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Metallomics: Integrated Biometal Science

Yasen Maimaitiyiming, Chao Wang, Shi Xu, Khairul Islam, Ye Jia Chen, Chang Yang, Qian Qian Wang, Hua Naranmandura
Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). However, it is unclear whether the biotransformation of arsenic by AS3MT contributes to the promotion of acute promyelocytic leukemia (APL) therapy. In order to understand the probable role of AS3MT in APL patients, we evaluated the effects of arsenite (iAsIII) and three mixed arsenicals (i...
May 18, 2018: Metallomics: Integrated Biometal Science
Isabelle Rohn, Talke Anu Marschall, Nina Kroepfl, Kenneth Bendix Jensen, Michael Aschner, Simon Tuck, Doris Kuehnelt, Tanja Schwerdtle, Julia Bornhorst
The essential micronutrient selenium (Se) is required for various systemic functions, but its beneficial range is narrow and overexposure may result in adverse health effects. Additionally, the chemical form of the ingested selenium contributes crucially to its health effects. While small Se species play a major role in Se metabolism, their toxicological effects, bioavailability and metabolic transformations following elevated uptake are poorly understood. Utilizing the tractable invertebrate Caenorhabditis elegans allowed for an alternative approach to study species-specific characteristics of organic and inorganic Se forms in vivo, revealing remarkable species-dependent differences in the toxicity and bioavailability of selenite, selenomethionine (SeMet) and Se-methylselenocysteine (MeSeCys)...
May 17, 2018: Metallomics: Integrated Biometal Science
Zhepeng Sun, Zhe Xu, Dongxu Wang, Haidong Yao, Shu Li
Selenium (Se) deficiency inhibits immune cell differentiation, affects immune response, and leads to cellular and humoral immune dysfunction. However, the impact of Se deficiency on the differentiation and Th1/Th2 balance of dendritic cells is still unclear. In this study, we replicated a model of Se-deficient chickens by feeding the chickens with a low-Se diet (i.e., the content of Se is 0.008 mg per kg diet). On this basis, we explored the effect of Se deficiency on the differentiation of chicken dendritic cells by induction culture of peripheral blood monocyte cells...
May 16, 2018: Metallomics: Integrated Biometal Science
Brech Aikman, Andreia de Almeida, Samuel M Meier-Menches, Angela Casini
Aquaporins (AQPs) are membrane proteins allowing permeation of water, glycerol & hydrogen peroxide across biomembranes, and playing an important role in water homeostasis in different organs, exocrine gland secretion, urine concentration, skin moisturization, fat metabolism and neural signal transduction. Notably, a large number of studies showed that AQPs are closely associated with cancer biological functions and expressed in more than 20 human cancer cell types. Furthermore, AQP expression is positively correlated with tumour types, grades, proliferation, migration, angiogenesis, as well as tumour-associated oedema, rendering these membrane channels attractive as both diagnostic and therapeutic targets in cancer...
May 16, 2018: Metallomics: Integrated Biometal Science
Wei Li, Milton Talukder, Xue-Tong Sun, Cong Zhang, Xue-Nan Li, Jing Ge, Jin-Long Li
Selenoprotein W (SelW) is an important member of the avian selenoprotein family. It is well known for its important role in protecting neurons from oxidative stress during neuronal development. d-Amino acid (d-serine), as a neurotransmitter in the central nervous system (CNS), can mediate neurotoxicity. d-Amino acid oxidase (DAAO) is responsible for regulating the d-serine levels in cells. However, the correlation between SelW and DAAO is not clear yet. To investigate the regulations between SelW and DAAO, chicken embryo monolayer neurons were treated with d-serine and/or Se...
May 16, 2018: Metallomics: Integrated Biometal Science
Verónica Demicheli, Diego M Moreno, Rafael Radi
Human MnSOD is a homotetramer and represents an essential mitochondrial antioxidant enzyme, which catalyzes the dismutation of superoxide radicals (O2˙-) at near diffusion-controlled rates. Under a variety of disease conditions and in the process of aging, nitric oxide (˙NO) can outcompete MnSOD and react with O2˙- to yield the potent oxidant peroxynitrite (ONOO-). Then, peroxynitrite can promote the regio-specific nitration of MnSOD at active site tyrosine 34, which turns the enzyme inactive. In this review we assess the kinetic aspects of the formation of peroxynitrite in the presence of MnSOD and the biochemical mechanisms of peroxynitrite-mediated MnSOD nitration...
May 8, 2018: Metallomics: Integrated Biometal Science
Carolin Mügge, Elena Michelucci, Francesca Boscaro, Chiara Gabbiani, Luigi Messori, Wolfgang Weigand
Correction for 'Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(ii) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage' by Carolin Mügge et al., Metallomics, 2011, 3, 987-990.
May 3, 2018: Metallomics: Integrated Biometal Science
Yao Tian, Tiantian Fang, Siming Yuan, Yuchuan Zheng, Fabio Arnesano, Giovanni Natile, Yangzhong Liu
Cisplatin is a widely used anticancer drug in clinic, and ammonium tetrathiomolybdate ([(NH4)2MoS4], TM) is a copper chelator used in clinic for the treatment of Wilson's disease. Recently, TM has been found to enhance the therapeutic effect of cisplatin; however, the origin of this effect is not clear. Here we found that TM can inhibit the reaction of cisplatin with Cu-Atox1 and prevent the protein unfolding and aggregation induced by cisplatin. Although Ag(i) binds to Atox1 in a way similar to Cu(i)-Atox1, TM does not prevent the reaction of Ag-Atox1 with cisplatin...
May 3, 2018: Metallomics: Integrated Biometal Science
Daisy L Wong, Martin J Stillman
cis-Diamminedichloroplatinum(ii) (cisplatin), a powerful chemotherapeutic, can incur chemoresistance in cancers, reducing therapeutic success. Metallothioneins (MTs) are suspected of metallodrug interference via ligand removal and metal sequestration. The mechanistic details and reactions rates kobs for the systematic deconstruction of cisplatin by apo-human MT are reported and analysed from mass spectral data.
April 24, 2018: Metallomics: Integrated Biometal Science
Shina Hussain, Diann Andrews, Bruce C Hill
Silver has long been used as an antimicrobial agent in general and medicinal use. Here, we observe that exposure of the Gram-positive, endospore-forming bacterium Bacillus subtilis to Ag(i) effects growth in a biphasic manner. In the first phase at Ag(i) concentrations below 50 μM B. subtilis growth is not affected, but activity of the respiratory enzyme cytochrome c oxidase is disrupted completely. Between 50 to 100 μM Ag(i) B. subtilis growth is drastically diminished and completely absent above 100 μM Ag(i)...
April 20, 2018: Metallomics: Integrated Biometal Science
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April 19, 2018: Metallomics: Integrated Biometal Science
Stefan K Kolev, Petko St Petkov, Miroslav A Rangelov, Dimitar V Trifonov, Teodor I Milenov, Georgi N Vayssilov
Alkaline and alkaline earth ions, namely Na+, K+, Mg2+ and Ca2+, are critical for the stability, proper folding and functioning of RNA. Moreover, those metal ions help to facilitate macromolecular interactions as well as the formation of supramolecular structures (e.g. the ribosome and the ribozymes). Therefore, identifying the interactions between ions and nucleic acids is a key to the better comprehension of the physical nature and biological functions of those biomolecules. The scope of this review is to highlight the preferential location and binding sites of alkaline and alkaline earth metal ions compensating the negatively charged backbone of nucleic acids and interacting with other electronegative centers, focusing on RNA...
April 18, 2018: Metallomics: Integrated Biometal Science
Marius Spohn, Simone Edenhart, Mohammad Alanjary, Nadine Ziemert, Daniel Wibberg, Jörn Kalinowski, Timo H J Niedermeyer, Evi Stegmann, Wolfgang Wohlleben
The mechanism of siderophore-mediated iron supply enhances fitness and survivability of microorganisms under iron limited growth conditions. One class of naturally occurring ionophores is the small aminopolycarboxylic acids (APCAs). Although they are structurally related to the most famous anthropogenic chelating agent, ethylenediaminetetraacetate (EDTA), they have been largely neglected by the scientific community. Here, we demonstrate the detection of APCA gene clusters by a computational screening of a nucleotide database...
April 18, 2018: Metallomics: Integrated Biometal Science
Isaac J Carney, Jacek L Kolanowski, Zelong Lim, Benjamin Chekroun, Angela G Torrisi, Trevor W Hambley, Elizabeth J New
Iron dysregulation is implicated in numerous diseases, and iron homeostasis is profoundly influenced by the labile iron pool (LIP). Tools to easily observe changes in the LIP are limited, with calcein AM-based assays most widely used. We describe here FlCFe1, a ratiometric analogue of calcein AM, which also provides the capacity for imaging iron in 3D cell models.
April 16, 2018: Metallomics: Integrated Biometal Science
Emmanuel Pourcelot, Marine Lénon, Peggy Charbonnier, Fiona Louis, Pascal Mossuz, Jean-Marc Moulis
In animal cells the specific translational control of proteins contributing to iron homeostasis is mediated by the interaction between the Iron Regulatory Proteins (IRP1 and IRP2) and the Iron Responsive Elements (IRE) located in the untranslated regions (UTR) of regulated messengers, such as those encoding ferritin or the transferrin receptor. The absolute concentrations of the components of this regulatory system in hematopoietic cells and the ability of the endogenous IRP to regulate exogenous IRE have been measured...
April 13, 2018: Metallomics: Integrated Biometal Science
Xueting Yan, Bin He, Lihong Liu, Guangbo Qu, Jianbo Shi, Ligang Hu, Guibin Jiang
Silver nanoparticles (AgNPs) are the nanomaterials most widely used as antimicrobial agents in a range of consumer products, due to the environmental release of either the AgNPs themselves or silver ions. Although AgNPs appear to be more potent than silver ions, the mechanism behind the activity is not fully elucidated yet. The most common mechanism of toxicity of AgNPs proposed to date is the release of silver ions and/or the particle-specific functions. In this study, Pseudomonas aeruginosa (a model for Gram-negative bacteria) was treated with AgNPs, and its proteomic response was comprehensively characterized to elucidate the antimicrobial mechanism of AgNPs in the microorganism...
April 11, 2018: Metallomics: Integrated Biometal Science
Florence Mus, Alexander B Alleman, Natasha Pence, Lance C Seefeldt, John W Peters
Most biological nitrogen fixation (BNF) results from the activity of the molybdenum nitrogenase (Mo-nitrogenase, Nif), an oxygen-sensitive metalloenzyme complex found in all known diazotrophs. Two alternative forms of nitrogenase, the vanadium nitrogenase (V-nitrogenase, Vnf) and the iron-only nitrogenase (Fe-only nitrogenase, Anf) have also been identified in the genome of some organisms that encode for Nif. It has been suggested that alternative nitrogenases were responsible for N2-fixation on early Earth because oceans were depleted of bioavailable Mo...
April 9, 2018: Metallomics: Integrated Biometal Science
Eriko Hori, Sakura Yoshida, Takeshi Fuchigami, Mamoru Haratake, Morio Nakayama
As an essential micronutrient, selenium deficiency is a leading cause of cardiovascular diseases. The heart is continuously beating to deliver blood to the entire body, and this requires a high amount of energy. An adult heart normally obtains 50-70% of its adenosine 5'-triphosphate from fatty acid β-oxidation. An increase in fatty acid oxidation activity induces the generation of larger amounts of by-products (reactive oxygen species, ROS) from mitochondrial oxidative phosphorylation. Selenium-dependent glutathione peroxidases play a critical role in the removal of these ROS, especially organic hydroperoxides, from the heart...
March 26, 2018: Metallomics: Integrated Biometal Science
Kourosh Honarmand Ebrahimi
RSAD2 (cig-5), also known as viperin (virus inhibitory protein, endoplasmic reticulum associated, interferon inducible), is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes. Since the discovery of this enzyme more than a decade ago, numerous studies have shown that it exhibits antiviral activity against a wide range of viruses. However, there is no clear picture demonstrating the mechanism by which RSAD2 restricts the replication process of different viruses, largely because there is no direct evidence describing its in vivo enzymatic activity...
March 23, 2018: Metallomics: Integrated Biometal Science
Agnieszka Drozd, Dominika Wojewska, Manuel David Peris-Díaz, Piotr Jakimowicz, Artur Krężel
Metallothioneins (MTs), small cysteine-rich proteins, present in four major isoforms, are key proteins involved in zinc and copper homeostasis in mammals. To date, only one X-ray crystal structure of a MT has been solved. It demonstrates seven bivalent metal ions bound in two structurally independent domains with M4S11 (α) and M3S9 (β) clusters. Recent discoveries indicate that Zn(ii) ions are bound with MT2 with the range from nano- to picomolar affinity, which determines its cellular zinc buffering properties that are demonstrated by the presence of partially Zn(ii)-depleted MT2 species...
March 21, 2018: Metallomics: Integrated Biometal Science
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