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Public Health Genomics

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https://www.readbyqxmd.com/read/29852491/assessing-genetic-literacy-awareness-and-knowledge-gaps-in-the-us-population-results-from-the-health-information-national-trends-survey
#1
Melinda Krakow, Chelsea L Ratcliff, Bradford W Hesse, Alexandra J Greenberg-Worisek
BACKGROUND/AIMS: Public understanding of the role of genetics in disease risk is key to appropriate disease prevention and detection. This study assessed the current extent of awareness and use of genetic testing in the US population. Additionally, the study identified characteristics of subgroups more likely to be at risk for low genetic literacy. METHODS: The study used data from the National Cancer Institute's 2017 Health Information National Trends Survey, including measures of genetic testing awareness, genetic testing applications and genetic testing usage...
May 31, 2018: Public Health Genomics
https://www.readbyqxmd.com/read/29723853/data-technology-and-public-health
#2
Bettina Borisch, Chukwuemeka A Iloegbu, Nadya Wells
No abstract text is available yet for this article.
May 2, 2018: Public Health Genomics
https://www.readbyqxmd.com/read/29617688/big-data-for-public-health-policy-making-policy-empowerment
#3
Laura Mählmann, Matthias Reumann, Nikolaos Evangelatos, Angela Brand
Digitization is considered to radically transform healthcare. As such, with seemingly unlimited opportunities to collect data, it will play an important role in the public health policy-making process. In this context, health data cooperatives (HDC) are a key component and core element for public health policy-making and for exploiting the potential of all the existing and rapidly emerging data sources. Being able to leverage all the data requires overcoming the computational, algorithmic, and technological challenges that characterize today's highly heterogeneous data landscape, as well as a host of diverse regulatory, normative, governance, and policy constraints...
April 4, 2018: Public Health Genomics
https://www.readbyqxmd.com/read/29689554/erratum
#4
(no author information available yet)
No abstract text is available yet for this article.
2017: Public Health Genomics
https://www.readbyqxmd.com/read/29689544/erratum
#5
(no author information available yet)
No abstract text is available yet for this article.
2017: Public Health Genomics
https://www.readbyqxmd.com/read/29439273/effects-of-diet-on-telomere-length-systematic-review-and-meta-analysis
#6
Lisiane Marçal Pérez, Marina Azambuja Amaral, Eduardo Mundstock, Florencia M Barbé-Tuana, Fátima Teresinha Costa Rodrigues Guma, Marcus H Jones, Denise Cantarelli Machado, Edgar E Sarria, Maximiniano Marques E Marques, Luiza Tweedie Preto, Matias Epifanio, João Guilherme Meinem Garbin, Rita Mattiello
BACKGROUND: The goal of this systematic review and meta-analysis is to determine the effect of diet on telomere length. METHODS: We searched the following databases: MEDLINE, Embase, LILACS, CINAHL, ISI Web of Science, and Scopus, as well as the Cochrane Central Register of Controlled Trials and the National Institutes of Health, from inception to December 2016. Articles that assessed effects of diet on telomere length were included. RESULTS: A total of 2,128 studies were identified, 30 were read in full, and 7 were systematically reviewed...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/29414817/attitudes-towards-personal-genomics-and-sharing-of-genetic-data-among-older-swiss-adults-a-qualitative-study
#7
Laura Mählmann, Sebastian Schee Gen Halfmann, Agnes von Wyl, Angela Brand
OBJECTIVE: To assess the willingness of older Swiss adults to share genetic data for research purposes and to investigate factors that might impact their willingness to share data. METHODS: Semi-structured interviews were conducted among 40 participants (19 male and 21 female) aged between 67 and 92 years, between December 2013 and April 2014 attending the Seniorenuniversität Zürich, Switzerland. All interviews were audio-recorded, transcribed verbatim, and anonymized...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/29353273/metabolomics-in-sepsis-and-its-impact-on-public-health
#8
Nikolaos Evangelatos, Pia Bauer, Matthias Reumann, Kapaettu Satyamoorthy, Hans Lehrach, Angela Brand
Sepsis, with its often devastating consequences for patients and their families, remains a major public health concern that poses an increasing financial burden. Early resuscitation together with the elucidation of the biological pathways and pathophysiological mechanisms with the use of "-omics" technologies have started changing the clinical and research landscape in sepsis. Metabolomics (i.e., the study of the metabolome), an "-omics" technology further down in the "-omics" cascade between the genome and the phenome, could be particularly fruitful in sepsis research with the potential to alter the clinical practice...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/29241213/antibiotics-induced-obesity-a-mitochondrial-perspective
#9
Melisa J Andrade, Chinchu Jayaprakash, Smitha Bhat, Nikolaos Evangelatos, Angela Brand, Kapaettu Satyamoorthy
Antibiotics are the first line of treatment against infections and have contributed immensely to reduce the morbidity and mortality rates. Recently, extensive use of antibiotics has led to alterations of the gut microbiome, predisposition to various diseases and most importantly, increase in the emergence of antibiotic-resistant bacteria, which poses a major threat to global public health. Another major issue faced worldwide due to unregulated use of antibiotics in children as well as in adults is the influence of metabolism and body weight homeostasis, leading to obesity...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/29069661/genetics-and-insurance-in-australia-concerns-around-a-self-regulated-industry
#10
Ainsley J Newson, Jane Tiller, Louise A Keogh, Margaret Otlowski, Paul Lacaze
BACKGROUND: Regulating the use of genetic information in insurance is an issue of ongoing international debate. In Australia, providers of life and other mutually rated insurance products can request applicants to disclose all results from any genetic test. Insurers can then use this information to adjust premiums and make policy decisions. The Australian Financial Services Council (FSC; an industry body) developed and maintains the relevant industry standard, which was updated in late 2016...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/29069655/online-education-and-e-consent-for-genescreen-a-preventive-genomic-screening-study
#11
R Jean Cadigan, Rita Butterfield, Christine Rini, Margaret Waltz, Kristine J Kuczynski, Kristin Muessig, Katrina A B Goddard, Gail E Henderson
BACKGROUND: Online study recruitment is increasingly popular, but we know little about the decision making that goes into joining studies in this manner. In GeneScreen, a genomic screening study that utilized online education and consent, we investigated participants' perceived ease when deciding to join and their understanding of key study features. METHODS: Individuals were recruited via mailings that directed them to a website where they could learn more about GeneScreen, consent to participate, and complete a survey...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/29050032/providing-personalised-nutrition-consumers-trust-and-preferences-regarding-sources-of-information-service-providers-and-regulators-and-communication-channels
#12
Rui Poínhos, Bruno M P M Oliveira, Ivo A van der Lans, Arnout R H Fischer, Aleksandra Berezowska, Audrey Rankin, Sharron Kuznesof, Barbara Stewart-Knox, Lynn J Frewer, Maria D V de Almeida
BACKGROUND/AIMS: Personalised nutrition has potential to revolutionise dietary health promotion if accepted by the general public. We studied trust and preferences regarding personalised nutrition services, how they influence intention to adopt these services, and cultural and social differences therein. METHODS: A total of 9,381 participants were quota-sampled to be representative of each of 9 EU countries (Germany, Greece, Ireland, Poland, Portugal, Spain, the Netherlands, the UK, and Norway) and surveyed by a questionnaire assessing their intention to adopt personalised nutrition, trust in service regulators and information sources, and preferences for service providers and information channels...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/29045944/prevalence-estimates-of-rare-congenital-anomalies-by-integrating-two-population-based-registries-in-tuscany-italy
#13
Alessio Coi, Michele Santoro, Anna Pierini, Sonia Marrucci, Federica Pieroni, Fabrizio Bianchi
BACKGROUND/AIMS: Population-based registries play a key role in the epidemiological surveillance of congenital anomalies (CAs). This study is aimed at improving the epidemiological surveillance and providing prevalence estimates of rare CAs using the Registry of Rare Diseases as an added data source to the Registry of Congenital Anomalies. METHODS: Cases of diagnosed rare CAs (2006-2013) were extracted from the Tuscany Registry of Rare Diseases and the Tuscany Registry of Congenital Anomalies in order to set up an integrated dataset...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/28858862/pancreas-cancer-precision-treatment-using-avatar-mice-from-a-bioinformatics-perspective
#14
REVIEW
Javier Perales-Patón, Elena Piñeiro-Yañez, Héctor Tejero, Pedro P López-Casas, Manuel Hidalgo, Gonzalo Gómez-López, Fátima Al-Shahrour
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death among solid malignancies. Unfortunately, PDAC lethality has not substantially decreased over the past 20 years. This aggressiveness is related to the genomic complexity and heterogeneity of PDAC, but also to the absence of an effective screening for the detection of early-stage tumors and a lack of efficient therapeutic options. Therefore, there is an urgent need to improve the arsenal of anti-PDAC drugs for an effective treatment of these patients...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/28848219/cancer-genomic-resources-and-present-needs-in-the-latin-american-region
#15
REVIEW
Ángela Torres, Javier Oliver, Cecilia Frecha, Ana Lorena Montealegre, Rosalía Quezada-Urbán, Clara Estela Díaz-Velásquez, Felipe Vaca-Paniagua, Sandra Perdomo
In Latin America (LA), cancer is the second leading cause of death, and little is known about the capacities and needs for the development of research in the field of cancer genomics. In order to evaluate the current capacity for and development of cancer genomics in LA, we collected the available information on genomics, including the number of next-generation sequencing (NGS) platforms, the number of cancer research institutions and research groups, publications in the last 10 years, educational programs, and related national cancer control policies...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/28848209/cancer-genomics-and-public-health
#16
Núria Malats, Theodora Katsila, George P Patrinos
No abstract text is available yet for this article.
2017: Public Health Genomics
https://www.readbyqxmd.com/read/28817817/assessment-of-direct-to-consumer-genetic-testing-policy-in-korea-based-on-consumer-preference
#17
Gicheol Jeong
AIMS: In June 2016, Korea permitted direct-to-consumer genetic testing (DTC-GT) on 42 genes. However, both the market and industry have not yet been fully activated. Considering the aforementioned context, this study provides important insights. METHODS: The Korean DTC-GT policy assessment is based on consumer preference analysis using a discrete choice experiment. In August 2016, a web-based survey was conducted to collect data from 1,200 respondents. RESULTS: The estimation results show that consumers prefer a DTC-GT product that is cheap, tests various items or genes, offers accurate test results, and guarantees the confidentiality of all information...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/28813717/exploring-the-use-of-a-participative-design-in-the-early-development-of-a-predictive-test-the-importance-of-physician-involvement
#18
Sophie Veilleux, Maude Villeneuve, Nathalie Lachapelle, Rita Kohen, Luc Vachon, Brian White Guay, John D Rioux, Alain Bitton
In this study, we contribute to the personalized medicine and health care management literature by developing and testing a new participative design approach. We propose that involving gastroenterologists in the development of a predictive test to assist them in their clinical decision-making process for the treatment of inflammatory bowel diseases will increase the likelihood of their acceptance of the innovation. Based on data obtained from 6 focus groups across Canada from a total of 28 physicians, analyses reveal that current tools do not enable discriminating between treatment options to find the best fit for each patient...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/28813711/subjects-at-risk-for-genetic-late-onset-neurological-diseases-objective-knowledge
#19
Ângela Leite, Fernanda Leite, Maria Alzira P Dinis
BACKGROUND/AIMS: This study addresses the objective knowledge about the disease of subjects at risk for 3 genetic late-onset neurological diseases (LOND): familial amyloid polyneuropathy (FAP) TTR V30M, Huntington disease (HD), and Machado-Joseph disease (MJD). METHODS: Subjects at risk for FAP, HD, and MJD submitted to genetic counseling to know their status (carrier or non-carrier) and subjects at risk for hereditary hemochromatosis (HH), the control group, completed a sociodemographic questionnaire and answered the open-ended question: "What do you know about this disease?...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/28723694/exosomes-a-cancer-theranostics-road-map
#20
REVIEW
Angeliki Panagiotara, Athina Markou, Evi S Lianidou, George P Patrinos, Theodora Katsila
Interindividual variability is yet to be fully characterized, and for this, optimum patient stratification and companion diagnostics are still lacking. Especially when complex disease phenotypes and/or polygenic diseases are considered, patient monitoring and disease management become rather challenging, while acquired resistance to therapy and/or toxicity events are among the unmet needs in the clinic. No doubt, biomarkers are of great importance to disease management and tailor-made theranostics. Microfluidics has gathered great attention lately, mostly due to its low-invasive nature compared to tissue biopsies...
2017: Public Health Genomics
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