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Frontiers in Computational Neuroscience

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https://www.readbyqxmd.com/read/29780316/resonance-analysis-as-a-tool-for-characterizing-functional-division-of-layer-5-pyramidal-neurons
#1
Melvin A Felton, Alfred B Yu, David L Boothe, Kelvin S Oie, Piotr J Franaszczuk
Evidence suggests that layer 5 pyramidal neurons can be divided into functional zones with unique afferent connectivity and membrane characteristics that allow for post-synaptic integration of feedforward and feedback inputs. To assess the existence of these zones and their interaction, we characterized the resonance properties of a biophysically-realistic compartmental model of a neocortical layer 5 pyramidal neuron. Consistent with recently published theoretical and empirical findings, our model was configured to have a "hot zone" in distal apical dendrite and apical tuft where both high- and low-threshold Ca2+ ionic conductances had densities 1-2 orders of magnitude higher than anywhere else in the apical dendrite...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29765314/underlying-mechanisms-of-cooperativity-input-specificity-and-associativity-of-long-term-potentiation-through-a-positive-feedback-of-local-protein-synthesis
#2
Lijie Hao, Zhuoqin Yang, Jinzhi Lei
Long-term potentiation (LTP) is a specific form of activity-dependent synaptic plasticity that is a leading mechanism of learning and memory in mammals. The properties of cooperativity, input specificity, and associativity are essential for LTP; however, the underlying mechanisms are unclear. Here, based on experimentally observed phenomena, we introduce a computational model of synaptic plasticity in a pyramidal cell to explore the mechanisms responsible for the cooperativity, input specificity, and associativity of LTP...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29760656/a-fast-contour-detection-model-inspired-by-biological-mechanisms-in-primary-vision-system
#3
Xiaomei Kang, Qingqun Kong, Yi Zeng, Bo Xu
Compared to computer vision systems, the human visual system is more fast and accurate. It is well accepted that V1 neurons can well encode contour information. There are plenty of computational models about contour detection based on the mechanism of the V1 neurons. Multiple-cue inhibition operator is one well-known model, which is based on the mechanism of V1 neurons' non-classical receptive fields. However, this model is time-consuming and noisy. To solve these two problems, we propose an improved model which integrates some additional other mechanisms of the primary vision system...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29740306/topological-schemas-of-memory-spaces
#4
Andrey Babichev, Yuri A Dabaghian
Hippocampal cognitive map-a neuronal representation of the spatial environment-is widely discussed in the computational neuroscience literature for decades. However, more recent studies point out that hippocampus plays a major role in producing yet another cognitive framework-the memory space-that incorporates not only spatial, but also non-spatial memories. Unlike the cognitive maps, the memory spaces, broadly understood as "networks of interconnections among the representations of events," have not yet been studied from a theoretical perspective...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29713271/commentary-evaluation-of-phase-amplitude-coupling-in-resting-state-magnetoencephalographic-signals-effect-of-surrogates-and-evaluation-approach
#5
COMMENT
Esther Florin, Sylvain Baillet
No abstract text is available yet for this article.
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29674961/unsupervised-feature-learning-with-winner-takes-all-based-stdp
#6
Paul Ferré, Franck Mamalet, Simon J Thorpe
We present a novel strategy for unsupervised feature learning in image applications inspired by the Spike-Timing-Dependent-Plasticity (STDP) biological learning rule. We show equivalence between rank order coding Leaky-Integrate-and-Fire neurons and ReLU artificial neurons when applied to non-temporal data. We apply this to images using rank-order coding, which allows us to perform a full network simulation with a single feed-forward pass using GPU hardware. Next we introduce a binary STDP learning rule compatible with training on batches of images...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29674960/emergence-of-relaxation-oscillations-in-neurons-interacting-with-non-stationary-ambient-gaba
#7
Denis A Adamchik, Valery V Matrosov, Victor B Kazantsev
Dynamics of a homogeneous neural population interacting with active extracellular medium were considered. The corresponding mathematical model was tuned specifically to describe the behavior of interneurons with tonic GABA conductance under the action of non-stationary ambient GABA. The feedback provided by the GABA mediated transmembrane current enriched the repertoire of population activity by enabling the oscillatory behavior. This behavior appeared in the form of relaxation oscillations which can be considered as a specific type of brainwaves...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29670518/on-the-physiological-modulation-and-potential-mechanisms-underlying-parieto-occipital-alpha-oscillations
#8
REVIEW
Diego Lozano-Soldevilla
The parieto-occipital alpha (8-13 Hz) rhythm is by far the strongest spectral fingerprint in the human brain. Almost 90 years later, its physiological origin is still far from clear. In this Research Topic I review human pharmacological studies using electroencephalography (EEG) and magnetoencephalography (MEG) that investigated the physiological mechanisms behind posterior alpha. Based on results from classical and recent experimental studies, I find a wide spectrum of drugs that modulate parieto-occipital alpha power...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29670517/computational-models-for-calcium-mediated-astrocyte-functions
#9
REVIEW
Tiina Manninen, Riikka Havela, Marja-Leena Linne
The computational neuroscience field has heavily concentrated on the modeling of neuronal functions, largely ignoring other brain cells, including one type of glial cell, the astrocytes. Despite the short history of modeling astrocytic functions, we were delighted about the hundreds of models developed so far to study the role of astrocytes, most often in calcium dynamics, synchronization, information transfer, and plasticity in vitro , but also in vascular events, hyperexcitability, and homeostasis. Our goal here is to present the state-of-the-art in computational modeling of astrocytes in order to facilitate better understanding of the functions and dynamics of astrocytes in the brain...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29666576/space-by-time-modular-decomposition-effectively-describes-whole-body-muscle-activity-during-upright-reaching-in-various-directions
#10
Pauline M Hilt, Ioannis Delis, Thierry Pozzo, Bastien Berret
The modular control hypothesis suggests that motor commands are built from precoded modules whose specific combined recruitment can allow the performance of virtually any motor task. Despite considerable experimental support, this hypothesis remains tentative as classical findings of reduced dimensionality in muscle activity may also result from other constraints (biomechanical couplings, data averaging or low dimensionality of motor tasks). Here we assessed the effectiveness of modularity in describing muscle activity in a comprehensive experiment comprising 72 distinct point-to-point whole-body movements during which the activity of 30 muscles was recorded...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29643773/using-a-simple-neural-network-to-delineate-some-principles-of-distributed-economic-choice
#11
Pragathi P Balasubramani, Rubén Moreno-Bote, Benjamin Y Hayden
The brain uses a mixture of distributed and modular organization to perform computations and generate appropriate actions. While the principles under which the brain might perform computations using modular systems have been more amenable to modeling, the principles by which the brain might make choices using distributed principles have not been explored. Our goal in this perspective is to delineate some of those distributed principles using a neural network method and use its results as a lens through which to reconsider some previously published neurophysiological data...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29643772/periodic-visual-stimulation-induces-resting-state-brain-network-reconfiguration
#12
Daqing Guo, Fengru Guo, Yangsong Zhang, Fali Li, Yang Xia, Peng Xu, Dezhong Yao
Periodic visual stimulation can evoke the steady-state visual potential (SSVEP) in the brain. Owing to its superior characteristics, the SSVEP has been widely used in neural engineering and cognitive neuroscience studies. However, the underlying mechanisms of the SSVEP are not well understood. In this study, we introduced a brain reconfiguration methodology to explore the possible mechanisms of the SSVEP. The EEG data from five periodic stimuli consistently indicated that the periodic visual stimulation could induce resting-state brain network reconfiguration and that the responses evoked by the stimuli were correlated to the network reconfiguration indexes...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29643771/effective-subnetwork-topology-for-synchronizing-interconnected-networks-of-coupled-phase-oscillators
#13
Hideaki Yamamoto, Shigeru Kubota, Fabio A Shimizu, Ayumi Hirano-Iwata, Michio Niwano
A system consisting of interconnected networks, or a network of networks (NoN), appears diversely in many real-world systems, including the brain. In this study, we consider NoNs consisting of heterogeneous phase oscillators and investigate how the topology of subnetworks affects the global synchrony of the network. The degree of synchrony and the effect of subnetwork topology are evaluated based on the Kuramoto order parameter and the minimum coupling strength necessary for the order parameter to exceed a threshold value, respectively...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29636675/dynamic-information-encoding-with-dynamic-synapses-in-neural-adaptation
#14
Luozheng Li, Yuanyuan Mi, Wenhao Zhang, Da-Hui Wang, Si Wu
Adaptation refers to the general phenomenon that the neural system dynamically adjusts its response property according to the statistics of external inputs. In response to an invariant stimulation, neuronal firing rates first increase dramatically and then decrease gradually to a low level close to the background activity. This prompts a question: during the adaptation, how does the neural system encode the repeated stimulation with attenuated firing rates? It has been suggested that the neural system may employ a dynamical encoding strategy during the adaptation, the information of stimulus is mainly encoded by the strong independent spiking of neurons at the early stage of the adaptation; while the weak but synchronized activity of neurons encodes the stimulus information at the later stage of the adaptation...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29636674/the-importance-of-spatial-visual-scene-parameters-in-predicting-optimal-cone-sensitivities-in-routinely-trichromatic-frugivorous-old-world-primates
#15
Tristan Matthews, Daniel Osorio, Andrea Cavallaro, Lars Chittka
Computational models that predict the spectral sensitivities of primate cone photoreceptors have focussed only on the spectral, not spatial, dimensions. On the ecologically valid task of foraging for fruit, such models predict the M-cone ("green") peak spectral sensitivity 10-20 nm further from the L-cone ("red") sensitivity peak than it is in nature and assume their separation is limited by other visual constraints, such as the requirement of high-acuity spatial vision for closer M and L peak sensitivities...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29632482/closed-loop-deep-brain-stimulation-for-refractory-chronic-pain
#16
Prasad Shirvalkar, Tess L Veuthey, Heather E Dawes, Edward F Chang
Pain is a subjective experience that alerts an individual to actual or potential tissue damage. Through mechanisms that are still unclear, normal physiological pain can lose its adaptive value and evolve into pathological chronic neuropathic pain. Chronic pain is a multifaceted experience that can be understood in terms of somatosensory, affective, and cognitive dimensions, each with associated symptoms and neural signals. While there have been many attempts to treat chronic pain, in this article we will argue that feedback-controlled 'closed-loop' deep brain stimulation (DBS) offers an urgent and promising route for treatment...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29615886/evidence-in-support-of-the-independent-channel-model-describing-the-sensorimotor-control-of-human-stance-using-a-humanoid-robot
#17
Jantsje H Pasma, Lorenz Assländer, Joost van Kordelaar, Digna de Kam, Thomas Mergner, Alfred C Schouten
The Independent Channel (IC) model is a commonly used linear balance control model in the frequency domain to analyze human balance control using system identification and parameter estimation. The IC model is a rudimentary and noise-free description of balance behavior in the frequency domain, where a stable model representation is not guaranteed. In this study, we conducted firstly time-domain simulations with added noise, and secondly robot experiments by implementing the IC model in a real-world robot (PostuRob II) to test the validity and stability of the model in the time domain and for real world situations...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29556186/relating-the-structure-of-noise-correlations-in-macaque-primary-visual-cortex-to-decoder-performance
#18
Or P Mendels, Maoz Shamir
Noise correlations in neuronal responses can have a strong influence on the information available in large populations. In addition, the structure of noise correlations may have a great impact on the utility of different algorithms to extract this information that may depend on the specific algorithm, and hence may affect our understanding of population codes in the brain. Thus, a better understanding of the structure of noise correlations and their interplay with different readout algorithms is required. Here we use eigendecomposition to investigate the structure of noise correlations in populations of about 50-100 simultaneously recorded neurons in the primary visual cortex of anesthetized monkeys, and we relate this structure to the performance of two common decoders: the population vector and the optimal linear estimator...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29551968/self-consistent-scheme-for-spike-train-power-spectra-in-heterogeneous-sparse-networks
#19
Rodrigo F O Pena, Sebastian Vellmer, Davide Bernardi, Antonio C Roque, Benjamin Lindner
Recurrent networks of spiking neurons can be in an asynchronous state characterized by low or absent cross-correlations and spike statistics which resemble those of cortical neurons. Although spatial correlations are negligible in this state, neurons can show pronounced temporal correlations in their spike trains that can be quantified by the autocorrelation function or the spike-train power spectrum. Depending on cellular and network parameters, correlations display diverse patterns (ranging from simple refractory-period effects and stochastic oscillations to slow fluctuations) and it is generally not well-understood how these dependencies come about...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29541024/temporal-dissociation-of-neocortical-and-hippocampal-contributions-to-mental-time-travel-using-intracranial-recordings-in-humans
#20
Roey Schurr, Mor Nitzan, Ruth Eliahou, Laurent Spinelli, Margitta Seeck, Olaf Blanke, Shahar Arzy
In mental time travel (MTT) one is "traveling" back-and-forth in time, remembering, and imagining events. Despite intensive research regarding memory processes in the hippocampus, it was only recently shown that the hippocampus plays an essential role in encoding the temporal order of events remembered, and therefore plays an important role in MTT. Does it also encode the temporal relations of these events to the remembering self? We asked patients undergoing pre-surgical evaluation with depth electrodes penetrating the temporal lobes bilaterally toward the hippocampus to project themselves in time to a past, future, or present time-point, and then make judgments regarding various events...
2018: Frontiers in Computational Neuroscience
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