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Journal of Ovarian Research

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https://www.readbyqxmd.com/read/29132396/circulating-cell-free-dna-and-circulating-tumor-cells-the-liquid-biopsies-in-ovarian-cancer
#1
REVIEW
Xianliang Cheng, Lei Zhang, Yajuan Chen, Chen Qing
Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (cf-DNA) and circulating tumor cells (CTCs) emerging as "liquid biopsies". They represent non-invasive biomarkers and are viable, as they can be isolated from human plasma, serum and other body fluids. Molecular characterization of circulating tumor DNA (ct-DNA) and CTCs offer unique potentials to better understand the biology of metastasis and resistance to therapies...
November 13, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29122003/docosahexaenoic-acid-mechanisms-of-action-on-the-bovine-oocyte-cumulus-complex
#2
Sebastien Elis, Mouhamad Oseikria, Anais Vitorino Carvalho, Priscila Silvana Bertevello, Emilie Corbin, Ana-Paula Teixeira-Gomes, Jérôme Lecardonnel, Catherine Archilla, Véronique Duranthon, Valérie Labas, Svetlana Uzbekova
BACKGROUND: Supplementation of bovine oocyte-cumulus complexes during in vitro maturation (IVM) with 1 μM of docosahexaenoic acid (DHA), C22:6 n-3 polyunsaturated fatty acid, was reported to improve in vitro embryo development. The objective of this paper was to decipher the mechanisms of DHA action. RESULTS: Transcriptomic analysis of 1 μM DHA-treated and control cumulus cells after 4 h IVM showed no significant difference in gene expression. MALDI-TOF mass spectrometry analysis of lipid profiles in DHA-treated and control oocytes and cumulus cells after IVM showed variations of only 3 out of 700 molecular species in oocytes and 7 out of 698 species in cumulus cells (p < 0...
November 9, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29100532/a-comprehensive-overview-of-exosomes-in-ovarian-cancer-emerging-biomarkers-and-therapeutic-strategies
#3
REVIEW
Lin Cheng, Shuying Wu, Kun Zhang, Yun'an Qing, Tianmin Xu
Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the extracellular matrix component through the shuttling of cargo, such as proteins, lipids, RNAs, double-stranded DNAs, non-transcribed RNAs, and microRNAs...
November 3, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29078793/prediction-of-clinical-response-to-drugs-in-ovarian-cancer-using-the-chemotherapy-resistance-test-ctr-test
#4
Frank Christian Kischkel, Carina Meyer, Julia Eich, Mani Nassir, Monika Mentze, Ioana Braicu, Annette Kopp-Schneider, Jalid Sehouli
BACKGROUND: In order to validate if the test result of the Chemotherapy Resistance Test (CTR-Test) is able to predict the resistances or sensitivities of tumors in ovarian cancer patients to drugs, the CTR-Test result and the corresponding clinical response of individual patients were correlated retrospectively. Results were compared to previous recorded correlations. METHODS: The CTR-Test was performed on tumor samples from 52 ovarian cancer patients for specific chemotherapeutic drugs...
October 27, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29061149/a-modified-and-tailored-human-follicle-isolation-procedure-improves-follicle-recovery-and-survival
#5
Maria Costanza Chiti, Marie-Madeleine Dolmans, Maria Hobeika, Alice Cernogoraz, Jacques Donnez, Christiani Andrade Amorim
BACKGROUND: Ovarian tissue cryopreservation followed by transplantation after cancer remission is the most commonly applied fertility restoration approach in very young girls and women who require immediate cancer therapy. However, clinicians strongly advise against reimplantation of one's own ovarian tissue when there is a high risk of recurrence after grafting. For these patients, development of an alternative strategy, namely a transplantable artificial ovary, offers future hope of conceiving...
October 23, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29037231/optimal-parameters-for-determining-the-lh-surge-in-natural-cycle-frozen-thawed-embryo-transfers
#6
Mohamad Irani, Alex Robles, Vinay Gunnala, David Reichman, Zev Rosenwaks
BACKGROUND: There is no consensus on the exact parameters that define the LH surge for natural cycle frozen-thawed embryo transfers (NC-FET). Accurately determining the LH surge would affect the timing, and subsequently the success rates, of embryo transfer. Therefore, the aim of this study was to delineate the optimal levels and relationship for luteinizing hormone (LH) and estradiol in an effort to optimally identify the LH surge in NC-FET. METHODS: It is a retrospective study that was performed in an academic medical center...
October 16, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29021002/collagen-triple-helix-repeat-containing-1-cthrc1-activates-integrin-%C3%AE-3-fak-signaling-and-promotes-metastasis-in-ovarian-cancer
#7
Biying Guo, Huan Yan, Luying Li, Kemin Yin, Fang Ji, Shu Zhang
BACKGROUND: Metastasis is the major cause of morbidity and mortality in patients with epithelial ovarian cancer (EOC), however the mechanisms that underline this process are poorly understood. Collagen triple helix repeat containing-1 (CTHRC1) is a 28-kDa secreted protein reported to be involved in vascular remodeling, bone formation and morphogenesis. This study aimed to investigate the role of CTHRC1 in promoting the metastasis of EOC and to elucidate the underlying molecular mechanisms...
October 11, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28978329/macrophage-colony-stimulating-factor-m-csf-is-an-intermediate-in-the-process-of-luteinizing-hormone-induced-decrease-in-natriuretic-peptide-receptor-2-npr2-and-resumption-of-oocyte-meiosis
#8
Wenchao Sun, Chang Liu, Ying Feng, Guangchao Zhuo, Wenjing Zhou, Xiaoyang Fei, Zhifen Zhang
BACKGROUND: Luteinizing hormone (LH) regulation of the ligand, natriuretic peptide precursor type C, and its receptor, natriuretic peptide receptor 2 (NPR2), is critical for oocyte maturation; however, the mechanism is not fully understood. Macrophage colony-stimulating factor (M-CSF) has recently been shown to be involved in oocyte maturation and ovulation. In the present study we determined whether or not M-CSF plays a role in the intermediate signal that mediates LH regulation of NPR2 in resumption of oocyte meiosis...
October 4, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28974236/endometriosis-is-the-independent-prognostic-factor-for-survival-in-chinese-patients-with-epithelial-ovarian-carcinoma
#9
Tong Ren, Shu Wang, Jian Sun, Ji-Min Qu, Yang Xiang, Keng Shen, Jing He Lang
BACKGROUND: Clinico-pathological characteristics and possible prognostic factors among women with epithelial ovarian carcinoma (EOC) with or without concurrent endometriosis were explored. METHOD: We retrospectively identified 304 patients with EOC treated primarily at Peking Union Medical College Hospital with median follow-up time of 60 months. RESULTS: Of 304 patients with EOC, concurrent endometriosis was identified in 69 (22.7%). The patients with concurrent endometriosis were younger and more probably post-menopausal at onset, were less likely to have abdominal distension, with significantly lower level of pre-surgery serum Ca125 and less possibility of having the history of tubal ligation...
October 3, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28954627/increased-rhamm-expression-relates-to-ovarian-cancer-progression
#10
Stephanie T Buttermore, Mitchel S Hoffman, Ambuj Kumar, Anne Champeaux, Santo V Nicosia, Patricia A Kruk
BACKGROUND: Elevated hyaluronan-mediated motility receptor (RHAMM) has been reported to contribute to disease progression, aggressive phenotype and poor prognosis in multiple cancer types, however, RHAMM's role in ovarian cancer (OC) has not been elucidated. Therefore, we sought to evaluate the role for RHAMM in epithelial OC. RESULTS: Despite little to no expression in normal ovarian surface epithelium, western immunoblotting, immunohistochemical staining and enzyme linked immunosorbent assay showed elevated RHAMM levels in clinical tissue sections, omental metastasis and urine specimens of serous OC patients, as well as in cell lysates...
September 27, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28950890/the-value-of-dce-mri-in-assessing-histopathological-and-molecular-biological-features-in-induced-rat-epithelial-ovarian-carcinomas
#11
Su Juan Yuan, Tian Kui Qiao, Jin Wei Qiang, Song Qi Cai, Ruo Kun Li
BACKGROUND: To investigate dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for assessing histopathological and molecular biological features in induced rat epithelial ovarian carcinomas (EOCs). METHODS: 7,12-dimethylbenz[A]anthracene (DMBA) was applied to induce EOCs in situ in 46 SD rats. Conventional MRI and DCE-MRI were performed to evaluate the morphology and perfusion features of the tumors, including the time-signal intensity curve (TIC), volume transfer constant (K(trans)), rate constant (Kep), extravascular extracellular space volume ratio (Ve) and initial area under the curve (IAUC)...
September 26, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28931403/racial-health-disparities-in-ovarian-cancer-not-just-black-and-white
#12
REVIEW
Sanjeev K Srivastava, Aamir Ahmad, Orlandric Miree, Girijesh Kumar Patel, Seema Singh, Rodney P Rocconi, Ajay P Singh
Ovarian cancer (OC) is the most lethal gynecological malignancy, which disproportionately affects African American (AA) women. Lack of awareness and socioeconomic factors are considered important players in OC racial health disparity, while at the same time, some recent studies have brought focus on the genetic basis of disparity as well. Differential polymorphisms, mutations and expressions of genes have been reported in OC patients of diverse racial and ethnic backgrounds. Combined, it appears that neither genetic nor the socioeconomic factors alone might explain the observed racially disparate health outcomes among OC patients...
September 21, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28927438/activated-ovarian-endothelial-cells-promote-early-follicular-development-and-survival
#13
Alon Kedem, Anate Aelion-Brauer, Peipei Guo, Duancheng Wen, Bi-Sen Ding, Raphael Lis, Du Cheng, Vladislav M Sandler, Shahin Rafii, Zev Rosenwaks
BACKGROUND: New data suggests that endothelial cells (ECs) elaborate essential "angiocrine factors". The aim of this study is to investigate the role of activated ovarian endothelial cells in early in-vitro follicular development. METHODS: Mouse ovarian ECs were isolated using magnetic cell sorting or by FACS and cultured in serum free media. After a constitutive activation of the Akt pathway was initiated, early follicles (50-150 um) were mechanically isolated from 8-day-old mice and co-cultured with these activated ovarian endothelial cells (AOEC) (n = 32), gel (n = 24) or within matrigel (n = 27) in serum free media for 14 days...
September 19, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28923080/prognostic-analysis-for-chinese-patients-with-stage-i-ovarian-endometrioid-carcinoma
#14
Yu Zhao, Shu Wang, Yi-Min Qu, Yu-Ting Ji, Keng Shen, Jing He Lang
BACKGROUND: This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. METHODS: The present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of ovarian endometrioid carcinoma at our center. In all, 78 patients had stage I ovarian endometrioid carcinoma. RESULTS: In this series, the 5-year overall survival rate and 5-year disease-free survival (DFS) rates of patients with stage I ovarian endometrioid carcinoma was 98...
September 18, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28915843/protective-effects-of-gaba-against-metabolic-and-reproductive-disturbances-in-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#15
Asad Ullah, Sarwat Jahan, Suhail Razak, Madeeha Pirzada, Hizb Ullah, Ali Almajwal, Naveed Rauf, Tayyaba Afsar
BACKGROUND: PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries as the key diagnostic feathers. The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance. METHODS: PCOs in Adult female rat was induced by the daily gastric administration of letrozole (1 mg/kg/day) in CMC (0...
September 15, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28915830/biological-effects-of-combined-resveratrol-and-vitamin-d3-on-ovarian-tissue
#16
Francesca Uberti, Vera Morsanuto, Silvio Aprile, Sabrina Ghirlanda, Ian Stoppa, Andrea Cochis, Giorgio Grosa, Lia Rimondini, Claudio Molinari
BACKGROUND: Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural antioxidant polyphenol able to exert a wide range of biological effect on several tissues. Despite its important beneficial properties, it has a low water solubility, which limits its therapeutic applications in humans. Resveratrol also acts as a phytoestrogen that modulates estrogen receptor (ER)-mediated transcription. In addition, it has been shown that ovarian tissues benefit greatly from vitamin D3, which exerts its beneficial effects through VDR receptors...
September 15, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28899430/the-aberrant-upstream-pathway-regulations-of-cdk1-protein-were-implicated-in-the-proliferation-and-apoptosis-of-ovarian-cancer-cells
#17
Ruitao Zhang, Huirong Shi, Fang Ren, Minghui Zhang, Pengcheng Ji, Wenwen Wang, Chuanna Liu
BACKGROUND: Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase regulation. The present study aimed to analyze the relationship between CDK1 and the proliferation and apoptosis of ovarian cancer cells, investigate its molecular mechanism preliminarily. METHODS: The specific short-hair RNA (shRNA) plasmids and negative control plasmid of CDK1, checkpoint kinase 1 (CHK1) and p53 genes were transfected into ovarian cancer SK-OV-3 and OVCAR-3 cells respectively...
September 12, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28893324/selecting-treatment-method-for-ovarian-masses-in-children-24%C3%A2-years-of-experience
#18
Justyna Łuczak, Maciej Bagłaj
BACKGROUND: Epidemiology and pathology of ovarian tumors in the pediatric population are very different of these encountered in women. Few attempts have been made to analyze the whole spectrum of ovarian pathology in children, and only some of them included series of more than 200 cases. We performed a retrospective analysis of clinical and diagnostic aspects of ovarian tumors and tumor-like lesions in girls in order to identify the characteristics associated with malignancy with an attempt to elaborate a clinical management algorithm...
September 11, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28830564/availability-of-healthcare-resources-and-epithelial-ovarian-cancer-stage-of-diagnosis-and-mortality-among-blacks-and-whites
#19
Swati Sakhuja, Huifeng Yun, Maria Pisu, Tomi Akinyemiju
BACKGROUND: The purpose of this study is to examine whether racial disparities in epithelial ovarian cancer stage at diagnosis and survival may be explained by geographic availability of healthcare resources among Blacks and Whites. METHODS: Data from the Surveillance, Epidemiology and End Results (SEER) database was used to identify White and Black women ages 40 years and above diagnosed with epithelial ovarian cancer between 2000 and 2010. Data on county-level availability of healthcare resources was obtained from the Area Resource File...
August 22, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28814333/rapamycin-prevents-cyclophosphamide-induced-over-activation-of-primordial-follicle-pool-through-pi3k-akt-mtor-signaling-pathway-in-vivo
#20
Linyan Zhou, Yanqiu Xie, Song Li, Yihua Liang, Qi Qiu, Haiyan Lin, Qingxue Zhang
BACKGROUND: Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential mechanism for patients receiving chemotherapy. METHODS: 8-week old BALB/c female mice were randomly assigned into four groups (control; rapamycin; cyclophosphamide; and rapamycin combined with cyclophosphamide). Hematoxylin staining, immunohistochemical, TUNEL, western blotting and ELISA were employed to assess inter-group differences using Student's t-test and Mann-Whitney test...
August 16, 2017: Journal of Ovarian Research
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