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Breast Cancer: Basic and Clinical Research

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https://www.readbyqxmd.com/read/29706765/correlation-between-mammographic-breast-density-breast-tissue-type-in-ultrasonography-fibroglandular-tissue-and-background-parenchymal-enhancement-in-magnetic-resonance-imaging
#1
Afsaneh Alikhassi, Seyedeh Nooshin Miratashi Yazdi, Hedieh Akbari, Sona Akbari Kia, Masoud Baikpour
Objective: Breast cancer is the most common malignancy in the female population, and imaging studies play a critical role for its early detection. Mammographic breast density (MBD) is one of the markers used to predict the risk stratification of breast cancer in patients. We aimed to assess the correlations among MBD, ultrasound breast composition (USBC), fibroglandular tissue (FGT), and the amount of background parenchymal enhancement (BPE) in magnetic resonance imaging, after considering the subjects' menopausal status...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29531473/analysis-of-trends-and-factors-in-breast-multiple-primary-malignant-neoplasms
#2
Igor Motuzyuk, Oleg Sydorchuk, Natalia Kovtun, Zinaida Palian, Yevhenii Kostiuchenko
Background: The study aims to evaluate the current state and tendencies in multiple primary breast cancer incidence, behavior, and treatment in Ukraine. Methods: A total of 2032 patients who received special treatment at the Department of Breast Tumors and Reconstructive Surgery of the National Cancer Institute from 2008 to 2015 were included in the study. Among them, there were 195 patients with multiple primary malignant neoplasms: 54.9% patients with synchronous cancer and 45...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29511356/evaluation-of-quantra-hologic-volumetric-computerized-breast-density-software-in-comparison-with-manual-interpretation-in-a-diverse-population
#3
Gloria Richard-Davis, Brianna Whittemore, Anthony Disher, Valerie Montgomery Rice, Rathinasamy B Lenin, Camille Dollins, Eric R Siegel, Hari Eswaran
Objective: Increased mammographic breast density is a well-established risk factor for breast cancer development, regardless of age or ethnic background. The current gold standard for categorizing breast density consists of a radiologist estimation of percent density according to the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) criteria. This study compares paired qualitative interpretations of breast density on digital mammograms with quantitative measurement of density using Hologic's Food and Drug Administration-approved R2 Quantra volumetric breast density assessment tool...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29511355/real-world-data-on-health-related-quality-of-life-assessment-in-patients-with-breast-cancer-receiving-subcutaneous-trastuzumab
#4
John Syrios, Evelina Pappa, Nikolaos Volakakis, Anastasios Grivas, John Alafis, Sofia Manioudaki, Vasiliki Tzouda, Athanasios Korogiannos, Cleopatra Rapti, Nektarios Koufopoulos, Adamantia Nikolaidou, Eleftheria Kanavou, Athanasios Alexopoulos, Anna Koumarianou
Purpose: Trastuzumab, a humanized anti-human epidermal growth factor receptor 2 (anti-HER2) antibody delivered intravenously, has revolutionized the treatment of patients with breast cancer overexpressing HER2 protein. Recently, a newer subcutaneous formulation was shown to have comparable efficacy to the initial intravenous trastuzumab. In this study, we aimed to evaluate the impact of subcutaneous trastuzumab on the health-related quality of life (HRQoL) of patients diagnosed with early or metastatic HER2-overexpressing breast cancer...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29434476/interest-of-supportive-and-barrier-protective-skin-care-products-in-the-daily-prevention-and-treatment-of-cutaneous-toxicity-during-radiotherapy-for-breast-cancer
#5
Antoine Berger, Carlos Regueiro, Tarek Hijal, David Pasquier, Cristina De La Fuente, Florence Le Tinier, Bernard Coche-Dequeant, Eric Lartigau, Dominique Moyal, Sophie Seité, René-Jean Bensadoun
Purpose: As many as 50% of patients with cancer develop acute skin reactions to some degree with radiotherapy. Proactive skin care is often recommended to minimise these skin reactions and maintain the integrity of the epidermal barrier; nevertheless, no consensual guidelines are systematically used. This multicentre, observational, prospective study evaluated the tolerability and benefit of supportive and barrier protective skin care products in preventing radiotherapy-induced skin reactions in 253 women initiating radiotherapy (exclusive or adjuvant) for breast cancer...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29434475/delays-in-breast-cancer-detection-and-treatment-in-developing-countries
#6
REVIEW
Monica M Rivera-Franco, Eucario Leon-Rodriguez
Breast cancer is the most common cancer in women in both developed and developing countries and the second most common cancer in the world. Developing countries are increasingly adopting a Western lifestyle, such as changes in diet and delayed first childbirth, lower parity, and shorter periods of breastfeeding, which are important determinants of a higher incidence of breast cancer among those regions. Low- and middle-income countries (LMICs) represent most of the countries with the highest mortality rates, ranging from 40% to 60%...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29434474/suppression-of-breast-cancer-cell-proliferation-by-selective-single-domain-antibody-for-intracellular-stat3
#7
Sunanda Singh, Genoveva Murillo, Dong Chen, Ashutosh S Parihar, Rajendra G Mehta
Background: The serendipitous discovery of heavy-chain antibodies devoid of light chains in camelids and the subsequent development of VHHs (variable region of camelid heavy chain) have provided a very important tool for research and possibly for therapeutics. In this study, we synthesized single-domain 15-kDa antibody SBT-100 (anti-STAT3 B VHH13) against human STAT3 (signal transducer and activator of transcription) that binds selectively to STAT3 and suppresses the function of phosphorylated STAT3 (p-STAT3)...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29434473/trail-induced-apoptosis-in-trail-resistant-breast-carcinoma-through-quercetin-cotreatment
#8
Jasmine M Manouchehri, Katherine A Turner, Michael Kalafatis
Breast cancer is the most commonly diagnosed cancer in women. There is a continued interest for the development of more efficacious treatment regimens for breast carcinoma. Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) shows potential as a potent anticancer therapeutic for the treatment of breast cancer, whereas displaying minimal toxicity to normal cells. However, the promise of rhTRAIL for the treatment of breast cancer is dismissed by the resistance to rhTRAIL-induced apoptosis exhibited by many breast cancers...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29434472/vitamin-d-and-breast-cancer-latest-evidence-and-future-steps
#9
REVIEW
Manar Atoum, Foad Alzoughool
Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems' functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerous health consequences; it is associated with diabetes, rheumatic arthritis, Parkinson, Alzheimer diseases, osteomalacia, osteoporosis, and fractures in adults and cancers. Many reports showed an inverse association between serum vitamin D concentration and incidence of several cancers, including breast, colorectal, kidney, lung, and pancreatic...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29434471/prognostic-significance-of-low-claudin3-expression-in-luminal-breast-cancers
#10
Lakmini Mudduwa, Harshini Peiris, Shania Gunasekara, Deepthika Abeysiriwardhana, Thusharie Liyanage
Aim: To study the prognostic value of immunohistochemically detected low Claudin3 expression in breast cancers. Methods: This retrospective study included patients with breast cancer who were investigated at our unit from 2006 to 2015. Tissue microarrays were constructed, and immunohistochemical staining was done to assess the Claudin3 expression and to classify breast cancers according to the immunohistochemical surrogates for molecular classification. Kaplan-Meier model and log-rank test were used for recurrence-free survival and breast cancer-specific survival analysis...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29434470/cognitive-behavioral-therapy-for-insomnia-mindfulness-and-yoga-in-patients-with-breast-cancer-with-sleep-disturbance-a-literature-review
#11
REVIEW
Simon B Zeichner, Rachel L Zeichner, Keerthi Gogineni, Sharon Shatil, Octavian Ioachimescu
The number of patients with breast cancer diagnosed with sleep disturbance has grown substantially within the United States over the past 20 years. Meanwhile, there have been significant improvements in the psychological treatment of sleep disturbance in patients with breast cancer. More specifically, cognitive behavioral therapy for insomnia (CBT-I), mindfulness, and yoga have shown to be 3 promising treatments with varying degrees of benefit, supporting data, and inherent limitations. In this article, we will outline the treatment approach for sleep disturbance in patients with breast cancer and conduct a comprehensive review of CBT-I, mindfulness, and yoga as they pertain to this patient population...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29434469/breast-cancer-survivors-common-markers-of-inflammation-and-exercise-a-narrative-review
#12
REVIEW
Robert Coleman Mills
Exercise may help positively improve inflammatory marker levels, therefore promoting better outcomes in breast cancer survivors. This narrative review is intended to provide an overview between inflammation and breast cancer, in addition to the effects exercise may have on common inflammatory markers that have been examined in both healthy populations and breast cancer survivors throughout the literature. The inconsistencies and gaps in the literature addressed may be important for future research to further understand the relationship between exercise and inflammation, as well as the underlying biological mechanisms that are responsible for these changes...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29147077/application-of-breast-ultrasound-elastography-to-differentiate-intracapsular-collection-from-silicone-induced-granuloma-of-breast-implant-capsule-complementarily-to-contrast-enhanced-breast-magnetic-resonance-imaging
#13
Eduardo de Faria Castro Fleury, Ana Claudia Gianini, Veronica Ayres, Luciana C Ramalho, Decio Roveda, Vilmar Marques de Oliveira
Background: To determine whether there is correlation between magnetic resonance imaging (MRI) findings and breast elastography to differentiate seroma/hematoma from silicone-induced granuloma of breast implant capsule (SIGBIC). Methods: Prospective study of 99 patients with breast implants submitted to breast MRI during the period from February 1 to May 1, 2017. Patients who present MRI findings of seroma/hematoma or SIGBIC were submitted to a complementary ultrasound elastography study to evaluate the correlation of the results...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29104428/adipose-derived-stem-cells-in-novel-approaches-to-breast-reconstruction-their-suitability-for-tissue-engineering-and-oncological-safety
#14
REVIEW
Niamh O'Halloran, Donald Courtney, Michael J Kerin, Aoife J Lowery
Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28979132/impact-of-the-tumor-microenvironment-on-tumor-infiltrating-lymphocytes-focus-on-breast-cancer
#15
REVIEW
Ivan J Cohen, Ronald Blasberg
Immunotherapy is revolutionizing cancer care across disciplines. The original success of immune checkpoint blockade in melanoma has already been translated to Food and Drug Administration-approved therapies in a number of other cancers, and a large number of clinical trials are underway in many other disease types, including breast cancer. Here, we review the basic requirements for a successful antitumor immune response, with a focus on the metabolic and physical barriers encountered by lymphocytes entering breast tumors...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28974918/high-tangent-radiation-therapy-with-field-in-field-technique-for-breast-cancer
#16
Hidekazu Tanaka, Masaya Ito, Takahiro Yamaguchi, Kae Hachiya, Takahiko Yajima, Masashi Kitahara, Katsuya Matsuyama, Satoshi Goshima, Manabu Futamura, Masayuki Matsuo
PURPOSE: We evaluated whether the field-in-field (FIF) technique improves the homogeneity of the target in high tangent radiation therapy (HTRT). MATERIALS AND METHODS: This study included 30 patients. In total, 3 HTRT plans were created: 1 with conventional opposed fields (Conv-p), 1 with the FIF technique (FIF-p), and 1 with FIF technique using lung-blocked subfields (FIF-LB-p). RESULTS: The maximum dose of the breast and planning target volume (PTV) was significantly lower for FIF-p and FIF-LB-p than Conv-p...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28615951/long-term-cause-specific-mortality-after-surgery-for-women-with-breast-cancer-a-20-year-follow-up-study-from-surveillance-epidemiology-and-end-results-cancer-registries
#17
Gabriel Escarela, Alan Jiménez-Balandra, Gabriel Núñez-Antonio, Antonio Gordillo-Moscoso
BACKGROUND: Research into long-term cause-specific mortality of women diagnosed with breast cancer is important because it allows for the splitting of the population into patients who eventually die from breast cancer and from other causes. The adoption of this approach helps to identify patients with an elevated risk of eventual death from breast cancer. OBJECTIVE: The primary aim of this study was to examine the associations between both sociodemographic and clinicopathologic characteristics and the underlying risks of death from breast cancer and from other causes for women diagnosed with breast cancer...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28469438/visualization-of-breast-microcalcifications-on-digital-breast-tomosynthesis-and-2-dimensional-digital-mammography-using-specimens
#18
Jieun Byun, Jee Eun Lee, Eun Suk Cha, Jin Chung, Jeoung Hyun Kim
PURPOSE: The purpose of this study is to compare the visibility of microcalcifications of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) using breast specimens. MATERIALS AND METHODS: Thirty-one specimens' DBT and FFDM were retrospectively reviewed by four readers. RESULTS: The image quality of microcalcifications of DBT was rated as superior or equivalent in 71.0% by reader 1, 67.8% by reader 2, 64.5% by reader 3, and 80...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28469437/predicting-adherence-to-aromatase-inhibitor-therapy-among-breast-cancer-survivors-an-application-of-the-protection-motivation-theory
#19
Monita Karmakar, Sharrel L Pinto, Timothy R Jordan, Iman Mohamed, Monica Holiday-Goodman
The purpose of this observational study was to determine if the Protection Motivation Theory could predict and explain adherence to aromatase inhibitor (AI) therapy among breast cancer survivors. Purposive sampling was used to identify 288 survivors who had been prescribed AI therapy. A valid and reliable survey was mailed to survivors. A total of 145 survivors completed the survey. The Morisky scale was used to measure adherence to AI. The survivors reported a mean score of 6.84 (±0.66) on the scale. Nearly 4 in 10 survivors (38%) were non-adherent...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28469436/breast-cancer-metastasis-to-the-axillary-lymph-nodes-are-changes-to-the-lymph-node-soil-localized-or-systemic
#20
Heather L Blackburn, Darrell L Ellsworth, Craig D Shriver, Rachel E Ellsworth
Metastasis is a multistep process that is not well understood. Colonization of a secondary organ requires specific molecular alterations of the host microenvironment. To determine the temporal and spatial changes associated with metastatic dissemination to the axillary lymph nodes, gene expression profiles were compared between histologically normal lymph nodes from node-positive patients and tumor-free nodes from node-negative patients. Using a stringent false discovery rate correction (<0.05) for multiple hypothesis testing, we did not detect any differentially expressed genes between the lymph node groups...
2017: Breast Cancer: Basic and Clinical Research
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