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Gastroenterology Research and Practice

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https://www.readbyqxmd.com/read/28928769/exclusive-enteral-nutrition-versus-infliximab-in-inducing-therapy-of-pediatric-crohn-s-disease
#1
Youyou Luo, Jindan Yu, Jingan Lou, Youhong Fang, Jie Chen
AIM: To compare the effectiveness of exclusive enteral nutrition (EEN) and infliximab (IFX) therapy in pediatric Crohn's disease (CD). METHODS: In a prospective study of children initiating EEN or infliximab therapy for CD, we compared clinical outcomes using the pediatric Crohn's disease activity index (PCDAI), growth improvement, endoscopic mucosal healing, and adverse effects. Data were measured at baseline and after 8 weeks of therapy. RESULTS: We enrolled 26 children with CD; of whom, 13 were treated with infliximab, 13 with EEN...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28928768/the-effectiveness-of-personalized-bowel-preparation-using-a-smartphone-camera-application-a-randomized-pilot-study
#2
Jae Won Jung, Jongha Park, Gi Jung Jeon, Young Soo Moon, Sung Yuon Yang, Tae Oh Kim, Eui Tay Jung, Hee-Cheol Kim
BACKGROUND: We aimed to investigate the effectiveness of a smartphone application that analyzes and judges the optimal dosage of polyethylene glycol (PEG) for bowel preparation. METHODS: Patients were assigned to use the smartphone camera application (app group) or written instructions (non-app group). The smartphone camera application was programmed to analyze the bowel preparation quality and automatically determine the dosage of PEG from an analysis of stool images...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28912807/a-meta-analysis-and-systematic-review-of-the-efficacy-of-twice-daily-ppis-versus-once-daily-for-treatment-of-gastroesophageal-reflux-disease
#3
REVIEW
Hongying Zhang, Zhiping Yang, Zhen Ni, Yongquan Shi
BACKGROUND: To investigate whether PPIs BID is superior to QD for treatment of GERD in a short time. METHODS: We searched PubMed, Cochrane Library, Scopus, EMBASE, Ovid, EBSCO, and Web of Science databases (from 1998 to May 2016) to select RCTs, which compared the efficacy of PPIs BID versus QD for GERD. The primary outcomes were symptom relief or esophageal mucosal healing at weeks 4 and 8. The M-H method with fixed-effect or random-effect model was used to calculate RR and 95% CIs...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28912806/associations-of-fatty-liver-disease-with-hypertension-diabetes-and-dyslipidemia-comparison-between-alcoholic-and-nonalcoholic-steatohepatitis
#4
Nobuyuki Toshikuni, Mutsumi Tsuchishima, Atsushi Fukumura, Tomiyasu Arisawa, Mikihiro Tsutsumi
Alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH) are representative types of fatty liver disease (FLD) and have similar histologic features. In this study, we aimed to compare the associations of the two FLD types with hypertension (HT), diabetes mellitus (DM), and dyslipidemia (DL). A nationwide survey investigating FLD status included 753 Japanese subjects (median age 55 years; male 440, female 313) with biopsy-proven ASH (n = 172) or NASH (n = 581). We performed a multiple logistic regression analysis to identify the factors associated with HT, DM, or DL...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28912805/antifibrotic-effect-of-lactulose-on-a-methotrexate-induced-liver-injury-model
#5
Banu Taskin, Mümin Alper Erdoğan, Gürkan Yiğittürk, Damla Günenç, Oytun Erbaş
The most severe side effect of prolonged MTX treatment is hepatotoxicity. The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model. Twenty-four male rats were included in the study. Sixteen rats were given a single dose of 20 mg/kg MTX to induce liver injury. Eight rats were given no drugs. 16 MTX-given rats were divided into two equal groups. Group 1 subjects were given lactulose 5 g/kg/day, and group 2 subjects were given saline 1 ml/kg/day for 10 days...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28912804/assessment-of-nutritional-status-digestion-and-absorption-and-quality-of-life-in-patients-with-locally-advanced-pancreatic-cancer
#6
J E Witvliet-van Nierop, C M Lochtenberg-Potjes, N J Wierdsma, H J Scheffer, G Kazemier, K Ottens-Oussoren, M R Meijerink, M A E de van der Schueren
BACKGROUND AND AIM: To provide a comprehensive quantitative assessment of nutritional status, digestion and absorption, and quality of life (QoL) in patients with locally advanced pancreatic cancer (LAPC). METHODS: Sixteen patients with LAPC were prospectively assessed for weight loss (WL), body mass index (BMI), fat-free mass index (FFMI), handgrip strength (HGS), dietary macronutrient intake, serum vitamin levels, resting and total energy expenditure (REE and TEE, indirect calorimetry), intestinal absorption capacity and fecal losses (bomb calorimetry), exocrine pancreatic function (fecal elastase-1 (FE1)), and gastrointestinal quality of life (GIQLI)...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28900442/impact-of-preoperative-three-dimensional-computed-tomography-cholangiography-on-postoperative-resection-margin-status-in-patients-operated-due-to-hilar-cholangiocarcinoma
#7
A Andert, P Bruners, C Heidenhain, F Ulmer, C D Klink, P H Alizai, C Kuhl, U P Neumann, M Binnebösel
INTRODUCTION: The purpose of this study was to analyse the value of 3-dimensional computed tomography cholangiography (3D-ERC) compared to conventional retrograde cholangiography in the preoperative diagnosis of hilar cholangiocarcinoma (HC) with special regard to the resection margin status (R0/R1). PATIENTS AND METHODS: All hepatic resections performed between January 2011 and November 2013 in patients with HC at the Department of General, Visceral and Transplant Surgery of the RWTH Aachen University Hospital were analysed...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28894466/clinical-factors-of-delayed-perforation-after-endoscopic-submucosal-dissection-for-gastric-neoplasms
#8
Yoshinobu Yamamoto, Hogara Nishisaki, Hideki Sakai, Nagahiro Tokuyama, Hiroaki Sawai, Aya Sakai, Takuya Mimura, Saeko Kushida, Hidetaka Tsumura, Takeshi Sakamoto, Ikuya Miki, Masahiro Tsuda, Hideto Inokuchi
BACKGROUND: Delayed perforation is a rare but severe complication of endoscopic submucosal dissection (ESD) for early gastric neoplasm (EGN). The aim of this study was to clarify clinical factors related to delayed perforation after ESD. METHODS: A total of 1158 consecutive patients with 1199 EGNs underwent ESD at our hospital between January 2000 and December 2015. Univariate analysis was used to identify clinicopathological factors related to delayed perforation...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28894465/a-comprehensive-review-of-bioelectrical-impedance-analysis-and-other-methods-in-the-assessment-of-nutritional-status-in-patients-with-liver-cirrhosis
#9
REVIEW
Halina Cichoż-Lach, Agata Michalak
It is assumed that approximately 24-66% of patients with liver cirrhosis develop malnutrition. Numerous pathological processes lead to serious disorders of nutritional status in this group of patients. Malnutrition in the course of liver cirrhosis is associated with increased morbidity, complications, and low quality of life. Under these conditions, detection of malnutrition is of crucial importance. This review explores the complex mechanisms that lead to malnutrition in the course of liver cirrhosis and focuses on methods used in the assessment of nutritional status in cirrhotic patients...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28894464/inflammatory-markers-as-prognostic-factors-of-survival-in-patients-affected-by-hepatocellular-carcinoma-undergoing-transarterial-chemoembolization
#10
A Rebonato, L Graziosi, D Maiettini, E Marino, V De Angelis, L Brunese, S Mosca, G Metro, M Rossi, G Orgera, M Scialpi, A Donini
INTRODUCTION: Transarterial chemoembolization (TACE) is a good choice for hepatocellular carcinoma (HCC) treatment when surgery and liver transplantation are not feasible. Few studies reported the value of prognostic factors influencing survival after chemoembolization. In this study, we evaluated whether preoperative inflammatory factors such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio affected our patient survival when affected by hepatocellular carcinoma. METHODS: We retrospectively evaluated a total of 72 patients with hepatocellular carcinoma that underwent TACE...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28883831/helicobacter-pylori-infection-is-associated-with-type-2-diabetes-not-type-1-diabetes-an-updated-meta-analysis
#11
REVIEW
Jun-Zhen Li, Jie-Yao Li, Ting-Feng Wu, Ji-Hao Xu, Can-Ze Huang, Di Cheng, Qi-Kui Chen, Tao Yu
BACKGROUND: Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. METHODS: A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28855918/effects-of-a-long-acting-formulation-of-octreotide-on-patients-with-portal-hypertension
#12
Pei-Jing Cui, Jing Yao, Yin Zhu, Zheng-Yun Zhang, Jun Yang
OBJECTIVE: This study aimed to determine whether the treatment of a long-acting formulation of octreotide (OCT-LAR) exerted a similar effect on improving the prognosis of patients with portal hypertension compared with placement of transjugular intrahepatic portosystemic shunts (TIPSs). METHODS: A total of 24 patients with portal hypertension who underwent TIPS placement or OCT-LAR treatment from January 2010 to January 2015 were reviewed. Hemodynamic studies, biological values, live functions, and treatment complications before and during the treatment were evaluated...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28848602/factors-predicting-the-adherence-to-the-therapy-of-italian-ibd-patients
#13
Cristina Bucci, Fabiana Zingone, Stella Tammaro, Paola Iovino, Antonella Santonicola, Carolina Ciacci
BACKGROUND: Inflammatory bowel diseases (IBD) are chronic gastrointestinal disorders influencing many aspects of the patient's life and accounting for substantial social costs. They require long-term therapies and regular contact with the clinic of reference. Our aim is to investigate therapy adherence and identify predictors of adherence. METHODS: 151 patients were recruited in IBD clinic at the University of Salerno filled in the modified Morisky Medication Adherence Scale, a standardized questionnaire provided during the visit...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28835751/radiofrequency-ablation-for-treatment-of-refractory-gastric-antral-vascular-ectasia-a-systematic-review-of-the-literature
#14
REVIEW
M Maida, S Camilleri, M Manganaro, S Garufi, G Scarpulla
BACKGROUND AND STUDY AIMS: GAVE is an uncommon cause of upper nonvariceal bleeding and often manifests itself as occult bleeding with chronic anemia. To date, the standard of care for GAVE is endoscopic treatment with thermoablative techniques. Despite good technical results, approximately two thirds of patients remain dependent on transfusions after the therapy. One of the emerging and more promising endoscopic treatments for GAVE is radiofrequency ablation (RFA). The aim of this study is to perform a systematic review of literature in order to assess current evidence supporting the effectiveness of this technique for treatment of refractory GAVE...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28835750/adjuvant-second-dose-chemotherapy-before-surgery-for-patients-with-locally-advanced-rectal-malignancy-is-not-beneficial-a-systematic-review-and-meta-analysis
#15
REVIEW
Min Chen, Xue Song, Liang-Zhou Chen, Lin Xu, Yi-Pu Lu, Jin-Song Zhang
BACKGROUND: Preoperative chemoradiotherapy is the standard treatment for patients with locally advanced rectal cancer, although tumor responses vary widely; some patients may achieve a pathologic complete response rate (pCR) after chemoradiotherapy. Controversy exists with regard to the efficacy of different preoperative combination chemotherapy regimens and neoadjuvant chemoradiotherapy, compared with chemoradiotherapy alone. METHODS: PubMed, the Cochrane Library, and Embase databases were searched for comparative studies of patients with locally advanced rectal cancer that were published between January 1991 and January 2016...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28831282/gamma-glutamyl-transpeptidase-to-platelet-ratio-predicts-significant-liver-fibrosis-of-chronic-hepatitis-b-patients-in-china
#16
Tianyi Ren, Huan Wang, Ruihong Wu, Junqi Niu
BACKGROUND AND AIMS: We want to investigate whether a novel noninvasive marker is suitable for Chinese CHB patients. METHODS: A total of 160 treatment-naïve CHB patients who underwent liver biopsy were enrolled in our study, and we assessed the diagnostic accuracies of GPR, aspartate transaminase-to-platelet ratio index (APRI), and the fibrosis index based on 4 factors (FIB-4) in them. RESULTS: Of these 160 CHB patients, the numbers of F0, F1, F2, F3, and F4 are 34 (21...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28828004/feasibility-of-short-period-high-dose-intravenous-methylprednisolone-for-preventing-stricture-after-endoscopic-submucosal-dissection-for-esophageal-cancer-a-preliminary-study
#17
Jun Nakamura, Takuto Hikichi, Ko Watanabe, Masaki Sato, Katsutoshi Obara, Hiromasa Ohira
OBJECTIVE: A wide mucosal defect after endoscopic submucosal dissection (ESD) for esophageal cancer is associated with increased risk of stricture. This study was conducted to evaluate the feasibility of short-period, high-dose intravenous methylprednisolone administration (steroid pulse therapy) in preventing post-ESD esophageal stricture. METHODS: This prospective study examined 13 lesions in 11 consecutive patients with esophageal squamous cell carcinoma who underwent ESD that involved three-quarters or more of the circumference of the esophagus or who had a longitudinal resected specimen diameter of ≥5 cm...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28828003/prognostic-value-of-metastatic-tumoral-caveolin-1-expression-in-patients-with-resected-gastric-cancer
#18
Der Sheng Sun, Soon Auck Hong, Hye Sung Won, Su Hyun Yoo, Han Hong Lee, Okran Kim, Yoon Ho Ko
OBJECTIVE: Caveolin-1 (Cav-1), as the main component of caveolae, has complex roles in tumourigenesis in human malignancies. We investigated Cav-1 in primary and metastatic tumor cells of gastric cancer (GC) and its association with clinical outcomes. METHODS: We retrieved 145 cases of GC who had undergone curative gastrectomy. The expression levels of Cav-1 was evaluated by immunohistochemistry, and its association with clinicopathological parameters and patient survival was analyzed...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28819358/surgical-treatment-for-chronic-pancreatitis-past-present-and-future
#19
REVIEW
Stephanie Plagemann, Maria Welte, Jakob R Izbicki, Kai Bachmann
The pancreas was one of the last explored organs in the human body. The first surgical experiences were made before fully understanding the function of the gland. Surgical procedures remained less successful until the discovery of insulin, blood groups, and finally the possibility of blood donation. Throughout the centuries, the surgical approach went from radical resections to minimal resections or only drainage of the gland in comparison to an adequate resection combined with drainage procedures. Today, the well-known and standardized procedures are considered as safe due to the high experience of operating surgeons, the centering of pancreatic surgery in specialized centers, and optimized perioperative treatment...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28819357/the-diagnostic-yield-of-colonoscopy-stratified-by-indications
#20
I Al-Najami, C P Rancinger, Morten Kobaek Larsen, E Spolén, G Baatrup
INTRODUCTION: Danish centers reserve longer time for screening colonoscopies and allocate the most experienced endoscopists to these cases. The objective of this study is to determine the diagnostic yield in colonoscopies for different indications to improve planning of colonoscopy activity and allocation of the highly skilled endoscopists. METHODS: Nine hundred and ninety-nine randomly collected patients from a prospectively maintained database were grouped in defined referral indication groups...
2017: Gastroenterology Research and Practice
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