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Gastroenterology Research and Practice

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https://www.readbyqxmd.com/read/27891147/effect-of-neoadjuvant-chemoradiotherapy-with-capecitabine-versus-fluorouracil-for-locally-advanced-rectal-cancer-a-meta-analysis
#1
REVIEW
Guo-Chen Liu, Jun-Ping Yan, Qing He, Xin An, Zhi-Zhong Pan, Pei-Rong Ding
A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014. Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion. RevMan software was used to analyze these data...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27885326/review-of-clinical-studies-of-the-treatment-of-ulcerative-colitis-using-acupuncture-and-moxibustion
#2
REVIEW
Jun Ji, Yan Huang, Xia-Fei Wang, Zhe Ma, Huan-Gan Wu, Hyoyoung Im, Hui-Rong Liu, Lu-Yi Wu, Jing Li
Background. Clinical studies suggest that acupuncture and moxibustion therapy in ulcerative colitis (UC) can regulate bowel inflammation, and these treatments have the advantages of low rates of adverse reactions and recurrence as well as good long-term efficacy. We reviewed the current status of clinical studies of the treatment. Methods. Randomized controlled trials (RCTs) using the therapy as the major intervention for treating UC were included from 1995 to 2015. The extracted data mainly included diagnostic standards, treatment methods, selection of acupoints, treatment times and courses, and efficacy determination criteria...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27885325/current-role-of-minimally-invasive-radical-cholecystectomy-for-gallbladder-cancer
#3
REVIEW
Giuseppe Zimmitti, Alberto Manzoni, Francesca Guerini, Marco Ramera, Paola Bertocchi, Francesca Aroldi, Alberto Zaniboni, Edoardo Rosso
Background. For Tis and T1a gallbladder cancer (GbC), laparoscopic cholecystectomy can provide similar survival outcomes compared to open cholecystectomy. However, for patients affected by resectable T1b or more advanced GbC, open approach radical cholecystectomy (RC), consisting in gallbladder liver bed resection or segment 4b-5 bisegmentectomy, with locoregional lymphadenectomy, is considered the gold standard while minimally invasive RC (MiRC) is skeptically considered. Aim. To analyze current literature on perioperative and oncologic outcomes of MiRC for patients affected by GbC...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27882046/the-role-of-genetic-and-immune-factors-for-the-pathogenesis-of-primary-sclerosing-cholangitis-in-childhood
#4
REVIEW
Priscila Menezes Ferri, Ana Cristina Simões E Silva, Soraya Luiza Campos Silva, Diego Junior Queiroga de Aquino, Eleonora Druve Tavares Fagundes, Débora Marques de Miranda, Alexandre Rodrigues Ferreira
Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by chronic inflammation of the biliary tree resulting in liver fibrosis. PSC is more common in male less than 40 years of age. The diagnosis of PSC is based on clinical, laboratory, image, and histological findings. A biochemical profile of mild to severe chronic cholestasis can be observed. Endoscopic retrograde cholangiography is the golden standard method for diagnosis, but magnetic resonance cholangiography is currently also considered a first-line method of investigation...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27882045/comparison-of-bisap-ranson-mctsi-and-apache-ii-in-predicting-severity-and-prognoses-of-hyperlipidemic-acute-pancreatitis-in-chinese-patients
#5
Lixin Yang, Jing Liu, Yun Xing, Lichuan Du, Jing Chen, Xin Liu, Jianyu Hao
In recent years, with the developing of living standard, hyperlipidemia becomes the second major reason of acute pancreatitis. It is important to predict the severity and prognosis at early stage of hyperlipidemic acute pancreatitis (HLAP). We compared the BISAP, Ranson, MCTSI, and APACHE II scoring system in predicting MSAP and SAP, local complications, and mortality of HLAP. A total of 326 diagnosed hyperlipidemic acute pancreatitis patients from August 2006 to July 2015 were studied retrospectively. Our result showed that all four scoring systems can be used to predict the severity, local complications, and mortality of HLAP...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27872640/nucleotide-analogue-related-proximal-renal-tubular-dysfunction-during-long-term-treatment-of-chronic-hepatitis-b-a-cross-sectional-study
#6
Abhasnee Sobhonslidsuk, Jirachaya Wanichanuwat, Pawin Numthavaj, Areepan Sophonsritsuk, Supanna Petraksa, Alongkorn Pugasub, Paisan Jittorntam, Anucha Kongsomgan, Sittiruk Roytrakul, Bunyong Phakdeekitcharoen
Background. There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD. Methods. A cross-sectional study was performed in CHB patients taking nucleotide analogues. Inclusion criteria were patients who were on adefovir or tenofovir as mono- or add-on therapy with lamivudine (LAM) >1 year. Serum and urine were collected. Fractional excretion of phosphate (FEPO4), uric acid (FEUA), and potassium was calculated...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27867394/association-of-tissue-transglutaminase-antibody-titer-with-duodenal-histological-changes-in-children-with-celiac-disease
#7
Hasan Hawamdeh, Basim Al-Zoubi, Yasameen Al Sharqi, Ayman Qasrawi, Yousef Abdelaziz, Maha Barbar
Celiac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy. Celiac specific antibodies are used as an initial screening test. The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with celiac disease. Method. The medical records of 81 children who had elevated anti-tTG titer and had duodenal biopsies available were retrospectively reviewed. Result. Assessing the association of anti-tTG titer with duodenal histopathological changes, 94% of those with high anti-tTG titer (≥180 U/mL) had histological evidence of celiac disease...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27843449/short-term-efficacy-of-laparoscopic-treatment-for-colorectal-cancer-in-patients-with-schistosomiasis-japonica
#8
Zhu Yi, Jiang Hong-Gang, Chen Zhi-Heng, Lu Bo-Hao
Introduction. Schistosomiasis is associated with numerous complications such as thrombocytopenia, liver cirrhosis, portal hypertension, and colitis. To the best of our knowledge, the feasibility and outcomes of laparoscopic colorectal surgery in patients with schistosomiasis have not yet been studied. Methods. In this study, the data of 280 patients with colorectal carcinoma along with schistosomiasis japonica infection who underwent laparoscopic or open colorectal surgery were retrospectively analyzed. Preoperative data, operative data, pathological outcomes, postoperative complications, and recovery were compared between patients in the laparoscopic (LAC) and open (OC) groups...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27843448/could-total-colectomy-with-ileorectal-anastomosis-be-an-alternative-to-total-proctocolectomy-with-ileal-pouch-anal-anastomosis-in-selected-ulcerative-colitis-patients
#9
Francesco Tonelli, Carmela Di Martino, Francesco Giudici
Purpose. To evaluate ileorectal anastomosis (IRA) in selected ulcerative colitis patients. Methods. Early and late complications after IRA and IPAA were investigated. Bowel function and quality of life were assessed. Functional and QoL studies were performed as a matched pair analysis, comparing 98 patients who underwent IRA versus 98 patients who underwent IPAA. Results. In IRA group, 2 patients (1.6%) developed anastomotic l dysplasia (HGD) developed in 3 patients dysplasia (HGD) developed in 3 patients eakage, 1 patient (0...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27840636/the-role-of-h-pylori-caga-in-regulating-hormones-of-functional-dyspepsia-patients
#10
REVIEW
Wang-Ping Meng, Zhong-Qiong Wang, Jia-Qi Deng, Yi Liu, Ming-Ming Deng, Mu-Han Lü
Helicobacter pylori (H. pylori, Hp) colonizes the stomachs of approximately 20%-80% of humans throughout the world. The Word Healthy Organization (WHO) classified H. pylori as a group 1 carcinogenic factor in 1994. Recently, an increasing number of studies has shown an association between H. pylori infection and various extragastric diseases. Functional dyspepsia (FD) is considered a biopsychosocial disorder with multifactorial pathogenesis, and studies have shown that infection with CagA-positive H. pylori strains could explain some of the symptoms of functional dyspepsia...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27840635/phase-i-clinical-research-of-jejunal-interposition-in-adenocarcinoma-of-the-esophagogastric-junction-ii-iii-proximal-gastrectomy
#11
Kai Tao, Jian-Hong Dong
Objective. To investigate the feasibility and specific methods of single-tract jejunal interposition between esophagus and remnant stomach (ers-STJI) in adenocarcinoma of the esophagogastric junction (AEG) II/III proximal gastrectomy. Methods. 15 AEG II/III gastric cancer (GC) patients in phase T1-3N0M0 with tumor size <5 cm were selected and they underwent proximal gastrectomy with ers-STJI from August 2013 to August 2014. Results. All of the 15 patients successfully completed GC R0 proximal gastrectomy with ers-STJI and no operative death or no significant complication occurred; one patient had anastomotic inflammatory granuloma...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27829832/members-of-the-cyr61-ctgf-nov-protein-family-emerging-players-in-hepatic-progenitor-cell-activation-and-intrahepatic-cholangiocarcinoma
#12
Qunfeng Wu, Marda Jorgensen, Joanna Song, Junmei Zhou, Chen Liu, Liya Pi
Hepatic stem/progenitor cells (HPC) reside quiescently in normal biliary trees and are activated in the form of ductular reactions during severe liver damage when the replicative ability of hepatocytes is inhibited. HPC niches are full of profibrotic stimuli favoring scarring and hepatocarcinogenesis. The Cyr61/CTGF/NOV (CCN) protein family consists of six members, CCN1/CYR61, CCN2/CTGF, CCN3/NOV, CCN4/WISP1, CCN5/WISP2, and CCN6/WISP3, which function as extracellular signaling modulators to mediate cell-matrix interaction during angiogenesis, wound healing, fibrosis, and tumorigenesis...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27822226/somatic-comorbidity-in-chronic-constipation-more-data-from-the-gecco-study
#13
Paul Enck, Johannes Leinert, Menno Smid, Thorsten Köhler, Juliane Schwille-Kiuntke
Background. Comorbidity in chronic constipation has rarely been investigated, despite the fact that constipation can occur as one symptom in a number of neurological, systemic, and other nonintestinal and intestinal disorders. Methods. Of 1037 individuals with constipation identified during a telephone survey, 589 returned a postal questionnaire with valid data, asking for sociographic data, clinical symptoms, comorbid conditions, medication intake, and health care behavior related to constipation. Among them, 245 reported some somatic diagnoses and another 120 regular medication intake...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27822225/diagnosis-and-management-of-gastrointestinal-foreign-bodies
#14
EDITORIAL
Kenya Kamimura, David C Evans, Ken-Ichi Mizuno, Juan E Sola
No abstract text is available yet for this article.
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27818681/identification-of-the-key-genes-and-pathways-in-esophageal-carcinoma
#15
Peng Su, Shiwang Wen, Yuefeng Zhang, Yong Li, Yanzhao Xu, Yonggang Zhu, Huilai Lv, Fan Zhang, Mingbo Wang, Ziqiang Tian
Objective. Esophageal carcinoma (EC) is a frequently common malignancy of gastrointestinal cancer in the world. This study aims to screen key genes and pathways in EC and elucidate the mechanism of it. Methods. 5 microarray datasets of EC were downloaded from Gene Expression Omnibus. Differentially expressed genes (DEGs) were screened by bioinformatics analysis. Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and protein-protein interaction (PPI) network construction were performed to obtain the biological roles of DEGs in EC...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27818680/identifying-risk-factors-associated-with-inappropriate-use-of-acid-suppressive-therapy-at-a-community-hospital
#16
Amandeep Singh, Vijay Bodukam, Kirit Saigal, Jaya Bahl, Yvette Wang, Alexandra Hanlon, Yinghui Lu, Michael Davis
Purpose. By examining the prescribing patterns and inappropriate use of acid suppressive therapy (AST) during hospitalization and at discharge we sought to identify the risk factors associated with such practices. Methods. In this retrospective observational study, inpatient records were reviewed from January 2011 to December 2013. Treatment with AST was considered appropriate if the patient had a known specific indication or met criteria for stress ulcer prophylaxis. Results. In 2011, out of 58 patients who were on AST on admission, 32 were newly started on it and 23 (72%) were inappropriate cases...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27818679/prophylactic-mesh-application-during-colostomy-to-prevent-parastomal-hernia-a-meta-analysis
#17
REVIEW
JunJia Zhu, YuWei Pu, XiaoDong Yang, DeBao Zhang, Kui Zhao, Wei Peng, ChunGen Xing
Background. Parastomal hernia is a common complication after stoma formation, especially in permanent colostomy. The present meta-analysis aimed to evaluate the effectiveness of prophylactic mesh application during permanent colostomy for preventing parastomal hernia. Methods. Randomized controlled trials comparing outcomes in patients who underwent colostomy with or without prophylactic mesh application were identified from PubMed, EMBASE, Science Citation Index, and the Cochrane Libraries. Results. This meta-analysis included 8 randomized controlled trials with 522 participants...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27807447/endoscopic-management-of-foreign-bodies-in-the-gastrointestinal-tract-a-review-of-the-literature
#18
REVIEW
Mikhael Bekkerman, Amit H Sachdev, Javier Andrade, Yitzhak Twersky, Shahzad Iqbal
Foreign body ingestion is a common diagnosis that presents in emergency departments throughout the world. Distinct foreign bodies predispose to particular locations of impaction in the gastrointestinal tract, commonly meat boluses in the esophagus above a preexisting esophageal stricture or ring in adults and coins in children. Several other groups are at high risk of foreign body impaction, mentally handicapped individuals or those with psychiatric illness, abusers of drugs or alcohol, and the geriatric population...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27807446/comment-on-lack-of-association-found-between-helicobacter-pylori-infection-and-diarrhea-predominant-irritable-bowel-syndrome-a-multicenter-retrospective-study
#19
COMMENT
Amin Talebi Bezmin Abadi
No abstract text is available yet for this article.
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27799939/analysis-of-predictors-for-lymph-node-metastasis-in-patients-with-superficial-esophageal-carcinoma
#20
Ruzhen Jia, Qinsong Luan, Jing Wang, Dongsheng Hou, Shulei Zhao
In order to predict related risk factors for lymph node metastasis (LNM) in patients with superficial esophageal carcinoma (SEC) and provide reference for endoscopic minimally invasive treatment, we included a total of 93 patients with superficial esophageal carcinoma who have underwent esophagectomy and lymph node dissection from 2010 to 2015. The depth of invasion was remeasured and classified into 6 groups according to their wall penetration. The prediction model was founded based on the independent risk factors...
2016: Gastroenterology Research and Practice
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