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Circulation. Arrhythmia and Electrophysiology

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https://www.readbyqxmd.com/read/28213509/ventricular-microanatomy-arrhythmias-and-the-electrochemical-driving-force-for-na-is-there-a-need-for-flipped-learning
#1
EDITORIAL
Luiz Belardinelli, Mary M Maleckar, Wayne R Giles
No abstract text is available yet for this article.
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28213508/familial-occurrence-of-atrioventricular-nodal-reentrant-tachycardia
#2
Yoav Michowitz, Adi Anis-Heusler, Eyal Reinstein, Oholi Tovia-Brodie, Aharon Glick, Bernard Belhassen
BACKGROUND: Atrioventricular nodal reentrant tachycardia (AVNRT) is considered a sporadic disease occurring in ≈22.5 cases per 10 000 in the general population. We define the prevalence and characteristics of familial AVNRT among patients who underwent radiofrequency ablation. METHODS AND RESULTS: Ablation reports of all patients with familial AVNRT (at least 2 first-degree family members) who underwent radiofrequency ablation in our institution and in another hospital were reviewed...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28213507/effect-of-sleep-disordered-breathing-on-appropriate-implantable-cardioverter-defibrillator-therapy-in-patients-with-heart-failure-a-systematic-review-and-meta-analysis
#3
Younghoon Kwon, Ryan J Koene, Osung Kwon, Jessica V Kealhofer, Selcuk Adabag, Sue Duval
BACKGROUND: Patients with heart failure and reduced ejection fraction are at increased risk of malignant ventricular arrhythmias. Implantable cardioverter-defibrillator (ICD) is recommended to prevent sudden cardiac death in some of these patients. Sleep-disordered breathing (SDB) is highly prevalent in this population and may impact arrhythmogenicity. We performed a systematic review and meta-analysis of prospective studies that assessed the impact of SDB on ICD therapy. METHODS AND RESULTS: Relevant prospective studies were identified in the Ovid MEDLINE, EMBASE, and Google Scholar databases...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28213506/role-of-apamin-sensitive-calcium-activated-small-conductance-potassium-currents-on-the-mechanisms-of-ventricular-fibrillation-in-pacing-induced-failing-rabbit-hearts
#4
Dechun Yin, Yu-Cheng Hsieh, Wei-Chung Tsai, Adonis Zhi-Yang Wu, Zhaolei Jiang, Yi-Hsin Chan, Dongzhu Xu, Na Yang, Changyu Shen, Zhenhui Chen, Shien-Fong Lin, Peng-Sheng Chen, Thomas H Everett
BACKGROUND: Ventricular fibrillation (VF) during heart failure is characterized by stable reentrant spiral waves (rotors). Apamin-sensitive small-conductance calcium-activated potassium currents (IKAS) are heterogeneously upregulated in failing hearts. We hypothesized that IKAS influences the location and stability of rotors during VF. METHODS AND RESULTS: Optical mapping was performed on 9 rabbit hearts with pacing-induced heart failure. The epicardial right ventricular and left ventricular surfaces were simultaneously mapped in a Langendorff preparation...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28213505/revealing-the-concealed-nature-of-long-qt-type-3-syndrome
#5
Amara Greer-Short, Sharon A George, Steven Poelzing, Seth H Weinberg
BACKGROUND: Gain-of-function mutations in the voltage-gated sodium channel (Nav1.5) are associated with the long-QT-3 (LQT3) syndrome. Nav1.5 is densely expressed at the intercalated disk, and narrow intercellular separation can modulate cell-to-cell coupling via extracellular electric fields and depletion of local sodium ion nanodomains. Models predict that significantly decreasing intercellular cleft widths slows conduction because of reduced sodium current driving force, termed "self-attenuation...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28213504/adjunctive-interventional-techniques-when-percutaneous-catheter-ablation-for-drug-refractory-ventricular-arrhythmias-fail-a-contemporary-review
#6
Saurabh Kumar, Usha B Tedrow, William G Stevenson
No abstract text is available yet for this article.
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28202632/selective-modulation-of-the-cardiac-autonomic-nervous-system-a-new-strategy-for-treatment-of-cardiohibitory-syncope
#7
EDITORIAL
Siva K Mulpuru, Win-Kuang Shen
No abstract text is available yet for this article.
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28202631/cardiac-resynchronization-therapy-upgrade-verschlimmbesserung
#8
EDITORIAL
Anoop K Shetty, Christopher A Rinaldi
No abstract text is available yet for this article.
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28202630/targets-and-end-points-in-cardiac-autonomic-denervation-procedures
#9
Esteban W Rivarola, Denise Hachul, Tan Wu, Cristiano Pisani, Carina Hardy, Fabrizio Raimundi, Sissy Melo, Francisco Darrieux, Mauricio Scanavacca
BACKGROUND: Autonomic denervation is an alternative approach for patients with symptomatic bradycardia. No consensus exists on the critical targets and end points of the procedure. The aim of this study was to identify immediate end points and critical atrial regions responsible for vagal denervation. METHODS AND RESULTS: We enrolled 14 patients (50% men; age: 34.0±13.8 years) with cardioinhibitory syncope, advanced atrioventricular block or sinus arrest, and no structural heart disease...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28202629/improving-the-in-silico-assessment-of-proarrhythmia-risk-by-combining-herg-human-ether-%C3%A3-go-go-related-gene-channel-drug-binding-kinetics-and-multichannel-pharmacology
#10
Zhihua Li, Sara Dutta, Jiansong Sheng, Phu N Tran, Wendy Wu, Kelly Chang, Thembi Mdluli, David G Strauss, Thomas Colatsky
BACKGROUND: The current proarrhythmia safety testing paradigm, although highly efficient in preventing new torsadogenic drugs from entering the market, has important limitations that can restrict the development and use of valuable new therapeutics. The CiPA (Comprehensive in vitro Proarrhythmia Assay) proposes to overcome these limitations by evaluating drug effects on multiple cardiac ion channels in vitro and using these data in a predictive in silico model of the adult human ventricular myocyte...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28202628/effects-of-upgrade-versus-de-novo-cardiac-resynchronization-therapy-on-clinical-response-and-long-term-survival-results-from-a-multicenter-study
#11
Mate Vamos, Julia W Erath, Zsolt Bari, Denes Vagany, Sven P Linzbach, Tatsiana Burmistrava, Carsten W Israel, Gabor Z Duray, Stefan H Hohnloser
BACKGROUND: Benefits of cardiac resynchronization therapy (CRT) on morbidity and mortality in selected patients are well known. Although the number of upgrade procedures from single- or dual-chamber devices to CRT is increasing, there are only sparse data on the outcomes of upgrade procedures compared with de novo CRT. This study aimed to evaluate clinical response and survival in patients receiving de novo versus upgrade CRT defibrillator therapy. METHODS AND RESULTS: Prospectively collected outcome data were compared in patients undergoing de novo or upgrade CRT defibrillator implantation at 3 implant centers in Germany and Hungary...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28183845/incidence-of-idiopathic-ventricular-arrhythmias-a-population-based-study
#12
Surksha Sirichand, Ammar M Killu, Deepak Padmanabhan, David O Hodge, Alanna M Chamberlain, Peter A Brady, Suraj Kapa, Peter A Noseworthy, Douglas L Packer, Thomas M Munger, Bernard J Gersh, Christopher J McLeod, Win-Kuang Shen, Yong-Mei Cha, Samuel J Asirvatham, Paul A Friedman, Siva K Mulpuru
BACKGROUND: Ventricular tachycardia and premature ventricular complexes (PVCs) most frequently occur in the context of structural heart disease. However, the burden of idiopathic ventricular arrhythmias (IVA) in the general population is unknown. METHODS AND RESULTS: We identified incident cases of IVA between 2005 and 2013 from Olmsted County, Minnesota, using the Rochester Epidemiology Project database. For PVC cohorts, we included those with frequent (defined as ≥100 PVC/24 hours) symptomatic PVCs...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28183844/association-between-posterior-left-atrial-adipose-tissue-mass-and-atrial-fibrillation
#13
Alexander R van Rosendael, Aukelien C Dimitriu-Leen, Philippe J van Rosendael, Melissa Leung, Jeff M Smit, Antti Saraste, Juhani Knuuti, Rob J van der Geest, Britt W H van der Arend, Erik W van Zwet, Arthur J Scholte, Victoria Delgado, Jeroen J Bax
BACKGROUND: Epicardial adipose tissue located close to the atrial wall can change the electric conduction of the left atrium, potentially leading to atrial fibrillation (AF). The aim of this study was to assess whether an increased atrial adipose tissue mass posterior to the left atrium is related to AF independent of demographical and cardiovascular risk factors. METHODS AND RESULTS: Two hundred patients with AF and 200 patients without AF who underwent computed tomographic angiography were included...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28183843/left-atrial-size-and-function-in-hypertrophic-cardiomyopathy-patients-and-risk-of-new-onset-atrial-fibrillation
#14
Philippe Debonnaire, Emer Joyce, Yasmine Hiemstra, Bart J Mertens, Douwe E Atsma, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
BACKGROUND: The value of left atrial (LA) diameter, volume, and strain to risk stratify hypertrophic cardiomyopathy patients for new-onset atrial fibrillation (AF) was explored. METHODS AND RESULTS: A total of 242 hypertrophic cardiomyopathy patients without AF history were evaluated by (speckle-tracking) echocardiography. During mean follow-up of 4.8±3.7 years, 41 patients (17%) developed new-onset AF. Multivariable analysis showed LA volume (≥37 mL/m(2); hazard ratio, 2...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28148547/electrophysiological-twisting-electrical-alternans-in-congenital-dilated-cardiomyopathy
#15
Rimsha Arif, Arif Hussain, Santokh Dhillon
No abstract text is available yet for this article.
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28148546/correction-to-association-of-rate-dependent-conduction-block-between-eccentric-coronary-sinus-to-left-atrial-connections-with-inducible-atrial-fibrillation-and-flutter
#16
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28087564/right-ventricular-ejection-fraction-is-incremental-to-left-ventricular-ejection-fraction-for-the-prediction-of-future-arrhythmic-events-in-patients-with-systolic-dysfunction
#17
Yoko Mikami, Umjeet Jolly, Bobak Heydari, Mingkai Peng, Fahad Almehmadi, Mohammed Zahrani, Mahmoud Bokhari, John Stirrat, Carmen P Lydell, Andrew G Howarth, Raymond Yee, James A White
BACKGROUND: Left ventricular ejection fraction remains the primary risk stratification tool used in the selection of patients for implantable cardioverter defibrillator therapy. However, this solitary marker fails to identify a substantial portion of patients experiencing sudden cardiac arrest. In this study, we examined the incremental value of considering right ventricular ejection fraction for the prediction of future arrhythmic events in patients with systolic dysfunction using the gold standard of cardiovascular magnetic resonance...
January 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28087563/fascicular-ventricular-arrhythmias-pathophysiologic-mechanisms-anatomical-constructs-and-advances-in-approaches-to-management
#18
Suraj Kapa, Prakriti Gaba, Christopher V DeSimone, Samuel J Asirvatham
No abstract text is available yet for this article.
January 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28082528/right-ventricular-structure-and-function-are-associated-with-incident-atrial-fibrillation-mesa-rv-study-multi-ethnic-study-of-atherosclerosis-right-ventricle
#19
Neal A Chatterjee, Ravi V Shah, Venkatesh L Murthy, Amy Praestgaard, Sanjiv J Shah, Corey E Ventetuolo, R Graham Barr, Richard Kronmal, Joao A C Lima, David A Bluemke, Michael Jerosch-Herold, Alvaro Alonso, Steven M Kawut
BACKGROUND: Right ventricular (RV) morphology has been associated with drivers of atrial fibrillation (AF) risk, including left ventricular and pulmonary pathology, systemic inflammation, and neurohormonal activation. The aim of this study was to investigate the association between RV morphology and risk of incident AF. METHODS AND RESULTS: We interpreted cardiac magnetic resonance imaging in 4204 participants free of clinical cardiovascular disease in the MESA (Multi-Ethnic Study of Atherosclerosis)...
January 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28082527/ventricular-tachycardia-ablation-in-severe-heart-failure-an-international-ventricular-tachycardia-ablation-center-collaboration-analysis
#20
Wendy S Tzou, Roderick Tung, David S Frankel, Marmar Vaseghi, T Jared Bunch, Luigi Di Biase, Venkatakrishna N Tholakanahalli, Dhanunjaya Lakkireddy, Timm Dickfeld, Anastasios Saliaris, J Peter Weiss, Nilesh Mathuria, Usha Tedrow, Mohammed R Afzal, Pasquale Vergara, Koichi Nagashima, Mehul Patel, Shiro Nakahara, Kairav Vakil, J David Burkhardt, Chi-Hong Tseng, Andrea Natale, Kalyanam Shivkumar, David J Callans, William G Stevenson, Paolo Della Bella, Francis E Marchlinski, William H Sauer
BACKGROUND: Ventricular tachycardia (VT) radiofrequency ablation has been associated with reduced VT recurrence and mortality, although it is typically not considered among New York Heart Association class IV (NYHA IV) heart failure patients. We compared characteristics and VT radiofrequency ablation outcomes of those with and without NYHA IV in the International VT Ablation Center Collaboration. METHODS AND RESULTS: NYHA II-IV patients undergoing VT radiofrequency ablation at 12 international centers were included...
January 2017: Circulation. Arrhythmia and Electrophysiology
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