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Circulation. Arrhythmia and Electrophysiology

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https://www.readbyqxmd.com/read/28630176/diagnostic-perturbations
#1
REVIEW
Samuel J Asirvatham, William G Stevenson
No abstract text is available yet for this article.
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630175/patient-specific-induced-pluripotent-stem-cell-based-disease-model-for-pathogenesis-studies-and-clinical-pharmacotherapy
#2
EDITORIAL
Yingxin Li, Karim Sallam, Peter J Schwartz, Joseph C Wu
No abstract text is available yet for this article.
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630174/experimental-pathologic-and-clinical-findings-of-radiofrequency-catheter-ablation-of-para-hisian-region-from-the-right-ventricle-in-dogs-and-humans
#3
Yumei Xue, Xianzhang Zhan, Shulin Wu, Hongyue Wang, Yang Liu, Zili Liao, Hai Deng, Xuejing Duan, Shaoying Zeng, Dongpo Liang, Arif Elvan, Xianhong Fang, Hongtao Liao, Anand R Ramdat Misier, Jaap Jan J Smit, Andreas Metzner, Christian-Hendrik Heeger, Fangzhou Liu, Feng Wang, Zhiwei Zhang, Karl-Heinz Kuck, Siew Yen Ho, Feifan Ouyang
BACKGROUND: Ablation of para-Hisian accessory pathway (AP) poses high risks of atrioventricular block. We developed a pacing technique to differentiate the near-field (NF) from far-field His activations to avoid the complication. METHODS AND RESULTS: Three-dimensional mapping of the right ventricle was performed in 15 mongrel dogs and 23 patients with para-Hisian AP. Using different pacing outputs, the NF- and far-field His activation was identified on the ventricular aspect...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630173/primary-prevention-of-sudden-cardiac-death-early-post-myocardial-infarction-root-cause-analysis-for-implantable-cardioverter-defibrillator-failure-and-currently-available-options
#4
REVIEW
Claude S Elayi, Richard J Charnigo, Paula M Heron, Byron K Lee, Jeffrey E Olgin
No abstract text is available yet for this article.
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630172/role-of-his-refractory-premature-ventricular-complexes-in-the-differential-diagnosis-of-a-left-bundle-branch-block-morphology-tachycardia
#5
REVIEW
Shiv Bagga, Parin J Patel, Eric N Prystowsky, Benzy J Padanilam
No abstract text is available yet for this article.
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630171/distinctive-left-ventricular-activations-associated-with-ecg-pattern-in-heart-failure-patients
#6
Nicolas Derval, Josselin Duchateau, Saagar Mahida, Romain Eschalier, Frederic Sacher, Joost Lumens, Hubert Cochet, Arnaud Denis, Xavier Pillois, Seigo Yamashita, Yuki Komatsu, Sylvain Ploux, Sana Amraoui, Adlane Zemmoura, Philippe Ritter, Mélèze Hocini, Michel Haissaguerre, Pierre Jaïs, Pierre Bordachar
BACKGROUND: In contrast to patients with left bundle branch block (LBBB), heart failure patients with narrow QRS and nonspecific intraventricular conduction delay (NICD) display a relatively limited response to cardiac resynchronization therapy. We sought to compare left ventricular (LV) activation patterns in heart failure patients with narrow QRS and NICD to patients with LBBB using high-density electroanatomic activation maps. METHODS AND RESULTS: Fifty-two heart failure patients (narrow QRS [n=18], LBBB [n=11], NICD [n=23]) underwent 3-dimensional electroanatomic mapping with a high density of mapping points (387±349 LV)...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630170/characterization-of-aortic-valve-closure-artifact-during-outflow-tract-mapping-correlation-with-hemodynamics-and-mechanical-valves
#7
Jorge Romero, Olujimi Ajijola, Kalyanam Shivkumar, Roderick Tung
BACKGROUND: Premature ventricular contractions originating in the left ventricle outflow tract represent a significant subgroup of patients referred for catheter ablation. Mechanical artifacts from aortic valve leaflet motion may be observed during mapping, although the incidence and characteristics have not been reported. METHODS AND RESULTS: Twenty-eight consecutive patients with left ventricle outflow tract premature ventricular contraction were included. Electric signals recorded on the ablation catheter not coincident with atrial or ventricular depolarization were analyzed on the recording system...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630169/patient-specific-drug-screening-using-a-human-induced-pluripotent-stem-cell-model-of-catecholaminergic-polymorphic-ventricular-tachycardia-type-2
#8
Leonid Maizels, Irit Huber, Gil Arbel, Anke J Tijsen, Amira Gepstein, Asaad Khoury, Lior Gepstein
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) results from autosomal recessive CASQ2 mutations, causing abnormal Ca(2+)-handling and malignant ventricular arrhythmias. We aimed to establish a patient-specific human induced pluripotent stem cell (hiPSC) model of CPVT2 and to use the generated hiPSC-derived cardiomyocytes to gain insights into patient-specific disease mechanism and pharmacotherapy. METHODS AND RESULTS: hiPSC cardiomyocytes were derived from a CPVT2 patient (D307H-CASQ2 mutation) and from healthy controls...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630168/incidence-and-factors-associated-with-the-occurrence-of-pulmonary-vein-narrowing-after-cryoballoon-ablation
#9
Ryohsuke Narui, Michifumi Tokuda, Masato Matsushima, Ryota Isogai, Kenichi Tokutake, Kenichi Yokoyama, Mika Hioki, Keiichi Ito, Shin-Ichi Tanigawa, Seigo Yamashita, Keiichi Inada, Kenri Shibayama, Seiichiro Matsuo, Satoru Miyanaga, Kenichi Sugimoto, Michihiro Yoshimura, Teiichi Yamane
BACKGROUND: In contrast with traditional radiofrequency ablation, little is known about the influence of cryoballoon ablation on the morphology of pulmonary veins (PVs). We evaluated the influence of cryoballoon ablation on the PV dimension (PVD) and investigated the factors associated with a reduction of the PVD. METHODS AND RESULTS: Seventy-four patients who underwent cryoballoon ablation for paroxysmal atrial fibrillation were included in the present study. All subjects underwent contrast-enhanced computed tomography both before and at 3 months after the procedure...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28611208/modifying-arrhythmia-behavior-preablation-with-drug-therapy-may-improve-single-procedure-efficacy-of-a-limited-ablation-strategy-in-patients-with-persistent-atrial-fibrillation
#10
EDITORIAL
Sanjay Dixit, Jackson J Liang, Rajeev K Pathak
No abstract text is available yet for this article.
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28611207/adult-ventricular-myocytes-segregate-kcnq1-and-kcne1-to-keep-the-iks-amplitude-in-check-until-when-larger-iks-is-needed
#11
Min Jiang, Yuhong Wang, Gea-Ny Tseng
BACKGROUND: KCNQ1 and KCNE1 assemble to form the slow delayed rectifier (IKs) channel critical for shortening ventricular action potentials during high β-adrenergic tone. However, too much IKs under basal conditions poses an arrhythmogenic risk. Our objective is to understand how adult ventricular myocytes regulate the IKs amplitudes under basal conditions and in response to stress. METHODS AND RESULTS: We express fluorescently tagged KCNQ1 and KCNE1 in adult ventricular myocytes and follow their biogenesis and trafficking paths...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28611206/pulmonary-vein-isolation-alone-versus-additional-linear-ablation-in-patients-with-persistent-atrial-fibrillation-converted-to-paroxysmal-type-with-antiarrhythmic-drug-therapy-a-multicenter-prospective-randomized-study
#12
Hee Tae Yu, Jaemin Shim, Junbeom Park, In-Soo Kim, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Young-Hoon Kim, Hui-Nam Pak
BACKGROUND: Atrial fibrillation (AF) type can vary depending on condition and timing, and some patients who initially present with persistent AF may be changed to paroxysmal AF after antiarrhythmic drug medication and cardioversion. We investigated whether circumferential pulmonary vein isolation (CPVI) alone is an effective rhythm control strategy in patients with persistent AF to paroxysmal AF. METHODS AND RESULTS: We enrolled 113 patients with persistent AF to paroxysmal AF (male 75%, 60...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28588014/different-approaches-for-catheter-ablation-of-para-hisian-accessory-pathways-implications-for-mapping-and-ablation
#13
Ming Liang, Zulu Wang, Yanchun Liang, Guitang Yang, Zhiqing Jin, Mingyu Sun, Yaling Han
BACKGROUND: Catheter ablation of para-Hisian accessory pathways (APs) can be challenging because of adjacent conduction tissue. Some different approaches for ablation, including the inferior vena cava approach (IVC-A), the noncoronary cusp approach (NCC-A), or the superior vena cava approach (SVC-A), have been reported. However, when should para-Hisian APs be mapped and ablated by the IVC-A, NCC-A, or SVC-A is not well established. METHODS AND RESULTS: This study included 55 consecutive patients (mean age, 53±11 years, 36 males) with para-Hisian APs...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28576781/electrocardiographic-preexcitation-and-risk-of-cardiovascular-morbidity-and-mortality-results-from-the-copenhagen-ecg-study
#14
Morten W Skov, Peter V Rasmussen, Jonas Ghouse, Steen M Hansen, Claus Graff, Morten S Olesen, Adrian Pietersen, Christian Torp-Pedersen, Stig Haunsø, Lars Køber, Jesper H Svendsen, Anders G Holst, Jonas B Nielsen
BACKGROUND: The majority of available data on the clinical course of patients with ventricular preexcitation in the ECG originates from tertiary centers. We aimed to investigate long-term outcomes in individuals from a primary care population with electrocardiographic preexcitation. METHODS AND RESULTS: Digital ECGs from 328 638 primary care patients were collected during 2001 to 2011. We identified 310 individuals with preexcitation (age range, 8-85 years). Data on medication, comorbidity, and outcomes were collected from Danish nationwide registries...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28576780/outcomes-of-ventricular-tachycardia-ablation-using-percutaneous-left-ventricular-assist-devices
#15
Shigeki Kusa, Marc A Miller, William Whang, Yoshinari Enomoto, Jorge G Panizo, Jin Iwasawa, Subbarao Choudry, Sean Pinney, Anthony Gomes, Noelle Langan, Jacob S Koruth, Andre d'Avila, Vivek Y Reddy, Srinivas R Dukkipati
BACKGROUND: Although percutaneous left ventricular assist devices (pLVADs) facilitate mapping and ablation of hemodynamically unstable ventricular tachycardia (VT), there is limited data whether clinical outcomes are improved. We sought to retrospectively compare the outcomes of patients undergoing scar-related VT ablation with and without pLVAD support. METHODS AND RESULTS: The study population comprised 194 patients (109 pLVAD and 85 non-pLVAD). The pLVAD group more often had dilated cardiomyopathy (33% versus 13%; P=0...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500180/induced-pluripotent-stem-cell-based-treatment-of-acquired-heart-block-the-battle-for-tomorrow-has-begun
#16
EDITORIAL
Wenbin Liang, Aizhu Lu, Darryl R Davis
No abstract text is available yet for this article.
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500179/is-tgf-%C3%AE-1-transforming-growth-factor-%C3%AE-1-an-enabler-of-myofibroblast-cardiomyocyte-cross-talk
#17
EDITORIAL
Kuljeet Kaur, José Jalife
No abstract text is available yet for this article.
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500178/electrical-substrate-elimination-in-135-consecutive-patients-with-brugada-syndrome
#18
Carlo Pappone, Josep Brugada, Gabriele Vicedomini, Giuseppe Ciconte, Francesco Manguso, Massimo Saviano, Raffaele Vitale, Amarild Cuko, Luigi Giannelli, Zarko Calovic, Manuel Conti, Paolo Pozzi, Andrea Natalizia, Simonetta Crisà, Valeria Borrelli, Ramon Brugada, Georgia Sarquella-Brugada, Marco Guazzi, Alessandro Frigiola, Lorenzo Menicanti, Vincenzo Santinelli
BACKGROUND: There is emerging evidence that localization and elimination of abnormal electric activity in the epicardial right ventricular outflow tract may be beneficial in patients with Brugada syndrome. METHODS AND RESULTS: A total of 135 symptomatic Brugada syndrome patients having implantable cardiac defibrillator were enrolled: 63 (group 1) having documented ventricular tachycardia (VT)/ventricular fibrillation (VF) and Brugada syndrome-related symptoms, and 72 (group 2) having inducible VT/VF without ECG documentation at the time of symptoms...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500177/efficacy-of-an-anatomical-approach-in-radiofrequency-catheter-ablation-of-idiopathic-ventricular-arrhythmias-originating-from-the-left-ventricular-outflow-tract
#19
Takumi Yamada, Naoki Yoshida, Harish Doppalapudi, Silvio H Litovsky, H Thomas McElderry, G Neal Kay
BACKGROUND: When anatomic obstacles preclude radiofrequency catheter ablation of idiopathic ventricular arrhythmias (VAs) originating from the left ventricular outflow tract (LVOT), an alternative approach from the anatomically opposite side (endocardial versus epicardial or above versus below the aortic valve) may be considered (anatomic ablation). The purpose of this study was to investigate the efficacy of an anatomic ablation in idiopathic LVOT VAs. METHODS AND RESULTS: We studied 229 consecutive patients with idiopathic LVOT VAs...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500176/mitral-aortic-flow-reversal-in-cardiac-resynchronization-therapy-coupling-with-ejection-and-impact-of-variations-in-atrioventricular-delay
#20
Daniel Rodríguez Muñoz, José Luis Moya Mur, Javier Moreno, Covadonga Fernández-Golfín, Eduardo Franco, Bostjan Berlot, Juan Manuel Monteagudo, Roberto Matía Francés, Antonio Hernández Madrid, José Luis Zamorano
BACKGROUND: Flow entering the left ventricle is reversed toward the outflow tract through rotating reversal flow around the mitral valve. This was thought to facilitate early ejection, but had not been proved to date. We hypothesized that perfect coupling between reversal and ejection flow would occur at optimal atrioventricular delay (AVD), contributing to its hemodynamic superiority, and evaluated its applicability for AVD optimization. METHODS AND RESULTS: Forty consecutive patients with cardiac resynchronization therapy underwent intracardiac flow analysis and AVD optimization...
May 2017: Circulation. Arrhythmia and Electrophysiology
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