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Clinical and Experimental Otorhinolaryngology

Yongxin Peng
Objectives: Temporomandibular joint disorders (TMD) are often associated with aural manifestations. However, it is not clear whether aural fullness could be induced by TMD. The purpose was to investigate the TMD and effectiveness of TMD treatments in patients with mainly or exclusively aural fullness complaint. Methods: One hundred and twelve patients, who had aural fullness as the main or sole complaint, presented to the Otolaryngology Department, PLA Army General Hospital, Beijing, China, between January 2010 and January 2015...
January 21, 2017: Clinical and Experimental Otorhinolaryngology
Mahmood A Hamed, Seiichi Nakata, Kazuya Shiogama, Kenji Suzuki, Ramadan H Sayed, Yoichi Nishimura, Noboru Iwata, Kouhei Sakurai, Badawy S Badawy, Ken-Ichi Inada, Hayato Tsuge, Yutaka Tsutsumi
Objectives: Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. We aimed to investigate the expression of Ki-67, cytokeratin 13 (CK13) and cytokeratin 17 (CK17) in acquired nonrecurrent human cholesteatoma and correlate them with its bone destructive capacity. Methods: A prospective quantitative immunohistochemical study was carried out using fresh acquired cholesteatoma tissues (n=19), collected during cholesteatoma surgery...
January 12, 2017: Clinical and Experimental Otorhinolaryngology
Soon-Hyun Ahn, Hyun Jun Hong, Soon Young Kwon, Kee Hwan Kwon, Jong-Lyel Roh, Junsun Ryu, Jun Hee Park, Seung-Kuk Baek, Guk Haeng Lee, Sei Young Lee, Jin Choon Lee, Man Ki Chung, Young Hoon Joo, Yong Bae Ji, Jeong Hun Hah, Minsu Kwon, Young Min Park, Chang Myeon Song, Sung-Chan Shin, Chang Hwan Ryu, Doh Young Lee, Young Chan Lee, Jae Won Chang, Ha Min Jeong, Jae-Keun Cho, Wonjae Cha, Byung Joon Chun, Ik Joon Choi, Hyo Geun Choi, Kang Dae Lee
Objectives: Korean Society of Thyroid-Head and Neck Surgery appointed a Task Force to develop clinical practice guidelines for the surgical treatment of laryngeal cancer. Methods: This Task Force conducted a systematic search of the EMBASE, MEDLINE, Cochrane Library, and KoreaMed databases to identify relevant articles, using search terms selected according to the key questions. Evidence-based recommendations were then created on the basis of these articles. An external expert review and Delphi questionnaire were applied to reach consensus regarding the recommendations...
January 3, 2017: Clinical and Experimental Otorhinolaryngology
Min-Kwan Baek, Hyon Lee, Kyung-Ok Kim, Hyun-Jin Kwon, Myung-Hee Chung, Hyoung-Min Park, Joo-Hyun Woo, Dong-Young Kim
Objectives: Previously the authors reported age-related changes in the activities of anti-oxidative enzyme activities and protein expressions in the tongues of rats. Because more information is required about relations between aging and oxidative stress and anti-oxidative enzyme efficiency, the authors investigated differences between the expression of master regulator of anti-oxidative enzymes (nuclear factor erythroid 2-related factor 2 [Nrf2]), levels of reactive oxygen species (ROS), and mitochondrial structures in the tongues of young and aged Fischer 344 rats...
December 23, 2016: Clinical and Experimental Otorhinolaryngology
Da Jung Jung, Jae Ho Lee, Taehoon Kim, Hak-Geon Kim, Jae Young Lee, Kyu-Yup Lee
Objectives: Few studies have evaluated the accurate association between hearing loss (HL) and albuminuria in patients with or without diabetes mellitus (DM). The aim of our study was to identify the clinical effects of albuminuria on HL with or without DM. Methods: This study included 9,762 patients from the Korean National Health and Nutrition Examination Survey between 2011 and 2013. Participants were divided into 4 groups based on DM and urine albumin/creatinine ratio levels: group 1 included participants with neither DM nor albuminuria, group 2 included participants without DM and with albuminuria, group 3 included patients with DM and without albuminuria, and group 4 included patients with both DM and albuminuria...
December 23, 2016: Clinical and Experimental Otorhinolaryngology
Kyu-Sung Kim, Tae Young Jang, Young Hyo Kim
Objectives: We evaluated the clinical usefulness of Allerkin (Lofarma) for nasal provocation testing (NPT) in patients with rhinitis symptoms, by examining changes in nasal symptoms and acoustic parameters after exposure to house dust mite (HDM) extract. Methods: Twenty patients (16 males and 4 females, mean age: 29.6±14.6 years) were enrolled. We performed skin prick test (SPT) before and 15 and 30 minutes after intranasal challenge with Allerkin HDM extract, and we evaluated symptom changes (nasal obstruction, rhinorrhea, sneezing, and itching) using a visual analogue scale...
December 20, 2016: Clinical and Experimental Otorhinolaryngology
Young Hyo Kim, Kwang Pil Ko, Il Gyu Kang, Joo Hyun Jung, Dae Kyu Oh, Tae Young Jang, Seon Tae Kim
Objectives: Since Korea is geographically close to China (the origin site for Asian sand dust [ASD]) the health influence of ASD event will be still greater in Korea. We aimed to evaluate the effect of PM10 (particulate matter with aerodynamic diameter <10 μm, below 150 μg/m3) on the clinical course of allergic rhinitis (AR). Methods: We enrolled 47 healthy volunteers (group A) and 108 AR patients sensitized to house dust mites (group B). For 120 consecutive days (from February 1st to May 30th, 2012), all subjects reported their daily nasal symptoms and performed 2 peak flowmeter readings to measure peak nasal inspiratory flow (PNIF)...
December 2, 2016: Clinical and Experimental Otorhinolaryngology
Yong Tae Hong, Min Ju Park, Yu Jeong Shin, Phan Huu Ngoc Minh, Ki Hwan Hong
Objectives: Patients with bilateral vocal fold paralysis (BVFP) theoretically have difficulty producing voiceless consonants. However, perceptual studies have revealed clear production of voiceless consonants with good articulation scores in nontracheostomized patients. The purpose of this study was to clarify the production of voiceless stops during articulation in patients with BVFP compared to normal speakers. Methods: The perceptual, acoustic, and aerodynamic characteristics of patients with BVFP and those with normal speech were investigated with special reference to voiceless stop consonants...
November 17, 2016: Clinical and Experimental Otorhinolaryngology
Byungjin Kang, Jeong-Rok Kim, Jae-Min Shin, Il-Ho Park, Heung-Man Lee
Objectives: Nasal packing after endoscopic sinus surgery is frequently used to control postoperative bleeding, enhance the wound healing process, and prevent lateralization of the middle turbinate, which causes insufficient ventilation. Many biodegradable materials have been developed to reduce pain and mucosal damage during packing removal. The purpose of this study was to compare the efficacy of Guardcel (Genewel Co.) middle meatal packing with a traditional nonabsorbable middle meatal packing, Merocel (Medtronic Xomed), on wound healing and patient satisfaction...
November 17, 2016: Clinical and Experimental Otorhinolaryngology
Shicai Chen, Song Shi, Yanghui Xia, Minhui Zhu, Caiyun Zhang, Siwen Xia, Hongliang Zheng
No abstract text is available yet for this article.
December 2016: Clinical and Experimental Otorhinolaryngology
Linghao Zhang, Lu Zhang, Chun-Hong Zhang, Xiao-Bi Fang, Zhen-Xiao Huang, Qing-Yuan Shi, Li-Ping Wu, Peng Wu, Zhen-Zhen Wang, Zhi-Su Liao
OBJECTIVES: Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been much studied. METHODS: One hundred patients with CRS with nasal polyps (CRSwNP group), 40 patients with CRS without nasal polyps (CRSsNP group), and 100 patients without CRS were enrolled. The difference in lung function was compared. Meanwhile, CRSwNP and CRSsNP group were required to undergo a bronchial provocation or dilation test...
December 2016: Clinical and Experimental Otorhinolaryngology
Hanaro Park, Seung No Hong, Hyo Sang Kim, Jae Joon Han, Juyong Chung, Myung-Whan Seo, Seung-Ha Oh, Sun-O Chang, Jun Ho Lee
No abstract text is available yet for this article.
December 2016: Clinical and Experimental Otorhinolaryngology
Mahmood A Hamed, Seiichi Nakata, Ramadan H Sayed, Hiromi Ueda, Badawy S Badawy, Yoichi Nishimura, Takuro Kojima, Noboru Iwata, Ahmed R Ahmed, Khalid Dahy, Naoki Kondo, Kenji Suzuki
Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords 'aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines...
December 2016: Clinical and Experimental Otorhinolaryngology
Umit Aydogmus, Adem Topkara, Metin Akbulut, Adem Ozkan, Figen Turk, Barbaros Sahin, Gokhan Yuncu
OBJECTIVES: Mucosal free grafts may be successfully applied in many surgical interventions. This study aims at investigating the feasibility of palatal mucosa graft in sub-glottic field in an animal model. METHODS: This randomized prospective controlled study was conducted with an animal model. Sub-glottic inflammation was created in 15 adult rabbits in each group and sub-glottic stenosis surgery was applied thereafter. The rabbits in group 1 (control group) underwent segmental resection, partial cricoidectomy, and trachea-thyroid cartilage anastomosis; the rabbits in group 2 underwent segmental resection, cricoplasty, and crico-tracheal anastomosis using free buccal mucosa graft; and the rabbits in group 3 underwent segmental resection, cricoplasty, and crico-tracheal anastomosis using free palatal mucosa graft...
December 2016: Clinical and Experimental Otorhinolaryngology
Jun Ho Lee, Joong Seob Lee, Dong-Kyu Kim, Chan Hum Park, Hae Ran Lee
No abstract text is available yet for this article.
December 2016: Clinical and Experimental Otorhinolaryngology
Jana Geweiler, Johanna Inhestern, Alexander Berndt, Orlando Guntinas-Lichius
OBJECTIVES: Induction chemotherapy (IC) is likely to be effective for biologically distinct subgroups of oral cancer and biomarker development may lead to identification of those patients. METHODS: We evaluated immune cell infiltration, stroma formation and structure of the invasive front as well as the immunohistochemical expression of alpha smooth muscle actin (ASMA), CD163, E-cadherin, N-cadherin, and the laminin gamma 2 chain in pretreatment biopsy specimens and surgical resections after IC in 20 patients with locally advanced oral cancer who were treated in a prospective, ongoing, phase II trial on IC using docetaxel, cisplatin, and 5-fluorouracil (TPF)...
December 2016: Clinical and Experimental Otorhinolaryngology
Ebrahim Karimi, Seyyed Hadi Samimi Ardestani, Mehrdad Jafari, Ali Bagheri Hagh
OBJECTIVES: Free flaps are widely used to reconstruct head and neck defects. Despite the improvement in the surgical techniques and the surgeons' experiences, flap failures still occur due to thrombotic occlusion after small vessels anastomosis. To reduce the possibility of flap loss as a result of thrombotic occlusion, various anticoagulants have been used. In this study we decided to evaluate a new protocol for anticoagulation therapy and its effect on flap survival and complications...
December 2016: Clinical and Experimental Otorhinolaryngology
Nerina Denaro, Marco Carlo Merlano, Elvio Grazioso Russi
As the patients population ages, cancer screening increases, and cancer treatments improve, millions more head and neck carcinoma (HNC) patients will be classified as cancer survivors in the future. Change in epidemiology with human papillomavirus related HNC leads to a number of young treated patients. After treatment for HNC intensive surveillance, including ear, nose and throat (ENT) endoscopy, imaging, and serology, confers a survival benefit that became less evident in unresectable recurrence. We performed a comprehensive revision of literature and analyzed the experience of our centre...
December 2016: Clinical and Experimental Otorhinolaryngology
Min-Kwan Baek, Kyung-Ok Kim, Hyun-Jin Kwon, Yong-Woo Kim, Joo-Hyun Woo, Dong-Young Kim
OBJECTIVES: Antioxidative enzyme efficiency changes in some organs with age. However, no study has been conducted on age-related antioxidant enzyme changes in tongue. In the present study, the authors investigated the activities of four antioxidative enzymes and their protein expressions in the tongues of young and old Fischer 344 rats. METHODS: Age-dependent changes in the enzyme activities of total superoxide dismutase (SOD), Mn-SOD, Cu/Zn-SOD, catalase (CAT), and glutathione peroxidase (GPx) were determined using chemical kits, and the protein expressions levels of these enzymes by Western blotting...
December 2016: Clinical and Experimental Otorhinolaryngology
Luca Bruschini, Francesca Forli, Andrea De Vito, Stefano Berrettini
OBJECTIVES: The direct acoustic cochlear implant (DACI) is among the latest developments in the field of implantable acoustic prostheses. The surgical procedure requires a mastoidectomy and a posterior-inferior tympanotomy, with access to the facial recess at the level of the oval window, in a complex and lengthy surgical approach. Here, we report a new and considerably shorter surgical approach. METHODS: The new approach involves positioning of artificial incus above the oval window through the superior-anterior tympanotomy...
December 2016: Clinical and Experimental Otorhinolaryngology
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