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Frontiers in Behavioral Neuroscience

Juan Carlos Martínez-Lazcano, Alfredo López-Quiroz, Rocío Alcantar-Almaraz, Sergio Montes, Alicia Sánchez-Mendoza, Mireya Alcaraz-Zubeldia, Luis Antonio Tristán-López, Beatriz Eugenia Sánchez-Hernández, Adriana Morales-Martínez, Camilo Ríos, Francisca Pérez-Severiano
The effects caused by exposure to lead (Pb) are still considered as a relevant health risk despite public policies aimed to restricting the use of this element. The toxicity limit in the blood (10 μg/dL, established by the Center for Disease Control and Prevention) has been insufficient to prevent adverse effects and even lower values have been related to neurobehavioral dysfunctions in children. Currently, there is not a safe limit of exposure to Pb. A large body of evidence points to environmental pollutant exposure as the cause of predisposition to violent behavior, among others...
2018: Frontiers in Behavioral Neuroscience
Olga O Kozanian, David J Rohac, Niusha Bavadian, Alex Corches, Edward Korzus, Kelly J Huffman
Prenatal ethanol exposure (PrEE) produces developmental abnormalities in brain and behavior that often persist into adulthood. We have previously reported abnormal cortical gene expression, disorganized neural circuitry along with deficits in sensorimotor function and anxiety in our CD-1 murine model of fetal alcohol spectrum disorders, or FASD (El Shawa et al., 2013; Abbott et al., 2016). We have proposed that these phenotypes may underlie learning, memory, and behavioral deficits in humans with FASD. Here, we evaluate the impact of PrEE on fear memory learning, recall and amygdala development at two adult timepoints...
2018: Frontiers in Behavioral Neuroscience
Samantha Meneely, Mai-Lynne Dinkins, Miki Kassai, Shangru Lyu, Yuning Liu, Chien-Te Lin, Kori Brewer, Yuqing Li, Stefan Clemens
Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 receptor subtype, however there is no clinical evidence of a D3 receptor dysfunction in RLS patients. In contrast, genome-wide association studies in RLS patients have established that a mutation of the MEIS1 gene is associated with an increased risk in developing RLS, but the effect of MEIS1 dysfunction on sensorimotor function remain unknown. Mouse models for a dysfunctional D3 receptor (D3KO) and Meis1 (Meis1KO) were developed independently, and each animal expresses some features associated with RLS in the clinic, but they have not been compared in their responsiveness to treatment options used in the clinic...
2018: Frontiers in Behavioral Neuroscience
Steven Neal, Molly Kent, Massimo Bardi, Kelly G Lambert
Both social and physical stimuli contribute to the complexity of an animal's environment, influencing biobehavioral responses to subsequent challenges. In the current study, male Long-Evans rats were randomly assigned to an isolate (ISO), social control (SC) or social enriched (SE) group ( n = 8 per group). The SC and SE conditions were group housed with the SE group exposed to physical enrichment stimuli that were natural as opposed to manufactured (e.g., hollowed out log instead of plastic hiding place). On three occasions during their 40-day enriched environment exposure, night/dark phase videos were obtained for 1 h during the early part of the dark phase...
2018: Frontiers in Behavioral Neuroscience
Jasmine I Caulfield, Michael J Caruso, Rebecca A Bourne, Nicole R Chirichella, Laura C Klein, Timothy Craig, Robert H Bonneau, Avery August, Sonia A Cavigelli
In developing youth, allergic asthma is the most common chronic condition, with 9%-10% of youth affected. Asthma onset during childhood and adolescence is further associated with other health issues, particularly psychiatric conditions. To understand causal mechanisms by which developmental asthma may lead to altered behavior, brain and health trajectories, we developed a mouse model of developmental allergic asthma. In the current study, we tested for potential long-term effects of developmental asthma on adult lung function and behavior and brain gene expression associated with emotion and stress regulation...
2018: Frontiers in Behavioral Neuroscience
Kenzo Yamamoto, Katsiaryna V Gris, Jesús E Sotelo Fonseca, Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Daphné Houle-Martel, Theodore Cloutier, Pavel Gris, Denis Gris
Using automated supervised behavioral assessment software, we recorded and analyzed 24 h non-interrupted recordings of mice for a duration of 11 days. With the assistance of free R programming, we used correlation matrix-based hierarchical clustering and factor analysis to separate the 33 activities into meaningful clusters and groups without losing the exhaustive nature of the findings. These groups represent novel meaningful behavioral patterns exhibited by mice in home cage. Thirty-three activities were separated into 5 clusters based on dissimilarity between activities and 6 factors based on statistical modeling...
2018: Frontiers in Behavioral Neuroscience
Megan Oaten, Richard J Stevenson, Mark A Williams, Anina N Rich, Marina Butko, Trevor I Case
Disgust is a natural defensive emotion that has evolved to protect against potential sources of contamination and has been recently linked to moral judgements in many studies. However, that people often report feelings of disgust when thinking about feces or moral transgressions alike does not necessarily mean that the same mechanisms mediate these reactions. The present study used functional magnetic resonance imaging ( n = 22) to investigate whether core and moral disgusts entrain common neural systems. We provide evidence that: (i) activation of overlapping brain regions between core and moral disgust is the result of content overlap in the vignettes- core disgust elicitors -across conditions, and not from moral violations per se , and (ii) moral residue (i...
2018: Frontiers in Behavioral Neuroscience
Olga L Lopatina, Yulia K Komleva, Yana V Gorina, Haruhiro Higashida, Alla B Salmina
Face recognition is an important index in the formation of social cognition and neurodevelopment in humans. Changes in face perception and memory are connected with altered sociability, which is a symptom of numerous brain conditions including autism spectrum disorder (ASD). Various brain regions and neuropeptides are implicated in face processing. The neuropeptide oxytocin (OT) plays an important role in various social behaviors, including face and emotion recognition. Nasal OT administration is a promising new therapy that can address social cognition deficits in individuals with ASD...
2018: Frontiers in Behavioral Neuroscience
Stefanie Neupert, Manuel Hornung, Jocelyn Grenwille Millar, Christoph Johannes Kleineidam
Colony coherence is essential for eusocial insects because it supports the inclusive fitness of colony members. Ants quickly and reliably recognize who belongs to the colony (nestmates) and who is an outsider (non-nestmates) based on chemical recognition cues (cuticular hydrocarbons: CHCs) which as a whole constitute a chemical label. The process of nestmate recognition often is described as matching a neural template with the label. In this study, we tested the prevailing view that ants use commonalities in the colony odor that are present in the CHC profile of all individuals of a colony or whether different CHC profiles are learned independently...
2018: Frontiers in Behavioral Neuroscience
Bruno Lobao-Soares, Paulianny Eduardo-da-Silva, Hugo Amarilha, Jaquelinne Pinheiro-da-Silva, Priscila F Silva, Ana Carolina Luchiari
Ayahuasca is a psychoactive brew traditionally used in shamanistic and vegetalistic rituals and has recently received lot of attention due to potential cognitive benefits. Ayahuasca effects are caused by the synergistic interaction of β-carbolines (harmine, harmaline and tetrahydroarmine) contained in Banisteriopsis caapi stalks combined with the N,N-dimethyltryptamine (DMT) from Psychotria viridis leaves, a potent agonist to serotonin (5-HT) receptors. The present study approaches the effects of chronic and acute exposure to two Ayahuasca concentrations (0...
2018: Frontiers in Behavioral Neuroscience
Alberto Maria Cattaneo
Cydia pomonella (Lepidoptera: Tortricidae) is a major pest of apple, pear and walnuts. For its control, alternative strategies targeting the olfactory system, like mating disruption, have been combined with insecticide applications. The efficacy of these strategies headed the direction of efforts for the functional characterization of codling moth chemosensory receptors to implement further control methods based on chemical sensing. With the advent of transcriptomic analysis, partial and full-length coding sequences of chemosensory receptors have been identified in antennal transcriptomes of C...
2018: Frontiers in Behavioral Neuroscience
Jun Tian, Yaping Yan, Wang Xi, Rui Zhou, Huifang Lou, Shumin Duan, Jiang Fan Chen, Baorong Zhang
The globus pallidus (GP) is emerging as a critical locus of basal ganglia control of motor activity, but the exact role of GABAergic GP neurons remain to be defined. By targeted expression of channelrhodopsin 2 (ChR2) in GABAergic neurons using the VGAT-ChR2-EYFP transgenic mice, we showed that optogenetic stimulation of GABAergic neurons in the right GP produced hyperkinesia. Optogenetic stimulation of GABAergic GP neurons increased c-Fos-positive cells in GP, M1 cortex, and caudate-putamen (CPu), and decreased c-Fos-positive cells in entopeduncular nucleus (EPN), compared to the contralateral hemisphere...
2018: Frontiers in Behavioral Neuroscience
Nicola Dibben, Eduardo Coutinho, José A Vilar, Graciela Estévez-Pérez
Comparison of emotion perception in music and prosody has the potential to contribute to an understanding of their speculated shared evolutionary origin. Previous research suggests shared sensitivity to and processing of music and speech, but less is known about how emotion perception in the auditory domain might be influenced by individual differences. Personality, emotional intelligence, gender, musical training and age exert some influence on discrete, summative judgments of perceived emotion in music and speech stimuli...
2018: Frontiers in Behavioral Neuroscience
Christine N Yohn, Amanda B Leithead, Julian Ford, Alexander Gill, Elizabeth A Becker
Natural variations in parenting are associated with differences in expression of several hormones and neuropeptides which may mediate lasting effects on offspring development, like regulation of stress reactivity and social behavior. Using the bi-parental California mouse, we have demonstrated that parenting and aggression are programmed, at least in part, by paternal behavior as adult offspring model the degree of parental behavior received in development and are more territorial following high as compared to low levels of care...
2018: Frontiers in Behavioral Neuroscience
Levente Szalardy, Mate F Molnar, Denes Zadori, Edina K Cseh, Gabor Veres, Gabor G Kovacs, Laszlo Vecsei, Peter Klivenyi
Dysfunction of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α) has been linked to various neurodegenerative and neuropsychiatric disorders; however, reports on psychic behavioral alterations on PGC-1α-deficient animals are sparse. The present study revisited prior observations of anxiety-related, depression-related, and hippocampal memory-related observations having been made on different PGC-1α-deficient murine strains, in a large-scale analysis on whole-body full-length (FL-)PGC-1α-deficient mice...
2018: Frontiers in Behavioral Neuroscience
Valerie Lee Tryon, Sheri J Y Mizumori
The periaqueductal gray (PAG) has a well-established role in pain processing, autonomic function and behavioral responses to fear. Anatomical work suggests the PAG may mediate food intake and reward processing as it has extensive reciprocal connections within brain circuits that mediate appetitive processes and consummatory behaviors such as prefrontal cortex, hypothalamus, amygdala, parabrachial nucleus (PBN) and ventral tegmental area (Kelley et al., 2005). Therefore, we investigated if the PAG of hungry rats has a functional role in appetitive and consummatory behaviors...
2018: Frontiers in Behavioral Neuroscience
Virginie Lam, Ryusuke Takechi, Matthew A Albrecht, Zachary John D'Alonzo, Liam Graneri, Mark J Hackett, Stephanie Coulson, Nicholas Fimognari, Michael Nesbit, John C L Mamo
Morris water maze (MWM) is widely used to assess cognitive deficits in pre-clinical rodent models. Latency time to reach escape platform is frequently reported, but may be confounded by deficits in visual acuity, or differences in locomotor activity. This study compared performance of Senescence Accelerated Mouse Prone-Strain 8 (SAMP8) and control Senescence Accelerated Mouse Resistant-Strain 1 (SAMR1) mice in classical MWM, relative to performance in a newly developed olfactory-visual maze testing protocol...
2018: Frontiers in Behavioral Neuroscience
Nora Behler, Bianka Leitner, Eva Mezger, Elif Weidinger, Richard Musil, Bernhard Blum, Beatrice Kirsch, Linda Wulf, Lisa Löhrs, Christine Winter, Frank Padberg, Ulrich Palm
Introduction : Current pathophysiological hypotheses of Gilles de la Tourette Syndrome (GTS) refer to temporally abnormal neuronal activation in cortico-striato-thalamo-cortical (CSTC) networks. Modifying cortical activity by non-invasive brain-stimulation appears to be a new treatment option in GTS. Background : Previous studies suggested therapeutic effects of cathodal transcranial direct current stimulation (tDCS) to pre-supplementary motor areas (SMA), however, treatment modalities concerning electrode placement, current intensity and stimulation-rate have not been systematically explored...
2018: Frontiers in Behavioral Neuroscience
Ashna Shome, Razia Sultana, Alina Siddiqui, Russell D Romeo
Adolescent development is marked by significant changes in neurobiological structure and function. One such change is the substantial adolescent-related decline in cellular proliferation and neurogenesis in the dentate gyrus of the hippocampal formation. Though the behavioral implications of these developmental shifts in cell proliferation are unclear, these changes might contribute to the altered cognitive and emotional functions associated with puberty and adolescence. The significant decrease in cellular proliferation throughout adolescence might make the hippocampus more vulnerable to perturbations during this developmental stage, particularly to factors known to disrupt neurogenesis, such as chronic exposure to stress-related hormones...
2018: Frontiers in Behavioral Neuroscience
Catherine Audrin, Tobias Brosch, David Sander, Julien Chanal
Visual attention is an important condition for consumer decision-making. However, not much is known on individuals' determinants of this visual attention. Using eye tracking, this study investigated how psychological values (i.e., materialism) modulate visual attention to specific sources of information (i.e., product, brand and additional information) in the context of luxury consumption. Participants were asked to perform a forced-choice experiment, where products were randomly assigned with luxury and non-luxury brands (Experiment 1) and product information (Experiment 2)...
2018: Frontiers in Behavioral Neuroscience
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