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Clinical and Experimental Otorhinolaryngology

Young Hyo Kim, Kwang Pil Ko, Il Gyu Kang, Joo Hyun Jung, Dae Kyu Oh, Tae Young Jang, Seon Tae Kim
Objectives: Since Korea is geographically close to China (the origin site for Asian sand dust [ASD]) the health influence of ASD event will be still greater in Korea. We aimed to evaluate the effect of PM10 (particulate matter with aerodynamic diameter <10 μm, below 150 μg/m3) on the clinical course of allergic rhinitis (AR). Methods: We enrolled 47 healthy volunteers (group A) and 108 AR patients sensitized to house dust mites (group B). For 120 consecutive days (from February 1st to May 30th, 2012), all subjects reported their daily nasal symptoms and performed 2 peak flowmeter readings to measure peak nasal inspiratory flow (PNIF)...
December 2, 2016: Clinical and Experimental Otorhinolaryngology
Sang Kuk Lee, Se A Lee, Sang Woo Seon, Jae Hyun Jung, Jong Dae Lee, Jae Young Choi, Bo Gyung Kim
Objectives: Malignant external otitis (MEO) is a potentially fatal infection of the external auditory canal, temporal bone, and skull base. Despite treatment with modern antibiotics, MEO can lead to skull base osteomyelitis. Until now, there have been few studies on the prognostic factors of MEO. Methods: We performed a retrospective study to identify prognostic factors of MEO, and a meta-analysis of other articles investigating MEO. On the basis of disease progression the 28 patients in our study were divided into 'controlled' and 'uncontrolled' groups, consisting of 12 and 16 patients, respectively...
September 27, 2016: Clinical and Experimental Otorhinolaryngology
Myung Jin Ban, Jae Hong Park, Jae Wook Kim, Ki Nam Park, Jae Yong Lee, Hee Kyung Kim, Seung Won Lee
Objectives: This study assessed the regenerative efficacy of basic fibroblast growth factor (FGF) in a rabbit model of chronic vocal fold scarring and then confirmed its utility and safety in a prospective trial of patients with this condition. Methods: FGF was injected three times, at 1-week intervals, into a chronic vocal fold scar created in a rabbit model. After 1 month, mRNA level of procollagen I, hyaluronic acid synthetase 2 (HAS 2), and matrix metalloproteinase 2 (MMP 2) were analyzed by real-time polymerase chain reaction...
September 27, 2016: Clinical and Experimental Otorhinolaryngology
Hyun Ji Kim, Dae-Young Kim, Jun Ha Hwang, Kyu-Sung Kim
Objectives: To analyze the clinical characteristics of vestibular neuritis patients with minimal canal paresis (canal paresis <25%). Methods: Patients clinically diagnosed with vestibular neuritis and treated at our institute (n=201) underwent otoneurological examination and vestibular function tests. Patients were categorized in terms of the. Results.: of caloric testing (canal paresis<25%, n=58; canal paresis≥25%, n=143). Clinical characteristics and laboratory outcomes were compared between two groups...
September 27, 2016: Clinical and Experimental Otorhinolaryngology
Hui-Fang Yang, Tung-Wei Kao, Tao-Chun Peng, Yu-Shan Sun, Fang-Yih Liaw, Chung-Ching Wang, Ju-Ting Hsueh, Wei-Liang Chen
Objectives: The effects of serum uric acid (UA) level on a variety of diseases were found from experimental and observational studies via oxidative stress and anti-oxidants. However, research on the association of UA and hearing thresholds is relatively sparse. We investigated this issue in the U.S. general population to evaluate the relationship of serum UA levels and pure tone threshold of hearing. Methods: Forty four thousand eighty four eligible participants aged 20 to 69 years who have serum UA data and received Audiometry Examination Component were enrolled from the National Health and Nutrition Examination Survey 1999-2004...
September 8, 2016: Clinical and Experimental Otorhinolaryngology
Shicai Chen, Song Shi, Yanghui Xia, Minhui Zhu, Caiyun Zhang, Siwen Xia, Hongliang Zheng
No abstract text is available yet for this article.
December 2016: Clinical and Experimental Otorhinolaryngology
Linghao Zhang, Lu Zhang, Chun-Hong Zhang, Xiao-Bi Fang, Zhen-Xiao Huang, Qing-Yuan Shi, Li-Ping Wu, Peng Wu, Zhen-Zhen Wang, Zhi-Su Liao
OBJECTIVES: Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been much studied. METHODS: One hundred patients with CRS with nasal polyps (CRSwNP group), 40 patients with CRS without nasal polyps (CRSsNP group), and 100 patients without CRS were enrolled. The difference in lung function was compared. Meanwhile, CRSwNP and CRSsNP group were required to undergo a bronchial provocation or dilation test...
December 2016: Clinical and Experimental Otorhinolaryngology
Hanaro Park, Seung No Hong, Hyo Sang Kim, Jae Joon Han, Juyong Chung, Myung-Whan Seo, Seung-Ha Oh, Sun-O Chang, Jun Ho Lee
No abstract text is available yet for this article.
December 2016: Clinical and Experimental Otorhinolaryngology
Mahmood A Hamed, Seiichi Nakata, Ramadan H Sayed, Hiromi Ueda, Badawy S Badawy, Yoichi Nishimura, Takuro Kojima, Noboru Iwata, Ahmed R Ahmed, Khalid Dahy, Naoki Kondo, Kenji Suzuki
Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords 'aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines...
December 2016: Clinical and Experimental Otorhinolaryngology
Umit Aydogmus, Adem Topkara, Metin Akbulut, Adem Ozkan, Figen Turk, Barbaros Sahin, Gokhan Yuncu
OBJECTIVES: Mucosal free grafts may be successfully applied in many surgical interventions. This study aims at investigating the feasibility of palatal mucosa graft in sub-glottic field in an animal model. METHODS: This randomized prospective controlled study was conducted with an animal model. Sub-glottic inflammation was created in 15 adult rabbits in each group and sub-glottic stenosis surgery was applied thereafter. The rabbits in group 1 (control group) underwent segmental resection, partial cricoidectomy, and trachea-thyroid cartilage anastomosis; the rabbits in group 2 underwent segmental resection, cricoplasty, and crico-tracheal anastomosis using free buccal mucosa graft; and the rabbits in group 3 underwent segmental resection, cricoplasty, and crico-tracheal anastomosis using free palatal mucosa graft...
December 2016: Clinical and Experimental Otorhinolaryngology
Jun Ho Lee, Joong Seob Lee, Dong-Kyu Kim, Chan Hum Park, Hae Ran Lee
No abstract text is available yet for this article.
December 2016: Clinical and Experimental Otorhinolaryngology
Jana Geweiler, Johanna Inhestern, Alexander Berndt, Orlando Guntinas-Lichius
OBJECTIVES: Induction chemotherapy (IC) is likely to be effective for biologically distinct subgroups of oral cancer and biomarker development may lead to identification of those patients. METHODS: We evaluated immune cell infiltration, stroma formation and structure of the invasive front as well as the immunohistochemical expression of alpha smooth muscle actin (ASMA), CD163, E-cadherin, N-cadherin, and the laminin gamma 2 chain in pretreatment biopsy specimens and surgical resections after IC in 20 patients with locally advanced oral cancer who were treated in a prospective, ongoing, phase II trial on IC using docetaxel, cisplatin, and 5-fluorouracil (TPF)...
December 2016: Clinical and Experimental Otorhinolaryngology
Ebrahim Karimi, Seyyed Hadi Samimi Ardestani, Mehrdad Jafari, Ali Bagheri Hagh
OBJECTIVES: Free flaps are widely used to reconstruct head and neck defects. Despite the improvement in the surgical techniques and the surgeons' experiences, flap failures still occur due to thrombotic occlusion after small vessels anastomosis. To reduce the possibility of flap loss as a result of thrombotic occlusion, various anticoagulants have been used. In this study we decided to evaluate a new protocol for anticoagulation therapy and its effect on flap survival and complications...
December 2016: Clinical and Experimental Otorhinolaryngology
Nerina Denaro, Marco Carlo Merlano, Elvio Grazioso Russi
As the patients population ages, cancer screening increases, and cancer treatments improve, millions more head and neck carcinoma (HNC) patients will be classified as cancer survivors in the future. Change in epidemiology with human papillomavirus related HNC leads to a number of young treated patients. After treatment for HNC intensive surveillance, including ear, nose and throat (ENT) endoscopy, imaging, and serology, confers a survival benefit that became less evident in unresectable recurrence. We performed a comprehensive revision of literature and analyzed the experience of our centre...
December 2016: Clinical and Experimental Otorhinolaryngology
Min-Kwan Baek, Kyung-Ok Kim, Hyun-Jin Kwon, Yong-Woo Kim, Joo-Hyun Woo, Dong-Young Kim
OBJECTIVES: Antioxidative enzyme efficiency changes in some organs with age. However, no study has been conducted on age-related antioxidant enzyme changes in tongue. In the present study, the authors investigated the activities of four antioxidative enzymes and their protein expressions in the tongues of young and old Fischer 344 rats. METHODS: Age-dependent changes in the enzyme activities of total superoxide dismutase (SOD), Mn-SOD, Cu/Zn-SOD, catalase (CAT), and glutathione peroxidase (GPx) were determined using chemical kits, and the protein expressions levels of these enzymes by Western blotting...
December 2016: Clinical and Experimental Otorhinolaryngology
Luca Bruschini, Francesca Forli, Andrea De Vito, Stefano Berrettini
OBJECTIVES: The direct acoustic cochlear implant (DACI) is among the latest developments in the field of implantable acoustic prostheses. The surgical procedure requires a mastoidectomy and a posterior-inferior tympanotomy, with access to the facial recess at the level of the oval window, in a complex and lengthy surgical approach. Here, we report a new and considerably shorter surgical approach. METHODS: The new approach involves positioning of artificial incus above the oval window through the superior-anterior tympanotomy...
December 2016: Clinical and Experimental Otorhinolaryngology
Jong In Jeong, Hyo Yeol Kim, Sang Duk Hong, Gwanghui Ryu, Su Jin Kim, Kyung Eun Lee, Hun-Jong Dhong, Seung-Kyu Chung
OBJECTIVES: Compliance with continuous positive airway pressure (CPAP) treatment remains a primary concern for improving treatment outcomes of obstructive sleep apnea. There are few studies that have considered the role of upper airway anatomy on the compliance with CPAP. We hypothesized that upper airway anatomy would influence the compliance with CPAP. METHODS: One hundred out of 161 consecutive patients were enrolled in this study. The following possible determinants were tested against CPAP use: demographic and anthropometric data, minimal cross-sectional area on acoustic rhinometry, cephalometric and polysomnographic data, questionnaires of Epworth sleepiness scale and Beck depression index, and histories of previous upper airway surgery, degree of nasal obstruction, daily cigarette consumption, and weekly frequency of alcohol intake...
December 2016: Clinical and Experimental Otorhinolaryngology
Tae Young Jang, Ah-Yeoun Jung, Young Hyo Kim
OBJECTIVES: Antiorthostatic suspension (AOS) is ground-based model of simulated microgravity. There is still no study about the effect of long-term microgravity on the clinical course of acute lung injury. We evaluated the effect of simulated microgravity using AOS in a murine model of acute lung injury by lipopolysaccharide (LPS). METHODS: Thirty BALB/c mice were used. During 4 weeks, mice were equally allocated to control (free movement), restraint (tail suspended, but hindlimbs not unloaded), and AOS group (hindlimb unloaded)...
December 2016: Clinical and Experimental Otorhinolaryngology
Bahtiyar Polat, Serdar Karahatay, Hakan Birkent, Mustafa Gerek
OBJECTIVES: Transnasal esophagoscopy (TNE) is a relatively new diagnostic procedure in the evaluation of patients with globus sensation and dysphagia. Enabling doctors to examine all of the upper aerodigestive system without the need for sedation, this technique is becoming more popular among otolaryngology specialists. The aim of this study is to evaluate the practicability of TNE and tolerability of patients to the test. METHODS: The study group consisted of 314 patients who were admitted to the swallowing center of a tertiary medical institution with the symptoms of dysphagia and globus sensation...
December 2016: Clinical and Experimental Otorhinolaryngology
Da Jung Jung, Hyun Ho Cho, Kyu-Yup Lee
OBJECTIVES: Previous studies examining the association between osteoporosis (OP) and hearing loss (HL) have shown conflicting results. The objective of the present study was to examine the association between hearing impairment and OP in postmenopausal women, using appropriate statistical analyses. METHODS: Total 1,009 participants were included in the current study. The propensity score matched (PSM) cohort was defined as the cohort including participants diagnosed with OP and participants without OP...
December 2016: Clinical and Experimental Otorhinolaryngology
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