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Metallomics: Integrated Biometal Science

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https://www.readbyqxmd.com/read/28530295/dose-and-chemical-species-specific-effects-of-selenium-against-arsenite-toxicity-in-cultured-hepatocytes-of-rainbow-trout-oncorhynchus-mykiss
#1
Ankur Jamwal, Som Niyogi
The present study evaluated the mechanistic underpinnings of the interactive effects of selenium (Se), both inorganic (selenite) and organic (selenomethionine (SeMet)), against arsenite (As-III) cytotoxicity using rainbow trout (Oncorhynchus mykiss) hepatocytes in primary culture. Arsenite is known to induce cytotoxic effects by disrupting cellular redox homeostasis. In contrast, Se is essential for the maintenance of cellular anti-oxidative machinery, but when present above a threshold concentration, can also induce reactive oxygen species (ROS) generation and cause oxidative damage...
May 22, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28518204/integrated-metabolomics-and-metallomics-analyses-in-acute-coronary-syndrome-patients
#2
Xuejiao Yin, Leonardo Pinto de Carvalho, Mark Y Chan, Sam Fong Yau Li
Acute coronary syndrome (ACS) is the leading cause of morbidity and mortality. Accurate risk prediction in ACS patients is critically important for helping clinicians make therapeutic decisions, such as recommending a more aggressive intervention and intensive follow-up. However, risk stratification in ACS patients remains challenging, and the identification of novel predictors is necessary for improving the prognostic prediction in ACS patients. We employed metallomics and untargeted metabolomics approaches to discover new biomarkers from the plasma samples of 20 ACS patients and 20 non-ACS patients...
May 18, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28516990/cross-talk-between-neurometals-and-amyloidogenic-proteins-at-the-synapse-and-the-pathogenesis-of-neurodegenerative-diseases
#3
REVIEW
M Kawahara, M Kato-Negishi, K Tanaka
Increasing evidence suggests that disruption of metal homeostasis contributes to the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease, prion diseases, Lewy body diseases, and vascular dementia. Conformational changes of disease-related proteins (amyloidogenic proteins), such as β-amyloid protein, prion proteins, and α-synuclein, are well-established contributors to neurotoxicity and to the pathogenesis of these diseases. Recent studies have demonstrated that these amyloidogenic proteins are metalloproteins that bind trace elements, including zinc, iron, copper, and manganese, and play significant roles in the maintenance of metal homeostasis...
May 18, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28513634/mitochondria-targeted-platinum-ii-complexes-dual-inhibitory-activities-on-tumor-cell-proliferation-and-migration-invasion-via-intracellular-trafficking-of-%C3%AE-catenin
#4
Jingling Li, Xiaoli He, Yeling Zou, Dandan Chen, Liecheng Yang, Jiaming Rao, Huabing Chen, Michael C W Chan, Lin Li, Zhengqing Guo, Leshuai W Zhang, Chunying Chen
Mitochondria-targeted therapy is an alternative strategy for cancer therapy and may overcome the problems of metastasis and drug resistance that usually occur in conventional treatment. In this work, we demonstrate the mitochondria-targeted delivery of a cationic cyclometalated platinum(ii) complex, PIP-platin, in cancer cells. PIP-platin showed selective delivery and accumulation in the mitochondria and exhibited toxicity against a variety of tumor cell lines. The mitochondria were disrupted by PIP-platin, along with the generation of reactive oxygen species, depolarization of mitochondrial membrane potential, release of cytochrome c and necrosis...
May 17, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28504297/elemental-bioimaging-by-means-of-la-icp-oes-investigation-of-the-calcium-sodium-and-potassium-distribution-in-tobacco-plant-stems-and-leaf-petioles
#5
G M Thyssen, M Holtkamp, H Kaulfürst-Soboll, C A Wehe, M Sperling, A von Schaewen, U Karst
Laser ablation-inductively coupled plasma-optical emission spectroscopy (LA-ICP-OES) is presented as a valuable tool for elemental bioimaging of alkali and earth alkali elements in plants. Whereas LA-ICP-OES is commonly used for micro analysis of solid samples, laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) has advanced to the gold standard for bioimaging. However, especially for easily excitable and ubiquitous elements such as alkali and earth alkali elements, LA-ICP-OES holds some advantages regarding simultaneous detection, costs, contamination, and user-friendliness...
May 15, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28503683/cellular-evaluation-of-diselenonicotinamide-dsna-as-a-radioprotector-against-cell-death-and-dna-damage
#6
M Raghuraman, Prachi Verma, Amit Kunwar, Prasad P Phadnis, V K Jain, K Indira Priyadarsini
Diselenonicotinamide (DSNA), a synthetic organoselenium compound, was evaluated for its radioprotective effect in cellular models. A clonogenic assay in Chinese Hamster Ovary (CHO) cells and an apoptosis assay in murine splenic lymphocytes indicated that pre-treatment with DSNA at a concentration of 25 μM significantly protected them from radiation-induced cell death. Upon irradiation (1-12 Gy), dose-response studies were carried out under similar treatment conditions, and its dose modification factor (DMF) was estimated to be 1...
May 15, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28489098/correction-distinctive-hippocampal-zinc-distribution-patterns-following-stress-exposure-in-an-animal-model-of-ptsd
#7
Hagit Sela, Hagit Cohen, Zeev Karpas, Yehuda Zeiri
Correction for 'Distinctive hippocampal zinc distribution patterns following stress exposure in an animal model of PTSD' by Hagit Sela et al., Metallomics, 2017, 9, 323-333.
May 10, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28488724/complex-effect-of-zinc-oxide-nanoparticles-on-cadmium-chloride-induced-hepatotoxicity-in-mice-protective-role-of-metallothionein
#8
Shang Gao, Xue Wang, Shasha Wang, Shanshan Zhu, Rui Rong, Xiaolong Xu
The wide range of applications of ZnO nanoparticles (nano ZnO) in commercial products and the ubiquitous cadmium (Cd) contamination in the natural environment increase the chance of co-existence of nano ZnO with Cd in the surroundings. To investigate the effects of nano ZnO on CdCl2-induced hepatotoxicity in mice, the histopathologic changes, metallothionein expression, oxidative stress responses and serum biochemical parameters were determined after oral administration of bulk or nano ZnO and/or CdCl2 for seven consecutive days...
May 10, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28488704/targeting-curcumin-to-specific-tumour-cell-environments-the-influence-of-ancillary-ligands
#9
A Glenister, C K J Chen, E M Tondl, D Paterson, T W Hambley, A K Renfrew
Tumour-activation of prodrugs has the potential to improve the efficacy of anticancer agents while minimising systemic toxicity. Cobalt complexes are of interest in this respect as chaperones to deliver and release anticancer agents in the low oxygen, reducing environment of solid tumours. In addition to being able to release a cytotoxic ligand under the conditions of the tumour microenvironment, it is fundamental that the chaperone complex must also be able to penetrate through multiple cell layers to deliver the cytotoxin to all regions of the tumour...
May 10, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28480907/metabolomic-analysis-of-the-effects-of-cadmium-and-copper-treatment-in-oryza-sativa-l-using-untargeted-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry-and-all-ion-fragmentation
#10
Meritxell Navarro-Reig, Joaquim Jaumot, Benjamín Piña, Encarnación Moyano, Maria Teresa Galceran, Romà Tauler
While the knowledge of plant metabolomes has increased in the last few years, their response to the presence of toxicants is still poorly understood. Here, we analyse the metabolomic changes in Japanese rice (Oryza sativa var. Japonica) upon exposure to heavy metals (Cd(ii) and Cu(ii)) in concentrations from 10 to 1000 μM. After harvesting, rice metabolites were extracted from aerial parts of the plants and analysed by HPLC (HILIC TSK gel amide-80 column) coupled to a mass spectrometer quadrupole-Orbitrap (Q-Exactive)...
May 8, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28474046/mechanistic-insight-into-the-heme-independent-interplay-between-iron-and-carbon-monoxide-in-cftr-and-slo1-bkca-channels
#11
REVIEW
Guangyu Wang
Ion channels have been extensively reported as effectors of carbon monoxide (CO). However, the mechanisms of heme-independent CO action are still not known. Because most ion channels are heterologously expressed on human embryonic kidney cells that are cultured in Fe(3+)-containing media, CO may act as a small and strong iron chelator to disrupt a putative iron bridge in ion channels and thus to tune their activity. In this review CFTR and Slo1 BKCa channels are employed to discuss the possible heme-independent interplay between iron and CO...
May 5, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28474044/glutathione-binding-to-dirhodium-tetraacetate-a-spectroscopic-mass-spectral-and-computational-study-of-an-anti-tumour-compound
#12
Daisy L Wong, Angel Zhang, Abayomi S Faponle, Sam P de Visser, Martin J Stillman
Glutathione (γ-l-glutamyl-l-cysteinyl-glycine) is a ubiquitous tripeptide found in all plants and animals. Glutathione has key roles as a metallochaperone and as a cellular thiol involved in metabolism. Little is known about how glutathione interacts with organometallic compounds in vivo. Here, we report the reactions of glutathione in vitro with dirhodium(ii) tetraacetate (tetrakis(μ-acetato)dirhodium(ii), Rh2(OAc)4), a compound with anti-tumour properties. Electrospray ionization mass spectrometry, UV-Visible absorption and circular dichroism spectroscopic methods were used to determine the stoichiometries and optical properties of the final conjugate...
May 5, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28470295/hepcidin-a-real-time-biomarker-of-iron-need
#13
Dominic J Hare
There are numerous blood-based biomarkers for assessing iron stores, but all come with certain limitations. Hepcidin is a hormone primarily produced in the liver that has been proposed as the 'master regulator' of dietary uptake and iron metabolism, and has enormous potential to provide a 'real time' indicator of body iron levels. In this Minireview, the biochemical function of hepcidin in regulating iron levels will be discussed, with a specific focus on how hepcidin can aid in the assessment of iron stores and clinical diagnosis of iron deficiency, iron deficiency anaemia and other iron-related disorders...
May 4, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28466911/stepwise-copper-i-binding-to-metallothionein-a-mixed-cooperative-and-non-cooperative-mechanism-for-all-20-copper-ions
#14
Judith S Scheller, Gordon W Irvine, Daisy L Wong, Andrea Hartwig, Martin J Stillman
Copper is a ubiquitous trace metal of vital importance in that it serves as a cofactor in many metalloenzymes. Excess copper becomes harmful if not sequestered appropriately in the cell. As a metal ion chaperone, metallothionein (MT) has been proposed as a key player in zinc and copper homeostasis within the cell. The underlying mechanisms by which MT sequesters and transfers copper ions, and subsequently achieves its proposed biological function remain unknown. Using a combination of electrospray ionization mass spectrometry (ESI-MS), circular dichroism (CD), and emission spectroscopy, we report that the Cu(i) to human apo-MT1a binding mechanism is highly pH-dependent...
May 3, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28466891/analogues-of-desferrioxamine-b-designed-to-attenuate-iron-mediated-neurodegeneration-synthesis-characterisation-and-activity-in-the-mptp-mouse-model-of-parkinson-s-disease
#15
Michael P Gotsbacher, Thomas J Telfer, Paul K Witting, Kay L Double, David I Finkelstein, Rachel Codd
Parkinson's disease (PD) is a neurodegenerative disorder characterised by the death of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the brain and formation of α-synuclein-containing intracellular inclusions. Excess intraneuronal iron in the SNpc increases reactive oxygen species (ROS), which identifies removing iron as a possible therapeutic strategy. Desferrioxamine B (DFOB, 1) is an iron chelator produced by bacteria. Its high Fe(iii) affinity, water solubility and low chronic toxicity is useful in removing iron accumulated in plasma from patients with transfusion-dependent blood disorders...
May 3, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28447092/the-co-dehydrogenase-accessory-protein-coot-is-a-novel-nickel-binding-protein
#16
J Timm, C Brochier-Armanet, J Perard, B Zambelli, S Ollagnier-de-Choudens, S Ciurli, C Cavazza
In Rhodospirillum rubrum, maturation of Carbon Monoxide Dehydrogenase (CODH) requires three accessory proteins, CooC, CooT and CooJ, dedicated to nickel insertion into the active site, which is constituted by a distorted [NiFe3S4] cubane coordinated with a mononuclear Fe site. CooC is an ATPase proposed to provide the energy required for the maturation process, while CooJ is described as a metallochaperone with 16 histidines and 2 cysteines at the C-terminus, likely involved in metal binding and/or storage...
April 27, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28440833/structure-function-studies-of-acinetobactin-analogs
#17
Justin A Shapiro, Timothy A Wencewicz
Pathogenic Acinetobacter baumannii excrete the siderophore pre-acinetobactin as an iron-scavenging virulence factor. Pre-acinetobactin is a 2,3-dihydroxy-phenyl oxazoline that undergoes pH-dependent isomerization to the isooxazolidinone form acinetobactin in order to expand the pH range for iron acquisition by A. baumannii. In this study we establish important structure-function relationships for the kinetics of isomerization, iron(iii) binding, and siderophore utilization by A. baumannii. We showed that electronic properties of the phenyl oxazoline influence isomerization kinetics and iron(iii) binding...
April 25, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28436510/unique-structural-properties-of-dna-interstrand-cross-links-formed-by-a-new-antitumor-dinuclear-pt-ii-complex
#18
O Hrabina, J Kasparkova, T Suchankova, V Novohradsky, Z Guo, Viktor Brabec
The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH3)2Cl]2(4,4'-methylenedianiline)}(2+) (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3'-3' direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins.
April 24, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28436502/arsenolipids-exert-less-toxicity-in-a-human-neuron-astrocyte-co-culture-as-compared-to-the-respective-monocultures
#19
B Witt, J Bornhorst, H Mitze, F Ebert, S Meyer, K A Francesconi, T Schwerdtle
Arsenic-containing hydrocarbons (AsHCs), natural products found in seafood, have recently been shown to exert toxic effects in human neurons. In this study we assessed the toxicity of three AsHCs in cultured human astrocytes. Due to the high cellular accessibility and substantial toxicity observed astrocytes were identified as further potential brain target cells for arsenolipids. Thereby, the AsHCs exerted a 5-19-fold higher cytotoxicity in astrocytes as compared to arsenite. Next we compared the toxicity of the arsenicals in a co-culture model of the respective human astrocytes and neurons...
April 24, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28425536/cisplatin-resistance-in-cell-models-evaluation-of-metallomic-and-biological-predictive-biomarkers-to-address-early-therapy-failure
#20
Marta Espina, Mario Corte-Rodríguez, Leticia Aguado, María Montes-Bayón, Marta I Sierra, Pablo Martínez-Camblor, Elisa Blanco-González, L María Sierra
Cisplatin, one of the most extensively used metallodrugs in cancer treatment, presents the important drawback of patient resistance. This resistance is the consequence of different processes including those preventing the formation of DNA adducts and/or their quick removal. Thus, a tool for the accurate detection and quantitation of cisplatin-induced adducts might be valuable for predicting patient resistance. To prove the validity of such an assumption, highly sensitive plasma mass spectrometry (ICP-MS) strategies were applied to determine DNA adduct levels and intracellular Pt concentrations...
April 20, 2017: Metallomics: Integrated Biometal Science
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