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Clinical and Experimental Otorhinolaryngology

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https://www.readbyqxmd.com/read/30415523/does-rapid-eye-movement-sleep-aggravate-obstructive-sleep-apnea
#1
Sung Hee Kim, Chan Joo Yang, Jong Tae Baek, Sang Min Hyun, Cheon Sik Kim, Sang-Ahm Lee, Yoo-Sam Chung
Objectives: To investigate the apnea-hypopnea index (AHI) according to the sleep stage in more detail after control of posture. Methods: Patients who underwent nocturnal polysomnography between December 2007 and July 2018 were retrospectively evaluated. Inclusion criteria were as follows: age >18 years, sleep efficacy >80%, and patients who underwent polysomnography only in the supine position (100% of the time). Patients were classified into different groups according to the methods: the first, rapid eye movement (REM)-dominant group (AHIREM/AHINREM >2), non-rapid eye movement (NREM)-dominant group (AHINREM/AHIREM >2), and non-dominant group; and the second, light sleep group (AHIN1N2>AHISWS) and slow wave sleep (SWS) group (AHISWS>AHIN1N2)...
November 13, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30404412/hyperbilirubinemia-and-follow-up-auditory-brainstem-responses-in-preterm-infants
#2
Gi-Sung Nam, Sang Hyun Kwak, Seong Hoon Bae, Sung Huhn Kim, Jinsei Jung, Jae Young Choi
Objectives: Neonatal hyperbilirubinemia is considered one of the most common causative factors of hearing loss. Preterm infants are more vulnerable to neuronal damage caused by hyperbilirubinemia. This study aimed to evaluate the effect of hyperbilirubinemia on hearing threshold and auditory pathway in preterm infants by serial auditory brainstem response (ABR). In addition, we evaluate the usefulness of the unconjugated bilirubin (UCB) level compared with total serum bilirubin (TSB) on bilirubin-induced hearing loss...
November 9, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30403838/clinical-characteristics-and-management-of-saccular-cysts-a-single-institute-experience
#3
Joo Hyun Kim, Myeong Hee Kim, Hong Geun Ahn, Hong-Shik Choi, Hyung Kwon Byeon
Objectives: A saccular cyst is defined as a dilated saccule of the larynx, filled with mucus, and is located between the false vocal cords and the thyroid cartilage. Although this uncommon laryngeal condition is benign in nature, it could lead to dyspnea, stridor, and airway obstruction, depending on its size and location. Furthermore, some saccular cysts have been associated with laryngeal carcinoma. This study aimed to characterize this rather uncommon laryngeal condition to aid in determining the proper management of this pathology...
November 8, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30403837/analysis-of-inner-ear-anomalies-in-unilateral-congenital-aural-atresia-combined-with-microtia
#4
Euyhyun Park, Gijeong Lee, Hak Hyun Jung, Gi Jung Im
Objectives: The aim of this study was to analyze the incidence of inner ear anomalies in patients with unilateral congenital aural atresia (CAA) combined with microtia. Methods: We retrospectively reviewed 61 patients with unilateral CAA combined with microtia who underwent high-resolution temporal bone computed tomography (TBCT) and hearing examination. Inner ear anomalies were analyzed using TBCT and evaluated according to the Jahrsdoerfer grading system, Marx classification, and extent of inferior displacement of the mastoid tegmen...
November 7, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30360042/effect-of-ginkgo-biloba-extract-on-n-methyl-d-aspartic-acid-receptor-subunit-2b-expression-in-a-salicylate-induced-ototoxicity-model
#5
Sang-Yeon Lee, Sang Yoon Han, Ye-Ji Shim, Jae-Joon Han, DeukTae Cho, Ji Eun Kim, Young Ho Kim
Objectives: Sodium salicylate (SS) is well known for its ototoxic properties that induce functional and morphological changes in the cochlea and brain. Ginkgo biloba extract (GBE) has been widely used for treatment of various neurodegenerative diseases; however, its effects on salicylate-induced ototoxicity remain unclear. Herein, we examined the effects of EGb 761 (EGb), a standard form of GBE, on the plasticity of the N-methyl-D-aspartate receptor subunit 2B (GluN2B) in the inferior colliculus (IC) following SS administration...
October 27, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30336657/endoplasmic-reticulum-stress-induces-muc5ac-and-muc5b-expression-in-human-nasal-airway-epithelial-cells
#6
Min Han Kim, Chang Hoon Bae, Yoon Seok Choi, Hyung Gyun Na, Si-Youn Song, Yong-Dae Kim
Objectives: Endoplasmic reticulum (ER) stress is known to be associated with inflammatory airway diseases, and three major transmembrane receptors: double-stranded RNA-activated protein kinase-like ER kinase, inositol requiring enzyme 1, and activating transcription factor 6 (ATF6) play important roles in ER stress-related proinflammatory signaling. However, the effects of ER stress and these three major signaling pathways on the regulation of the production of airway mucins in human nasal airway epithelial cells have not been elucidated...
October 20, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30326701/decellularization-of-trachea-with-combined-techniques-for-tissue-engineered-trachea-transplantation
#7
Aysegul Batioglu-Karaaltin, Ercüment Ovali, Mehmet V Karaaltin, Murat Yener, Mehmet Yılmaz, Fatma Eyüpoğlu, Yetkin Zeki Yılmaz, Erol Rüştü Bozkurt, Necdet Demir, Esma Konuk, Ergun Süreyya Bozdağ, Özgür Yiğit, Harun Cansiz
Objectives: The purpose of this study is to shorten the decellularization time of trachea by using combination of physical, chemical, and enzymatic techniques. Methods: Approximately 3.5-cm-long tracheal segments from 42 New Zealand rabbits (3.5±0.5 kg) were separated into seven groups according to decellularization protocols. After decellularization, cellular regions, matrix and strength and endurance of the scaffold were followed up. Results: DNA content in all groups was measured under 50 ng/mg and there was no significant difference for the glycosaminoglycan content between group 3 (lyophilization+deoxycholic acid+de-oxyribonuclease method) and control group (P=0...
October 18, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30326700/virtual-reality-simulators-for-endoscopic-sinus-and-skull-base-surgery-the-present-and-future
#8
Do Hyun Kim, Yeonji Kim, Jae-Sung Park, Sung Won Kim
Endoscopic sinus and skull base surgeries are minimally invasive surgical techniques that reduce postoperative symptoms and complications and enhance patients' quality of life. However, to ensure excellent surgical outcomes after such interventions, intimate familiarity with important landmarks and high-level endoscope manipulation skills are essential. Cadaver training is one possible option, but cadavers are expensive, scarce, and nonreusable and cadaver work requires specialized equipment and staff. In addition, it is difficult to mimic specific diseases using cadavers...
October 18, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30257548/principal-clinical-factors-predicting-therapeutic-outcomes-after-surgical-drainage-of-postoperative-cheek-cysts-experience-from-a-single-center
#9
Sung-Woo Cho, Hyun Jung Lim, Yoonjae Song, Young Kang, Jae Hyun Lim, Yung Jin Jeon, Doo Hee Han, Tae-Bin Won, Dong-Young Kim, Hyun Jik Kim
Objectives: Postoperative cheek cyst (POCC) is a late postoperative complication of radical maxillary sinus surgery including the Caldwell-Luc (C-L) operation. The present study aimed to evaluate the therapeutic outcomes of surgical treatment for POCC and to assess the clinical factors correlated to these outcomes. Methods: This study included 57 patients (67 nostrils) diagnosed with POCC who underwent surgical drainage. The medical records of the patients were retrospectively reviewed for radiological findings, treatment modalities, residual symptoms, and recurrences...
September 28, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30257547/nasality-changes-with-age-in-normal-korean-speaking-adults
#10
Jun Xu, Young-Ae Kang, Soo-Kyoung Park, Young Hoon Yoon, Shang Jie Bai, Yong De Jin, Yong Min Kim, Ki-Sang Rha
Objectives: This study was performed to investigate the effects of aging on nasality and the influence of age-related changes in nasal cavity volume and nasal patency on nasality. Methods: A total of 180 healthy Korean-speaking adult volunteers, who had no nasal or voice-related complaints, were enrolled in this study. Nasometry, acoustic rhinometry, and rhinomanometry were performed to obtain the nasalance score, nasal cavity volume, and nasal resistance, respectively...
September 22, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30196688/robotic-and-endoscopic-thyroid-surgery-evolution-and-advances
#11
Kyung Tae, Yong Bae Ji, Chang Myeon Song, Junsun Ryu
To minimize surgical morbidity and neck scarring, minimally invasive thyroidectomy and robotic/endoscopic thyroidectomy via cervical, axillary, anterior chest, breast, postauricular or transoral approaches have been developed over the past 20 years. In this article, we review the evolution of robotic and endoscopic thyroid surgery and recent advances. Among remote access approaches, the gasless transaxillary approach, bilateral axillo-breast approach, postauricular facelift approach, and transoral vestibular approach are in common use today...
September 11, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30189718/prediction-of-obstructive-sleep-apnea-based-on-respiratory-sounds-recorded-between-sleep-onset-and-sleep-offset
#12
Jeong-Whun Kim, Taehoon Kim, Jaeyoung Shin, Goun Choe, Hyun Jung Lim, Chae-Seo Rhee, Kyogu Lee, Sung-Woo Cho
Objectives: To develop a simple algorithm for prescreening of obstructive sleep apnea (OSA) on the basis of respiratory sounds recorded during polysomnography during all sleep stages between sleep onset and offset. Methods: Patients who underwent attended, in-laboratory, full-night polysomnography were included. For all patients, audio recordings were performed with an air-conduction microphone during polysomnography. Analyses included all sleep stages (i.e., N1, N2, N3, rapid eye movement, and waking)...
September 8, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30189717/is-hyperbaric-oxygen-therapy-effective-in-cisplatin-induced-ototoxicity-in-rats
#13
H Bengu Cobanoglu, Erkan Vuralkan, Abdullah Arslan, Bengusu Mirasoglu, A Savas Toklu
Objectives: Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. The aim of the present study was to evaluate the possible effects of hyperbaric oxygen (HBO) therapy as a protective agent in cisplatin-induced ototoxicity in rats. Methods: A total of 30 adult Wistar rats (60 ears) were divided into five equal groups...
September 8, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30165729/comparison-of-the-clinical-results-of-attic-cholesteatoma-treatment-endoscopic-versus-microscopic-ear-surgery
#14
Mi Rye Bae, Woo Seok Kang, Jong Woo Chung
Objectives: We aimed to compare clinical outcomes including hearing improvement and cholesteatoma recurrence between endoscopic and conventional microscopic surgeries in patients with attic cholesteatoma. Methods: We collected data from patients with attic cholesteatoma who were treated using endoscopic (10 patients) and microscopic (10 patients) approaches by a single surgeon. The data were retrospectively reviewed for patient characteristics, intraoperative findings, hearing levels, and follow-up clinical status...
August 31, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30134647/auditory-deficits-in-patients-with-mild-and-moderate-obstructive-sleep-apnea-syndrome-a-speech-syllable-evoked-auditory-brainstem-response-study
#15
Qiuyang Fu, Tao Wang, Yong Liang, Yong Lin, Xiangdong Zhao, Jian Wan, Suxiao Fan
Objectives.: The energy consumption process of cochlea and neural signal transduction along the auditory pathway are highly dependent on blood oxygen supply. At present, it is under debate on whether the obstructive sleep apnea syndrome (OSAS) would affect the auditory function since the patients suffer from low oxygen saturation. Moreover, it is difficult to detect the functional state of auditory in less severe stage of OSAS. Recently, speech-evoked auditory brainstem response (speech-ABR) has been reported to be a new electrophysiological tool in characterizing the auditory dysfunction...
August 24, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30309200/the-presence-of-neural-stem-cells-and-changes-in-stem-cell-like-activity-with-age-in-mouse-spiral-ganglion-cells-in-vivo-and-in-vitro
#16
Byoung-San Moon, Aswathy Ammothumkandy, Naibo Zhang, Lei Peng, Albina Ibrayeva, Maxwell Bay, Athira Pratap, Hong Ju Park, Michael Anthony Bonaguidi, Wange Lu
OBJECTIVES: Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown. We examined the presence and characteristics of SGN-neural stem cells (NSCs) in mice as a function of age. METHODS: The expression of Nestin and Ki67 was examined in sequentially dissected cochlear modiolar tissues from mice of different ages (from postnatal day to 24 weeks) and the sphere-forming populations from the SGNs were isolated and differentiated into different cell types...
December 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30139232/body-surface-area-is-not-a-reliable-predictor-of-tracheal-tube-size-in-children
#17
Filiz Uzumcugil, Emre Can Celebioglu, Demet Basak Ozkaragoz, Aysun Ankay Yilbas, Basak Akca, Nazgol Lotfinagsh, Bilge Celebioglu
OBJECTIVES: The age-based Cole formula has been employed for the estimation of endotracheal tube (ETT) size due to its ease of use, but may not appropriately consider growth rates among children. Child growth is assessed by calculating the body surface area (BSA). The association between the outer diameter of an appropriate uncuffed-endotrachealtube (ETT-OD) and the BSA values of patients at 24-96 months of age was our primary outcome. METHODS: Cole formula, BSA, age, height, weight and ultrasound measurement of subglottic-transverse-diameter were evaluated for correlations with correct uncuffed ETT-OD...
December 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30021415/common-sites-etiology-and-solutions-of-persistent-septal-deviation-in-revision-septoplasty
#18
Hong Ryul Jin, Dae Woo Kim, Hahn Jin Jung
OBJECTIVES: To investigate the common causes of persistent septal deviation in revision septoplasty and to report the surgical techniques and results to correct them. METHODS: A total of 100 consecutive patients (86 males) who had revision septoplasty due to persistent septal deviation from 2008 and 2014 were included in the study. Their mean age was 35.6 years and the mean follow-up duration was 9.1 months. Presenting symptoms, sites of persistent septal deviation, techniques used to correct the deviation, and surgical results were reviewed...
December 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30021414/initial-nutritional-status-and-clinical-outcomes-in-patients-with-deep-neck-infection
#19
Marn Joon Park, Ji Won Kim, Yonghan Kim, Yoon Se Lee, Jong-Lyel Roh, Seung-Ho Choi, Sang Yoon Kim, Soon Yuhl Nam
OBJECTIVES: The current study aims to determine the correlation between nutritional status upon presentation and disease severity, as well as treatment and survival outcomes. METHODS: Patients who were diagnosed with deep neck infection, underwent at least one surgical drainage/debridement, and had more than 1 week of hospitalization at a tertiary medical center from 2007 to 2015 were retrospectively included. Thereafter, initial serum albumin, C-reactive protein (CRP), and body mass index (BMI) were reviewed...
December 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29973040/immunotherapy-in-head-and-neck-squamous-cell-cancer
#20
Nerina Denaro, Marco Carlo Merlano
Prognosis in relapsed metastatic head and neck squamous cell cancer (RM-HNSCC) is dismal. Platinum based chemotherapy in combination with Cetuximab is used in first-line setting, while no further validated options are available at progression. Immunotherapy has produced durable clinical benefit in some patients with RM-HNSCC although the premises are several patients are nonresponders. Studies are ongoing to determine predictive factors and the ideal setting/combination of novel immunotherapies. In this paper, we discuss the past and present of immunotherapy in head and neck cancer and provide an up-to-date information regarding the potential ways to improve immunotherapy outcomes in HNSCC...
December 2018: Clinical and Experimental Otorhinolaryngology
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