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International Journal of Rheumatic Diseases

Eliza K Pontifex, Kokum Dissanayake, David Bursill, Tiffany Gill
AIM: Discrepancies exist between international treatment guidelines and current Australian Pharmaceutical Benefits Scheme (PBS) criteria for funding biologic disease-modifying antirheumatic drug (bDMARD) prescribing in psoriatic arthritis (PsA). We aimed to determine the prevalence of minimal disease activity (MDA) achievement and differences in inflammatory marker levels between PsA patients who have and have not met the Australian PBS criteria for bDMARDs. METHOD: Consecutive participants diagnosed with PsA were assessed for MDA components and serum inflammatory markers...
November 18, 2018: International Journal of Rheumatic Diseases
Li-Ching Chew, Xiaohui Xin, Hui Yang, Julian Thumboo
OBJECTIVES: To study clinical and patient reported outcomes for the Virtual Monitoring Clinic (VMC), a remote nurse-led telemonitoring service for monitoring Rheumatoid Arthritis (RA) patients treated with disease-modifying antirheumatic drugs (DMARDs). METHODS: Patients with stable RA enrolled in the VMC were followed up prospectively. The primary outcomes evaluated at 1-year follow-up were: Disease Activity Score-28 (DAS28), Routine Assessment of Patient Index Data 3 (RAPID3), and patient satisfaction assessed using an 11-point Likert scale...
November 18, 2018: International Journal of Rheumatic Diseases
Marina Rodríguez, Montse Guardiola, Iris Oliva, Joan Carles Vallvé, Raimon Ferré, Lluís Masana, Sandra Parra, Josep Ribalta, Antoni Castro
AIMS: Patients with systemic lupus erythematosus (SLE) suffer from accelerated atherosclerosis. Their most common cause of death is a cardiovascular disease (CVD), in spite of the presence of moderate lipid alterations and normal cardiovascular risk scores. However, cholesterol still accumulates in the arteries of SLE patients, so we aim to identify additional factors that may help explain the residual risk that exists in these patients. We focus on investigating whether the net charge contributes significantly to both the development and the progression of atherosclerosis in patients with SLE...
November 18, 2018: International Journal of Rheumatic Diseases
Lin Li, Yafei Cui, Shengnan Chen, Qian Zhao, Ting Fu, Juan Ji, Liren Li, Zhifeng Gu
OBJECTIVE: The purpose of this meta-analysis was to systematically review the literature to evaluate the impact of systemic sclerosis (SSc) on the health-related quality of life (HRQoL) assessed by the Medical Outcomes Short-Form-36 questionnaire (SF-36). METHODS: A systematic literature search was performed on PubMed, Web of Science and Embase until April 2017 to obtain eligible studies. Random effect model was performed to summarize the scores of each domain. Scores from the SF-36 questionnaire were used as the outcome measurements, and mean differences with 95% confidence intervals were calculated...
November 14, 2018: International Journal of Rheumatic Diseases
Masako Tsukamoto, Katsuya Suzuki, Tsutomu Takeuchi
AIM: Anti-centromere antibody (ACA) is often detected in patients with autoimmune diseases, including limited cutaneous systemic sclerosis (SSc), Sjögren's syndrome (SS), and primary biliary cholangitis (PBC). The association between autoimmune disease and ACA positivity remains unclear. We sought to clarify the clinical features of ACA-positive patients and their association with autoantibodies. METHOD: A total of 309 cases of a discrete-speckled pattern anti-nuclear antibody (ANA) test and/or positive ACA who visited our department were retrospectively enrolled...
November 14, 2018: International Journal of Rheumatic Diseases
Young Ho Lee, Gwan Gyu Song
AIM: We aimed to evaluate the relationship between mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and Behçet's disease (BD). METHODS: We searched Medline, Embase, and Cochrane databases, and performed a meta-analysis to compare MPV, NLR, and PLR between patients with BD and healthy controls, and to evaluate these parameters in BD according to disease activity and thrombosis. RESULTS: In total, 14 studies were included...
November 11, 2018: International Journal of Rheumatic Diseases
Koichi Murata, Hiromu Ito, Motomu Hashimoto, Kohei Nishitani, Kosaku Murakami, Masao Tanaka, Wataru Yamamoto, Tsuneyo Mimori, Shuichi Matsuda
AIM: Age at disease onset has been implicated as an indicator of disease activity and severity in rheumatoid arthritis (RA). This study aimed to investigate how old age at disease onset affects patient treatment and prognosis in early RA. METHODS: Data from the Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort was analyzed. From 2011 to 2015, a total of 2182 patients with RA were enrolled in the cohort; 239 patients were newly diagnosed with RA and were followed up for 2 years...
November 11, 2018: International Journal of Rheumatic Diseases
Sungsin Jo, Jinil Han, Young L Lee, Subin Yoon, Jaehyun Lee, Sung E Wang, Tae-Hwan Kim
AIM: Ankylosing spondylitis (AS) is characterized by excessive spinal ankylosis and bone formation. Alkaline phosphatase (ALP) activity is reported to be high in AS, but little is known about the molecular relationship between ALP and AS. The aims of this study were to investigate the relevance of ALP to AS and the role of ALP in the regulation of osteoblast differentiation in AS. METHODS: High-throughput data with accession numbers GSE73754 and GSE41038 were downloaded from the Gene Expression Omnibus...
November 11, 2018: International Journal of Rheumatic Diseases
Jing Luo, Shihao Xu, Yinqiu Lv, Xinshi Huang, Huxiang Zhang, Xiaochun Zhu, Xiaobing Wang
OBJECTIVE: To investigate distinct features of renal involvement in patients with primary Sjögren's syndrome (pSS) and to identify potential factors associated with renal involvement. METHODS: Four hundred and thrity-four pSS patients from the Rheumatology Department of the First Affiliated Hospital of Wenzhou Medical University from 2013 to 2017 were included in a cross-sectional study. Patients with renal involvement were compared with their age- and gender-matched controls (pSS without renal involvement)...
November 8, 2018: International Journal of Rheumatic Diseases
Yu Heng Kwan, Warren Fong, Ying Ying Leung, Victoria Ie Ching Tan, Angela Frances Yap, Jie Kie Phang, Nai Lee Lui, Sungwon Yoon, Rahul Malhotra, Julian Thumboo, Truls Østbye
AIMS: To identify quality of life (QoL) domains and subdomains relevant to patients with different spondyloarthritis (SpA) subtypes in Singapore, and to assess how identified QoL domains and subdomains map onto currently used patient-reported outcome measures (PROMs). METHODS: Nine focus group discussions (FGDs), including two previously conducted FGDs from the Updating the Psoriatic Arthritis Core Domain Set Study, were conducted with patients with SpA in Singapore...
November 8, 2018: International Journal of Rheumatic Diseases
Ankita Singh, Nameirakpam Johnson, Surjit Singh
No abstract text is available yet for this article.
November 8, 2018: International Journal of Rheumatic Diseases
Takuya Matsumoto, Shingo Iwano, Nobunori Takahashi, Shuji Asai, Tatsuo Watanabe, Nobuyuki Asai, Yasumori Sobue, Satoru Ito, Naoki Ishiguro, Toshihisa Kojima
OBJECTIVE: This study aimed to assess the association between chest computed tomography (CT) findings and incidence of respiratory adverse events (RAEs), and to detect risk factors for RAEs, in RA patients treated with long-term biological therapy. METHODS: Clinical and radiological data of 332 RA patients who were treated with biological disease-modifying antirheumatic drugs were collected. CT data were assessed by an experienced radiologist. Patients were categorized into the interstitial lung disease (ILD) group (n = 29), airway disease (AD) group (n = 76), co-existing ILD and AD (Co-existing) group (n = 6), and the group without detectable change (WDC, n = 221) based on CT findings and scores...
November 8, 2018: International Journal of Rheumatic Diseases
Shu-Ping Han, Lin-Shien Fu, Lu-Jen Chen
AIM: Paraneoplastic pemphigus (PNP) is a mucocutaneous autoimmune disorder accompanied with a neoplasm. Castleman's disease (CD), although rare, is the most common cause of PNP in children. It can be life-threatening when pulmonary involvement occurs. Our study aimed to describe the features of PNP resulting from CD and to find clues for the early diagnosis in pediatric patients. METHOD: We report the case of a 13-year-old girl who initially presented with oral ulcers and lichen planus, with progression to respiratory failure...
November 8, 2018: International Journal of Rheumatic Diseases
Nameirakpam Johnson, Ankita Singh, Surjit Singh
No abstract text is available yet for this article.
November 8, 2018: International Journal of Rheumatic Diseases
Hironari Hanaoka, Harunobu Iida, Tomofumi Kiyokawa, Yukiko Takakuwa, Kimito Kawahata
AIM: To assess for any additive value of hydroxychloroquine (HCQ) in Japanese patients with systemic lupus erythematosus (SLE) depending on calcineurin inhibitors (CNIs). METHODS: We retrospectively evaluated patients with SLE who visited our hospital from 2015 to 2016 and were taking prednisolone (PSL) at <20 mg/d and one immunosuppressant (IS). Patients were divided into two groups depending on HCQ use and the groups were compared for changes in SLE Disease Activity Index (SLEDAI), prednisolone (PSL) dose, and cumulative flare rate between patients who were treated and not treated with CNI...
November 8, 2018: International Journal of Rheumatic Diseases
Xiaohui Zhang, Anzhi Xie, Yu Wang, Xuerong Deng, Yan Geng, Lanlan Ji, Yanjie Hao, Guangtao Li, Zhuoli Zhang
AIM: To explore the performance of routine assessment of patient index data 3 (RAPID3) in reflecting disease activity in Chinese rheumatoid arthritis (RA) patients. METHOD: The clinical data of 189 consecutive RA patients, including RAPID3 questionnaire, Disease Activity Score based on 28-joint count (DAS28), clinical disease activity index (CDAI) and simplified disease activity index (SDAI), and ultrasonography of hand and wrist joints were collected. The consistency between RAPID3 and DAS28, CDAI, SDAI in RA patients with different disease activities was performed by Spearman's correlations, kappa and/or weighted kappa coefficients...
November 6, 2018: International Journal of Rheumatic Diseases
Vijai Williams, Amit Rawat, Pandiarajan Vignesh, Jitendra Kumar Shandilya, Anju Gupta, Surjit Singh
BACKGROUND: Polymorphisms in the Fcγ-receptor (FcγR) have been associated with increased susceptibility to systemic lupus erythematosus (SLE). There is a paucity of data on FcγR expression pattern in pediatric subjects with SLE. The aim of the study was to assess the expression of various FcγRs by flow cytometry in children with pediatric-onset SLE (pSLE). METHODS: Thirty-one children aged 0-15 years fulfilling 2012 Systemic Lupus International Collaborating Clinics Classification Criteria for SLE were enrolled...
November 6, 2018: International Journal of Rheumatic Diseases
Takayasu Suzuka, Takuya Kotani, Tohru Takeuchi, Youhei Fujiki, Kenichiro Hata, Shuzo Yoshida, Takeshi Shoda, Shigeki Makino, Shigeki Arawaka
OBJECTIVES: We assessed the efficacy and safety of combination therapy with glucocorticoids and high-trough level tacrolimus (TAC) for the treatment of acute/subacute interstitial pneumonia (A/SIP) in patients with dermatomyositis (DM). METHODS: Eleven DM-A/SIP patients were enrolled. The combination therapy with glucocorticoids and TAC was started as early as possible after DM-A/SIP was diagnosed. We monitored the trough concentration of TAC. In the initial 3 months, we maintained the trough concentration of TAC at relatively high levels within a range of 15-20 ng/mL...
November 5, 2018: International Journal of Rheumatic Diseases
Jun Won Park, Ga Young Ahn, Ji-Won Kim, Eun Seong Park, Ji-Hyoun Kang, Sung Hae Chang, In Ah Choi, Su-Jin Yoo, Jin Kyun Park, Kichul Shin, Yong-Beom Park, Jae-Bum Jun, László Czirják, Yannick Allanore, Marco Matucci-Cerinic, Eun Bong Lee
OBJECTIVES: To investigate the impact of European Scleroderma Trials and Research (EUSTAR) standardized training on the accuracy of modified Rodnan skin score (mRSS) in patients with systemic sclerosis (SSc). METHODS: Eight SSc patients (four diffuse, four limited) and 10 physicians (4 fellows, 6 professors) were included. Gold-standard mRSS was performed by a senior instructor. Training comprised a video presentation and a live demonstration. Each physician performed mRSS with no clinical information in all patients: (a) before training; (b) after video session; and (c) after live demonstration...
November 5, 2018: International Journal of Rheumatic Diseases
Charles Van Liew, Karissa Standridge, Gabriel Leon, Terry A Cronan
AIM: To evaluate pain experiences and memories in fibromyalgia (FM) patients over time. METHOD: Participants included 572 females who were members of a large health maintenance organization who had a diagnosis of FM syndrome (FMS) and met inclusion criteria for the study. Recruitment was for an intervention study that tested the effects of social support and education treatment arms, but there were no treatment effects. Reports of experiential pain (EP), historical peak pain (HPP), and historical valley pain (HVP) for FM were collected...
November 5, 2018: International Journal of Rheumatic Diseases
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