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Gastroenterology Research and Practice

Nicolas Tabchouri, David Dussart, Urs Giger-Pabst, Nicolas Michot, Frederic Marques, Meriem Khalfallah, Petru Bucur, Louise Barbier, Aurore Kraemer-Bucur, Mihane Nayeri, Julien Thiery, Celine Bourbao-Tournois, Pascal Bourlier, Ephrem Salamé, Mehdi Ouaïssi
Background: Adhesive small bowel obstruction (SBO) represents a heavy burden in healthcare systems worldwide and is associated with significant morbidity and mortality. Although conservative treatment alone can lead to SBO resolution in most cases, its optimal duration is still a matter of debate. The aim of this study was to analyze different SBO evolution patterns in order to further determine when to switch to surgical treatment. Study Design: All patients who were admitted for adhesive SBO between 2011 and 2016 were reviewed...
2018: Gastroenterology Research and Practice
Laszlo Markasz, Alkwin Wanders, Laszlo Szekely, Helene Engstrand Lilja
Background: Necrotizing enterocolitis (NEC) is the most common gastrointestinal disorder in premature infants with a high morbidity and mortality. Paneth cell dysfunction has been suggested to be involved in the pathogenesis of NEC. Defensin alpha-6 (DEFA6) is a specific marker for Paneth cells acting as part of the innate immunity in the human intestines. The aim of this study was to investigate the expression of DEFA6 in infants with NEC. Materials and Methods: Infants who underwent bowel resection for NEC at level III NICU in Sweden between August 2004 and September 2013 were eligible for the study...
2018: Gastroenterology Research and Practice
Priscilla S P Oliveira, Rita B Carvalho, Daniela O Magro, Michel G Camargo, Carlos A R Martinez, Claudio S R Coy
Background: Serrated colorectal lesions are increasingly recognized as an important process in the development of colorectal cancer. Endoscopic and histological diagnosis may be difficult, and knowledge of the serrated lesions is important for the establishment of strategies for treating colorectal lesions. We aimed to analyze serrated lesions diagnosed at a single center and evaluate if there was an increase in their identification over the years. Design and Setting: A retrospective analysis of colonoscopy reports was performed at a specialized center from 2005 to 2014...
2018: Gastroenterology Research and Practice
Han-Yi Song, Long Zhou, Dong-Yan Liu, Xin-Jie Yao, Yan Li
With the rising global prevalence of antibiotic resistance, the eradication rate of Helicobacter pylori (HP) is continuing to decrease. Probiotics are beneficial to human health and may be an adjunct therapy to increase the eradication rate of HP, lower treatment-associated side effects, and reduce HP-associated gastric inflammation. However, inconsistent test results have prevented conclusions about the therapeutic prowess of probiotics for HP. The mechanisms of actions of probiotics include the production of substances that inhibit or kill HP or compete with HP for the adhesion site on gastric epithelial cells...
2018: Gastroenterology Research and Practice
Mladen Pavlovic, Nevena Gajovic, Milena Jurisevic, Slobodanka Mitrovic, Gordana Radosavljevic, Jelena Pantic, Nebojsa Arsenijevic, Ivan Jovanovic
Introduction: Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers. The aim of the study was to determine the expression of IL-32, proinflammatory and angiogenic mediators, in patients with diffuse and intestinal gastric cancer and the relationship with clinicopathological aspects. Material and Methods: The tissue samples of diffuse and intestinal types of tumor of 70 patients with gastric cancer were analyzed...
2018: Gastroenterology Research and Practice
Bum Jun Kim, Hyeong Su Kim, Hyun Joo Jang, Jung Han Kim
Objective: Several recent reviews of published studies have shown that the eradication of H. pylori infection in patients with ITP improved thrombocytopenia in about half of the cases. However, most included studies were observational case series. We performed the first meta-analysis of randomized trials to gain a better insight into the effect of H. pylori eradication in ITP patients. Methods: A systematic computerized search of the electronic databases including PubMed, EMBASE, Google Scholar, and Cochrane Library (up to December 2017) was conducted...
2018: Gastroenterology Research and Practice
Daniela Pugliese, Annalisa Aratari, Stefano Festa, Pietro Manuel Ferraro, Rita Monterubbianesi, Luisa Guidi, Maria Lia Scribano, Claudio Papi, Alessandro Armuzzi
Background and Aims: Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients. Methods: All UC patients receiving thiopurine monotherapy at three tertiary IBD centers from 1995 to 2015 were identified. The primary endpoint was steroid-free clinical remission...
2018: Gastroenterology Research and Practice
Yi Zang, Lei Zhu, Tong Li, Qi Wang, Juanjuan Li, Yuting Qian, Lumin Wei, Mingping Xie, Wen-Hao Tang, Xu Liu, Ying Zhu, Lifu Wang
The EI24 autophagy-associated transmembrane protein is frequently associated with tumor growth and patient survival. In the present study, we found that EI24 was downregulated in pancreatic ductal adenocarcinoma (PDAC) tissues compared with adjacent normal tissues and was associated with cancer cell differentiation. Overexpression of EI24 suppressed cancer cell growth in vitro and in vivo and induced cell cycle S phase arrest, with no impact on caspase-dependent apoptosis. EI24 overexpression also resulted in reduced c-Myc expression, an oncogene in PDAC, accompanied with increased LC3B-II formation, increased Beclin-1, and diminished p62...
2018: Gastroenterology Research and Practice
Patrick L Stoner, Amir Kamel, Fares Ayoub, Sanda Tan, Atif Iqbal, Sarah C Glover, Ellen M Zimmermann
Patients with inflammatory bowel disease (IBD) commonly require surgery despite the availability of an increasingly large repertoire of powerful immunosuppressive medications for the treatment of IBD. Optimizing patients' care preoperatively is crucial to obtaining good surgical outcomes. This review discusses preoperative assessment and management principles including assessing disease location and activity with cross-sectional or endoscopic imaging, addressing modifiable risk factors (i.e., stopping smoking, weaning steroids, and correcting anemia), and properly managing medications...
2018: Gastroenterology Research and Practice
Eun Young Park, Dong Hoon Baek, Gwang Ha Kim, Bong Eun Lee, So-Jeong Lee, Do Youn Park
Background: Chronic gastric anisakiasis is a rare, usually asymptomatic, and difficult to diagnose infection incidentally discovered during endoscopy, resembling a subepithelial tumor (SET). Because its endoscopic ultrasonography (EUS) findings are not established, it is occasionally misdiagnosed as gastrointestinal mesenchymal tumors and removed by endoscopic or surgical resection. We aimed to assess the characteristic EUS findings of chronic gastric anisakiasis and the clinical course during follow-up...
2018: Gastroenterology Research and Practice
Yuting Qian, Tingting Bai, Juanjuan Li, Yi Zang, Tong Li, Mingping Xie, Qi Wang, Lifu Wang, Ruizhe Shen
Objective: This study aimed at investigating the clinical value of magnetic-guided capsule endoscopy (MGCE) in the diagnosis of gastrointestinal diseases in minors. Methods: Eighty-four minor patients hospitalized in the pediatric department at Ruijin Hospital between June 2015 and January 2018 were enrolled for this study. Following bowel preparation, all patients underwent MGCE. The feasibility, safety, diagnostic yield, and sensitivity of MGCE were analyzed. Patients were followed up for more than 2 weeks...
2018: Gastroenterology Research and Practice
Deepak Agrawal, Rajeev Jain
Background: Endoscopy nurse (RN) has a pivotal role in administration and monitoring of moderate sedation during endoscopic procedures. When sedation for the procedure is administered and monitored by an anesthesia specialist, the role of an RN is less clear. The guidelines on this issue by nursing and gastroenterology societies are contradictory. Methods: Survey study of endoscopy lab managers and directors at outpatient endoscopy units in Texas. The questions related to staffing patterns for outpatient endoscopies and responsibilities of different personnel assisting with endoscopies...
2018: Gastroenterology Research and Practice
Yongke Liu, Dong Guo, Zhaojian Niu, Yuliang Wang, Guanghua Fu, Yanbing Zhou, Qingkai Xue, Xinliang Jin, Zhiqi Gong
Propose: The purpose of this study was to compare the accuracy of visceral fat area (VFA) and body mass index (BMI) in predicting the risk of laparoscopic-assisted gastrectomy. Methods: Clinicopathological and imaging data of 133 patients who underwent laparoscopy-assisted gastrectomy were recorded, including 17 cases of conversion to open surgery. The remaining 116 patients were retrospectively analyzed after we excluded 17 patients who had been transferred to laparotomy...
2018: Gastroenterology Research and Practice
Yong Fei Hua, Dipesh Kumar Yadav, Xueli Bai, Tingbo Liang
Objective: To summarize the operation experience of laparoscopic spleen-preserving distal pancreatectomy (LSPDP) with preservation of splenic vessels by an inferior-posterior dissection of the pancreatic body and evaluate its feasibility. Methods: Patients undergoing LSPDS at Ningbo Li Huili Hospital and Ningbo Li Huili Eastern Hospital from January 2014 to April 2017 were recruited in this study and were analyzed retrospectively. They were divided into two groups based on the surgical approach: the inferior-posterior approach group and the other approach group...
2018: Gastroenterology Research and Practice
Laura Conti, Edith Lahner, Gloria Galli, Gianluca Esposito, Marilia Carabotti, Bruno Annibale
Objectives: Autoimmune diseases (AD) may be associated with coeliac disease (CD), but specific risk factors have been poorly investigated. The aim of this study was to assess the spectrum of AD and its specific risk factors associated in a series of adult coeliac patients. Materials and Methods: We performed a single-center case-control study including adult newly diagnosed CD patients. To evaluate the risk factors of the association between AD and CD, 341 coeliac patients included were categorized on the basis of AD presence: 91 cases with at least one AD and 250 controls without AD were compared for clinical, serological, and histological features...
2018: Gastroenterology Research and Practice
Yi-Bing Hu, En-De Hu, Rong-Quan Fu
Background: Type 2 diabetes mellitus (T2DM) patients are involved closely with cancer. This work aims to conduct a systematic review and network meta-analysis (NMA) to examine the effect of different types of statins on cancer incidence in patients with T2DM. Methods: We systematically searched the Cochrane Library, PubMed, Embase, and Wanfang databases from January 1999 to March 2017. We performed a pairwise meta-analysis to estimate the pooled ratios (ORs) and 95% confidence intervals (CIs)...
2018: Gastroenterology Research and Practice
Evelyn Pedroso Toscano, Fernanda Fernandes Madeira, Mayra Pinheiro Dutra-Rulli, Luiz Otavio Maia Gonçalves, Marcela Alcântara Proença, Viviane Silva Borghi, Aline Cristina Targa Cadamuro, Giselda Warick Mazzale, Ricardo Acayaba, Ana Elizabete Silva
Aim: To evaluate the prevalence and risk factors of H. pylori infection in the pediatric and adult population seen at a public hospital in São José do Rio Preto, SP, Brazil. Methods: This is a retrospective study that evaluated 2406 medical records of children, adolescents, and adults with dyspeptic symptoms who underwent upper gastrointestinal endoscopy. H. pylori diagnosis and demographic and clinical-pathological features were recorded. Results: A total of 852 subjects were H...
2018: Gastroenterology Research and Practice
Xing-Kang He, Wenrui Wu, Yu-E Ding, Yue Li, Lei-Min Sun, Jianmin Si
Background: In terms of incidence and pathogenesis, right-sided colon cancer (RCC) and left-sided colon cancer (LCC) exhibit several differences. However, whether existing differences could reflect the different survival outcomes remains unclear. Therefore, we aimed to ascertain the role of location in the prognosis. Methods: We identified colon cancer cases from the Surveillance, Epidemiology, and End Results database between 1973 and 2012. Differences among subsites of colon cancer regarding clinical features and metastatic patterns were compared...
2018: Gastroenterology Research and Practice
Vinay Sehgal, Avi Rosenfeld, David G Graham, Gideon Lipman, Raf Bisschops, Krish Ragunath, Manuel Rodriguez-Justo, Marco Novelli, Matthew R Banks, Rehan J Haidry, Laurence B Lovat
Introduction: Barrett's oesophagus (BE) is a precursor to oesophageal adenocarcinoma (OAC). Endoscopic surveillance is performed to detect dysplasia arising in BE as it is likely to be amenable to curative treatment. At present, there are no guidelines on who should perform surveillance endoscopy in BE. Machine learning (ML) is a branch of artificial intelligence (AI) that generates simple rules, known as decision trees (DTs). We hypothesised that a DT generated from recognised expert endoscopists could be used to improve dysplasia detection in non-expert endoscopists...
2018: Gastroenterology Research and Practice
Shanglei Ning, Siquan Ma, Abdul Qahar Saleh, Lingyu Guo, Zixiao Zhao, Yuxin Chen
Background and Objective: Serine hydroxymethyltransferase 2 (SHMT2) functions as a key enzyme in serine/glycine biosynthesis and one-carbon metabolism. Recent studies have shown that SHMT2 participated in tumor growth and progression in a variety of cancer types. The objective of the present study is to explore the expression of SHMT2 and evaluate its prognostic value in patients with intrahepatic cholangiocarcinoma (iCCA). Patients and Methods: We retrospectively investigated the expression of SHMT2 in 100 primary iCCA samples through immunohistochemical (IHC) staining on a tissue array...
2018: Gastroenterology Research and Practice
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