journal
MENU ▼
Read by QxMD icon Read
search

Frontiers in Systems Neuroscience

journal
https://www.readbyqxmd.com/read/28713251/age-related-changes-in-lateral-entorhinal-and-ca3-neuron-allocation-predict-poor-performance-on-object-discrimination
#1
Andrew P Maurer, Sarah A Johnson, Abbi R Hernandez, Jordan Reasor, Daniela M Cossio, Kaeli E Fertal, Jack M Mizell, Katelyn N Lubke, Benjamin J Clark, Sara N Burke
Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28713250/impaired-in-vivo-gamma-oscillations-in-the-medial-entorhinal-cortex-of-knock-in-alzheimer-model
#2
Tomoaki Nakazono, Travis N Lam, Ayushi Y Patel, Masashi Kitazawa, Takashi Saito, Takaomi C Saido, Kei M Igarashi
The entorhinal cortex (EC) has bidirectional connections with the hippocampus and plays a critical role in memory formation and retrieval. EC is one of the most vulnerable regions in the brain in early stages of Alzheimer's disease (AD), a neurodegenerative disease with progressive memory impairments. Accumulating evidence from healthy behaving animals indicates gamma oscillations (30-100 Hz) as critical for mediating interactions in the circuit between EC and hippocampus. However, it is still unclear whether gamma oscillations have causal relationship with memory impairment in AD...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28701931/architecture-of-the-entorhinal-cortex-a-review-of-entorhinal-anatomy-in-rodents-with-some-comparative-notes
#3
REVIEW
Menno P Witter, Thanh P Doan, Bente Jacobsen, Eirik S Nilssen, Shinya Ohara
The entorhinal cortex (EC) is the major input and output structure of the hippocampal formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes including two or many more subdivisions have been proposed, but here we will argue that subdividing EC into two components, the lateral EC (LEC) and medial EC (MEC) might suffice to describe the functional architecture of EC. This subdivision then leads to an anatomical interpretation of the different phenotypes of LEC and MEC. First, we will briefly summarize the cytoarchitectonic differences and differences in hippocampal projection patterns on which the subdivision between LEC and MEC traditionally is based and provide a short comparative perspective...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28701930/biogenic-amines-in-insect-antennae
#4
REVIEW
Marianna I Zhukovskaya, Andrey D Polyanovsky
Insect antenna is a multisensory organ, each modality of which can be modulated by biogenic amines. Octopamine (OA) and its metabolic precursor tyramine (TA) affect activity of antennal olfactory receptor neurons. There is some evidence that dopamine (DA) modulates gustatory neurons. Serotonin can serve as a neurotransmitter in some afferent mechanosensory neurons and both as a neurotransmitter and neurohormone in efferent fibers targeted at the antennal vessel and mechanosensory organs. As a neurohormone, serotonin affects the generation of the transepithelial potential by sensillar accessory cells...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28690501/cortical-activation-during-landmark-centered-vs-gaze-centered-memory-of-saccade-targets-in-the-human-an-fmri-study
#5
Ying Chen, J D Crawford
A remembered saccade target could be encoded in egocentric coordinates such as gaze-centered, or relative to some external allocentric landmark that is independent of the target or gaze (landmark-centered). In comparison to egocentric mechanisms, very little is known about such a landmark-centered representation. Here, we used an event-related fMRI design to identify brain areas supporting these two types of spatial coding (i.e., landmark-centered vs. gaze-centered) for target memory during the Delay phase where only target location, not saccade direction, was specified...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28663726/neural-cross-frequency-coupling-functions
#6
Tomislav Stankovski, Valentina Ticcinelli, Peter V E McClintock, Aneta Stefanovska
Although neural interactions are usually characterized only by their coupling strength and directionality, there is often a need to go beyond this by establishing the functional mechanisms of the interaction. We introduce the use of dynamical Bayesian inference for estimation of the coupling functions of neural oscillations in the presence of noise. By grouping the partial functional contributions, the coupling is decomposed into its functional components and its most important characteristics-strength and form-are quantified...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28659770/evaluation-of-azd1446-as-a-therapeutic-in-dyt1-dystonia
#7
Chelsea N Zimmerman, Karen L Eskow Jaunarajs, Maria Meringolo, Francesca R Rizzo, Massimo Santoro, David G Standaert, Antonio Pisani
DYT1 dystonia is an early-onset, hyperkinetic movement disorder caused by a deletion in the gene TOR1A, which encodes the protein torsinA. Several lines of evidence show that in animal models of DTY1 dystonia, there is impaired basal dopamine (DA) release and enhanced acetylcholine tone. Clinically, anticholinergic drugs are the most effective pharmacological treatment for DYT1 dystonia, but the currently used agents are non-selective muscarinic antagonists and associated with side effects. We used a DYT1 ∆GAG knock-in mouse model (DYT1 KI) to investigate whether nicotine and/or a non-desensitizing nicotinic agonist, AZD1446, would increase DA output in DYT1 dystonia...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28659769/propofol-sevoflurane-and-ketamine-induce-a-reversible-increase-in-delta-gamma-and-theta-gamma-phase-amplitude-coupling-in-frontal-cortex-of-rat
#8
Dinesh Pal, Brian H Silverstein, Lana Sharba, Duan Li, Viviane S Hambrecht-Wiedbusch, Anthony G Hudetz, George A Mashour
Studies from human and non-human species have demonstrated a breakdown of functional corticocortical connectivity during general anesthesia induced by anesthetics with diverse molecular, neurophysiological, and pharmacological profiles. Recent studies have demonstrated that changes in long-range neural communication, and by corollary, functional connectivity, might be influenced by cross-frequency coupling (CFC) between the phase of slow oscillations and the amplitude of local fast oscillations. Phase-amplitude coupling (PAC) between slow oscillations and alpha rhythm during general anesthesia reveal distinct patterns depending on the anesthetic...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28659768/neuroelectric-tuning-of-cortical-oscillations-by-apical-dendrites-in-loop-circuits
#9
David LaBerge, Ray S Kasevich
Bundles of relatively long apical dendrites dominate the neurons that make up the thickness of the cerebral cortex. It is proposed that a major function of the apical dendrite is to produce sustained oscillations at a specific frequency that can serve as a common timing unit for the processing of information in circuits connected to that apical dendrite. Many layer 5 and 6 pyramidal neurons are connected to thalamic neurons in loop circuits. A model of the apical dendrites of these pyramidal neurons has been used to simulate the electric activity of the apical dendrite...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28642689/integrating-neural-circuits-controlling-female-sexual-behavior
#10
REVIEW
Paul E Micevych, Robert L Meisel
The hypothalamus is most often associated with innate behaviors such as is hunger, thirst and sex. While the expression of these behaviors important for survival of the individual or the species is nested within the hypothalamus, the desire (i.e., motivation) for them is centered within the mesolimbic reward circuitry. In this review, we will use female sexual behavior as a model to examine the interaction of these circuits. We will examine the evidence for a hypothalamic circuit that regulates consummatory aspects of reproductive behavior, i...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28620284/electrophysiological-measurements-of-peripheral-vestibular-function-a-review-of-electrovestibulography
#11
REVIEW
Daniel J Brown, Christopher J Pastras, Ian S Curthoys
Electrocochleography (EcochG), incorporating the Cochlear Microphonic (CM), the Summating Potential (SP), and the cochlear Compound Action Potential (CAP), has been used to study cochlear function in humans and experimental animals since the 1930s, providing a simple objective tool to assess both hair cell (HC) and nerve sensitivity. The vestibular equivalent of ECochG, termed here Electrovestibulography (EVestG), incorporates responses of the vestibular HCs and nerve. Few research groups have utilized EVestG to study vestibular function...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28611603/inactivation-of-the-lateral-entorhinal-area-increases-the-influence-of-visual-cues-on-hippocampal-place-cell-activity
#12
Kristin M Scaplen, Rohan N Ramesh, Negin Nadvar, Omar J Ahmed, Rebecca D Burwell
The hippocampus is important for both navigation and associative learning. We previously showed that the hippocampus processes two-dimensional (2D) landmarks and objects differently. Our findings suggested that landmarks are more likely to be used for orientation and navigation, whereas objects are more likely to be used for associative learning. The process by which cues are recognized as relevant for navigation or associative learning, however, is an open question. Presumably both spatial and nonspatial information are necessary for classifying cues as landmarks or objects...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28611602/brain-mechanisms-during-course-of-anesthesia-what-we-know-from-eeg-changes-during-induction-and-recovery
#13
Satoshi Hagihira
No abstract text is available yet for this article.
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28611601/lack-of-responsiveness-during-the-onset-and-offset-of-sevoflurane-anesthesia-is-associated-with-decreased-awake-alpha-oscillation-power
#14
Kara J Pavone, Lijuan Su, Lei Gao, Ersne Eromo, Rafael Vazquez, James Rhee, Lauren E Hobbs, Reine Ibala, Gizem Demircioglu, Patrick L Purdon, Emery N Brown, Oluwaseun Akeju
Anesthetic drugs are typically administered to induce altered states of arousal that range from sedation to general anesthesia (GA). Systems neuroscience studies are currently being used to investigate the neural circuit mechanisms of anesthesia-induced altered arousal states. These studies suggest that by disrupting the oscillatory dynamics that are associated with arousal states, anesthesia-induced oscillations are a putative mechanism through which anesthetic drugs produce altered states of arousal. However, an empirical clinical observation is that even at relatively stable anesthetic doses, patients are sometimes intermittently responsive to verbal commands during states of light sedation...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28611600/changes-in-alpha-frequency-and-power-of-the-electroencephalogram-during-volatile-based-general-anesthesia
#15
Darren Hight, Logan J Voss, Paul S Garcia, Jamie Sleigh
Oscillations in the electroencephalogram (EEG) at the alpha frequency (8-12 Hz) are thought to be ubiquitous during surgical anesthesia, but the details of how this oscillation responds to ongoing changes in volatile anesthetic concentration have not been well characterized. It is not known how often alpha oscillations are absent in the clinical context, how sensitively alpha frequency and power respond to changes in anesthetic concentration, and what effect increased age has on alpha frequency. Bipolar EEG was recorded frontally from 305 patients undergoing surgery with sevoflurane or desflurane providing general anesthesia...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28611599/the-melanin-concentrating-hormone-as-an-integrative-peptide-driving-motivated-behaviors
#16
REVIEW
Giovanne B Diniz, Jackson C Bittencourt
The melanin-concentrating hormone (MCH) is an important peptide implicated in the control of motivated behaviors. History, however, made this peptide first known for its participation in the control of skin pigmentation, from which its name derives. In addition to this peripheral role, MCH is strongly implicated in motivated behaviors, such as feeding, drinking, mating and, more recently, maternal behavior. It is suggested that MCH acts as an integrative peptide, converging sensory information and contributing to a general arousal of the organism...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28588457/sensitivity-to-an-illusion-of-sound-location-in-human-auditory-cortex
#17
Nathan C Higgins, Susan A McLaughlin, Sandra Da Costa, G Christopher Stecker
Human listeners place greater weight on the beginning of a sound compared to the middle or end when determining sound location, creating an auditory illusion known as the Franssen effect. Here, we exploited that effect to test whether human auditory cortex (AC) represents the physical vs. perceived spatial features of a sound. We used functional magnetic resonance imaging (fMRI) to measure AC responses to sounds that varied in perceived location due to interaural level differences (ILD) applied to sound onsets or to the full sound duration...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28579948/modulation-of-low-voltage-activated-inward-current-permeable-to-sodium-and-calcium-by-darpp-32-drives-spontaneous-firing-of-insect-octopaminergic-neurosecretory-cells
#18
Bruno Lapied, Antoine Defaix, Maria Stankiewicz, Eléonore Moreau, Valérie Raymond
Identification of the different intracellular pathways that control phosphorylation/dephosphorylation process of ionic channels represents an exciting alternative approach for studying the ionic mechanisms underlying neuronal pacemaker activity. In the central nervous system of the cockroach Periplaneta americana, octopaminergic neurons, called dorsal unpaired median (DUM; DUM neurons), generate spontaneous repetitive action potentials. Short-term cultured adult DUM neurons isolated from the terminal abdominal ganglion (TAG) of the nerve cord were used to study the regulation of a tetrodotoxin-sensitive low-voltage-activated (LVA) channel permeable to sodium and calcium (Na/Ca), under whole cell voltage- and current-clamp conditions...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28567006/lateral-entorhinal-cortex-lesions-impair-local-spatial-frameworks
#19
Maneesh V Kuruvilla, James A Ainge
A prominent theory in the neurobiology of memory processing is that episodic memory is supported by contextually gated spatial representations in the hippocampus formed by combining spatial information from medial entorhinal cortex (MEC) with non-spatial information from lateral entorhinal cortex (LEC). However, there is a growing body of evidence from lesion and single-unit recording studies in rodents suggesting that LEC might have a role in encoding space, particularly the current and previous locations of objects within the local environment...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28553208/childhood-trauma-and-functional-connectivity-between-amygdala-and-medial-prefrontal-cortex-a-dynamic-functional-connectivity-and-large-scale-network-perspective
#20
Josh M Cisler
Altered functional connectivity (FC) between the medial prefrontal cortex (mPFC) and amygdala is widely implicated as a neural mechanism explaining risk for psychopathology among those exposed to early life trauma. Nonetheless, contemporary neuroimaging research has shifted toward large-scale network models of brain function, and it is not clear how this common bi-nodal finding fits into larger-scale network models. Here, using dynamic functional connectivity (DFC) approaches combined with large-scale network analyses, the larger role of bi-nodal FC between mPFC and amygdala among a sample of adolescent girls is investigated...
2017: Frontiers in Systems Neuroscience
journal
journal
42049
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"