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Clinical and Experimental Otorhinolaryngology

Sang Kuk Lee, Se A Lee, Sang Woo Seon, Jae Hyun Jung, Jong Dae Lee, Jae Young Choi, Bo Gyung Kim
Objectives: Malignant external otitis (MEO) is a potentially fatal infection of the external auditory canal, temporal bone, and skull base. Despite treatment with modern antibiotics, MEO can lead to skull base osteomyelitis. Until now, there have been few studies on the prognostic factors of MEO. Methods: We performed a retrospective study to identify prognostic factors of MEO, and a meta-analysis of other articles investigating MEO. On the basis of disease progression the 28 patients in our study were divided into 'controlled' and 'uncontrolled' groups, consisting of 12 and 16 patients, respectively...
September 27, 2016: Clinical and Experimental Otorhinolaryngology
Myung Jin Ban, Jae Hong Park, Jae Wook Kim, Ki Nam Park, Jae Yong Lee, Hee Kyung Kim, Seung Won Lee
Objectives: This study assessed the regenerative efficacy of basic fibroblast growth factor (FGF) in a rabbit model of chronic vocal fold scarring and then confirmed its utility and safety in a prospective trial of patients with this condition. Methods: FGF was injected three times, at 1-week intervals, into a chronic vocal fold scar created in a rabbit model. After 1 month, mRNA level of procollagen I, hyaluronic acid synthetase 2 (HAS 2), and matrix metalloproteinase 2 (MMP 2) were analyzed by real-time polymerase chain reaction...
September 27, 2016: Clinical and Experimental Otorhinolaryngology
Hyun Ji Kim, Dae-Young Kim, Jun Ha Hwang, Kyu-Sung Kim
Objectives: To analyze the clinical characteristics of vestibular neuritis patients with minimal canal paresis (canal paresis <25%). Methods: Patients clinically diagnosed with vestibular neuritis and treated at our institute (n=201) underwent otoneurological examination and vestibular function tests. Patients were categorized in terms of the. Results.: of caloric testing (canal paresis<25%, n=58; canal paresis≥25%, n=143). Clinical characteristics and laboratory outcomes were compared between two groups...
September 27, 2016: Clinical and Experimental Otorhinolaryngology
Linghao Zhang, Lu Zhang, Chun-Hong Zhang, Xiao-Bi Fang, Zhen-Xiao Huang, Qing-Yuan Shi, Li-Ping Wu, Peng Wu, Zhen-Zhen Wang, Zhi-Su Liao
Objectives: Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been much studied. Methods: One hundred patients with CRS with nasal polyps (CRSwNP group), 40 patients with CRS without nasal polyps (CRSsNP group), and 100 patients without CRS were enrolled. The difference in lung function was compared. Meanwhile, CRSwNP and CRSsNP group were required to undergo a bronchial provocation or dilation test...
September 8, 2016: Clinical and Experimental Otorhinolaryngology
Hui-Fang Yang, Tung-Wei Kao, Tao-Chun Peng, Yu-Shan Sun, Fang-Yih Liaw, Chung-Ching Wang, Ju-Ting Hsueh, Wei-Liang Chen
Objectives: The effects of serum uric acid (UA) level on a variety of diseases were found from experimental and observational studies via oxidative stress and anti-oxidants. However, research on the association of UA and hearing thresholds is relatively sparse. We investigated this issue in the U.S. general population to evaluate the relationship of serum UA levels and pure tone threshold of hearing. Methods: Forty four thousand eighty four eligible participants aged 20 to 69 years who have serum UA data and received Audiometry Examination Component were enrolled from the National Health and Nutrition Examination Survey 1999-2004...
September 8, 2016: Clinical and Experimental Otorhinolaryngology
Yong Bae Ji, Chang Myeon Song, Eui Suk Sung, Jin Hyeok Jeong, Chang Beom Lee, Kyung Tae
Objectives: To prevent hypoparathyroidism after thyroidectomy, preservation of the parathyroid glands and their vascularity are essential. The aim of this study was to determine the association between postoperative parathyroid function and the viability of the parathyroid glands during thyroidectomy. Methods: We prospectively analyzed 111 patients who underwent total thyroidectomy and in whom all 4 parathyroid glands were preserved in situ during the operation...
August 13, 2016: Clinical and Experimental Otorhinolaryngology
Sung Hoon Yoon, Kyoung Won Nam, Sunhyun Yook, Baek Hwan Cho, Dong Pyo Jang, Sung Hwa Hong, In Young Kim
Objectives: In an effort to improve hearing aid users' satisfaction, recent studies on trainable hearing aids have attempted to implement one or two environmental factors into training. However, it would be more beneficial to train the device based on the owner's personal preferences in a more expanded environmental acoustic conditions. Our study aimed at developing a trainable hearing aid algorithm that can reflect the user's individual preferences in a more extensive environmental acoustic conditions (ambient sound level, listening situation, and degree of noise suppression) and evaluated the perceptual benefit of the proposed algorithm...
August 10, 2016: Clinical and Experimental Otorhinolaryngology
Ertugrul Erhan, Suat Terzi, Metin Celiker, Oguzhan Yarali, Murat Cankaya, Ferda Keskin Cimen, Ismail Malkoc, Bahadir Suleyman
Objectives: The objective of this study is to investigate and evaluate the effect of Hippophae rhamnoides extract (HRE) on oropharyngeal mucositis induced in rats with methotrexate (MTX) through biochemical, gene expression, and histopathological examinations. Methods: Experimental animals were divided into a healthy group (HG), a HRE+MTX (HREM) group, HRE group (HREG), and a control group that received MTX (MTXG). The HREM and HREG groups of rats was administered 50 mg/kg HRE, while the MTXG and HG groups were given an equal volume distilled water with gavage...
August 10, 2016: Clinical and Experimental Otorhinolaryngology
Mohd Normani Zakaria, Aw Cheu Lih, Noor Alaudin Abdul Wahab
No abstract text is available yet for this article.
September 2016: Clinical and Experimental Otorhinolaryngology
Lei Li, Jie Yang, Xiaojiang Li, Xiaoli Wang, Yanxin Ren, Jimin Fei, Yan Xi, Ruimei Sun, Jing Ma
OBJECTIVES: The aim of this study was to investigate the feasibility and safety of percutaneous (125)I seed permanent implantation for advanced hypopharyngeal carcinoma from toxicity, tumor response, and short-term outcome. METHODS: (125)I seeds implant procedures were performed under computed tomography for 34 patients with advanced hypopharyngeal carcinoma. We observed the local control rate, overall survival, and acute or late toxicity rate. RESULTS: In the 34 patients (stage III, n=6; stage IV, n=28), the sites of origin were pyriform sinus (n=29) and postcricoid area (n=5)...
September 2016: Clinical and Experimental Otorhinolaryngology
Young Soo Kim, Dong-Hee Lee, Hiun Suk Chae, Tae-Kyu Lee, Tae Seo Sohn, Seong Cheol Jeong, Hee Yeon Kim, Jae-Im Lee, Jae Yen Song, Chang Dong Yeo, Young Bok Lee, Hyo-Suk Ahn, Mihee Hong, Kyungdo Han
OBJECTIVES: The aim of this study was to determine whether chronic kidney disease (CKD) is associated with hearing thresholds in the nationwide, large-scaled Korean population. METHODS: This study analyzed the data of 9,798 subjects of 19 years and older (4,387 males and 5,411 females). Urine albumin-to-creatinine ratio (ACR) was measured from first-voided spot urine samples. The air-conduction hearing threshold was measured at 0.5, 1, 2, 3, 4, and 6 kHz and pure tone audiogram (PTA) average was calculated as the four-frequency average of 0...
September 2016: Clinical and Experimental Otorhinolaryngology
Jian Yang, Zheng-Cai Lou
No abstract text is available yet for this article.
September 2016: Clinical and Experimental Otorhinolaryngology
So Young Kim, Yoon Joong Kim, Young Ho Kim, Min-Hyun Park
OBJECTIVES: This study was aimed to assess the relationship between the type of temporal bone area involved and conductive hearing loss. METHODS: We enrolled 97 patients who visited the otolaryngology clinics of Seoul National University Hospital or Boramae Medical Center, Seoul Metropolitan Government-Seoul National University with temporal bone fracture between January 2004 and January 2014. Audiometric parameters, including initial and improved air-bone (AB) conduction gap values, were reviewed in accordance with the temporal bone computed tomography (external auditory canal [EAC], middle ear [ME], mastoid [M], and ossicle [O])...
September 2016: Clinical and Experimental Otorhinolaryngology
Dong Hoon Kang, Myoung Jin Lee, Kyu-Yup Lee, Sang Heun Lee, Jeong Hun Jang
OBJECTIVES: To evaluate the factors that limit post-cochlear implantation (CI) speech perception in prelingually deaf children. METHODS: Patients with CI were divided into two groups according to Category of Auditory Performance (CAP) scores 3 years post-CI: the poor performance group (poor performance group, CAP scores≤4, n=41) and the good performance group (good performance group, CAP scores≥5, n=85). The distribution and contribution of the potential limiting factors related to post-CI speech perception was compared...
September 2016: Clinical and Experimental Otorhinolaryngology
Shujun Sun, Xinliang Pan, Limin Zhao, Jianming Zhou, Hongzeng Wang, Yonghong Sun
OBJECTIVES: We sought to identify the expression of CD68-tumor-associated macrophages (TAMs) and CD34-microvascular density (MVD) in laryngeal squamous cell carcinoma (LSCC), to study the relationship with clinical pathological parameters and to determine whether their expression is predictive of disease. METHODS: Pathologically confirmed 45 LSCC tissue and 20 peritumoral non-tumor tissue were examined. Immunohistochemical studies were used to detect the expression of CD68-TAMs and CD34-MVD...
September 2016: Clinical and Experimental Otorhinolaryngology
Kyung Hee Kim, Seung Hoon Woo
OBJECTIVES: It is known that a great extent of radiation is emitted from the medical instruments used in hospitals and that radiation exposure can cause thyroid cancer. However, the correlation between occupational radiation exposure in hospitals and thyroid disease is not extensively recognized. METHODS: The subjects of the study were female nurses, who worked at a single hospital and female, who had undergone a health examination at the same hospital during the same period...
September 2016: Clinical and Experimental Otorhinolaryngology
Mi Jin Mun, Chang-Hoon Lee, Byung-Joo Lee, Jin-Choon Lee, Jeon Yeob Jang, Sung Hoon Jung, Soo-Geun Wang
OBJECTIVES: To clarify the anatomical distribution of the lingual artery in normal adult subjects through histopathologic evaluations. METHODS: Eighteen healthy cadaveric tongues were used to produce 8 paraffin-embedded tissue sections each. Length from midline raphe, depth from dorsum of tongue and the whole transverse length tongue were measured. The lateral distance, depth, and proportion of lateral distance of deep lingual artery were determined from tip to base of tongue gradually...
September 2016: Clinical and Experimental Otorhinolaryngology
Safak Gulec, Ismail Kulahli, Mehmet Ilhan Sahin, Kerem Kokoğlu, Murat Salih Gunes, Deniz Avci, Turan Arli
OBJECTIVES: The purpose is to investigate effect of septoplasty and widened nasal patency on voice quality. METHODS: Fifty patients who undergone septoplasty were included in the study. Thirty-three people who had similar age and distribution were enrolled as control group. Before and 1 and 3 months after surgery, anterior rhinomanometry, voice analysis by Multi-Dimensional Voice Program, and spectrographic analysis were performed to patients. The recordings of /a/ vowel were used to evaluate average fundamental frequency (F0), jitter percent, and shimmer percent...
September 2016: Clinical and Experimental Otorhinolaryngology
Tolgar Lütfi Kumral, Güven Yıldırım, Güler Berkiten, Ziya Saltürk, Enes Ataç, Yavuz Atar, Yavuz Uyar
OBJECTIVES: To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus. METHODS: A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial. After assessing for eligibility, 82 patients were randomly assigned into placebo or trimetazidine groups according to the medication. The trimetazidine group received 20×3 mg/day per oral trimetazidine dihydrochloride and the placebo group received 20×3 mg/day per oral placebo for 3 months...
September 2016: Clinical and Experimental Otorhinolaryngology
Jeong-Seok Choi, Hye-Young An, In Suh Park, Seok-Ki Kim, Young-Mo Kim, Jae-Yol Lim
OBJECTIVES: Radioiodine (RI) therapy is known to subject cellular components of salivary glands (SG) to oxidative stress leading to SG dysfunction. However, the protective effects of antioxidants on RI-induced SG damage have not been well investigated. The authors investigated the morphometric and functional effects of epigallocatechin-3-gallate (EGCG) administered prior to RI therapy and compared this with the effects of amifostine (a well-known antioxidant) in a murine model of RI sialadenitis...
September 2016: Clinical and Experimental Otorhinolaryngology
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