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Gastroenterology Research and Practice

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https://www.readbyqxmd.com/read/28210270/face-to-face-cognitive-behavioral-therapy-for-irritable-bowel-syndrome-the-effects-on-gastrointestinal-and-psychiatric-symptoms
#1
Hanna Edebol-Carlman, Brjánn Ljótsson, Steven J Linton, Katja Boersma, Martien Schrooten, Dirk Repsilber, Robert J Brummer
Irritable bowel syndrome (IBS) is a gastrointestinal disorder linked to disturbances in the gut-brain axis. Visceral hypersensitivity and pain are hallmarks of IBS and linked to the physiological and psychological burden and to the nonadaptive coping with stress. Cognitive-behavioral therapy (CBT) for IBS has proven effective in reducing gastrointestinal and psychiatric symptoms in IBS by means of coping with stress. The present pilot study evaluated for the first time whether CBT for IBS affected visceral sensitivity and pain...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28210269/low-prevalence-of-clinically-significant-endoscopic-findings-in-outpatients-with-dyspepsia
#2
Khaled Abdeljawad, Antonios Wehbeh, Emad Qayed
Background. The value of endoscopy in dyspeptic patients is questionable. Aims. To examine the prevalence of significant endoscopic findings (SEFs) and the utility of alarm features and age in predicting SEFs in outpatients with dyspepsia. Methods. A retrospective analysis of outpatient adults who had endoscopy for dyspepsia. Demographic variables, alarm features, and endoscopic findings were recorded. We defined SEFs as peptic ulcer disease, erosive esophagitis, malignancy, stricture, or findings requiring specific therapy...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28210268/protective-effect-of-daikenchuto-on-dextran-sulfate-sodium-induced-colitis-in-mice
#3
Takaharu Matsunaga, Shinichi Hashimoto, Naoki Yamamoto, Ryo Kawasato, Tomohiro Shirasawa, Atsushi Goto, Koichi Fujisawa, Taro Takami, Takeshi Okamoto, Jun Nishikawa, Isao Sakaida
Aim. To investigate the effect of daikenchuto (TJ-100; DKT) for ulcerative colitis (UC) model mouse and assess its anti-inflammatory mechanisms. Methods. We evaluated the effects of DKT on dextran sulfate sodium- (DSS-) induced experimental colitis. First, we assessed the short-term effects of DKT using two groups: 5% DSS group and 5% DSS with DKT group. Colon length; histological scores; and interleukin- (IL-) 10, IL-1β, and tumor necrosis factor-α mRNA expression profiles were analyzed using real-time PCR...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28197206/survival-after-abdominoperineal-and-sphincter-preserving-resection-in-nonmetastatic-rectal-cancer-a-population-based-time-trend-and-propensity-score-matched-seer-analysis
#4
Rene Warschkow, Sabrina M Ebinger, Walter Brunner, Bruno M Schmied, Lukas Marti
Background. Abdominoperineal resection (APR) has been associated with impaired survival in nonmetastatic rectal cancer patients. It is unclear whether this adverse outcome is due to the surgical procedure itself or is a consequence of tumor-related characteristics. Study Design. Patients were identified from the Surveillance, Epidemiology, and End Results database. The impact of APR compared to coloanal anastomosis (CAA) on survival was assessed by Cox regression and propensity-score matching. Results. In 36,488 patients with rectal cancer resection, the APR rate declined from 31...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28197205/from-pathogenesis-clinical-manifestation-and-diagnosis-to-treatment-an-overview-on-autoimmune-pancreatitis
#5
REVIEW
Ou Cai, Shiyun Tan
Autoimmune pancreatitis (AIP) is a special type of chronic pancreatitis which is autoimmune mediated. The international consensus diagnostic criteria (ICDC) 2011 proposed two types of AIP: type I is associated with histological pattern of lymphoplasmacytic sclerosing pancreatitis (LPSP), characterized by serum IgG4 elevation, whereas type 2 is named idiopathic duct-centric pancreatitis (IDCP), with granulocytic epithelial lesion (GEL) and immunoglobulin G4 (IgG4) negative. The pathogenic mechanism is unclear now; based on genetic factors, disease specific or related antigens, innate and adaptive immunity may be involved...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28197204/effects-of-combined-simultaneous-and-sequential-endostar-and-cisplatin-treatment-in-a-mice-model-of-gastric-cancer-peritoneal-metastases
#6
Lin Jia, Shuguang Ren, Tao Li, Jianing Wu, Xinliang Zhou, Yan Zhang, Jianhua Wu, Wei Liu
Objective. Aimed to study the effects of endostar and cisplatin using an in vivo imaging system (IVIS) in a model of peritoneal metastasis of gastric cancer. Methods. NUGC-4 gastric cancer cells transfected with luciferase gene (NUGC-4-Luc) were injected i.p. into nude mice. One week later, mice were randomly injected i.p.: group 1, cisplatin (d1-3) + endostar (d4-7); group 2, endostar (d1-4) + cisplatin (d5-7); group 3, endostar + cisplatin d1, 4, and 7; group 4, saline for two weeks. One week after the final administration, mice were sacrificed...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28194178/role-of-helicobacter-pylori-eradication-therapy-on-platelet-recovery-in-chronic-immune-thrombocytopenic-purpura
#7
Khan Sheema, Ujjan Ikramdin, Naz Arshi, Naz Farah, Sheikh Imran
Background. Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys native platelets. In this condition an autoantibody is generated against a platelet antigen. ITP affects women more often than men and is more common in children than adults. Objective. To assess the effect of Helicobacter pylori eradication therapy (HPET) on platelet count in Helicobacter pylori associated chronic immune thrombocytopenic purpura (chronic ITP) in adult. Materials and Methods. It is an interventional prospective study conducted at Liaquat University of Medical and Health Sciences, Jamshoro, from 2014 to 2015...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28194177/fatty-liver-index-and-lipid-accumulation-product-can-predict-metabolic-syndrome-in-subjects-without-fatty-liver-disease
#8
Yuan-Lung Cheng, Yuan-Jen Wang, Keng-Hsin Lan, Teh-Ia Huo, Yi-Hsiang Huang, Chien-Wei Su, Wei-Yao Hsieh, Ming-Chih Hou, Han-Chieh Lin, Fa-Yauh Lee, Jaw-Ching Wu, Shou-Dong Lee
Background. Fatty liver index (FLI) and lipid accumulation product (LAP) are indexes originally designed to assess the risk of fatty liver and cardiovascular disease, respectively. Both indexes have been proven to be reliable markers of subsequent metabolic syndrome; however, their ability to predict metabolic syndrome in subjects without fatty liver disease has not been clarified. Methods. We enrolled consecutive subjects who received health check-up services at Taipei Veterans General Hospital from 2002 to 2009...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28194176/clinicopathological-features-and-prognostic-factors-of-colorectal-neuroendocrine-neoplasms
#9
Mengjie Jiang, Yinuo Tan, Xiaofen Li, Jianfei Fu, Hanguang Hu, Xianyun Ye, Ying Cao, Jinghong Xu, Ying Yuan
Background. Limited research is available regarding colorectal NENs and the prognostic factors remain controversial. Materials and Methods. A total of 68 patients with colorectal NENs were studied retrospectively. Clinical characteristics and prognosis between colonic and rectal NENs were compared. The Cox regression models were used to evaluate the predictive capacity. Results. Of the 68 colorectal NENs patients, 43 (63.2%) had rectal NENs, and 25 (36.8%) had colonic NENs. Compared with rectal NENs, colonic NENs more frequently exhibited larger tumor size (P < 0...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28191014/extrahepatic-autoimmune-diseases-in-patients-with-autoimmune-liver-diseases-a-phenomenon-neglected-by-gastroenterologists
#10
REVIEW
Liping Guo, Lu Zhou, Na Zhang, Baoru Deng, Bangmao Wang
Autoimmune liver diseases (AILDs) often coexist with other extrahepatic autoimmune diseases (EHAIDs). The spectrum of EHAIDs in patients with AILDs is similar, whereas the incidence is different. Notably, autoimmune thyroid disease and Sjogren's syndrome are the most common EHAIDs. Associated extrahepatic diseases may predate the appearance of AILDs or coincide with their onset. More frequently, they may appear during the course and even occur years after the diagnosis of AILDs. Importantly, associated EHAIDs may influence the natural course and prognosis of AILDs...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28182096/veronicastrum-axillare-alleviates-ethanol-induced-injury-on-gastric-epithelial-cells-via-downregulation-of-the-nf-kb-signaling-pathway
#11
Wei-Chun Zhao, Yan-Shan Xu, Gang Chen, Yan Guo, Dan-Yi Wang, Gui-Bin Meng
We used human gastric epithelial cells (GES-1) line in an ethanol-induced cell damage model to study the protective effect of Veronicastrum axillare and its modulation to NF-κB signal pathway. The goal was to probe the molecular mechanism of V. axillare decoction in the prevention of gastric ulcer and therefore provide guidance in the clinical application of V. axillare on treating injuries from chronic nephritis, pleural effusion, gastric ulcer, and other ailments. The effects of V. axillare-loaded serums on cell viability were detected by MTT assays...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28167959/chemotherapy-plus-cetuximab-versus-chemotherapy-alone-for-patients-with-kras-wild-type-unresectable-liver-confined-metastases-colorectal-cancer-an-updated-meta-analysis-of-rcts
#12
REVIEW
W Lv, G Q Zhang, A Jiao, B C Zhao, Y Shi, B M Chen, J L Zhang
Purpose. Our study analyses clinical trials and evaluates the efficacy of adding cetuximab in systematic chemotherapy for unresectable colorectal cancer liver-confined metastases patients. Materials and Methods. Search EMBASE, PubMed, and the Cochrane Central Register of Controlled Trials for RCTs comparing chemotherapy plus cetuximab with chemotherapy alone for KRAS wild type patients with colorectal cancer liver metastases (CRLMs). We calculated the relative risks (RRs) with 95% confidence interval and performed meta-analysis of hazard ratios (HRs) for the R0 resection rate, the overall response rate (ORR), the progression-free survival (PFS) and overall survival (OS)...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28167958/association-of-fucosyltransferase-2-gene-polymorphisms-with-inflammatory-bowel-disease-in-patients-from-southeast-china
#13
Hao Wu, Liang Sun, Dao-Po Lin, Xiao-Xiao Shao, Sheng-Long Xia, Ming Lv
Aims. Fucosyltransferase 2 (FUT2) gene potentially affects the constituent of intestinal microbiota, which play a crucial role in the pathogenesis of inflammatory bowel disease (IBD). This study investigated the association of FUT2 gene polymorphisms with IBD in southeast China. Methods. We collected 671 IBD patients and 502 healthy controls. FUT2 gene polymorphisms (C357T, A385T, and G428A) were determined by SNaPshot. Frequencies of the FUT2 genotypes, alleles, and haplotype between groups were compared by χ(2) test...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28163717/four-major-factors-contributing-to-intrahepatic-stones
#14
REVIEW
Xi Ran, Baobing Yin, Baojin Ma
Intrahepatic stone is prevalent in Asian countries; though the incidence declines in recent years, the number of patients is still in a large quantity. Because of multiple complications, high recurrence rates, serious systemic damage, and a lack of extremely effective procedure for the management, it is more important to find out the etiology and pathogenesis of intrahepatic stones to prevent the disease from happening and developing rather than curing. A number of factors contribute to the development of the disease, such as cholestasis, infection, and anatomic abnormity of bile duct and bile metabolic defect...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28163716/billroth-ii-with-braun-enteroenterostomy-is-a-good-alternative-reconstruction-to-roux-en-y-gastrojejunostomy-in-laparoscopic-distal-gastrectomy
#15
Long-Hai Cui, Sang-Yong Son, Ho-Jung Shin, Cheulsu Byun, Hoon Hur, Sang-Uk Han, Yong Kwan Cho
Background. Although Billroth II (BII) reconstruction is simpler and faster than Billroth I or Roux-en-Y (RY) reconstruction in patients undergoing totally laparoscopic distal gastrectomy (TLDG), BII reconstruction is associated with several complications, including more severe bile reflux. BII Braun anastomosis may be a better alternative to RY reconstruction. Methods. This retrospective study included 56 consecutive patients who underwent TLDG for gastric cancer, followed by BII Braun or RY reconstruction, between January 2013 and December 2015...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28163715/primary-care-provider-perceptions-of-colorectal-cancer-screening-barriers-implications-for-designing-quality-improvement-interventions
#16
Jennifer M Weiss, Perry J Pickhardt, Jessica R Schumacher, Aaron Potvien, David H Kim, Patrick R Pfau, Elizabeth A Jacobs, Maureen A Smith
Aims. Colorectal cancer (CRC) screening is underutilized. Increasing CRC screening rates requires interventions targeting multiple barriers at each level of the healthcare organization (patient, provider, and system). We examined groups of primary care providers (PCPs) based on perceptions of screening barriers and the relationship to CRC screening rates to inform approaches for conducting barrier assessments prior to designing and implementing quality improvement interventions. Methods. We conducted a retrospective cohort study linking EHR and survey data...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28133480/manometric-measurement-of-the-sphincter-of-oddi-in-patients-with-common-bile-duct-stones-a-consecutive-study-of-the-han-population-of-china
#17
Yadong Feng, Jie Zhang, Chunhua Jiao, Hong Zhu, Wenfang Cheng, Shunfu Xu, Bin Xiao, Jinliang Ni, Xiaoxing Chen
Objective. Role of dysfunction of the sphincter of Oddi (SO) in choledocholithiasis is controversial. This study was to evaluate SO motor activity in patients with common bile duct (CBD) stones in the Han population of China. Patients and Methods. In this study, 76 patients with CBD stones were enrolled in a single tertiary endoscopy center. Data of SO motor activities was prospectively evaluated by endoscopic manometry. Mean basal SO pressure, amplitude, and frequency were collected and analyzed. Results. The mean basal SO pressure, amplitude, and frequency were 52...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28133479/metformin-and-diammonium-glycyrrhizinate-enteric-coated-capsule-versus-metformin-alone-versus-diammonium-glycyrrhizinate-enteric-coated-capsule-alone-in-patients-with-nonalcoholic-fatty-liver-disease-and-type-2-diabetes-mellitus
#18
Rong Zhang, Keran Cheng, Shizan Xu, Sainan Li, Yuqing Zhou, Shunfeng Zhou, Rui Kong, Linqiang Li, Jingjing Li, Jiao Feng, Liwei Wu, Tong Liu, Yujing Xia, Jie Lu, Chuanyong Guo, Yingqun Zhou
Objective. The present study was conducted to compare the efficacy of metformin combined with diammonium glycyrrhizinate enteric-coated capsule (DGEC) versus metformin alone versus DGEC alone for the treatment of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Subjects and Methods. 163 patients with NAFLD and T2DM were enrolled in this 24-week study and were randomized to one of three groups: group 1 was treated with metformin alone; group 2 was treated with DGEC alone; group 3 received metformin plus DGEC combination therapy...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28133478/is-month-of-birth-a-risk-factor-for-colorectal-cancer
#19
N K Francis, N J Curtis, E Noble, M Cortina-Borja, E Salib
Introduction. The developmental origins of health and disease hypothesis and season of birth have been linked to a wide variety of later life conditions including cancer. Whether any relationship between month and season of birth and colorectal cancer exists is unknown. Methods. A case-control study was performed with month of birth extracted from a dedicated colorectal cancer database. Age and gender matched patients were used as a control group. Generalised linear models were fitted with Poisson and negative binomial responses and logarithmic links...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28133477/early-diagnosis-of-helicobacter-pylori-infection-in-vietnamese-patients-with-acute-peptic-ulcer-bleeding-a-prospective-study
#20
Duc Trong Quach, Mai Ngoc Luu, Toru Hiyama, Thuy-HuongThi To, Quy Nhuan Bui, Tuan Anh Tran, Binh Duy Tran, Minh-Cong Hong Vo, Shinji Tanaka, Naomi Uemura
Aims. To investigate H. pylori infection rate and evaluate a combined set of tests for H. pylori diagnosis in Vietnamese patients with acute peptic ulcer bleeding (PUD). Methods. Consecutive patients with acute PUB were enrolled prospectively. Rapid urease test (RUT) with 3 biopsies was carried out randomly. Patients without RUT or with negative RUT received urea breath test (UBT) and serological and urinary H. pylori antibody tests. H. pylori was considered positive if RUT or any noninvasive test was positive...
2017: Gastroenterology Research and Practice
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