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Journal of the International AIDS Society

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https://www.readbyqxmd.com/read/27989271/beyond-the-90-90-90-refocusing-hiv-prevention-as-part-of-the-global-hiv-response
#1
Rachel Baggaley, Shona Dalal, Cheryl Johnson, Virginia Macdonald, Ioannis Mameletzis, Michelle Rodolph, Carmen Figueroa, Julia Samuelson, Annette Verster, Meg Doherty, Gottfried Hirnschall
INTRODUCTION: The remarkable expansion in availability of antiretroviral therapy (ART) over the past two decades has transformed HIV infection into a manageable chronic condition. People with HIV infection now live long and healthy lives on treatment that is simpler, safer and cheaper. According to UNAIDS estimates, the global coverage of ART reached 46% in 2015, resulting in a 26% decrease in annual HIV-related deaths since 2010. Such success has positioned treatment access at the centre of the global HIV response as a way to prevent mortality, morbidity and HIV transmission through a "Treat All" approach...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27989270/from-policy-to-action-how-to-operationalize-the-treatment-for-all-agenda
#2
Francesca Celletti, Jennifer Cohn, Catherine Connor, Stephen Lee, Anja Giphart, Julio Montaner
No abstract text is available yet for this article.
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27978939/should-hiv-testing-for-all-pregnant-women-continue-cost-effectiveness-of-universal-antenatal-testing-compared-to-focused-approaches-across-high-to-very-low-hiv-prevalence-settings
#3
Naoko Ishikawa, Shona Dalal, Cheryl Johnson, Daniel R Hogan, Takuro Shimbo, Nathan Shaffer, Razia N Pendse, Ying-Ru Lo, Massimo N Ghidinelli, Rachel Baggaley
INTRODUCTION: HIV testing is the entry point for the elimination of mother-to-child transmission of HIV. Decreasing external funding for the HIV response in some low- and middle-income countries has triggered the question of whether a focused approach to HIV testing targeting pregnant women in high-burden areas should be considered. This study aimed at determining and comparing the cost-effectiveness of universal and focused HIV testing approaches for pregnant women across high to very low HIV prevalence settings...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27964776/-since-both-of-us-are-using-antiretrovirals-we-have-been-supportive-to-each-other-facilitators-and-barriers-of-pre-exposure-prophylaxis-use-in-heterosexual-hiv-serodiscordant-couples-in-kisumu-kenya
#4
Rena C Patel, Gaelen Stanford-Moore, Josephine Odoyo, Maria Pyra, Imeldah Wakhungu, Keerthana Anand, Elizabeth A Bukusi, Jared M Baeten, Joelle M Brown
INTRODUCTION: Since 2015, the World Health Organization recommends pre-exposure prophylaxis (PrEP) for all persons at substantial risk for HIV, including HIV-uninfected partners in serodiscordant relationships in resource-limited settings. As PrEP moves from clinical trials to real-world use, understanding facilitators of and barriers to PrEP initiation and adherence is critical to successful PrEP implementation and rollout. METHODS: We conducted 44 in-depth individual or couple interviews with 63 participants (30 without HIV and 33 with HIV) enrolled in the Partners Demonstration Project in Kisumu, Kenya, between August and September 2014...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27938646/increased-frequencies-of-cd8-cd57-t-cells-are-associated-with-antibody-neutralization-breadth-against-hiv-in-viraemic-controllers
#5
Christine D Palmer, Marisol Romero-Tejeda, Eileen P Scully, Ainsley Lockhart, Michael S Seaman, Ariel Goldenthal, Alicja Piechocka-Trocha, Bruce D Walker, Lori B Chibnik, Stephanie Jost, Filippos Porichis
INTRODUCTION: An effective prophylactic vaccine against HIV will need to elicit antibody responses capable of recognizing and neutralizing rapidly evolving antigenic regions. The immunologic milieu associated with development of neutralizing antibody breadth remains to be fully defined. In this study, we sought to identify immunological signatures associated with neutralization breadth in HIV controllers. We applied an immune monitoring approach to analyze markers of T cell and myeloid cell activation by flow cytometry, comparing broad neutralizers with low- and non-neutralizers using multivariate and univariate analyses...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27931519/high-prevalence-of-hiv-chlamydia-and-gonorrhoea-among-men-who-have-sex-with-men-and-transgender-women-attending-trusted-community-centres-in-abuja-and-lagos-nigeria
#6
Babajide Keshinro, Trevor A Crowell, Rebecca G Nowak, Sylvia Adebajo, Sheila Peel, Charlotte A Gaydos, Cristina Rodriguez-Hart, Stefan D Baral, Melissa J Walsh, Ogbonnaya S Njoku, Sunday Odeyemi, Teclaire Ngo-Ndomb, William A Blattner, Merlin L Robb, Manhattan E Charurat, Julie Ake
INTRODUCTION: Sexually transmitted infection (STI) and HIV prevalence have been reported to be higher amongst men who have sex with men (MSM) in Nigeria than in the general population. The objective of this study was to characterize the prevalence of HIV, chlamydia and gonorrhoea in this population using laboratory-based universal testing. METHODS: TRUST/RV368 represents a cohort of MSM and transgender women (TGW) recruited at trusted community centres in Abuja and Lagos, Nigeria, using respondent-driven sampling (RDS)...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27914186/reimagining-hiv-service-delivery-the-role-of-differentiated-care-from-prevention-to-suppression
#7
Anna Grimsrud, Helen Bygrave, Meg Doherty, Peter Ehrenkranz, Tom Ellman, Robert Ferris, Nathan Ford, Bactrin Killingo, Lynette Mabote, Tara Mansell, Annette Reinisch, Isaac Zulu, Linda-Gail Bekker
No abstract text is available yet for this article.
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27914185/use-of-peers-to-improve-adherence-to-antiretroviral-therapy-a-global-network-meta-analysis
#8
REVIEW
Steve Kanters, Jay Jh Park, Keith Chan, Nathan Ford, Jamie Forrest, Kristian Thorlund, Jean B Nachega, Edward J Mills
INTRODUCTION: It is unclear whether using peers can improve adherence to antiretroviral therapy (ART). To construct the World Health Organization's global guidance on adherence interventions, we conducted a systematic review and network meta-analysis to determine the effectiveness of using peers for achieving adequate adherence and viral suppression. METHODS: We searched for randomized clinical trials of peer-based interventions to promote adherence to ART in HIV populations...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27887669/couple-interdependence-impacts-hiv-related-health-behaviours-among-pregnant-couples-in-southwestern-kenya-a-qualitative-analysis
#9
Anna Joy Rogers, Lillian Achiro, Elizabeth A Bukusi, Abigail M Hatcher, Zachary Kwena, Pamela L Musoke, Janet M Turan, Elly Weke, Lynae A Darbes
INTRODUCTION: HIV infection is frequently transmitted within stable couple partnerships. In order to prevent HIV acquisition in HIV-negative couples, as well as improve coping in couples with an HIV-positive diagnosis, it has been suggested that interventions be aimed at strengthening couple relationships, in addition to addressing individual behaviours. However, little is known about factors that influence relationships to impact joint decision-making related to HIV. METHODS: We conducted qualitative in-depth interviews with 40 pregnant women and 40 male partners in southwestern Kenya, an area of high HIV prevalence...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27876454/will-the-global-hiv-response-fail-gay-and-bisexual-men-and-other-men-who-have-sex-with-men
#10
George Ayala, Glenn-Milo Santos
INTRODUCTION: Gay and bisexual men and other men who have sex with men are among the small number of groups for whom HIV remains uncontrolled worldwide. Although there have been recent and notable decreases in HIV incidence across several countries, prevalence and incidence is consistently higher or rising among men who have sex with men when compared with other groups. METHODS: In 2014, MSMGF (the Global Forum on MSM & HIV) conducted its third biennial Global Men's Health and Rights Study, an international, multilingual, web-based cross-sectional survey of men who have sex with men recruited through online convenience sampling...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27863535/towards-an-integrated-primary-and-secondary-hiv-prevention-continuum-for-the-united-states-a-cyclical-process-model
#11
Tim Horn, Jennifer Sherwood, Robert H Remien, Denis Nash, Judith D Auerbach
INTRODUCTION: Every new HIV infection is preventable and every HIV-related death is avoidable. As many jurisdictions around the world endeavour to end HIV as an epidemic, missed HIV prevention and treatment opportunities must be regarded as public health emergencies, and efforts to quickly fill gaps in service provision for all people living with and vulnerable to HIV infection must be prioritized. DISCUSSION: We present a novel, comprehensive, primary and secondary HIV prevention continuum model for the United States as a conceptual framework to identify key steps in reducing HIV incidence and improving health outcomes among those vulnerable to, as well as those living with, HIV infection...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27852420/prisoners-co-infected-with-tuberculosis-and-hiv-a-systematic-review
#12
REVIEW
Chantal L Edge, Emma J King, Kate Dolan, Martin McKee
INTRODUCTION: Almost from the beginning of the HIV epidemic in 1981, an association with tuberculosis (TB) was recognized. This association between HIV and TB co-infection has been particularly evident amongst prisoners. However, despite this, few studies of TB in prisons have stratified results by HIV status. Given the high prevalence of HIV-positive persons and TB-infected persons in prisons and the documented risk of TB in those infected with HIV, it is of interest to determine how co-infection varies amongst prison populations worldwide...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27836020/high-levels-of-pre-treatment-hiv-drug-resistance-and-treatment-failure-in-nigerian-children
#13
Ragna S Boerma, T Sonia Boender, Kim C E Sigaloff, Tobias F Rinke de Wit, Michael Boele van Hensbroek, Nicaise Ndembi, Titilope Adeyemo, Edamisan O Temiye, Akin Osibogun, Pascale Ondoa, Job C Calis, Alani Sulaimon Akanmu
INTRODUCTION: Pre-treatment HIV drug resistance (PDR) is an increasing problem in sub-Saharan Africa. Children are an especially vulnerable population to develop PDR given that paediatric second-line treatment options are limited. Although monitoring of PDR is important, data on the paediatric prevalence in sub-Saharan Africa and its consequences for treatment outcomes are scarce. We designed a prospective paediatric cohort study to document the prevalence of PDR and its effect on subsequent treatment failure in Nigeria, the country with the second highest number of HIV-infected children in the world...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27834182/marked-sex-differences-in-all-cause-mortality-on-antiretroviral-therapy-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis
#14
REVIEW
Sarah W Beckham, Chris Beyrer, Peter Luckow, Meg Doherty, Eyerusalem K Negussie, Stefan D Baral
INTRODUCTION: While women and girls are disproportionately at risk of HIV acquisition, particularly in low- and middle-income countries (LMIC), globally men and women comprise similar proportions of people living with HIV who are eligible for antiretroviral therapy. However, men represent only approximately 41% of those receiving antiretroviral therapy globally. There has been limited study of men's outcomes in treatment programmes, despite data suggesting that men living with HIV and engaged in treatment programmes have higher mortality rates...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27809960/transactional-sex-and-risk-for-hiv-infection-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#15
REVIEW
Joyce Wamoyi, Kirsten Stobeanau, Natalia Bobrova, Tanya Abramsky, Charlotte Watts
INTRODUCTION: Young women aged 15 to 24 years in sub-Saharan Africa continue to be disproportionately affected by HIV. A growing number of studies have suggested that the practice of transactional sex may in part explain women's heightened risk, but evidence on the association between transactional sex and HIV has not yet been synthesized. We set out to systematically review studies that assess the relationship between transactional sex and HIV among men and women in sub-Saharan Africa and to summarize the findings through a meta-analysis...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27802846/declining-trend-in-transmitted-drug-resistance-detected-in-a-prospective-cohort-study-of-acute-hiv-infection-in-bangkok-thailand
#16
Donn J Colby, Trevor A Crowell, Sunee Sirivichayakul, Suteeraporn Pinyakorn, Eugene Kroon, Khunthalee Benjapornpong, Jintana Intasan, Rapee Trichavaroj, Sodsai Tovanabutra, Merlin Robb, Praphan Phanuphak, Jintanat Ananworanich, Nittaya Phanuphak
INTRODUCTION: As availability of antiretroviral therapy expands in developing countries, the risk for transmission of drug-resistant HIV also increases. Patients with acute HIV infection (AHI) provide an opportunity for real-time monitoring of transmitted drug resistance (TDR). SEARCH 010/RV 254 study is a prospective, longitudinal study of AHI. This analysis was performed to characterize changes in TDR over time in persons enrolled in the AHI cohort. METHODS: Genotype testing for TDR mutations was performed on 229 subjects enrolled from 2009 to 2014...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27799076/correction-corrigendum
#17
(no author information available yet)
[This corrects the article DOI: 10.7448/IAS.19.1.21165.].
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27797320/interruptions-of-antiretroviral-therapy-in-children-and-adolescents-with-hiv-infection-in-clinical-practice-a-retrospective-cohort-study-in-the-usa
#18
Natella Rakhmanina, Kam S Lam, Jaclyn Hern, Heather A Young, Alex Walters, Amanda D Castel
INTRODUCTION: Changes in combination antiretroviral therapy (cART) throughout childhood challenge the continuity of paediatric HIV treatment. This study aimed to evaluate the prevalence of treatment interruption (TI), including lamivudine (3TC) monotherapy, and the relationship of TI to virologic and immunologic parameters in HIV-infected paediatric patients. METHODS: Nested within a prospective observational study of a city-wide cohort of HIV-infected persons in the District of Columbia, this sub-study collected retrospective data on antiretroviral therapy, enrolment (endpoint) and historic (lifelong) CD4 counts and HIV RNA viral load (VL) of the paediatric cohort...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27784509/retention-and-mortality-outcomes-from-a-community-supported-public-private-hiv-treatment-programme-in-myanmar
#19
Gitau Mburu, Aung Zayar Paing, Nwe Ni Myint, Win Di, Kaung Htet Thu, Mala Ram, Christopher J Hoffmann, Bangyuan Wang, Soe Naing
INTRODUCTION: There is a growing interest in the potential contribution the private sector can make towards increasing access to antiretroviral therapy (ART) in low- and middle-income settings. This article describes a public-private partnership that was developed to expand HIV care capacity in Yangon, Myanmar. The partnership was between private sector general practitioners (GPs) and a community-based non-governmental organization (International HIV/AIDS Alliance). METHODS: Retrospective analysis of 2119 patient records dating from March 2009 to April 2015 was conducted...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27780519/international-congress-of-drug-therapy-in-hiv-infection-23-26-october-2016-glasgow-uk
#20
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of the International AIDS Society
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