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Molecular Medicine Reports

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https://www.readbyqxmd.com/read/29956812/parathyroid-hormone-1%C3%A2-34-inhibits-senescence-in-rat-nucleus-pulposus-cells-by-activating-autophagy-via-the-m%C3%A2-tor-pathway
#1
Xiao-Ying Wang, Li-Yan Jiao, Jing-Lan He, Zhi-An Fu, Ru-Jun Guo
Osteoporosis is closely associated with intervertebral disc degeneration. While parathyroid hormone (PTH) 1‑34, which is an established drug used to treatosteoporosis, is thought to inhibit the disc degeneration associated with osteoporosis, the precise mechanism involved remains unclear. In the present study, primary Sprague‑Dawley rat nucleus pulposus cells (NPCs) were cultured, phenotyped and then treated with dexamethasone (DXM) for 48 h. Cell area analysis and β‑galactosidase staining were used to investigate the effect of DXM on the senescence of NPCs...
June 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956806/decreased-expression-of-troap-suppresses-cellular-proliferation-migration-and-invasion-in-gastric-cancer
#2
Ke Jing, Qinsheng Mao, Peng Ma
Trophinin associated protein (TROAP) is a cytoplasmic protein required for spindle assembly and cell invasion; however, its biological function in cancer remains to be elucidated. In the present study, by analyzing three independent datasets from the Oncomine database, it was identified that TROAP mRNA expression was upregulated in gastric cancer (GC) tissues compared with normal counterparts. Furthermore, elevated expression of TROAP was associated with poor survival in patients with GC, as predicted using Kaplan‑Meier analysis...
June 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956788/comparison-of-target-volume-and-clinical-effects-of-four-radiotherapy-plans-for-acute-lymphoblastic-leukemia-prior-to-hematopoietic-stem-cell-transplantation
#3
Yalei Lin, Fanyang Kong, Hongfei Li, Dandan Xu, Fei Jia, Xudong Zhang, Baohong Wang, Guowen Li
The present study aimed to investigate the variations in target volume, clinical reaction and transplantation effects of helical tomotherapy (HT)‑total body irradiation (TBI), HT‑total marrow and lymphatic irradiation (TMLI), intensity modulated radiotherapy (IMRT)‑TBI and IMRT‑TMLI within patients with acute lymphoblastic leukemia (ALL). A total of 18 patients with ALL were treated with the four aforementioned radiotherapy plans prior to hematopoietic stem cell transplantation. A planned prescribed dose of 12 Gy/6 Frequency was administered to determine planning target volume (PTV)...
June 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956801/tanshinone-iia-improves-hypoxic-ischemic-encephalopathy-through-tlr%C3%A2-4%C3%A2-mediated-nf%C3%A2-%C3%AE%C2%BAb-signal-pathway
#4
Chengzhi Fang, Lili Xie, Chunmei Liu, Chunhua Fu, Wei Ye, Hong Liu, Binghong Zhang
Hypoxic ischemic encephalopathy (HIE) is the most common brain injury following hypoxia and/or ischemia caused by various factors during the perinatal period, resulting in detrimental neurological deficits in the nervous system. Tanshinone IIA (Tan‑IIA) is a potential agent for the treatment of cardiovascular and cerebrovascular diseases. In this study, the efficacy of Tan‑IIA was investigated in a newborn mouse model of HIE. The dynamic mechanism of Tan‑IIA was also investigated in the central nervous system of neonate mice...
June 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956800/interaction-with-adipocytes-induces-lung-adenocarcinoma-a549-cell-migration-and-tumor-growth
#5
Fan-Fan Li, Hang Zhang, Jing-Jing Li, Ya-Nan Cao, Xiang Dong, Cong Gao
Adipocytes have been demonstrated to promote the progression of various tumors through modulation of cancer cell metabolism. However, their role in lung cancer progression remains undetermined. In the present study, adipocytes and lung adenocarcinoma A549 cells were cultured in a Transwell co‑culture system. Cancer cells were additionally cultured in conditioned medium, obtained from adipocytes or co‑cultured cells. A MTT and colony formation assay were performed to assess A549 cell proliferation. The expression of epithelial‑mesenchymal transition protein markers E‑cadherin and vimentin were measured by western blotting...
June 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956799/effects-of-constrained-dynamic-loading-ckip%C3%A2-1-gene-knockout-and-combination-stimulations-on-bone-loss-caused-by-mechanical-unloading
#6
Biao Han, Shu-Ping Wei, Xin-Chang Zhang, Hao Li, Yu Li, Rui-Xin Li, Kairen Li, Xi-Zheng Zhang
Mechanical stimulation plays an important role in maintaining the growth and normal function of the skeletal system. Mechanical unloading occurs, for example, in astronauts spending long periods of time in space or in patients on prolonged bed rest, and causes a rapid loss of bone mass. Casein kinase 2‑interacting protein‑1 (CKIP‑1) is a novel negative bone regulation factor that has been demonstrated to reduce bone loss and enhance bone formation. The aim of this study was to investigate the effect of constrained dynamic loading (Loading) in combination with CKIP‑1 gene knockout (KO) on unloading‑induced bone loss in tail‑suspension mice...
June 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956796/label%C3%A2-free-quantitative-proteomics-and-bioinformatics-analyses-of-alcoholic-liver-disease-in-a-chronic-and-binge-mouse-model
#7
Yu Zhang, Cheng Zhan, Genwen Chen, Jianyong Sun
As a significant cause of mortality and morbidity, alcoholic liver disease (ALD) has been widely investigated. However, little is known about the underlying metabolic mechanisms involved in the complicated pathological processes of ALD. The present study used label‑free quantitative proteomics and bioinformatics analyses to investigate the differentially expressed proteins (DEPs) and their functions in the livers of alcohol‑feed (AF) and control pair‑feed (PF) mice. As a result, 87 upregulated DEPs and 133 downregulated DEPs were identified in AF liver tissues compared with PF livers...
June 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956790/effects-of-isomaltulose-on-insulin-resistance-and-metabolites-in-patients-with-non%C3%A2-alcoholic-fatty-liver-disease-a-metabolomic-analysis
#8
Takumi Kawaguchi, Dan Nakano, Tetsuharu Oriishi, Takuji Torimura
Insulin resistance is associated with a poor prognosis in non‑alcoholic fatty liver disease (NAFLD) patients. Isomaltulose, a naturally‑occurring disaccharide, is reported to improve glucose and lipid metabolisms in obese patients. The present study aimed to investigate the effects of isomaltulose on insulin resistance and various metabolites in NAFLD patients. Five male patients with NAFLD consumed 20 g isomaltulose or sucrose (control). Changes in insulin resistance and metabolites were evaluated by alterations of serum C‑peptide immunoreactivity (CPR) and metabolomic analysis from baseline to 15 min after the administration, respectively...
June 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956789/timp%C3%A2-3-suppresses-the-proliferation-and-migration-of-smcs-from-the-aortic-neck-of-atherosclerotic-aaa-in-rabbits-via-decreased-mmp%C3%A2-2-and-mmp%C3%A2-9-activity-and-reduced-tnf%C3%A2-%C3%AE-expression
#9
Huan Zhai, Xun Qi, Zixuan Li, Wei Zhang, Chenguang Li, Lu Ji, Ke Xu, Hongshan Zhong
The present study investigated the role of tissue inhibitor of matrix metalloproteinase‑3 (TIMP‑3) in regulating the proliferation, migration, apoptosis and activity of matrix metalloproteinase (MMP)‑2 and ‑9, during the development of an atherosclerotic abdominal artery aneurysm (AAA). Experiments were conducted using rabbit AAA neck (NA) smooth muscle cells (SMCs), to investigate the potential for TIMP‑3 to be used as a novel stent coating in preventing aortic dilation adjacent to the AAA. The atherosclerotic AAA model was induced in New Zealand white rabbits via a 6‑week high‑cholesterol diet, followed by incubation of the targeted aortic region with elastase...
June 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956759/embelin-inhibits-abdominal-aortic-aneurysm-through-decreasing-il%C3%A2-6%C3%A2-induced-stat3-and-nf%C3%A2-%C3%AE%C2%BAb-inactivation
#10
Qiang Liu, Qingshan Wang, Haibin Li
The aim of the present study was to investigate the effect of embelin on abdominal aortic aneurysm (AAA). AAA model mice were induced by chronic infusion of 1,000 ng/kg/min Angiotensin II. AAA model mice were treated with 25, 50 or 100 mg/kg embelin for 28 days. Embelin inhibited tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6, IL‑18 and malondialdehyde (MDA) level activities, increased superoxide dismutase, glutathione (GSH) and GSH peroxidase level activities and inhibited MDA level activities in AAA mice Embelin suppressed the secretion of matrix metalloproteinase‑9 protein expression, monocyte chemoattractant protein‑2 activity and epithelial neutrophil‑activating peptide expression levels in AAA mice...
June 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956798/intraperitoneal-oxaliplatin-administration-inhibits-the-tumor-immunosuppressive-microenvironment-in-an-abdominal-implantation-model-of-colon-cancer
#11
Hong-Feng Gou, Lei Zhou, Jia Huang, Xin-Chuan Chen
Recent studies have demonstrated that some chemotherapeutic drugs can enhance antitumor immunity by eliminating and inactivating immunosuppressive cells. Oxaliplatin (OXP) induces immunogenic cell death by increasing the immunogenicity of cancer cells. However, the effects of OXP on the tumor immunosuppressive microenvironment remain unclear. The aim of the present study was to evaluate the antitumor activity of OXP by intraperitoneal (i.p.) administration in an abdominal implantation model of colon cancer and tested the tumor immune microenvironment to observe whether OXP affects the local immune inhibitory cell populations...
June 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956762/recombinant-club-cell-protein-16-cc16-ameliorates-cigarette-smoke%C3%A2-induced-lung-inflammation-in-a-murine-disease-model-of-copd
#12
Min Pang, Hong-Yan Liu, Ting Li, Dan Wang, Xiao-Yun Hu, Xin-Ri Zhang, Bao-Feng Yu, Rui Guo, Hai-Long Wang
Club cell protein (CC16) is expressed primarily by club cells possesses anti‑inflammatory properties and is located in the bronchiolar epithelium. Previous studies have demonstrated that CC16 deficiency is associated with the progression of chronic obstructive pulmonary disease (COPD). In the present study, the therapeutic effects of recombinant rat CC16 protein in mice with COPD were examined and the underlying mechanisms investigated. A total of 30 adult male C57/BL6 mice were randomly divided into three groups (10 mice/group)...
June 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956761/aclidinium-bromide-inhibits-the-growth-and-metastasis-of-gastric-cancer-mkn%C3%A2-28-cells-via-the-pi3k-signaling-pathway
#13
Yuanzhi Wang, Ping Cui, Jingjing Liu, Hongxia Wu, Jun Ma
The present study investigated the effect and underling mechanisms of aclidinium bromide, a novel, inhaled long‑acting muscarinic antagonist, on the development of gastric cancer. Human gastric cancer MKN‑28 cells, as a model in vitro, were treated with aclidinium bromide and dimethyl sulfoxide. Cell Counting Kit‑8 assay, transwell assay and flow cytometry were used to assess cell proliferation, invasion/migration and apoptosis, respectively. In addition, western blotting was performed to determine the relative expression of proteins associated with apoptosis and the phosphatidylinositol‑3‑kinase (PI3K) signaling pathway...
June 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956758/-corrigendum-differences-in-atrial-fibrillation%C3%A2-associated-proteins-between-the-left-and-right-atrial-appendages-from-patients-with-rheumatic-mitral-valve-disease-a-comparative-proteomic-analysis
#14
Hai Liu, Guangxian Chen, Hongsheng Zheng, Han Qin, Mengya Liang, Kangni Feng, Zhongkai Wu
Subsequently to the publication of this article, the authors have realized that an address affiliation associated with certain of the authors had been omitted. The authors' affiliation information should have appeared as follows (the omitted address affiliation is featured in bold): Hai Liu1-3*, Guangxian Chen1,2*, Hongsheng Zheng4*, Han Qin1,2, Mengya Liang1,2, Kangni Feng1,2 and Zhongkai Wu1,2 1Second Department of Cardiac Surgery, First Affiliated Hospital of Sun Yat-Sen University; 2Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong 510080; 3Third Department of Cardiac Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052; 4Department of Cardiac Surgery, Henan Provincial Chest Hospital, Zhengzhou, Henan 450008, P...
June 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956755/microrna-expression-profiles-identify-biomarkers-for-predicting-the-response-to-chemoradiotherapy-in-rectal-cancer
#15
Binbin Du, Xiaoying Wang, Dewang Wu, Tao Wang, Xiongfei Yang, Jiankai Wang, Xinlong Shi, Lingjuan Chen, Weisheng Zhang
Neoadjuvant chemoradiotherapy (nCRT) following surgery significantly improves the survival rate of patients with rectal cancer. However, nCRT is associated with significant adverse symptoms and high medical costs. Therefore, it is important to investigate potential biomarkers for the prediction of the response to nCRT in patients with rectal cancer. The present study identified candidate biomarkers for predicting a complete response (CR) to nCRT in patients with rectal cancer and investigated the associated mechanisms...
June 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956802/inhibition-of-autophagy-enhanced-cobalt-chloride%C3%A2-induced-apoptosis-in-rat-alveolar-type-ii-epithelial-cells
#16
Yan Yu, Wanting Li, Liqin Ren, Chunyan Yang, Dongze Li, Xin Han, Yeying Sun, Changjun Lv, Fang Han
Hypoxia is a type of cellular stress that may result in apoptosis and autophagy. The molecular mechanisms underlying the association between autophagy and apoptosis remain unclear, particularly in hypoxic conditions. Transmission electron microscope, AO‑PI staining, flow cytometry and western blot were used to examine the crosstalk between autophagy and apoptosis in hypoxic conditions. Rat alveolar type II epithelial RLE‑6TN cells were cultured in a long‑term hypoxic environment established by cobalt (II) chloride...
June 22, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956791/the-close-association-between-il%C3%A2-12r%C3%AE-2-and-p38mapk-and-higher-expression-in-the-early-stages-of-nsclc-indicates-a-good-prognosis-for-survival
#17
Zhaoguo Liu, Weilin Yang, Shibin Yang, Kaican Cai
Interleukin‑12 receptor (IL‑12R) and p38 mitogen‑activated protein kinase (p38MAPK) serve an important role in non‑small cell lung cancer (NSCLC). It has previously been suggested that IL‑12Rβ2 may be involved in key regulatory pathways and interacts with the p38MAPK signaling pathway. The present study aimed to elucidate the possible association and roles of IL‑12Rβ2 and p38MAPK in NSCLC. The protein expression levels of IL‑12Rβ2 and p38MAPK were measured in 230 NSCLC tissue samples by immunohistochemistry (IHC) and western blot analyses...
June 22, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956785/bm%C3%A2-mscs-protect-against-liver-ischemia-reperfusion-injury-via-ho%C3%A2-1-mediated-autophagy
#18
Xun Wang, Shuai Wang, Yuan Zhou, Halmurat Obulkasim, Zhi-Heng Zhang, Bo Dai, Wei Zhu, Xiao-Lei Shi
Ischemia/reperfusion (I/R) injury is considered to be a contributing factor in liver injury following major hepatic resection or liver transplantation. Bone marrow mesenchymal stem cells (BM‑MSCs) have the potential to protect against liver I/R injury; however, the precise mechanisms have not been completely elucidated. Autophagy serves an important role in protecting against various injuries, including I/R injury. The present study aimed to determine the role of autophagy and its potential regulatory mechanism in BM‑MSC‑mediated protection against liver I/R injury in rats...
June 22, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956783/next%C3%A2-generation-sequencing%C3%A2-based-detection-of-egfr-kras-braf-nras-pik3ca-her%C3%A2-2-and-tp53-mutations-in-patients-with-non%C3%A2-small-cell-lung-cancer
#19
Changwen Jing, Xuhua Mao, Zhuo Wang, Kejing Sun, Rong Ma, Jianzhong Wu, Haixia Cao
In recent years, the incidence of non‑small cell lung cancer (NSCLC) has become the highest lethal rate of cancer worldwide. Molecular assays of EGFR, KRAS, BRAF, NRAS, PIK3CA and Her‑2 are widely used to guide individualized treatment in NSCLC patients. Somatic mutations in 112 NSCLC patients, including 7 oncogenic driver genes, were detected by Iontorrent personal genome machine (PGM). Sanger sequencing was used to test and verify the results of PGM. Apart from uncommon mutations of EGFR, 101 NSCLC specimens were tested by droplet digital PCR (ddPCR)...
June 22, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29956782/c5a-aggravates-dysfunction-of-the-articular-cartilage-and-synovial-fluid-in-rats-with-knee-joint-immobilization
#20
Wei Lu, Lin Wang, Jing Yao, Chunxin Wo, Yu Chen
Degenerative alterations in articular cartilage are involved in the pathogenesis of osteoarthritis. The present study aimed to evaluate the role of complement component 5a (C5a) in osteoarthritic alterations in the articular cartilage and synovialis via a joint immobilization (IM) rat model. Rats were assigned to three groups: Control, IM and IM+anti‑C5a antibody (IM+anti‑C5a) groups. A terminal deoxynucleotidyl transferase dUTP nick end labeling assay and hematoxylin and eosin staining were used to evaluate the morphological alterations in the articular cartilage and synovialis...
June 22, 2018: Molecular Medicine Reports
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