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Circulation. Arrhythmia and Electrophysiology

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https://www.readbyqxmd.com/read/30030266/ventricular-arrhythmias-underlie-sudden-death-in-rats-with-heart-failure-and-preserved-ejection-fraction
#1
Jae Hyung Cho, Rui Zhang, Stephan Aynaszyan, Kevin Holm, Joshua I Goldhaber, Eduardo Marbán, Eugenio Cingolani
BACKGROUND: Heart failure (HF) with preserved ejection fraction (HFpEF) is increasingly common clinically, now rivaling or exceeding HF with reduced ejection fraction . Sudden death is the leading mode of exodus in patients with HFpEF, but the underlying causes are largely unknown. Using ambulatory recordings in a rat model, we test the hypothesis that ventricular arrhythmias (VA) underlie sudden death in HFpEF. METHODS: Dahl salt-sensitive rats (7 weeks of age) were fed a high-salt diet to induce HFpEF (n=13) or a normal-salt diet (controls, n=9)...
August 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30030265/qtc-interval-and-risk-of-cardiac-events-in-adults-with-anorexia-nervosa-a-long-term-follow-up-study
#2
Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Pernille Charmoth Østergaard, Per Hove Thomsen, Claus Graff, Loa Clausen, Henrik Kjærulf Jensen
BACKGROUND: The literature contains several cases of anorexia nervosa (AN) patients with prolonged QTc interval. However, the risk of prolonged QTc interval is controversial and the risk of cardiac events in AN patients has yet to be investigated. METHODS: We estimated the difference in mean QTc interval and relative risk of borderline prolonged QTc (>440 ms) and prolonged QTc (>460 ms) between 430 adult women AN patients and 123 healthy controls using 3 correction formulas...
August 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30012874/year-in-review-in-cardiac-electrophysiology
#3
REVIEW
Suraj Kapa, Darryl R Davis, David S Park, Benjamin A Steinberg, Mohan N Viswanathan, Wendy Tzou, Malini Madhavan, Scott R Ceresnak, Paul J Wang
No abstract text is available yet for this article.
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30012873/risk-stratification-of-type-2-long-qt-syndrome-mutation-carriers-with-normal-qtc-interval-the-value-of-sex-t-wave-morphology-and-mutation-type
#4
Pyotr G Platonov, Scott McNitt, Bronislava Polonsky, Spencer Z Rosero, Valentina Kutyifa, Allison Huang, Arthur J Moss, Wojciech Zareba
BACKGROUND: Long-QT (LQT) syndrome mutation carriers have higher risk of cardiac events than unaffected family members even in the absence of QTc prolongation. Changes in T-wave morphology may reflect penetrance of LQT syndrome mutations. We aimed to assess whether T-wave morphology may improve risk stratification of LQT2 mutation carriers with normal QTc interval. METHODS: LQT2 mutation carriers with QTc <460 ms in men and <470 ms in women (n=154) were compared with unaffected family members (n=1007)...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30002068/race-and-socioeconomic-status-regulate-lifetime-risk-of-atrial-fibrillation
#5
EDITORIAL
Mark D McCauley, Dawood Darbar
No abstract text is available yet for this article.
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30002067/measuring-success-in-ablation-of-atrial-fibrillation-time-for-a-paradigm-shift
#6
EDITORIAL
Maria Terricabras, Atul Verma, Carlos A Morillo
No abstract text is available yet for this article.
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30002066/lifetime-risk-of-atrial-fibrillation-by-race-and-socioeconomic-status-aric-study-atherosclerosis-risk-in-communities
#7
Liping Mou, Faye L Norby, Lin Y Chen, Wesley T O'Neal, Tené T Lewis, Laura R Loehr, Elsayed Z Soliman, Alvaro Alonso
BACKGROUND: Limited information exists on the lifetime risk of atrial fibrillation (AF) in African Americans and by socioeconomic status. METHODS: We studied 15 343 participants without AF at baseline from the ARIC (Atherosclerosis Risk in Communities) cohort recruited in 1987 to 1989 from 4 communities in the United States when they were 45 to 64 years of age. Participants have been followed through 2014. Incidence rates of AF were calculated dividing the number of new cases by person-years of follow-up...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30002065/thirty-second-gold-standard-definition-of-atrial-fibrillation-and-its-relationship-with-subsequent-arrhythmia-patterns-analysis-of-a-large-prospective-device-database
#8
Jonathan S Steinberg, Heather O'Connell, Shelby Li, Paul D Ziegler
BACKGROUND: The Heart Rhythm Society consensus statement arbitrarily defines atrial fibrillation (AF) ablation failure as any episode ≥30 seconds. However, if brief AF events are not correlated to longer events, the rationale for this end point is questionable. We determined the impact of AF episode duration threshold on AF incidence and burden. METHODS: Patients with a pacemaker in a prospective registry with device-detected AF and follow-up >30 days were analyzed...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30002064/localized-structural-alterations-underlying-a-subset-of-unexplained-sudden-cardiac-death
#9
Michel Haïssaguerre, Mélèze Hocini, Ghassen Cheniti, Josselin Duchateau, Frédéric Sacher, Stéphane Puyo, Hubert Cochet, Masateru Takigawa, Arnaud Denis, Ruairidh Martin, Nicolas Derval, Pierre Bordachar, Philippe Ritter, Sylvain Ploux, Thomas Pambrun, Nicolas Klotz, Gregoire Massoullié, Xavier Pillois, Corentin Dallet, Jean-Jacques Schott, Solena Scouarnec, Michael J Ackerman, David Tester, Olivier Piot, Jean-Luc Pasquié, Christophe Leclerc, Jean-Sylvain Hermida, Estelle Gandjbakhch, Philippe Maury, Louis Labrousse, Ruben Coronel, Pierre Jais, David Benoist, Edward Vigmond, Mark Potse, Richard Walton, Koonlawee Nademanee, Olivier Bernus, Remi Dubois
BACKGROUND: Sudden cardiac death because of ventricular fibrillation (VF) is commonly unexplained in younger victims. Detailed electrophysiological mapping in such patients has not been reported. METHODS: We evaluated 24 patients (29±13 years) who survived idiopathic VF. First, we used multielectrode body surface recordings to identify the drivers maintaining VF. Then, we analyzed electrograms in the driver regions using endocardial and epicardial catheter mapping during sinus rhythm...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29986949/slow-and-unsteady-in-the-fast-lane
#10
EDITORIAL
Chance M Witt, Samuel J Asirvatham
No abstract text is available yet for this article.
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29986948/letter-by-schuster-regarding-article-outcomes-and-management-of-patients-with-severe-pulmonary-vein-stenosis-from-prior-atrial-fibrillation-ablation
#11
LETTER
Peter Schuster
No abstract text is available yet for this article.
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29986947/electrophysiological-characteristics-of-bundle-branch-reentry-ventricular-tachycardia-in-patients-without-structural-heart-disease
#12
Hongwu Chen, Linsheng Shi, Bing Yang, Weizhu Ju, Fengxiang Zhang, Gang Yang, Kai Gu, Mingfang Li, Kejiang Cao, Feifan Ouyang, Minglong Chen
BACKGROUND: The distinct electrophysiological features of bundle branch reentry ventricular tachycardia (VT) in patients without structural heart disease have not been systemically characterized. METHODS: Nine patients (mean age, 29.6 years) with normal left ventricular function were enrolled. Bundle branch reentry VT with right and left bundle branch block (BBB) patterns was induced in 1 and 9 patients, respectively. The right bundle was attempted to record by a 6F decapolar or quadripolar catheter...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29954742/frequency-of-cardiac-rhythm-abnormalities-in-a-half-million-adults
#13
Shaan Khurshid, Seung Hoan Choi, Lu-Chen Weng, Elizabeth Y Wang, Ludovic Trinquart, Emelia J Benjamin, Patrick T Ellinor, Steven A Lubitz
BACKGROUND: The frequency of cardiac rhythm abnormalities and their risk factors in community-dwelling adults are not well characterized. METHODS: We determined the frequency of rhythm abnormalities in the UK Biobank, a national prospective cohort. We tested associations between risk factors and incident rhythm abnormalities using multivariable proportional hazards regression. RESULTS: Of 502 627 adults (median age, 58 years [interquartile range, 13]; 54...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29945929/minimally-invasive-implantation-of-a-micropacemaker-into-the-pericardial-space
#14
Yaniv Bar-Cohen, Michael J Silka, Allison C Hill, Jay D Pruetz, Ramen H Chmait, Li Zhou, Sara M Rabin, Viktoria Norekyan, Gerald E Loeb
BACKGROUND: Permanent cardiac pacemakers require invasive procedures with complications often related to long pacemaker leads. We are developing a percutaneous pacemaker for implantation of an entire pacing system into the pericardial space. METHODS: Percutaneous micropacemaker implantations were performed in 6 pigs (27.4-34.1 kg) using subxyphoid access to the pericardial space. Modifications in the implantation methods and hardware were made after each experiment as the insertion method was optimized...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29945928/the-us-experience-of-the-wearable-cardioverter-defibrillator-in-pediatric-patients
#15
David S Spar, Nicole R Bianco, Timothy K Knilans, Richard J Czosek, Jeffrey B Anderson
BACKGROUND: Certain pediatric patients are at risk for sudden cardiac death. The wearable cardioverter-defibrillator (WCD) can be used in clinical situations in which implantable cardioverter-defibrillator placement is not ideal. The objectives of the study are to examine the effectiveness, safety, and compliance of the WCD in the identification and treatment of life-threatening ventricular arrhythmias in pediatric patients. METHODS: All United States pediatric patients <18 years who wore a WCD, from 2009 to 2016 were retrospectively reviewed...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29930156/electrocardiograms-in-healthy-north-american-children-in-the-digital-age
#16
Elizabeth V Saarel, Suzanne Granger, Jonathan R Kaltman, L LuAnn Minich, Martin Tristani-Firouzi, Jeffrey J Kim, Kathleen Ash, Sabrina S Tsao, Charles I Berul, Elizabeth A Stephenson, David G Gamboa, Felicia Trachtenberg, Peter Fischbach, Victoria L Vetter, Richard J Czosek, Tiffanie R Johnson, Jack C Salerno, Nicole B Cain, Robert H Pass, Ilana Zeltser, Eric S Silver, Joshua R Kovach, Mark E Alexander
BACKGROUND: Interpretation of pediatric ECGs is limited by lack of accurate sex- and race-specific normal reference values obtained with modern technology for all ages. We sought to obtain contemporary digital ECG measurements in healthy children from North America, to evaluate the effects of sex and race, and to compare our results to commonly used published datasets. METHODS: Digital ECGs (12-lead) were retrospectively collected for children ≤18 years old with normal echocardiograms at 19 centers in the Pediatric Heart Network...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29925536/individualized-left-anterior-oblique-projection-a-highly-reliable-patient-tailored-fluoroscopy-criterion-for-right-ventricular-lead-positioning
#17
Fabien Squara, Didier Scarlatti, Philippe Riccini, Gauthier Garret, Pamela Moceri, Emile Ferrari
BACKGROUND: Classical fluoroscopic criteria for the documentation of septal right ventricular (RV) lead positioning have poor accuracy. We sought to evaluate the individualized left anterior oblique (LAO) projection as a novel fluoroscopy criterion. METHODS: Consecutive patients undergoing pacemaker or defibrillator implantation were prospectively included. RV lead positioning was assessed by fluoroscopy using posteroanterior, right anterior oblique 30° to rule out coronary sinus positioning, and LAO 40° in the classical group or individualized LAO in the individualized group...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29925535/human-induced-pluripotent-stem-cell-derived-engineered-heart-tissue-as-a-sensitive-test-system-for-qt-prolongation-and-arrhythmic-triggers
#18
Marc D Lemoine, Tobias Krause, Jussi T Koivumäki, Maksymilian Prondzynski, Mirja L Schulze, Evaldas Girdauskas, Stephan Willems, Arne Hansen, Thomas Eschenhagen, Torsten Christ
BACKGROUND: Cardiac repolarization abnormalities in drug-induced and genetic long-QT syndrome may lead to afterdepolarizations and life-threatening ventricular arrhythmias. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) should help to overcome the limitations of animal models based on species differences in repolarization reserve. Here, we compared head-to-head the contribution of I Ks (long QT1) and I Kr (long QT2) on action potentials (APs) in human left ventricular (LV) tissue and hiPSC-CM-derived engineered heart tissue (EHT)...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29884621/catheter-ablation-of-atrial-fibrillation-a-life-or-death-situation
#19
EDITORIAL
Maria Terricabras, Atul Verma
No abstract text is available yet for this article.
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29884620/interaction-of-localized-drivers-and-disorganized-activation-in-persistent-atrial-fibrillation-reconciling-putative-mechanisms-using-multiple-mapping-techniques
#20
Christopher A B Kowalewski, Fatemah Shenasa, Miguel Rodrigo, Paul Clopton, Gabriela Meckler, Mahmood I Alhusseini, Mark A Swerdlow, Vijay Joshi, Samir Hossainy, Junaid A B Zaman, Tina Baykaner, Albert J Rogers, Johannes Brachmann, John M Miller, David E Krummen, William H Sauer, Nicholas S Peters, Paul J Wang, Sanjiv M Narayan
BACKGROUND: Mechanisms for persistent atrial fibrillation (AF) are unclear. We hypothesized that putative AF drivers and disorganized zones may interact dynamically over short time scales. We studied this interaction over prolonged durations, focusing on regions where ablation terminates persistent AF using 2 mapping methods. METHODS: We recruited 55 patients with persistent AF in whom ablation terminated AF prior to pulmonary vein isolation from a multicenter registry...
June 2018: Circulation. Arrhythmia and Electrophysiology
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