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Journal of Ovarian Research

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https://www.readbyqxmd.com/read/28814333/rapamycin-prevents-cyclophosphamide-induced-over-activation-of-primordial-follicle-pool-through-pi3k-akt-mtor-signaling-pathway-in-vivo
#1
Linyan Zhou, Yanqiu Xie, Song Li, Yihua Liang, Qi Qiu, Haiyan Lin, Qingxue Zhang
BACKGROUND: Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential mechanism for patients receiving chemotherapy. METHODS: 8-week old BALB/c female mice were randomly assigned into four groups (control; rapamycin; cyclophosphamide; and rapamycin combined with cyclophosphamide). Hematoxylin staining, immunohistochemical, TUNEL, western blotting and ELISA were employed to assess inter-group differences using Student's t-test and Mann-Whitney test...
August 16, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28806987/a-prospective-study-to-evaluate-the-risk-malignancy-index-and-its-diagnostic-implication-in-patients-with-suspected-ovarian-mass
#2
Santosh Kumar Dora, Atal Bihari Dandapat, Benudhar Pande, Jatindra Prasad Hota
BACKGROUND: There is no universal screening method for discrimination between benign and malignant adnexal masses yet. Various authors have tried tumor markers, imaging studies, cytology but no one yet is a definite method for screening of cancer ovary, for which a combined diagnostic modality has come to practice in form of RMI. With this background we conducted our study "Evaluation of risk malignancy index and its diagnostic value in patients with adnexal masses". METHODS: The aim of the study was to determine the effectiveness of risk of malignancy index (RMI-3) in preoperative discrimination between benign and malignant masses and also to reveal the most suitable cut off value...
August 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28789706/small-leucine-rich-proteoglycans-slrps-in-the-endometrium-of-polycystic-ovary-syndrome-women-a-pilot-study
#3
Ricardo Santos Simões, José Maria Soares-Jr, Manuel J Simões, Helena B Nader, Maria Cândida P Baracat, Gustavo Arantes R Maciel, Paulo C Serafini, Ricardo Azziz, Edmund C Baracat
BACKGROUND: Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the endometrium of polycystic ovary syndrome (PCOS) women is unknown. Our purpose was to test the hypothesis that excessive endometrial proliferation in PCOS may be partly related to abnormalities in SLRPs. METHODS: In a cross section study a total of 20 endometrial samples were collected from 10 patients with PCOS and 10 ovulatory women during their proliferative (pre-ovulatory) phase...
August 8, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28784174/early-and-consistent-overexpression-of-adrm1-in-ovarian-high-grade-serous-carcinoma
#4
Rosie T Jiang, Anna Yemelyanova, Deyin Xing, Ravi K Anchoori, Jun Hamazaki, Shigeo Murata, Jeffrey D Seidman, Tian-Li Wang, Richard B S Roden
BACKGROUND: Ovarian carcinoma is highly dependent on the ubiquitin proteasome system (UPS), but its clinical response to treatment with the proteasome inhibitor bortezomib has been disappointing. This has driven exploration of alternate approaches to target the UPS in ovarian cancer. Recently, proteasome inhibitors targeting the 19S regulatory particle-associated RPN13 protein have been described, such as RA190. RPN13, which is encoded by ADRM1, facilitates the recognition by the proteasome of its polyubiquinated substrates...
August 7, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28750644/a-retrospective-study-of-reproductive-outcomes-after-fertility-sparing-surgery-and-postoperative-adjuvant-chemotherapy-in-malignant-ovarian-germ-cell-tumors-and-sex-cord-stromal-tumors
#5
Ning Zhang, Ruifang Chen, Keqin Hua, Ying Zhang
BACKGROUND: To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST). METHODS: Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed...
July 27, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28743298/r-spondin2-a-novel-target-of-nobox-identification-of-variants-in-a-cohort-of-women-with-primary-ovarian-insufficiency
#6
Justine Bouilly, Isabelle Beau, Sara Barraud, Valérie Bernard, Brigitte Delemer, Jacques Young, Nadine Binart
BACKGROUND: R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle development. Rspo2 heterozygous deficient female mice become infertile around 4 months of age mimicking primary ovarian insufficiency (POI). The study aimed to investigate the regulation of RSPO2 and its potential involvement in pathophysiology of POI. METHODS: We cloned the RSPO2 promoter and performed transcriptional assays to determine if RSPO2 can be regulated by NOBOX, an ovarian transcription factor...
July 25, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28743276/suppressing-mir-199a-3p-by-promoter-methylation-contributes-to-tumor-aggressiveness-and-cisplatin-resistance-of-ovarian-cancer-through-promoting-ddr1-expression
#7
Yuao Deng, Fang Zhao, Liu Hui, Xiuyun Li, Danyu Zhang, Wang Lin, Zhiqiang Chen, Yingxia Ning
BACKGROUND: Discoidin Domain Receptor 1 (DDR1) belongs to the family of collagen receptor tyrosine kinases that confers the progression of various cancers. Aberrant expression of DDR1 was detected in several human cancers including ovarian cancer, which had been shown to increase the migration and invasion of tumor cells. However, the precise mechanisms underlying the abnormal expression of DDR1 in ovarian cancer has not been well investigated in previous studies. RESULTS: In this work, a negative correlation between DDR1 and a tumor suppressor miRNA, miR-199a-3p, was observed in ovarian cancer tissues...
July 25, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28738876/enterolactone-has-stronger-effects-than-enterodiol-on-ovarian-cancer
#8
Huidi Liu, Jianrui Liu, Siwen Wang, Zheng Zeng, Ting Li, Yongfang Liu, Emilio Mastriani, Qing-Hai Li, Hong-Xia Bao, Yu-Jie Zhou, Xiaoyu Wang, Sijing Hu, Shan Gao, Yingying Qi, Zhihang Shen, Hongyue Wang, Miao Yu, Tingting Gao, Randal N Johnston, Shu-Lin Liu
BACKGROUND: Ovarian cancer is one of the three leading gynecological malignancies, characterized by insidious growth, highly frequent metastasis, and quick development of drug resistance. As a result, this disease has low 5-year survival rates. Estrogen receptor inhibitors were commonly used for the treatment, but only 7% to 18% of patients respond to anti-estrogen therapies. Therefore, more effective therapies to inhibit estrogen-related tumors are urgently needed. Recently, phytoestrogens, such as lignans with estrogen-like biological activities, have attracted attention for their potential effects in the prevention or treatment of estrogen-related diseases...
July 24, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28738842/ovarian-preservation-in-adenocarcinoma-of-the-uterine-cervix
#9
Jiansong Zhou, Yuanyuan Chen, Ping Zhang, Hanmei Lou
BACKGROUND: An upward trending incidence in cervical adenocarcinoma (ADC) has been reported in many countries. Because non-squamous histology has been associated with increased risk of ovarian metastases (OM), bilateral oophorectomy is commonly performed for ADC without due consideration for ovarian preservation, degrading the quality of life for young premenopausal patients. METHODS: Subjects were patients with International Federation of Gynecology and Obstetrics (FIGO) stage I-IIB cervical ADC who underwent radical hysterectomy, including pelvic lymphadenectomy and bilateral salpingo-oophorectomy at our institution between Oct...
July 24, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28728581/a-gestational-choriocarcinoma-of-the-ovary-diagnosed-by-dna-polymorphic-analysis-a-case-report-and-systematic-review-of-the-literature
#10
Nan Jia, Yan Chen, Xiang Tao, Enzhi Ou, Xin Lu, Weiwei Feng
BACKGROUND: Choriocarcinoma of the ovary is rare. This tumor can arise from gestational tissue or pure germ cells of the ovary, the former results in gestational choriocarcinoma. The clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to identify the presence of paternal DNA by DNA polymorphic analysis. CASE PRESENTATION: In the present case, a 27-year-old patient with a history of amenorrhea, lower abdominal pain and vaginal bleeding received a laparoscopic dissection of cystic mass of the right ovary according to an initial diagnosis of ectopic pregnancy...
July 20, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28728562/low-oxygen-tension-increases-mitochondrial-membrane-potential-and-enhances-expression-of-antioxidant-genes-and-implantation-protein-of-mouse-blastocyst-cultured-in-vitro
#11
Yun-Yi Ma, Huei-Wen Chen, Chii-Ruey Tzeng
BACKGROUND: In human IVF, embryos cultured with a lower O2 tension (5%) can give rise to higher success rates when compared with normoxic conditions (20%). However, the mechanisms behind the beneficial effects of reduced oxygen tension in embryogenesis remain unclear. The aim of this study was to evaluate the expression of oxygen related and antioxidant genes and mitochondrial function in mouse embryo cultured under hypoxic and normoxic conditions, to investigate the beneficial effect of low oxygen tension in preimplantation embryogenesis...
July 20, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28716151/predictive-factors-of-ovarian-carcinoma-for-women-with-ovarian-endometrioma-aged-45%C3%A2-years-and-older-in-china
#12
Zheng-Xing He, Hong-Hui Shi, Qing-Bo Fan, Lan Zhu, Jin-Hua Leng, Da-Wei Sun, Zhan-Fei Li, Keng Shen, Shu Wang, Jing-He Lang
BACKGROUND: To explore the risk factors of endometriosis-associated ovarian cancer (EAOC) in women with ovarian endometriosis (OEM) aged 45 years and above in China. METHODS: This study reviewed the medical records of 1038 women in total who were aged 45 years and above, surgical-pathologically diagnosed with ovarian endometriosis, and were treated at Peking Union Medical College Hospital between December 1996 and December 2016. Histology evaluation was used to determine whether the ovarian endometriosis specimen was with (n = 30) or without (n = 1008) ovarian cancer...
July 17, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28701212/is-the-oocyte-quality-affected-by-endometriosis-a-review-of-the-literature
#13
REVIEW
Ana Maria Sanchez, Valeria Stella Vanni, Ludovica Bartiromo, Enrico Papaleo, Eran Zilberberg, Massimo Candiani, Raoul Orvieto, Paola Viganò
Endometriosis is an estrogen-dependent chronic inflammatory condition that affects women in their reproductive period causing infertility and pelvic pain. The disease, especially at the ovarian site has been shown to have a detrimental impact on ovarian physiology. Indeed, sonographic and histologic data tend to support the idea that ovarian follicles of endometriosis patients are decreased in number and more atretic. Moreover, the local intrafollicular environment of patients affected is characterized by alterations of the granulosa cell compartment including reduced P450 aromatase expression and increased intracellular reactive oxygen species generation...
July 12, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28701210/follicular-fluid-redox-involvement-for-ovarian-follicle-growth
#14
REVIEW
Cláudia Freitas, Ana Catarina Neto, Liliana Matos, Elisabete Silva, Ângela Ribeiro, João Luís Silva-Carvalho, Henrique Almeida
As the human ovarian follicle enlarges in the course of a regular cycle or following controlled ovarian stimulation, the changes in its structure reveal the oocyte environment composed of cumulus oophorus cells and the follicular fluid (FF).In contrast to the dynamic nature of cells, the fluid compartment appears as a reservoir rich in biomolecules. In some aspects, it is similar to the plasma, but it also exhibits differences that likely relate to its specific localization around the oocyte. The chemical composition indicates that the follicular fluid is able to detect and buffer excessive amounts of reactive oxygen species, employing a variety of antioxidants, some of them components of the intracellular milieu...
July 12, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28693528/impact-of-oocytes-with-clcg-on-icsi-outcomes-and-their-potential-relation-to-pesticide-exposure
#15
Philippe Merviel, Rosalie Cabry, Karen Chardon, Elodie Haraux, Florence Scheffler, Naima-Belhadri Mansouri, Aviva Devaux, Hikmat Chahine, Véronique Bach, Henri Copin, Moncef Benkhalifa
BACKGROUND: Oocyte quality is a key limiting factor in female fertility which is primarily reflected in morphological features. Centrally located cytoplasm granulation (CLCG) is one type of cytoplasmic dimorphism exhibited by oocytes that could be linked to pesticide exposure with a significant risk of decreased ICSI outcomes. METHODS: This retrospective study included 633 women who were part of an intracytoplasmic spermatozoa injection (ICSI) program between 2009 and 2011...
July 10, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28683759/intravenous-neutralization-of-vascular-endothelial-growth-factor-reduces-vascular-function-permeability-of-the-ovary-and-prevents-development-of-ohss-like-symptoms-in-rhesus-monkeys
#16
C V Bishop, D M Lee, O D Slayden, X Li
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is a disorder associated with elevated serum VEGFA following chorionic gonadotropin (hCG) exposure in controlled ovarian stimulation (COS) cycles in women. In this study, we tested the effect of intravenous VEGFA neutralization on OHSS-like symptoms and vascular function in rhesus macaques during COS cycles. METHODS: Monkeys (n = 8) were treated with 3 COS protocols and assigned randomly to groups as follows: 1) COS alone (Control, n = 5); 2) COS + VEGF mAb Avastin 19 ± 5 h before hCG (Avastin pre-hCG; n = 6); 3) COS + Avastin 3-4 days post-hCG (Avastin post-hCG; n = 4); 4) COS + Simulated Early Pregnancy (SEP n = 3); or 5) COS + SEP + Avastin (SEP + Avastin n = 3)...
July 6, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28679402/wap-four-disulfide-core-domain-protein-2-promotes-metastasis-of-human-ovarian-cancer-by-regulation-of-metastasis-associated-genes
#17
Yao Chen, Liping Huang, Suihai Wang, Tiancai Liu, Yingsong Wu, Ji-Liang Li, Ming Li
BACKGROUND: WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. METHODS: In this study, we evaluated the role of WFCD2 in tumor mobility, invasion and metastasis of ovarian cancer in clinical tissue and in ovarian cancer cells, both in vitro and in vivo. RESULTS: Our results revealed WFCD2 was overexpressed in ovarian tissues, and the expression level of WFCD2 was associated with metastasis and lymph node metastasis...
July 5, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28662671/plasma-levels-of-mmp-7-and-timp-1-in-laboratory-diagnostics-and-differentiation-of-selected-histological-types-of-epithelial-ovarian-cancers
#18
Grażyna Ewa Będkowska, Ewa Gacuta, Monika Zajkowska, Edyta Katarzyna Głażewska, Joanna Osada, Maciej Szmitkowski, Lech Chrostek, Milena Dąbrowska, Sławomir Ławicki
BACKGROUND: MMP-7 and TIMP-1 may play a role in the pathogenesis of cancer disease. In this study we investigated plasma levels of selected metalloproteinase and its tissue inhibitor in comparison to plasma levels of the commonly accepted tumor markers (CA 125 and HE4) in selected histological types of epithelial ovarian cancer patients as compared to control groups: patients with a benign ovarian tumor and healthy subjects. Plasma levels of MMP-7 and TIMP-1 were determined using ELISA, CA 125 and HE4 - by CMIA methods...
June 29, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28645304/validation-of-an-automated-technique-for-ovarian-cortex-dissociation-isolation-of-viable-ovarian-cells-and-their-qualification-by-multicolor-flow-cytometry
#19
Tristan Zver, Elodie Mouloungui, Aurélie Berdin, Christophe Roux, Clotilde Amiot
BACKGROUND: Ovarian tissue cryopreservation is a technique for fertility preservation addressed to prepubertal girls or to patients for whom no ovarian stimulation is possible before initiation of gonadotoxic treatments. Autotransplantation of frozen-thawed ovarian tissue is the only available option for reuse but presents some limitations: ischemic tissue damages post-transplant and reintroduction of malignant cells in cases of cancer. It is therefore essential to qualify ovarian tissue before autograft on a functional and oncological point of view...
June 23, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28629378/microrna-130b-is-involved-in-bovine-granulosa-and-cumulus-cells-function-oocyte-maturation-and-blastocyst-formation
#20
Pritam Bala Sinha, Dawit Tesfaye, Franca Rings, Munir Hossien, Michael Hoelker, Eva Held, Christaine Neuhoff, Ernst Tholen, Karl Schellander, Dessie Salilew-Wondim
BACKGROUND: Oocyte maturation and preimplantation embryo development are controlled by array of genes that are post-transcriptionally regulated by microRNAs. With respect to this, previously, we identified altered expression of microRNA-130b (miR-130b) during oocyte maturation. Here, we aimed to investigate the role of miR-130b in bovine granulosa and cumulus cell function, oocyte maturation and preimplantation embryo development using gain- and loss-of- function approach. METHODS: For this study, the granulosa cells, cumulus cells and the oocytes were collected from ovaries obtained from slaughterhouse...
June 19, 2017: Journal of Ovarian Research
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