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Frontiers in Behavioral Neuroscience

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https://www.readbyqxmd.com/read/30425627/sex-and-feeding-status-differently-affect-natural-reward-seeking-behavior-in-olfactory-bulbectomized-rats
#1
Jana Ruda-Kucerova, Mary Tresa Zanda, Petra Amchova, Walter Fratta, Liana Fattore
Substance abuse and depression are common psychiatric disorders with a high rate of comorbidity. Both conditions affect differently men and women and preclinical research has showed many sex differences in drug addiction and depression. The most common approach for modeling depression-addiction comorbidity is the combination of the intravenous drug self-administration and the olfactory bulbectomy (OBX) models in rats. Such a combination has revealed enhanced drug-taking and drug-seeking behaviors in OBX rats, but no study has investigated so far potential sex differences in operant responding and motivation for natural reinforcers in OBX rats...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30420800/born-to-cry-a-genetic-dissection-of-infant-vocalization
#2
David George Ashbrook, Snigdha Roy, Brittany G Clifford, Tobias Riede, Maria Luisa Scattoni, Detlef H Heck, Lu Lu, Robert W Williams
Infant vocalizations are one of the most fundamental and innate forms of behavior throughout avian and mammalian orders. They have a critical role in motivating parental care and contribute significantly to fitness and reproductive success. Dysregulation of these vocalizations has been reported to predict risk of central nervous system pathologies such as hypoxia, meningitis, or autism spectrum disorder. Here, we have used the expanded BXD family of mice, and a diallel cross between DBA/2J and C57BL/6J parental strains, to begin the process of genetically dissecting the numerous facets of infant vocalizations...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30420799/behavioral-and-neurophysiological-effects-of-transcranial-direct-current-stimulation-tdcs-in-fronto-temporal-dementia
#3
Roberta Ferrucci, Simona Mrakic-Sposta, Simona Gardini, Fabiana Ruggiero, Maurizio Vergari, Francesca Mameli, Andrea Arighi, Marco Spallazzi, Federica Barocco, Giovanni Michelini, Anna Margherita Pietroboni, Laura Ghezzi, Giorgio Giulio Fumagalli, Giordano D'Urso, Paolo Caffarra, Elio Scarpini, Alberto Priori, Sara Marceglia
Fronto-temporal dementia (FTD) is the clinical-diagnostic term that is now preferred to describe patients with a range of progressive dementia syndromes associated with focal atrophy of the frontal and anterior temporal cerebral regions. Currently available FTD medications have been used to control behavioral symptoms, even though they are ineffective in some patients, expensive and may induce adverse effects. Alternative therapeutic approaches are worth pursuing, such as non-invasive brain stimulation with transcranial direct current (tDCS)...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30416437/the-modulating-role-of-sex-and-anabolic-androgenic-steroid-hormones-in-cannabinoid-sensitivity
#4
REVIEW
Dicky Struik, Fabrizio Sanna, Liana Fattore
Cannabis is the most commonly used illicit drug worldwide. Although its use is associated with multiple adverse health effects, including the risk of developing addiction, recreational and medical cannabis use is being increasing legalized. In addition, use of synthetic cannabinoid drugs is gaining considerable popularity and is associated with mass poisonings and occasional deaths. Delineating factors involved in cannabis use and addiction therefore becomes increasingly important. Similarly to other drugs of abuse, the prevalence of cannabis use and addiction differs remarkably between males and females, suggesting that sex plays a role in regulating cannabinoid sensitivity...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30416436/putative-inflammatory-sensitive-mechanisms-underlying-risk-or-resilience-to-social-stress
#5
REVIEW
Julie E Finnell, Susan K Wood
It has been well recognized that exposure to stress can lead to the onset of psychosocial disorders such as depression. While there are a number of antidepressant therapies currently available and despite producing immediate neurochemical alterations, they require weeks of continuous use in order to exhibit antidepressant efficacy. Moreover, up to 30% of patients do not respond to typical antidepressants, suggesting that our understanding of the pathophysiology underlying stress-induced depression is still limited...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30416435/effects-of-cage-enrichment-on-behavior-welfare-and-outcome-variability-in-female-mice
#6
Jeremy D Bailoo, Eimear Murphy, Maria Boada-Saña, Justin A Varholick, Sara Hintze, Caroline Baussière, Kerstin C Hahn, Christine Göpfert, Rupert Palme, Bernhard Voelkl, Hanno Würbel
The manner in which laboratory rodents are housed is driven by economics (minimal use of space and resources), ergonomics (ease of handling and visibility of animals), hygiene, and standardization (reduction of variation). This has resulted in housing conditions that lack sensory and motor stimulation and restrict the expression of species-typical behavior. In mice, such housing conditions have been associated with indicators of impaired welfare, including abnormal repetitive behavior (stereotypies, compulsive behavior), enhanced anxiety and stress reactivity, and thermal stress...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30405372/altered-eye-movement-patterns-during-text-reading-in-obsessive-compulsive-disorder-and-internet-gaming-disorder
#7
Tak Hyung Lee, Minah Kim, Yoo Bin Kwak, Wu Jeong Hwang, Taekwan Kim, Jung-Seok Choi, Jun Soo Kwon
Obsessive-compulsive disorder (OCD) and internet gaming disorder (IGD), which are similar in that both involve repetitive behaviors and related with cognitive dysfunctions, frequently begin in early adolescence, which is a critical period for learning. Although the deterioration in cognitive functioning caused by these conditions may have adverse effects on information processing, such as text reading, there has been no comprehensive research on the objective indicators of altered reading patterns in these patients...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30405371/attention-bias-test-differentiates-anxiety-and-depression-in-sheep
#8
Jessica E Monk, Sue Belson, Ian G Colditz, Caroline Lee
Negative affective states such as anxiety and depression pose a risk to animal welfare, however, practical tests for assessing these states in animals are limited. In humans, anxious individuals are shown to pay more attention toward threatening information than non-anxious individuals, known as an attention bias. Previously, an attention bias test was developed and validated as a measure of anxious states in sheep, where more anxious sheep showed increased attention toward a threat (dog) and were more vigilant than Control animals...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30405370/the-role-of-estrogen-receptor-%C3%AE-er%C3%AE-in-the-establishment-of-hierarchical-social-relationships-in-male-mice
#9
Mariko Nakata, Anders Ågmo, Shoko Sagoshi, Sonoko Ogawa
Acquisition of social dominance is important for social species including mice, for preferential access to foods and mates. Male mice establish social rank through agonistic behaviors, which are regulated by gonadal steroid hormone, testosterone, as its original form and aromatized form. It is well known that estrogen receptors (ERs), particularly ER α (ERα), mediate effects of aromatized testosterone, i.e., 17β-estradiol, but precise role played by ER β (ERβ) is still unclear. In the present study, we investigated effects of ERβ gene disruption on social rank establishment in male mice...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30405369/linalool-odor-induced-anxiolytic-effects-in-mice
#10
Hiroki Harada, Hideki Kashiwadani, Yuichi Kanmura, Tomoyuki Kuwaki
In folk medicine, it has long been believed that odorous compounds derived from plant extracts can have anxiolytic effects. Among them, linalool, one of the terpene alcohols in lavender extracts, has been reported to have the anxiolytic effects. However, the anxiolytic nature of the linalool odor itself as well as its potential action through the olfactory system has not been thoroughly examined. In this study, we examined the anxiolytic effects of linalool odor with light/dark box test and with elevated plus maze (EPM), and found that linalool odor has an anxiolytic effect without motor impairment in mice...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30405368/gentle-handling-attenuates-innate-defensive-responses-to-visual-threats
#11
Xuemei Liu, Chen Chen, Yuanming Liu, Zhijie Wang, Kang Huang, Feng Wang, Liping Wang
Innate defensive responses to threats are essential for animal survival. The complexity and variability of innate defensive behaviors can be due to individual experiences, environmental factors, and internal states. However, it is not completely understood if the gentle handling involved in sensory processing affects innate defensive responses to visual threats. Here, we report attenuation of innate defensive responses after gentle handling accompanied by de-excitation of the intermediate layer (IL) and deep layer (DL) of the superior colliculus (SC) but not of the superficial layer (SL)...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30386220/validating-rat-model-of-empathy-for-pain-effects-of-pain-expressions-in-social-partners
#12
Chun-Li Li, Yang Yu, Ting He, Rui-Rui Wang, Kai-Wen Geng, Rui Du, Wen-Jun Luo, Na Wei, Xiao-Liang Wang, Yang Wang, Yan Yang, Yao-Qing Yu, Jun Chen
Pain can be socially transferred between familiar rats due to empathic responses. To validate rat model of empathy for pain, effects of pain expressions in a cagemate demonstrator (CD) in pain on empathic pain responses in a naïve cagemate observer (CO) after 30 min priming dyadic social interactions (PDSI) were evaluated. The CD rats were prepared with four pain models: bee venom (BV), formalin, complete Freund's adjuvant (CFA), and spared nerve injury (SNI). Both BV and formalin tests are characterized by displayable and eye-identifiable spontaneous pain-related behaviors (SPRB) immediately after treatment, while CFA and SNI models are characterized by delayed occurrence of evoked pain hypersensitivity but with less eye-identifiable SPRB...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30369873/human-vicarious-trial-and-error-is-predictive-of-spatial-navigation-performance
#13
Diogo Santos-Pata, Paul F M J Verschure
When learning new environments, rats often pause at decision points and look back and forth over their possible trajectories as if they were imagining the future outcome of their actions, a behavior termed "Vicarious trial and error" (VTE). As the animal learns the environmental configuration, rats change from deliberative to habitual behavior, and VTE tends to disappear, suggesting a functional relevance in the early stages of learning. Despite the extensive research on spatial navigation, learning and VTE in the rat model, fewer studies have focused on humans...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30356904/nesting-environment-provides-sex-specific-neuroprotection-in-a-rat-model-of-neonatal-hypoxic-ischemic-injury
#14
Briana Mason, L G Rollins, Evans Asumadu, Christina Cange, Najah Walton, S Tiffany Donaldson
Hypoxic-ischemic (HI) encephalopathy is a devastating injury that occurs when the fetal brain is deprived of oxygen and blood to a degree that may lead to neurological damage, seizing and cerebral palsy. In rodents, early environmental enrichment that promotes maternal care-taking behavior (mCTB) can improve neurobehavioral outcomes and protect against neurological decline. We hypothesized that an enhanced nesting environment would improve mCTB as measured by pup weight gain, and support greater HI recovery in developing rats...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30356891/enriched-environment-facilitates-anxiolytic-efficacy-driven-by-deep-brain-stimulation-of-medial-prefrontal-cortex
#15
Yamini Bhaskar, Lee Wei Lim, Rupshi Mitra
Deep brain stimulation (DBS) is a widely used treatment for neurodegenerative disorders like Parkinson's disease. Recently, several studies have used preclinical animal models to suggest that DBS has a potential to improve emotional symptoms in mental disorders such as treatment-resistant depression and post-traumatic stress disorder. An important difference between neurodegenerative and emotional disorders is the crucial role of environment in the ontogeny of the latter. Thus, it is important to understand the effects of DBS in the context of environmental variation...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30356849/inhibiting-rip1-improves-chronic-stress-induced-cognitive-impairments-in-d-galactose-induced-aging-mice
#16
Wenxiang Qing, Fan Li, Xueqin Wang, Chengxuan Quan, Wen Ouyang, Qin Liao
Mounting evidence shows that chronic stress can affect both the structure and function of the brain resulting in decreased synaptic plasticity and cognitive dysfunction. Although several studies have indicated that aged brains are more vulnerable to chronic stress, it remains unknown how to prevent stress-induced memory deficits in aged animals. Neuroinflammation plays an important role in the pathogenesis of chronic stress-related brain dysfunction. Receptor-interacting protein 1 (RIP1) is a key molecule that can modulate inflammation, apoptosis, and necroptosis...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30356831/cocaine-paired-environment-increases-satb2-levels-in-the-rat-paraventricular-thalamus
#17
Ahmad Salti, Galina Apostolova, Kai K Kummer, Cristina Lemos, Georg Dechant, Rana El Rawas
SATB2 is a DNA binding protein that specifically binds the nuclear matrix attachment region and functions as a regulator of the transcription of large chromatin domains. Unlike its well addressed role during brain development, the role of SATB2 in adult brain is under-investigated. It has been shown that deletion of SATB2 from the forebrain of adult mice significantly impaired long-term memory for contextual fear and object recognition memory. The aim of the present study was to investigate the effects of appetitive stimuli such as cocaine and social interaction (SI) on SATB2 expression in the adult rat brain...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30356828/medial-habenula-interpeduncular-nucleus-circuit-contributes-to-anhedonia-like-behavior-in-a-rat-model-of-depression
#18
Chunpeng Xu, Yanfei Sun, Xuewei Cai, Tingting You, Hongzhe Zhao, Yang Li, Hua Zhao
The habenula is a nuclear complex composed of the lateral habenula (LHb) and medial habenula (MHb), two distinct structures. Much progress has been made to emphasize the role of the LHb in the pathogenesis of depression. In contrast, relatively less research has focused on the MHb. However, in recent years, the role of the MHb has begun to gain increasing attention. The MHb connects to the interpeduncular nucleus (IPN) both morphologically and functionally. The MHb-IPN pathway plays an important role in regulating higher brain functions, including cognition, reward, and decision making...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30356718/effect-of-ketamine-on-ltp-and-nmdar-epsc-in-hippocampus-of-the-chronic-social-defeat-stress-mice-model-of-depression
#19
Yu Yang, Weina Ju, Haining Zhang, Li Sun
Depression is a common mental disorder that is associated with memory dysfunction. Ketamine has recently been demonstrated to be a rapid antidepressant. The mechanisms underlying how depression induces memory dysfunction and how ketamine relieves depressive symptoms remain poorly understood. This work compared three groups of male C57BL/6J mice: mice exposed to chronic social defeat stress (CSDS) to induce a depression-like phenotype, depression-like mice treated with ketamine, and control mice that were not exposed to CSDS or treated with ketamine...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30356704/sex-dependent-effects-of-environmental-enrichment-on-spatial-memory-and-brain-derived-neurotrophic-factor-bdnf-signaling-in-a-developmental-two-hit-mouse-model-combining-bdnf-haploinsufficiency-and-chronic-glucocorticoid-stimulation
#20
Adrienne M Grech, Udani Ratnayake, Anthony J Hannan, Maarten van den Buuse, Rachel A Hill
Neurodevelopmental disorders are thought to be caused by a combination of adverse genetic and environmental insults. The "two-hit" hypothesis suggests that an early first "hit" primes the developing brain to be vulnerable to a second "hit" during adolescence which triggers behavioral dysfunction. We have previously modeled this scenario in mice and found that the combined effect of a genetic hapolinsuffuciency in the brain-derived neurotrophic factor (BDNF) gene (1st hit) and chronic corticosterone (CORT) treatment during adolescence (2nd hit), caused spatial memory impairments in adulthood...
2018: Frontiers in Behavioral Neuroscience
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