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Frontiers in Neural Circuits

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https://www.readbyqxmd.com/read/28082872/reboxetine-improves-auditory-attention-and-increases-norepinephrine-levels-in-the-auditory-cortex-of-chronically-stressed-rats
#1
Catherine Pérez-Valenzuela, Macarena F Gárate-Pérez, Ramón Sotomayor-Zárate, Paul H Delano, Alexies Dagnino-Subiabre
Chronic stress impairs auditory attention in rats and monoamines regulate neurotransmission in the primary auditory cortex (A1), a brain area that modulates auditory attention. In this context, we hypothesized that norepinephrine (NE) levels in A1 correlate with the auditory attention performance of chronically stressed rats. The first objective of this research was to evaluate whether chronic stress affects monoamines levels in A1. Male Sprague-Dawley rats were subjected to chronic stress (restraint stress) and monoamines levels were measured by high performance liquid chromatographer (HPLC)-electrochemical detection...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28082871/sevoflurane-alters-spatiotemporal-functional-connectivity-motifs-that-link-resting-state-networks-during-wakefulness
#2
MohammadMehdi Kafashan, ShiNung Ching, Ben J A Palanca
Background: The spatiotemporal patterns of correlated neural activity during the transition from wakefulness to general anesthesia have not been fully characterized. Correlation analysis of blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI) allows segmentation of the brain into resting-state networks (RSNs), with functional connectivity referring to the covarying activity that suggests shared functional specialization. We quantified the persistence of these correlations following the induction of general anesthesia in healthy volunteers and assessed for a dynamic nature over time...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28066192/the-on-crossover-circuitry-shapes-spatiotemporal-profile-in-the-center-and-surround-of-mouse-off-retinal-ganglion-cells
#3
Jasdeep Sabharwal, Robert L Seilheimer, Cameron S Cowan, Samuel M Wu
Retinal ganglion cells (RGCs) are often grouped based on their functional properties. Many of these functional properties, such as receptive field (RF) size, are driven by specific retinal circuits. In this report, we determined the role of the ON bipolar cell (BC) mediated crossover circuitry in shaping the center and surround of OFF RGCs. We recorded from a large population of mouse RGCs using a multielectrode array (MEA) while pharmacologically removing the ON BC-mediated crossover circuit. OFF sustained and transient responses to whole field stimuli are lost under scotopic conditions, but maintained under photopic conditions...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28066191/maladaptive-synaptic-plasticity-in-l-dopa-induced-dyskinesia
#4
REVIEW
Qiang Wang, Wangming Zhang
The emergence of L-DOPA-induced dyskinesia (LID) in patients with Parkinson disease (PD) could be due to maladaptive plasticity of corticostriatal synapses in response to L-DOPA treatment. A series of recent studies has revealed that LID is associated with marked morphological plasticity of striatal dendritic spines, particularly cell type-specific structural plasticity of medium spiny neurons (MSNs) in the striatum. In addition, evidence demonstrating the occurrence of plastic adaptations, including aberrant morphological and functional features, in multiple components of cortico-basal ganglionic circuitry, such as primary motor cortex (M1) and basal ganglia (BG) output nuclei...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28066190/large-scale-cortical-functional-networks-associated-with-slow-wave-and-spindle-burst-related-spontaneous-activity
#5
REVIEW
David A McVea, Timothy H Murphy, Majid H Mohajerani
Cortical sensory systems are active with rich patterns of activity during sleep and under light anesthesia. Remarkably, this activity shares many characteristics with those present when the awake brain responds to sensory stimuli. We review two specific forms of such activity: slow-wave activity (SWA) in the adult brain and spindle bursts in developing brain. SWA is composed of 0.5-4 Hz resting potential fluctuations. Although these fluctuations synchronize wide regions of cortex, recent large-scale imaging has shown spatial details of their distribution that reflect underlying cortical structural projections and networks...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28066189/estimating-fast-neural-input-using-anatomical-and-functional-connectivity
#6
REVIEW
David Eriksson
In the last 20 years there has been an increased interest in estimating signals that are sent between neurons and brain areas. During this time many new methods have appeared for measuring those signals. Here we review a wide range of methods for which connected neurons can be identified anatomically, by tracing axons that run between the cells, or functionally, by detecting if the activity of two neurons are correlated with a short lag. The signals that are sent between the neurons are represented by the activity in the neurons that are connected to the target population or by the activity at the corresponding synapses...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28018182/mapping-horizontal-spread-of-activity-in-monkey-motor-cortex-using-single-pulse-microstimulation
#7
Yaoyao Hao, Alexa Riehle, Thomas G Brochier
Anatomical studies have demonstrated that distant cortical points are interconnected through long range axon collaterals of pyramidal cells. However, the functional properties of these intrinsic synaptic connections, especially their relationship with the cortical representations of body movements, have not been systematically investigated. To address this issue, we used multielectrode arrays chronically implanted in the motor cortex of two rhesus monkeys to analyze the effects of single-pulse intracortical microstimulation (sICMS) applied at one electrode on the neuronal activities recorded at all other electrodes...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28018181/spatial-distribution-of-attentional-modulation-at-columnar-resolution-in-macaque-area-v4
#8
Hisashi Tanigawa, Gang Chen, Anna W Roe
Attention to a location in a visual scene affects neuronal responses in visual cortical areas in a retinotopically specific manner. Optical imaging studies have revealed that cortical responses consist of two components of different sizes: the stimulus-nonspecific global signal and the stimulus-specific mapping signal (domain activity). It remains unclear whether either or both of these components are modulated by spatial attention. In this study, to determine the spatial distribution of attentional modulation at columnar resolution, we performed cerebral blood volume (CBV)-based optical imaging in area V4 of monkeys performing a color change detection task in which spatial attention was manipulated...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28018180/local-field-potentials-myths-and-misunderstandings
#9
REVIEW
Oscar Herreras
The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confounding factors and technical limitations. By and large, the main factor defining the amplitude of LFPs is the geometry of the current sources, over and above the degree of synchronization or the properties of the media...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27999532/genetic-feedback-regulation-of-frontal-cortical-neuronal-ensembles-through-activity-dependent-arc-expression-and-dopaminergic-input
#10
Surjeet Mastwal, Vania Cao, Kuan Hong Wang
Mental functions involve coordinated activities of specific neuronal ensembles that are embedded in complex brain circuits. Aberrant neuronal ensemble dynamics is thought to form the neurobiological basis of mental disorders. A major challenge in mental health research is to identify these cellular ensembles and determine what molecular mechanisms constrain their emergence and consolidation during development and learning. Here, we provide a perspective based on recent studies that use activity-dependent gene Arc/Arg3...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27965544/an-exploratory-study-of-spectroscopic-glutamatergic-correlates-of-cortical-excitability-in-depressed-adolescents
#11
Charles P Lewis, John D Port, Mark A Frye, Jennifer L Vande Voort, Stephanie H Ameis, Mustafa M Husain, Zafiris J Daskalakis, Paul E Croarkin
Introduction: Transcranial magnetic stimulation (TMS) research has suggested dysfunction in cortical glutamatergic systems in adolescent depression, while proton magnetic resonance spectroscopy ((1)H-MRS) studies have demonstrated deficits in concentrations of glutamatergic metabolites in depressed individuals in several cortical regions, including the anterior cingulate cortex (ACC). However, few studies have combined TMS and MRS methods to examine relationships between glutamatergic neurochemistry and excitatory and inhibitory neural functions, and none have utilized TMS-MRS methodology in clinical populations or in youth...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27965543/controllable-pulse-parameter-tms-and-tms-eeg-as-novel-approaches-to-improve-neural-targeting-with-rtms-in-human-cerebral-cortex
#12
Ricci Hannah, Lorenzo Rocchi, Sara Tremblay, John C Rothwell
No abstract text is available yet for this article.
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27965542/releasing-the-cortical-brake-by-non-invasive-electromagnetic-stimulation-rtms-induces-ltd-of-gabaergic-neurotransmission
#13
REVIEW
Maximilian Lenz, Andreas Vlachos
Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive brain stimulation technique which modulates cortical excitability beyond the stimulation period. However, despite its clinical use rTMS-based therapies which prevent or reduce disabilities in a functionally significant and sustained manner are scarce. It remains unclear how rTMS-mediated changes in cortical excitability, which are not task- or input-specific, exert beneficial effects in some healthy subjects and patients. While experimental evidence exists that repetitive magnetic stimulation (rMS) is linked to the induction of long-term potentiation (LTP) of excitatory neurotransmission, less attention has been dedicated to rTMS-induced structural, functional and molecular adaptations at inhibitory synapses...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27932957/emergence-of-selectivity-to-looming-stimuli-in-a-spiking-network-model-of-the-optic-tectum
#14
Eric V Jang, Carolina Ramirez-Vizcarrondo, Carlos D Aizenman, Arseny S Khakhalin
The neural circuits in the optic tectum of Xenopus tadpoles are selectively responsive to looming visual stimuli that resemble objects approaching the animal at a collision trajectory. This selectivity is required for adaptive collision avoidance behavior in this species, but its underlying mechanisms are not known. In particular, it is still unclear how the balance between the recurrent spontaneous network activity and the newly arriving sensory flow is set in this structure, and to what degree this balance is important for collision detection...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27932956/hypothalamic-vasopressinergic-projections-innervate-central-amygdala-gabaergic-neurons-implications-for-anxiety-and-stress-coping
#15
Vito S Hernández, Oscar R Hernández, Miguel Perez de la Mora, María J Gómora, Kjell Fuxe, Lee E Eiden, Limei Zhang
The arginine-vasopressin (AVP)-containing hypothalamic magnocellular neurosecretory neurons (VPMNNs) are known for their role in hydro-electrolytic balance control via their projections to the neurohypophysis. Recently, projections from these same neurons to hippocampus, habenula and other brain regions in which vasopressin infusion modulates contingent social and emotionally-affected behaviors, have been reported. Here, we present evidence that VPMNN collaterals also project to the amygdaloid complex, and establish synaptic connections with neurons in central amygdala (CeA)...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27899883/commentary-melanopsin-regulates-both-sleep-promoting-and-arousal-promoting-responses-to-light
#16
COMMENT
Christian Cajochen, Sarah L Chellappa
No abstract text is available yet for this article.
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27895555/spike-timing-rigidity-is-maintained-in-bursting-neurons-under-pentobarbital-induced-anesthetic-conditions
#17
Risako Kato, Masanori Yamanaka, Eiko Yokota, Noriaki Koshikawa, Masayuki Kobayashi
Pentobarbital potentiates γ-aminobutyric acid (GABA)-mediated inhibitory synaptic transmission by prolonging the open time of GABAA receptors. However, it is unknown how pentobarbital regulates cortical neuronal activities via local circuits in vivo. To examine this question, we performed extracellular unit recording in rat insular cortex under awake and anesthetic conditions. Not a few studies apply time-rescaling theorem to detect the features of repetitive spike firing. Similar to these methods, we define an average spike interval locally in time using random matrix theory (RMT), which enables us to compare different activity states on a universal scale...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27891080/enhanced-burst-suppression-and-disruption-of-local-field-potential-synchrony-in-a-mouse-model-of-focal-cortical-dysplasia-exhibiting-spike-wave-seizures
#18
Anthony J Williams, Chen Zhou, Qian-Quan Sun
Focal cortical dysplasias (FCDs) are a common cause of brain seizures and are often associated with intractable epilepsy. Here we evaluated aberrant brain neurophysiology in an in vivo mouse model of FCD induced by neonatal freeze lesions (FLs) to the right cortical hemisphere (near S1). Linear multi-electrode arrays were used to record extracellular potentials from cortical and subcortical brain regions near the FL in anesthetized mice (5-13 months old) followed by 24 h cortical electroencephalogram (EEG) recordings...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27891079/contribution-of-tms-and-rtms-in-the-understanding-of-the-pathophysiology-and-in-the-treatment-of-dystonia
#19
REVIEW
Pierre Lozeron, Aurélia Poujois, Alexandra Richard, Sana Masmoudi, Elodie Meppiel, France Woimant, Nathalie Kubis
Dystonias represent a heterogeneous group of movement disorders responsible for sustained muscle contraction, abnormal postures, and muscle twists. It can affect focal or segmental body parts or be generalized. Primary dystonia is the most common form of dystonia but it can also be secondary to metabolic or structural dysfunction, the consequence of a drug's side-effect or of genetic origin. The pathophysiology is still not elucidated. Based on lesion studies, dystonia has been regarded as a pure motor dysfunction of the basal ganglia loop...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27891078/neural-and-response-correlations-to-complex-natural-sounds-in-the-auditory-midbrain
#20
Dominika Lyzwa, Florentin Wörgötter
How natural communication sounds are spatially represented across the inferior colliculus, the main center of convergence for auditory information in the midbrain, is not known. The neural representation of the acoustic stimuli results from the interplay of locally differing input and the organization of spectral and temporal neural preferences that change gradually across the nucleus. This raises the question of how similar the neural representation of the communication sounds is across these gradients of neural preferences, and whether it also changes gradually...
2016: Frontiers in Neural Circuits
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