptability of PrEP, including perceived barriers to access or uptake...
August 2, 2017: Journal of the International AIDS Society
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