journal
MENU ▼
Read by QxMD icon Read
search

Journal of the International AIDS Society

journal
https://www.readbyqxmd.com/read/30394678/predictive-factors-associated-with-liver-fibrosis-and-steatosis-by-transient-elastography-in-patients-with-hiv-mono-infection-under-long-term-combined-antiretroviral-therapy
#1
Hugo Perazzo, Sandra W Cardoso, Carolyn Yanavich, Estevão P Nunes, Michelle Morata, Nathalia Gorni, Paula Simplicio da Silva, Claudia Cardoso, Cristiane Almeida, Paula Luz, Valdilea G Veloso, Beatriz Grinsztejn
INTRODUCTION: Non-alcoholic fatty liver disease is characterized by the presence of hepatic steatosis and can be associated with fibrosis progression, development of cirrhosis and liver-related complications. Data on the prevalence of liver fibrosis and steatosis in HIV patients remain contradictory in resource-limited settings. We aimed to describe the prevalence and factors associated with liver fibrosis and steatosis in patients with HIV mono-infection under long-term antiretroviral therapy (ART) in Rio de Janeiro, Brazil...
November 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30378274/repeated-rectal-application-of-a-hyperosmolar-lubricant-is-associated-with-microbiota-shifts-but-does-not-affect-prep-drug-concentrations-results-from-a-randomized-trial-in-men-who-have-sex-with-men
#2
Richard E Haaland, Jeffrey Fountain, Yingtian Hu, Angela Holder, Chuong Dinh, LaShonda Hall, Nicole A Pescatore, Sheila Heeke, Clyde E Hart, Jiahui Xu, Yi-Juan Hu, Colleen F Kelley
INTRODUCTION: Oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) is highly effective in preventing HIV infection among men who have sex with men (MSM). The effects of consistent personal lubricant use in the rectum on tissue PrEP drug concentrations and the rectal microbiota are unknown. We investigated rectal PrEP drug concentrations and the microbiota in MSM before and after repeated rectal application of a hyperosmolar lubricant. METHODS: We randomized 60 HIV-negative MSM to apply 4 mL of hyperosmolar rectal lubricant daily (n = 20), take daily oral TDF/FTC (n = 19), or both (n = 21) for seven days...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30362663/hiv-glasgow-2018-28-31-october-2018-glasgow-uk
#3
(no author information available yet)
No abstract text is available yet for this article.
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30362662/internalized-hiv-stigma-art-initiation-and-hiv-1-rna-suppression-in-south-africa-exploring-avoidant-coping-as-a-longitudinal-mediator
#4
Valerie A Earnshaw, Laura M Bogart, Jean-Philippe Laurenceau, Brian T Chan, Brendan G Maughan-Brown, Janan J Dietrich, Ingrid Courtney, Gugulethu Tshabalala, Catherine Orrell, Glenda E Gray, David R Bangsberg, Ingrid T Katz
INTRODUCTION: Cross-sectional evidence suggests that internalized HIV stigma is associated with lower likelihoods of antiretroviral therapy (ART) initiation and HIV-1 RNA suppression among people living with HIV (PLWH). This study examined these associations with longitudinal data spanning the first nine months following HIV diagnosis and explored whether avoidant coping mediates these associations. METHODS: Longitudinal data were collected from 398 South African PLWH recruited from testing centres in 2014 to 2015...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30350406/regional-differences-between-people-who-inject-drugs-in-an-hiv-prevention-trial-integrating-treatment-and-prevention-hptn-074-a-baseline-analysis
#5
Kathryn E Lancaster, Irving F Hoffman, Brett Hanscom, Tran Viet Ha, Kostyantyn Dumchev, Hepa Susami, Scott Rose, Vivian F Go, Sarah A Reifeis, Katie R Mollan, Michael G Hudgens, Estelle M Piwowar-Manning, Paul Richardson, Sergii Dvoriak, Zubairi Djoerban, Tetiana Kiriazova, Oleksandr Zeziulin, Samsuridjal Djauzi, Chu Viet Ahn, Carl Latkin, David Metzger, David N Burns, Jeremy Sugarman, Steffanie A Strathdee, Susan H Eshleman, William Clarke, Deborah Donnell, Lynda Emel, Lisa E Sunner, Laura McKinstry, Nirupama Sista, Erica L Hamilton, Jonathan P Lucas, Bui D Duong, Nguyen Van Vuong, Riza Sarasvita, William C Miller
INTRODUCTION: People who inject drugs (PWID) experience high HIV incidence and face significant barriers to engagement in HIV care and substance use treatment. Strategies for HIV treatment as prevention and substance use treatment present unique challenges in PWID that may vary regionally. Understanding differences in the risk structure for HIV transmission and disease progression among PWID is essential in developing and effectively targeting intervention strategies of HIV treatment as prevention...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30350392/successes-and-challenges-in-optimizing-the-viral-load-cascade-to-improve-antiretroviral-therapy-adherence-and-rationalize-second-line-switches-in-swaziland
#6
David Etoori, Iza Ciglenecki, Mpumelelo Ndlangamandla, Celeste G Edwards, Kiran Jobanputra, Munyaradzi Pasipamire, Gugu Maphalala, Chunfu Yang, Inoussa Zabsonre, Serge M Kabore, Javier Goiri, Roger Teck, Bernhard Kerschberger
INTRODUCTION: As antiretroviral therapy (ART) is scaled up, more patients become eligible for routine viral load (VL) monitoring, the most important tool for monitoring ART efficacy. For HIV programmes to become effective, leakages along the VL cascade need to be minimized and treatment switching needs to be optimized. However, many HIV programmes in resource-constrained settings report significant shortfalls. METHODS: From a public sector HIV programme in rural Swaziland, we evaluated the VL cascade of adults (≥18 years) on ART from the time of the first elevated VL (>1000 copies/mL) between January 2013 and June 2014 to treatment switching by December 2015...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30350345/bioinformatic-data-processing-pipelines-in-support-of-next-generation-sequencing-based-hiv-drug-resistance-testing-the-winnipeg-consensus
#7
Hezhao Ji, Eric Enns, Chanson J Brumme, Neil Parkin, Mark Howison, Emma R Lee, Rupert Capina, Eric Marinier, Santiago Avila-Rios, Paul Sandstrom, Gary Van Domselaar, Richard Harrigan, Roger Paredes, Rami Kantor, Marc Noguera-Julian
INTRODUCTION: Next-generation sequencing (NGS) has several advantages over conventional Sanger sequencing for HIV drug resistance (HIVDR) genotyping, including detection and quantitation of low-abundance variants bearing drug resistance mutations (DRMs). However, the high HIV genomic diversity, unprecedented large volume of data, complexity of analysis and potential for error pose significant challenges for data processing. Several NGS analysis pipelines have been developed and used in HIVDR research; however, the absence of uniformity in data processing strategies results in lack of consistency and comparability of outputs from different pipelines...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334610/collateral-benefits-how-the-practical-application-of-good-participatory-practice-can-strengthen-hiv-research-in-sub-saharan-africa
#8
Deborah Baron, Thandekile Essien, Sinazo Pato, Miliswa Magongo, Nomthandazo Mbandazayo, Fiona Scorgie, Helen Rees, Sinead Delany-Moretlwe
INTRODUCTION: The Good Participatory Practice (GPP): Guidelines for Biomedical HIV Prevention Trials, second edition (2011) were developed to provide clinical trial sponsors and implementers with a formal stakeholder engagement framework. As one of the largest African research institutes, Wits Reproductive Health and HIV Institute (Wits RHI) became an early adopter of GPP by implementing its principles within large-scale national and regional clinical trials. This article examines Wits RHI's lessons learned from implementing GPP, its ongoing efforts to institutionalize GPP, and the yet to be realized potential in creating fully sustainable structures for meaningful stakeholder engagement in HIV prevention research, implementation science and beyond...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334609/power-to-participants-a-call-for-person-centred-hiv-prevention-services-and-research
#9
Marija Pantelic, Christine Stegling, Sally Shackleton, Enrique Restoy
INTRODUCTION: While biomedical HIV prevention offers promise for preventing new HIV infections, access to and uptake of these technologies remain unacceptably low in some settings. New models for delivery of HIV prevention are clearly needed. This commentary highlights the potential of person-centred programming and research for increasing the cultural relevance, applicability and use of efficacious HIV prevention strategies. It calls for a shift in perspective within HIV prevention programmes and research, whereby people are recognized for their agency rather than assumed to be passive beneficiaries or research participants...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334608/it-is-not-just-about-the-trial-the-critical-role-of-effective-engagement-and-participatory-practices-for-moving-the-hiv-research-field-forward
#10
EDITORIAL
Kathleen M MacQueen, Judith D Auerbach
No abstract text is available yet for this article.
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334604/strengthening-stakeholder-engagement-through-ethics-review-in-biomedical-hiv-prevention-trials-opportunities-and-complexities
#11
REVIEW
Catherine Slack, Abigail Wilkinson, Jessica Salzwedel, Paul Ndebele
INTRODUCTION: Clinical trials of biomedical HIV prevention modalities require the cooperation of multiple stakeholders. Key stakeholders, such as community members, may have stark vulnerabilities. Consequently, calls for HIV prevention researchers to implement "stakeholder engagement" are increasingly common. Such engagement is held to benefit inter-stakeholder relations, stakeholders themselves and the research itself. The ethics review process presents a unique opportunity to strengthen stakeholder engagement practices in HIV prevention trials...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334601/using-theory-of-change-frameworks-to-develop-evaluation-strategies-for-research-engagement-results-of-a-pre-pilot-study
#12
Kathleen M MacQueen, Natalie T Eley, Mike Frick, Carol Hamilton
INTRODUCTION: Inadequate community and stakeholder engagement can lead to accusations that research is unethical and can delay or slow research or translation of results to practice. Such experiences have led major funders as well as regulatory and advisory bodies to establish minimal requirements for community and stakeholder engagement in HIV and other clinical research. However, systematic efforts to formally evaluate the contributions and impact of particular practices are lacking...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334600/building-effective-multilevel-hiv-prevention-partnerships-with-black-men-who-have-sex-with-men-experience-from-hptn-073-a-pre-exposure-prophylaxis-study-in-three-us-cities
#13
Darrell P Wheeler, Jonathan Lucas, Leo Wilton, LaRon E Nelson, Christopher Hucks-Ortiz, C Chauncey Watson, Craig Hutchinson, Kenneth H Mayer, Irene Kuo, Manya Magnus, Geetha Beauchamp, Steven Shoptaw, Lynda Marie Emel, Ying Q Chen, Lisa Hightow-Weidman, Sheldon D Fields
No abstract text is available yet for this article.
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334379/qualitative-research-on-community-experiences-in-large-hiv-research-trials-what-have-we-learned
#14
Carol S Camlin, Janet Seeley
INTRODUCTION: Very few pragmatic and community-level effectiveness trials integrate the use of qualitative research over all stages of the trial, to inform trial design, implementation optimization, results interpretation and post-trial policy recommendations. This is despite the growing demand for mixed methods research from funding agencies and awareness of the vital importance of qualitative and mixed methods research for understanding trial successes and challenges. DISCUSSION: We offer examples from work we have been involved in to illustrate how qualitative research conducted within trials can reveal vital contextual factors that influence implementation and outcomes, can enable an informed adaptation of trials as they are being conducted and can lead to the formulation of theory regarding the social and behavioural pathways of intervention, while also enabling community engagement in trial design and implementation...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334377/village-community-mobilization-is-associated-with-reduced-hiv-incidence-in-young-south-african-women-participating-in-the-hptn-068-study-cohort
#15
Sheri A Lippman, Anna M Leddy, Torsten B Neilands, Jennifer Ahern, Catherine MacPhail, Ryan G Wagner, Dean Peacock, Rhian Twine, Dana E Goin, F Xavier Gómez-Olivé, Amanda Selin, Stephen M Tollman, Kathleen Kahn, Audrey Pettifor
INTRODUCTION: Adolescent girls and young women (AGYW) in South Africa bear a disproportionate burden of HIV. Community mobilization (CM), defined as community members taking collective action to achieve a common goal related to health, equity and rights, has been associated with increased HIV testing and condom use and has been called a 'critical enabler' for addressing the HIV epidemic. However, limited research has examined whether CM is associated with HIV incidence among AGYW. METHODS: We examine the association of CM with incident HIV among AGYW (ages 13 to 21) enrolled in the HPTN 068 cohort in the Agincourt Health and socio-Demographic Surveillance System, South Africa...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30334358/stakeholder-engagement-to-inform-hiv-clinical-trials-a-systematic-review-of-the-evidence
#16
REVIEW
Suzanne Day, Meredith Blumberg, Thi Vu, Yang Zhao, Stuart Rennie, Joseph D Tucker
INTRODUCTION: Stakeholder engagement is an essential component of HIV clinical trials. We define stakeholder engagement as an input by individuals or groups with an interest in HIV clinical trials to inform the design or conduct of said trials. Despite its value, stakeholder engagement to inform HIV clinical trials has not been rigorously examined. The purpose of our systematic review is to examine stakeholder engagement for HIV clinical trials and compare it to the recommendations of the UNAIDS/AVAC Good Participatory Practice (GPP) guidelines...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30318851/-optima-attempts-to-objectively-and-pragmatically-assist-countries-meet-their-targets-most-efficiently-and-effectively
#17
LETTER
David P Wilson, Marelize Gorgens, David J Wilson
No abstract text is available yet for this article.
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30318848/-my-future-is-bright%C3%A2-i-won-t-die-with-the-cause-of-aids-ten-year-patient-art-outcomes-and-experiences-in-south-africa
#18
Cheryl J Hendrickson, Sophie J S Pascoe, Amy N Huber, Aneesa Moolla, Mhairi Maskew, Lawrence C Long, Matthew P Fox
INTRODUCTION: South Africa is moving into a new era of HIV treatment with "treat all" policies where people may be on treatment for most of their lives. We need to understand treatment outcomes and facilitators of long-term antiretroviral treatment (ART) adherence and retention-in-care in the South African context. In one of the first studies to investigate long-term treatment outcomes in South Africa, we aimed to describe ten-year patient outcomes at a large public-sector HIV clinic in Johannesburg and explore patient experiences of the treatment programme over this time in order to ascertain factors that may aid or hinder long-term adherence and retention...
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30318715/hiv-95-95-95-and-the-allocative-efficiency-fallacy-why-treating-everyone-makes-sense-from-a-humanitarian-clinical-economic-and-disease-control-perspective
#19
LETTER
Reuben Granich, Somya Gupta, Brian G Williams
No abstract text is available yet for this article.
October 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/30303293/older-people-with-hiv-are-an-essential-part-of-the-continuum-of-hiv-care
#20
Eugenia L Siegler, Chelsie O Burchett, Marshall J Glesby
No abstract text is available yet for this article.
October 2018: Journal of the International AIDS Society
journal
journal
42065
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"