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Breast Cancer: Basic and Clinical Research

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https://www.readbyqxmd.com/read/28615951/long-term-cause-specific-mortality-after-surgery-for-women-with-breast-cancer-a-20-year-follow-up-study-from-surveillance-epidemiology-and-end-results-cancer-registries
#1
Gabriel Escarela, Alan Jiménez-Balandra, Gabriel Núñez-Antonio, Antonio Gordillo-Moscoso
BACKGROUND: Research into long-term cause-specific mortality of women diagnosed with breast cancer is important because it allows for the splitting of the population into patients who eventually die from breast cancer and from other causes. The adoption of this approach helps to identify patients with an elevated risk of eventual death from breast cancer. OBJECTIVE: The primary aim of this study was to examine the associations between both sociodemographic and clinicopathologic characteristics and the underlying risks of death from breast cancer and from other causes for women diagnosed with breast cancer...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28469438/visualization-of-breast-microcalcifications-on-digital-breast-tomosynthesis-and-2-dimensional-digital-mammography-using-specimens
#2
Jieun Byun, Jee Eun Lee, Eun Suk Cha, Jin Chung, Jeoung Hyun Kim
PURPOSE: The purpose of this study is to compare the visibility of microcalcifications of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) using breast specimens. MATERIALS AND METHODS: Thirty-one specimens' DBT and FFDM were retrospectively reviewed by four readers. RESULTS: The image quality of microcalcifications of DBT was rated as superior or equivalent in 71.0% by reader 1, 67.8% by reader 2, 64.5% by reader 3, and 80...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28469437/predicting-adherence-to-aromatase-inhibitor-therapy-among-breast-cancer-survivors-an-application-of-the-protection-motivation-theory
#3
Monita Karmakar, Sharrel L Pinto, Timothy R Jordan, Iman Mohamed, Monica Holiday-Goodman
The purpose of this observational study was to determine if the Protection Motivation Theory could predict and explain adherence to aromatase inhibitor (AI) therapy among breast cancer survivors. Purposive sampling was used to identify 288 survivors who had been prescribed AI therapy. A valid and reliable survey was mailed to survivors. A total of 145 survivors completed the survey. The Morisky scale was used to measure adherence to AI. The survivors reported a mean score of 6.84 (±0.66) on the scale. Nearly 4 in 10 survivors (38%) were non-adherent...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28469436/breast-cancer-metastasis-to-the-axillary-lymph-nodes-are-changes-to-the-lymph-node-soil-localized-or-systemic
#4
Heather L Blackburn, Darrell L Ellsworth, Craig D Shriver, Rachel E Ellsworth
Metastasis is a multistep process that is not well understood. Colonization of a secondary organ requires specific molecular alterations of the host microenvironment. To determine the temporal and spatial changes associated with metastatic dissemination to the axillary lymph nodes, gene expression profiles were compared between histologically normal lymph nodes from node-positive patients and tumor-free nodes from node-negative patients. Using a stringent false discovery rate correction (<0.05) for multiple hypothesis testing, we did not detect any differentially expressed genes between the lymph node groups...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28469435/inhibition-of-phosphodiesterase-5-and-increasing-the-level-of-cyclic-guanosine-3-5-monophosphate-by-hydroalcoholic-achillea-wilhelmsii-c-koch-extract-in-human-breast-cancer-cell-lines-mcf-7-and-mda-mb-468
#5
Ramin Saravani, Hamid Reza Galavi, Ali Shahraki
This study aimed to investigate the effect of hydroalcoholic Achillea wilhelmsii C. Koch extract (HAWE) on phosphodiesterase 5 (PDE5) gene expression and cyclic guanosine 3',5' monophosphate (cGMP) signaling in the MCF-7 and MDA-Mb-468 cell lines. The effective dose (ED50) of HAWE was examined in both cell lines using a 3-(4,5-dimethylhiazol-2-yl)-2,5-diphenyltetrazolium bromide viability test, and the type of cell death was detected by flow cytometry. The expression of PDE5 and the concentration of cGMP were measured in a time-dependent manner in the ED50 by real-time polymerase chain reaction and a colorimetric assay, respectively...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28096680/safety-efficacy-and-patient-acceptability-of-everolimus-in-the-treatment-of-breast-cancer
#6
REVIEW
Laurence Lousberg, Guy Jerusalem
Everolimus combined with exemestane is an important treatment option for patients suffering from estrogen receptor-positive, human epidermal growth factor receptor 2-negative, advanced breast cancer (ABC) who have been previously treated with a nonsteroidal aromatase inhibitor (NSAI). After presentation of phase III registration trial BOLERO-2, several phase IIIb trials have been started to evaluate this regimen in a more real-world setting. Here, we review the efficacy and safety data published or presented at selected international meetings...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28050129/what-you-do-not-know-could-hurt-you-what-women-wish-their-doctors-had-told-them-about-chemotherapy-side-effects-on-memory-and-response-to-alcohol
#7
Carmen E Couvertier-Lebron, Rachel Dove, Summer F Acevedo
For many patients, a cancer diagnosis is followed by chemotherapy treatment, which works by attacking cells that are growing and dividing throughout the body. Although cancer cells grow and divide more quickly than healthy cells, both are targets. The loss of healthy cells is associated with side effects, such as memory loss and altered response to a variety of food and drugs. In this pilot study, we use the "Survey of female cancer treatments, effects on memory and alcohol awareness" to explore trends in female experience and awareness of side effects associated with chemotherapy...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28008267/oncological-outcomes-and-complications-after-volume-replacement-oncoplastic-breast-conservations-the-glasgow-experience
#8
Weiguang Ho, Sheila Stallard, Julie Doughty, Elizabeth Mallon, Laszlo Romics
INTRODUCTION: Oncoplastic breast conservation surgery (OBCS) combines the principles of surgical oncology and plastic surgery. OBCS has now become a growing option for the treatment of breast cancer and forms a part of breast-conserving therapy (BCT). We sought to investigate and report our experience in two breast units in Glasgow (Victoria Infirmary and Western Infirmary) on volume replacement OBCS. MATERIALS AND METHODS: Details of patients treated with volume replacement OBCS were identified from a prospectively recorded database from November 2010 to October 2015...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27980417/clinicopathological-significance-of-tarbp2-app-and-znf395-in-breast-cancer
#9
Ryoko Oi, Hirotaka Koizumi, Ichiro Maeda, Akira Noguchi, Shinobu Tatsunami, Tsuguo Iwatani, Hisanori Kawamoto, Koichiro Tsugawa, Masayuki Takagi
The double-stranded RNA-binding protein TARBP2 has been suggested to act as an upstream regulator of breast cancer metastasis by destabilizing transcripts of the possible metastasis suppressors amyloid precursor protein (APP) and ZNF395. We examined this hypothesis by immunostaining of TARBP2, APP, and ZNF395 in 200 breast cancer specimens using tissue microarrays and analyzed the relationships between expression levels and clinicopathological parameters and prognosis. Increased TARBP2 overexpression was associated with shorter overall survival and disease-free survival, and increased but not reduced APP expression correlated with lower overall survival and disease-free survival...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27980416/the-efficacy-of-intraoperative-frozen-section-analysis-during-breast-conserving-surgery-for-patients-with-ductal-carcinoma-in-situ
#10
Mi Jin Kim, Cheol Seung Kim, Young Sam Park, Eun Hye Choi, Kyu Dam Han
INTRODUCTION: Recently, the incidence of ductal carcinoma in situ (DCIS), a noninvasive breast malignancy, has increased. This has resulted in an increase in the incidence of breast-conserving surgery (BCS). Numerous studies have suggested that intraoperative frozen section analysis (IFSA) could reduce the rate of additional excisions required to obtain adequate resection margins. However, DCIS is a known risk factor for positive margin status during BCS. Furthermore, some authors have concluded that IFSA may not be reliable for the detection of DCIS...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27867299/circulating-phospholipids-as-biomarkers-of-breast-cancer-a-review
#11
REVIEW
Dharmica April Haridatt Mistry, Peter William French
Breast cancer is the most common cancer in women and the second leading cause of cancer deaths in women. The key to surviving breast cancer is early detection and treatment. Current technologies rely heavily on imaging of the breast, and although considered the gold standard, they have their limitations. There is a need for a more accurate screening test for women of all ages, which can detect the cancer at a cellular level and before metastasis. There have been extensive studies into markers for breast cancer including protein and nucleic acid biomarkers, but to date, these have been unsuccessful...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27867298/prophylactic-bilateral-nipple-sparing-mastectomy-and-a-staged-breast-reconstruction-technique-preliminary-results
#12
Thierry Tondu, Filip Thiessen, Wiebren A A Tjalma
More high-risk women with breast cancer are identified using genetic testing at a younger age. These young women often opt for prophylactic surgery. Most patients are reluctant for extra donor-site scars besides infections and necrosis. In order to reduce these risks, a two-stage breast reconstruction technique is used for high-risk women with large or ptotic breasts. We presume that this procedure will reduce the risk of skin envelope and nipple-areola complex (NAC) necrosis to less than 1%. In the first stage, an inferior pedicle reduction is performed to obtain large volume reduction with maximal safety for the NAC...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27840578/association-of-ptp1b-with-outcomes-of-breast-cancer-patients-who-underwent-neoadjuvant-chemotherapy
#13
Monica M Rivera Franco, Eucario Leon Rodriguez, Braulio Martinez Benitez, Luisa G Villanueva Rodriguez, Maria de la Luz Sevilla Gonzalez, Alejandra Armengol Alonso
PTP1B is involved in the oncogenesis of breast cancer. In addition, neoadjuvant therapy has been widely used in breast cancer; thus, a measurement to assess survival improvement could be pathological complete response (pCR). Our objective was to associate PTP1B overexpression with outcomes of breast cancer patients who underwent neoadjuvant chemotherapy. Forty-six specimens were included. Diagnostic biopsies were immunostained using anti-PTP1B antibody. Expression was categorized as negative (<5%) and overexpression (≥5%)...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27840577/kdm4c-activity-modulates-cell-proliferation-and-chromosome-segregation-in-triple-negative-breast-cancer
#14
Jeison Garcia, Fernando Lizcano
The Jumonji-containing domain protein, KDM4C, is a histone demethylase associated with the development of several forms of human cancer. However, its specific function in the viability of tumoral lineages is yet to be determined. This work investigates the importance of KDM4C activity in cell proliferation and chromosome segregation of three triple-negative breast cancer cell lines using a specific demethylase inhibitor. Immunofluorescence assays show that KDM4C is recruited to mitotic chromosomes and that the modulation of its activity increases the number of mitotic segregation errors...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27812285/a-multifaceted-role-for-myd88-dependent-signaling-in-progression-of-murine-mammary-carcinoma
#15
Mary J Higgins, Antonio Serrano, Kofi Y Boateng, Victoria A Parsons, Tiffany Phuong, Alyssa Seifert, Jacob M Ricca, Kyle C Tucker, Alec S Eidelman, Maureen A Carey, Robert A Kurt
Previous data obtained in our laboratory suggested that there may be constitutive signaling through the myeloid differentiation primary response gene 88 (Myd88)-dependent signaling cascade in murine mammary carcinoma. Here, we extended these findings by showing that, in the absence of an added Toll-like receptor (TLR) agonist, the myddosome complex was preformed in 4T1 tumor cells, and that Myd88 influenced cytoplasmic extracellular signal-regulated kinase (Erk)1/Erk2 levels, nuclear levels of nuclear factor-kappaB (NFκB) and signal transducer and activator of transcription 5 (STAT5), tumor-derived chemokine (C-C motif) ligand 2 (CCL2) expression, and in vitro and in vivo tumor growth...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27789957/breast-cancer-awareness-and-prevention-behavior-among-women-of-delhi-india-identifying-barriers-to-early-detection
#16
Subhojit Dey, Surabhi Sharma, Arti Mishra, Suneeta Krishnan, Jyotsna Govil, Preet K Dhillon
BACKGROUND: Globally, breast cancer (BC) has become the leading cause of mortality in women. Awareness and early detection can curb the growing burden of BC and are the first step in the battle against BC. The aim of this qualitative study was to explore the awareness and perceived barriers concerning the early detection of BC. METHODS: A total of 20 focus group discussions (FGDs) were conducted during May 2013-March 2014. Pre-existing themes were used to conduct FGDs; each FGD group consisted of an average of ~10 women (aged ≥18-70 years) who came to participate in a BC awareness workshop...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27559297/genomic-changes-in-normal-breast-tissue-in-women-at-normal-risk-or-at-high-risk-for-breast-cancer
#17
REVIEW
David N Danforth
Sporadic breast cancer develops through the accumulation of molecular abnormalities in normal breast tissue, resulting from exposure to estrogens and other carcinogens beginning at adolescence and continuing throughout life. These molecular changes may take a variety of forms, including numerical and structural chromosomal abnormalities, epigenetic changes, and gene expression alterations. To characterize these abnormalities, a review of the literature has been conducted to define the molecular changes in each of the above major genomic categories in normal breast tissue considered to be either at normal risk or at high risk for sporadic breast cancer...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27499627/correction-to-breast-volume-asymmetry-value-ratio-and-cancer-risk
#18
Ragıp Kayar, Özgül V Çilengiroğlu
[This corrects the article on p. 87 in vol. 9, PMID: 26691819.].
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27478380/relevance-of-pathological-complete-response-after-neoadjuvant-therapy-for-breast-cancer
#19
REVIEW
Angela Pennisi, Thomas Kieber-Emmons, Issam Makhoul, Laura Hutchins
Breast cancer is a heterogeneous disease, and the different biological subtypes have different prognostic impacts. Neoadjuvant trials have recently become popular as they offer several advantages compared to traditional adjuvant trials. Studies have shown that patients who achieve pathological complete response (pCR) after neoadjuvant treatment have a better long-term outcome. Consequently, increasing the rate of pCR became the end point of neoadjuvant trials with the expectation of translation into improved survival...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27441001/patient-reported-outcomes-in-metastatic-breast-cancer-a-review-of-industry-sponsored-clinical-trials
#20
REVIEW
Meaghan Krohe, Yanni Hao, Roger E Lamoureux, Nina Galipeau, Denise Globe, Catherine Foley, Iyar Mazar, Jeffrey Solomon, Alan L Shields
INTRODUCTION: Patient-reported outcome (PRO) measures serve to capture vital patient information not otherwise obtained by primary study endpoints. This paper examines how PROs are utilized as endpoints in industry-sponsored metastatic breast cancer clinical trials. METHODS: A search was conducted in the clinicaltrials.gov web site for trials involving common treatments for metastatic breast cancer. Thirty-eight clinical trials were identified which included a PRO endpoint in the study, and data were extracted and summarized...
2016: Breast Cancer: Basic and Clinical Research
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