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Journal of Ovarian Research

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https://www.readbyqxmd.com/read/29759079/s-allylcysteine-suppresses-ovarian-cancer-cell-proliferation-by-dna-methylation-through-dnmt1
#1
Yasi Xu, Dan Su, Lucheng Zhu, Shirong Zhang, Shenglin Ma, Kan Wu, Qiang Yuan, Nengming Lin
BACKGROUND: The anti-tumor effects of S-allylcysteine (SAC), a water-soluble garlic derivative, on human ovarian cancer cells have been previous studied in vitro and in vivo models but the precise epigenetic molecular mechanisms are still unclear. This study aimed to investigate the epigenetic mechanism of SAC. METHODS: Human epithelial ovarian cancer cell line A2780 was selected. Cell proliferation and cell cycle was analyzed. DNA methylation, DNA methyltransferase (DNMT) activity, tumor suppressor gene expressions, as well as protein expression were analyzed...
May 14, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29747700/effects-of-myo-inositol-plus-alpha-lactalbumin-in-myo-inositol-resistant-pcos-women
#2
Mario Montanino Oliva, Giovanna Buonomo, Marco Calcagno, Vittorio Unfer
BACKGROUND: Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also considering its anti-inflammatory effect. METHODS: PCOS patients, according to the Rotterdam ESHRE-ASRM criteria, with anovulation and infertility > 1 year, were included in this open and prospective study. The preliminary phase was aimed at determining a set of MI-resistant PCOS patients...
May 10, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29728130/low-dose-clomiphene-citrate-as-a-mild-stimulation-protocol-in-women-with-unsuspected-poor-in-vitro-fertilization-result-can-generate-more-oocytes-with-optimal-cumulative-pregnancy-rate
#3
Humphrey Ochin, Xiang Ma, Lin Wang, Xuan Li, Jie Song, Yan Meng, Jiandong Shen, Yu-Gui Cui, Jiayin Liu
BACKGROUND: The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affects its quality and compromises the treatment outcome. Mild stimulation protocols that attract low dose gonadotropins could be useful alternative regimen to address such problems. This study evaluated the efficacy of low dose clomiphene citrate based protocol plus low dose gonadotropins on predicted normal responder patients who had unsuspected poor in vitro fertilization (IVF) result, following an initial stimulation with long gonadotropin-releasing hormone (GnRH) agonist protocol...
May 4, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29716634/successful-fertility-following-optimized-perfusion-and-cryopreservation-of-whole-ovary-and-allotransplantation-in-a-premature-ovarian-insufficiency-rat-model
#4
Yan Ding, Jia-Liang Shao, Jun-Wei Li, Ying Zhang, Kai-Hua Hong, Ke-Qin Hua, Xiang Wang
BACKGROUND: Fertility preservation by whole ovary cryopreservation and transplantation (WOCP&TP) with vascular anastomosis requires successful cryopreservation. In this study, we investigated the possibility of restoring ovarian function and natural fertility after WOCP&TP in a premature ovarian insufficiency (POI) rat model. The influence of cryopreservation on the offspring of rats following WOCP&TP was also explored. METHOD: Rats aged 8-10 weeks were used as donors and recipients for allotransplantation...
May 2, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29716628/nanog-interaction-with-the-androgen-receptor-signaling-axis-induce-ovarian-cancer-stem-cell-regulation-studies-based-on-the-crispr-cas9-system
#5
Kaijian Ling, Lupin Jiang, Shi Liang, Joseph Kwong, Leiyan Yang, Yudi Li, PingYin, Qingchun Deng, Zhiqing Liang
BACKGROUND: Ovarian cancer stem cells (OCSCs) contribute to the poor prognosis of ovarian cancer. Involvement of the androgen receptor (AR) in the malignant behaviors of other tumors has been reported. However, whether AR associates with Nanog (a stem cell marker) and participates in OCSC functions remain unclear. In this study, we investigated the interaction of Nanog with AR and examined whether this interaction induced stem-like properties in ovarian cancer cells. METHODS: AR and Nanog expression in ovarian tumors was evaluated...
May 2, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29716627/microrna-424-503-cluster-members-regulate-bovine-granulosa-cell-proliferation-and-cell-cycle-progression-by-targeting-smad7-gene-through-activin-signalling-pathway
#6
Hari Om Pande, Dawit Tesfaye, Michael Hoelker, Samuel Gebremedhn, Eva Held, Christiane Neuhoff, Ernst Tholen, Karl Schellander, Dessie Salilew Wondim
BACKGROUND: The granulosa cells are indispensable for follicular development and its function is orchestrated by several genes, which in turn posttranscriptionally regulated by microRNAs (miRNA). In our previous study, the miRRNA-424/503 cluster was found to be highly abundant in bovine granulosa cells (bGCs) of preovulatory dominant follicle compared to subordinate counterpart at day 19 of the bovine estrous cycle. Other study also indicated the involvement of miR-424/503 cluster in tumour cell resistance to apoptosis suggesting this miRNA cluster may involve in cell survival...
May 1, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29699594/beneficial-effects-of-curcumin-and-capsaicin-on-cyclophosphamide-induced-premature-ovarian-failure-in-a-rat-model
#7
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Asli Cetin, Nese Basak
BACKGROUND: In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regarding the preservation and restoration of ovarian function before and after oncological treatment because of the reproductive risk of chemotherapeutics and improved long-term survival of cancer patients. In this study, we sought to analyze the effects of curcumin (CRC) and capsaicin (CPS) on cyclophosphamide-induced POF in a rat model...
April 26, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29690914/klk10-exon-3-unmethylated-pcr-product-concentration-a-new-potential-early-diagnostic-marker-in-ovarian-cancer-a-pilot-study
#8
Mustafa A El Sherbini, Amal A Mansour, Maha M Sallam, Emtiaz A Shaban, Zeinab A Shehab ElDin, Amr H El-Shalakany
BACKGROUND: KLK10 exon 3 hypermethylation correlated to tumor-specific lack of KLK10 expression in cancer cell lines and primary tumors. In the present study we investigate the possible role of KLK10 exon 3 methylation in ovarian tumor diagnosis and prognosis. RESULTS: Qualitative methylation-specific PCR (MSP) results did not show statistically significant differences in patient group samples (normal and tumor) where all samples were positive only for the unmethylated-specific PCR except for two malignant samples that were either doubly positive (serous carcinoma) or doubly negative (Sertoli-Leydig cell tumor) for the two MSP tests...
April 24, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29685168/role-of-bmi1-in-epithelial-ovarian-cancer-investigated-via-the-crispr-cas9-system-and-rna-sequencing
#9
Qianying Zhao, Qiuhong Qian, Dongyan Cao, Jiaxin Yang, Ting Gui, Keng Shen
BACKGROUND: B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) might be an appropriate biomarker in the management of epithelial ovarian cancer (EOC). However, the biological role of BMI1 and its relevant molecular mechanism needs further elaboration. Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system is an excellent genome-editing tool and is scarcely used in EOC studies. METHODS: We first applied CRISPR/Cas9 technique to silence BMI1 in EOC cells; thereafter we accomplished various in vivo and in vitro experiments to detect biological behaviors of ovarian cancer cells, including MTT, flow cytometry, Transwell, real-time polymerase chain reaction and western blotting assays, etc...
April 23, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29673382/risk-of-synchronous-endometrial-disorders-in-women-with-endometrioid-borderline-tumors-of-the-ovary
#10
Shuang-Zheng Jia, Jun-Ji Zhang, Jun-Jun Yang, Yang Xiang, Zhiyong Liang, Jin-Hua Leng
BACKGROUND: Synchronous endometrial disorders have been poorly studied in women with endometrioid borderline ovarian tumors (EBOT). The aims of this study were to investigate the risk of endometrial disorders among women with EBOT and associated factors, as well as their oncological and fertility outcomes. RESULTS: This retrospective study included 33 women with EBOT. Their mean age was 41.9 years, and endometria were evaluated in 25 of these patients. The prevalence of synchronous endometrial disorders was 52...
April 19, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29642915/adipokine-rbp4-drives-ovarian-cancer-cell-migration
#11
Yanyan Wang, Yilin Wang, Zhenyu Zhang
BACKGROUND: Obesity has been linked to several types of cancers including ovarian cancer. Retinol binding protein 4 (RBP4) is an adipokine that drives the development of hyperinsulinemia and type II diabetes in obesity patients and animals. Previously, we have identified RBP4 as a serum marker for ovarian cancer. Here we further explored the consequence of RBP4 upregulation in ovarian cancer cells and its molecular mechanism. RESULTS: Our results show that RBP4 is overexpressed in ovarian cancer cells to the same extent as in adipose tissues...
April 11, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29636080/transparency-in-ovarian-cancer-clinical-trial-results-clinicaltrials-gov-versus-pubmed-embase-and-google-scholar
#12
Anna Roberto, Silvia Radrezza, Paola Mosconi
BACKGROUND: In recent years the question of the lack of transparency in clinical research has been debated by clinicians, researchers, citizens and their representatives, authors and publishers. This is particularly important for infrequent cancers such as ovarian cancer, where treatment still gives disappointing results in the majority of cases. Our aim was to assess the availability to the public of results in ClinicalTrials.gov, and the frequency of non-publication of results in ClinicalTrials...
April 10, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29618387/deregulation-of-the-spindle-assembly-checkpoint-is-associated-with-paclitaxel-resistance-in-ovarian-cancer
#13
Taryne Chong, Amila Sarac, Cindy Q Yao, Linda Liao, Nicola Lyttle, Paul C Boutros, John M S Bartlett, Melanie Spears
BACKGROUND: Ovarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need for chemotherapy. Ovarian cancer is frequently sensitive to chemotherapy at diagnosis but rapid development of drug resistance leads to disease progression and ultimately death in the majority of patients. RESULTS: We have generated paclitaxel resistant ovarian cell lines from their corresponding native cell lines to determine driver mechanisms of drug resistance using gene expression arrays...
April 4, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29615083/therapeutic-potentials-of-quercetin-in-management-of-polycystic-ovarian-syndrome-using-letrozole-induced-rat-model-a-histological-and-a-biochemical-study
#14
Sarwat Jahan, Abira Abid, Sidra Khalid, Tayyaba Afsar, Qurat-Ul-Ain, Ghazala Shaheen, Ali Almajwal, Suhail Razak
BACKGROUND: PCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects of quercetin in a letrozole induced rat model of polycystic ovarian syndrome, which displayed both clinical and metabolic features as in PCOS women. METHODS: Female Sprague Dawley (SD) rats were divided into four groups; control group received aqueous solution of carboxymethyl (CMC 0...
April 3, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29587835/is-adjuvant-chemotherapy-beneficial-for-patients-with-figo-stage-ic-adult-granulosa-cell-tumor-of-the-ovary
#15
Dan Wang, Yang Xiang, Ming Wu, Keng Shen, Jiaxin Yang, Huifang Huang, Tong Ren
BACKGROUND: To evaluate the association between adjuvant chemotherapy and clinical outcomes in patients with stage IC adult granulosa cell tumor (AGCT). METHODS: We performed a retrospective study of patients with stage IC AGCT diagnosed at our hospital from January 1985 to September 2015. We analyzed descriptive statistics, and performed univariate and multivariate and Kaplan-Meier survival analyses. RESULTS: Sixty stage IC AGCT patients were identified, including 28 in the no adjuvant chemotherapy group (NACG) and 32 in the adjuvant chemotherapy group (ACG)...
March 27, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29580285/pioglitazone-is-effective-for-multiple-phenotyepes-of-the-zucker-fa-fa-rat-with-polycystc-ovary-morphology-and-insulin-resistance
#16
Miyuki Morishita, Toshiaki Endo, Tsuyoshi Baba, Yoshika Kuno, Keiko Ikeda, Tamotsu Kiya, Hiroyuki Honnma, Tsuyoshi Saito
BACKGROUND: Hyperandrogenism and insulin resistance may be related to the etiology of PCOS. Zucker fa/fa rats with polycystic ovary are obese, have insulin resistance without diabetes mellitus or hyperandrogenism and can be utilized as PCOS model rats without effects of hyperandrogenemia. PCOS patients are reported to have elevated levels of serum anti-Mullerian hormone (AMH), which has an inhibitory action on folliculogenesis, and low levels of serum adiponectin, which blocks apoptosis and induces biological effects in some tissues...
March 27, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29548330/with-low-ovarian-reserve-highly-individualized-egg-retrieval-hier-improves-ivf-results-by-avoiding-premature-luteinization
#17
Yan-Guang Wu, David H Barad, Vitaly A Kushnir, Qi Wang, Lin Zhang, Sarah K Darmon, David F Albertini, Norbert Gleicher
BACKGROUND: Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be for administration of ovulation-triggers. METHODS: Fifty-six women ≥43, and 37 POA patients underwent IVF cycles. Granulosa cells (GCs) were isolated, cultures were established, RNA was extracted and real-time PCR analyses performed, with gene expressions at mRNA level investigated for FSH receptor (FSHR), luteinizing hormone receptor (LHCPR), P450 aromatase (CYP19a1) and progesterone receptor (PGR)...
March 16, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29510732/cross-linked-hyaluronan-gel-inhibits-the-growth-and-metastasis-of-ovarian-carcinoma
#18
Ji Pang, Pengcheng Jiang, Ying Wang, Lu Jiang, Hai Qian, Yan Tao, Ruxia Shi, Jizong Gao, Yongchang Chen, Yan Wu
BACKGROUND: The recurrence, metastasis and poor prognosis are important characteristics of ovarian carcinoma (OC), which are associated with exfoliation of cells from the primary tumor and colonization of the cells in pelvic cavity. On the other hand, the life quality of the patients undergoing surgical resection of OC was influenced by postoperative adhesions. Therefore, preventing postoperative implant tumor and adhesion may be effective methods to improve OC treatment. HyaRegen Gel, a cross-linked hyaluronan gel (CHAG), has been widely used as an anti-adhesive agent following pelvic operation in clinic...
March 6, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29506569/does-the-primary-route-of-spread-have-a-prognostic-significance-in-stage-iii-non-serous-epithelial-ovarian-cancer
#19
Hanifi Sahin, Mehmet Mutlu Meydanli, Mustafa Erkan Sari, Ibrahim Yalcin, Gonca Çoban, Nazlı Topfedaisi Ozkan, Zeliha Firat Cuylan, Baki Erdem, Kemal Gungorduk, Özgür Akbayir, Murat Dede, Mustafa Coşkun Salman, Tayfun Güngör, Ali Ayhan
BACKGROUND: The purpose of this retrospective study was to determine the prognosis of non-serous epithelial ovarian cancer (EOC) patients with exclusively retroperitoneal lymph node (LN) metastases, and to compare the prognosis of these women to that of patients who had abdominal peritoneal involvement. METHODS: A multicenter, retrospective department database review was performed to identify patients with stage III non-serous EOC at 7 gynecologic oncology centers in Turkey...
March 5, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29499737/comparison-of-benign-peritoneal-fluid-and-ovarian-cancer-ascites-derived-extracellular-vesicle-rna-biomarkers
#20
Cindy M Yamamoto, Melanie L Oakes, Taku Murakami, Michael G Muto, Ross S Berkowitz, Shu-Wing Ng
BACKGROUND: Extracellular vesicles (EVs) are considered as a new class of resources for potential biomarkers. We analyzed expression of specific mRNA and miRNA in EVs derived from ovarian cancer ascites and the ideal controls, peritoneal fluids from benign patients for potential early detection and prognostic biomarkers. METHODS: Fluids were collected from subjects with benign cysts or endometrioma (n = 10), or low/high grade serous ovarian carcinoma (n = 8)...
March 2, 2018: Journal of Ovarian Research
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