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International Journal of Rheumatic Diseases

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https://www.readbyqxmd.com/read/28524646/cervical-spine-involvement-risk-factors-in-rheumatoid-arthritis-a-meta-analysis
#1
Shuai Zhu, Wangdong Xu, Yubin Luo, Yi Zhao, Yi Liu
AIM: This study aims to discuss risk factors associated with cervical spine involvement (CSI) in patients with rheumatoid arthritis (RA). METHODS: A literature search was performed in Medline, EMBASE, Web of Science and CBMdisc databases for potential studies published before October 2016. The clinical and laboratory data were extracted, and a meta-analysis was performed to evaluate the risk factors for CSI in RA patients. RESULTS: Twelve studies involving a total of 2750 cases with RA and 733 CSI (26...
May 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28524639/high-dose-intravenous-steroid-pulse-therapy-in-ocular-involvement-of-behcet-s-disease-a-pilot-double-blind-control-study
#2
Mastaneh Mohammadi, Farhad Shahram, Hormoz Shams, Massoomeh Akhlaghi, Farimah Ashofteh, Fereydoun Davatchi
AIM: To evaluate the efficacy of intravenous high-dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet's disease (BD). METHOD: In a double-blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Both groups received combination therapy with IV cyclophosphamide, azathioprine and prednisolone for 6 months...
May 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28524619/use-of-complementary-and-alternative-medicines-is-associated-with-delay-to-initiation-of-disease-modifying-anti-rheumatic-drug-therapy-in-early-inflammatory-arthritis
#3
Manjari Lahiri, Amelia Santosa, Lay Kheng Teoh, Jane A Clayton, Sheen Yee Lim, Gim Gee Teng, Peter P M Cheung
OBJECTIVES: To study the predictors of complementary and alternative medicine (CAM) use in patients with early inflammatory arthritis (EIA), and its impact on delay to initiation of disease-modifying anti-rheumatic drugs (DMARD). METHODS: Data were collected prospectively from EIA patients aged ≥ 21 years. Current or prior CAM use was ascertained by face-to-face interview. Predictors of CAM use and its effect on time to DMARD initiation were determined by multivariate logistic regression and Cox proportional hazards, respectively...
May 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28524434/unaffected-reaction-level-in-tuberculin-skin-test-by-long-term-therapy-with-tumor-necrosis-factor-inhibitors-for-rheumatoid-arthritis
#4
Shotaro Yamamoto, Katsuya Nagatani, Takeo Sato, Masahiro Iwamoto, Shino Takatori, Seiji Minota
AIM: The tuberculin skin test (TST) is used to diagnose tuberculosis; however, the influence of tumor necrosis factor (TNF) inhibitors on the test is unclear. This study investigated whether therapy with TNF inhibitors suppresses the TST reaction due to immunosuppression or whether the TST reaction increases due to reactivation of latent Mycobacterium tuberculosis infection. METHOD: Ninety-one patients with rheumatoid arthritis receiving TNF inhibitors (40 using infliximab and 51 using etanercept) were studied...
May 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28523761/unraveling-the-expression-of-microrna-27a-nkg2d-in-peripheral-blood-mononuclear-cells-and-natural-killer-cells-of-pediatric-systemic-lupus-erythematosus-patients
#5
Shady K Sourour, Heba R Aboelenein, Noha M Elemam, Amira K Abdelhamid, Samia Salah, Ahmed I Abdelaziz
BACKGROUND AND AIM: The activity of natural killer (NK) cells is known to be decreased in systemic lupus erythematosus (SLE) patients. Nevertheless, the exact contribution of NK cells in the pathogenesis of SLE is still inconclusive. MicroRNAs (miRNAs), are small noncoding RNA molecules that play a fundamental role in regulating NK cell function. The objective of this study was to investigate the expression of miRNAs that might potentially target an essential activating receptor, NKG2D in peripheral blood mononuclear cells (PBMCs) and NK cells of SLE patients...
May 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28513071/juvenile-idiopathic-arthritis-in-multiplex-families-longitudinal-follow-up
#6
Munira Al Marri, Alya Qari, Sulaiman M Al-Mayouf
OBJECTIVE: To describe the physical, social, educational and employment status and clinical outcomes of patients with juvenile idiopathic arthritis (JIA) from multiplex families. METHODS: All familial JIA patients were treated and had regular follow-up between 1990 and 2015 at King Faisal Specialist Hospital and Research Center (KFSH-RC), Riyadh, were included. Demographic data, disease duration, active arthritis and articular and extra-articular damage at last follow-up visit were reviewed...
May 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28512992/association-of-cd8-t-cells-with-bone-erosion-in-patients-with-rheumatoid-arthritis
#7
Young Bin Joo, Youngho Park, Kwangwoo Kim, So-Young Bang, Sang-Cheol Bae, Hye-Soon Lee
AIM: Bone erosion is a major problem worsening quality of rheumatoid arthritis (RA) patients' lives. However, causal factors responsible for bone erosion in RA have remained unclear. We aimed to examine genetic variants conferring bone erosion in RA using a Korean genome-wide association study (GWAS) and to search for possible biological mechanisms underlying the development of bone erosion. METHOD: We obtained genome-wide single nucleotide polymorphism (SNP) data for 711 Korean RA patients using Illumina HapMap 550v3/660W arrays...
May 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28493422/differences-in-presentation-progression-and-rates-of-arthroplasty-between-hip-and-knee-osteoarthritis-observations-from-an-osteoarthritis-cohort-study-a-clear-role-for-conservative-management
#8
Chamila Dabare, Kim Le Marshall, Albert Leung, Caroline J Page, Peter F Choong, Keith K Lim
AIM: To describe the natural progression and the rates of arthroplasty of a cohort of hip and knee osteoarthritis (OA) patients. METHODS: An observational study of 247 consecutive patients who attended an OA clinic between May 2008 and August 2009. Follow-up survey was conducted from July 2014 to December 2014, with the primary end point being joint replacement surgery. RESULTS: One hundred and sixty-seven patients had knee OA and 80 patients had hip OA...
May 10, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28480561/immunotherapy-induced-sarcoidosis-in-patients-with-melanoma-treated-with-pd-1-checkpoint-inhibitors-case-series-and-immunophenotypic-analysis
#9
Anna J Lomax, Helen M McGuire, Catriona McNeil, Clara J Choi, Peter Hersey, Deme Karikios, Kerwin Shannon, Sebastian van Hal, Urszula Carr, Anne Crotty, Sandeep K Gupta, Jane Hollingsworth, Haewon Kim, Barbara Fazekas de St Groth, Neil McGill
AIM: Sarcoidosis is a multisystem granulomatous disease. This condition has a documented association with the diagnosis of melanoma and can be induced in melanoma patients receiving anti-neoplastic therapy. We evaluated a case series of melanoma patients who developed immunotherapy-induced sarcoidosis. METHODS: Three patients with melanoma (n = 1 resected Stage III, n = 2 metastatic) treated with anti-programmed cell death (PD)-1 antibody therapy at two institutions developed biopsy-proven sarcoidosis...
May 8, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28470851/effectiveness-of-curcuminoids-in-the-treatment-of-knee-osteoarthritis-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#10
Igho J Onakpoya, Elizabeth A Spencer, Rafael Perera, Carl J Heneghan
AIM: To critically appraise and evaluate the evidence for effectiveness of curcuminoids in the treatment of osteoarthritis (OA) in adults. METHODS: We conducted electronic searches in Medline, Embase, AMED, Cinahl and the Cochrane library. We included randomized controlled trials (RCTs) that investigated the effectiveness of orally-administered curcuminoids in OA in adults, and assessed risk of bias using the Cochrane risk of bias criteria. We used a random-effect model for meta-analysis...
May 4, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28470929/down-regulation-of-increased-traf6-expression-in-the-peripheral-mononuclear-cells-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-by-an-ebv-eber1-specific-synthetic-single-stranded-complementary-dna-molecule
#11
Sándor Sipka, Erika Zilahi, Gábor Papp, Ji-Qing Chen, Andrea Nagy, Katalin Hegyi, József Kónya, Margit Zeher
AIM: We described earlier a simultaneously increased that the increased expression of miRNA-146a/b was accompanied by an increase in the expression of and TRAF6 and a decrease in the expression of IRAK1 genes in the peripheral mononuclear cells (PBMCs) of patients with primary Sjogren's syndrome (pSS) patients. Recently, the expression of EBV encoded. RNA (EBER) was published in the B cells of salivary glands of in pSS. In the present study, we applied an EBV-EBER1 specific synthetic single stranded complementary DNA molecule (EBV-EBER1-cDNA) to test whether any EBER1 related effect exists also in PBMCs of pSS patients...
May 3, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28464548/comparison-of-physical-examination-performance-of-medical-students-trained-by-musculoskeletal-versus-non-musculoskeletal-specialists
#12
Luciano Melo, Leslie Schrieber, Jillian Eyles, Leticia A Deveza, Sarah R F Meneses, David J Hunter
AIM: To compare the musculoskeletal (MSK) physical examination skills, knowledge acquisition and performance of first-year medical students trained by MSK specialist tutors to students trained by non-MSK specialist tutors, after a 6-week MSK physical examination tutorial program. METHODS: Twenty-first year medical students took part in the study. They were recruited into two groups, according to their exposure to either an MSK specialist or a non-MSK specialist tutor during their 6-week MSK training block...
May 2, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28464513/phagocyte-activity-in-the-peripheral-blood-of-pregnant-women-with-systemic-lupus-erythematosus-and-in-the-cord-blood-of-their-newborns
#13
Gennady T Sukhikh, Valentina G Safronova, Ludmila V Vanko, Nataliya K Matveeva, Anastasiya S Belyaeva, Ekaterina V Fedorova, Marina A Nikolaeva, Nataliya I Klimenchenko, Lyubov V Krechetova
AIM: To detect faults in phagocytosis in peripheral blood cells of pregnant women with systemic lupus erythematosus (SLE) and in cord blood of their newborns. METHODS: Pregnant women fulfilled ≥ 4 American College of Rheumatology criteria for SLE and their newborns were recruited. Pregnant women without SLE and their newborns constituted controls. Phagocytosis and respiratory burst were measured using PHAGOTEST and BURSTTEST kits (Biotechnology GmbH, Germany) on FACSCalibur™ flow cytometer...
May 2, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28447402/is-extra-glandular-organ-damage-in-primary-sj%C3%A3-gren-s-syndrome-related-to-the-presence-of-systemic-auto-antibodies-and-or-hypergammaglobulinemia-a-long-term-cohort-study-with-110-patients-from-the-netherlands
#14
Evert-Jan Ter Borg, Johannes Cornelis Kelder
AIM: To test the hypothesis that systemic auto-antibodies or hypergammaglobulinemia are related to the prevalence of extra-glandular tissue organ damage (EGOD) in primary Sjögren's syndrome (SS). METHODS: A real practice-based investigation of a relatively large (n = 110) Dutch cohort of primary SS patients systematically followed up in a large non-academic hospital. RESULTS: After a follow up of mean 8.2 years a significant correlation was found between disease duration and the prevalence of EGOD...
April 26, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28447401/valgus-malalignment-and-prevalence-of-lateral-compartmental-radiographic-knee-osteoarthritis-oa-the-wuchuan-oa-study
#15
Bin Wang, Qiang Liu, Barton L Wise, Yan Ke, Dan Xing, Yuankun Xu, Yuqing Zhang, Jianhao Lin
AIM: To evaluate whether knee alignment explains the higher prevalence of lateral compartment tibiofemoral radiographic osteoarthritis (TFROA) among rural Chinese compared with that among Whites. METHODS: The Wuchuan OA Study is a population-based longitudinal study of risk factors for knee OA. At baseline 1030 participants had home interviews, clinical examinations and weight-bearing posteroanterior semi-flexed radiographs of the tibiofemoral joints. Anatomic knee alignment was measured using an e-film workstation and divided into three categories: normal (182°-184°), valgus (> 184°), and varus (< 182°) alignment...
April 26, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28440025/identifying-key-genes-in-rheumatoid-arthritis-by-weighted-gene-co-expression-network-analysis
#16
Chunhui Ma, Qi Lv, Songsong Teng, Yinxian Yu, Kerun Niu, Chengqin Yi
PURPOSE: This study aimed to identify rheumatoid arthritis (RA) related genes based on microarray data using the WGCNA (weighted gene co-expression network analysis) method. METHODS: Two gene expression profile datasets GSE55235 (10 RA samples and 10 healthy controls) and GSE77298 (16 RA samples and seven healthy controls) were downloaded from Gene Expression Omnibus database. Characteristic genes were identified using metaDE package. WGCNA was used to find disease-related networks based on gene expression correlation coefficients, and module significance was defined as the average gene significance of all genes used to assess the correlation between the module and RA status...
April 25, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28425192/soluble-hla-e-a-follow-up-biomarker-in-takayasu-arteritis-independent-of-hla-e-genotype
#17
Ruchika Goel, Jayakanthan Kabeerdoss, Hindhumathi Mohan, Sumita Danda, Visali Jayaseelan, T Sathish Kumar, John Jude, Paul Bacon, George Joseph, Debashish Danda
AIM: Disease activity assessment in Takayasu arteritis (TA) is challenging. Human leukocyte antigen E (HLA-E) is shed from endothelium into serum as a soluble molecule (sHLA-E) in response to inflammation. We aimed to study: (i) utility of sHLA-E as a biomarker of disease activity; and (ii) association of HLA-E polymorphism rs1264457 with clinical disease in Asian-Indian TA patients. MATERIALS AND METHODS: In phase-1, sHLA-E levels were estimated in sera of 50 consecutive TA patients at baseline visit and 27 healthy controls...
April 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28425178/sleep-quality-clinical-and-psychological-manifestations-in-women-with-systemic-lupus-erythematosus
#18
Virginia Moraleda, Germán Prados, María P Martínez, Ana I Sánchez, José M Sabio, Elena Miró
AIM: Sleep problems are a common complaint in systemic lupus erythematosus (SLE) patients. We analyzed sleep quality with subjective and objective measures in a sample with SLE and its possible relationships with the main manifestations of the disease. METHODS: Twenty-one women with SLE and 20 healthy women participated in the study. All participants were evaluated with actigraphy for a week and they completed self-report instruments of sleep quality, quality of life, fatigue, anxiety, depression and perceived stress...
April 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28419763/the-effects-of-local-cold-application-on-fibromyalgia-pain
#19
Naside Yilmaz, Emine Kiyak
AIM: This study was conducted to evaluate the effects of local cold application on pain when applied to the trapezius muscles of patients with fibromyalgia. METHOD: A one-group, pre-test/post-test, pre-experimental model was applied in this study, which was conducted with 55 fibromyalgia patients who presented to a rheumatology outpatient clinic. A 10-min cold application was administered to one trapezius muscle of each patient. The participants' pain was evaluated, in total, four times (before the cold application and 10 min, 1...
April 17, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28419761/pyoderma-gangrenosum-in-sj%C3%A3-gren-s-syndrome-and-its-successful-treatment-with-topical-application-of-etanercept
#20
LETTER
Vikram Haridas, Praveenkumar Shetty, Leonard C Dsouza, U S Dinesh, Kiran Haridas, Anil Bargale
No abstract text is available yet for this article.
April 17, 2017: International Journal of Rheumatic Diseases
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