journal
MENU ▼
Read by QxMD icon Read
search

Advances in Urology

journal
https://www.readbyqxmd.com/read/29736168/conventional-dose-versus-high-dose-chemotherapy-for-relapsed-germ-cell-tumors
#1
REVIEW
Deaglan J McHugh, Darren R Feldman
The majority of metastatic germ cell tumors (GCTs) are cured with cisplatin-based chemotherapy, but 20-30% of patients will relapse after first-line chemotherapy and require additional salvage strategies. The two major salvage approaches in this scenario are high-dose chemotherapy (HDCT) with autologous stem cell transplant (ASCT) or conventional-dose chemotherapy (CDCT). Both CDCT and HDCT have curative potential in the management of relapsed/refractory GCT. However, due to a lack of conclusive randomized trials, it remains unknown whether sequential HDCT or CDCT represents the optimal initial salvage approach, with practice varying between tertiary institutions...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29725351/immune-related-concepts-in-biology-and-treatment-of-germ-cell-tumors
#2
REVIEW
Michal Chovanec, Ugo De Giorgi, Michal Mego
Germ-cell tumors (GCTs) are highly curable with chemotherapy. Salvage chemotherapy or surgery can cure a proportion of patients, but the ones failing these treatments will die of their disease in the young age. Immune checkpoint pathways are emerging as powerful targetable biomarkers, and a significant preclinical and clinical research is underway to widen our knowledge and expand the treatment possibilities with immune therapy. The concept of immune modulation that was currently adopted in many solid tumors is understudied in GCTs...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29725350/urinary-bladder-cancer-in-egypt-are-there-gender-differences-in-its-histopathological-presentation
#3
Fiorina Kyritsi, Christopher A Loffredo, Yun-Ling Zheng, George Philips, Sania Amr
We investigated gender differences in the histopathologic presentation of bladder cancer cases in Egypt, where both urothelial cell carcinoma (UC) and squamous cell carcinoma (SCC) types are highly prevalent. We used logistic regression to estimate the unadjusted (OR) and adjusted odds ratio (AOR) and 95% confidence interval (CI) of the associations between gender and different histopathologic and sociodemographic parameters of 2,186 confirmed cases of primary bladder cancer (1,775 males and 411 females; 784 SCC and 1,402 UC)...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29713340/supine-percutaneous-nephrolithotripsy-in-double-s-position
#4
Giuseppe Giusti, Antonello De Lisa
Background: At present, the percutaneous nephrolithotripsy (PCNL) is performed both in supine and in prone position. The aim of this paper is to describe an innovative position during PCNL. Methods: We describe a supine position. The patient's legs are slightly abducted at the hips. The thorax is laterally tilted (inclination 30°-35°) and kept in the right position by one or two gel pads placed between the scapula and the vertebrae. External genitalia can be accessed at any time, so that it is always possible to use flexible instruments in the upper urinary tract...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29670654/toxicities-associated-with-cisplatin-based-chemotherapy-and-radiotherapy-in-long-term-testicular-cancer-survivors
#5
REVIEW
Chunkit Fung, Paul Dinh, Shirin Ardeshir-Rouhani-Fard, Kerry Schaffer, Sophie D Fossa, Lois B Travis
Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro- and ototoxicity, pulmonary complications, nephrotoxicity, hypogonadism, infertility, and avascular necrosis...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29670653/dissecting-the-evolving-risk-of-relapse-over-time-in-surveillance-for-testicular-cancer
#6
REVIEW
Madhur Nayan, Robert J Hamilton
Testicular cancer is the most common malignancy in young men, and the incidence is increasing in most countries worldwide. The vast majority of patients present with clinical stage I disease, and surveillance is being increasingly adopted as the preferred management strategy. At the time of diagnosis, patients on surveillance are often counselled about their risk of relapse based on risk factors present at diagnosis, but this risk estimate becomes less informative in patients that have survived a period of time without experiencing relapse...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29670652/combined-dorsal-and-ventral-onlay-buccal-graft-technique-for-large-and-complex-penile-strictures
#7
Nikolaos Mertziotis, Andreas Konandreas, Christos Kyratsas
Purpose: To present a modified technique of managing extensive penile urethral strictures with dorsal and ventral onlay buccal mucosa grafts. Patients and Methods: From October 2014 to January 2016, a total of 12 patients underwent urethroplasty for penile urethral strictures, using dorsal and ventral onlay grafts from buccal mucosa. The mean age was 42.75 (17-71). All patients completed the IPSS and QoL questionnaire, and uroflowmetry was done preoperatively. After surgery, the follow-up included completion of IPSS and QoL questionnaire and measuring of uroflow at 1, 3, 6, and 12 months...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29662516/adolescent-and-young-adult-testicular-germ-cell-tumors-special-considerations
#8
REVIEW
Amanda F Saltzman, Nicholas G Cost
While testicular germ cell tumors (T-GCTs) make up only 0.5% of pediatric malignancies and less than 2% of adult malignancies, they comprise 14% of adolescent malignancies, making it the most common solid tumor in this age group. The transition in incidence at this age is also accompanied by a transition in tumor histology with adolescents having mostly pure embryonal carcinoma and mixed nonseminomatous germ cell tumors. Similar to T-GCTs of all ages, surgical excision with orchiectomy is the standard initial step in treatment...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29515628/pediatric-germ-cell-tumors-a-developmental-perspective
#9
REVIEW
Joshua L Pierce, A Lindsay Frazier, James F Amatruda
Germ cell tumors (GCTs) arising in infants, children, and adolescents present a set of special challenges. GCTs make up about 3% of malignancies in children aged 0-18 and nearly 15% of cancers in adolescents. Epidemiologic and molecular evidence suggests that GCTs in young children likely represent a distinct biologic group as compared to GCTs of older adolescents and adults. Despite this difference, pediatric GCTs are typically treated with cisplatin-based multiagent regimens similar to those used in adults...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29515627/kidney-stone-disease-an-update-on-current-concepts
#10
REVIEW
Tilahun Alelign, Beyene Petros
Kidney stone disease is a crystal concretion formed usually within the kidneys. It is an increasing urological disorder of human health, affecting about 12% of the world population. It has been associated with an increased risk of end-stage renal failure. The etiology of kidney stone is multifactorial. The most common type of kidney stone is calcium oxalate formed at Randall's plaque on the renal papillary surfaces. The mechanism of stone formation is a complex process which results from several physicochemical events including supersaturation, nucleation, growth, aggregation, and retention of urinary stone constituents within tubular cells...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29487620/retroperitoneal-lymph-node-dissection-as-primary-treatment-for-metastatic-seminoma
#11
REVIEW
Brian Hu, Siamak Daneshmand
Reducing the long-term morbidity in testicular cancer survivors represents a major area of interest. External beam radiation therapy and systemic chemotherapy are established treatments for seminoma; however, they are associated with late toxicities such as cardiovascular disease, insulin resistance, and secondary malignancy. Retroperitoneal lymph node dissection (RPLND) is a standard treatment for nonseminomatous germ cell tumors (NSGCT) that has minimal long-term morbidity. Given the efficacy of RPLND in management of NSGCT, interest has developed in this surgery as a front-line treatment for seminoma with isolated lymph node metastasis to the retroperitoneum...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29527225/spermatozoal-fractalkine-signaling-pathway-is-upregulated-in-subclinical-varicocele-patients-with-normal-seminogram-and-low-level-leucospermia
#12
Salwa M Abo El-Khair, Mohammad A Gaballah, Mamdouh M Abdel-Gawad, Sherif Refaat M Ismail, Ayman Z Elsamanoudy
Background: Fractalkine is produced in seminal plasma in small amounts and correlates with sperm motility. Purpose: To investigate the possible effect of low-level leucospermia on spermatozoa oxidative stress and sDNA fragmentation in patients with subclinical varicocele and apparently normal seminogram, and also to study the role of spermatozoal fractalkine and its receptor (CX3CR1) gene expression as a marker of spermatozoa inflammatory response. Methods: This study included 80 patients with subclinical varicocele (45 fertile and 35 infertile) and 45 age-matched fertile volunteers...
2017: Advances in Urology
https://www.readbyqxmd.com/read/29430250/impact-on-the-quality-of-erections-after-completing-a-low-intensity-extracorporeal-shock-wave-treatment-cycle-on-a-group-of-710-patients
#13
Héctor A Corredor Ayala, José Pablo Saffon Cuartas, Diana Cerquera Cleves
Objective: The aim of this study is to evaluate the response to low-intensity extracorporeal shock wave therapy in a group of patients with organic vascular erectile dysfunction. Materials and Methods: This is an observational retrospective study. The researchers reviewed 710 patients with a clinical diagnosis of organic vascular erectile dysfunction (ED) of more than 3-month duration from male sexual health clinics of the Boston Medical Group from 12 cities in Spain and 4 in Mexico...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28744308/recent-pathophysiological-aspects-of-peyronie-s-disease-role-of-free-radicals-rationale-and-therapeutic-implications-for-antioxidant-treatment-literature-review
#14
REVIEW
Gianni Paulis, Gennaro Romano, Luca Paulis, Davide Barletta
Peyronie's disease (PD) is a chronic inflammation of tunica albuginea of the corpora cavernosa that causes an inelastic plaque resulting in penis deformation. Although its etiology is not completely known, there is general consensus that PD is genetically transmitted and secondary to penile trauma. In recent years, numerous studies demonstrated the role played by oxidative stress in PD pathogenesis, and other studies have described successful use of antioxidants in PD treatment. Oxidative stress is an integral part of this disease, influencing its progression...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28694823/the-persistence-of-silodosin-monotherapy-and-the-reasons-for-withdrawal-from-treatment-of-previously-untreated-japanese-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia
#15
Yoshinori Tanaka, Yasushi Tanuma, Naoya Masumori
OBJECTIVES: The persistence of silodosin and the reasons for withdrawal from treatment of previously untreated Japanese patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) were evaluated in real-life clinical practice. METHODS: A total of 81 previously untreated Japanese patients diagnosed with LUTS/BPH were treated with silodosin monotherapy and prospectively followed for 4 years. The persistence rate was estimated using the Kaplan-Meier method...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28634489/a-study-of-patients-with-primary-mediastinal-germ-cell-tumors-treated-using-multimodal-therapy
#16
Yutaro Tanaka, Takehiko Okamura, Takashi Nagai, Daichi Kobayashi, Takahiro Kobayashi, Hidetoshi Akita, Yoshinobu Moritoki, Takahiro Yasui
OBJECTIVES: Primary mediastinal germ cell tumors (PMGCTs) are rare, which often makes them difficult to treat. Herein, we examined patients with PMGCTs who underwent multimodal treatment. METHODS: We examined 6 patients (median age: 25 years, range: 19-27 years) with PMGCTs who underwent multimodal treatment between April 2001 and March 2015. Three patients had seminomas, 2 patients had yolk sac tumors, and 1 patient had choriocarcinoma. The median observation period was 32...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28607553/study-of-testicular-structure-in-fetuses-with-prune-belly-syndrome
#17
Luciano A Favorito, Suelen F Costa, Waldemar S Costa, Rodrigo Vieiralves, Fabio O Bernardo, Francisco J B Sampaio
PURPOSE: To compare the structure of the testis in fetuses with prune belly syndrome (PBS) to normal controls. MATERIALS AND METHODS: We studied 6 testes obtained from 3 fetuses with PBS and 14 testes from 7 male fetuses. The testicular specimens were cut into 5- μ m thick sections and stained with hematoxylin and eosin (HE), to observe the seminiferous tubules; Weigert's solution to observe elastic fibers; and picrosirius red to observe collagen. The images were captured with an Olympus BX51 microscope and Olympus DP70 camera...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28487733/do-routine-preoperative-and-intraoperative-urine-cultures-benefit-pediatric-vesicoureteral-reflux-surgery
#18
Daniel R Hettel, Bradley C Gill, Audrey C Rhee
Objective . To determine if routine preoperative and intraoperative urine cultures (UCx) are necessary in pediatric vesicoureteral (VUR) reflux surgery by identifying their association with each other, preoperative symptoms, and surgical outcomes. Materials and Methods . A retrospective review of patients undergoing ureteral reimplant(s) for primary VUR at a tertiary academic medical center between years 2000 and 2014 was done. Preoperative UCx were defined as those within 30 days before surgery. A positive culture was defined as >50,000 colony forming units of a single organism...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28465682/incidence-of-urethral-stricture-in-patients-with-adult-acquired-buried-penis
#19
Aron Liaw, Lanette Rickborn, Christopher McClung
Introduction . Concealed-buried penis is an acquired condition associated with obesity, challenging to both manage and repair. Urethral stricture is a more common disorder with multiple etiologies. Lichen sclerosus is a significant known cause of urethral stricture, implicated in up to 30%. We hypothesize that patients with buried penis have a higher rate of urethral stricture and lichen sclerosus than the general population. Methods . We retrospectively reviewed a single surgeon's (CM) case logs for patients presenting with a buried penis...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28348583/distribution-of-neuroendocrine-cells-in-the-transition-zone-of-the-prostate
#20
Yuki Kyoda, Koji Ichihara, Kohei Hashimoto, Ko Kobayashi, Fumimasa Fukuta, Naoya Masumori
Objectives . To evaluate the distribution of neuroendocrine (NE) cells which may influence the development of benign prostatic hyperplasia (BPH) in the transition zone (TZ). Methods . We reviewed specimens from 80 patients who underwent radical prostatectomy in our institution and evaluated the density of NE cells in the TZ. They were histologically classified into 3 groups: those with no adenomatous nodule in the TZ (group A), those with small nodules with normal epithelium and stroma around them in the TZ (group B), and those with large nodules occupying the TZ (group C)...
2017: Advances in Urology
journal
journal
42025
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"