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Gastroenterology Research and Practice

Ou Cai, Zhenpeng Huang, Ming Li, Chaoqun Zhang, Fengbo Xi, Shiyun Tan
Objective: To investigate the association between Helicobacter pylori ( H. pylori ) infection and nonalcoholic fatty liver disease (NAFLD). Methods: Data from 2051 participants who underwent13 C urea breath test and abdominal ultrasound examinations was collected. Participants were allocated to NAFLD risk group and NAFLD nonrisk group based on definite risk factors for NAFLD. The relationship between H. pylori infection and NAFLD was analyzed. Results: No significant difference was found between rates of H...
2018: Gastroenterology Research and Practice
Changjun Jia, Chaoliu Dai, Hailiang Wang, Yi Wan, Yunyu Qiao, Feng Xu, Songlin Peng, Yang Zhao, Chuang Zhao, Liang Zhao
Background/Aims: Hepatic ischemia-reperfusion (I/R) injury is a serious concern during hepatic vascular occlusion. The objectives of this study were to assess effects of three techniques for hepatic vascular occlusion on I/R injury and to explore the underlying mechanisms. Methods: Liver cirrhotic rats had undertaken Pringle maneuver (PR), hemihepatic vascular occlusion (HH), or hepatic blood inflow occlusion without hemihepatic artery control (WH). Levels of tumor necrosis factor alpha (TNF- α ), nuclear factor kappa B (NF- κ B), toll-like receptor 4 (TLR4), TIR-domain-containing adapter-inducing interferon- β (TRIF), and hemeoxygenase 1 (HMOX1) were assayed...
2018: Gastroenterology Research and Practice
Wei Song, Chuan Tian
Background: Marital status has been reported to be a prognostic factor in multiple malignancies. However, its prognostic value on gastrointestinal stromal tumors (GISTs) have not yet been determined. The objective of the present analysis was to assess the effects of marital status on survival in patients with GISTs. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to analyze 6195 patients who were diagnosed with GISTs from 2001 to 2014...
2018: Gastroenterology Research and Practice
Hang Yin, Lei Wang, Hai-Lin Liu
We investigated in this study the expression of ENO1 in tissues and plasma of PDAC patients to evaluate its clinicopathological and diagnostic significance. ENO1 protein expression was detected in tissue microarray of human PDAC and adjacent noncancer tissues. Electrochemiluminescence immunoassay and amplified luminescent proximity homogeneous assay (AlphaLISA) were performed to measure CA19-9 and ENO1 concentration in plasma from PDAC patients and healthy controls. We demonstrated that ENO1 overexpression is positively correlated with clinical stage, lymph node metastasis, and poor prognosis of PDAC; ENO1 may function as a hopeful candidate diagnostic marker in combination with CA19-9 in PDAC diagnosis...
2018: Gastroenterology Research and Practice
Feiyang Wang, Zibo Meng, Shoukang Li, Yushun Zhang, Heshui Wu
Purpose: The change of serum platelet indices such as platelet distribution width (PDW) has been reported in a series of inflammatory reaction and clinical diseases. However, the relationship between PDW and the incidence of persistent organ failure (POF) in acute pancreatitis (AP) has not been elucidated so far. Materials and Methods: A total of 135 patients with AP admitted within 72 hours from symptom onset of AP at our center between December 2014 and January 2016 were included in this retrospective study...
2017: Gastroenterology Research and Practice
Li Yang, Xiao Wang, Tao Gan, Yiping Wang, Jinlin Yang
Capsule endoscopy has been the first-line examination for small bowel diseases, yet its diagnostic yield is restricted by unsatisfactory bowel preparation. To evaluate the clinical effectiveness of different dosages of polyethylene glycol in patients undergoing capsule endoscopy, we performed a comprehensive meta-analysis of all randomized controlled trials involving polyethylene glycol in preparation for capsule endoscopy. The methodological quality of the trials was evaluated using the Cochrane Risk of Bias assessment instrument...
2017: Gastroenterology Research and Practice
Erika S Boroff, Molly Disbrow, Michael D Crowell, Francisco C Ramirez
Background: Adenoma detection rate (ADR) is a validated quality measure for screening colonoscopy, but there are little data for other indications. The distribution of adenomas is not well described for these indications. Aim: To describe ADR and the adenoma distribution in the proximal and distal colon based on colonoscopy indication. Methods: Outpatient colonoscopies are subdivided by indication. PDR and ADR for the entire colon and for proximal and distal colon...
2017: Gastroenterology Research and Practice
Wenzheng Zhang, Jiang Hu, Bihui Yao, Xvsheng Yang, Lei Song, Ting Yin, Lu Liang
Early and accurate assessment of severity in acute pancreatitis (AP) is of great importance to provide effective disease management and prevent mortality. In this study, we aim to evaluate early indicators that predict the mortality of AP. We retrospectively analyzed 24-hour clinical characteristics and laboratory data in 166 AP patients recruited between January 2014 and November 2015 in Baotou Central Hospital. In total, 18 patients did not survive the disease. Multivariate logistic regression showed that red cell distribution (RDW) (OR = 2...
2017: Gastroenterology Research and Practice
Yakun Wang, Lin Shen, Ming Lu, Zhi Ji, Xiaotian Zhang
Serum α -fetoprotein- (AFP-) elevated gastric cancer is a rare tumor that has a poor prognosis due to high incidence of liver metastasis. This study sought to investigate the optimal treatment modality. A total of 319 gastric cancer patients with liver metastasis (GCLM) whose serum AFP levels were tested before treatment were enrolled in this study. They were classified as the serum AFP ≥ 20 ng/ml group ( n = 74) and the AFP < 20 ng/ml group ( n = 245). Median OS of the AFP < 20 ng/ml group was significantly longer than that of the AFP ≥ 20 ng/ml group (15...
2017: Gastroenterology Research and Practice
Gianni Imperiali, Arnaldo Amato, Maria Maddalena Terpin, Ivo Beverina, Aurora Bortoli, Massimo Devani, Chiara Viganò
Background: Granulocyte-monocyte apheresis has been proposed for the treatment of ulcerative colitis, although it is limited by costs and variability of results. Aim: To assess effectiveness of granulocyte-monocyte apheresis in patients with steroid-dependent, azathioprine-intolerant/resistant moderate ulcerative colitis. Methods: Consecutive patients fulfilling inclusion criteria were prospectively enrolled, treated by apheresis, and followed up for 12 months...
2017: Gastroenterology Research and Practice
Malav P Parikh, Sujit Muthukuru, Yash Jobanputra, Kushal Naha, Niyati M Gupta, Vaibhav Wadhwa, Rocio Lopez, Prashanthi N Thota, Madhusudhan R Sanaka
Background and Aim: Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods: Patients ≥ 50 years of age undergoing a screening colonoscopy between 2012 and 2014 were included. Detection rates based on patient gender, race, colonoscopy timing, fellow participation, bowel preparation quality, and specialty of the endoscopist were calculated...
2017: Gastroenterology Research and Practice
Piyumali Sandareka Arachchi, Neluka Fernando, Manjula Manoji Weerasekera, Bimalka Senevirathna, Deepaka D Weerasekera, Chinthika Prabhashinie Gunasekara
Background: The pro- and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inflammation. Objective: The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF-α) in H. pylori-infected patients and healthy controls and to understand their association with H...
2017: Gastroenterology Research and Practice
Savino Occhionorelli, Monica Zese, Rosario Cultrera, Domenico Lacavalla, Marco Albanese, Giorgio Vasquez
Objective: Laparostomy can be applied in trauma, abdominal sepsis, intra-abdominal hypertension, or compartment syndrome. Systemic infections, especially if complicated by Candida, are associated with a high risk of mortality. Methods: This is a single-centre retrospective case series of 47 cases admitted to our Department, which required laparostomy procedure; we analyzed the type of surgery, temporary abdominal closure, duration of open abdomen, complications, SOFA score, mortality with Candida infections, and empirical or targeted antifungal therapy...
2017: Gastroenterology Research and Practice
Giuseppe Losurdo, Domenico Piscitelli, Federica Pezzuto, Francesco Fortarezza, Claudia Covelli, Antonella Marra, Andrea Iannone, Annacinzia Amoruso, Mariabeatrice Principi, Enzo Ierardi, Alfredo Di Leo
Background and Aims: Nonceliac gluten sensitivity (NCGS) is a gluten-related emerging condition. Since few data about NCGS histopathology is available, we assessed the markers of lymphocyte and innate immunity activation. Materials and Methods: We retrieved duodenal biopsy samples of patients with NCGS diagnosis according to the Salerno criteria. We selected specimens of positive (seropositive celiac disease/Marsh 1-2 stage) and negative (normal microscopic picture) controls...
2017: Gastroenterology Research and Practice
Dae Bum Kim, Woo Chul Chung, Ji Min Lee, Kang-Moon Lee, Jung Hwan Oh, Eun Jung Jeon
Background: The objective of this study was to determine the factors associated with severity of acute pancreatitis (AP) according to two major etiologies: alcohol and gallstones. Methods: We reviewed the medical records of consecutive patients who were admitted with AP between January 2003 and January 2013. A total of 905 patients with AP (660 alcohol-induced, 245 gallstone-induced) were enrolled. Among them, severe AP (SAP) occurred in 72 patients (53 alcohol-induced, 19 gallstone-induced)...
2017: Gastroenterology Research and Practice
Jan de Laffolie, Martin W Laass, Dietmar Scholz, Klaus-Peter Zimmer, Stephan Buderus
Aim: To determine the prevalence of anemia and its association with disease severity in children and adolescents with IBD. Methods: CEDATA-GPGE is a registry for pediatric patients with IBD in Germany and Austria from 90 specialized centers. As markers of disease severity, analysis included patient self-assessment on a Likert scale (1-5; 1 = very good) and physicians' general assessment (0 = no activity to 4 = severe disease) and the disease indices...
2017: Gastroenterology Research and Practice
Lingna Ye, Ziwen Lin, Jing Liu, Qian Cao
Background and Aims: Vitamin D deficiency is common in patients with Crohn's disease and is associated with disease activity. Relationship between vitamin D and endoscopic disease activity is unknown. The aim of the study is to determine the association between vitamin D status and endoscopic disease activity in CD patients. Methods: Consecutive hospitalized CD patients from 2014 to 2016 who received vitamin D assessment and colonoscopy were retrospectively evaluated...
2017: Gastroenterology Research and Practice
Ayse L Mindikoglu, Antone R Opekun, Sood K Gagan, Sridevi Devaraj
Obesity now affects millions of people and places them at risk of developing metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), and even hepatocellular carcinoma. This rapidly emerging epidemic has led to a search for cost-effective methods to prevent the metabolic syndrome and NAFLD as well as the progression of NAFLD to cirrhosis and hepatocellular carcinoma. In murine models, time-restricted feeding resets the hepatic circadian clock and enhances transcription of key metabolic regulators of glucose and lipid homeostasis...
2017: Gastroenterology Research and Practice
Yong Chen, Chao Lian Xie, Ran Hu, Cheng Yi Shen, Mei Zeng, Chang Qiang Wu, Tian Wu Chen, Chen Chen, Meng Yue Tang, Hua Dan Xue, Zheng Yu Jin, Xiao Ming Zhang
Acute pancreatitis (AP) is a complex disease that results in significant morbidity and mortality. For many decades, it has compelled researchers to explore the exact pathogenesis and the understanding of the pathogenesis of AP has progressed dramatically. Currently, premature trypsinogen activation and NF-κB activation for inflammation are two remarkable hypotheses for the mechanism of AP. Meanwhile, understanding of the influence of genetic polymorphisms has resulted in tremendous development in the understanding of the advancement of complex diseases...
2017: Gastroenterology Research and Practice
Hao Zhan, Jiahao Jiang, Qiman Sun, Aiwu Ke, Jinwu Hu, Zhiqiang Hu, Kai Zhu, Chubin Luo, Ning Ren, Jia Fan, Jian Zhou, Xiaowu Huang
Background: Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related mortality in China with increasing incidence. This study is designed to explore early genetic changes implicated in HCC tumorigenesis and progression by whole-exome sequencing. Methods: We firstly sequenced the whole exomes of 5 paired hepatitis B virus-related early-stage HCC and peripheral blood samples, followed by gene ontological analysis and pathway analysis of the single-nucleotide variants discovered...
2017: Gastroenterology Research and Practice
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