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Journal of Ovarian Research

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https://www.readbyqxmd.com/read/28645304/validation-of-an-automated-technique-for-ovarian-cortex-dissociation-isolation-of-viable-ovarian-cells-and-their-qualification-by-multicolor-flow-cytometry
#1
Tristan Zver, Elodie Mouloungui, Aurélie Berdin, Christophe Roux, Clotilde Amiot
BACKGROUND: Ovarian tissue cryopreservation is a technique for fertility preservation addressed to prepubertal girls or to patients for whom no ovarian stimulation is possible before initiation of gonadotoxic treatments. Autotransplantation of frozen-thawed ovarian tissue is the only available option for reuse but presents some limitations: ischemic tissue damages post-transplant and reintroduction of malignant cells in cases of cancer. It is therefore essential to qualify ovarian tissue before autograft on a functional and oncological point of view...
June 23, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28629378/microrna-130b-is-involved-in-bovine-granulosa-and-cumulus-cells-function-oocyte-maturation-and-blastocyst-formation
#2
Pritam Bala Sinha, Dawit Tesfaye, Franca Rings, Munir Hossien, Michael Hoelker, Eva Held, Christaine Neuhoff, Ernst Tholen, Karl Schellander, Dessie Salilew-Wondim
BACKGROUND: Oocyte maturation and preimplantation embryo development are controlled by array of genes that are post-transcriptionally regulated by microRNAs. With respect to this, previously, we identified altered expression of microRNA-130b (miR-130b) during oocyte maturation. Here, we aimed to investigate the role of miR-130b in bovine granulosa and cumulus cell function, oocyte maturation and preimplantation embryo development using gain- and loss-of- function approach. METHODS: For this study, the granulosa cells, cumulus cells and the oocytes were collected from ovaries obtained from slaughterhouse...
June 19, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28606125/age-is-associated-with-prognosis-in-serous-ovarian-carcinoma
#3
Fei Deng, Xia Xu, Mengmeng Lv, Binhui Ren, Yan Wang, Wenwen Guo, Jifeng Feng, Xiaoxiang Chen
PURPOSE: The survival duration of elderly patients with epithelial ovarian carcinoma is shorter than that of their younger counterparts. This variation in survival duration is likely attributed to differences in the distribution of histological type or grade, International Federation of Gynecology and Obstetrics (FIGO) staging, and undertreatment, but this observation remains controversial. This study aimed to investigate the biological factors other than selection bias associated with the decreased survival of elderly patients with ovarian carcinoma...
June 12, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28511712/what-we-learned-from-extended-culture-of-rejected-day-3-cleavage-stage-embryos-a-prospective-cohort-study
#4
Anat Hershko Klement, Michal Ovadia, Amir Wiser, Arie Berkovitz, Tal Shavit, Luba Nemerovsky, Yehudith Ghetler, Ilan Cohen, Adrian Shulman
BACKGROUND: To test whether poor quality day-3 embryos can undergo successful blastulation and implantation. METHODS: A prospective cohort study was conducted. Whether or not a good quality embryo was transferred on day-3, poor quality (rejected) embryos were further cultured and followed. The clinical outcome of each embryo was assessed. RESULTS: A total of 694 rejected embryos (from 205 patients) were included, with a blastulation rate of 21...
May 16, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28494798/androstenedione-response-to-recombinant-human-fsh-is-the-most-valid-predictor-of-the-number-of-selected-follicles-in-polycystic-ovarian-syndrome-a-case-control-study
#5
Eser Sefik Ozyurek, Tevfik Yoldemir, Gokhan Artar
BACKGROUND: We aimed to test the hypothesis that the correlation of the changes in the blood Androstenedione (A4) levels to the number of selected follicles during ovulation induction with low-dose recombinant human follicle stimulating hormone (rhFSH) is as strong as the correlation to changes in the blood Estradiol (E2) levels in polycystic ovary syndrome (PCOS). METHODS: Prospective Case-control study conducted from October 2014 to January 2016. 61 non-PCOS control (Group I) and 46 PCOS (Group II) patients treated with the chronic low-dose step up protocosl with rhFSH...
May 12, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28476165/microrna-205-promotes-cell-invasion-by-repressing-tcf21-in-human-ovarian-cancer
#6
Jun Wei, Lahong Zhang, Jennifer Li, Shuguang Zhu, Minghui Tai, Clifford W Mason, Julia A Chapman, Evelyn A Reynolds, Carl P Weiner, Helen H Zhou
BACKGROUND: Ovarian cancer is the leading lethal, gynecological malignancy in the United States. No doubt, the continued morbidity and mortality of ovarian cancer reflects a poor understanding of invasive mechanisms. Recent studies reveal that ovarian cancers express aberrant microRNAs (miRNAs or miRs), some of which have oncogenic or tumor suppressor properties. Several studies suggested that miR-205 is involved in tumorigenesis. Presently, we investigate the molecular mechanisms and target of miR-205 in ovarian cancer...
May 5, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28472976/the-effect-of-dehydroepiandrosterone-supplementation-on-ovarian-response-is-associated-with-androgen-receptor-in-diminished-ovarian-reserve-women
#7
Qiaofei Hu, Liming Hong, Mingyue Nie, Qin Wang, Ying Fang, Yinmei Dai, Yanhong Zhai, Shuyu Wang, Chenghong Yin, Xiaokui Yang
BACKGROUND: Diminished ovarian reserve(DOR) is associated with female infertility and poor response to ovarian stimulation. Our objective was to assess the effect of dehydroepiandrosterone(DHEA) on DOR women and to explore whether the improvement of ovarian response after DHEA supplementation was dependent on the expression levels of androgen receptor(AR). METHODS: A prospective cohort study was performed in the Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital during August 2014 to August 2016...
May 4, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28446239/dasatinib%C3%A2-%C3%A2-gefitinib-a-non-platinum-based-combination-with-enhanced-growth-inhibitory-anti-migratory-and-anti-invasive-potency-against-human-ovarian-cancer-cells
#8
Benoît Thibault, Bertrand Jean-Claude
BACKGROUND: Ovarian cancer is the leading cause of death for gynecological cancers and the 6th cause of women cancer death in developed countries. The late stage detection, the peritoneal dissemination and the acquisition of resistance against carboplatin are the main reasons to explain this poor prognosis and strengthen the need of alternative treatments to improve the management of ovarian cancer and/or to sensitize tumors to platinum salts. Epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (Met) and cellular Src kinase (c-Src) are crucial kinases implied in ovarian tumor growth, survival, invasion and resistance to carboplatin...
April 26, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28438190/very-small-embryonic-like-stem-cells-vsels-in-adult-mouse-uterine-perimetrium-and-myometrium
#9
Deepa Bhartiya, Kreema James
We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and remodeling of the endometrium. Present study is a brief communication wherein we have examined the effect of higher dose of estrogen (E, 2 μg/day), progesterone (P, 1 mg/day) and follicle stimulating hormone (FSH, 5 IU/day for 5 days) specifically on the myometrium and perimetrium surrounding the endometrium in bilaterally ovariectomized mice...
April 24, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28438188/luteinizing-hormone-elevation-in-ovarian-granulosa-cell-tumor-a-case-report-and-review-of-the-literature
#10
Shengyuan Ran, Qi Yu, Shan Deng, Ling Xu
BACKGROUND: Ovarian granulosa cell tumors (GCTs) are the most common type of potentially malignant ovarian sex cord-stromal tumor. GCTs often produce estrogen and/or progesterone; consequently, symptoms related to hyperestrogenism are common at diagnosis. Nonspecific symptoms or signs associated with this neoplasm include amenorrhea and changes in various sex hormone levels, which can be hard to diagnose or explain. The aims of this report were to describe a case of GCT with rare presentations and to review the pertinent literature...
April 24, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28427435/prohibitin-targeting-peptide-coupled-to-ovarian-cancer-luteinization-and-tgf-%C3%AE-pathways
#11
Nour M El-Etreby, Amany A Ghazy, Radwaa Rashad
BACKGROUND: Ovarian epithelial tumor (OET) is a silent disease of late diagnosis and poor prognosis. Currently treatment options are limited and patient response to treatment is difficult to predict so there is a serious need to delineate the real pathogenesis to predict tumour prognosis. Prohibitin (PHB) is an evolutionarily protein that regulates the cell cycle. TGF-β has been shown to be a positive and negative regulator of cellular proliferation and differentiation. The present study provides an overview on the role played by PHB1, TGF-β and LH in ovarian cancer...
April 20, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28407786/bioinformatics-analysis-to-screen-the-key-prognostic-genes-in-ovarian-cancer
#12
Li Li, Shengyun Cai, Shengnan Liu, Hao Feng, Junjie Zhang
BACKGROUND: Ovarian cancer (OC) is a gynecological oncology that has a poor prognosis and high mortality. This study is conducted to identify the key genes implicated in the prognosis of OC by bioinformatic analysis. METHODS: Gene expression data (including 568 primary OC tissues, 17 recurrent OC tissues, and 8 adjacent normal tissues) and the relevant clinical information of OC patients were downloaded from The Cancer Genome Atlas database. After data preprocessing, cluster analysis was conducted using the ConsensusClusterPlus package in R...
April 13, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28388957/hbxip-overexpression-is-correlated-with-the-clinical-features-and-survival-outcome-of-ovarian-cancer
#13
Yixuan Wang, Jie Sun, Nan Li, Shuanlong Che, Tiefeng Jin, Shuangping Liu, Zhenhua Lin
BACKGROUND: Accumulated evidence has demonstrated that Mammalian hepatitis B X-interacting protein (HBXIP) has broad roles in cancer. Although HBXIP is associated with a variety of cancers, the HBXIP protein expression level and its clinical significance in ovarian cancer have not yet been determined. The aim of this study is to investigate the association between HBXIP expression and the clinicopathological features of ovarian cancer patients to determine whether HBXIP may be correlated with a poor prognosis in ovarian cancer patients...
April 7, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28376925/serum-and-peritoneal-fluid-concentrations-of-soluble-human-leukocyte-antigen-tumor-necrosis-factor-alpha-and-interleukin-10-in-patients-with-selected-ovarian-pathologies
#14
Olimpia Sipak-Szmigiel, Piotr Włodarski, Elżbieta Ronin-Walknowska, Andrzej Niedzielski, Beata Karakiewicz, Sylwia Słuczanowska-Głąbowska, Maria Laszczyńska, Witold Malinowski
BACKGROUND: Although immune system plays a key role in the pathogenesis of both endometriosis and ovarian cancer, its function is different. Therefore, we hypothesized, that selected immune parameters can serve as diagnostic markers of these two conditions. The aim of this study was to compare serum and peritoneal fluid concentrations of sHLA-G, IL-10 and TNF-alpha in women with selected ovarian pathologies: benign serous cysts, endometrioma and malignant tumors. Clinical significance of using them for diagnostic purposes in women with serous ovarian cysts, endometriosis, and ovarian cancer, which in the future may improve the early diagnosis of ovarian diseases...
April 4, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28376898/identification-of-factors-that-impact-recurrence-in-patients-with-borderline-ovarian-tumors
#15
Xi Chen, Chenyan Fang, Tao Zhu, Ping Zhang, Aijun Yu, Shihua Wang
BACKGROUND: The lack of consensus around best practices for management of borderline ovarian tumors (BOT) is, in part, to the lack of available data and of clarity in interpreting relationships among various factors that impact outcomes. The objective of this study was to identify clinicopathological factors that impact prognosis of patients with borderline ovarian tumors (BOT) and to address features of this disease with the objective of providing clarity in decision making around management of BOT...
April 4, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28376831/let-7e-sensitizes-epithelial-ovarian-cancer-to-cisplatin-through-repressing-dna-double-strand-break-repair
#16
Man Xiao, Jing Cai, Liqiong Cai, Jinghui Jia, Lisha Xie, Ying Zhu, Bangxing Huang, Dongdong Jin, Zehua Wang
BACKGROUND: Resistance to platinum-based chemotherapy remains a great challenge for ovarian cancer treatment. The human let-7 family contains 13 members located on nine different chromosomes, and most members have been implicated in the modulation of drug sensitivity in cancers. Our previous study showed that deregulation of let-7e in epithelial ovarian cancer (EOC) promoted the development of resistance to cisplatin. In the present study, we aimed to investigate the underlying mechanism and further evaluate the clinical value of let-7e in predicting chemo-response and prognosis in EOC...
April 4, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28347334/is-the-hypothesis-of-preimplantation-genetic-screening-pgs-still-supportable-a-review
#17
REVIEW
Norbert Gleicher, Raoul Orvieto
The hypothesis of preimplantation genetic diagnosis (PGS) was first proposed 20 years ago, suggesting that elimination of aneuploid embryos prior to transfer will improve implantation rates of remaining embryos during in vitro fertilization (IVF), increase pregnancy and live birth rates and reduce miscarriages. The aforementioned improved outcome was based on 5 essential assumptions: (i) Most IVF cycles fail because of aneuploid embryos. (ii) Their elimination prior to embryo transfer will improve IVF outcomes...
March 27, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28347324/pms2-gene-mutation-results-in-dna-mismatch-repair-system-failure-in-a-case-of-adult-granulosa-cell-tumor
#18
Wen-Chung Wang, Ya-Ting Lee, Yen-Chein Lai
BACKGROUND: Granulosa cell tumors are rare ovarian malignancies. Their characteristics include unpredictable indolent growth with malignant potential and late recurrence. Approximately 95% are of adult type. Recent molecular studies have characterized the FOXL2 402C > G mutation in adult granulosa cell tumor. Our previous case report showed that unique FOXL2 402C > G mutation and defective DNA mismatch repair system are associated with the development of adult granulosa cell tumor...
March 27, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28320479/correlates-of-circulating-ovarian-cancer-early-detection-markers-and-their-contribution-to-discrimination-of-early-detection-models-results-from-the-epic-cohort
#19
Renée T Fortner, Allison F Vitonis, Helena Schock, Anika Hüsing, Theron Johnson, Raina N Fichorova, Titilayo Fashemi, Hidemi S Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Carlo La Vecchia, Domenico Palli, Sabina Sieri, Rosario Tumino, Giuseppe Matullo, Amalia Mattiello, N Charlotte Onland-Moret, Petra H Peeters, Elisabete Weiderpass, Inger Torhild Gram, Mie Jareid, J Ramón Quirós, Eric J Duell, Maria-Jose Sánchez, María Dolores Chirlaque, Eva Ardanaz, Nerea Larrañaga, Björn Nodin, Jenny Brändstedt, Annika Idahl, Kay-Tee Khaw, Naomi Allen, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A Merritt, Elio Riboli, Daniel W Cramer, Rudolf Kaaks, Kathryn L Terry
BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases)...
March 20, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28302175/prolonged-hypothyroidism-severely-reduces-ovarian-follicular-reserve-in-adult-rats
#20
Li Meng, Eddy Rijntjes, Hans J M Swarts, Jaap Keijer, Katja J Teerds
BACKGROUND: There is substantial evidence both in humans and in animals that a prolonged reduction in plasma thyroid hormone concentration leads to reproductive problems, including disturbed folliculogenesis, impaired ovulation and fertilization rates, miscarriage and pregnancy complications. The objective of the present study is to examine the consequences of chronic hypothyroidism, induced in adulthood, for the size of the ovarian follicle pool. In order to investigate this, adult female rats were provided either a control or an iodide deficient diet in combination with perchlorate supplementation to inhibit iodide uptake by the thyroid...
March 16, 2017: Journal of Ovarian Research
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