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Gastroenterology Research and Practice

Hamid Reza Ghasemi Basir, Mehdi Ghobakhlou, Parvin Akbari, Arash Dehghan, Mohamad Ali Seif Rabiei
Background: The most common cause of chronic gastritis is infection with Helicobacter pylori. Identifying the relationship between intensities of colonization and activity of gastritis helps the clinician in more effective treatment and posttreatment follow-ups. Methods: In this cross-sectional study, endoscopic gastric biopsy samples of 544 patients who complained symptoms of dyspepsia for more than three months referring to the laboratory were studied. To determine the colonization rate of H...
2017: Gastroenterology Research and Practice
Ali Ridha, Yasir Al-Abboodi, Matthew Fasullo
There are only a few studies with a small sample size of patients that have compared the risks of using chest tubes versus thoracentesis in hepatic hydrothorax. It has been shown that many complications may arise secondary to chest tube placement and is associated with increased morbidity and mortality. In this retrospective study, patients with cirrhosis were identified from the 2009 National Inpatient Sample by using ICD-9 codes; we evaluated the risk of chest tube versus thoracentesis in a largest population with hepatic hydrothorax to date to measure the mortality and the length of stay...
2017: Gastroenterology Research and Practice
Yongrui Bai, Yuejuan Xu, Bin Wu
Objective: This study evaluated the cost-effectiveness of apatinib in patients with chemotherapy-refractory mGC. Patients and Methods: A Markov model was developed to simulate the clinical course of typical patients with chemotherapy-refractory metastatic gastric cancer (mGC). We estimated the 10-year quality-adjusted life-years (QALY), costs, and incremental cost-effectiveness ratios (ICER). Model inputs were derived from the published literature and government sources...
2017: Gastroenterology Research and Practice
E E van Eeghen, M J Flens, M M R Mulder, R J L F Loffeld
Aim: Extramural venous invasion (EMVI) is a prognostic indicator in patients with colorectal cancer. However, its additional value in patients with stage 1 and 2 colorectal cancer is uncertain. In the present study, the incidence of EMVI and the hazard ratio for recurrence in patients with stage 1 and 2 colon cancer were studied. Methods: 184 patients treated for stage 1 and 2 colon cancer were included with a follow-up of at least 5 years. Chart review was performed and EMVI was assessed by two separate pathologists...
2017: Gastroenterology Research and Practice
Binbin Mei, Wenting Wang, Feifei Cui, Zunjia Wen, Meifen Shen
Background: This meta-analysis was performed to assess the efficacy and safety of chewing gum in intestinal function recovery after colorectal cancer surgery. Methods: A systematic search was conducted in PubMed, Embase, Science Direct, and Cochrane library for relevant randomized controlled trials (RCTs) published until April 2017. Summary risk ratios or weighted mean differences with 95% confidence intervals were used for continuous and dichotomous outcomes, respectively...
2017: Gastroenterology Research and Practice
Kazuhiro Mizukami, Ryo Ogawa, Kazuhisa Okamoto, Mitsutaka Shuto, Kensuke Fukuda, Akira Sonoda, Osamu Matsunari, Yuka Hirashita, Tadayoshi Okimoto, Masaaki Kodama, Kazunari Murakami
Objectives: We aimed to determine whether linked color imaging (LCI), a new image-enhanced endoscopy that enhances subtle differences in mucosal colors, can distinguish the border of endoscopic mucosal atrophy. Methods: This study included 30 patients with atrophic gastritis. In endoscopy, we continuously took images in the same composition with both LCI and white light imaging (WLI). In each image, the color values of atrophic and nonatrophic mucosae were quantified using the International Commission on Illumination 1976 (L∗, a∗, b∗) color space...
2017: Gastroenterology Research and Practice
Andrea Balla, Silvia Quaresima, Pietro Ursi, Ardit Seitaj, Livia Palmieri, Danilo Badiali, Alessandro M Paganini
Introduction: In obese patients with hiatal hernia (HH), laparoscopic sleeve gastrectomy (LSG) with cruroplasty is an option but use of prosthetic mesh crura reinforcement is debated. The aim was to compare the results of hiatal closure with or without mesh buttressing during LSG. Methods: Gastroesophageal reflux disease (GERD) was assessed by the Health-Related Quality of Life (GERD-HRQL) questionnaire before and after surgery in two consecutive series of patients with esophageal hiatus ≤ 4 cm2...
2017: Gastroenterology Research and Practice
C Römmele, A Ebigbo, M Schrempf, H Messmann, S K Gölder
Background and Aims: Balloon-assisted enteroscopy (BAE) is a well-established tool in the diagnosis and therapy of small bowel diseases. Ink tattooing of the small bowel is used to mark pathologic lesions or the depth of small bowel insertion. The purpose of this study was to determine the safety, the detection rate, and the clinical relevance of ink tattooing during BAE. Methods: We performed a retrospective analysis of all 81 patients who received an ink tattooing during BAE between 2010 and 2015...
2017: Gastroenterology Research and Practice
Kosuke Nomura, Toshiro Iizuka, Daisuke Kaji, Hisashi Yamamoto, Yasutaka Kuribayashi, Masami Tanaka, Tsukasa Furuhata, Satoshi Yamashita, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Yasunori Ota, Shuichi Taniguchi, Shu Hoteya
Background and Aims: We retrospectively investigated the incidence of acute graft-versus-host disease (GVHD) in the lower gastrointestinal (GI) tract and the diagnostic accuracy of endoscopy. Methods: Of 1231 patients who underwent allogeneic hematopoietic stem cell transplantation between January 2005 and December 2014, 186 of whom underwent colonoscopy and biopsy and had no cytomegalovirus infection. The endoscopic findings and histologic diagnosis from these 186 patients were retrospectively analyzed...
2017: Gastroenterology Research and Practice
Lin Li, Ketong Wu, Haiyang Lai, Bo Zhang
Objective: The aim of our research is to explore the clinical efficacy and safety of CT-guided percutaneous microwave ablation (MWA) for the treatment of lung metastasis from colorectal cancer. Materials and Methods: CT-guided percutaneous MWA was performed in 22 patients (male 14, female 8, mean age: 56.05 ± 12.32 years) with a total of 36 lung metastatic lesions from colorectal cancer between February 2014 and May 2017. Clinical data were retrospectively analyzed with respect to the efficacy, safety, and outcome...
2017: Gastroenterology Research and Practice
Caroline Gronnier, Fabian Grass, Christiane Petignat, Basile Pache, Dieter Hahnloser, Giorgio Zanetti, Nicolas Demartines, Martin Hübner
Background: The present study aimed to evaluate a potential effect of ERAS on surgical site infections (SSI). Methods: Colonic surgical patients operated between May 2011 and September 2015 constituted the cohort for this retrospective analysis. Over 100 items related to demographics, surgical details, compliance, and outcome were retrieved from a prospectively maintained database. SSI were traced by an independent National surveillance program. Risk factors for SSI were identified by univariate and multinomial logistic regression...
2017: Gastroenterology Research and Practice
Vendel Kristensen, Arne Røseth, Tahir Ahmad, Viggo Skar, Bjørn Moum
Objectives: Mucosal healing has become the new goal of treatment in ulcerative colitis. Fecal calprotectin has been demonstrated to differentiate between mucosal inflammation and mucosal healing. With this project, we investigated whether a reduction in f-calprotectin to <250 μg/g after medical treatment for active ulcerative colitis could predict mucosal healing. Material and Methods: After a baseline colonoscopy, 20 patients with active ulcerative colitis were followed with consecutive fecal calprotectin monthly until two measurements of fecal calprotectin < 250 μg/g or a maximum follow-up of 12 months...
2017: Gastroenterology Research and Practice
G Lamberti, C Ceccarelli, N Brighi, I Maggio, D Santini, C Mosconi, C Ricci, G Biasco, D Campana
Purpose: To evaluate the role of the activation of mTOR (phosphorylated mTOR, p-mTOR) and the expression SSTR2A and IGF-1R as prognostic factor in well-differentiated neuroendocrine tumors. Methods: A retrospective study was conducted on data from patients with diagnosis of neuroendocrine tumor originated from pancreas (pNET) or gastrointestinal tract (stomach, appendix, and ileus; GI-NET) made between January 2003 and December 2004 and followed up at our institution...
2017: Gastroenterology Research and Practice
Svein Oskar Frigstad, Anne Haaber, Antal Bajor, Jan Fallingborg, Per Hammarlund, Ole K Bonderup, Håkan Blom, Terje Rannem, Per M Hellström
Background: Intravenous iron allows for efficient and well-tolerated treatment in iron deficiency and is routinely used in diseases of the gastrointestinal tract. Objective: The aims of this study were to determine the probability of relapse of iron deficiency over time and to investigate treatment routine, effectiveness, and safety of iron isomaltoside. Methods: A total of 282 patients treated with iron isomaltoside were observed for two treatments or a minimum of one year...
2017: Gastroenterology Research and Practice
Cristina Stasi, Cristiana Nisita, Sonia Cortopassi, Giorgio Corretti, Dario Gambaccini, Nicola De Bortoli, Bernardo Fani, Natalia Simonetti, Angelo Ricchiuti, Liliana Dell'Osso, Santino Marchi, Massimo Bellini
Background and Aims: Functional gastrointestinal disorders (FGDs) are multifactorial disorders of the gut-brain interaction. This study investigated the prevalence of Axis I and spectrum disorders in patients with FGD and established the link between FGDs and psychopathological dimensions. Methods: A total of 135 consecutive patients with FGD were enrolled. The symptoms' severity was evaluated using questionnaires, while the psychiatric evaluation by clinical interviews established the presence/absence of mental (Diagnostic and Statistical Manual-4th edition, Axis I Diagnosis) or spectrum disorders...
2017: Gastroenterology Research and Practice
Petros Ypsilantis, Maria Lambropoulou, Antonios Evagellou, Nikolaos Papadopoulos, Constantinos Simopoulos
Background and Aim: Extended liver radiofrequency ablation (RFA) has been shown to disrupt gut barrier integrity with subsequent bacterial translocation. The aim of the present project was to study the immune and inflammatory responses of the intestinal mucosa after extended RFA of the liver. Methods: Twelve Wistar rats were either subjected to RFA of the left lateral hepatic lobe (approximately 30% of the liver mass) after midline laparotomy (group RFA, n = 6) or sham operation (group Sham, n = 6)...
2017: Gastroenterology Research and Practice
Yin-Mei Fu, Ming Chen, Ai-Jun Liao
Purpose: This study aimed to evaluate the therapeutic value of adalimumab (ADA) for fistula in Crohn's disease (CD). Methods: A computerized search of electronic databases, including PubMed, Web of Science, Embase, Google scholar, and the Cochrane Library from 2000 to October 2016, was performed. Randomized controlled trials (rcts) or nonrandomized controlled trials (n-rcts) were included in this article to evaluate the role of ADA in the management of fistula in CD...
2017: Gastroenterology Research and Practice
Marco Milone, Ugo Elmore, Andrea Vignali, Alfredo Mellano, Nicola Gennarelli, Michele Manigrasso, Francesco Milone, Giovanni Domenico De Palma, Andrea Muratore, Riccardo Rosati
Aim: To evaluate the impact of open or laparoscopic rectal surgery on pulmonary complications in elderly (>75 years old) patients. Methods: Data from consecutive patients who underwent elective laparoscopic or open rectal surgery for cancer were collected prospectively from 3 institutions. Pulmonary complications were defined according to the ACS/NSQUIP definition. Results: A total of 477 patients (laparoscopic group: 242, open group: 235) were included in the analysis...
2017: Gastroenterology Research and Practice
Anas Kh Al-Saffar, Carl Hampus Meijer, Venkata Ram Gannavarapu, Gustav Hall, Yichen Li, Hetzel O Diaz Tartera, Mikael Lördal, Tryggve Ljung, Per M Hellström, Dominic-Luc Webb
Intestinal fatty acid binding protein (I-FABP) indicates barrier integrity. AIMS: determine if I-FABP is elevated in active Crohn's disease (CD) and if I-FABP parallels anti-TNFα antibody (infliximab) induced lowering of TNFα and Harvey-Bradshaw Index (HBI) as potential indicator of mucosal healing. I-FABP distribution along human gut was determined. Serum from 10 CD patients collected during first three consecutive infliximab treatments with matched pretreatment and follow-up samples one week after each treatment and corresponding HBI data were analyzed...
2017: Gastroenterology Research and Practice
Per G Farup, Thor Ueland, Knut Rudi, Stian Lydersen, Knut Hestad
Background: Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication. This study explored associations between functional gastrointestinal disorders (FGID) and inflammatory markers in subjects with these disorders. Methods: The FGID, including irritable bowel syndrome (IBS), were classified according to the Rome III criteria, and degree of symptoms was assessed with IBS symptom severity score (IBS-SSS)...
2017: Gastroenterology Research and Practice
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