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Metallomics: Integrated Biometal Science

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https://www.readbyqxmd.com/read/28937159/duodenal-cytochrome-b-cybrd1-ferric-reductase-functional-studies-in-cells
#1
F Schlottmann, M Vera-Aviles, G O Latunde-Dada
Dietary non-heme ferric iron is reduced by the ferric reductase enzyme, duodenal cytochrome b (Dcytb), before absorption by the divalent metal transporter 1 (DMT1). A single nucleotide polymorphism (SNP rs10455 mutant) that is located in the last exon of the Dcytb gene was reported in C282Y haemochromatosis HFE subjects. The present work therefore investigated the phenotype of this mutant Dcytb in Chinese hamster ovary (CHO) cells. These cultured cells were transfected with either wild type (WT) or the SNP vector plasmids of Dcytb...
September 22, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28932850/amino-and-chloro-8-hydroxyquinolines-and-their-copper-complexes-as-proteasome-inhibitors-and-antiproliferative-agents
#2
Valentina Oliveri, Valeria Lanza, Danilo Milardi, Maurizio Viale, Irena Maric, Carmelo Sgarlata, Graziella Vecchio
Proliferation and programmed cell death are tightly correlated with the ubiquitin-proteasome system (UPS). Alterations in the UPS may be implicated in pathological conditions such as the proteasome over-activity in cancer cells. Mounting evidence indicates that many types of actively proliferating malignant cells are more sensitive to proteasome inhibition than normal cells, and therefore UPS inhibitors are actively pursued as anticancer agents. The approval of the proteasome inhibitor drug bortezomib for the treatment of myeloma and lymphoma further highlights the need for UPS inhibitors...
September 21, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28932845/sulphur-fertilization-influences-the-sulphur-species-composition-in-allium-sativum-sulphomics-using-hplc-icpms-ms-esi-ms-ms
#3
Andrea Raab, Marilena Ronzan, Joerg Feldmann
Garlic (A. sativum) contains a large number of small sulphur (S)-containing metabolites, which are important for its taste and smell and vary with A. sativum variety and growth conditions. This study was designed to investigate the influence of different sulphur-fertilization regimes on low molecular weight S-species by attempting the first sulphur mass balance in A. sativum roots and bulbs using HPLC-ICPMS/MS-ESI-MS/MS. Species unspecific quantification of acid soluble S-containing metabolites was achieved using HPLC-ICP-MS/MS...
September 21, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28914315/tyr25-tyr58-and-trp133-of-escherichia-coli-bacterioferritin-transfer-electrons-between-iron-in-the-central-cavity-and-the-ferroxidase-centre
#4
Justin M Bradley, Dimitri A Svistunenko, Geoffrey R Moore, Nick E Le Brun
Ferritins are 24meric proteins that overcome problems of toxicity, insolubility and poor bioavailability of iron in all types of cells by storing it in the form of a ferric mineral within their central cavities. In the bacterioferritin (BFR) from Escherichia coli iron mineralization kinetics have been shown to be dependent on an intra-subunit catalytic diiron cofactor site (the ferroxidase centre), three closely located aromatic residues and an inner surface iron site. One of the aromatic residues, Tyr25, is the site of formation of a transient radical, but the roles of the other two residues, Tyr58 and Trp133, are unknown...
September 15, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28913538/differences-in-cisplatin-distribution-in-sensitive-and-resistant-ovarian-cancer-cells-a-tem-nanosims-study
#5
Ronald F S Lee, Tina Riedel, Stéphane Escrig, Catherine Maclachlan, Graham W Knott, Curt A Davey, Kai Johnsson, Anders Meibom, Paul J Dyson
Cisplatin is a widely used anti-cancer drug, but its effect is often limited by acquired resistance to the compound during treatment. Here, we use a combination of transmission electron microscopy (TEM) and nanoscale-secondary ion mass spectrometry (NanoSIMS) to reveal differences between cisplatin uptake in human ovarian cancers cells, which are known to be susceptible to acquired resistance to cisplatin. Both cisplatin sensitive and resistant cell lines were studied, revealing markedly less cisplatin in the resistant cell line...
September 15, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28901367/effects-of-developmental-arsenite-exposure-on-hippocampal-synapses-in-mouse-offspring
#6
Fenghong Zhao, Yingjun Liao, Hongge Tang, Jie Piao, Gaoyang Wang, Yaping Jin
Arsenic exposure through drinking water can impair the learning and memory ability of children in China and other countries. Synaptic plasticity plays a key role in the process of learning and memory. Alterations in the expression of presynaptic and postsynaptic proteins can be used to evaluate synaptic plasticity, and further to evaluate impairment in learning and memory ability. Thereby, the aim of this study was to explore the mechanisms underlying arsenic neurotoxicity by focusing on alterations in the hippocampal synapses of mouse offspring induced by developmental arsenite exposure...
September 13, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28885630/from-direct-to-indirect-lithium-targets-a-comprehensive-review-of-omics-data
#7
REVIEW
Magali Roux, Anthony Dosseto
Metal ions are critical to a wide range of biological processes. Among them, lithium (Li) has been recognised for its benefit as a treatment for bipolar disorder (BD). However, we are yet to grasp the extent of its role in biological processes, despite its molecular targets having been extensively studied. Here we review a wide range of transcriptomic, proteomic and metabolomic studies in order to obtain a full picture of Li effects at various levels. Multifarious patterns of Li-regulated genes, proteins and metabolites are identified...
September 8, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28879348/the-elemental-role-of-iron-in-dna-synthesis-and-repair
#8
REVIEW
Sergi Puig, Lucía Ramos-Alonso, Antonia María Romero, María Teresa Martínez-Pastor
Iron is an essential redox element that functions as a cofactor in many metabolic pathways. Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases, nucleases, glycosylases, demethylases) and ribonucleotide reductase, use iron as an indispensable cofactor to function. Recent striking results have revealed that the catalytic subunit of DNA polymerases also contains conserved cysteine-rich motifs that bind iron-sulfur (Fe/S) clusters that are essential for the formation of stable and active complexes...
September 7, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28831476/phenylarsine-oxide-pao-induces-apoptosis-in-hepg2-cells-via-ros-mediated-mitochondria-and-er-stress-dependent-signaling-pathways
#9
Ping Huang, Yu Hua Zhang, Xiao Wei Zheng, Yu Jia Liu, Hong Zhang, Luo Fang, Yi Wen Zhang, Chang Yang, Khairul Islam, Chao Wang, Hua Naranmandura
Arsenic trioxide (As2O3) is an old drug that has recently been reintroduced as a therapeutic agent for acute promyelocytic leukemia (APL). Although As2O3 is also applied to treat other types of cancer in vitro and in vivo, it has been reported that single agent As2O3 has poor efficacy against non-hematologic malignant cancers in clinical trials. Recently, a few reports have indicated that organic arsenic compounds can be a possible alternative for the treatment of As2O3-resistant cancers. In this study, we aimed to investigate whether the organic arsenic compound phenylarsine oxide (PAO) has potent cytotoxic effects against human hepatocellular carcinoma (HCC) HepG2 cells...
August 23, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28702572/recent-structural-insights-into-the-function-of-copper-nitrite-reductases
#10
REVIEW
Sam Horrell, Demet Kekilli, Richard W Strange, Michael A Hough
Copper nitrite reductases (CuNiR) carry out the first committed step of the denitrification pathway of the global nitrogen cycle, the reduction of nitrite (NO2(-)) to nitric oxide (NO). As such, they are of major agronomic and environmental importance. CuNiRs occur primarily in denitrifying soil bacteria which carry out the overall reduction of nitrate to dinitrogen. In this article, we review the insights gained into copper nitrite reductase (CuNiR) function from three dimensional structures. We particularly focus on developments over the last decade, including insights from serial femtosecond crystallography using X-ray free electron lasers (XFELs) and from the recently discovered 3-domain CuNiRs...
July 12, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28675215/cellular-copper-homeostasis-current-concepts-on-its-interplay-with-glutathione-homeostasis-and-its-implication-in-physiology-and-human-diseases
#11
REVIEW
Ashima Bhattacharjee, Kaustav Chakraborty, Aditya Shukla
Copper is a trace element essential for almost all living organisms. But the level of intracellular copper needs to be tightly regulated. Dysregulation of cellular copper homeostasis leading to various diseases demonstrates the importance of this tight regulation. Copper homeostasis is regulated not only within the cell but also within individual intracellular compartments. Inactivation of export machinery results in excess copper being redistributed into various intracellular organelles. Recent evidence suggests the involvement of glutathione in playing an important role in regulating copper entry and intracellular copper homeostasis...
July 4, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28671201/the-transferrin-receptor-the-cellular-iron-gate
#12
REVIEW
Elena Gammella, Paolo Buratti, Gaetano Cairo, Stefania Recalcati
The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis. Since the number of TfR1 molecules at the cell surface is the rate-limiting step for iron entry into cells and is essential to prevent iron overload, TfR1 expression is precisely controlled at multiple levels. In this review, we have discussed the latest advances in the molecular regulation of TfR1 expression and we have considered current understanding of TfR1 function beyond its canonical role in providing iron for erythroid precursors and rapidly proliferating cells...
July 3, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28665435/the-role-of-the-zinc-transporter-slc30a2-znt2-in-transient-neonatal-zinc-deficiency
#13
REVIEW
Yarden Golan, Taiho Kambe, Yehuda G Assaraf
Breast milk is the optimal nutrient mix for infants until the age of 6 months. However, in some cases, due to genetic alterations as well as nutrient deficiencies in nursing mothers, infants may suffer from inadequate levels of micronutrients upon exclusive breastfeeding. In this respect, transient neonatal zinc deficiency (TNZD) is caused by loss-of-function mutations in the zinc transporter SLC30A2/ZnT2 gene, resulting in poor secretion of zinc into the breast milk. Consequently, infants exclusively breastfed with zinc-deficient breast milk develop severe zinc deficiency...
June 30, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28929149/contents-list
#14
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28929148/front-cover
#15
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28929147/back-cover
#16
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28869270/proteomic-and-genetic-analysis-of-the-response-of-s-cerevisiae-to-soluble-copper-leads-to-improvement-of-the-antimicrobial-function-of-cellulosic-copper-nanoparticles
#17
Xiaoqing Rong-Mullins, Matthew J Winans, Justin B Lee, Zachery R Lonergan, Vincent A Pilolli, Lyndsey M Weatherly, Thomas W Carmenzind, Lihua Jiang, Jonathan R Cumming, Gloria S Oporto, Jennifer E G Gallagher
Copper (Cu) was used in antiquity to prevent waterborne and food diseases because, as a broad-spectrum antimicrobial agent, it generates reactive oxygen species, ROS. New technologies incorporating Cu into low-cost biodegradable nanomaterials built on cellulose, known as cellulosic cupric nanoparticles or c-CuNPs, present novel approaches to deliver Cu in a controlled manner to control microbial growth. We challenged strains of Saccharomyces cerevisiae with soluble Cu and c-CuNPs to evaluate the potential of c-CuNPs as antifungal agents...
September 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28820536/atp7a-and-atp7b-regulate-copper-homeostasis-in-developing-male-germ-cells-in-mice
#18
Mateusz Ogórek, Małgorzata Lenartowicz, Rafał Starzyński, Aneta Jończy, Robert Staroń, Andrzej Doniec, Wojciech Krzeptowski, Aleksandra Bednarz, Olga Pierzchała, Paweł Lipiński, Zenon Rajfur, Zbigniew Baster, Patrycja Gibas-Tybur, Paweł Grzmil
The maintenance of copper homeostasis is critical for all cells. As learned from mice with disturbed copper metabolism, this trace element is also important for spermatogenesis. The experiments conducted in yeasts have demonstrated that appropriate copper level must be preserved to enable meiosis progression; however, increased copper level is toxic for cells. This study aims to analyze the expression profile of Atp7a and Atp7b and other genes encoding copper-related proteins during spermatogenesis in mice...
September 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28805879/downregulation-of-hepatic-multi-drug-resistance-protein-1-mdr1-after-copper-exposure
#19
Sara Reinartz Groba, Sarah Guttmann, Christoph Niemietz, Friedrich Bernick, Vanessa Sauer, Oliver Hachmöller, Uwe Karst, Hans Zischka, Andree Zibert, Hartmut H Schmidt
Copper homeostasis is strictly regulated in mammalian cells. We investigated the adaptation of hepatocytes after long-term copper exposure. Copper-resistant hepatoma HepG2 cell lines lacking ATP7B were generated. Growth, copper accumulation, gene expression, and transport were determined. Hepatocyte-like cells derived from a Wilson disease (WD) patient and the liver of a WD animal model were also studied. The rapidly gained copper resistance was found to be stable, as subculturing of cells in the absence of added copper (weaning) did not restore copper sensitivity...
September 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28795724/chronic-exposure-to-inorganic-mercury-induces-biochemical-and-morphological-changes-in-the-salivary-glands-of-rats
#20
W A B Aragão, N M M da Costa, N C F Fagundes, M C F Silva, S M Alves-Junior, J J V Pinheiro, L L Amado, M E Crespo-López, C S F Maia, R R Lima
Mercury exposure is considered to be a public health problem due to the generation of toxic effects on human health as a result of environmental and occupational conditions. The inorganic form of mercury (HgCl2) can cause several biological changes in cells and tissues through its cumulative toxic potential, but little has been experimentally proven about the effects of inorganic mercury on salivary glands, an important modulator organ of oral health. This study analyzes the effects of prolonged low dose exposure to HgCl2 on the salivary glands of rats...
September 20, 2017: Metallomics: Integrated Biometal Science
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