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Metallomics: Integrated Biometal Science

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https://www.readbyqxmd.com/read/28650043/heme-containing-enzymes-and-inhibitors-for-tryptophan-metabolism
#1
REVIEW
Daojing Yan, Ying-Wu Lin, Xiangshi Tan
Iron-containing enzymes such as heme enzymes play crucial roles in biological systems. Three distinct heme-containing dioxygenase enzymes, tryptophan 2,3-dioxygenase (TDO), indoleamine 2,3-dioxygenase 1 (IDO1) and indoleamine 2,3-dioxygenase 2 (IDO2) catalyze the initial and rate-limiting step of l-tryptophan catabolism through the kynurenine pathway in mammals. Overexpression of these enzymes causes depletion of tryptophan and the accumulation of metabolic products, which contributes to tumor immune tolerance and immune dysregulation in a variety of disease pathologies...
June 26, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28644490/potentiating-role-of-copper-on-spatial-memory-deficit-induced-by-beta-amyloid-and-evaluation-of-mitochondrial-function-markers-in-the-hippocampus-of-rats
#2
Ladan Behzadfar, Mohammad Abdollahi, Omid Sabzevari, Rohollah Hosseini, Ahmad Salimi, Parvaneh Naserzadeh, Mohammad Sharifzadeh, Jalal Pourahmad
Mounting evidence suggests that copper, a crucial element in normal brain function, plays an important role in the etiology of Alzheimer's disease, which is known as a neurodegenerative mitochondrial disorder. However, the precise mechanisms of its effects on cognitive and mitochondrial functions through the CNS have not been thoroughly recognized yet. In this study, we aimed to investigate the long-term (3-week) effects of copper sulfate (50, 100 and 200 mg kg(-1) day(-1)) exposure on learning and memory as well as on mitochondrial function in the hippocampus of rats in the presence and absence of beta amyloid (1 μg μl(-1) per side) intrahippocampally (IH)...
June 23, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28636040/tamoxifen-like-metallocifens-target-the-thioredoxin-system-determining-mitochondrial-impairment-leading-to-apoptosis-in-jurkat-cells
#3
Valeria Scalcon, Michèle Salmain, Alessandra Folda, Siden Top, Pascal Pigeon, Hui Zhi Shirley Lee, Gérard Jaouen, Alberto Bindoli, Anne Vessières, Maria Pia Rigobello
Tamoxifen-like metallocifens (TLMs) of the group-8 metals (Fe, Ru, and Os) show strong anti-proliferative activity on cancer cell lines resistant to apoptosis, owing to their unique redox properties. In contrast, the thioredoxin system, which is involved in cellular redox balance, is often overexpressed in cancer cells, especially in tumour types resistant to standard chemotherapies. Therefore, we investigated the effect of these three TLMs on the thioredoxin system and evaluated the input of the metallocene unit in comparison with structurally related organic tamoxifens...
June 21, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28636017/effect-of-cisplatin-on-the-transport-activity-of-pii-type-atpases
#4
Francesco Tadini-Buoninsegni, Giacomo Sordi, Serena Smeazzetto, Giovanni Natile, Fabio Arnesano
Cisplatin (cis-diamminedichlorido-Pt(ii)) is extensively used as a chemotherapeutic agent against various types of tumors. However, cisplatin administration causes serious side effects, including nephrotoxicity, ototoxicity and neurotoxicity. It has been shown that cisplatin can interact with P-type ATPases, e.g., Cu(+)-ATPases (ATP7A and ATP7B) and Na(+),K(+)-ATPase. Cisplatin-induced inhibition of Na(+),K(+)-ATPase has been related to the nephrotoxic effect of the drug. To investigate the inhibitory effects of cisplatin on the pumping activity of PII-type ATPases, electrical measurements were performed on sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) and Na(+),K(+)-ATPase embedded in vesicles/membrane fragments adsorbed on a solid-supported membrane...
June 21, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28620665/influence-of-iron-metabolism-on-manganese-transport-and-toxicity
#5
REVIEW
Qi Ye, Jo Eun Park, Kuljeet Gugnani, Swati Betharia, Alejandro Pino-Figueroa, Jonghan Kim
Although manganese (Mn) is critical for the proper functioning of various metabolic enzymes and cofactors, excess Mn in the brain causes neurotoxicity. While the exact transport mechanism of Mn has not been fully understood, several importers and exporters for Mn have been identified over the past decade. In addition to Mn-specific transporters, it has been demonstrated that iron transporters can mediate Mn transport in the brain and peripheral tissues. However, while the expression of iron transporters is regulated by body iron stores, whether or not disorders of iron metabolism modify Mn homeostasis has not been systematically discussed...
June 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28620661/brutus-and-its-paralogs-bts-like1-and-bts-like2-encode-important-negative-regulators-of-the-iron-deficiency-response-in-arabidopsis-thaliana
#6
Maria N Hindt, Garo Z Akmakjian, Kara L Pivarski, Tracy Punshon, Ivan Baxter, David E Salt, Mary Lou Guerinot
Iron (Fe) is required for plant health, but it can also be toxic when present in excess. Therefore, Fe levels must be tightly controlled. The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Loss of both of these E3 ligases enhances tolerance to Fe deficiency. We further generated a triple mutant with loss of both BTS paralogs and a partial loss of BTS expression that exhibits even greater tolerance to Fe-deficient conditions and increased Fe accumulation without any resulting Fe toxicity effects...
June 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28613326/arbuscular-mycorrhizal-fungi-enhance-the-copper-tolerance-of-tagetes-patula-through-the-sorption-and-barrier-mechanisms-of-intraradical-hyphae
#7
Xishi Zhou, Lei Fu, Yan Xia, Luqing Zheng, Chen Chen, Zhenguo Shen, Yahua Chen
Arbuscular mycorrhizal fungi (AMF) are widespread soil fungi that can form endosymbiotic structures with the root systems of most plants and can improve the tolerance of host plants to heavy metals. In the present study, we investigated the effects of AMF (Glomus coronatum) inoculation on the tolerance of Tagetes patula L. to Cu. Almost all of the non-mycorrhizal plants exposed to 100 μM Cu died after 3 d, whereas phytotoxicity was only observed in mycorrhizal plants that were exposed to Cu concentrations greater than 100 μM...
June 14, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28607992/no-dependent-programmed-cell-death-is-involved-in-the-formation-of-zn-related-lesions-in-tobacco-leaves
#8
Aleksandra Weremczuk, Anna Ruszczyńska, Ewa Bulska, Danuta Maria Antosiewicz
A recent study indicated that the development of lesions on the leaf blades of tobacco exposed to zinc (Zn) excess can be considered a manifestation of a Zn-tolerance strategy at the organ level. Here, we investigated whether cell death leading to the formation of localized lesions is destructive in character (necrosis type) or results from programmed self-induced cell death (PCD). Selected parameters, including PCD markers, were determined in the leaves from tobacco plants grown in the presence of 200 μM Zn and compared with control conditions...
June 13, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28604884/ferrous-iron-efflux-systems-in-bacteria
#9
REVIEW
Hualiang Pi, John D Helmann
Bacteria require iron for growth, with only a few reported exceptions. In many environments, iron is a limiting nutrient for growth and high affinity uptake systems play a central role in iron homeostasis. However, iron can also be detrimental to cells when it is present in excess, particularly under aerobic conditions where its participation in Fenton chemistry generates highly reactive hydroxyl radicals. Recent results have revealed a critical role for iron efflux transporters in protecting bacteria from iron intoxication...
June 12, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28598481/pools-of-cadmium-in-chlamydomonas-reinhardtii-revealed-by-chemical-imaging-and-xas-spectroscopy
#10
F Penen, M P Isaure, D Dobritzsch, I Bertalan, H Castillo-Michel, O Proux, E Gontier, P Le Coustumer, D Schaumlöffel
The green micro-alga Chlamydomonas reinhardtii is commonly used as a model to investigate metallic stress in photosynthetic organisms. The aim of this study was to explore processes implemented by three C. reinhardtii strains to cope with cadmium (Cd), and particularly to evidence Cd sequestration in the cell. For that, we used a combination of subcellular fractionation and chemical imaging (micro X-ray fluorescence (μXRF) and transmission electron microscopy (TEM/X-EDS)) to identify subcellular compartments of Cd accumulation, and X-ray absorption spectroscopy (XAS) to determine chemical Cd speciation...
June 9, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28594012/biosynthetic-considerations-of-triscatechol-siderophores-framed-on-serine-and-threonine-macrolactone-scaffolds
#11
REVIEW
Zachary L Reitz, Moriah Sandy, Alison Butler
Bacteria often produce siderophores to facilitate iron uptake. One of the most studied siderophores is enterobactin, the macrolactone trimer of 2,3-dihydroxybenzoyl-l-serine, produced by E. coli and many other enteric bacteria. Other siderophores are variants of enterobactin, with structural modifications including expansion of the tri-serine core to a tetra-serine macrolactone, substitution of l-serine with l-threonine, insertion of amino acids (i.e., Gly, l-Ala, d-Lys, d- and l-Arg, l-Orn), catechol glucosylation, and linearization of the tri-serine macrolactone core...
June 8, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28581009/decoding-the-anticancer-activity-of-vo-clioquinol-compound-the-mechanism-of-action-and-cell-death-pathways-in-human-osteosarcoma-cells
#12
Ignacio E León, Paula Díez, Enrique J Baran, Susana B Etcheverry, Manuel Fuentes
Vanadium compounds were studied in recent years by considering them as a representative of a new class of non-platinum metal anticancer drugs. However, a few challenges still remain in the discovery of new molecular targets of these new metallodrugs. Studies on cell signaling pathways related to vanadium compounds have scarcely been reported and so far this information is highly critical for identifying novel targets that play a key role in the antitumor actions of vanadium complexes. This research deals with the alterations in the intracellular signaling pathways promoted by an oxovanadium(iv) complex with the clioquinol (5-chloro-7-iodo-8-quinolinol), VO(CQ)2, on a human osteosarcoma cell line (MG-63)...
June 5, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28573291/mechanisms-of-iron-and-copper-frataxin-interactions
#13
T H L Han, J M Camadro, R Santos, E Lesuisse, J M El Hage Chahine, N T Ha-Duong
Frataxin is a mitochondrial protein whose deficiency is the cause of Friedreich's ataxia, a hereditary neurodegenerative disease. This protein plays a role in iron-sulfur cluster biosynthesis, protection against oxidative stress and iron metabolism. In an attempt to provide a better understanding of the role played by metals in its metabolic functions, the mechanisms of mitochondrial metal binding to frataxin in vitro have been investigated. A purified recombinant yeast frataxin homolog Yfh1 binds two Cu(ii) ions with a Kd1(Cu(II)) of 1...
June 2, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28561859/human-calprotectin-affects-the-redox-speciation-of-iron
#14
Toshiki G Nakashige, Elizabeth M Nolan
We report that the metal-sequestering human host-defense protein calprotectin (CP, S100A8/S100A9 oligomer) affects the redox speciation of iron (Fe) in bacterial growth media and buffered aqueous solution. Under aerobic conditions and in the absence of an exogenous reducing agent, CP-Ser (S100A8(C42S)/S100A9(C3S) oligomer) depletes Fe from three different bacterial growth media preparations over a 48 h timeframe (T = 30 °C). The presence of the reducing agent β-mercaptoethanol accelerates this process and allows CP-Ser to deplete Fe over a ≈1 h timeframe...
May 31, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28561856/la-iii-biodistribution-profiles-from-intravenous-and-oral-dosing-of-two-lanthanum-complexes-la-dpp-3-and-la-xt-and-evaluation-as-treatments-for-bone-resorption-disorders
#15
D M Weekes, J F Cawthray, M Rieder, J Syeda, M Ali, E Wasan, T I Kostelnik, B O Patrick, A Panahifar, A Al-Dissi, D Cooper, K M Wasan, C Orvig
Trivalent lanthanum (La(3+)) has the potential to treat bone resorption disorders (such as osteoporosis) by eliciting a bone-building response in the cells which control skeletal remodelling. Because La(3+) suffers from extremely poor intestinal absorption, specifically designed chelators are required in order that a biologically active form of lanthanum can be administered orally. Two such chelators, 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdpp) and bis-{[bis(carboxymethyl)amino]methy}phosphinic acid (H5XT), have previously been the subjects of extensive physical, in vitro, and in vivo testing as the tris- and mono-lanthanum(iii) complexes La(dpp)3 and La(XT), respectively...
May 31, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28561851/reactivity-of-u-associated-osteopontin-with-lactoferrin-a-one-to-many-complex
#16
Sarah Ameziane-Le Hir, Damien Bourgeois, Christian Basset, Agnès Hagège, Claude Vidaud
Uranium is the heaviest natural element, mainly found in aqueous medium as the hexavalent uranyl ion (UO2(2+)). Bones are the main organs in which uranium accumulates, depending on as yet unknown molecular and cellular mechanisms. Recently, it has been revealed that osteopontin (OPN), a protein involved in bio-mineralization processes, and its main naturally occurring cleaved form (fOPN), have nanomolar affinities for UO2(2+). The binding of UO2(2+) is due to both the phosphorylation sites and acidic residues of these proteins and is accompanied by a slight gain in secondary structure...
May 31, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28466891/analogues-of-desferrioxamine-b-designed-to-attenuate-iron-mediated-neurodegeneration-synthesis-characterisation-and-activity-in-the-mptp-mouse-model-of-parkinson-s-disease
#17
Michael P Gotsbacher, Thomas J Telfer, Paul K Witting, Kay L Double, David I Finkelstein, Rachel Codd
Parkinson's disease (PD) is a neurodegenerative disorder characterised by the death of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the brain and formation of α-synuclein-containing intracellular inclusions. Excess intraneuronal iron in the SNpc increases reactive oxygen species (ROS), which identifies removing iron as a possible therapeutic strategy. Desferrioxamine B (DFOB, 1) is an iron chelator produced by bacteria. Its high Fe(iii) affinity, water solubility and low chronic toxicity is useful in removing iron accumulated in plasma from patients with transfusion-dependent blood disorders...
May 3, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28573267/correction-iron-isotopic-composition-of-blood-serum-in-anemia-of-chronic-kidney-disease
#18
Yulia Anoshkina, Marta Costas-Rodríguez, Marijn Speeckaert, Wim Van Biesen, Joris Delanghe, Frank Vanhaecke
Correction for 'Iron isotopic composition of blood serum in anemia of chronic kidney disease' by Yulia Anoshkina et al., Metallomics, 2017, DOI: 10.1039/c7mt00021a.
June 21, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28573266/the-workings-of-ferritin-a-crossroad-of-opinions
#19
Wilfred R Hagen, Peter-Leon Hagedoorn, Kourosh Honarmand Ebrahimi
Biochemistry of the essential element iron is complicated by radical chemistry associated with Fe(ii) ions and by the extremely low solubility of the Fe(iii) ion in near-neutral water. To mitigate these problems cells from all domains of life synthesize the protein ferritin to take up and oxidize Fe(ii) and to form a soluble storage of Fe(iii) from which iron can be made available for physiology. A long history of studies on ferritin has not yet resulted in a generally accepted mechanism of action of this enzyme...
June 21, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28548666/zinc-and-the-iron-donor-frataxin-regulate-oligomerization-of-the-scaffold-protein-to-form-new-fe-s-cluster-assembly-centers
#20
B K Galeano, W Ranatunga, O Gakh, D Y Smith, J R Thompson, G Isaya
Early studies of the bacterial Fe-S cluster assembly system provided structural details for how the scaffold protein and the cysteine desulfurase interact. This work and additional work on the yeast and human systems elucidated a conserved mechanism for sulfur donation but did not provide any conclusive insights into the mechanism for iron delivery from the iron donor, frataxin, to the scaffold. We previously showed that oligomerization is a mechanism by which yeast frataxin (Yfh1) can promote assembly of the core machinery for Fe-S cluster synthesis both in vitro and in cells, in such a manner that the scaffold protein, Isu1, can bind to Yfh1 independent of the presence of the cysteine desulfurase, Nfs1...
June 21, 2017: Metallomics: Integrated Biometal Science
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