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International Journal of Rheumatic Diseases

York Kiat Tan, Li-Ching Chew, John C Allen, Weng Kit Lye, Lei Lei Htay, Ali Hassan, Philip G Conaghan, Julian Thumboo
OBJECTIVE: To determine the utility of ultrasonography in guiding modification of disease-modifying anti-rheumatic drug (DMARD) and steroid therapy for inflammatory arthritis (IA) in routine clinical practice. METHODS: In this retrospective study, we analyzed DMARD and steroid use in IA patients referred to a rheumatologist-led ultrasound clinic. Power Doppler (PD) vascularity and greyscale (GS) synovial hypertrophy joint findings were categorized as positive/negative for each patient...
August 19, 2016: International Journal of Rheumatic Diseases
Shyamashis Das, Alakendu Ghosh, Parasar Ghosh, Debasish Lahiri, Pradyot Sinhamahapatra, Kaushik Basu
AIM: This study aimed to assess the sensitivity and specificity of ultrasonographic features of gout in intercritical and chronic stages and compared ultrasonographic features of gout between patients with persistent high serum uric acid (SUA) and patients with low SUA. METHODS: Adult patients with gout confirmed by demonstration of monosodium urate crystals were recruited, if they were in intercritical or chronic stage clinically. Ultrasonographic examination of the first metatarsophalangeal joints (MTPJs) and the knee joints of both sides were done by a blinded rheumatologist trained in musculoskeletal ultrasound...
August 16, 2016: International Journal of Rheumatic Diseases
Natsuki Shima, Takao Nagashima, Masahiro Iwamoto, Seiji Minota
No abstract text is available yet for this article.
August 12, 2016: International Journal of Rheumatic Diseases
Alexander J Rodríguez, David Scott, Peter Ebeling, Bo Abrahamsen
No abstract text is available yet for this article.
August 12, 2016: International Journal of Rheumatic Diseases
Sukesh Edavalath, Abhra C Chowdhury, Sanat Phatak, Durga P Misra, Ritu Verma, Able Lawrence
Multiple myeloma can rarely mimic seronegative rheumatoid arthritis (RA). We report a 55-year-old woman who presented with longstanding deforming polyarthritis with extensive subcutaneous nodules, tenosynovitis, anti-cyclic citrullinated peptide positivity and mononeuritis multiplex. Even though the clinical picture was consistent with seropositive RA, the absence of bone erosion or joint space narrowing on hand and knee radiographs led us to question the diagnosis of RA. Further investigation revealed a diagnosis of multiple myeloma with cutaneous amyloid deposits, based on serum immunofixation, bone marrow aspiration and biopsy of a subcutaneous nodule...
August 12, 2016: International Journal of Rheumatic Diseases
Sinem Sarı, Osman N Aydın, Yasemin Turan, Pınar Özlülerden, Ufuk Efe, İmran Kurt Ömürlü
OBJECTIVES: To compare the efficacy of intra-articular injection and radiofrequency (RF) neurotomy of genicular nerves in patients with chronic knee osteoarthritis (OA) pain. METHODS: Seventy-three patients with knee OA were included in the study. Patients were randomly assigned to Group IA (intra-articular 2.5 mL of bupivacaine, 2.5 mg of morphine and 1 mL of betamethasone, 6 mL of fluid injection) or Group RF (RF neurotomy of the genicular nerves). The outcome measures included a pain scale (visual analog scale, VAS) and Western Ontario and McMaster Universities (WOMAC) Index of Osteoarthritis...
August 12, 2016: International Journal of Rheumatic Diseases
Young Sun Suh, Yun-Hong Cheon, Ji Eun Kim, Ji-Min Kim, Sang-Hyon Kim, Won-Seok Lee, Wan-Hee Yoo, Sang-Il Lee, Hyun-Ok Kim
AIM: To investigate whether plain radiography is useful for assessing the changes in gouty tophi size following hypouricemic therapy. METHODS: Gout was diagnosed according to the American College of Rheumatology criteria. Before and after hypouricemic treatment, serum uric acid level was measured, and plain radiography was performed to measure gouty tophi size. The tophi were graded by measuring the maximum vertical and horizontal diameters, and they were scored by adding up the scores of the grades...
August 12, 2016: International Journal of Rheumatic Diseases
Min Zhao, Yishuo Li, Weiguo Xiao
AIM: Inadequate apoptosis of fibroblast-like synoviocytes (FLS) plays a crucial role in the immunopathogenesis of rheumatoid arthritis (RA). Interleukin-22 (IL-22) is a novel member of the cytokine network that has been found to be involved in the immunological process underlying RA. In this study, we investigated the effect of IL-22 on the survival of RA-FLS from RA patients and examined the possible mechanism to determine new therapeutic strategies for RA. METHODS: FLS obtained from patients with RA were cultured in vitro and treated with sodium nitroprussiate (SNP) to induce apoptosis in the presence or absence of IL-22...
August 4, 2016: International Journal of Rheumatic Diseases
Fang Zhang, Yu Yang, Tao Huang, Yiye Zhang, Li Zhao, Shuchuen Li
BACKGROUND: The use of both generic and disease-specific instruments in assessing quality of life (QoL) in subjects may pose a barrier in a busy clinical setting with heavy case load. Our current study attempted to evaluate the responsiveness of generic scales, EQ-5D and SF-6D, as compared with a disease-specific instrument, AIM2-SF, in patients with osteoarthritis, to judge which of the two generic instruments would be more suitable to be used alone in the clinical setting. METHODS: Correlation tests with Pearson correlation coefficient were carried out between EQ-5D and SF-6D scales, and AIMS2-SF scale for both 100 first-diagnosed osteoarthritis patients and 22 patients with two follow-up interviews...
July 27, 2016: International Journal of Rheumatic Diseases
Gülcan Gürer, Gulnur Tasci Bozbas, Tiraje Tuncer, Ayse Iyiyapici Unubol, Ulku Gurbuz Ucar, Ozge Illeez Memetoglu
AIM: Osteoarthritis (OA) of the knee is one of the major causes of joint dysfunction and physically disabling conditions in the older population. The risk factors for the development of knee OA are very diverse. We aimed to determine the frequency of joint hypermobility in patients with knee OA. METHODS: Five hundred and three patients (402 female and 101 male) with bilateral knee OA were enrolled in five different clinics from three regions of Turkey. In this study, joint hypermobility was evaluated in the participants by using the Beighton scoring system and a Beighton score of at least 4 was considered as joint hypermobility...
July 27, 2016: International Journal of Rheumatic Diseases
Gabriel S Breuer, Naama Bogot, Gideon Nesher
AIM: The aim of this study is to evaluate the diagnostic yield of dual-energy computed tomography (DECT) in detection of uric acid accumulation in joints or periarticular structures in patients suspected of having gout, in their intercritical period. METHODS: Patients with a history of recurrent, short-lived mono- or oligo-arthralgia or arthritis, referred to the rheumatology clinic for diagnosis of their condition, were included in this retrospective evaluation...
July 26, 2016: International Journal of Rheumatic Diseases
Mustafa Al Izzi, Ashraf Reda
No abstract text is available yet for this article.
July 26, 2016: International Journal of Rheumatic Diseases
Elizabeth Chew, Konstadina Griva, Peter P Cheung
AIM: To evaluate coping strategies of Asian RA patients and their associations with health-related quality of life (HRQoL). METHODS: A cross-sectional sample of patients with established RA was evaluated using measures of coping (Coping in Rheumatoid Arthritis Questionnaire [C-RAQ]; appraisal of coping effectiveness and helplessness), HRQoL (Mental and Physical Components [MCS/PCS] of the Short Form 12v2; Rheumatoid Arthritis Impact of Disease score [RAID]) and clinical/laboratory assessments...
July 26, 2016: International Journal of Rheumatic Diseases
Ken-Ichi Ueno, Yasuhiro Shimojima, Dai Kishida, Yoshiki Sekijima, Shu-Ichi Ikeda
AIM: The purpose of this study was to investigate the therapeutic advantage of administering tacrolimus (TAC) in patients with polymyositis (PM) and dermatomyositis (DM). METHODS: We retrospectively analyzed the clinical outcomes after initiating treatment in 66 patients with PM/DM (28 PM and 38 DM). After initiating treatment, the prognosis was compared between patients who received TAC in combination with prednisolone (PSL) (the concomitant TAC group), and patients who were treated with PSL alone...
July 26, 2016: International Journal of Rheumatic Diseases
Sagrario Pérez de la Cruz, Johan Lambeck
BACKGROUND: Fibromyalgia syndrome (FMS) is a rheumatic disorder that presents with physical, psychological and social symptoms. OBJECTIVE: The aim of this study was to assess the effects of a program of water-based Ai Chi on the health-related quality of life of subjects with FMS. METHODS: An experimental pilot study was performed with a sample of 20 female subjects diagnosed with FM and recruited from two different settings. Assessments were performed using the a visual analog scale and the Short Form-36 physical and mental health summary scores...
July 26, 2016: International Journal of Rheumatic Diseases
Rezan Topaloglu, Ezgi Deniz Batu, Çigdem Yıldız, Emine Korkmaz, Seza Özen, Nesrin Beşbaş, Fatih Özaltın
AIM: Familial Mediterranean fever (FMF) results from MEFV gene mutations. E148Q is a variant of unknown significance in MEFV. We aimed to define characteristics of FMF patients homozygous for E148Q, check for other MEFV variants in a subgroup, and compare the characteristics with FMF patients carrying other mutations. METHODS: Thirty FMF patients homozygous for E148Q were reviewed. MEFV variant analysis was performed with strip assay. All MEFV exons were screened by direct DNA sequencing in 14 randomly selected E148Q/E148Q patients...
July 26, 2016: International Journal of Rheumatic Diseases
Sarvajeet Pal, Sarath Chandra Mouli Veeravalli, Siddharth Kumar Das, Vineeta Shobha, Ramakrishna Rao Uppuluri, B G Dharmanand, Milind Nadkar, Elizabeth Hsia, Kaiyin Fei, Ruji Yao, Ahmed Khalifa
AIM: To conduct a subgroup analysis of GO-MORE trial Part 1, comparing efficacy and safety of add-on subcutaneous golimumab therapy in rheumatoid arthritis (RA) patients enrolled from and outside India. METHODS: GO-MORE was an open-label, multicenter, prospective trial of add-on golimumab in biologic-naïve RA patients, having active disease despite being on conventional DMARD regimen(s). Part 1 of the study was chosen as the focus of this subgroup analysis because a substantial number of Indian patients (106) were enrolled compared to no Indian patients in Part 2...
July 26, 2016: International Journal of Rheumatic Diseases
Sanat Phatak, Amita Aggarwal, Vikas Agarwal, Able Lawrence, Ramnath Misra
AIM: Anti-neutrophil cytoplasmic antibodies (ANCA) are associated with small vessel vasculitis now termed 'ANCA associated vasculitis' (AAV). ANCAs are reported in diverse diseases where they have no clinical utility. We carried out an audit in a clinical immunology laboratory and assessed if use of ordering practices could have improved utility of ANCA. METHODS: All samples received for ANCA testing during 2014 were tested by indirect immunofluorescence (IIF) and automated enzyme-linked immunosorbent assay (ELISA)...
July 26, 2016: International Journal of Rheumatic Diseases
Jun-Hyun Kim, Kyung-Ann Lee, Min-Young Jung, Ah-Ran Kim, Jeong-Min Yoon, Hyoung-Joon Shim, Sang-Heon Lee, Ho-Youn Kim, Hae-Rim Kim
Pulmonary thromboembolism (PTE) is rarely reported in Behçet's disease (BD) due to its distinctive thrombus-forming mechanism. In BD, the inflammation on vessel walls causes venous thrombosis. The thrombi are considered to be tethered to the inflamed walls making embolization less frequent. Thus, immunosuppressive agents are the mainstay of treatment. However, the necessity of anticoagulation therapy is controversial because of its uncertain efficacy of resolving thrombi and the possibility of fatal side effects of hemorrhage...
July 26, 2016: International Journal of Rheumatic Diseases
Suparaporn Wangkaew, Chate Sivasomboon, Wit Leungwatthananon, Nuntana Kasitanon, Worawit Louthrenoo
AIM: Data regarding the clinical and radiographic hand involvement in Asian patients with systemic sclerosis (SSc) are limited. Thus, we determined the prevalence of clinical and radiographic hand involvement in Thai SSc patients, comparing diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc). We also determined the factors associated with arthritis, contracture of fingers and digital ulcers. METHOD: SSc patients seen at the Rheumatology Clinic, Chiang Mai University, Thailand, from December 2012 to June 2013 were consecutively invited to enroll in the study...
July 26, 2016: International Journal of Rheumatic Diseases
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