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Clinical and Experimental Otorhinolaryngology

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https://www.readbyqxmd.com/read/29316784/clusterin-induces-muc5ac-expression-via-activation-of-nf-%C3%AE%C2%BAb-in-human-airway-epithelial-cells
#1
Chang Hoon Bae, Hyung Gyun Na, Yoon Seok Choi, Si-Youn Song, Yong-Dae Kim
Objectives: Clusterin (CLU) is known as apolipoprotein J, and has three isoforms with different biological functions. CLU is associated with various diseases such as Alzheimer disease, atherosclerosis, and some malignancies. Recent studies report an association of CLU with inflammation and immune response in inflammatory airway diseases. However, the effect of CLU on mucin secretion of airway epithelial cells has not yet been understood. Therefore, the effect and brief signaling pathway of CLU on MUC5AC (as a major secreted mucin) expression were investigated in human airway epithelial cells...
January 11, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29310430/clinical-characteristics-and-short-term-outcomes-of-acute-low-frequency-sensorineural-hearing-loss-with-vertigo
#2
Myung Jin Park, Sang Hoon Kim, Sung Su Kim, Seung Geun Yeo
Objectives: This study analyzed short-term prognosis in patients with acute low frequency hearing loss (ALHL), and also investigate hearing recovery rates in patients with ALHL accompanied vertigo. Methods: Retrospective medical record review of the patients who received treatment for ALHL between June 2005 and June 2015 were analyzed. Of the 84 patients, 53 were without vertigo, and 31 were with vertigo. Of the 31 patients, eight were treated with steroids, seven with diuretics alone, and 16 with both...
January 10, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29307173/relationship-of-vertigo-and-postural-instability-in-patients-with-vestibular-schwannoma
#3
Gi-Sung Nam, Chan Min Jung, Ji Hyung Kim, Eun Jin Son
Objectives: Growth of vestibular schwannomas (VS) causes progressive vestibular symptoms and postural instability. Since the tumor grows slowly, compensation of decaying vestibular input may decrease subjective symptoms of dizziness. This study aims to estimate the relationship of subjective vestibular symptoms and objective postural instability in patients with VS. Methods: A retrospective review of 18 patients newly diagnosed with VS and with subjective vertigo symptoms was performed...
January 9, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29307133/impact-of-nicotine-exposure-on-hair-cell-toxicity-and-embryotoxicity-during-zebrafish-development
#4
Myung Hoon Yoo, Yoon Chan Rah, Saemi Park, Soonil Goun, Gi Jung Im, Sung Won Chae, Hak Hyun Jung, June Choi
Objectives: Nicotine has various adverse effects including negative impacts associated with maternal exposure. In the current study, we examined nicotine-induced damage of hair cells and embryotoxicity during zebrafish development. Methods: Zebrafish embryos were exposed to nicotine at several concentrations (5, 10, 20, and 40 μM) and embryotoxicity were evaluated at 72 hours, including hatching rate, mortality, teratogenicity rate, and heart rate. Hair cells within the supraorbital (SO1 and SO2), otic (O1), and occipital (OC1) neuromasts were identified at 120 hours...
January 6, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29186936/endoscope-assisted-cochlear-implantation
#5
Enis Alpin Güneri, Yüksel Olgun
Objectives: Our aim was to present our endoscope-assisted cochlear implantation (CI) technique, in which the middle ear landmarks were identified through the facial recess exposure by using an endoscopic view without elevating the tympanic annulus. The secondary goal was to assess whether the situation of difficult surgical exposure could be predicted by evaluating preoperative axial computed tomography (CT) examinations. Methods: CT examinations and surgical outcomes of endoscope-assisted CI surgeries were analyzed...
December 1, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29172396/the-effect-of-endoscopic-tympanoplasty-on-cochlear-function
#6
Isa Kaya, Goksel Turhal, Arin Ozturk, Sercan Gode, Cem Bilgen, Tayfun Kirazli
Objectives: The aim of this prospective clinical study was to measure the audiologic outcomes of the patients that underwent endoscopic transcanal cartilage tympanoplasty, and to investigate the effects on cochlear function. Methods: Thirty-three patients (33 ears) who were diagnosed with noncomplicated chronic otitis media and underwent endoscopic transcanal cartilage tympanoplasty technique were included. Pre- and postoperative first month distortion product otoacoustic emission (DPOAE) signal-to-noise ratio (SNR), bone conduction hearing levels and air bone gap (ABG) values were measured and total endoscope usage time was noted...
November 28, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28866875/substance-p-and-calcitonin-gene-related-peptide-in-the-glands-of-external-auditory-canal-skin
#7
Yong Joo Yoon, Jin Yoon, Eun Jung Lee, Jong Seung Kim
OBJECTIVES: The earwax (cerumen) that covers external auditory canal (EAC) skin contains a mixture of ceruminous and sebaceous gland substances, such as lipids, peptides, and proteins. The components secreted from the ceruminous gland that is a modified sweat gland form cerumen and contain several antimicrobial factors. Since substance P (SP) and calcitonin gene-related peptide (CGRP), known as a secretagogue, have been found in sweat glands, our purpose was to determine the expression of SP and CGRP in the glands of EAC skin...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28602068/radiographic-changes-of-the-nasal-septal-body-among-patients-with-sinonasal-diseases
#8
January E Gelera, Devendra Ojar, Jae Hyun Lim, Jee Hye Wee, Jeong-Whun Kim, Chae-Seo Rhee
OBJECTIVES: This study aims to determine the anatomical changes occurring in the nasal septal body (NSB) among patients with sinonasal disease and compares the measurements obtained from patients without sinonasal disease. METHODS: This was a retrospective study involving review of 405 (93 without and 212 with sinonasal disease) plain paranasal sinus computed tomography (PNS CT) on coronal view at a tertiary training hospital, which was done consecutively from January 2014 to December 2015...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28602066/analysis-of-eustachian-tube-dysfunction-by-dynamic-slow-motion-video-endoscopy-and-eustachian-tube-dysfunction-questionnaire-in-chronic-otitis-media
#9
Won Gue Han, Jun Yoo, Yoon Chan Rah, Jiwon Chang, Gi Jung Im, Jae-Jun Song, Sung Won Chae, Hak Hyun Jung, June Choi
OBJECTIVES: Eustachian tube dysfunction has been associated with most cases of middle-ear disease. We aimed to assess the effectiveness of dynamic slow motion video endoscopy (DSVE) as a test of eustachian tube dysfunction. Furthermore, we assessed the correlation of the test with the Valsalva maneuver, the seven-item Eustachian Tube Dysfunction Questionnaire (ETDQ-7), and intraoperative findings of the eustachian tube. METHODS: We retrospectively reviewed medical records from April to September 2014 to identify patients who were diagnosed with chronic otitis media (COM) at Korea University Ansan Hospital...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28535579/review-of-heterotopic-thyroid-autotransplantation
#10
REVIEW
Mahmoud Sakr, Ahmed Mahmoud
Total thyroidectomy is increasingly accepted for the management of bilateral benign thyroid disorders. Postoperatively, patients require lifelong levothyroxine replacement therapy to avoid postoperative hypothyroidism, which besides the burden of compliance, has been proven to be associated with several long-term side effects. Heterotopic thyroid autotransplantation was proposed several decades ago to avoid the need for life-long postoperative replacement therapy with maintaining the autoregulatory mechanism of thyroxin production inside the body according to its needs...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28494527/relationships-among-factors-relevant-to-abdominal-fat-and-age-related-hearing-loss
#11
Young Lee, Mina Park
OBJECTIVES: Metabolic syndrome is related with abdominal fat and with age-related hearing loss (ARHL). In this study, we evaluated the association between a variety of factors relevant to abdominal fat (FRAs) and hearing thresholds. METHODS: We reviewed retrospectively the medical records of 2,602 subjects aged over 40 years with symmetrical sensorineural hearing loss who underwent abdominal fat computed tomography (CT) scans. Univariate and multivariate linear regression analyses were used to demonstrate the association between each FRA and hearing thresholds at low and high frequencies...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28449552/effect-of-proparacaine-in-a-mouse-model-of-allergic-rhinitis
#12
Hwan Soo Kim, Sulmui Won, Eu Kyoung Lee, Yoon Hong Chun, Jong-Seo Yoon, Jin Tack Kim, Hyun Hee Kim
OBJECTIVES: Lidocaine, a local anaesthetic is a treatment option in uncontrolled asthma due to its immunomodulatory effects. In the present study, proparacaine (PPC), a derivative of lidocaine was examined for its therapeutic application in a mouse model of allergic rhinitis. METHODS: The mice were grouped into 4 groups: control group, allergic rhinitis (AR) group, ciclesonide (CIC) group, and PPC group. Nasal symptom scores, eosinophil counts, goblet cell counts, and mast cells counts in the nasal mucosa were measured...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28449551/a-survey-of-korean-physicians-prescription-patterns-for-allergic-rhinitis
#13
Min Young Seo, Dong-Kyu Kim, Hye Mi Jee, Young Min Ahn, Yong Min Kim, Sang Duk Hong
OBJECTIVES: The aim of this study was to compare the prescription patterns according to characteristics of physicians using a survey distributed amongst physicians in Korea. METHODS: We surveyed the prescription patterns for allergic rhinitis (AR) of the members of the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI) and the Korean Association of Otorhinolaryngologists (KAO). Questionnaire contained 4 categories with 28 queries. 448 physicians including 98 internal medicine (IM), 113 pediatrics (PED), and 237 otorhinolaryngology (ENT) were responded...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28264555/the-effect-of-insulin-like-growth-factor-1-on-recovery-of-facial-nerve-crush-injury
#14
Asuman Feda Bayrak, Yuksel Olgun, Ayla Ozbakan, Safiye Aktas, Can Ahmet Kulan, Gonca Kamaci, Emine Demir, Osman Yilmaz, Levent Olgun
OBJECTIVES: The aim of this study is to investigate the efficacy of locally applied insulin-like growth factor 1 (IGF-1) on the recovery of facial nerve functions after crush injury in a rabbit model. METHODS: The rabbits were randomly assigned into three groups. Group 1 consisted of the rabbits with crush injury alone; group 2, the animals applied saline solution onto the crushed facial nerve and group 3, IGF-1 implemented to the nerve in the same manner. Facial nerve injury was first electrophysiologically studied on 10th and 42nd days of the procedure...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28264554/hearing-improvement-in-a-j-mice-via-the-mouse-nerve-growth-factor
#15
Lixiang Gao, Ruli Ge, Gang Xie, Dandan Yao, Ping Li, Oumei Wang, Xiufang Ma, Fengchan Han
OBJECTIVES: To investigate the otoprotective effects of mouse nerve growth factor (mNGF) in A/J mice. METHODS: The mice at postnatal day 7 (P7) were randomly separated into a mNGF treated group (mNGF group) and a distilled water (for injection) treated group (control group). The mNGF dissolved in distilled water or distilled water alone was given to the mice once every other day from P7 by intramuscular injection in the hips. The otoprotective effects of mNGF in A/J mice were observed in a time course manner...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28002926/age-related-changes-in-nuclear-factor-erythroid-2-related-factor-2-and-reactive-oxygen-species-and-mitochondrial-structure-in-the-tongues-of-fischer-344-rats
#16
Min-Kwan Baek, Hyon Lee, Kyung-Ok Kim, Hyun-Jin Kwon, Myung-Hee Chung, Hyoung-Min Park, Joo-Hyun Woo, Dong-Young Kim
OBJECTIVES: Previously the authors reported age-related changes in the activities of anti-oxidative enzyme activities and protein expressions in the tongues of rats. Because more information is required about relations between aging and oxidative stress and anti-oxidative enzyme efficiency, the authors investigated differences between the expression of master regulator of anti-oxidative enzymes (nuclear factor erythroid 2-related factor 2 [Nrf2]), levels of reactive oxygen species (ROS), and mitochondrial structures in the tongues of young and aged Fischer 344 rats...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/27671715/the-efficacy-of-fibroblast-growth-factor-for-the-treatment-of-chronic-vocal-fold-scarring-from-animal-model-to-clinical-application
#17
Myung Jin Ban, Jae Hong Park, Jae Wook Kim, Ki Nam Park, Jae Yong Lee, Hee Kyung Kim, Seung Won Lee
OBJECTIVES: This study assessed the regenerative efficacy of basic fibroblast growth factor (FGF) in a rabbit model of chronic vocal fold scarring and then confirmed its utility and safety in a prospective trial of patients with this condition. METHODS: FGF was injected three times, at 1-week intervals, into a chronic vocal fold scar created in a rabbit model. After 1 month, mRNA level of procollagen I, hyaluronic acid synthetase 2 (HAS 2), and matrix metalloproteinase 2 (MMP 2) were analyzed by real-time polymerase chain reaction...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/27440130/swallowing-and-aspiration-how-much-is-affected-by-the-number-of-arytenoid-cartilages-remaining-after-supracricoid-partial-laryngectomy
#18
Caner Kılıç, Ümit Tunçel, Metin Kaya, Ela Cömert, Samet Özlügedik
OBJECTIVES: The aim of this study was to compare the effect of the presence of one or two arytenoids on early/late period swallowing-aspiration functions. METHODS: Supracricoid partial laryngectomy (SCPL) with the diagnosis of laryngeal cancer between 2012 and 2014 were retrospectively evaluated. The patients were categorized into two groups as follows: group I, patients who underwent SCPL with one arytenoid cartilage and group II, patients who underwent SCPL with two arytenoid cartilages...
December 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29032664/the-protective-effect-of-egb-761-against-3-nitropropionic-acid-induced-hearing-loss-the-role-of-sirtuin-1
#19
Mun Young Chang, Jihye Rhee, Shin Hye Kim, Young Ho Kim
Objectives: Local administration of 3-nitropropionic acid (3-NP) to the inner ear induces sensorineural hearing loss. Several studies have shown the otoprotective effects of ginkgo biloba extract EGb 761. Moreover, EGb 761 has been reported to activate Sirtuin 1 (SIRT1). The present study was designed to investigate whether EGb 761 prevents 3-NPinduced sensorineural hearing loss and determine its effects on the expression of SIRT1. Methods: Sprague Dawley rats were divided into four experimental groups: control group receiving vehicle of 3-NP, EGb group receiving EGb 761, 3-NP group receiving 3-NP, and EGb+3-NP group receiving EGb 761 and 3-NP...
October 17, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29032663/number-of-metastatic-lymph-nodes-and-ratio-of-metastatic-lymph-nodes-to-total-number-of-retrieved-lymph-nodes-are-risk-factors-for-recurrence-in-patients-with-clinically-node-negative-papillary-thyroid-carcinoma
#20
Chuan-Ming Zheng, Yong Bae Ji, Chang Myeon Song, Ming-Hua Ge, Kyung Tae
Objectives: The number of metastatic lymph nodes (LNs) and the ratio between the number of metastatic LNs and the total number of retrieved LNs (the LN ratio [LNR]) have been proposed as risk factors for recurrence of papillary thyroid carcinoma (PTC). However, the significance of the number of LNs and the LNR in patients with clinically node negative PTC has not been clearly determined. The purpose of this study is to evaluate their significance. Methods: We retrospectively analyzed 382 patients with PTC who had undergone total thyroidectomy with prophylactic central neck dissection (CND) between January 2000 and December 2010...
October 17, 2017: Clinical and Experimental Otorhinolaryngology
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