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Patient Preference and Adherence

Mark Lemstra, Chijioke Nwankwo, Yelena Bird, John Moraros
Background: Medication nonadherence is a global problem that requires urgent attention. Primary nonadherence occurs when a patient consults with a medical doctor, receives a referral for medical therapy but never fills the first dispensation for the prescription medication. Nonadherence to chronic disease medications costs the USA ~$290 billion (USD) every year in avoidable health care costs. In Canada, it is estimated that 5.4% of all hospitalizations are due to medication nonadherence...
2018: Patient Preference and Adherence
Francesco Giorgino, Alfred Penfornis, Valeria Pechtner, Raffaella Gentilella, Antonella Corcos
Adherence to antihyperglycemic medications is often suboptimal in patients with type 2 diabetes, and this can contribute to poor glycemic control, increased hospitalization, and the development of diabetic complications. Reported adherence rates to antihyperglycemics vary widely among studies, and this may be related to differences in methodology for measuring adherence, patient populations, and other factors. Poor adherence may occur regardless of the specific regimen used and whether therapy is oral or injectable, and can be especially common in chronic, asymptomatic conditions, such as type 2 diabetes...
2018: Patient Preference and Adherence
Huiwen Zhao, Zhe Dong, Fei Xie, Guanxin Wang, Zhihua Wen, Lixia Zhang, Mwidimi Ndosi, Wen Luo
Background: Patient education is an integral part of the management of osteoarthritis. The educational needs assessment tool (ENAT) was developed in the UK to help direct needs-based patient education in rheumatic diseases. Aim: The aim of the study was to adapt and validate the ENAT into Chinese, for use in severe knee osteoarthritis (KOA). Methods: This cross-cultural validation study took two phases: 1) adaptation of the ENAT into Chinese (CENAT) and 2) validation of the CENAT...
2018: Patient Preference and Adherence
Kanglai Li, Jiong Tao, Yuemei Li, Minhua Chen, Xiuhua Wu, Yingtao Liao, Xiaolan Lin, Zhaoyu Gan
Background: The aim of the study was to describe and compare the patterns of medication persistence among patients with unipolar depression (UD) or bipolar depression in a 5-year follow-up, and explore their impact on long-term outcome. Patients and methods: A total of 333 eligible patients with current major depressive episode were observed and followed up from the first index prescription for 5 years. Lack of persistence or treatment interruption was defined as a gap of at least 2 consecutive months without taking any medication...
2018: Patient Preference and Adherence
Jui-Hua Tsai, Ellen Janssen, John Fp Bridges
Patient groups are increasingly engaging in research to understand patients' preferences and incorporate their perspectives into drug development and regulation. Several models of patient engagement have emerged, but there is little guidance on how to partner with patient groups to engage the disease community. Our group has been using an approach to engage patient groups that we call research as an event. Research as an event is a method for researchers to use a community-centered event to engage patients in their own environment at modest incremental cost...
2018: Patient Preference and Adherence
Yi-Ju Lin, Chin-Yuan Wang, Elizabeth H Chang, Ssu-Wei Cheng, Yu Ko
Objective: The aim of this study was to translate, adapt, and validate the Satisfaction with Oral Anti-Diabetic Agent Scale (SOADAS) in type 2 diabetes mellitus (DM) patients taking oral antidiabetic drugs (OADs) in Taiwan. Patients and methods: The SOADAS was translated to Chinese and was modified based on reviews of two physicians, five diabetes educators, and two patient focus groups. A cross-sectional interviewer-administered survey was conducted in adult patients with type 2 DM who were taking OADs...
2018: Patient Preference and Adherence
Hector Beltran-Alacreu, Ibai López-de-Uralde-Villanueva, César Calvo-Lobo, Roy La Touche, Roberto Cano-de-la-Cuerda, Alfonso Gil-Martínez, David Fernández-Ayuso, Josué Fernández-Carnero
Purpose: The main aim of the study was to predict the health-related quality of life (HRQoL) based on physical, functional, and psychological measures in patients with different types of neck pain (NP). Materials and methods: This cross-sectional study included 202 patients from a primary health center and the physiotherapy outpatient department of a hospital. Patients were divided into four groups according to their NP characteristics: chronic (CNP), acute whiplash (WHIP), chronic NP associated with temporomandibular dysfunction (NP-TMD), or chronic NP associated with chronic primary headache (NP-PH)...
2018: Patient Preference and Adherence
John Fp Bridges, Allison H Oakes, Crystal A Reinhart, Ernest Voyard, Bernadette O'Donoghue
Background: Acute myeloid leukemia (AML) is a rapidly progressing blood cancer for which new treatments are needed. We sought to promote patient-focused drug development (PFDD) for AML by developing and piloting an instrument to prioritize the worries of patients with AML. Patients and methods: An innovative community-centered approach was used to engage expert and community stakeholders in the development, pretesting, pilot testing, and dissemination of a novel best-worst scaling instrument...
2018: Patient Preference and Adherence
Mara Z Vitolins, L Douglas Case, Stephen R Rapp, Mark O Lively, Edward G Shaw, Michelle J Naughton, Jeffrey Giguere, Glenn J Lesser
Purpose: Women with breast cancer were randomized to receive coenzyme Q10 (CoQ10) plus Vitamin E or placebo in a clinical trial. The objective of this evaluation is to examine the association between participant self-reported adherence to the study supplements and changes in plasma biomarker levels. Patients and methods: Correlation coefficients quantified the association between changes in alpha-tocopherol and CoQ10 levels and the association between self-reported adherence and changes in biomarkers...
2018: Patient Preference and Adherence
Ioan Tilea, Dorina Petra, Septimiu Voidazan, Elena Ardeleanu, Andreea Varga
Purpose: This study was performed to elucidate the level of adherence to antihypertensive treatment in adult subjects attending a family medicine clinic in a city in central Romania. Patients and methods: A cross-sectional, retrospective study was performed on a cohort of hypertensive adults. A total of 525 participants were selected from 1,714 adults attending a single urban family medicine practice. Assessment of adherence to therapy was performed by a chart review of prescription and clinical records over a 4-year study period...
2018: Patient Preference and Adherence
Yew Keong Ng, Noraida Mohamed Shah, Ly Sia Loong, Lay Ting Pee, Sarina Anim M Hidzir, Wei Wen Chong
Purpose: This study investigated patients' and pharmacists' attitudes toward concordance in a pharmacist-patient consultation and how patients' attitudes toward concordance relate to their involvement and self-efficacy in decision making associated with medication use. Subjects and methods: A cross-sectional study was conducted among patients with chronic diseases and pharmacists from three public hospitals in Malaysia. The Revised United States Leeds Attitudes toward Concordance (RUS-LATCon) was used to measure attitudes toward concordance in both patients and pharmacists...
2018: Patient Preference and Adherence
Hui Yang, Xia Xie, Yuqing Song, Anliu Nie, Hong Chen
Purpose: The aim of this study was to estimate the level of self-care agency and explore its associated factors in patients with systemic lupus erythematosus (SLE). Patients and methods: In this cross-sectional study, all patients were from a tertiary general hospital between July and October 2016 in Southwest China. The self-care agency was assessed using the Exercise of Self-care Agency Scale. Other variables were measured by the Visual Analog Scale, Systemic Lupus Erythematosus Disease Activity Index 2000, the physical component summary, and mental component summary of the 36-item Short Form Health Survey...
2018: Patient Preference and Adherence
Kristina F Simacek, Tanya Nelson, Mignon Miller-Baldi, Susan C Bolge
Background: As patients are the ultimate stakeholder in their health, their perspectives should be included along with researchers, providers, and funders of research design, execution, and interpretation. Despite the high prevalence of type 2 diabetes mellitus (T2DM), patients are rarely directly included in these decisions. Purpose: We sought to determine areas of research most important to patients with T2DM, identify ways through which patients with T2DM want to engage in research, and evaluate online patient research networks as a source for obtaining patient perspectives on research engagement...
2018: Patient Preference and Adherence
Karin Bæk Knudsen, Kirsten Arntz Boisen, Terese Lea Katzenstein, Laust Hvas Mortensen, Tacjana Pressler, Marianne Skov, Mary Jarden
Background: Cystic fibrosis (CF) is a chronic, life-shortening disease with a significant treatment burden. To support young adults with CF in their everyday life, we previously conducted a life coaching feasibility trial (published elsewhere). The aim of the current study was to explore how life coaching was experienced by study participants within the context of their lives with CF. Methods: A qualitative study using individual interviews. Respondents (n=14) were recruited from the intervention group after participation in life coaching...
2018: Patient Preference and Adherence
Marta Dąbrowska-Bender, Grażyna Dykowska, Wioletta Żuk, Magdalena Milewska, Anna Staniszewska
Aim: The aim of the study was the subjective assessment of the quality of life (QoL) of 140 patients treated with dialysis (peritoneal dialysis and hemodialysis). Background: Chronic kidney disease and the methods of its treatment play an important part in shaping the QoL of patients receiving dialysis. As a result, kidney failure causes many limitations in patients' physical, mental, and social activities. Methods: The instrument to measure the QoL was the authors' own questionnaire made on the basis of Kidney Disease and Quality of Life Short Form version 1...
2018: Patient Preference and Adherence
Elena Didenko Pedersen, Egon Stenager, J L Vadgaard, M B Jensen, R Schmid, N Meland, G Magnussen, Jette L Frederiksen
Background: Disease modifying drugs help control the course of relapsing remitting multiple sclerosis (RRMS); however, good adherence is needed for long-term outcomes. Objective: To evaluate patient adherence to treatment with subcutaneous interferon beta-1a using RebiSmart® and assess injection-site reactions and treatment satisfaction. Methods: This prospective, single-arm, open-label, noninterventional multicenter Phase IV trial included disease modifying drug-experienced mobile patients with RRMS...
2018: Patient Preference and Adherence
Syed Maaz Tariq, Mohammad Hasan, Syed Ali Haider
No abstract text is available yet for this article.
2018: Patient Preference and Adherence
Hai-Lin Ruan, Wen-Han Ge, Jian-Ping Chen, Yuan-Qun Zhu, Wei Huang
Objective: To evaluate the prognostic value of the Prehospital Index (PHI) for hospitalized patients with acute trauma. Materials and methods: PHI score and the Injury Severity Score (ISS) were determined in 1,802 hospitalized patients with acute trauma. Receiver-operator characteristic (ROC) curves were used to compare the PHI and ISS in subgroups, and corresponding prediction indicators were calculated. Results: There were significant differences in PHI score and ISS between the survival group and the death group ( Z =2...
2018: Patient Preference and Adherence
Yaelim Lee
Background: Vaginal dilator (VD) therapy is often recommended for women receiving pelvic radiation therapy or experiencing pain and discomfort during intercourse, as well as for women with a congenital malformation of the vagina. VD use has both physical and psychological benefits; however, it often causes pain, discomfort, and adverse emotions, including embarrassment and loss of modesty, which often result in low adherence to therapy. Objectives: The aims of this study were to explore the use and adherence of VD therapy in women, identify barriers and facilitators of therapy adherence, and suggest improvement strategies from the theoretical perspective of symbolic interactionism...
2018: Patient Preference and Adherence
Alexandra Lucia Vigu, Dorin Stanciu, Lucia Maria Lotrean, Radu Septimiu Campian
Purpose: The purpose of this study was to develop and test a moderated mediation model that was able to describe the relationships between oral health-related attitudes and behaviors, oral health status (OHS), and oral health-related quality of life. The hypothesized relations corresponded to research questions such as "is a person's oral health predicted by the actions that person takes in order to prevent oral health conditions?" and "do individuals with better oral health also have higher levels of oral health-related quality of life?"...
2018: Patient Preference and Adherence
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