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Clinical and Experimental Otorhinolaryngology

Kyung Tae, Yong Bae Ji, Chang Myeon Song, Junsun Ryu
To minimize surgical morbidity and neck scarring, minimally invasive thyroidectomy and robotic/endoscopic thyroidectomy via cervical, axillary, anterior chest, breast, postauricular or transoral approaches have been developed over the past 20 years. In this article, we review the evolution of robotic and endoscopic thyroid surgery and recent advances. Among remote access approaches, the gasless transaxillary approach, bilateral axillo-breast approach, postauricular facelift approach, and transoral vestibular approach are in common use today...
September 11, 2018: Clinical and Experimental Otorhinolaryngology
Jeong-Whun Kim, Taehoon Kim, Jaeyoung Shin, Goun Choe, Hyun Jung Lim, Chae-Seo Rhee, Kyogu Lee, Sung-Woo Cho
Objectives: To develop a simple algorithm for prescreening of obstructive sleep apnea (OSA) on the basis of respiratory sounds recorded during polysomnography during all sleep stages between sleep onset and offset. Methods: Patients who underwent attended, in-laboratory, full-night polysomnography were included. For all patients, audio recordings were performed with an air-conduction microphone during polysomnography. Analyses included all sleep stages (i.e., N1, N2, N3, rapid eye movement, and waking)...
September 8, 2018: Clinical and Experimental Otorhinolaryngology
H Bengu Cobanoglu, Erkan Vuralkan, Abdullah Arslan, Bengusu Mirasoglu, A Savas Toklu
Objectives: Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. The aim of the present study was to evaluate the possible effects of hyperbaric oxygen (HBO) therapy as a protective agent in cisplatin-induced ototoxicity in rats. Methods: A total of 30 adult Wistar rats (60 ears) were divided into five equal groups...
September 8, 2018: Clinical and Experimental Otorhinolaryngology
Mi Rye Bae, Woo Seok Kang, Jong Woo Chung
Objectives: We aimed to compare clinical outcomes including hearing improvement and cholesteatoma recurrence between endoscopic and conventional microscopic surgeries in patients with attic cholesteatoma. Methods: We collected data from patients with attic cholesteatoma who were treated using endoscopic (10 patients) and microscopic (10 patients) approaches by a single surgeon. The data were retrospectively reviewed for patient characteristics, intraoperative findings, hearing levels, and follow-up clinical status...
August 31, 2018: Clinical and Experimental Otorhinolaryngology
Filiz Uzumcugil, Emre Can Celebioglu, Demet Basak Ozkaragoz, Aysun Ankay Yilbas, Basak Akca, Nazgol Lotfinagsh, Bilge Celebioglu
Objectives: The age-based Cole formula has been employed for the estimation of endotracheal tube (ETT) size due to its ease of use, but may not appropriately consider growth rates among children. Child growth is assessed by calculating the body surface area (BSA). The association between the outer diameter of an appropriate uncuffed-endotrachealtube (ETT-OD) and the BSA values of patients at 24-96 months of age was our primary outcome. Methods: Cole formula, BSA, age, height, weight and ultrasound measurement of subglottic-transverse-diameter were evaluated for correlations with correct uncuffed ETT-OD...
August 25, 2018: Clinical and Experimental Otorhinolaryngology
Qiuyang Fu, Tao Wang, Yong Liang, Yong Lin, Xiangdong Zhao, Jian Wan, Suxiao Fan
Objectives.: The energy consumption process of cochlea and neural signal transduction along the auditory pathway are highly dependent on blood oxygen supply. At present, it is under debate on whether the obstructive sleep apnea syndrome (OSAS) would affect the auditory function since the patients suffer from low oxygen saturation. Moreover, it is difficult to detect the functional state of auditory in less severe stage of OSAS. Recently, speech-evoked auditory brainstem response (speech-ABR) has been reported to be a new electrophysiological tool in characterizing the auditory dysfunction...
August 24, 2018: Clinical and Experimental Otorhinolaryngology
Yongbo Yu, Yang Yang, Jie Lu, Yaqiong Jin, Yeran Yang, Enyu Hong, Jin Shi, Feng Chen, Shujing Han, Ping Chu, Yongli Guo, Xin Ni
Objectives: To investigate the genetic causes of hearing loss with enlarged vestibular aqueduct (EVA) in two children from unrelated two Chinese families. Methods: Sanger sequencing of all coding exons in SLC26A4 (encoding Pendrin protein) was performed on the two patients, their sibling and parents respectively. To predict and visualize the potential functional outcome of the novel variant, model building, structure analysis, and in silico analysis were further conducted...
August 9, 2018: Clinical and Experimental Otorhinolaryngology
Doekmin Jeon, Nam Hyun Cho, Kibeom Park, Kanghae Kim, Mansik Jeon, Jeong Hun Jang, Jeehyun Kim
Objectives: Doppler optical coherence tomography (DOCT) is useful for both, the spatially resolved measurement of the tympanic membrane (TM) oscillation and high-resolution imaging. We demonstrated a new technique capable of providing real-time two-dimensional Doppler OCT image of rapidly oscillatory latex mini-drum and in vivo rat TM and ossicles. Methods: Using DOCT system, the oscillation of sample was measured at frequency range of 1-4 kHz at an output of 15 W...
July 27, 2018: Clinical and Experimental Otorhinolaryngology
Seog-Kyun Mun, Kyu-Hee Han, Jong Tae Baek, Suk-Won Ahn, Hyun Sang Cho, Mun Young Chang
Objectives: Hearing loss disrupts the balance of auditory-somatosensory inputs in the cochlear nucleus (CN) of the brainstem, which has been suggested to be a mechanism of tinnitus. This disruption. Results.: from maladaptive auditory-somatosensory plasticity, which is a form of axonal sprouting. Axonal sprouting is promoted by transforming growth factor (TGF)-β signaling, which can be inhibited by losartan. We investigated whether losartan prevents maladaptive auditory-somatosensory plasticity after hearing loss...
July 20, 2018: Clinical and Experimental Otorhinolaryngology
Hong Ryul Jin, Dae Woo Kim, Hahn Jin Jung
Objectives: To investigate the common causes of persistent septal deviation in revision septoplasty and to report the surgical techniques and results to correct them. Methods: A total of 100 consecutive patients (86 males) who had revision septoplasty due to persistent septal deviation from 2008 and 2014 were included in the study. Their mean age was 35.6 years and the mean follow-up duration was 9.1 months. Presenting symptoms, sites of persistent septal deviation, techniques used to correct the deviation, and surgical...
July 20, 2018: Clinical and Experimental Otorhinolaryngology
Marn Joon Park, Ji Won Kim, Yonghan Kim, Yoon Se Lee, Jong-Lyel Roh, Seung-Ho Choi, Sang Yoon Kim, Soon Yuhl Nam
Objectives: The current study aims to determine the correlation between nutritional status upon presentation and disease severity, as well as treatment and survival outcomes. Methods: Patients who were diagnosed with deep neck infection, underwent at least one surgical drainage/debridement, and had more than 1 week of hospitalization at a tertiary medical center from 2007 to 2015 were retrospectively included. Thereafter, initial serum albumin, C-reactive protein (CRP), and body mass index (BMI) were reviewed...
July 20, 2018: Clinical and Experimental Otorhinolaryngology
Nerina Denaro, Marco Carlo Merlano
Prognosis in relapsed metastatic head and neck squamous cell cancer (RM-HNSCC) is dismal. Platinum based chemotherapy in combination with Cetuximab is used in first-line setting, while no further validated options are available at progression. Immunotherapy has produced durable clinical benefit in some patients with RM-HNSCC although the premises are several patients are nonresponders. Studies are ongoing to determine predictive factors and the ideal setting/combination of novel immunotherapies. In this paper, we discuss the past and present of immunotherapy in head and neck cancer and provide an up-to-date information regarding the potential ways to improve immunotherapy outcomes in HNSCC...
July 6, 2018: Clinical and Experimental Otorhinolaryngology
Joo Hyun Park, Jungmin Ahn, Il Joon Moon
Objectives: As endoscopic instrumentation, techniques and knowledges have significantly improved recently, endoscopic ear surgery has become increasingly popular. Transcanal endoscopic ear surgery (TEES) can provide better visualization of hidden areas in the middle ear cavity during congenital cholesteatoma removal. We aimed to describe outcomes for TEES for congenital cholesteatoma in a pediatric population. Methods: Twenty-five children (age, 17 months to 9 years) with congenital cholesteatoma confined to the middle ear underwent TEES by an experienced surgeon; 13 children had been classified as Potsic stage I, seven as stage II, and five as stage III...
June 27, 2018: Clinical and Experimental Otorhinolaryngology
So Young Park, Hyuk Jae Lee, Myung Joo Shim, Dong Kee Kim, Byung Do Suh, Shi Nae Park
OBJECTIVES: The classical overlay tympanoplasty is technically difficult with some disadvantages and thus less popular. However, it is particularly useful for large, anterior perforations. In this study, we describe the technique of a modified overlay graft in the tympanoplasty coined as the swing-door overlay tympanoplasty and report its outcomes. METHODS: Retrospective review of patients undergoing the swing-door overlay tympanoplasty at a tertiary referral center between 2003 and 2016 was performed...
September 2018: Clinical and Experimental Otorhinolaryngology
Min Jae Kim, Sung Hee Bae, Sung Min Lee, Kang Hyun Lee, Dong-Kyu Kim
OBJECTIVES: Pediatric sleep-disordered breathing (SDB) is a common debilitating disorder that can adversely affect the attention and academic performance of school-age children. Unfortunately, only a few studies have examined the effect of SDB treatment on attention in pediatric populations. Therefore, the aim of this study was to prospectively investigate the effect of SDB treatment on attention in children. METHODS: This study consecutively enrolled SDB children with adenotonsillar hypertrophy...
September 2018: Clinical and Experimental Otorhinolaryngology
Kyu Young Choi, Bum Sang Lee, Jin Hwan Kim, Jung Jun Kim, Young Jang, Jong Wook Choi, Dong Jin Lee
OBJECTIVES: To study the volatile sulfur compound (VSC) concentration profile in chronic tonsillitis patients before and after tonsillectomy, and to evaluate the difference between adult and pediatric (children and adolescents) patients. METHODS: Thirty adult patients (older than 20 years old) and 30 pediatric patients (younger than 20 years old) who were assigned to get tonsillectomy due to chronic tonsillitis were enrolled in this prospective nonrandomized clinical study...
September 2018: Clinical and Experimental Otorhinolaryngology
Do Hyun Kim, Seon Ik Kim, Ho Jun Jin, Subin Kim, Se Hwan Hwang
We evaluated the effect of silicone stent use during endoscopic dacryocystorhinostomy on postoperative morbidities in comparison with versus without a silicone stent. Two authors independently searched six databases (PubMed, Embase, Scopus, the Web of Science, the Cochrane library, and Google Scholar) from inception of article collection to July 2017. The analysis included prospective randomized studies that compared intraoperative silicone stent insertion (silicone group) with no application of a silicone stent (control group), in which the outcomes of interest were success rate (lacrimal passage patent check with syringing, symptom relief, or endoscopic confirmation of fluorescein dye from the opening of Hasner's valve) and morbidities (e...
September 2018: Clinical and Experimental Otorhinolaryngology
Myung Hoon Yoo, Yang-Sun Cho, June Choi, Yun Hoon Choung, Jae-Ho Chung, Jong Woo Chung, Gyu Cheol Han, Eun-Ju Jeon, Beom Cho Jun, Dong-Kee Kim, Kyu Sung Kim, Jun Ho Lee, Kyu-Yup Lee, Seung Hwan Lee, In Seok Moon, Hong Ju Park, Shi Nae Park, Jihye Rhee, Jae Hyun Seo, Seung Geun Yeo
OBJECTIVES: The aim of this multicenter registry study was to investigate the effectiveness of ventilation tube insertion and the microbiology of otitis media with effusion (OME) in children. This part I study was conducted to evaluate the microbiological profile of children with OME who needed ventilation tube insertion. METHODS: Patients <15 years old who were diagnosed as having OME and received ventilation tube insertion were prospectively enrolled in 16 tertiary hospitals from June 2014 to December 2016...
September 2018: Clinical and Experimental Otorhinolaryngology
Numan Kökten, Oğuz Kadir Eğilmez, M Tayyar Kalcıoğlu, Mustafa Baran, A Işın Doğan Ekici
OBJECTIVES: To investigate neurotoxic effect of bone cement (BC) on facial nerve by using electrophysiological and histopathological methods. METHODS: This study included 20 male albino Wistar rats, divided into four equal groups. Group A was designed as the control group, while group B was sham group. In the group C, BC solution was dropped onto the facial nerve trunks of rats and washed with physiological saline after 5 seconds. In the group D, BC solution was dropped onto the facial nerve trunks of rats and after allowing 5 minutes to dry, wounds were closed...
September 2018: Clinical and Experimental Otorhinolaryngology
Mina Aghsoleimani, Hamid Jalilvand, Mohammad Ebrahim Mahdavi, Ahmad Reza Nazeri, Mohammad Kamali
OBJECTIVES: Directional microphone technology can enhance the speech intelligibility and listening comfort of listeners with hearing impairment. The main aim of this study is to investigate and compare the benefit derived by listeners with severe hearing loss from directional microphone technology with that derived by listeners with moderate hearing loss. METHODS: The acceptable noise levels (ANLs) of two groups of listeners with moderate or severe hearing impairment (17 subjects in each group) were measured under unaided, omnidirectional-baseline-aided, and directional-aided conditions...
September 2018: Clinical and Experimental Otorhinolaryngology
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