journal
MENU ▼
Read by QxMD icon Read
search

Journal of Aerosol Medicine and Pulmonary Drug Delivery

journal
https://www.readbyqxmd.com/read/30335559/an-open-label-study-evaluating-the-performance-of-the-dose-indicator-in-a-metered-dose-inhaler-delivering-glycopyrrolate-and-formoterol-fumarate-in-patients-with-moderate-to-very-severe-chronic-obstructive-pulmonary-disease
#1
Krishna Pudi, Gregory Feldman, Faisal Fakih, Peter Mack, Andrea Maes, Shahid Siddiqui, Earl St Rose, Colin Reisner
BACKGROUND: GFF MDI is a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler formulated using co-suspension delivery technology. This open-label, single-arm multicenter study (NCT02268396) evaluated the accuracy, reliability, and functionality of the GFF MDI AeroCount® dose indicator when used by patients with chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: The study enrolled subjects (40-80 years of age) with an established clinical history (≥6 months) of COPD, who completed an electronic diary twice daily to record study-drug administration time, the number of actuations used, and pre- and post-dose dose indicator readings...
November 1, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/30376396/radiolabeling-an-electronic-cigarette-aerosol-using-technetium-carbon-ultrafine-particles
#2
Landon T Holbrook, Kirby L Zeman, Alyssa Burke, Ilona Jaspers, William D Bennett
BACKGROUND: Electronic cigarettes (ECIGs) are widely used, but their health effects are not well known. ECIG exposure is difficult to quantify, and a direct measurement of deposition would be beneficial to in vivo and in vitro toxicity studies. The aim of this study was to demonstrate effective radiolabeling of an ECIG. METHODS: A technetium-99m-labeled carbon ultrafine (TCU) aerosol was generated and introduced to a fourth-generation ECIG before nucleation and aerosol formation...
October 30, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/30359162/pharmacokinetic-profile-of-inhaled-submicron-particle-paclitaxel-nanopac-%C3%A2-in-a-rodent-model
#3
James Verco, William Johnston, Michael Baltezor, Philip J Kuehl, Andrew Gigliotti, Steven A Belinsky, Anita Lopez, Ronald Wolff, Lauren Hylle, Gere diZerega
BACKGROUND: Inhaled chemotherapeutics may enhance pulmonary drug exposure to malignant lesions in the lung without substantially contributing to systemic toxicities. The pharmacokinetic profile of inhaled submicron particle paclitaxel (NanoPac® ) in healthy rodent plasma and lung tissue is evaluated here to determine administration proof-of-principle. METHODS: Healthy male Sprague Dawley rats received paclitaxel in one of three arms: intravenous nab-paclitaxel at 2...
October 25, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/30339061/natural-derived-surfactant-preparation-as-a-carrier-of-polymyxin-e-for-treatment-of-pseudomonas-aeruginosa-pneumonia-in-a-near-term-rabbit-model
#4
Oihana Basabe-Burgos, Jakub Zebialowicz, Guido Stichtenoth, Tore Curstedt, Peter Bergman, Jan Johansson, Anna Rising
BACKGROUND: Pulmonary surfactant spreads rapidly over the airway epithelium, a property that could be harnessed to transport drugs into the lungs. For efficient drug delivery, an interaction between pulmonary surfactant and the drug to be administered is likely needed. On the other hand, the interaction should not compromise the activity of surfactant or the drug once delivered in vivo. The antibiotics gentamicin (an aminoglycoside) and polymyxin E represent drugs that could benefit from being delivered directly to the lung, thereby increasing local concentrations and reducing systemic side effects...
October 19, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/30300557/in-vitro-flow-rate-dependency-of-delivered-dose-and-fine-particle-dose-of-salmeterol-fluticasone-propionate-easyhaler-and-seretide-diskus-with-patient-flow-rates-collected-in-a-randomized-controlled-trial
#5
Rain Jõgi, Satu Lähelmä, Mikko Vahteristo, Anita Happonen, Jussi Haikarainen
BACKGROUND: The Easyhaler® device-metered dry powder inhaler containing Salmeterol and Fluticasone propionate (S/F) has been developed for the treatment of patients with asthma and chronic obstructive pulmonary disease (COPD). We report two studies which evaluated the in vitro flow rate dependence of delivered dose (DD) and fine particle dose (FPD) of S/F Easyhaler versus Seretide Diskus® . METHODS: A randomized controlled trial (RCT) assessed inspiratory flow parameters of S/F Easyhaler and Seretide Diskus in subgroups of patients with asthma (children, adolescents and adults, and elderly) and in COPD patients...
October 9, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/30199315/intranasal-filtration-of-inhaled-aerosol-in-human-subjects-as-a-function-of-nasal-pressure-drop
#6
Laleh Golshahi, Sana Hosseini
BACKGROUND: Intersubject variability in nasal deposition of inhaled aerosol is significant because of the differences in nasal anatomy and breathing rate. The notable limitation of the majority of previously developed predictive correlations is including a limited number of subjects. A few recent studies have considered a wide age range of subjects, but the resulting correlations require the knowledge of the dimensions of the nasal airways and the properties of inhaled gas. In this study empirical correlations are proposed to predict aerosol deposition in nasal airways of subjects of different age as a function of intranasal pressure drop and the particle aerodynamic diameter...
September 10, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/30199313/effect-of-nebulizer-location-and-spontaneous-breathing-on-aerosol-delivery-during-airway-pressure-release-ventilation-in-bench-testing
#7
Hui-Qing Ge, Ji-Mei Wang, Hui-Ling Lin, James B Fink, Ronghua Luo, Peifeng Xu, Kejing Ying
BACKGROUND: Airway pressure release ventilation (APRV) maintains a sustained airway pressure over a large proportion of the respiratory cycle, and has a long inspiratory time at high pressure. The purpose of this study was to determine the influence of the APRV with and without spontaneous breathing on albuterol aerosol delivery with a continuous vibrating-mesh nebulizer (VMN) placed at different positions on an adult lung model of invasive mechanical ventilation. METHODS: An adult lung model was assembled by connecting a ventilator with a dual-limb circuit to an 8-mm inner diameter endotracheal tube (ETT) and collecting filter attached to a test lung with set compliance of 0...
September 8, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29989511/lung-deposition-of-the-dry-powder-fixed-combination-beclometasone-dipropionate-plus-formoterol-fumarate-using-nexthaler-%C3%A2-device-in-healthy-subjects-asthmatic-patients-and-copd-patients
#8
Johann Christian Virchow, Gianluigi Poli, Christiane Herpich, Claudius Kietzig, Hilke Ehlich, Daniela Braeutigam, Knut Sommerer, Sabine Häussermann, Fabrizia Mariotti
BACKGROUND: This study evaluated the lung deposition and the distribution pattern in the airways of a fixed combination of beclometasone dipropionate (BDP) and formoterol fumarate (FF) (100/6 μg) delivered as an extrafine dry powder formulation (mass median aerodynamic diameter, MMAD (μm) BDP = 1.5; FF = 1.4) through the NEXThaler® device in healthy subjects, asthmatics, and patients with COPD. METHODS: Healthy subjects (n = 10), asthmatic patients (n = 9; 30%≤FEV1 < 80%), and COPD patients (n = 9; FEV1 /FVC ≤70%, 30%≤FEV1 < 50%) completed this open-label, single administration (inhalation of four actuations) parallel group study...
October 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29878856/impact-of-hypertonic-saline-solutions-on-sputum-expectoration-and-their-safety-profile-in-patients-with-bronchiectasis-a-randomized-crossover-trial
#9
Beatriz Herrero-Cortina, Victoria Alcaraz, Jordi Vilaró, Antoni Torres, Eva Polverino
BACKGROUND: The role of hyaluronic acid plus hypertonic saline (HA+HS) as a mucoactive treatment in patients with bronchiectasis is still unknown. This study evaluated whether HA+HS solution enhances similar sputum quantity with better safety profile than HS alone in patients with bronchiectasis. METHODS: In this double-blind randomized crossover trial, three solutions (7% HS; 0.1% HA +7%HS; and 0.9% isotonic saline, IS) were compared in outpatients with bronchiectasis and chronic sputum expectoration...
October 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29812991/should-inhaler-prescriptions-also-recommend-watching-videos-showing-how-to-use-inhaling-devices-properly
#10
Bruno Sposato
No abstract text is available yet for this article.
October 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29672215/anatomically-based-analysis-of-radioaerosol-distribution-in-pulmonary-scintigraphy-a-feasibility-study-in-asthmatics
#11
Luciana Alcoforado, Armèle Dornelas de Andrade, Joaquin L Herraiz, Simone Cristina Soares Brandão, Jacqueline de Melo Barcelar, James B Fink, Jose G Venegas
INTRODUCTION: Manual analysis of two-dimensional (2D) scintigraphy to evaluate aerosol deposition is usually subjective and has reduced sensitivity to quantify regional differences between central and distal airways. AIMS: (1) To present a method to analyze 2D scans based on three-dimensional (3D)-linked anatomically consistent regions of interest (ROIs); (2) to evaluate peripheral-to-central counts ratio (P/C2D ) and penetration indices (PIs) for a set of 16 subjects with moderate-to-severe asthma; and (3) to compare the reproducibility of this method against one with manually traced ROIs...
October 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29641361/aerosolization-of-zn-dtpa-decorporation-agent-using-jet-and-ultrasonic-nebulizers
#12
Rym Mehri, Weiquan Tang, Edgar A Matida, Edward P C Lai
BACKGROUND: Chelating agents such as diethylenetriamine pentaacetic acid (DTPA) can be used as a decorporation drug in the zinc (Zn) form to treat internal radioactive contamination after exposure to plutonium or americium in a nuclear accident. Although Zn-DTPA is normally administered intravenously, inhalation of Zn-DTPA in aerosol form is a better route for direct delivery to the lungs. This work investigates the feasibility of synthesizing Zn-DTPA from three common chemicals and aerosolizing it using a jet or ultrasonic nebulizer...
October 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29493402/pharmacokinetics-of-salmeterol-and-fluticasone-propionate-delivered-in-combination-via-easyhaler-and-diskus-dry-powder-inhalers-in-healthy-subjects
#13
Merja Kirjavainen, Leena Mattila, Mikko Vahteristo, Jani Korhonen, Satu Lähelmä
BACKGROUND: Easyhaler® dry powder inhaler (DPI) containing salmeterol and fluticasone propionate was developed for the treatment of asthma and chronic obstructive pulmonary disease. Three different Salmeterol/fluticasone Easyhaler test products (Orion Pharma, Finland) were compared against the reference product Seretide® Diskus® DPI (GlaxoSmithKline, United Kingdom) to study whether any of the test products are bioequivalent with the reference. METHODS: Open and randomized pharmacokinetic four-period crossover study on 65 healthy volunteers was performed in a single center to compare the lung deposition and total systemic exposure of salmeterol and fluticasone propionate after administration of single doses (two inhalations of 50/500 μg/inhalation strength) in fasting conditions...
October 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29979636/re-harmonizing-the-nomenclature-for-therapeutic-aerosol-particle-size-a-proposal-by-hillyer-et-al-j-aerosol-med-pulm-drug-deliv-2018-31-2-111-113-doi-10-1089-jamp-2017-1396
#14
Myrna B Dolovich, Jolyon P Mitchell, Daryl L Roberts
No abstract text is available yet for this article.
August 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29261454/development-of-an-inline-dry-powder-inhaler-that-requires-low-air-volume
#15
Dale Farkas, Michael Hindle, P Worth Longest
BACKGROUND: Inline dry powder inhalers (DPIs) are actuated by an external air source and have distinct advantages for delivering aerosols to infants and children, and to individuals with compromised lung function or who require ventilator support. However, current inline DPIs either perform poorly, are difficult to operate, and/or require large volumes (∼1 L) of air. The objective of this study was to develop and characterize a new inline DPI for aerosolizing spray-dried formulations with powder masses of 10 mg and higher using a dispersion air volume of 10 mL per actuation that is easy to load (capsule-based) and operate...
August 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29261402/oral-versus-nasal-high-flow-bronchodilator-inhalation-in-chronic-obstructive-pulmonary-disease
#16
Jens Bräunlich, Hubert Wirtz
BACKGROUND: Nasal high flow (NHF) alters breathing patterns, stabilizes fraction of inspired oxygen (FiO2) during respiratory distress, helps to keep up hemostasis in the airways, and washes out the upper airways. Particularly the support of inspiratory flow and decrease in functional dead space are interesting mechanisms of action with regard to aerosol delivery. Several laboratory investigations have studied aerosol delivery via the nasal route by using NHF, whereas clinical benefits are poorly evaluated...
August 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29206566/preferences-and-inhalation-techniques-for-inhaler-devices-used-by-patients-with-chronic-obstructive-pulmonary-disease
#17
Roxanne Bournival, Raphaël Coutu, Nicolas Goettel, Chun Dian Yang, Antoine Cantin-Lafleur, Catherine Lemieux, Anne-Marie Lévesque, Jean-François Patenaude-Monette, François-Olivier Roy, Lucie Blais, Fanny Arbour, Anne Fillion, Marie-France Beauchesne
BACKGROUND: Inhaler technique and patient preferences are often overlooked when selecting maintenance treatments for patients with chronic obstructive pulmonary disease (COPD), but are important issues in ensuring drug efficacy and patient adherence. Few data on these issues are available for new inhalation devices. OBJECTIVES: To evaluate the inhalation techniques for the HandiHaler® , Breezhaler® , Genuair® , and Respimat® inhalation devices, and patient preferences for the three latter inhalers that were recently developed...
August 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29125912/an-in-vitro-examination-of-the-effects-of-altitude-on-dry-powder-inhaler-performance
#18
Conor A Ruzycki, Andrew R Martin, Reinhard Vehring, Warren H Finlay
BACKGROUND: The effects of altitude on dry powder inhaler (DPI) performance remain understudied. As existing standardized testing methodologies do not consider altitude, inhalation devices may be used in environments in which their performance has not been sufficiently characterized. METHODS: Six DPIs spanning a range of device resistances were examined in vitro in an environmental chamber mimicking a high-altitude environment equivalent to an altitude of 4200 m, with controls established at an altitude of 700 m...
August 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29090973/highlights-from-the-2017-ipac-rs-isam-joint-workshop-new-frontiers-in-inhalation-technology
#19
Hugh D Smyth, Paul Colthorpe, Maureen George, Paul Jansen, Anders Fuglsang, Katherine E Armstrong, Svetlana Lyapustina
No abstract text is available yet for this article.
August 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29053080/aerosolizing-lipid-dispersions-enables-antibiotic-transport-across-mimics-of-the-lung-airway-surface-even-in-the-presence-of-pre-existing-lipid-monolayers
#20
Steven V Iasella, Amy Z Stetten, Timothy E Corcoran, Stephen Garoff, Todd M Przybycien, Robert D Tilton
BACKGROUND: Secondary lung infections are the primary cause of morbidity associated with cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but has limited effectiveness due to altered airway aerodynamics and deposition patterns that limit drug access to infected regions. One potential strategy to better reach infected areas is to formulate aerosols with surfactants that induce surface tension gradients and drive postdeposition drug dispersal via Marangoni transport along the airway surface liquid (ASL)...
August 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
journal
journal
42009
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"