journal
MENU ▼
Read by QxMD icon Read
search

Clinical and Translational Science

journal
https://www.readbyqxmd.com/read/28504483/comparison-of-a-new-intranasal-naloxone-formulation-to-intramuscular-naloxone-results-from-hypothesis-generating-small-clinical-studies
#1
Brandon T Gufford, Garrett R Ainslie, John R White, Matthew E Layton, Jeannie M Padowski, Gary M Pollack, Mary F Paine
Easy-to-use naloxone formulations are needed to help address the opioid overdose epidemic. The pharmacokinetics of intravenous, intramuscular, and a new intranasal naloxone formulation (2 mg) were compared in six healthy volunteers. Relative to intramuscular naloxone, geometric mean [90% CI] absolute bioavailability of intranasal naloxone was modestly lower (55 [43-70] versus 41 [27-62] %), whereas average (± SE) mean absorption time was substantially shorter (74 ± 8.8 versus 6.7 ± 4.9 min). The opioid-attenuating effects of intranasal naloxone were compared to intramuscular naloxone (2 mg) after administration of oral alfentanil (4 mg) to a separate group of six healthy volunteers pre-treated with 240 ml of water or grapefruit juice...
May 15, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28504421/bioinformatics-analysis-on-molecular-mechanism-of-green-tea-compound-epigallocatechin-3-gallate-against-ovarian-cancer
#2
Song Xinqiang, Zhang Mu, Chen Lei, Lee Yew Mun
Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea, and it exerts multiple effects in humans through mechanisms that remain to be clarified. The present study used bioinformatics to identify possible mechanisms by which EGCG reduces risk of ovarian cancer. Possible human protein targets of EGCG were identified in the PubChem database, possible human gene targets were identified in the NCBI database, and then both sets of targets were analyzed using Ingenuity Pathway Analysis...
May 15, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28467656/direct-oral-anticoagulants-versus-enoxaparin-for-prevention-of-venous-thromboembolism-following-orthopedic-surgery-a-dose-response-meta-analysis
#3
Rebecca A Boyd, Lorenzo DiCarlo, Jaap W Mandema
We carried out a dose-response model-based meta-analysis to assess venous thromboembolism (VTE) and bleeding with factor Xa (FXa) inhibitors (apixaban, edoxaban, rivaroxaban) and a thrombin inhibitor (dabigatran) compared with European (EU) (40 mg QD) and North American (NA) (30 mg Q12H) dose regimens of a low molecular weight heparin (enoxaparin) following orthopedic surgery. Statistically significant differences in both VTE and bleeding outcomes were found between the NA and EU doses of enoxaparin, with odds ratios [95% confidence interval] for the NA versus EU dose of 0...
May 3, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28466965/leukocyte-cell-derived-chemotaxin-2-it-s-role-in-pathophysiology-and-future-in-clinical-medicine
#4
REVIEW
Voytek Slowik, Udayan Apte
No abstract text is available yet for this article.
May 3, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28419765/intra-target-microdosing-itm-a-novel-drug-development-approach-aimed-at-enabling-safer-and-earlier-translation-of-biological-insights-into-human-testing
#5
REVIEW
T Burt, R J Noveck, D B MacLeod, A T Layton, M Rowland, G Lappin
No abstract text is available yet for this article.
April 18, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28411380/metabolic-profile-of-obeticholic-acid-and-endogenous-bile-acids-in-rats-with-decompensated-liver-cirrhosis
#6
Aldo Roda, Rita Aldini, Cecilia Camborata, Silvia Spinozzi, Placido Franco, Massimiliano Cont, Antonia D'Errico, Francesco Vasuri, Alessio Degiovanni, Lorenzo Maroni, Luciano Adorini
Obeticholic acid (OCA) is a semisynthetic bile acid (BA) analogue and potent farnesoid X receptor agonist approved to treat cholestasis. We evaluated the biodistribution and metabolism of OCA administered to CCl4 -induced cirrhotic rats. This was to ascertain if plasma and hepatic concentrations of OCA are potentially more harmful than those of endogenous BA. After administration of OCA (30 mg/kg), we used liquid chromatography-mass spectrometry to measure OCA, its metabolites, and BA at different time-points in various organs and fluids...
April 14, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28383804/gene-therapy-2017-progress-and-future-directions
#7
REVIEW
Allison M Keeler, Mai K ElMallah, Terence R Flotte
No abstract text is available yet for this article.
April 6, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28371445/influence-of-oatp1b1-function-on-the-disposition-of-sorafenib-%C3%AE-d-glucuronide
#8
S Bins, L van Doorn, M A Phelps, A A Gibson, S Hu, L Li, A Vasilyeva, G Du, P Hamberg, Falm Eskens, P de Bruijn, A Sparreboom, Rhj Mathijssen, S D Baker
The oral multikinase inhibitor sorafenib undergoes extensive UGT1A9-mediated formation of sorafenib-β-D-glucuronide (SG). Using transporter-deficient mouse models, it was previously established that SG can be extruded into bile by ABCC2 or follow a liver-to-blood shuttling loop via ABCC3-mediated efflux into the systemic circulation, and subsequent uptake in neighboring hepatocytes by OATP1B-type transporters. Here we evaluated the possibility that this unusual process, called hepatocyte hopping, is also operational in humans and can be modulated through pharmacological inhibition...
March 31, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28371388/exploratory-analysis-of-associations-between-postmarketing-safety-events-and-approved-doses-of-new-drugs-in-japan
#9
T K Okubo, S Ono
While efficient and less onerous for the industry, the globalization of clinical drug development may lead to limited efforts to optimize drugs for regional conditions. We examined the association between clinical development pathways, approved doses, and postmarketing safety risks in Japan for 135 new molecular entities approved between 2004 and 2011. The risk of drug-related deaths seemed higher when pharmaceutical companies chose exactly the same dose as in the United States, even after conducting Japanese dose-ranging studies...
March 31, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28271602/early-vision-for-the-ctsa-program-trial-innovation-network-a-perspective-from-the-national-center-for-advancing-translational-sciences-ncats
#10
Monica R Shah, Michelle A Culp, Kenneth R Gersing, Patricia L Jones, Mary E Purucker, Tiina Urv, Todd M Wilson, Petra Kaufmann
The Trial Innovation Network, an initiative of the Clinical and Translational Science Award (CTSA) Program, is a national, multi-disciplinary platform that will enable multi-center clinical trials and studies. A key goal of the Trial Innovation Network is to increase the efficiency and effectiveness of clinical trials and studies by focusing on innovation, excellence, and collaboration, leveraging the strength and expertise of the CTSA Program, and fostering partnerships among NIH, researchers, participants, providers, industry, and other stakeholders...
March 8, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28482130/candidate-gene-study-of-functional-polymorphisms-in-slco1b1-and-cyp3a4-5-and-the-cholesterol-lowering-response-to-simvastatin
#11
J P Kitzmiller, J A Luzum, A Dauki, R M Krauss, M W Medina
Cholesterol-lowering response to 40 mg simvastatin daily for 6 weeks was examined for associations with common genetic polymorphisms in key genes affecting simvastatin metabolism (CYP3A4 and CYP3A5) and transport (SLCO1B1). In white people (n = 608), SLCO1B1 521C was associated with lesser reductions of total and low-density lipoprotein cholesterol. Associations between SLCO1B1 521C and cholesterol response were not detected in African Americans (n = 333). Associations between CYP3A4*22 or CYP3A5*3 and cholesterol response were not detected in either race, and no significant race-gene or gene-gene interactions were detected...
May 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28482129/2016-reviewer-acknowledgment
#12
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28297195/clinical-pharmacology-and-translational-aspects-of-bispecific-antibodies
#13
REVIEW
A Trivedi, S Stienen, M Zhu, H Li, T Yuraszeck, J Gibbs, T Heath, R Loberg, S Kasichayanula
No abstract text is available yet for this article.
May 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28294551/the-ignite-pharmacogenetics-working-group-an-opportunity-for-building-evidence-with-pharmacogenetic-implementation-in-a-real-world-setting
#14
REVIEW
L H Cavallari, A L Beitelshees, K V Blake, L G Dressler, J D Duarte, A Elsey, J N Eichmeyer, P E Empey, J P Franciosi, J K Hicks, A M Holmes, Ljb Jeng, C R Lee, J J Lima, N A Limdi, J Modlin, A O Obeng, N Petry, V M Pratt, T C Skaar, S Tuteja, D Voora, M Wagner, K W Weitzel, R A Wilke, J F Peterson, J A Johnson
No abstract text is available yet for this article.
May 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28238224/a-comparative-toxidrome-analysis-of-human-organophosphate-and-nerve-agent-poisonings-using-social-media
#15
D S Reddy, E Colman
Here we utilized social media to compare the toxidrome of three lethal chemical exposures worldwide. YouTube videos were the main source from which the data were collected, but published reports and news were also utilized to fill in some gaps. All videos were organized in a database detailing symptoms and severity of each victim, along with demographics such as approximate age and gender. Each symptom was rated as mild, moderate, or severe and corresponding pie graphs for each incident were compared. The videos displayed symptoms ranging from mild to severe cholinergic toxicity and life-threatening convulsions...
May 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28233944/therapeutic-differences-in-24-h-ambulatory-blood-pressures-in-patients-switched-between-bioequivalent-nifedipine-osmotic-systems-with-differing-delivery-technologies
#16
P T Pollak, R J Herman, R D Feldman
Comparing modified-release formulations can be difficult using current bioequivalence criteria. Two 60-mg-once-daily nifedipine formulations are deemed bioequivalent in Canada. This study examined the validity of the assumption that these interchangeable, but different, delivery technologies are therapeutically equivalent in maintaining systolic blood pressure (SBP) control throughout the entire dosing interval. We used 24-h Ambulatory Blood Pressure Monitoring to objectively examine whether formulation switches changed population SBP >2 mmHg (reflecting 6% increased stroke mortality) and in what proportion of patients SBP changed ≥6 mmHg (risking unnecessary therapeutic alterations)...
May 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28198590/effect-of-therapeutic-and-supratherapeutic-doses-of-vonoprazan-on-the-qt-qtc-interval-in-a-phase-i-randomized-study-in-healthy-subjects
#17
B Astruc, H Jenkins, R Jenkins
This phase I, randomized, 4-period, 4-sequence, double-blind, active- and placebo-controlled, crossover study assessed the effects of vonoprazan on the QT/QTc interval in healthy subjects. Subjects received single oral doses of vonoprazan 40 mg, vonoprazan 120 mg, moxifloxacin 400 mg (positive control/open label), and placebo. The primary end point was time-matched, placebo-corrected, baseline-adjusted mean Fridericia-corrected QT interval (ddQTcF). Of 64 subjects (mean age, 37.8 years; 50% male), 63 received all four regimens...
May 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28181420/hypoxia-inducible-factor-1-a-urinary-biomarker-of-kidney-disease
#18
S Movafagh, D Raj, M Sanaei-Ardekani, D Bhatia, K Vo, M Mahmoudieh, R Rahman, E H Kim, A F Harralson
Identifying noninvasive biomarkers of kidney disease is valuable for diagnostic and therapeutic purposes. Hypoxia inducible factor 1 (HIF-1) expression is known to be elevated in the kidneys in several renal disease pathologies. We hypothesized that the urinary HIF-1a mRNA level may be a suitable biomarker for expression of this protein in chronic kidney disease (CKD). We compared HIF-1a mRNA levels from urine pellets of CKD and healthy subjects. To ensure that urinary HIF-1a mRNA is of kidney origin, we examined colocalization of HIF-1a mRNA with two kidney specific markers in urine cells...
May 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28160433/importance-of-drug-pharmacokinetics-at-the-site-of-action
#19
REVIEW
M L Rizk, L Zou, R M Savic, K E Dooley
No abstract text is available yet for this article.
May 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28160427/performance-of-redox-active-and-chelatable-iron-assays-to-determine-labile-iron-release-from-intravenous-iron-formulations
#20
A B Pai, D E Meyer, B C Bales, V E Cotero, M P Pai, N Zheng, W Jiang
Emerging data from global markets outside the United States, where many generic iron sucrose formulations are available, have revealed that non-US generic intravenous (i.v.) iron formulations may have iron release profiles that differ from the reference listed drug (RLD). The first generic i.v. iron approved in the United States was sodium ferric gluconate complex in 2011. We evaluated chelatable and redox labile iron assay methods to measure the amount of labile iron released from i.v. iron formulations in biorelevant matrices in vitro...
May 2017: Clinical and Translational Science
journal
journal
41994
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"