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Journal of Aerosol Medicine and Pulmonary Drug Delivery

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https://www.readbyqxmd.com/read/28520510/abstracts-from-the-aerosol-society-drug-delivery-to-the-lungs-27-edinburgh-international-conference-centre-edinburgh-scotland-uk-december-7-9-2016
#1
(no author information available yet)
No abstract text is available yet for this article.
May 18, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28510491/short-term-growth-during-treatment-with-inhaled-fluticasone-propionate-formoterol-fluticasone-and-beclomethasone-treatment
#2
Ole D Wolthers, Ainslee Moore, Sabine Mersmann, Sanjeeva Dissanayake
BACKGROUND: Fluticasone propionate/formoterol (FP/FORM) is a pressurized metered-dose inhaler (pMDI; Flutiform(®)) approved for use in adolescents and adults and under development for pediatric use. OBJECTIVE: To compare short-term growth in asthmatic children treated with FP/FORM, FP pMDI with valved holding chamber, and beclomethasone dipropionate (BDP) in a breath-actuated device. METHODS: Children with persistent asthma (n = 48; 5 to <12 years) participated in an assessor-blinded, randomized, three-way crossover trial with run in, wash out, and active treatment periods, each of 2 weeks duration...
May 16, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28510480/dry-powder-inhaler-formulation-of-rifampicin-an-improved-targeted-delivery-system-for-alveolar-tuberculosis
#3
Tejal Rawal, Laurent Kremer, Iman Halloum, Shital Butani
BACKGROUND: The delivery of antitubercular drugs through direct lung targeting can lead to reduction in the dose as well as side effects of the drug. In the present investigation, carrier (lactose)-based dry-powder inhaler of rifampicin was prepared to achieve direct targeting of the drug into the lungs. METHODS: The dry powder inhaler formulation was prepared by simply mixing micronized rifampicin with coarse and fine lactose preblend. Preliminary blends of the drug were prepared with various lactose grades (Inhalac(®), Respitose,(®) and Lactohale(®))...
May 16, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28463044/aerosol-delivery-with-two-nebulizers-through-high-flow-nasal-cannula-a-randomized-cross-over-single-photon-emission-computed-tomography-computed-tomography-study
#4
Jonathan Dugernier, Michel Hesse, Thibaud Jumetz, Emilie Bialais, Jean Roeseler, Virginie Depoortere, Jean-Bernard Michotte, Xavier Wittebole, Stephan Ehrmann, Pierre-François Laterre, François Jamar, Gregory Reychler
BACKGROUND: High-flow nasal cannula use is developing in ICUs. The aim of this study was to compare aerosol efficiency by using two nebulizers through a high-flow nasal cannula: the most commonly used jet nebulizer (JN) and a more efficient vibrating-mesh nebulizer (VN). METHODS: Aerosol delivery of diethylenetriaminepentaacetic acid labeled with technetium-99m (4 mCi/4 mL) to the lungs by using a VN (Aerogen Solo(®); Aerogen Ltd., Galway, Ireland) and a constant-output JN (Opti-Mist Plus Nebulizer(®); ConvaTec, Bridgewater, NJ) through a high-flow nasal cannula (Optiflow(®); Fisher & Paykel, New Zealand) was compared in six healthy subjects...
May 2, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28463041/effect-of-pressurized-metered-dose-inhaler-spray-characteristics-and-particle-size-distribution-on-drug-delivery-efficiency
#5
Morteza Yousefi, Kiao Inthavong, Jiyuan Tu
BACKGROUND: A key issue in pulmonary drug delivery is improvement of the delivery device for effective and targeted treatment. Pressurized metered dose inhalers (pMDIs) are the most popular aerosol therapy device for treating lung diseases. This article studies the effect of spray characteristics: injection velocity, spray cone angle, particle size distribution (PSD), and its mass median aerodynamic diameter (MMAD) on drug delivery. METHODS: An idealized oral airway geometry, extending from mouth to the main bronchus, was connected to a pMDI device...
May 2, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28463040/pharmacokinetic-comparison-of-a-unit-dose-dry-powder-inhaler-with-a-multidose-dry-powder-inhaler-for-delivery-of-fluticasone-furoate
#6
Rashmi Mehta, Alison Moore, Kylie Riddell, Shashidhar Joshi, Robert Chan
BACKGROUND: The unit dose dry powder inhaler (UD-DPI) is being considered as an alternative inhaler platform that, if developed, has the potential to improve access to inhaled respiratory medicines in developing countries. AIM: This study compared the systemic exposure of fluticasone furoate after delivery from the UD-DPI with that from the ELLIPTA(®) inhaler. METHODS: This open-label, five-way cross-over, randomized, single-dose study in healthy subjects evaluated fluticasone furoate systemic exposure of three dose strengths (using four inhalations), 4 × 80 μg [320 μg], 4 × 100 μg [400 μg], and 4 × 140 μg [560 μg]), and two percentages of drug in lactose blends (0...
May 2, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28504922/abstracts-international-society-for-aerosols-in-medicine-e-v-21st-isam-congress-santa-fe-nm-june-3-7-2017
#7
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28418758/inhaled-heparin-therapeutic-efficacy-and-recent-formulations
#8
Ayca Yildiz-Pekoz, Yildiz Ozsoy
Heparin is well known for its anticoagulant and anti-inflammatory properties. Inhaled heparin regimens are increasingly being used to manage lung disease. It has been used to treat cystic fibrosis, thromboembolism, and pulmonary fibrosis, as well as bronchial asthma and asthma-induced airway hypersensitivity. Several preclinical studies attained some useful effects of heparin-administered, parenterally and through inhalation, treatment of lung disease. Besides, recent clinical trials suggest that inhaled heparin for lung diseases is beneficial and safe, but such data remain to be limited...
June 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28170282/pharmacokinetics-of-salbutamol-delivered-from-the-unit-dose-dry-powder-inhaler-comparison-with-the-metered-dose-inhaler-and-diskus-dry-powder-inhaler
#9
Alison Moore, Kylie Riddell, Shashidhar Joshi, Robert Chan, Rashmi Mehta
AIM: To compare the systemic exposure of salbutamol following delivery from the unit dose dry powder inhaler (UD-DPI) system with that from the Diskus(®) and metered dose inhaler (MDI). MATERIALS AND METHODS: This open-label, two-part, six-way crossover, randomized single-dose study in healthy subjects evaluated salbutamol systemic exposure of three dose strengths (using three inhalations: 3 × 150 μg [450 μg], 3 × 200 μg [600 μg], and 3 × 250 μg [750 μg]) and 2% of drug in lactose blends (1...
June 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28075194/aerosol-drug-delivery-during-noninvasive-positive-pressure-ventilation-effects-of-intersubject-variability-and-excipient-enhanced-growth
#10
Ross L Walenga, P Worth Longest, Anubhav Kaviratna, Michael Hindle
BACKGROUND: Nebulized aerosol drug delivery during the administration of noninvasive positive pressure ventilation (NPPV) is commonly implemented. While studies have shown improved patient outcomes for this therapeutic approach, aerosol delivery efficiency is reported to be low with high variability in lung-deposited dose. Excipient enhanced growth (EEG) aerosol delivery is a newly proposed technique that may improve drug delivery efficiency and reduce intersubject aerosol delivery variability when coupled with NPPV...
June 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28075182/dispersing-the-mists-an-experimental-history-of-medicine-study-into-the-quality-of-volatile-inhalations
#11
Barry Murnane, Cathal T Gallagher, Noel Snell, Mark Sanders, Ramin Moshksar, Darragh Murnane
BACKGROUND: Dr. Nelson's Improved Inhaler was first marketed with an advertisement in The Lancet in 1865. Revolutionary at the time for its ease of use and patient-friendliness, the inhaler is still in use for self-treatment by many all over the world. On the occasion of its 150th anniversary, this study reports an experimental historical medicine approach to identify evidence for the quality of vapor inhalers. METHODS: Through accessing reviews of the device's use by the contemporary medical establishment, it was established that Dr...
June 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27977309/drug-delivery-in-asthmatic-children-following-coordinated-and-uncoordinated-inhalation-maneuvers-a-randomized-crossover-trial
#12
Ariel Berlinski, Dirk von Hollen, Ross H M Hatley, Lucy E A Hardaker, Kurt Nikander
BACKGROUND: Valved holding chambers (VHCs) are used in children to deliver pressurized metered dose inhalers (pMDI). In vitro data suggest that uncoordinated use decreases the amount of drug available for inhalation. We hypothesize that in an ex vivo study, the coordinated maneuver will deliver more drug than the uncoordinated one. PATIENTS AND METHODS: Thirty-two clinically stable asthmatic children, ages 5-8 years, completed the study. An aerosol filter was interposed between a small-volume nonelectrostatic VHC and a mouthpiece to capture the drug emitted by one puff of Flovent(®) 220 mcg during tidal breathing...
June 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27849432/monitoring-the-inhalation-flow-rate-of-nebulized-aerosols-using-an-ultrasonic-flow-meter-in-vitro-assessment
#13
Michael Y Yang, Hak-Kim Chan
BACKGROUND: The measurement of aerosol flow rates without obscuration of the flow is of particular concern with in vivo lung deposition studies, where precise knowledge of aerosol particle size distributions is a necessary requirement for the development of predictive correlations. This study examines the utility of an ultrasonic flow meter for such measurements and determines if a valved system can be attached to the flow meter for sampling exhaled aerosols. METHODS: The flow rate across a D-30 flow meter was compared with and without nebulization of 0...
June 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27977321/comparative-study-on-the-size-distributions-respiratory-deposition-and-transport-of-particles-generated-from-commonly-used-medical-nebulizers
#14
Yang Wang, Jiayu Li, Anna Leavey, Caroline O'Neil, Hilary M Babcock, Pratim Biswas
BACKGROUND: Medical nebulizers are widely and conveniently used to deliver medication to the lungs as an inhalable mist; however, the deposition of nebulized particles in the human respiratory system and the transport of the nebulized particles in the environment have not been studied in detail. METHODS: Five medical nebulizers of three different types (constant output, breath enhanced, and dosimetric) were evaluated. The size distribution functions (SDFs) and respiratory deposition of the particles generated from the nebulizers were characterized...
April 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27977318/nebulized-recombinant-human-tissue-factor-pathway-inhibitor-attenuates-coagulation-and-exerts-modest-anti-inflammatory-effects-in-rat-models-of-lung-injury
#15
Florry E van den Boogaard, Jorrit J Hofstra, Xanthe Brands, Marcel M Levi, Joris J T H Roelofs, Sebastiaan A J Zaat, Cornelis Van't Veer, Tom van der Poll, Marcus J Schultz
BACKGROUND: Critically ill patients are at a constant risk of direct (e.g., by pneumonia) or indirect lung injury (e.g., by sepsis). Excessive alveolar fibrin deposition is a prominent feature of lung injury, undermining pulmonary integrity and function. METHODS: We examined the effect of local administration of recombinant human tissue factor pathway inhibitor (rh-TFPI), a natural anticoagulant, in two well-established models of lung injury in rats. Rats received intratracheal instillation of Pseudomonas aeruginosa, causing direct lung injury, or they received an intravenous injection of Escherichia coli lipopolysaccharide (LPS), causing indirect lung injury...
April 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27977306/nasal-and-olfactory-deposition-with-normal-and-bidirectional-intranasal-delivery-techniques-in-vitro-tests-and-numerical-simulations
#16
Jinxiang Xi, Zhaoxuan Wang, Danielle Nevorski, Thomas White, Yue Zhou
BACKGROUND: Intranasal delivery protocols that can effectively deposit drugs to the olfactory region are severely lacking. Furthermore, it is still challenging to quantify nasal deposition on a regional or local basis, which is crucial in assessing the performance of targeted olfactory drug delivery. OBJECTIVES: To visually and quantitatively compare drug depositions in the nose and olfactory region with normal and bidirectional breathing patterns with vibrating mesh and jet nebulizers...
April 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27792477/suppression-of-tobacco-carcinogen-induced-lung-tumorigenesis-by-aerosol-delivered-glycerol-propoxylate-triacrylate-spermine-copolymer-short-hairpin-rab25-rna-complexes-in-female-a-j-mice
#17
Nomundelger Gankhuyag, Kyeong Nam Yu, Orkhonselenge Davaadamdin, Somin Lee, Won Young Cho, Changhoon Park, Hu-Lin Jiang, Bijay Singh, Chan-Hee Chae, Myung-Haing Cho, Chong-Su Cho
BACKGROUND: Rab25, a member of Rab family of small guanosine triphosphatase, is associated with progression of various types of human cancers, including lung cancer, the leading cause of cancer-associated deaths around the globe. METHODS: In this study, we report the gene therapeutic effect of short hairpin Rab25 RNA (shRab25) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice. Initially, mice (6 weeks old) were injected with single dose of NNK (2 mg/0...
April 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27754730/a-novel-in-line-delivery-system-to-administer-dry-powder-mannitol-to-mechanically-ventilated-patients
#18
Benny Feng, Patricia Tang, Sharon Shui Yee Leung, Jayesh Dhanani, Hak-Kim Chan
BACKGROUND: Mechanically ventilated patients commonly suffer from ventilator-associated pneumonia, hypoxemia, and other lower respiratory tract infection as a result of pathogen colonization and poor sputum clearance. Consequently, there is a high rate of morbidity and mortality in these patients. Dry powder mannitol increases sputum clearance, and therefore, we developed a system to administer it to mechanically ventilated patients without disconnection from the ventilator. METHODS: The inspiratory line from a ventilator was split by using a three-way valve into two parallel lines where one contains a humidifier for normal breathing cycle and the other line contains a dry powder inhaler (Osmohaler™)...
April 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27740878/predicting-exposure-after-oral-inhalation-of-the-selective-glucocorticoid-receptor-modulator-azd5423-based-on-dose-deposition-pattern-and-mechanistic-modeling-of-pulmonary-disposition
#19
Per Bäckman, Ulrika Tehler, Bo Olsson
BACKGROUND: Exposure following oral inhalation depends on the deposition pattern of the inhaled aerosol, the extent and rate of oral and pulmonary absorption, as well as systemic distribution and clearance. For lipophilic inhaled compounds with low water solubility and high permeability, the extent and rate of pulmonary absorption can be assumed dependent on deposition pattern as well as dissolution rate. MATERIALS AND METHODS: A mechanistic model of airway deposition, mucociliary clearance, dissolution, absorption, and dissipation was applied to simulate systemic exposure of the novel selective glucocorticoid receptor modulator, AZD5423, when dosed to healthy volunteers using two different nebulizers and two different dry powder inhalers in combination with two different primary particle size distributions...
April 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27563742/the-advantages-of-adding-hyaluronic-acid-or-mannitol-to-hypertonic-saline-inhalation-treatment-in-cystic-fibrosis
#20
Clizia Cazzarolli, Chiara Tartali, Ugo Pradal
No abstract text is available yet for this article.
April 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
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