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Multidisciplinary Respiratory Medicine

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https://www.readbyqxmd.com/read/28904792/desmoplastic-small-round-cell-tumors-of-the-pleura-a-review-of-the-clinical-literature
#1
REVIEW
Alessandro Giuseppe Fois, Pietro Pirina, Antonella Arcadu, Francesca Becciu, Sandra Manca, Viviana Marras, Sara Canu, Gaetano Castagna, Giorgio Carlo Ginesu, Angelo Zinellu, Panagiotis Paliogiannis
Desmoplastic small round cell tumor of the pleura is a rare malignancy, with only a few cases reported in the scientific literature. The aim of the present review is to discuss the demographic, pathological, clinical, and therapeutic features of this rare tumor. English-language articles published since 1989, when the first case of desmoplastic small round cell tumor of the pleura was described, were retrieved, and fifteen cases included in fourteen articles were revised. The mean age of the patients was 25...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28835819/could-eosinophilia-predict-clinical-severity-in-nasal-polyps
#2
Figen Aslan, Eren Altun, Serpil Paksoy, Gulay Turan
BACKGROUND: Although nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis of the disease. Aim of this study was to investigate the relation between mucosal and peripheral eosinophilia and their relation with disease severity in nasal polyps. METHODS: The study included 53 patients with nasal polyps who underwent endoscopic sinus surgery...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28794876/the-history-and-epidemiology-of-middle-east-respiratory-syndrome-corona-virus
#3
REVIEW
Aisha M Al-Osail, Marwan J Al-Wazzah
Corona viruses cause common cold, and infections caused by corona viruses are generally self-resolving. During the last 4 years, corona viruses have become the most important viruses worldwide because of the occurrence of several recent deaths caused by corona viruses in Saudi Arabia. Spread of the infection occurred worldwide; however, most cases of mortality have occurred in the Middle East. Owing to the predominance of outbreaks in the Middle Eastern countries, the virus was renamed a Middle East respiratory syndrome corona virus (MERS-CoV) by the Corona virus Study Group...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28725424/implementation-of-gold-consensus-report-in-real-life-results-from-the-velletri-lariano-vela-cohort
#4
G De Filippi, M Lallini, G De Riggi, G Marchetti, C M Dimartino, A M Russetti, E Ferrari, R Pistelli, M S Magnoni, M Riparbelli, A Rizzi, P Angeletti
BACKGROUND: COPD is one of the leading causes of morbidity and mortality. Pharmacotherapy improves quality of life and reduces exacerbations although low adherence with prescribed treatments may represent a barrier to optimal disease management. The first objective of this paper is to report the distribution of COPD patients according to GOLD categories, in a sample of patients from a cohort study in an area of the Latium region in Italy. The second objective is to evaluate the agreement between the distributions of severity obtained from the HCPs and the experts included in the study board (Board)...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28670453/novel-aspects-in-diagnostic-approach-to-respiratory-patients-is-it-the-time-for-a-new-semiotics
#5
Gino Soldati, Andrea Smargiassi, Alberto A Mariani, Riccardo Inchingolo
Medical approach to patients is a fundamental step to get the correct diagnosis. The aim of this paper is to analyze some aspects of the reasoning process inherent in medical diagnosis in our era. Pathologic signs (anamnestic data, symptoms, semiotics, laboratory and strumental findings) represent informative phenomena to be integrated for inferring a diagnosis. Thus, diagnosis begins with "signs" and finishes in a probability of disease. The abductive reasoning process is the generation of a hypothesis to explain one or more observations (signs) in order to decide between alternative explanations searching the best one...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28652914/erratum-to-recent-advances-in-capsule-based-dry-powder-inhaler-technology
#6
Federico Lavorini, Massimo Pistolesi, Omar S Usmani
[This corrects the article DOI: 10.1186/s40248-017-0092-5.].
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28593046/erratum-to-the-evidence-on-tiotropium-bromide-in-asthma-from-the-rationale-to-the-bedside
#7
Dejan Radovanovic, Pierachille Santus, Francesco Blasi, Marco Mantero
[This corrects the article DOI: 10.1186/s40248-017-0094-3.].
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28560038/mutational-status-predicts-the-risk-of-thromboembolic-events-in-lung-adenocarcinoma
#8
Elsa Davidsson, Nicola Murgia, Cristian Ortiz-Villalón, Emil Wiklundh, Magnus Sköld, Karl Gustav Kölbeck, Giovanni Ferrara
BACKGROUND: Precision medicine promises to improve prognosis of patients affected by untreatable diseases. Patients with lung cancer (especially lung adenocarcinoma) bear an increased risk of VTE. Mutations in the EGFR and rearrangement in the ALK genes identify specific subgroups of patients. Aim of this study was to investigate the role of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutational status on the risk of venous thromboembolism (VTE) in lung adenocarcinoma...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28560037/instant-velocity-and-consistency-of-emitted-cloud-change-by-the-different-levels-of-canister-filling-with-metered-dose-inhalers-mdis-but-not-with-soft-mist-inhalers-smis-a%C3%A2-bench-study
#9
Roberto W Dal Negro, Pietro Longo, Orestepaolo Villanis Ziani, Luca Bonadiman, Paola Turco
BACKGROUND: Inhalation is the preferred route for respiratory drug delivery, but several factors contribute to the variability of the respirable dose fraction. Instant velocity and the dynamic characteristics of the droplet cloud represent crucial factors. Aim was to measure and compare the instant velocity and the consistency of emitted cloud from five different MDIs (A - Salbutamol sulphate 100mcg, GSK; B - Salbutamol sulphate 100mcg, Valeas; C - Salmeterol xinafoate/Fluticasone propionate 25/125mcg, GSK; D - Formoterol fumarate/Bechlomethasone propionate 6/100mcg, Chiesi; E - Formoterol fumarate/Fluticasone dipropionate 5/125mcg, Mundipharma) and one SMI (Tiotropium bromide 5mcg, Boehringer Ingelheim), at different distance from the nozzle and canister filling...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28536654/recent-advances-in-capsule-based-dry-powder-inhaler-technology
#10
REVIEW
Federico Lavorini, Massimo Pistolesi, Omar S Usmani
Pulmonary drug delivery is currently the focus of accelerated research and development because of the potential to produce maximum therapeutic benefit to patients by directly targeting drug to the site of pathology in the lungs. Among the available delivery options, the dry powder inhaler (DPI) is the preferred device for the treatment of an increasingly diverse range of diseases. However, because drug delivery from a DPI involves a complex interaction between the device and the patient, the engineering development of this medical technology is proving to be a great challenge...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28533903/using-paco2-values-to-grade-obesity-hypoventilation-syndrome-severity-a-retrospective-study
#11
Mario Francesco Damiani, Vito Antonio Falcone, Pierluigi Carratù, Cristina Scoditti, Elioda Bega, Silvano Dragonieri, Alfredo Scoditti, Onofrio Resta
BACKGROUND: To date, an important aspect that has still not been clarified is the assessment of OHS severity. The purpose of this retrospective study was to evaluate whether grading OHS severity according to PaCO2 values may be useful in order to provide a more definite characterization and targeted management of patients. In this regard, baseline anthropometric and sleep polygraphic characteristics, treatment options, and follow up outcomes, were compared between OHS patients with different degree of severity (as assessed according to PaCO2 values)...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28503304/clinico-pathologic-presentation-of-hypersensitivity-pneumonitis-in-egyptian-patients-a-multidisciplinary-study
#12
Dalia Abd El-Kareem, Yosri M Akl, Gina A Nakhla, Ali A Elhindawi, Mahmoud A Eltorky
BACKGROUND: Hypersensitivity pneumonitis (HP) is a common diffuse parenchymal lung disease in Egypt which can be difficult to recognize due to the dynamic symptoms & associated environmental factors. METHODS: Forty-three Egyptian patients were enrolled in this study, presenting with dyspnea and cough, predominant ground-glass opacity (GGO) in high-resolution computed tomography (HRCT) where lung biopsy was needed to establish the diagnosis. RESULTS: The age range was 15 to 60 years...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28484598/the-evidence-on-tiotropium-bromide-in-asthma-from-the-rationale-to-the-bedside
#13
REVIEW
Dejan Radovanovic, Pierachille Santus, Francesco Blasi, Marco Mantero
Severe and poorly controlled asthma still accounts for a great portion of the patients affected. Disease control and future risk management have been identified by international guidelines as the main goals in patients with asthma. The need for new treatment approaches has led to reconsider anticholinergic drugs as an option for asthma treatment. Tiotropium is the first anticholinergic drug that has been approved for children and adults with poorly controlled asthma and is currently considered as an option for steps 4 and 5 of the Global Initiative for Asthma...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28435672/tele-medicine-in-respiratory-diseases
#14
REVIEW
Nicolino Ambrosino, Dewi Nurul Makhabah, Yusup Subagio Sutanto
Information and Communication Technologies applied to health care and advances in sensor and data transmission technology allowed tele-medicine based programs of care also for patients with respiratory diseases. Different sensors, transmission devices and interventions are used in tele-medicine for some indications. Patients suffering from Chronic Obstructive Pulmonary Disease, asthma, neuromuscular diseases, ventilator assisted individuals and those undergoing pulmonary rehabilitation programs may benefit from this approach...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28400960/longitudinal-assessment-of-bleomycin-induced-lung-fibrosis-by-micro-ct-correlates-with-histological-evaluation-in-mice
#15
Francesca Ruscitti, Francesca Ravanetti, Jeroen Essers, Yanto Ridwan, Sasha Belenkov, Wim Vos, Francisca Ferreira, Alex KleinJan, Paula van Heijningen, Cedric Van Holsbeke, Antonio Cacchioli, Gino Villetti, Franco Fabio Stellari
BACKGROUND: The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development of inflammation followed by fibrotic tissue changes and represents the most widely used model of pulmonary fibrosis to investigate human IPF. Histopathology is the gold standard for assessing lung fibrosis in rodents, however it precludes repeated and longitudinal measurements of disease progression and does not provide information on spatial and temporal distribution of tissue damage...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28331610/a-reappraisal-of-the-mucoactive-activity-and-clinical-efficacy-of-bromhexine
#16
REVIEW
Alessandro Zanasi, Massimiliano Mazzolini, Ahmad Kantar
Since its introduction to the market in 1963, bromhexine, an over-the-counter drug, has been investigated for its activity in animal models and in humans with diverse respiratory conditions. Bromhexine is a derivate of the Adhatoda vasica plant used in some countries for the treatment of various respiratory diseases. Bromhexine has been found to enhance the secretion of various mucus components by modifying the physicochemical characteristics of mucus. These changes, in turn, increase mucociliary clearance and reduce cough...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28316784/characteristics-of-an-optimized-patient-information-material-for-elderly-patients-with-obstructive-pulmonary-diseases-based-on-patients-and-experts-assessment
#17
Gábor Tomisa, Alpár Horváth, Brigitta Dombai, Lilla Tamási
BACKGROUND: Life-long regular use of drugs is necessary in chronic diseases like asthma and COPD. There are several methods to improve adherence including patient information and education; however, their effectiveness on the basis of practical experience is often lower than originally planned and expected. Our objective is to develop a patient information material based on the recommendations of patients and their treating healthcare professionals to fulfill their needs. METHODS: A survey was conducted among pulmonologists (N = 262), asthma nurses (N = 102), general practitioners (N = 321) and patients with obstructive pulmonary disease (N = 978) using on line questionnaires...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28261477/ventilator-associated-pneumonia-or-ventilator-induced-pneumonia
#18
Zahid Hussain Khan, Piero Ceriana, Claudio F Donner
Ventilator associated pneumonia currently in vogue seems to have some pitfalls as far as the nomenclature is concerned and thus it imparts an erroneous impression to the reader. As the driving force is in fact the ventilator, the phraseology should preferably be changed to ventilator induced pneumonia to convey the in depth meaning of the term thus evading the terminology currently in practice. A new and emerging paradigm dealing with all side effects of mechanical ventilation can be helpful to solve this etymological conflict...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28239460/each-day-is-a-new-beginning
#19
EDITORIAL
Francesco Blasi, Claudio M Sanguinetti
No abstract text is available yet for this article.
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28194273/the-physiological-basis-and-clinical-significance-of-lung-volume-measurements
#20
REVIEW
Mohamed Faisal Lutfi
From a physiological standpoint, the lung volumes are either dynamic or static. Both subclasses are measured at different degrees of inspiration or expiration; however, dynamic lung volumes are characteristically dependent on the rate of air flow. The static lung volumes/capacities are further subdivided into four standard volumes (tidal, inspiratory reserve, expiratory reserve, and residual volumes) and four standard capacities (inspiratory, functional residual, vital and total lung capacities). The dynamic lung volumes are mostly derived from vital capacity...
2017: Multidisciplinary Respiratory Medicine
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