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Frontiers in Behavioral Neuroscience

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https://www.readbyqxmd.com/read/27932959/exposure-to-ketamine-anesthesia-affects-rat-impulsive-behavior
#1
António Melo, Hugo Leite-Almeida, Clara Ferreira, Nuno Sousa, José M Pêgo
Introduction: Ketamine is a general anesthetic (GA) that activates several neurotransmitter pathways in various part of the brain. The acute effects as GA are the most well-known and sought-after: to induce loss of responsiveness and to produce immobility during invasive procedures. However, there is a concern that repeated exposure might induce behavioral changes that could outlast their acute effect. Most research in this field describes how GA affects cognition and memory. Our work is to access if general anesthesia with ketamine can disrupt the motivational behavior trait, more specifically measuring impulsive behavior...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27917115/switching-adolescent-high-fat-diet-to-adult-control-diet-restores-neurocognitive-alterations
#2
Chloé Boitard, Shauna L Parkes, Amandine Cavaroc, Frédéric Tantot, Nathalie Castanon, Sophie Layé, Sophie Tronel, Gustavo Pacheco-Lopez, Etienne Coutureau, Guillaume Ferreira
In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in adolescents is particularly alarming since this is a period of ongoing maturation for brain structures (including the hippocampus and amygdala) and for the hypothalamic-pituitary-adrenal (HPA) stress axis, which is required for cognitive and emotional processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads to impaired hippocampal function and enhanced amygdala function through HPA axis alteration (Boitard et al...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27917114/differential-responses-of-thalamic-reticular-neurons-to-nociception-in-freely-behaving-mice
#3
Yeowool Huh, Jeiwon Cho
Pain serves an important protective role. However, it can also have debilitating adverse effects if dysfunctional, such as in pathological pain conditions. As part of the thalamocortical circuit, the thalamic reticular nucleus (TRN) has been implicated to have important roles in controlling nociceptive signal transmission. However studies on how TRN neurons, especially how TRN neuronal subtypes categorized by temporal bursting firing patterns-typical bursting, atypical bursting and non-bursting TRN neurons-contribute to nociceptive signal modulation is not known...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27909401/implicit-learning-in-transient-global-amnesia-and-the-role-of-stress
#4
Frauke Nees, Martin Griebe, Anne Ebert, Michaela Ruttorf, Benjamin Gerber, Oliver T Wolf, Lothar R Schad, Achim Gass, Kristina Szabo
Transient global amnesia (TGA) is a disorder with reversible anterograde disturbance of explicit memory, frequently preceded by an emotionally or physically stressful event. By using magnetic resonance imaging (MRI) following an episode of TGA, small hippocampal lesions have been observed. Hence it has been postulated that the disorder is caused by the stress-related transient inhibition of memory formation in the hippocampus. In experimental studies, stress has been shown to affect both explicit and implicit learning-the latter defined as learning and memory processes that lack conscious awareness of the information acquired...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27899885/interacting-cannabinoid-and-opioid-receptors-in-the-nucleus-accumbens-core-control-adolescent-social-play
#5
Antonia Manduca, Olivier Lassalle, Marja Sepers, Patrizia Campolongo, Vincenzo Cuomo, Giovanni Marsicano, Brigitte Kieffer, Louk J M J Vanderschuren, Viviana Trezza, Olivier J J Manzoni
Social play behavior is a highly rewarding, developmentally important form of social interaction in young mammals. However, its neurobiological underpinnings remain incompletely understood. Previous work has suggested that opioid and endocannabinoid neurotransmission interact in the modulation of social play. Therefore, we combined behavioral, pharmacological, electrophysiological, and genetic approaches to elucidate the role of the endocannabinoid 2-arachidonoylglycerol (2-AG) in social play, and how cannabinoid and opioid neurotransmission interact to control social behavior in adolescent rodents...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27895565/challenges-to-the-pair-bond-neural-and-hormonal-effects-of-separation-and-reunion-in-a-monogamous-primate
#6
Katie Hinde, Chelsea Muth, Nicole Maninger, Benjamin J Ragen, Rebecca H Larke, Michael R Jarcho, Sally P Mendoza, William A Mason, Emilio Ferrer, Simon R Cherry, Marina L Fisher-Phelps, Karen L Bales
Social monogamy at its most basic is a group structure in which two adults form a unit and share a territory. However, many socially monogamous pairs display attachment relationships known as pair bonds, in which there is a mutual preference for the partner and distress upon separation. The neural and hormonal basis of this response to separation from the adult pair mate is under-studied. In this project, we examined this response in male titi monkeys (Callicebus cupreus), a socially monogamous New World primate...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27895564/neural-systems-underlying-emotional-and-non-emotional-interference-processing-an-ale-meta-analysis-of-functional-neuroimaging-studies
#7
Min Xu, Guiping Xu, Yang Yang
Understanding how the nature of interference might influence the recruitments of the neural systems is considered as the key to understanding cognitive control. Although, interference processing in the emotional domain has recently attracted great interest, the question of whether there are separable neural patterns for emotional and non-emotional interference processing remains open. Here, we performed an activation likelihood estimation meta-analysis of 78 neuroimaging experiments, and examined common and distinct neural systems for emotional and non-emotional interference processing...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27895563/the-attentional-dependence-of-emotion-cognition-is-variable-with-the-competing-task
#8
Cheng Chen, Kaibin Jin, Yehua Li, Hongmei Yan
The relationship between emotion and attention has fascinated researchers for decades. Many previous studies have used eye-tracking, ERP, MEG, and fMRI to explore this issue but have reached different conclusions: some researchers hold that emotion cognition is an automatic process and independent of attention, while some others believed that emotion cognition is modulated by attentional resources and is a type of controlled processing. The present research aimed to investigate this controversy, and we hypothesized that the attentional dependence of emotion cognition is variable with the competing task...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27881957/the-effects-of-excitatory-and-inhibitory-social-cues-on-cocaine-seeking-behavior
#9
Mark A Smith, Huailin Zhang, Andrea M Robinson
Social partners influence the likelihood of using drugs, developing a substance use disorder and relapse to drug use after a period of abstinence. Preclinical studies report that social cues influence the acquisition of cocaine use, the escalation of cocaine use over time, and the compulsive patterns of cocaine use that emerge during an extended binge. The purpose of this study was to examine the effects of social cues on the reinstatement of cocaine-seeking behavior after a period of abstinence. Male rats were obtained at weaning, assigned to triads (three rats/cage), reared to adulthood and implanted with intravenous catheters...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27881956/ovarian-sex-hormones-modulate-compulsive-affective-and-cognitive-functions-in-a-non-induced-mouse-model-of-obsessive-compulsive-disorder
#10
Swarup Mitra, Cristiane P Bastos, Katherine Bates, Grace S Pereira, Abel Bult-Ito
There is currently a lack of understanding of how surgical menopause can influence obsessions, compulsions and associated affective and cognitive functions in female obsessive-compulsive disorder (OCD) patients. Early menopause in women due to surgical removal of ovaries not only causes dramatic hormonal changes, but also may induce affective and cognitive disorders. Here, we tested if surgical removal of ovaries (ovariectomy, OVX), which mimics surgical menopause in humans, would result in exacerbation of compulsive, affective and cognitive behaviors in mice strains that exhibit a spontaneous compulsive-like phenotype...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27877118/contexts-paired-with-junk-food-impair-goal-directed-behavior-in-rats-implications-for-decision-making-in-obesogenic-environments
#11
Michael D Kendig, Ambrose M K Cheung, Joel S Raymond, Laura H Corbit
The high prevalence of obesity and related metabolic diseases calls for greater understanding of the factors that drive excess energy intake. Calorie-dense palatable foods are readily available and often are paired with highly salient environmental cues. These cues can trigger food-seeking and consumption in the absence of hunger. Here we examined the effects of palatable food-paired environmental cues on control of instrumental food-seeking behavior. In Experiment 1, adult male rats received exposures to one context containing three "junk" foods (JFs context) and another containing chow (Chow context)...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27877117/general-habit-propensity-relates-to-the-sensation-seeking-subdomain-of-impulsivity-but-not-obesity
#12
Anja Dietrich, Sanne de Wit, Annette Horstmann
According to dual-system theory, instrumental learning and performance depend on the balance between goal-directed and habitual action control. Overreliance on habits has been argued to characterize clinical conditions such as drug addiction or obsessive-compulsive disorder as well as obesity and excessive impulsivity. A tendency toward habitual action control in obesity has already been indicated in the food domain. However, impairments might not be restricted to eating behavior. This has been suggested by domain-general obesity-associated disturbances in executive function as well as alterations in corticostriatal circuits underlying the goal-directed and habitual systems...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27872586/loss-of-ensemble-segregation-in-dentate-gyrus-but-not-in-somatosensory-cortex-during-contextual-fear-memory-generalization
#13
Marie Yokoyama, Naoki Matsuo
The details of contextual or episodic memories are lost and generalized with the passage of time. Proper generalization may underlie the formation and assimilation of semantic memories and enable animals to adapt to ever-changing environments, whereas overgeneralization of fear memory evokes maladaptive fear responses to harmless stimuli, which is a symptom of anxiety disorders such as post-traumatic stress disorder (PTSD). To understand the neural basis of fear memory generalization, we investigated the patterns of neuronal ensemble reactivation during memory retrieval when contextual fear memory expression is generalized using transgenic mice that allowed us to visualize specific neuronal ensembles activated during memory encoding and retrieval...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27857685/conditional-knockout-of-cav2-1-disrupts-the-accuracy-of-spatial-recognition-of-ca1-place-cells-and-spatial-contextual-recognition-behavior
#14
Dahee Jung, Yu J Hwang, Hoon Ryu, Masanobu Kano, Kenji Sakimura, Jeiwon Cho
Hippocampal pyramidal neurons play an essential role in processing spatial information as implicated with its place-dependent firing. Although, previous slice physiology studies have reported that voltage gated calcium channels contribute to spike shapes and corresponding firing rate in the hippocampus, the roles of P/Q type calcium channels (Cav2.1) underlying neural activity in behaving mice have not been well-investigated. To determine physiological and behavioral roles of Cav2.1, we conducted place cell recordings in CA1 and hippocampus dependent learning/memory tasks using mice lacking Cav2...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27853424/physical-features-of-visual-images-affect-macaque-monkey-s-preference-for-these-images
#15
Shintaro Funahashi
Animals exhibit different degrees of preference toward various visual stimuli. In addition, it has been shown that strongly preferred stimuli can often act as a reward. The aim of the present study was to determine what features determine the strength of the preference for visual stimuli in order to examine neural mechanisms of preference judgment. We used 50 color photographs obtained from the Flickr Material Database (FMD) as original stimuli. Four macaque monkeys performed a simple choice task, in which two stimuli selected randomly from among the 50 stimuli were simultaneously presented on a monitor and monkeys were required to choose either stimulus by eye movements...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27853423/ethanol-and-caffeine-effects-on-social-interaction-and-recognition-in-mice-involvement-of-adenosine-a2a-and-a1-receptors
#16
Laura López-Cruz, Noemí San-Miguel, Pilar Bayarri, Younis Baqi, Christa E Müller, John D Salamone, Mercé Correa
Ethanol and caffeine are frequently consumed in combination and have opposite effects on the adenosine system: ethanol metabolism leads to an increase in adenosine levels, while caffeine is a non-selective adenosine A1/A2A receptor antagonist. These receptors are highly expressed in striatum and olfactory tubercle, brain areas involved in exploration and social interaction in rodents. Ethanol modulates social interaction processes, but the role of adenosine in social behavior is still poorly understood. The present work was undertaken to study the impact of ethanol, caffeine and their combination on social behavior, and to explore the involvement of A1 and A2A receptors on those actions...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27847472/hypothalamic-astrocytes-respond-to-gastric-mucosal-damage-induced-by-restraint-water-immersion-stress-in-rat
#17
Haiji Sun, Ruisheng Li, Shiguo Xu, Zhen Liu, Xiaoli Ma
Restraint water-immersion stress (RWIS), a compound stress model, includes both psychological and physical stimulation. Studies have shown that neurons in the hypothalamus are involved in RWIS, but the role of astrocytes and the interactions between astrocytes and neurons in RWIS are not clear. Here, we tested our hypothesis that hypothalamus astrocytes are involved in RWIS and interact with neurons to regulate gastric mucosal damage induced by RWIS. The expression of Glial fibrillary acidic protein (GFAP) and c-Fos in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) significantly increased following the RWIS...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27847471/maternal-caloric-restriction-implemented-during-the-preconceptional-and-pregnancy-period-alters-hypothalamic-and-hippocampal-endocannabinoid-levels-at-birth-and-induces-overweight-and-increased-adiposity-at-adulthood-in-male-rat-offspring
#18
María Teresa Ramírez-López, Mariam Vázquez, Laura Bindila, Ermelinda Lomazzo, Clementine Hofmann, Rosarío Noemí Blanco, Francisco Alén, María Antón, Juan Decara, Rocío Arco, Daniel Ouro, Laura Orio, Juan Suárez, Beat Lutz, Raquel Gómez de Heras, Fernando Rodríguez de Fonseca
Exposure to inadequate nutritional conditions in critical windows of development has been associated to disturbances on metabolism and behavior in the offspring later in life. The role of the endocannabinoid system, a known regulator of energy expenditure and adaptive behaviors, in the modulation of these processes is unknown. In the present study, we investigated the impact of exposing rat dams to diet restriction (20% less calories than standard diet) during pre-gestational and gestational periods on: (a) neonatal outcomes; (b) endocannabinoid content in hypothalamus, hippocampus and olfactory bulb at birth; (c) metabolism-related parameters; and (d) behavior in adult male offspring...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27847470/pupil-dynamics-reflect-behavioral-choice-and-learning-in-a-go-nogo-tactile-decision-making-task-in-mice
#19
Christian R Lee, David J Margolis
The eye's pupil undergoes dynamic changes in diameter associated with cognitive effort, motor activity and emotional state, and can be used to index brain state across mammalian species. Recent studies in head-fixed mice have linked arousal-related pupil dynamics with global neural activity as well as the activity of specific neuronal populations. However, it has remained unclear how pupil dynamics in mice report trial-by-trial performance of behavioral tasks, and change on a longer time scale with learning...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27833539/validity-of-quinpirole-sensitization-rat-model-of-ocd-linking-evidence-from-animal-and-clinical-studies
#20
REVIEW
Ales Stuchlik, Dominika Radostová, Hana Hatalova, Karel Vales, Tereza Nekovarova, Jana Koprivova, Jan Svoboda, Jiri Horacek
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with 1-3% prevalence. OCD is characterized by recurrent thoughts (obsessions) and repetitive behaviors (compulsions). The pathophysiology of OCD remains unclear, stressing the importance of pre-clinical studies. The aim of this article is to critically review a proposed animal model of OCD that is characterized by the induction of compulsive checking and behavioral sensitization to the D2/D3 dopamine agonist quinpirole. Changes in this model have been reported at the level of brain structures, neurotransmitter systems and other neurophysiological aspects...
2016: Frontiers in Behavioral Neuroscience
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