journal
https://read.qxmd.com/read/38516783/combining-a-glycolysis%C3%A2-related-prognostic-model-based-on-scrna%C3%A2-seq-with-experimental-verification-identifies-zfp41-as-a-potential-prognostic-biomarker-for-hcc
#21
JOURNAL ARTICLE
Yu Teng, Jianrong Xu, Yaoqun Wang, Ningyuan Wen, Hui Ye, Bei Li
Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis, and its heterogeneity affects the response to clinical treatments. Glycolysis is highly associated with HCC therapy and prognosis. The present study aimed to identify a novel biomarker for HCC by exploring the heterogeneity of glycolysis in HCC. The intersection of both marker genes of glycolysis‑related cell clusters from single‑cell RNA sequencing analysis and mRNA data of liver HCC from The Cancer Genome Atlas were used to construct a prognostic model through Cox proportional hazard regression and the least absolute shrinkage and selection operator Cox regression...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38516774/mirna%C3%A2-21-promotes-the-progression-of-acute-liver-failure-via-the-klf6-autophagy-il%C3%A2-23-signaling-pathway
#22
JOURNAL ARTICLE
Suxia Bao, Weiyang Zheng, Rong Yan, Jie Xu
Acute liver failure (ALF) is a complex syndrome characterized by overactivation of innate immunity, and the recruitment and differentiation of immune cells at inflammatory sites. The present study aimed to explore the role of microRNA (miRNA/miR)‑21 and its potential mechanisms underlying inflammatory responses in ALF. Baseline serum miR‑21 was analyzed in patients with ALF and healthy controls. In addition, miR‑21 antagomir was injected via the tail vein into C57BL/6 mice, and lipopolysaccharide/D‑galactosamine (LPS/GalN) was injected into mice after 48 h...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38516773/-retracted-oncogenic-mir-23a-5p-is-associated-with-cellular-function-in-rcc
#23
Jing Quan, Lu Jin, Xiang Pan, Tao He, Yulin Lai, Peijie Chen, Canbin Lin, Shangqi Yang, Hui Zeng, Yongqing Lai
Following the publication of this article, a concerned reader drew to the Editor's attention that, for the invasion and migration assay data shown in Fig. 4 on p. 2314, three pairs of data panels were overlapping, such that data which were intended to show the results from differently performed experiments were obtained from a smaller number of original sources. Moreover, after having conducted an internal investigation, the Editorial Office also observed that some of the flow cytometric data shown in Fig. 6 were duplicated in Fig...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38516772/puerarin-attenuates-remifentanil%C3%A2-induced-postoperative-hyperalgesia-via-targeting-pax6-to-regulate-the-transcription-of-trpv1
#24
JOURNAL ARTICLE
Libang Yuan, Yinghai Liu, Yangyang Sun, Ling Ren, Xiaoping Gu, Liang Chen, Gongrui Zhou, Xiaoqin Sun, Qingqing Huang, Xufei Chen, Gu Gong
Remifentanil‑induced hyperalgesia (RIH) is characterized by the emergence of stimulation‑induced pain, including phenomena such as allodynia and thermal hyperalgesia following remifentanil infusion. As a sequence‑specific DNA binding transcription factor, PAX6 positively and negatively regulates transcription and is expressed in multiple cell types in the developing and adult central nervous system. It was hypothesized that puerarin could relieve RIH via targeting PAX6 to regulate transcription of transient receptor potential cation channel subfamily V Member 1 (TRPV1)...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38516770/apoptosis-in-glaucoma-a-new-direction-for-the-treatment-of-glaucoma-review
#25
REVIEW
Qiongrong Xia, Dingding Zhang
Glaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological changes in glaucoma...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38516767/targeted-degradation-of-hexokinase-2-for-anti%C3%A2-inflammatory-treatment-in-acute-lung-injury
#26
JOURNAL ARTICLE
Jiayan Yang, Liangliang Dong, Yifan Wang, Lifen Gong, Hongwei Gao, Yicheng Xie
Acute lung injury (ALI) is an acute inflammatory lung disease associated with both innate and adaptive immune responses. Hexokinase 2 (HK2) is specifically highly expressed in numerous types of inflammation‑related diseases and models. In the present study in vitro and in vivo effects of targeted degradation of HK2 on ALI were explored. The degradation of HK2 by the targeting peptide TAT (transactivator of transcription protein of HIV‑1)‑ataxin 1 (ATXN1)‑chaperone‑mediated autophagy‑targeting motif (CTM) was demonstrated by ELISA and western blotting in vitro and in vivo ...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38516760/food-therapy-of-scutellarein-ameliorates-pirarubicin%C3%A2-induced-cardiotoxicity-in-rats-by-inhibiting-apoptosis-and-ferroptosis-through-regulation-of-nox2%C3%A2-induced-oxidative-stress
#27
JOURNAL ARTICLE
Ying Lan, Fengshun Tian, Heng Tang, Peng Pu, Quan He, Liang Duan
Pirarubicin (THP) is one of the most commonly used antineoplastic drugs in clinical practice. However, its clinical application is limited due to its toxic and heart‑related side effects. It has been reported that oxidative stress, inflammation and apoptosis are closely associated with cardiotoxicity caused by pirarubicin (CTP). Additionally, it has also been reported that scutellarein (Sc) exerts anti‑inflammatory, antioxidant, cardio‑cerebral vascular protective and anti‑apoptotic properties...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38488036/doxorubicin%C3%A2-induced-cardiomyopathy-is-mitigated-by-empagliflozin-via-the-modulation-of-endoplasmic-reticulum-stress-pathways
#28
JOURNAL ARTICLE
Akshi Malik, Ashim K Bagchi, Davinder S Jassal, Pawan K Singal
Doxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation of cardiomyocyte apoptosis...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38488034/ifn%C3%A2-%C3%AE-induces-apoptosis-in-gemcitabine%C3%A2-resistant-pancreatic-cancer-cells
#29
JOURNAL ARTICLE
Xiangxin Kong, Denglong Cheng, Xu Xu, Yuan Zhang, Xin Li, Wanlong Pan
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent and aggressive form of pancreatic cancer. Gemcitabine (GEM), the first‑line treatment for PDAC, which alleviates symptoms and enhances the quality of life of patients. However, it is prone to lead to the development of drug resistance during treatment. Interferon (IFN)‑γ exhibits antitumor and immunomodulatory properties. The present study aimed to explore the impact of IFN‑γ on the viability, migration and apoptosis of GEM‑resistant pancreatic cancer cells...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38488032/-retracted-mir%C3%A2-34a-is-downregulated-in-human-osteosarcoma-stem%C3%A2-like-cells-and-promotes-invasion-tumorigenic-ability-and-self%C3%A2-renewal-capacity
#30
Yonggen Zou, Yuanshuai Huang, Jiexiang Yang, Jian Wu, Cheng Luo
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion assay data shown in Fig. 4B on p. 1635 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were submitted at around the same time. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Molecular Medicine Reports , the Editor has decided that this paper should be retracted from the Journal...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38488031/resveratrol-ameliorates-ulcerative-colitis-by-upregulating-nrf2-ho%C3%A2-1-pathway-activity-integrating-animal-experiments-and-network-pharmacology
#31
JOURNAL ARTICLE
Xinya Yu, Xiaoxi Li, Yunchun Xu, Yuwei Li, Ye Zhou, Junhua Zhang, Le Guo
Ulcerative colitis (UC) is a chronic idiopathic inflammatory condition affecting the rectum and colon. Inflammation and compromisation of the intestinal mucosal barrier are key in UC pathogenesis. Resveratrol (Res) is a naturally occurring polyphenol that exhibits anti‑inflammatory and antioxidant properties. Nuclear factor erythroid‑2‑related factor 2/heme oxygenase 1 (Nrf2/HO‑1) pathway regulates occurrence and development of numerous types of diseases through anti‑inflammatory and antioxidant activity...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38488029/role-and-molecular-mechanisms-of-sglt2-inhibitors-in-pathological-cardiac-remodeling-review
#32
REVIEW
Bixian Chen, Jing Guo, Hongmei Ye, Xinyu Wang, Yufei Feng
Cardiovascular diseases are caused by pathological cardiac remodeling, which involves fibrosis, inflammation and cell dysfunction. This includes autophagy, apoptosis, oxidative stress, mitochondrial dysfunction, changes in energy metabolism, angiogenesis and dysregulation of signaling pathways. These changes in heart structure and/or function ultimately result in heart failure. In an effort to prevent this, multiple cardiovascular outcome trials have demonstrated the cardiac benefits of sodium‑glucose cotransporter type 2 inhibitors (SGLT2is), hypoglycemic drugs initially designed to treat type 2 diabetes mellitus...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38488028/pigment-epithelium%C3%A2-derived-factor-inhibits-proliferation-invasion-and-angiogenesis-and-induces-ferroptosis-of-extravillous-trophoblasts-by-targeting-wnt%C3%A2-%C3%AE-%C3%A2-catenin-vegf-signaling%C3%A2-in-placenta-accreta-spectrum
#33
JOURNAL ARTICLE
Rui Li, Xiaoying Weng, Xuyang Hu, Junjun Wang, Lin Zheng
Placenta accreta spectrum (PAS) is one of the most dangerous complications in obstetrics, which can lead to severe postpartum bleeding and shock, and even necessitate uterine removal. The abnormal migration and invasion of extravillous trophoblast cells (EVTs) and enhanced neovascularization occurring in an uncontrolled manner in time and space are closely related to the abnormal expression of pro‑angiogenic and anti‑angiogenic factors. The pigment epithelium‑derived factor (PEDF) is a multifunctional regulatory factor that participates in several important biological processes and is recognized as the most efficient inhibitor of angiogenesis...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38456539/rich1-is-a-novel-key-suppressor-of-isoproterenol%C3%A2-or-angiotensin-ii%C3%A2-induced-cardiomyocyte-hypertrophy
#34
JOURNAL ARTICLE
Siqi Wang, Xin Wang, Li Ling, Cairong Li, Zhanhong Ren
Cardiac hypertrophy is one of the key processes in the development of heart failure. Notably, small GTPases and GTPase‑activating proteins (GAPs) serve essential roles in cardiac hypertrophy. RhoGAP interacting with CIP4 homologs protein 1 (RICH1) is a RhoGAP that can regulate Cdc42/Rac1 and F‑actin dynamics. RICH1 is involved in cell proliferation and adhesion; however, to the best of our knowledge, its role in cardiac hypertrophy remains unknown. In the present study, the role of RICH1 in cardiomyocyte hypertrophy was assessed...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38456535/-retracted-liraglutide-repairs-the-infarcted-heart-the-role-of-the-sirt1-parkin-mitophagy-pathway
#35
Huiying Qiao, Haiyan Ren, He Du, Minfang Zhang, Xiaofang Xiong, Rong Lv
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the immunofluorescence data shown in Fig. 2G, the mitochondria‑ and lysosome‑stained images in Fig. 3C, the JC‑1 staining images in Fig. 4C and the immunofluorescence data in Fig. 5G were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Molecular Medicine Reports , or were under consideration for publication at around the same time...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38456482/-corrigendum-identification-of-lncrna-egot-as-a-tumor-suppressor-in-renal-cell-carcinoma
#36
Lu Jin, Jing Quan, Xiang Pan, Tao He, Jia Hu, Yifan Li, Yaoting Gui, Shangqi Yang, Xiangming Mao, Yun Chen, Yongqing Lai
Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, concerrning the Transwell cell migration and invasion assay data shown in Fig. 6A and B for the 786‑O cell line on p. 7206, the pcDNA3.1‑EGOT 'Migration' and 'Invasion' (a‑1 and b‑1) data panels appeared to contain overlapping sections of data, such that they were potentially derived from the same original source, where these panels were intended to show the results from differently performed experiments...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38456480/norcantharidin-inhibits-the-malignant-progression-of-cervical-cancer-by-inducing-endoplasmic-reticulum-stress
#37
JOURNAL ARTICLE
Zhongbao Zhang, Beibei Sun, Jinqiu Lu, Penglai Bai, Yu Su, Yanchun Li
The antitumor effect of norcantharidin (NCTD) has been widely reported. However, whether NCTD can inhibit cervical cancer remains unknown. In the present study, it was shown that NCTD inhibited the viability of cervical cancer cells and caused cell cycle arrest in a concentration‑dependent manner. Further analysis revealed that the NCTD‑induced reduction in cell viability could be reversed by the inhibitor of apoptosis z‑VAD‑FMK and by the inhibitor of endoplasmic reticulum (ER) stress, 4‑phenylbutyric acid (4‑PBA)...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38456519/bif%C3%A2-1-inhibits-activation-of-inflammasome-through-autophagy-regulatory-mechanism
#38
JOURNAL ARTICLE
Yuehui Zhang, Wenhui Su, Yaoyun Niu, Hongli Zeng, Lu Liu, Lijun Wang, Weidong Xie
Inflammasome activation is a crucial mechanism in inflammatory responses. Bax‑interacting factor 1 (Bif‑1) is required for the normal formation of autophagosomes, but its ability to exert an inflammatory regulatory effect remains unclear. The aim of the present study was to explore the role of Bif‑1 in inflammation, possibly mediated through autophagy regulation. Using a lipopolysaccharide (LPS)/adenosine triphosphate (ATP)‑induced inflammatory model in J774A.1 cells, the effect of Bif‑1 on inflammasome activation and the underlying mechanisms involving autophagy regulation were investigated...
April 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38426568/-corrigendum-long-non%C3%A2-coding-rna-linc00238-suppresses-the-malignant-phenotype-of-liver-cancer-by-sponging-mir%C3%A2-522
#39
Hong-Gang Qian, Qiong Wu, Jian-Hui Wu, Xiu-Yun Tian, Wei Xu, Chun-Yi Hao
Subsequently to the publication of the above article, an interested reader drew to the authors' attention that two pairs of data panels featured in Figs. 2E and 6D, portraying the results from cell invasion and migration assay experiments, appeared to contain overlapping sections, such that data which were intended to show the results from differently performed experiments had apparently been derived from a smaller number of original sources. The authors were able to re‑examine their original data (which was also presented to the Editorial Office), and realized that errors has been made in the compilation of Fig...
April 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38426545/senp1-attenuates-hypoxia%C3%A2-reoxygenation-injury-in-liver-sinusoid-endothelial-cells-by-relying-on-the-hif%C3%A2-1%C3%AE-signaling-pathway
#40
JOURNAL ARTICLE
Zhe Qing, Qun Luo, Jian Duan, Jie Lin, Hanfei Huang, Shikun Yang, Zhong Zeng
Liver sinusoidal endothelial cells (LSECs) have an important role in hepatic ischemia‑reperfusion injury (I/R), but the specific molecular mechanism of action is unknown. LSEC proliferation is regulated and fenestration is maintained via the Sentrin/SUMO‑specific protease 1 (SENP1)/hypoxia‑inducible factor‑1α (HIF‑1α) signaling axis under hypoxic conditions. In the present study, a hypoxia‑reoxygenation (H‑R) injury model was established using mouse LSECs to explore the relationship between SENP1 and H‑R injury in vitro , and the specific underlying mechanism was identified, revealing new targets for the clinical attenuation of hepatic I/R injury...
April 2024: Molecular Medicine Reports
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