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Gastroenterology Research and Practice

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https://www.readbyqxmd.com/read/28337217/cost-effectiveness-analysis-of-helicobacter-pylori-diagnostic-methods-in-patients-with-atrophic-gastritis
#1
Fumio Omata, Takuro Shimbo, Sachiko Ohde, Gautam A Deshpande, Tsuguya Fukui
Background. There are several diagnostic methods for Helicobacter pylori (H. pylori) infection. A cost-effective analysis is needed to decide on the optimal diagnostic method. The aim of this study was to determine a cost-effective diagnostic method in patients with atrophic gastritis (AG). Methods. A decision-analysis model including seven diagnostic methods was constructed for patients with AG diagnosed by esophagogastroduodenoscopy. Expected values of cost and effectiveness were calculated for each test...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28331493/feasibility-and-safety-of-pressurized-intraperitoneal-aerosol-chemotherapy-for-peritoneal-carcinomatosis-a-retrospective-cohort-study
#2
Martin Hübner, Hugo Teixeira Farinha, Fabian Grass, Anita Wolfer, Patrice Mathevet, Dieter Hahnloser, Nicolas Demartines
Background. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been introduced as a novel repeatable treatment for peritoneal carcinomatosis. The available evidence from the pioneer center suggests good tolerance and high response rates, but independent confirmation is needed. A single-center cohort was analyzed one year after implementation for feasibility and safety. Methods. PIPAC was started in January 2015, and every patient was entered into a prospective database. This retrospective analysis included all consecutive patients operated until April 2016 with emphasis on surgical feasibility and early postoperative outcomes...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28331492/correlation-of-body-mass-index-and-waist-hip-ratio-with-severity-and-complications-of-hyperlipidemic-acute-pancreatitis-in-chinese-patients
#3
Lixin Yang, Jing Liu, Yun Xing, Lichuan Du, Jing Chen, Xin Liu, Jianyu Hao
Hyperlipidemic acute pancreatitis (HLAP) is characterized by critical condition and high recurrence rate compared with non-HLAP. We conducted this study to investigate the value of body mass index and waist-hip ratio in predicting severity and local complications in HLAP. 96 patients with HLAP were categorized by body mass index and waist-hip ratio, respectively. According to the body mass index, they were divided into 3 groups, including normal weight, overweight, and obesity. According to the waist-hip ratio, they were divided into central obesity group and no central obesity group...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28331491/tumor-size-is-a-critical-factor-in-adjuvant-chemotherapy-for-t3-4an0m0-gastric-cancer-patients-after-d2-gastrectomy
#4
Shi Chen, Li-Ying Ou-Yang, Run-Cong Nie, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, Ying-Bo Chen, Jun-Sheng Peng
Aim. To investigate whether tumor size is a reasonable indication for adjuvant chemotherapy for T3-4aN0M0 gastric cancer patients after D2 gastrectomy. Method. We performed a retrospective study of 269 patients with a histological diagnosis of T3-4aN0M0 stage gastric cancer who underwent D2 radical surgery at the Sun Yat-sen University Cancer Center or the Sixth Affiliated Hospital of Sun Yat-sen University between January 2006 and December 2010. The follow-up lasted until June of 2015. Chi-square tests and Kaplan-Meier methods were employed to compare the clinicopathological variables and prognoses...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28326100/immunohistochemical-markers-as-predictors-of-histopathologic-response-and-prognosis-in-rectal-cancer-treated-with-preoperative-adjuvant-therapy-state-of-the-art
#5
REVIEW
Alessandro Del Gobbo, Stefano Ferrero
We explain the state of the art of the immunohistochemical markers of response in rectal cancers treated with neoadjuvant medical therapies and its implication with prognosis. Neoadjuvant chemoradiotherapy is widely used to improve the outcome of patients with locally advanced rectal cancer, and the evaluation of the effects of medical therapy is to date based on histomorphological examination by applying four grading systems of response to therapy (tumor regression grade (TRG)). The need to identify immunohistochemical markers that could ensure a better assessment of response and possibly provide additional prognostic information has emerged...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28316623/a-review-of-the-role-of-neurotensin-and-its-receptors-in-colorectal-cancer
#6
REVIEW
Shengyang Qiu, Gianluca Pellino, Francesca Fiorentino, Shahnawaz Rasheed, Ara Darzi, Paris Tekkis, Christos Kontovounisios
Neurotensin (NTS) is a physiologically occurring hormone which affects the function of the gastrointestinal (GI) tract. In recent years, NTS, acting through its cellular receptors (NTSR), has been implicated in the carcinogenesis of several cancers. In colorectal cancer (CRC), a significant body of evidence, from in vitro and in vivo studies, is available which elucidates the molecular biology of NTS/NTSR signalling and the resultant growth of CRC cells. There is growing clinical data from human studies which corroborate the role NTS/NTSR plays in the development of human CRC...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28316622/risk-factors-for-additional-surgery-after-iatrogenic-perforations-due-to-endoscopic-submucosal-dissection
#7
Gi Jun Kim, Sung Min Park, Joon Sung Kim, Jeong Seon Ji, Byung Wook Kim, Hwang Choi
Objectives. Endoscopic resection (ER) is commonly performed to treat gastric epithelial neoplasms and subepithelial tumors. The aim of this study was to predict the risk factors for surgery after ER-induced perforation. Methods. We retrospectively reviewed the data on patients who received gastric endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) between January 2010 and March 2015. Patients who were confirmed to have perforation were classified into surgery and nonsurgery groups...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28316621/impact-of-pressurized-intraperitoneal-aerosol-chemotherapy-on-quality-of-life-and-symptoms-in-patients-with-peritoneal-carcinomatosis-a-retrospective-cohort-study
#8
Hugo Teixeira Farinha, Fabian Grass, Amaniel Kefleyesus, Chahin Achtari, Benoit Romain, Michael Montemurro, Nicolas Demartines, Martin Hübner
Background. Peritoneal cancer treatment aims to prolong survival, but preserving Quality of Life (QoL) under treatment is also a priority. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel minimally invasive repeatable treatment modality. The aim of the present study was to assess QoL in our cohort of PIPAC patients. Methods. Analysis of all consecutive patients included from the start of PIPAC program (January 2015). QoL (0-100: optimal) and symptoms (no symptom: 0-100) were measured prospectively before and after every PIPAC procedure using EORTC QLQ-C30...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28316620/clinical-outcomes-and-safety-of-partial-full-thickness-myotomy-versus-circular-muscle-myotomy-in-peroral-endoscopic-myotomy-for-achalasia-patients
#9
Chenyu Li, Aixia Gong, Jingwen Zhang, Zhijun Duan, Linmei Ge, Nan Xia, Jing Leng, Mei Li, Yanjie Liu
Background. Here we aimed to evaluate and compare the efficacy and safety between partial full-thickness myotomy and circular muscle myotomy during POEM procedure in achalasia patients. Methods. Clinical data of achalasia of cardia (AC) patients who underwent POEM in our center during January 2014 to January 2015 was collected (34 cases). 19 patients who received partial full-thickness myotomy were assigned to group A and 14 patients who received circular muscle myotomy were assigned to group B. The procedure-related parameters between the two groups were compared...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28286517/tumor-budding-upa-and-pai-1-in-colorectal-cancer-update-of-a-prospective-study
#10
Bruno Märkl, Jochen Hardt, Simon Franz, Tina Schaller, Gerhard Schenkirsch, Bernadette Kriening, Reinhard Hoffmann, Stefan Rüth
Aims. The prognostic role of the proteases uPA and PAI-1, as well as tumor budding, in colon cancer, has been investigated previously. Methods. We provide 6-year follow-up data and results of the validation set. The initial test set and validation set consisted of 55 colon cancers and 68 colorectal cancers, respectively. Tissue samples were analyzed for uPA and PAI-1 using a commercially available Enzyme-Linked Immunosorbent Assay (ELISA). Tumor budding was analyzed on cytokeratin-stained slides. Survival analyses were performed using cut-offs that were determined previously...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28270848/platelet-count-to-spleen-diameter-ratio-for-the-diagnosis-of-gastroesophageal-varices-in-liver-cirrhosis-a-systematic-review-and-meta-analysis
#11
REVIEW
Runhua Chen, Han Deng, Xia Ding, Chune Xie, Wei Wang, Qian Shen
Platelet count to spleen diameter ratio (PSR) was studied extensively as a noninvasive method of diagnosis for varices. The present study aimed to systematically assess the performance of PSR in the diagnosis of varices. PubMed, EMBASE, and article references were searched. The summary receiver operating characteristic curves (AUSROCs), sensitivities, specificities, positive and negative likelihood ratio, and diagnostic odds ratio were calculated. The heterogeneity, quality, and publication bias of studies were evaluated...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28265285/accuracy-of-colon-capsule-endoscopy-in-detecting-colorectal-polyps-in-individuals-with-familial-colorectal-cancer-could-we-avoid-colonoscopies
#12
Cristina Alvarez-Urturi, Gloria Fernández-Esparrach, Inés Ana Ibáñez, Cristina Rodríguez De Miguel, Josep Maria Dedeu, Xavier Bessa, Henry Córdova, Maria Pellisé, Francesc Balaguer, Angels Ginés, Luis Barranco, Isis K Araujo, Montserrat Andreu, Josep Llach, Antoni Castells, Begoña González-Suarez
Background. Individuals with a family history of colorectal cancer (CRC) have an increased risk of CRC. We evaluated the diagnostic yield of CCE in the detection of lesions and also two different colon preparations. Methods. A prospective multicenter study was designed to assess CCE diagnostic yield in a cohort of asymptomatic individuals with a family history of CRC. CCE and colonoscopy were performed on the same day by 2 endoscopists who were blinded to the results of the other procedure. Results. Fifty-three participants were enrolled...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28250766/novel-implications-in-molecular-diagnosis-of-lynch-syndrome
#13
REVIEW
Raffaella Liccardo, Marina De Rosa, Paola Izzo, Francesca Duraturo
About 10% of total colorectal cancers are associated with known Mendelian inheritance, as Familial Adenomatous Polyposis (FAP) and Lynch syndrome (LS). In these cancer types the clinical manifestations of disease are due to mutations in high-risk alleles, with a penetrance at least of 70%. The LS is associated with germline mutations in the DNA mismatch repair (MMR) genes. However, the mutation detection analysis of these genes does not always provide informative results for genetic counseling of LS patients...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28246528/clinical-performance-of-prediction-rules-and-nasogastric-lavage-for-the-evaluation-of-upper-gastrointestinal-bleeding-a-retrospective-observational-study
#14
Hassan K Dakik, F Douglas Srygley, Shih-Ting Chiu, Shein-Chung Chow, Deborah A Fisher
Introduction. The majority of patients with acute upper gastrointestinal bleeding (UGIB) are admitted for urgent endoscopy as it can be difficult to determine who can be safely managed as an outpatient. Our objective was to compare four clinical prediction scoring systems: Glasgow Blatchford Score (GBS) and Clinical Rockall, Adamopoulos, and Tammaro scores in a sample of patients presenting to the emergency department of a large US academic center. Methods. We performed a retrospective cohort study of patients during 2008-2010...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28243252/neurobiological-mechanism-of-acupuncture-for-relieving-visceral-pain-of-gastrointestinal-origin
#15
REVIEW
Fang Zhang, Luyi Wu, Jimeng Zhao, Tingting Lv, Zhihai Hu, Zhijun Weng, Shuoshuo Wang, Huangan Wu, Huirong Liu
It is currently accepted that the neural transduction pathways of gastrointestinal (GI) visceral pain include the peripheral and central pathways. Existing research on the neurological mechanism of electroacupuncture (EA) in the treatment of GI visceral pain has primarily been concerned with the regulation of relevant transduction pathways. The generation of pain involves a series of processes, including energy transduction of stimulatory signals in the sensory nerve endings (signal transduction), subsequent conduction in primary afferent nerve fibers of dorsal root ganglia, and transmission to spinal dorsal horn neurons, the ascending transmission of sensory signals in the central nervous system, and the processing of sensory signals in the cerebral cortex...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28232848/the-application-of-hemospray-in-gastrointestinal-bleeding-during-emergency-endoscopy
#16
Alexander F Hagel, Heinz Albrecht, Andreas Nägel, Francesco Vitali, Marcel Vetter, Christine Dauth, Markus F Neurath, Martin Raithel
Introduction. Gastrointestinal bleeding represents the main indication for emergency endoscopy (EE). Lately, several hemostatic powders have been released to facilitate EE. Methods. We evaluated all EE in which Hemospray was used as primary or salvage therapy, with regard to short- and long-term hemostasis and complications. Results. We conducted 677 EE in 474 patients (488 examinations in 344 patients were upper GI endoscopies). Hemospray was applied during 35 examinations in 27 patients (19 males), 33 during upper and 2 during lower endoscopy...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28232847/replaceable-jejunal-feeding-tubes-in-severely-ill-children
#17
Tabea Pang, Sergio B Sesia, Stefan Holland-Cunz, Johannes Mayr
Long-term enteral nutrition in chronically ill, malnourished children represents a clinical challenge if adequate feeding via nasogastric or gastrostomy tubes fails. We evaluated the usefulness and complications of a new type of surgical jejunostomy that allows for easier positioning and replacement of the jejunal feeding tube in children. We surgically inserted replaceable jejunal feeding tubes (RJFT) connected to a guide thread which exited through a separate tiny opening of the abdominal wall. In a retrospective case series, we assessed the effectiveness and complications of this technique in severely ill children suffering from malnutrition and complex disorders...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28210270/face-to-face-cognitive-behavioral-therapy-for-irritable-bowel-syndrome-the-effects-on-gastrointestinal-and-psychiatric-symptoms
#18
Hanna Edebol-Carlman, Brjánn Ljótsson, Steven J Linton, Katja Boersma, Martien Schrooten, Dirk Repsilber, Robert J Brummer
Irritable bowel syndrome (IBS) is a gastrointestinal disorder linked to disturbances in the gut-brain axis. Visceral hypersensitivity and pain are hallmarks of IBS and linked to the physiological and psychological burden and to the nonadaptive coping with stress. Cognitive-behavioral therapy (CBT) for IBS has proven effective in reducing gastrointestinal and psychiatric symptoms in IBS by means of coping with stress. The present pilot study evaluated for the first time whether CBT for IBS affected visceral sensitivity and pain...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28210269/low-prevalence-of-clinically-significant-endoscopic-findings-in-outpatients-with-dyspepsia
#19
Khaled Abdeljawad, Antonios Wehbeh, Emad Qayed
Background. The value of endoscopy in dyspeptic patients is questionable. Aims. To examine the prevalence of significant endoscopic findings (SEFs) and the utility of alarm features and age in predicting SEFs in outpatients with dyspepsia. Methods. A retrospective analysis of outpatient adults who had endoscopy for dyspepsia. Demographic variables, alarm features, and endoscopic findings were recorded. We defined SEFs as peptic ulcer disease, erosive esophagitis, malignancy, stricture, or findings requiring specific therapy...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28210268/protective-effect-of-daikenchuto-on-dextran-sulfate-sodium-induced-colitis-in-mice
#20
Takaharu Matsunaga, Shinichi Hashimoto, Naoki Yamamoto, Ryo Kawasato, Tomohiro Shirasawa, Atsushi Goto, Koichi Fujisawa, Taro Takami, Takeshi Okamoto, Jun Nishikawa, Isao Sakaida
Aim. To investigate the effect of daikenchuto (TJ-100; DKT) for ulcerative colitis (UC) model mouse and assess its anti-inflammatory mechanisms. Methods. We evaluated the effects of DKT on dextran sulfate sodium- (DSS-) induced experimental colitis. First, we assessed the short-term effects of DKT using two groups: 5% DSS group and 5% DSS with DKT group. Colon length; histological scores; and interleukin- (IL-) 10, IL-1β, and tumor necrosis factor-α mRNA expression profiles were analyzed using real-time PCR...
2017: Gastroenterology Research and Practice
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