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Gastroenterology Research and Practice

Penglei Ge, Huayu Yang, Jingfen Lu, Wenjun Liao, Shunda Du, Yingli Xu, Haifeng Xu, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Jiefu Huang, Yilei Mao
Background. Currently there is no indicator that can evaluate actual liver lesion for early stages of viral hepatitis, nonalcoholic fatty liver disease (NAFLD), and cirrhosis. Aim of this study was to investigate if albumin binding function could better reflect liver function in these liver diseases. Methods. An observational study was performed on 193 patients with early NAFLD, viral hepatitis, and cirrhosis. Cirrhosis patients were separated according to Child-Pugh score into A, B, and C subgroup. Albumin metal ion binding capacity (Ischemia-modified albumin transformed, IMAT) and fatty acid binding capacity (total binding sites, TBS) were detected...
2016: Gastroenterology Research and Practice
Yuqing Zhou, Qian Dong, Rong Zhang, Shunfeng Zhou, Linqiang Li, Keran Cheng, Rui Kong, Qiang Yu, Shizan Xu, Jingjing Li, Sainan Li, Jiao Feng, Liwei Wu, Tong Liu, Xiya Lu, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Chuanyong Guo
: Aims. To investigate cerebral hemodynamics in cirrhotic patients with HE and to observe effects of treatment in cerebral hemodynamics and correlations among ammonia, cerebral hemodynamics, and cognitive function. Methods. There were four groups: healthy controls (group 1), cirrhosis without HE (group 2), cirrhosis with MHE (group 3), and cirrhosis with OHE (group 4). Ammonia and cerebral hemodynamics (by TCD) were assessed. Patients in group 3 were subsequently randomized to two subgroups: the control (group A) and the treated (group B, treated with lactulose for two months), and they were retested for ammonia and TCD after treatment...
2016: Gastroenterology Research and Practice
Yoichiro Okubo, Tomoyuki Yokose, Osamu Motohashi, Yohei Miyagi, Emi Yoshioka, Masaki Suzuki, Kota Washimi, Kae Kawachi, Madoka Nito, Tetsuo Nemoto, Kazutoshi Shibuya, Yoichi Kameda
Gangliocytic paraganglioma (GP) has been regarded as a rare benign tumor that commonly arises from the second part of the duodenum. As GP does not exhibit either prominent mitotic activity or Ki-67 immunoreactivity, it is often misdiagnosed as neuroendocrine tumor (NET) G1. However, the prognosis might be better in patients with GP than in those with NET G1. Therefore, it is important to differentiate GP from NET G1. Moreover, our previous study indicated that GP accounts for a substantial, constant percentage of duodenal NETs...
2016: Gastroenterology Research and Practice
Qitian He, Quan He, Xue Qin, Shan Li, Taijie Li, Li Xie, Yan Deng, Yu He, Yongbin Chen, Zhifu Wei
Background. Red cell distribution width (RDW) and platelet-lymphocyte ratio (PLR) have been studied in a variety of etiological diseases. We aim to investigate the relationship between RDW and PLR and the severity of hepatitis C virus- (HCV-) related liver disease. Methods. We included fifty-two chronic HCV and 42 HCV-related cirrhosis patients and 84 healthy controls. Hematological and virological parameters and liver function biomarkers of HCV-related patients at admission were recorded. Results. RDW, RDW-to-platelet (RPR), and 1/PLR values in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients and healthy controls (all P < 0...
2016: Gastroenterology Research and Practice
Hironori Konuma, Kenshi Matsumoto, Hiroya Ueyama, Hiroyuki Komori, Yoichi Akazawa, Misuzu Ueyama, Yuta Nakagawa, Takashi Morimoto, Tsutomu Takeda, Kohei Matsumoto, Daisuke Asaoka, Mariko Hojo, Akihito Nagahara, Takashi Yao, Akihisa Miyazaki, Sumio Watanabe
Background. Previous assessments of technical difficulty and procedure time for endoscopic submucosal dissection (ESD) of gastric neoplasms did not take into account several critical determinants of these parameters. However, two key phases of ESD determine the total procedure time: the mucosal circumference incision speed (CIS) and submucosal dissection speed (SDS). Methods. We included 302 cases of en bloc and R0 resection of gastric neoplasms performed by 10 operators who had completed the training program at our hospital...
2016: Gastroenterology Research and Practice
Dawei Gong, Xiaojie Gong, Lili Wang, Xinjuan Yu, Quanjiang Dong
A considerable number of studies have been conducted to study the microbial profiles in inflammatory conditions. A common phenomenon in inflammatory bowel disease (IBD) is the reduction of the diversity of microbiota, which demonstrates that microbial diversity negatively correlates with disease severity in IBD. Increased microbial diversity is known to occur in disease remission. Species diversity plays an important role in maintaining the stability of the intestinal ecosystem as well as normal ecological function...
2016: Gastroenterology Research and Practice
Xiao-Dong Sun, Chen Huan, Wei Qiu, Da-Wei Sun, Xiao-Ju Shi, Chuan-Lei Wang, Chao Jiang, Guang-Yi Wang, Guo-Yue Lv
Purpose. Urothelial carcinoma-associated 1 (UCA1) has been reported to be overexpressed and correlated with progression in various cancers. However, the association between UCA1 expression and some clinicopathological features of digestive system malignancies, such as metastasis and survival, remains inconclusive. Therefore, a meta-analysis was performed to investigate the clinical significance of UCA1 in digestive system malignancies. Methods. Relevant literatures were searched in PubMed, Web of Science, Cochrane Library, and Embase databases updated to May 2016...
2016: Gastroenterology Research and Practice
Mohamad H Imam, Sooraj Tejaswi, Mohammed Nabil Quraishi, James H Tabibian
No abstract text is available yet for this article.
2016: Gastroenterology Research and Practice
Yanyan Shi, Ying Wei, Ting Zhang, Jing Zhang, Ye Wang, Shigang Ding
Background. Pathologic duodenogastric reflux can induce or aggravate gastritis because of the presence of bile acids. Bile reflux has been generally considered to be associated with intestinal metaplasia and gastric cancer. However, the pathogenic mechanisms of the effects of bile acids on gastric mucosa are still unknown. Methods. To explore the mechanisms by which bile acids induce gastric mucosal lesions, we examined cell apoptosis in the gastric epithelial cell line GES-1 and investigated the changes in protein profiles of GES-1 cells in response to a bile acid deoxycholic acid using a proteomics approach...
2016: Gastroenterology Research and Practice
Ju Yup Lee, Kyung Sik Park
A new treatment strategy is needed, as the efficacy of triple therapy containing clarithromycin-the current standard treatment for Helicobacter pylori infection-is declining. Increasing antibiotic resistance of H. pylori is the most significant factor contributing to eradication failure. Thus, selecting the most appropriate regimen depending on resistance is optimal, but identifying resistance to specific antibiotics is clinically challenging. In a region suspected to have high clarithromycin resistance, bismuth quadruple therapy and so-called nonbismuth quadruple therapies (sequential, concomitant, and sequential-concomitant hybrid) are some first-line regimen options...
2016: Gastroenterology Research and Practice
Goh Eun Chung, Jeong Yoon Yim, Donghee Kim, Min-Sun Kwak, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim
Aims. Chronic low-grade inflammation is thought to be associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study aimed to determine the association between serum white blood cell (WBC) counts and the development of incidental NAFLD. Methods. In this retrospective longitudinal cohort study, we recruited participants who underwent abdominal ultrasonography and blood samplings during medical checkups in both 2005 and 2010. A total of 2,216 subjects were included in our analyses. Results...
2016: Gastroenterology Research and Practice
Carmelo Luigiano, Giuseppe Iabichino, Leonardo Henry Eusebi, Monica Arena, Pierluigi Consolo, Carmela Morace, Enrico Opocher, Benedetto Mangiavillano
Barrett's esophagus is a condition in which the normal squamous lining of the esophagus has been replaced by columnar epithelium containing intestinal metaplasia induced by recurrent mucosal injury related to gastroesophageal reflux disease. Barrett's esophagus is a premalignant condition that can progress through a dysplasia-carcinoma sequence to esophageal adenocarcinoma. Multiple endoscopic ablative techniques have been developed with the goal of eradicating Barrett's esophagus and preventing neoplastic progression to esophageal adenocarcinoma...
2016: Gastroenterology Research and Practice
Francesca A R Silva, Bruno L Rodrigues, Maria de Lourdes S Ayrizono, Raquel F Leal
Inflammatory bowel diseases (IBDs) are chronic ailments, Crohn's disease and ulcerative colitis being the most important. These diseases present an inflammatory profile and they differ according to pathophysiology, the affected area in the gastrointestinal tract, and the depth of the inflammation in the intestinal wall. The immune characteristics of IBD arise from abnormal responses of the innate and adaptive immune system. The number of Th17 cells increases in the peripheral blood of IBD patients, while Treg cells decrease, suggesting that the Th17/Treg proportion plays an important role in the development and maintenance of inflammation...
2016: Gastroenterology Research and Practice
Carthage Moran, Donal Sheehan, Fergus Shanahan
It is widely known that there have been improvements in patient care and an increased incidence of Inflammatory Bowel Disease (IBD) worldwide in recent decades. However, less well known are the phenotypic changes that have occurred; these are discussed in this review. Namely, we discuss the emergence of obesity in patients with IBD, elderly onset disease, mortality rates, colorectal cancer risk, the burden of medications and comorbidities, and the improvement in surgical treatment with a decrease in surgical rates in recent decades...
2016: Gastroenterology Research and Practice
Mikito Inokuchi, Sho Otsuki, Norihito Ogawa, Toshiro Tanioka, Keisuke Okuno, Kentaro Gokita, Tatsuyuki Kawano, Kazuyuki Kojima
Background. Some meta-analyses of case-controlled studies (CCSs) have shown that laparoscopic or laparoscopy-assisted total gastrectomy (LTG) had some short-term advantages over open total gastrectomy (OTG). However, postoperative complications differed somewhat among the meta-analyses, and some CCSs included in the meta-analyses had mismatched factors between LTG and OTG. Methods. CCSs comparing postoperative complications between LTG and OTG were identified in PubMed and Embase. Studies matched for patients' status, tumor stage, and the extents of lymph-node dissection were included...
2016: Gastroenterology Research and Practice
Yuting Qian, Sheng Wu, Qi Wang, Lumin Wei, Wei Wu, Lifu Wang, Ye Chu
Objectives. Achieving a comprehensive view of gastric mucosa has been a challenge for magnetic-guided capsule endoscopy (MGCE) for years. This study works on optimizing the performance of MGCE by changing the conventional positions to the five body positions. Methods. Sixty patients were enrolled in the study and underwent MGCE. All patients were asked to adopt five body positions (left lateral, supine, right lateral, knee-chest, and sitting). In each position, the ability to visualize the six gastric landmarks (cardia, fundus, body, angulus, antrum, and pylorus) was assessed...
2016: Gastroenterology Research and Practice
Randi Opheim, Marte Lie Høivik, Tomm Bernklev, Lars-Petter Jelsness-Jørgensen, Bjørn Moum
Background and Aims. Complementary and alternative medicine (CAM) use among patients with inflammatory bowel disease (IBD) is common. The aim of this study was to explore associations between CAM use and health-related quality of life (HRQoL) as well as identifying whether sociodemographic factors, disease activity, and personal resources (self-efficacy) influence HRQoL scores in users and nonusers of CAM. Methods. Measures included sociodemographic and disease-related data, the International-CAM Questionnaire, and General Self-Efficacy Scale...
2016: Gastroenterology Research and Practice
Tao Guo, Yukun He, Weijie Ma, Zhisu Liu, Quanyan Liu
Aims. To understand the feasibility and efficacy of treatment with SAMe in patients with hepatitis B-related HCC with different Barcelona Clinic Liver Cancer (BCLC) stages. Methods. We retrospectively enrolled 697 patients with BCLC early-stage (stages 0-A) and advanced-stage (stages B-C) HCC who underwent SAMe therapy (354 cases) or no SAMe therapy (343 cases). The baseline characteristics, postoperative recoveries, and 24-month overall survival rates of the patients in the 2 groups were compared. Cox regression model analysis was performed to confirm the independent variables influencing the survival rate...
2016: Gastroenterology Research and Practice
Giuseppe Lo Re, Federica Vernuccio, Federico Midiri, Dario Picone, Giuseppe La Tona, Massimo Galia, Antonio Lo Casto, Roberto Lagalla, Massimo Midiri
[This corrects the article DOI: 10.1155/2016/2498143.].
2016: Gastroenterology Research and Practice
Bülent Ödemiş, Ufuk Barış Kuzu, Erkin Öztaş, Fatih Saygılı, Nuretdin Suna, Orhan Coskun, Adem Aksoy, Zeliha Sırtaş, Derya Arı, Yener Akpınar
Background. Most common bile duct (CBD) stones can be removed with standard techniques using endoscopic retrograde cholangiopancreatography (ERCP), but in some cases additional methods are needed. In this study we aimed to investigate the management of patients with difficult stones and the factors that affect the outcome of patients that have undergone periodic endobiliary stenting. Materials and Methods. Data of 1529 patients with naive papilla who had undergone ERCP with an indication of CBD stones was evaluated retrospectively...
2016: Gastroenterology Research and Practice
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