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Circulation. Arrhythmia and Electrophysiology

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https://www.readbyqxmd.com/read/29769224/right-ventricular-dysfunction-and-long-term-risk-of-sudden-cardiac-death-in-patients-with-and-without-severe-left-ventricular-dysfunction
#1
Niyada Naksuk, Nicholas Tan, Deepak Padmanabhan, Krishna Kancharla, Nayani Makkar, Vidhushei Yogeswaran, Prakriti Gaba, Pranita Kaginele, David C Riley, Alan M Sugrue, Andrew N Rosenbaum, Majd A El-Harasis, Samuel J Asirvatham, Suraj Kapa, Christopher J McLeod
BACKGROUND: Right ventricular systolic dysfunction (RVD) often coexists with various cardiopulmonary diseases. However, the association between RVD and risk of sudden cardiac death (SCD) has not been well studied. This study examined the risk of SCD associated with RVD in patients with heterogeneous underlying cardiac diseases. METHODS: The Mayo Clinic cardiac care unit database included 5463 consecutive patients with complete echocardiographic evaluation to assess right ventricular systolic function and RVD severity...
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29769223/comprehensive-multicenter-study-of-the-common-isthmus-in-post-atrial-fibrillation-ablation-multiple-loop-atrial-tachycardia
#2
Masateru Takigawa, Nicolas Derval, Philippe Maury, Ruairidh Martin, Arnaud Denis, Shinsuke Miyazaki, Seigo Yamashita, Antonio Frontera, Konstantinos Vlachos, Takeshi Kitamura, Ghassen Cheniti, Greégoire Massoullieé, Nathaniel Thompson, Claire A Martin, Michael Wolf, Xavier Pillois, Josselin Duchateau, Nicolas Klotz, Alexandre Duparc, Anne Rollin, Thomas Pambrun, Frédéric Sacher, Hubert Cochet, Mélèze Hocini, Michel Haiïssaguerre, Pierre Jaiïs
BACKGROUND: Characteristics of multiple-loop atrial tachycardia (AT) circuits have never precisely examined. METHODS: In 193 consecutive post-atrial fibrillation ablation patients with AT, 44 multiple-loop ATs including 42 dual-loop AT and 2 triple-loop AT in 41 (21.2%) were diagnosed with the high-resolution mapping system and analyzed off-line. RESULTS: In dual-loop ATs, 3 types were identified: type M, a combination of 2 anatomic macroreentrant ATs (AMATs) in 19 (43...
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29769222/transient-outward-k-current-i-to-underlies-the-right-ventricular-initiation-of-polymorphic-ventricular-tachycardia-in-a-transgenic-rabbit-model-of-long-qt-syndrome-type-1
#3
Bum-Rak Choi, Weiyan Li, Dmitry Terentyev, Anatoli Y Kabakov, Mingwang Zhong, Colin M Rees, Radmila Terentyeva, Tae Yun Kim, Zhilin Qu, Xuwen Peng, Alain Karma, Gideon Koren
BACKGROUND: Sudden death in long-QT syndrome type 1 (LQT1), an inherited disease caused by loss-of-function mutations in KCNQ1, is triggered by early afterdepolarizations (EADs) that initiate polymorphic ventricular tachycardia (pVT). We investigated ionic mechanisms that underlie pVT in LQT1 using a transgenic rabbit model of LQT1. METHODS: Optical mapping, cellular patch clamping, and computer modeling were used to elucidate the mechanisms of EADs in transgenic LQT1 rabbits...
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29752378/pulmonary-vein-stenosis-after-atrial-fibrillation-ablation-an-iatrogenic-problem-larger-than-the-primary-problem
#4
EDITORIAL
Santosh K Padala, Kenneth A Ellenbogen
No abstract text is available yet for this article.
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29752377/outcomes-and-management-of-patients-with-severe-pulmonary-vein-stenosis-from-prior-atrial-fibrillation-ablation
#5
Pejman Raeisi-Giglou, Oussama M Wazni, Walid I Saliba, Amr Barakat, Khaldoun G Tarakji, John Rickard, Daniel Cantillon, Bryan Baranowski, Patrick J Tchou, Mandeep Bhargava, Thomas J Dresing, Thomas D Callahan, Mohamed Kanj, Bruce D Lindsay, Ayman A Hussein
BACKGROUND: Pulmonary vein (PV) stenosis remains a feared complication of atrial fibrillation ablation. Little is known about outcomes in patients with severe PV stenosis, especially about repeat ablations. METHODS: In 10 368 patients undergoing atrial fibrillation ablation (2000-2015), computed tomography scans were obtained 3 to 6 months after ablation. The clinical outcomes in severe PV stenosis were determined. RESULTS: Severe PV stenosis was diagnosed in 52 patients (0...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29752376/effects-of-prolonged-spaceflight-on-atrial-size-atrial-electrophysiology-and-risk-of-atrial-fibrillation
#6
Htet W Khine, Katarina Steding-Ehrenborg, Jeffrey L Hastings, Jamie Kowal, James D Daniels, Richard L Page, Jeffery J Goldberger, Jason Ng, Beverley Adams-Huet, Michael W Bungo, Benjamin D Levine
BACKGROUND: The prevalence of atrial fibrillation (AF) in active astronauts is ≈5%, similar to the general population but at a younger age. Risk factors for AF include left atrial enlargement, increased number of premature atrial complexes, and certain parameters on signal-averaged electrocardiography, such as P-wave duration, root mean square voltage for the terminal 20 ms of the signal-averaged P wave, and P-wave amplitude. We aimed to evaluate changes in atrial structure, supraventricular beats, and atrial electrophysiology to determine whether spaceflight could increase the risk of AF...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29752375/functional-invalidation-of-putative-sudden-infant-death-syndrome-associated-variants-in-the-kcnh2-encoded-kv11-1-channel
#7
Jennifer L Smith, David J Tester, Allison R Hall, Don E Burgess, Chun-Chun Hsu, Samy Claude Elayi, Corey L Anderson, Craig T January, Jonathan Z Luo, Dustin N Hartzel, Uyenlinh L Mirshahi, Michael F Murray, Tooraj Mirshahi, Michael J Ackerman, Brian P Delisle
BACKGROUND: Heterologous functional validation studies of putative long-QT syndrome subtype 2-associated variants clarify their pathological potential and identify disease mechanism(s) for most variants studied. The purpose of this study is to clarify the pathological potential for rare nonsynonymous KCNH2 variants seemingly associated with sudden infant death syndrome. METHODS: Genetic testing of 292 sudden infant death syndrome cases identified 9 KCNH2 variants: E90K, R181Q, A190T, G294V, R791W, P967L, R1005W, R1047L, and Q1068R...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29748197/minimally-invasive-delivery-of-hydrogel-encapsulated-amiodarone-to-the-epicardium-reduces-atrial-fibrillation
#8
Jose R Garcia, Peter F Campbell, Gautam Kumar, Jonathan J Langberg, Liliana Cesar, Juline N Deppen, Eric Y Shin, Neal K Bhatia, Lanfang Wang, Kai Xu, Frank Schneider, Brian Robinson, Andrés J García, Rebecca D Levit
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Although treatment options for AF exist, many patients cannot be maintained in normal sinus rhythm. Amiodarone is an effective medication for AF but has limited clinical utility because of off-target tissue toxicity. METHODS: Here, we use a pig model of AF to test the efficacy of an amiodarone-containing polyethylene glycol-based hydrogel. The gel is placed directly on the atrial epicardium through the pericardial space in a minimally invasive procedure using a specially designed catheter...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29748196/interleukin-10-treatment-ameliorates-high-fat-diet-induced-inflammatory-atrial-remodeling-and-fibrillation
#9
(no author information available yet)
BACKGROUND: Obesity, characterized by systemic low-grade inflammation, is considered a well-known risk for atrial fibrillation. In fact, IL-10 (interleukin 10), which is a potent anti-inflammatory cytokine, has been reported to decrease in obese and diabetic patients. We tested the hypotheses forwarding that genetic deletion of IL-10 exacerbates high-fat diet (HFD)-induced obesity-caused atrial inflammation, lipidosis, fibrosis, and fibrillation and that IL-10 therapy inhibits this pathology...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29748195/does-high-intensity-endurance-training-increase-the-risk-of-atrial-fibrillation-a-longitudinal-study-of-left-atrial-structure-and-function
#10
Mildred A Opondo, Norman Aiad, Matthew A Cain, Satyam Sarma, Erin Howden, Douglas A Stoller, Jason Ng, Pieter van Rijckevorsel, Michinari Hieda, Takashi Tarumi, M Dean Palmer, Benjamin D Levine
BACKGROUND: Exercise mitigates many cardiovascular risk factors associated with atrial fibrillation. Endurance training has been associated with atrial structural changes which can increase the risk for atrial fibrillation. The dose of exercise training required for these changes is uncertain. We sought to evaluate the impact of exercise on left atrial (LA) mechanical and electrical function in healthy, sedentary, middle-aged adults. METHODS: Sixty-one adults (52±5 years) were randomized to either 10 months of high-intensity exercise training or yoga...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29743170/clinical-implications-of-ablation-of-drivers-for-atrial-fibrillation-a-systematic-review-and-meta-analysis
#11
Tina Baykaner, Albert J Rogers, Gabriela L Meckler, Junaid Zaman, Rachita Navara, Miguel Rodrigo, Mahmood Alhusseini, Christopher A B Kowalewski, Mohan N Viswanathan, Sanjiv M Narayan, Paul Clopton, Paul J Wang, Paul A Heidenreich
BACKGROUND: The outcomes from pulmonary vein isolation (PVI) for atrial fibrillation (AF) are suboptimal, but the benefits of additional lesion sets remain unproven. Recent studies propose ablation of AF drivers improves outcomes over PVI, yet with conflicting reports in the literature. We undertook a systematic literature review and meta-analysis to determine outcomes from ablation of AF drivers in addition to PVI or as a stand-alone procedure. METHODS: Database search was done using the terms atrial fibrillation and ablation or catheter ablation and driver or rotor or focal impulse or FIRM (Focal Impulse and Rotor Modulation)...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29700059/ventricular-electrical-activation-delay-and-high-frequency-electrocardiograms-hype-or-hope
#12
EDITORIAL
Ammar M Killu, Yong-Mei Cha
No abstract text is available yet for this article.
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29700058/impact-of-female-sex-on-clinical-outcomes-in-the-fire-and-ice-trial-of-catheter-ablation-for-atrial-fibrillation
#13
Karl-Heinz Kuck, Josep Brugada, Alexander Fürnkranz, K R Julian Chun, Andreas Metzner, Feifan Ouyang, Michael Schlüter, Arif Elvan, Kendra M Braegelmann, Fred J Kueffer, Thomas Arentz, Jean-Paul Albenque, Michael Kühne, Christian Sticherling, Claudio Tondo
BACKGROUND: Data on predictors of long-term clinical outcomes after catheter ablation of atrial fibrillation (AF) are limited. We sought to assess the association of baseline covariates with clinical outcomes in the 750 patients with drug-refractory paroxysmal AF enrolled in FIRE AND ICE. METHODS: In a 2-part analysis, univariate and multivariable Cox regression models were first used to identify baseline patient characteristics predictive of catheter ablation efficacy determined by the clinical end points of (1) atrial arrhythmia recurrence (primary efficacy failure), (2) cardiovascular rehospitalization, and (3) repeat ablation...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29700057/how-accurate-is-inverse-electrocardiographic-mapping-a-systematic-in-vivo-evaluation
#14
Laura R Bear, Ian J LeGrice, Gregory B Sands, Nigel A Lever, Denis S Loiselle, David J Paterson, Leo K Cheng, Bruce H Smaill
BACKGROUND: Inverse electrocardiographic mapping reconstructs cardiac electrical activity from recorded body surface potentials. This noninvasive technique has been used to identify potential ablation targets. Despite this, there has been little systematic evaluation of its reliability. METHODS: Torso and ventricular epicardial potentials were recorded simultaneously in anesthetized, closed-chest pigs (n=5), during sinus rhythm, epicardial, and endocardial ventricular pacing (70 records in total)...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29700056/ablation-of-the-ligament-of-marshall-and-left-stellate-ganglion-similarly-reduces-ventricular-arrhythmias-during-acute-myocardial-infarction
#15
Shan Liu, Xiaomei Yu, Da Luo, Zhiliang Qin, Xiaoying Wang, Wenbo He, Ruisong Ma, Huihui Hu, Jing Xie, Bo He, Zhibing Lu, Hong Jiang
BACKGROUND: Sympathetic denervation exerts protective effects against ventricular arrhythmias (VAs) induced by acute myocardial infarction. The results of a previous study indicated that the distal part of the ligament of Marshall (LOMLSPV ) might be a sympathetic conduit between the left stellate ganglion (LSG) and the ventricles. The present study was designed to compare the effects between LSG and LOMLSPV ablation on ischemia-induced VAs. METHODS: Twenty-nine dogs were randomly divided into sham ablation group (group 1, n=9), LOMLSPV ablation group (group 2, n=10), and LSG ablation group (group 3, n=10)...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29700055/hot-balloon-versus-cryoballoon-ablation-for-atrial-fibrillation-lesion-characteristics-and-middle-term-outcomes
#16
Koichi Nagashima, Yasuo Okumura, Ichiro Watanabe, Shiro Nakahara, Yuichi Hori, Kazuki Iso, Ryuta Watanabe, Masaru Arai, Yuji Wakamatsu, Sayaka Kurokawa, Hiroaki Mano, Toshiko Nakai, Kimie Ohkubo, Atsushi Hirayama
BACKGROUND: Hot balloon ablation (HBA) and cryoballoon ablation (CBA) were developed to simplify ablation for atrial fibrillation. Because the lesion characteristics and efficacy of these balloon modalities have not been clarified, we compared lesion characteristics and outcomes of HBA and CBA. METHODS: Of 165 consecutive patients who underwent initial catheter ablation for atrial fibrillation, 74 propensity scorematched (37 HBA and 37 CBA) patients were included in our study...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29700054/ventricular-electrical-delay-measured-from-body-surface-ecgs-is-associated-with-cardiac-resynchronization-therapy-response-in-left-bundle-branch-block-patients-from-the-madit-crt-trial-multicenter-automatic-defibrillator-implantation-cardiac-resynchronization
#17
Filip Plesinger, Pavel Jurak, Josef Halamek, Petr Nejedly, Pavel Leinveber, Ivo Viscor, Vlastimil Vondra, Scott McNitt, Bronislava Polonsky, Arthur J Moss, Wojciech Zareba, Jean-Philippe Couderc
BACKGROUND: Although cardiac resynchronization therapy (CRT) is beneficial in heart failure patients with left bundle branch block, 30% of these patients do not respond to the therapy. Identifying these patients before implantation of the device is one of the current challenges in clinical cardiology. METHODS: We verified the diagnostic contribution and an optimized computerized approach to measuring ventricular electrical activation delay (VED) from body surface 12-lead ECGs...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29666056/in-this-issue-april
#18
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29661760/april-16th-question
#19
Amit Noheria
No abstract text is available yet for this article.
April 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29654138/response-by-zghaib-et-al-to-letter-regarding-article-standard-ablation-versus-magnetic-resonance-imaging-guided-ablation-in-the-treatment-of-ventricular-tachycardia
#20
LETTER
Tarek Zghaib, Esra G Ipek, Rozann Hansford, Hiroshi Ashikaga, Ronald D Berger, Joseph E Marine, David D Spragg, Harikrishna Tandri, Stefan L Zimmerman, Henry Halperin, Scott Brancato, Hugh Calkins, Charles Henrikson, Saman Nazarian
No abstract text is available yet for this article.
April 2018: Circulation. Arrhythmia and Electrophysiology
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