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Circulation. Arrhythmia and Electrophysiology

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https://www.readbyqxmd.com/read/28500180/induced-pluripotent-stem-cell-based-treatment-of-acquired-heart-block-the-battle-for-tomorrow-has-begun
#1
EDITORIAL
Wenbin Liang, Aizhu Lu, Darryl R Davis
No abstract text is available yet for this article.
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500179/is-tgf-%C3%AE-1-transforming-growth-factor-%C3%AE-1-an-enabler-of-myofibroblast-cardiomyocyte-cross-talk
#2
EDITORIAL
Kuljeet Kaur, José Jalife
No abstract text is available yet for this article.
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500178/electrical-substrate-elimination-in-135-consecutive-patients-with-brugada-syndrome
#3
Carlo Pappone, Josep Brugada, Gabriele Vicedomini, Giuseppe Ciconte, Francesco Manguso, Massimo Saviano, Raffaele Vitale, Amarild Cuko, Luigi Giannelli, Zarko Calovic, Manuel Conti, Paolo Pozzi, Andrea Natalizia, Simonetta Crisà, Valeria Borrelli, Ramon Brugada, Georgia Sarquella-Brugada, Marco Guazzi, Alessandro Frigiola, Lorenzo Menicanti, Vincenzo Santinelli
BACKGROUND: There is emerging evidence that localization and elimination of abnormal electric activity in the epicardial right ventricular outflow tract may be beneficial in patients with Brugada syndrome. METHODS AND RESULTS: A total of 135 symptomatic Brugada syndrome patients having implantable cardiac defibrillator were enrolled: 63 (group 1) having documented ventricular tachycardia (VT)/ventricular fibrillation (VF) and Brugada syndrome-related symptoms, and 72 (group 2) having inducible VT/VF without ECG documentation at the time of symptoms...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500177/efficacy-of-an-anatomical-approach-in-radiofrequency-catheter-ablation-of-idiopathic-ventricular-arrhythmias-originating-from-the-left-ventricular-outflow-tract
#4
Takumi Yamada, Naoki Yoshida, Harish Doppalapudi, Silvio H Litovsky, H Thomas McElderry, G Neal Kay
BACKGROUND: When anatomic obstacles preclude radiofrequency catheter ablation of idiopathic ventricular arrhythmias (VAs) originating from the left ventricular outflow tract (LVOT), an alternative approach from the anatomically opposite side (endocardial versus epicardial or above versus below the aortic valve) may be considered (anatomic ablation). The purpose of this study was to investigate the efficacy of an anatomic ablation in idiopathic LVOT VAs. METHODS AND RESULTS: We studied 229 consecutive patients with idiopathic LVOT VAs...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500176/mitral-aortic-flow-reversal-in-cardiac-resynchronization-therapy-coupling-with-ejection-and-impact-of-variations-in-atrioventricular-delay
#5
Daniel Rodríguez Muñoz, José Luis Moya Mur, Javier Moreno, Covadonga Fernández-Golfín, Eduardo Franco, Bostjan Berlot, Juan Manuel Monteagudo, Roberto Matía Francés, Antonio Hernández Madrid, José Luis Zamorano
BACKGROUND: Flow entering the left ventricle is reversed toward the outflow tract through rotating reversal flow around the mitral valve. This was thought to facilitate early ejection, but had not been proved to date. We hypothesized that perfect coupling between reversal and ejection flow would occur at optimal atrioventricular delay (AVD), contributing to its hemodynamic superiority, and evaluated its applicability for AVD optimization. METHODS AND RESULTS: Forty consecutive patients with cardiac resynchronization therapy underwent intracardiac flow analysis and AVD optimization...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500175/spatial-resolution-requirements-for-accurate-identification-of-drivers-of-atrial-fibrillation
#6
Caroline H Roney, Chris D Cantwell, Jason D Bayer, Norman A Qureshi, Phang Boon Lim, Jennifer H Tweedy, Prapa Kanagaratnam, Nicholas S Peters, Edward J Vigmond, Fu Siong Ng
BACKGROUND: Recent studies have demonstrated conflicting mechanisms underlying atrial fibrillation (AF), with the spatial resolution of data often cited as a potential reason for the disagreement. The purpose of this study was to investigate whether the variation in spatial resolution of mapping may lead to misinterpretation of the underlying mechanism in persistent AF. METHODS AND RESULTS: Simulations of rotors and focal sources were performed to estimate the minimum number of recording points required to correctly identify the underlying AF mechanism...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500174/effect-of-digoxin-use-among-medicaid-enrollees-with-atrial-fibrillation
#7
Demilade Adedinsewo, Junjun Xu, Pradyumna Agasthi, Adesoji Oderinde, Oluwatoyosi Adekeye, Rajesh Sachdeva, George Rust, Anekwe Onwuanyi
BACKGROUND: Recently published analysis of contemporary atrial fibrillation (AF) cohorts showed an association between digoxin and increased mortality and hospitalizations; however, other studies have demonstrated conflicting results. Many AF cohort studies did not or were unable to examine racial differences. Our goal was to examine risk factors for hospitalizations and mortality with digoxin use in a diverse real-world AF patient population and evaluate racial differences. METHODS AND RESULTS: We performed a retrospective cohort analysis of claims data for Medicaid beneficiaries, aged 18 to 64 years, with incident diagnosis of AF in 2008 with follow-up until December 31, 2009...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500173/tgf-%C3%AE-1-transforming-growth-factor-%C3%AE-1-plays-a-pivotal-role-in-cardiac-myofibroblast-arrhythmogenicity
#8
Nicolò Salvarani, Ange Maguy, Stefano A De Simone, Michele Miragoli, Florian Jousset, Stephan Rohr
BACKGROUND: TGF-β1 (transforming growth factor-β1) importantly contributes to cardiac fibrosis by controlling differentiation, migration, and collagen secretion of cardiac myofibroblasts. It is still elusive, however, to which extent TGF-β1 alters the electrophysiological phenotype of myofibroblasts and cardiomyocytes and whether it affects proarrhythmic myofibroblast-cardiomyocyte crosstalk observed in vitro. METHODS AND RESULTS: Patch-clamp recordings of cultured neonatal rat ventricular myofibroblasts revealed that TGF-β1, applied for 24 to 48 hours at clinically relevant concentrations (≤2...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28500172/induced-pluripotent-stem-cell-derived-cardiomyocytes-provide-in-vivo-biological-pacemaker-function
#9
Samuel Chauveau, Evgeny P Anyukhovsky, Meital Ben-Ari, Shulamit Naor, Ya-Ping Jiang, Peter Danilo, Tania Rahim, Stephanie Burke, Xiaoliang Qiu, Irina A Potapova, Sergey V Doronin, Peter R Brink, Ofer Binah, Ira S Cohen, Michael R Rosen
BACKGROUND: Although multiple approaches have been used to create biological pacemakers in animal models, induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have not been investigated for this purpose. We now report pacemaker function of iPSC-CMs in a canine model. METHODS AND RESULTS: Embryoid bodies were derived from human keratinocytes, their action potential characteristics determined, and their gene expression profiles and markers of differentiation identified...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28487348/conquest-of-ventricular-tachycardia-insights-into-mechanisms-innovations-in-management-contribution-of-mark-e-josephson-md-to-clinical-electrophysiology
#10
REVIEW
Mohammad Shenasa, John M Miller, David J Callans, Jesus M Almendral, Francis E Marchlinski, Alfred E Buxton
No abstract text is available yet for this article.
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28487347/acute-and-long-term-effects-of-full-power-electroporation-ablation-directly-on-the-porcine-esophagus
#11
Kars Neven, René van Es, Vincent van Driel, Harry van Wessel, Herma Fidder, Aryan Vink, Pieter Doevendans, Fred Wittkampf
BACKGROUND: Esophageal ulceration and fistula are complications of pulmonary vein isolation using thermal energy sources. Irreversible electroporation is a novel, nonthermal ablation modality for pulmonary vein isolation. A single 200 J application can create deep myocardial lesions. Acute and chronic effects of this new energy source on the esophagus are unknown. METHODS AND RESULTS: In 8 pigs (±70 kg), the suprasternal esophagus was surgically exposed. A linear suction device with a single 35-mm long and 6-mm wide protruding linear electrode inside a plastic suction cup was used for ablation...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28473455/response-by-michowitz-and-belhassen-to-letter-regarding-article-familial-occurrence-of-atrioventricular-nodal-reentrant-tachycardia
#12
LETTER
Yoav Michowitz, Bernard Belhassen
No abstract text is available yet for this article.
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28473454/letter-by-denham-et-al-regarding-article-familial-occurrence-of-atrioventricular-nodal-reentrant-tachycardia
#13
LETTER
Nathan Denham, Charles M Pearman, Saagar Mahida
No abstract text is available yet for this article.
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28408653/drug-induced-arrhythmias-precision-medicine-and-small-data
#14
EDITORIAL
Glenn I Fishman
No abstract text is available yet for this article.
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28408652/premature-ventricular-contraction-coupling-interval-variability-destabilizes-cardiac-neuronal-and-electrophysiological-control-insights-from-simultaneous-cardioneural-mapping
#15
David Hamon, Pradeep S Rajendran, Ray W Chui, Olujimi A Ajijola, Tadanobu Irie, Ramin Talebi, Siamak Salavatian, Marmar Vaseghi, Jason S Bradfield, J Andrew Armour, Jeffrey L Ardell, Kalyanam Shivkumar
BACKGROUND: Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous system, a neural network on the heart, remains unknown. The objective was to determine the effect of PVCs and CI on intrinsic cardiac nervous system function in generating cardiac neuronal and electric instability using a novel cardioneural mapping approach...
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28408651/disease-severity-and-exercise-testing-reduce-subcutaneous-implantable-cardioverter-defibrillator-left-sternal-ecg-screening-success-in-hypertrophic-cardiomyopathy
#16
Neil T Srinivasan, Kiran H Patel, Kashif Qamar, Amy Taylor, Marco Bacà, Rui Providência, Maria Tome-Esteban, Perry M Elliott, Pier D Lambiase
BACKGROUND: The features of the hypertrophic cardiomyopathy (HCM) ECG make it a challenge for subcutaneous implantable cardioverter-defibrillator (S-ICD) screening. We aimed to investigate the causes of screening failure at rest and on exercise to inform optimal S-ICD ECG vector development. METHODS AND RESULTS: One hundred and thirty-one HCM patients (age, 50±16 years; 92 males and 39 females) with ≥1 HCM risk factor for sudden death underwent S-ICD ECG screening at rest and on exercise...
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28408650/challenges-and-pitfalls-of-entrainment-mapping-of-ventricular-tachycardia-ten-illustrative-concepts
#17
Roderick Tung
No abstract text is available yet for this article.
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28408649/external-arrhythmia-ablation-using-photon-beams-ablation-of-the-atrioventricular-junction-in-an-intact-animal-model
#18
H Immo Lehmann, Amanda J Deisher, Mitsuru Takami, Jon J Kruse, Limin Song, Sarah E Anderson, Jack T Cusma, Kay D Parker, Susan B Johnson, Samuel J Asirvatham, Robert C Miller, Michael G Herman, Douglas L Packer
BACKGROUND: This study sought to investigate external photon beam radiation for catheter-free ablation of the atrioventricular junction in intact pigs. METHODS AND RESULTS: Ten pigs were randomized to either sham irradiation or irradiation of the atrioventricular junction (55, 50, 40, and 25 Gy). Animals underwent baseline electrophysiological evaluation, cardiac gated multi-row computed tomographic imaging for beam delivery planning, and intensity-modulated radiation therapy...
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28408648/azithromycin-causes-a-novel-proarrhythmic-syndrome
#19
Zhenjiang Yang, Joseph K Prinsen, Kevin R Bersell, Wangzhen Shen, Liudmila Yermalitskaya, Tatiana Sidorova, Paula B Luis, Lynn Hall, Wei Zhang, Liping Du, Ginger Milne, Patrick Tucker, Alfred L George, Courtney M Campbell, Robert A Pickett, Christian M Shaffer, Nagesh Chopra, Tao Yang, Bjorn C Knollmann, Dan M Roden, Katherine T Murray
BACKGROUND: The widely used macrolide antibiotic azithromycin increases risk of cardiovascular and sudden cardiac death, although the underlying mechanisms are unclear. Case reports, including the one we document here, demonstrate that azithromycin can cause rapid, polymorphic ventricular tachycardia in the absence of QT prolongation, indicating a novel proarrhythmic syndrome. We investigated the electrophysiological effects of azithromycin in vivo and in vitro using mice, cardiomyocytes, and human ion channels heterologously expressed in human embryonic kidney (HEK 293) and Chinese hamster ovary (CHO) cells...
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28404608/discerning-from-the-good-the-bad-and-the-ugly
#20
EDITORIAL
Marina Cerrone
No abstract text is available yet for this article.
April 2017: Circulation. Arrhythmia and Electrophysiology
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