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International Journal of Rheumatic Diseases

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https://www.readbyqxmd.com/read/30207074/5-ht-2-and-5-ht-2b-antagonists-attenuate-pro-fibrotic-phenotype-in-human-adult-dermal-fibroblasts-by-blocking-tgf-%C3%AE-1-induced-non-canonical-signaling-pathways-including-stat3
#1
Saurabh Chaturvedi, Durga Prasanna Misra, Narayan Prasad, Kailash Rastogi, Harshit Singh, Mohit Kumar Rai, Vikas Agarwal
BACKGROUND: Release of 5-hydroxytryptamine (5-HT; serotonin) from activated platelets following microvascular injury leads to tissue fibrosis. 5-HT strongly induces extracellular matrix synthesis in dermal fibroblasts in a transforming growth factor beta 1 (TGF-β1)-dependent manner. AIM: To evaluate anti-fibrotic properties of inhibitors of 5-HT2 and 5-HT2B (terguride, SB204741) respectively in human adult dermal fibroblasts (HADF) derived from a patient with scleroderma...
September 12, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30187695/aerobic-exercise-for-axial-spondyloarthritis-its-effects-on-disease-activity-and-function-as-compared-to-standard-physiotherapy-a-systematic-review-and-meta-analysis
#2
Frank Verhoeven, Xavier Guillot, Clément Prati, Fabienne Mougin, Nicolas Tordi, Céline Demougeot, Daniel Wendling
AIM: To evaluate the impact of an aerobic fitness program on disease activity, defined by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and on C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and the Bath Ankylosing Spondylitis Functional Index (BASFI) in case of axial spondyloarthritis. METHODS: A systematic review of the literature, following the Prisma recommendations, was performed by two reviewers on the PubMed and Embase databases...
September 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30187688/a-multicentre-observational-study-comparing-patient-reported-outcomes-to-assess-reliability-of-swollen-and-tender-joint-assessments-and-response-to-certolizumab-treatment-as-compared-to-clinician-assessments-in-rheumatoid-arthritis
#3
Charles A Inderjeeth, Adrisha J Inderjeeth, Warren D Raymond
AIMS: The use of swollen (SJC) and tender joint counts (TJC) for rheumatoid arthritis (RA) disease activity and treatment effectiveness is well established. Patient-reported outcomes (PRO) are important. However, it is unknown if patient scoring is as reliable as that of trained professionals. METHODS: PRO including SJC and TJC were assessed at baseline, 6 and 12 weeks by patients and clinicians. Data were collected using ePRO (electronic) and pPRO (paper). The Least Squares Method (LSM), Pearson correlation (Rs) and weighted Kappa scores were used to assess inter-rater reliability and agreement of responses between the patient, nurse and physician for changes in TJC and SJC from 0 to 12 weeks of treatment...
September 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30187686/radiologic-features-in-symptomatic-asymptomatic-heels-of-patients-with-ankylosing-spondylitis
#4
Tae-Hwan Kim, Jin Kyu Lee, Hyo-Kyung Sung, Bo-Hyun Kim, Young-Sik Song, Il-Hoon Sung
AIM: Most heel pain occurs at the posterior or plantar aspect, where main entheses of the heel are located. However, simple radiographs as basic work-up tools, their features based on their association with local symptoms in the heel in ankylosing spondylitis (AS) patients, have rarely been described. METHOD: Forty patients with AS and unilateral heel pain were enrolled to evaluate radiographic differences between symptomatic and asymptomatic heels. The two groups were assessed according to symptom location: posterior (group PS) or plantar (group PL)...
September 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30187679/is-sonoelastography-a-helpful-method-of-evaluation-to-diagnose-sj%C3%A3-gren-s-syndrome
#5
López-Jornet Pia, Berna Mestre Juan, Pina Frank, Aniorte Alegria Angela, Gálvez Jose, Berna Serna Juan de Dios
OBJECTIVE: A new sonoelastography technique - virtual touch tissue quantification of acoustic radiation force impulses (ARFI) - offers a promising method for measuring tissue rigidity. The aim of this study was to assess the usefulness of ARFI for diagnosing Sjögren's syndrome (SS). METHODS: This transversal prospective study included 41 patients with SS according to American-European Consensus Group (AECG) criteria, and a control group without symptoms. All subjects underwent ARFI high-resolution ultrasound assessment of the parotid glands (PG) and submandibular glands (SMG)...
September 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30187668/arthritis-in-sarcoidosis-a-multicentric-study-from-india
#6
Vikas Agarwal, Vinita Agrawal, Amita Aggarwal, Parshant Aggarwal, Abhra C Chowdhury, Parasar Ghosh, Avinash Jain, Able Lawrence, Durga P Misra, Ramnath Misra, Madhusmita M Mohapatra, Alok Nath, Vir S Negi, Sapan Pandya, Vishnu V Reddy, Shiva Prasad, Aman Sharma, Vineeta Shobha, Yogesh P Singh, Saumya R Tripathy, Anupam Wakhlu
INTRODUCTION: Ten to 15% of patients with sarcoidosis have associated arthritis. Chronic arthritis is fairly uncommon. There is a paucity of data on articular manifestations of the disease from India. METHODS: Case records of adult patients with sarcoidosis presenting to 11 rheumatology centers from 2005 to 2017 were retrospectively reviewed. Joint involvement was assessed clinically, classified as acute or chronic depending on duration of symptoms less or greater than 6 months, respectively...
September 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30187667/long-term-patient-reported-outcomes-of-elbow-wrist-and-hand-surgery-for-rheumatoid-arthritis
#7
Chisa Okura, Hajime Ishikawa, Asami Abe, Yukio Yonemoto, Koichi Okamura, Takahito Suto, Tomo Oyakawa, Yusuke Miyagawa, Hiroshi Otani, Satoshi Ito, Daisuke Kobayashi, Kiyoshi Nakazono, Akira Murasawa, Kenji Takagishi, Hirotaka Chikuda
AIM: A retrospective questionnaire survey was conducted to investigate the long-term outcomes of elbow, wrist and hand surgery for rheumatoid arthritis (RA). METHODS: One hundred and thirteen RA patients underwent primary elective elbow, wrist or hand surgery at our hospital between January 2002 and December 2003. To evaluate the outcomes at 10 years after surgery, the patient-reported outcomes were assessed using an original questionnaire that inquired about the site of treatment; the modified Stanford Health Assessment Questionnaire (mHAQ) was also used...
September 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30187662/matrix-metalloprotease-3-is-associated-with-sarcopenia-in-rheumatoid-arthritis-results-from-the-chikara-study
#8
Masahiro Tada, Yutaro Yamada, Koji Mandai, Noriaki Hidaka
AIM: Patients with rheumatoid arthritis (RA) show lower muscle mass and a higher prevalence of sarcopenia than healthy individuals. Correlations between sarcopenia and disease activity, physical function, laboratory data and body composition at baseline were investigated in a prospective, observational study (CHIKARA study) of RA patients. METHODS: Body composition was measured using a bioelectrical impedance analyzer. Parameters were compared between sarcopenia and non-sarcopenia groups, and correlations between sarcopenia and Disease Activity Score of 28 joints - erythrocyte sedimentation rate (DAS28-ESR), modified health assessment questionnaire, treatment, and laboratory data, including matrix metalloproteinase 3 (MMP3), were investigated...
September 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30178511/distribution-of-rheumatological-diseases-in-rural-and-urban-areas-an-adapted-copcord-stage-i-phase-iii-survey-of-lucknow-district-in-north-india
#9
Puneet Kumar, Ragini Alok, Siddharth K Das, Ragini Srivastava, Girdhar G Agarwal
OBJECTIVES: To study the distribution of various rheumatological diseases in rural and urban areas of Lucknow, India. METHOD: A study using adapted a Community Oriented Program for the Control of Rheumatic Diseases scheme was carried out in a cluster of rural (n = 5118) and urban (n = 5053) communities through a door-to-door survey. Trained community volunteers completed the questionnaires. Patients with musculoskeletal pain (MSK pain) were clinically evaluated by a physician...
September 4, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30175554/influence-of-pain-score-measured-by-a-visual-analog-scale-ps-vas-on-the-health-assessment-questionnaire-disability-index-and-28-joint-disease-activity-index-with-c-reactive-protein-in-rheumatoid-arthritis-patients
#10
Ichiro Yoshii, Tatsumi Chijiwa, Naoya Sawada
BACKGROUND: Pain is a serious burden for rheumatoid arthritis (RA) patients. However, the effect on Health Assessment Questionnaire Disability Index (HAQ-DI) and 28-joint Disease Activity Score (DAS28) has not been presented. The aim of this study is to evaluate them in a case series. METHODS: Three hundred and eighty-two RA patients who were treated for more than 5 years were studied. The parameters assessed included average value of the DAS28 with C-reactive protein (DAS28-CRP), the HAQ-DI score, the Sharp/van der Heijde Score (SvdHS), age, and the pain score measured by a visual analog scale (PS-VAS)...
September 2, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168281/biologics-and-risk-of-tuberculosis-in-autoimmune-rheumatic-diseases-a-real-world-clinical-experience-from-india
#11
Vineeta Shobha, S Chandrashekara, Vijay Rao, Anu Desai, Ramesh Jois, Balebail G Dharmanand, Sharath Kumar, Pradeep Kumar, Chethana Dharmapalaiah, Kurugodu Mathada Mahendranath, Shiva Prasad, Manisha Ashwin Daware, Yogesh Singh, Uma Karjigi, S Nagaraj, K R Anupama
AIM: Tuberculosis (TB) is one of the major adverse events of concern associated with the use of biologics for managing autoimmune inflammatory rheumatic diseases (AIRDs). The study presents the data on incidence of TB in relation to biologic used, screening test and TB prophylaxis in a real-world setting. METHODS: The cross-sectional, observational, retrospective study was conducted across 12 centres in Karnataka, India. The study included patients receiving biologics therapy for AIRDs, established based on the respective diagnostic criteria...
August 30, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168280/autoantibody-profile-in-children-with-kawasaki-disease-on-long-term-follow-up-a-prospective-study-from-north-india
#12
Aseem Basha, Amit Rawat, Ankur K Jindal, Anju Gupta, Shashi Anand, Ravinder Garg, Ranjana W Minz, Surjit Singh
AIM: To study the profile of autoantibodies on long-term follow-up of children with Kawasaki disease (KD). PATIENTS AND METHODS: In this single-center observational cohort study, 50 children who had been diagnosed and treated for KD with a minimum follow-up period of 3 years were enrolled. The organ-specific autoantibodies that were assessed in the study included anti-thyroid microsomal antibody (TMA), anti-parietal cell antibody (PCA) and anti-liver kidney microsomal (LKM) antibody...
August 30, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168277/carotid-ultrasound-findings-in-rheumatoid-arthritis-and-control-subjects-a-case-control-study
#13
Martin I Wah-Suarez, Dionicio A Galarza-Delgado, Jose R Azpiri-Lopez, Iris J Colunga-Pedraza, Estefania E Abundis-Marquez, Jose A Davila-Jimenez, Cinthia Y Guillen-Gutierrez, Guillermo Elizondo-Riojas
Rheumatoid arthritis (RA) is a chronic, inflammatory disease closely linked with atherosclerosis. Recommended cardiovascular disease (CVD) integral evaluation includes screening for asymptomatic atherosclerosis plaques with carotid ultrasound (US). The aim of this study is to evaluate the carotid US characteristics, including carotid intima media thickness (cIMT) and carotid plaque (CP), and compare RA-patients and controls in a Mexican-mestizo population. METHOD: Prospective cross-sectional, observational study comparing RA-patients and matched controls without RA...
August 30, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168276/evaluation-of-joint-cartilage-thickness-in-healthy-children-by-ultrasound-an-experience-from-a-developing-nation
#14
Moumita Samanta, Sonali Mitra, Partha P Samui, Rakesh K Mondal, Avijit Hazra, Tapas K Sabui
OBJECTIVES: Musculoskeletal ultrasound (MSUS) has a crucial role in clinical assessment and monitoring of patients with rheumatologic diseases. Early detection of joint cartilage destruction is difficult. MSUS is a cheap, noninvasive, nonhazardous bedside tool that can be used for detection of cartilage damage. We aimed to generate normative data of joint cartilage thickness of children in our population using this tool. METHODS: Healthy children, aged between 2 and 12 years, not suffering from any joint disorders and not on any chronic medication were recruited...
August 30, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168274/influence-of-methotrexate-on-gastrointestinal-symptoms-in-patients-with-rheumatoid-arthritis
#15
Shuji Asai, Kaoru Nagai, Nobunori Takahashi, Tatsuo Watanabe, Takuya Matsumoto, Nobuyuki Asai, Yasumori Sobue, Naoki Ishiguro, Toshihisa Kojima
AIM: This study aimed to determine the influence of methotrexate (MTX) on gastrointestinal (GI) symptoms in patients with rheumatoid arthritis (RA). METHODS: This cross-sectional study examined 529 consecutive patients with RA receiving oral MTX in our department between April 1 and September 30, 2017. GI symptoms were evaluated by the Gastrointestinal Symptom Rating Scale (GSRS); a score of ≥2 was considered "symptomatic." Prevalence of GI symptoms was compared between patients receiving ≤8 mg/wk (low-dose) vs >8 mg/wk (high-dose) of MTX...
August 30, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168273/foxp3-rs3761548-polymorphism-is-associated-with-knee-osteoarthritis-in-a-turkish-population
#16
Nilgun Cekin, Ergun Pinarbasi, Aslıhan Esra Bildirici, Gonca Donmez, Zekeriya Oztemur, Okay Bulut, Serdal Arslan
AIM: Functional polymorphisms located in FOXP3 intron 1 was recently found to be associated with rheumatoid arthritis (RA). Although RA is an autoimmune disease, there is supporting evidence that activated maladaptive responses including pro-inflammatory pathways play roles in osteoarthritis (OA), similar to RA. The aim of this study was to explore the relationship between rs2232365 (-924A/G) and rs3761548 (-3279A/C) polymorphisms as well as possible changes in the 600 bp promoter region of FOXP3 and knee OA...
August 30, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168272/efficacy-of-abatacept-tapering-therapy-for-sustained-remission-in-patients-with-rheumatoid-arthritis-prospective-single-center-study
#17
Shuzo Yoshida, Takuya Kotani, Yuko Kimura, Yoko Matsumura, Ayaka Yoshikawa, Nao Tokai, Takuro Ozaki, Koji Nagai, Toru Takeuchi, Shigeki Makino, Shigeki Arawaka
AIM: To investigate whether remission can be sustained for rheumatoid arthritis (RA) patients after tapering abatacept (ABT). METHOD: All patients were naïve to biological disease-modifying anti-rheumatic drugs (bDMARDs) and in low or moderate Disease Activity Score of 28 joints with C-reactive protein (DAS)28-CRP). ABT was administrated intravenously (IV) or subcutaneously (SC) for 36 weeks to patients with RA, who had not previously received bDMARDs. As the ABT tapering protocol, ABT was administrated SC at 125 mg every 2 weeks for 12 weeks in patients with remission...
August 30, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168270/early-onset-neutropenia-and-thrombocytopenia-following-rituximab-in-lupus-nephritis
#18
Sanket Shah, Chengappa G Kavadichanda, Pooja Belani, Rajesh N Ganesh, Vir Singh Negi
Biologics have emerged as an important modality of treatment in rheumatic diseases and have allowed the rheumatologist to explore varied therapeutic uses of these drugs. Rituximab, a monoclonal antibody against CD20 receptor is an important member of the biologic armamentarium for the treatment of various refractory autoimmune inflammatory rheumatic diseases. The drug is now widely used in systemic lupus erythematosus for several complications which are refractory to conventional therapy. Although relatively safe, the post-marketing surveillance of rituximab has revealed a few rare but important adverse reactions...
August 30, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168267/hospitalizations-due-to-systemic-connective-tissue-diseases-secular-trends-and-regional-disparities-in-sweden-1998-2016
#19
Aliasghar A Kiadaliri, Aladdin J Mohammad, Martin Englund
AIM: To investigate secular trends and regional disparities in hospitalizations due to systemic connective tissue diseases (SCTD) in Sweden from 1998 to 2016. METHOD: We identified all hospital admissions with a principal diagnosis of SCTD (ICD-10 codes: M30-M36) from the Swedish National Patient Register. Joinpoint regression was used to assess secular trends in age-standardized hospitalization rates (ASHR) and proportions of SCTD from all and musculoskeletal disorders hospitalizations...
August 30, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30168265/retention-rates-of-adalimumab-etanercept-and-infliximab-as-first-or-second-line-biotherapies-for-spondyloarthritis-patients-in-daily-practice-in-auvergne-france
#20
Martin Soubrier, Bruno Pereira, Angelique Fan, Thomas Frayssac, Marion Couderc, Sandrine Malochet-Guinamand, Sylvain Mathieu, Zuzana Tatar, Anne Tournadre, Jean-Jacques Dubost
OBJECTIVE: To compare, in real-life settings, the retention rates of initial anti-tumor-necrosis factor (TNF) treatments (etanercept [ETN], adalimumab [ADA] and infliximab [IFX]) used as first-line biotherapy for axial spondyloarthritis (axSpA), and evaluate treatment switches to another anti-TNF inhibitor in the event of treatment failure. METHODS: We analyzed the medical records of all SpA patients (Assessment in Ankylosing Spondylitis International Working Group axial criteria) treated with ETN, IFX or ADA between 2001 and February 2015...
August 30, 2018: International Journal of Rheumatic Diseases
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