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Journal of the International AIDS Society

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https://www.readbyqxmd.com/read/29130644/progress-towards-the-united-nations-90-90-90-and-95-95-95-targets-the-experience-in-british-columbia-canada
#1
Viviane D Lima, Martin St-Jean, Ignacio Rozada, Jean A Shoveller, Bohdan Nosyk, Robert S Hogg, Paul Sereda, Rolando Barrios, Julio S G Montaner
INTRODUCTION: Antiretroviral therapy (ART) scale-up is central to the global strategy to control the HIV/AIDS pandemic. To accelerate efforts towards ending the AIDS epidemic, the Joint United Nations Programme on HIV/AIDS released the 90-90-90 and 95-95-95 targets, which have recently been approved by the United Nations (UN). This study characterizes the province of British Columbia (BC)'s progress towards achieving the UN targets, predicts a trajectory up to 2030 according to each of the individual steps (i...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29130621/realizing-the-potential-of-routine-viral-load-testing-in-sub-saharan-africa
#2
EDITORIAL
Wafaa M El-Sadr, Miriam Rabkin, John Nkengasong, Deborah L Birx
No abstract text is available yet for this article.
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29130605/community-driven-demand-creation-for-the-use-of-routine-viral-load-testing-a-model-to-scale-up-routine-viral-load-testing
#3
Bactrin M Killingo, Trisa B Taro, Wame N Mosime
INTRODUCTION: HIV treatment outcomes are dependent on the use of viral load measurement. Despite global and national guidelines recommending the use of routine viral load testing, these policies alone have not translated into widespread implementation or sufficiently increased access for people living with HIV (PLHIV). Civil society and communities of PLHIV recognize the need to close this gap and to enable the scale up of routine viral load testing. METHODS: The International Treatment Preparedness Coalition (ITPC) developed an approach to community-led demand creation for the use of routine viral load testing...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29130601/scaling-up-hiv-viral-load-lessons-from-the-large-scale-implementation-of-hiv-early-infant-diagnosis-and-cd4-testing
#4
Trevor Peter, Clement Zeh, Zachary Katz, Ali Elbireer, Bereket Alemayehu, Lara Vojnov, Alex Costa, Naoko Doi, Ilesh Jani
INTRODUCTION: The scale-up of effective HIV viral load (VL) testing is an urgent public health priority. Implementation of testing is supported by the availability of accurate, nucleic acid based laboratory and point-of-care (POC) VL technologies and strong WHO guidance recommending routine testing to identify treatment failure. However, test implementation faces challenges related to the developing health systems in many low-resource countries. The purpose of this commentary is to review the challenges and solutions from the large-scale implementation of other diagnostic tests, namely nucleic-acid based early infant HIV diagnosis (EID) and CD4 testing, and identify key lessons to inform the scale-up of VL...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29119726/cotrimoxazole-prophylaxis-was-associated-with-enteric-commensal-bacterial-resistance-among-hiv-exposed-infants-in-a-randomized-controlled-trial-botswana
#5
Kathleen M Powis, Sajini Souda, Shahin Lockman, Gbolahan Ajibola, Kara Bennett, Jean Leidner, Michael D Hughes, Sikhulile Moyo, Erik van Widenfelt, Haruna B Jibril, Joseph Makhema, Max Essex, Roger L Shapiro
INTRODUCTION: Despite declining risk of vertical HIV transmission, prophylactic cotrimoxazole (CTX) remains widely used to reduce morbidity and mortality in the event of HIV infection among exposed infants, with an inherent risk of conferring commensal antimicrobial resistance. Using data from a randomized, placebo-controlled trial of infant CTX prophylaxis, we sought to quantify emergence of antibiotic resistance. METHODS: HIV-exposed uninfected infants enrolled in the Botswana Mpepu study were randomized to prophylactic CTX or placebo between 14 and 34 days of life and continued through 15 months...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29116684/disparities-in-direct-acting-antivirals-uptake-in-hiv-hepatitis-c-co-infected-populations-in-canada
#6
Sahar Saeed, Erin C Strumpf, Erica Em Moodie, Jim Young, Roy Nitulescu, Joseph Cox, Alexander Wong, Sharon Walmsely, Curtis Cooper, Marie-Lousie Vachon, Valerie Martel-Laferriere, Mark Hull, Brian Conway, Marina B Klein
BACKGROUND: Direct acting antivirals (DAAs) have revolutionized hepatitis C (HCV) treatment with >90% cure rates even in real-world studies, giving hope that HCV can be eliminated. However, for DAAs to have a population-level impact on the burden of HCV disease, treatment uptake needs to be expanded. We investigated temporal trends in HCV treatment uptake and evaluated factors associated with second-generation DAA initiation and efficacy among key HIV-HCV co-infected populations in Canada...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29105323/factors-associated-with-hiv-testing-among-young-men-who-have-sex-with-men-in-myanmar-a-cross-sectional-study
#7
Minh D Pham, Poe Poe Aung, Aye Kyawt Paing, Naanki Pasricha, Paul A Agius, Waimar Tun, Ashish Bajracharya, Stanley Luchters
INTRODUCTION: In Myanmar, men who have sex with men (MSM) experience high risk of HIV infection. However, access to HIV testing and prevention services remains a challenge among this marginalized population. The objective of this study was to estimate population prevalence and correlates of prior HIV testing among young MSM (YMSM) and informs the development of HIV testing and intervention programmes that respond to the specific needs of this population. METHODS: Five hundred and eighty-five YMSM aged 18 to 24 years were recruited using respondent-driven sampling (RDS) in a cross-sectional survey conducted in six townships of Myanmar...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29098809/gp41-and-gag-amino-acids-linked-to-hiv-1-protease-inhibitor-based-second-line-failure-in-hiv-1-subtype-a-from-western-kenya
#8
Mia Coetzer, Lauren Ledingham, Lameck Diero, Emmanuel Kemboi, Millicent Orido, Rami Kantor
INTRODUCTION: Failure of protease-inhibitor (PI)-based second-line antiretroviral therapy (ART) with medication adherence but no protease drug resistance mutations (DRMs) is not well understood. This study investigated the involvement of gp41 and gag as alternative mechanisms, not captured by conventional resistance testing and particularly relevant in resource-limited settings where third-line ART is limited. METHODS: We evaluated gp41 and gag for unique amino acids in seven subtype A infected Kenyans failing second-line therapy with no PI resistance yet detectable lopinavir (query dataset), compared to seven similar-setting patients with PI resistance or undetectable lopinavir and 69 publically available subtype A Kenyan whole-genomes sequences...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29091340/online-interventions-to-address-hiv-and-other-sexually-transmitted-and-blood-borne-infections-among-young-gay-bisexual-and-other-men-who-have-sex-with-men-a-systematic-review
#9
Rod Knight, Mohammad Karamouzian, Travis Salway, Mark Gilbert, Jean Shoveller
INTRODUCTION: Globally, young gay, bisexual and other men who have sex with men (gbMSM) continue to experience disproportionately high rates of HIV and other sexually transmitted and blood-borne infections (STBBIs). As such, there are strong public health imperatives to evaluate innovative prevention, treatment and care interventions, including online interventions. This study reviewed and assessed the status of published research (e.g. effectiveness; acceptability; differential effects across subgroups) involving online interventions that address HIV/STBBIs among young gbMSM...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29064168/high-prevalence-of-hiv-and-non-communicable-disease-ncd-risk-factors-in-rural-kwazulu-natal-south-africa
#10
Alastair van Heerden, Ruanne V Barnabas, Shane A Norris, Lisa K Micklesfield, Heidi van Rooyen, Connie Celum
INTRODUCTION: South Africa faces epidemics of HIV and non-communicable diseases (NCDs). The aim of this study was to characterize the prevalence of non-communicable disease risk factors and depression, stratified by HIV status, in a community with a high burden of HIV. METHODS: We conducted a home-based HIV counselling and testing study in KwaZulu-Natal, South Africa between November 2011 and June 2012. Contiguous households were approached and all adults ≥18 years old were offered an HIV test...
October 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29052344/brief-counselling-after-home-based-hiv-counselling-and-testing-strongly-increases-linkage-to-care-a-cluster-randomized-trial-in-uganda
#11
Eugene Ruzagira, Heiner Grosskurth, Anatoli Kamali, Kathy Baisley
INTRODUCTION: The aim of this study was to determine whether counselling provided subsequent to HIV testing and referral for care increases linkage to care among HIV-positive persons identified through home-based HIV counselling and testing (HBHCT) in Masaka, Uganda. METHODS: The study was an open-label cluster-randomized trial. 28 rural communities were randomly allocated (1:1) to intervention (HBHCT, referral and counselling at one and two months) or control (HBHCT and referral only)...
October 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29052340/absence-of-neurocognitive-disadvantage-associated-with-paediatric-hiv-subtype-a-infection-in-children-on-antiretroviral-therapy
#12
Paul Bangirana, Theodore D Ruel, Michael J Boivin, Satish K Pillai, Leila B Giron, Alla Sikorskii, Asish Banik, Jane Achan
INTRODUCTION: Infection with HIV subtype A has been associated with poorer neurocognitive outcomes compared to HIV subtype D in Ugandan children not eligible for antiretroviral therapy (ART). In this study, we sought to determine whether subtype-specific differences are also observed among children receiving ART. MATERIALS AND METHODS: Children were recruited from a clinical trial in which they were randomized to receive either lopinavir (LPV)- or non-nucleoside reverse transcriptase inhibitor (NNRTI)- based ART (NCT00978068)...
October 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29049854/role-of-community-based-research-in-advocating-hcv-prevention-and-care
#13
LETTER
Patrizia Carrieri, Perrine Roux
No abstract text is available yet for this article.
October 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28953328/twelve-year-mortality-in-adults-initiating-antiretroviral-therapy-in-south-africa
#14
Morna Cornell, Leigh F Johnson, Robin Wood, Frank Tanser, Matthew P Fox, Hans Prozesky, Michael Schomaker, Matthias Egger, Mary-Ann Davies, Andrew Boulle
INTRODUCTION: South Africa has the largest number of individuals living with HIV and the largest antiretroviral therapy (ART) programme worldwide. In September 2016, ART eligibility was extended to all 7.1 million HIV-positive South Africans. To ensure that further expansion of services does not compromise quality of care, long-term outcomes must be monitored. Few studies have reported long-term mortality in resource-constrained settings, where mortality ascertainment is challenging. Combining site records with data linked to the national vital registration system, sites in the International Epidemiology Databases to Evaluate AIDS Southern Africa collaboration can identify >95% of deaths in patients with civil identification numbers (IDs)...
September 25, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28953330/when-are-declines-in-condom-use-while-using-prep-a-concern-modelling-insights-from-a-hillbrow-south-africa-case-study
#15
Hannah Grant, Zindoga Mukandavire, Robyn Eakle, Holly Prudden, Gabriela B Gomez, Helen Rees, Charlotte Watts
INTRODUCTION: Oral pre-exposure prophylaxis (PrEP) is a promising new prevention approach for those most at risk of HIV infection. However, there are concerns that behavioural disinhibition, specifically reductions in condom use, might limit PrEP's protective effect. This study uses the case of female sex workers (FSWs) in Johannesburg, South Africa, to assess whether decreased levels of condom use following the introduction of PrEP may limit HIV risk reduction. METHOD: We developed a static model of HIV risk and compared HIV-risk estimates before and after the introduction of PrEP to determine the maximum tolerated reductions in condom use with regular partners and clients for HIV risk not to change...
September 20, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28953327/t-cells-with-low-cd2-levels-express-reduced-restriction-factors-and-are-preferentially-infected-in-therapy-na%C3%A3-ve-chronic-hiv-1-patients
#16
Sebastian Bolduan, Herwig Koppensteiner, Ramona Businger, Stephanie Rebensburg, Christine Kunze, Ruth Brack-Werner, Rika Draenert, Michael Schindler
INTRODUCTION: Restriction factors (RFs) suppress HIV-1 in cell lines and primary cell models. Hence, RFs might be attractive targets for novel antiviral strategies, but their importance for virus control in vivo is controversial. METHODS: We profiled the expression of RFs in primary blood-derived mononuclear cells (PBMC) from therapy-naïve HIV-1 patients and quantified infection. RESULTS: Overall, there was no correlation between individual RF expression and HIV-1 status in total PBMC...
September 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28953324/clinical-utility-of-hcv-core-antigen-detection-and-quantification-using-serum-samples-and-dried-blood-spots-in-people-who-inject-drugs-in-dar-es-salaam-tanzania
#17
Zameer Mohamed, Jessie Mbwambo, Yusuke Shimakawa, Lila Poiteau, Stéphane Chevaliez, Jean-Michel Pawlotsky, John Rwegasha, Sanjay Bhagani, Taylor-Robinson Simon D, Julie Makani, Mark R Thursz, Maud Lemoine
INTRODUCTION: A lack of access to hepatitis C virus (HCV) diagnostics is a significant barrier to achieving the World Health Organization 2030 global elimination goal. HCV core antigen (HCVcAg) quantification and dried blood spot (DBS) are appealing alternatives to conventional HCV serology and nucleic acid testing (NAT) for resource-constraint settings, particularly in difficult-to-reach populations. We assessed the accuracy of serum and DBS HCVcAg testing in people who inject drugs in Tanzania using HCV NAT as a reference...
September 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28953323/hiv-testing-and-the-care-continuum-among-transgender-women-population-estimates-from-rio-de-janeiro-brazil
#18
Emilia M Jalil, Erin C Wilson, Paula M Luz, Luciane Velasque, Ronaldo I Moreira, Cristiane V Castro, Laylla Monteiro, Ana Cristina F Garcia, Sandra W Cardoso, Lara E Coelho, Willi McFarland, Albert Y Liu, Valdilea G Veloso, Susan Buchbinder, Beatriz Grinsztejn
INTRODUCTION: Evidence suggests that, of all affected populations, transgender women (transwomen) may have the heaviest HIV burden worldwide. Little is known about HIV linkage and care outcomes for transwomen. We aimed to estimate population-level indicators of the HIV cascade of care continuum, and to evaluate factors associated with viral suppression among transwomen in Rio de Janeiro, Brazil. METHODS: We conducted a respondent-driven sampling (RDS) study of transwomen from August 2015 to January 2016 in Rio de Janeiro, Brazil and collected data on linkage and access to care, antiretroviral treatment and performed HIV viral load testing...
September 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28953322/a-historical-review-of-hiv-prevention-and-care-initiatives-in-british-columbia-canada-1996-2015
#19
Michelle Olding, Ben Enns, Dimitra Panagiotoglou, Jean Shoveller, P Richard Harrigan, Rolando Barrios, Thomas Kerr, Julio S G Montaner, Bohdan Nosyk
INTRODUCTION: British Columbia has made significant progress in the treatment and prevention of HIV since 1996, when Highly Active Antiretroviral Therapy (HAART) became available. However, we currently lack a historical summary of HIV prevention and care interventions implemented in the province since the introduction of HAART and how they have shaped the HIV epidemic. Guided by a socio-ecological framework, we present a historical review of biomedical and health services, community and structural interventions implemented in British Columbia from 1996-2015 to prevent HIV transmission or otherwise enhance the cascade of HIV care...
September 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28953326/scaling-a-waterfall-a-meta-ethnography-of-adolescent-progression-through-the-stages-of-hiv-care-in-sub-saharan-africa
#20
Shannon Williams, Jenny Renju, Ludovica Ghilardi, Alison Wringe
INTRODUCTION: Observational studies have shown considerable attrition among adolescents living with HIV across the "cascade" of HIV care in sub-Saharan Africa, leading to higher mortality rates compared to HIV-infected adults or children. We synthesized evidence from qualitative studies on factors that promote or undermine engagement with HIV services among adolescents living with HIV in sub-Saharan Africa. METHODS: We systematically searched five databases for studies published between 2005 and 2016 that met pre-defined inclusion criteria...
September 15, 2017: Journal of the International AIDS Society
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