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Current Aging Science

Nurul Aliah Achin, Tan Jen Kit, Wan Zurinah Wan Ngah, Suzana Makpol, Musalmah Mazlan, Hamizah Shahirah Hamezah, Hanafi Ahmad Damanhuri
Background Cognitive frailty emerges as one of the threat to healthy aging. It is in continuum with advancing of age with uncertain indicator between pathological and physiological changes. Alterations in pathways associated to the aging process have been observed including oxidative stress, lipid metabolism, and inflammation. However, the exact mechanisms leading to cognitive decline are still unclear. Objective This study was sought to assess the level of cognitive functions and linked with blood oxidative status during normal aging in rats...
October 19, 2018: Current Aging Science
Dorothy Keine, John Q Walker, Brian K Kennedy, Marwan N Sabbagh
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative condition in which individuals exhibit memory loss, dementia, and impaired metabolism. Nearly all previous single-treatment studies to treat AD have failed, likely because it is a complex disease with multiple underlying drivers contributing to risk, onset, and progression. Here, we explored the efficacy of a multi-therapy approach based on the disease risk factor status specific to individuals with AD diagnosis or concern...
October 18, 2018: Current Aging Science
Raul O Dominguez, Enrique R Marschoff, Liliana M Oudkerk, Luis J Neira, Jorge A Serra
BACKGROUND: Acute systemic diseases (ASD) impact in extended leukoaraiosis (ExL-A) have been seldom described. We study the deterioration in daily life activities (DLA) and cognition associated with ASD events compared with the well described impacts of stroke in patients with leukoaraiosis (L-A). METHODS: Cross-sectional surveys of aged adults from the emergency room after an acute event of ASD or stroke, hospitalized or receiving home care, were followed for one year...
October 18, 2018: Current Aging Science
Jose Roberto Wajman, Leticia Lessa Mansur, Monica Sanches Yassuda
BACKGROUND: Dementias due to neurodegenerative disorders and more specifically, Alzheimer's disease (AD) are the most frequent of all diseases within the industrialized world. Besides this alarming fact, it is noted too that almost three-quarter of people with AD reside in low or middle-income nations. In recent years, cognitive and behavioral neuroscientists have focused on a possible correlation between environmental agents and genetic risk factors for these dementias. METHOD: In this narrative review, a close review of Medical Literature Analysis and Retrieval System was conducted...
October 3, 2018: Current Aging Science
Zsofia Budai, Laszlo Balogh, Zsolt Sarang
BACKGROUND: During aging, muscle tissue undergoes profound changes which lead to a decline in its functional and regenerative capacity. We utilized global gene expression analysis and gene set enrichment analysis to characterize gene expression changes in aging muscle satellite cells. METHOD: Gene expression data; obtained from Affymetrix Mouse Genome 430 2.0 Array, for 14 mouse muscle satellite cell samples (5 young, 4 middle-aged, and 5 aged), were retrieved from public Gene Expression Omnibus repository...
September 24, 2018: Current Aging Science
Maria Helena Vianna Metello Jacob, Rafael Oliveira Fernandes, Jessica Hellen Poletto Bonetto, Roberta Hack Mendes, Alex Sander da Rosa Araujo, Adriane Bello-Klein, Maria Flavia Marques Ribeiro
Dehydroepiandrosterone (DHEA) is an important precursor of active steroid hormone, produced abundantly by the adrenal cortex with an age-dependent pattern. We investigated whether chronic DHEA administration impacts on redox status and on Akt protein activation in skeletal muscle during the aging process (3 and 24 month-old rats). Rats received one weekly dose/5 weeks of DHEA (10 mg/kg) or vehicle. Gastrocnemius muscle was removed to evaluate glutathione system, hydrogen peroxide, antioxidant enzymes, and expression of Akt kinase protein...
August 3, 2018: Current Aging Science
Peter Lloyd-Sherlock, Fransesc Gomez-Olive, Sizzy Ngobeni, Ryan Wagner, Stephen Tollman
Background This paper describes a pilot study to assess the feasibility of a novel intervention to improve the management of hypertension among older people in rural South Africa. Older South Africans have the highest rates of uncontrolled hypertension recorded for any country. Notably, South Africa has a widely-available old age grant (pension), which is delivered on a monthly basis to citizens living in rural villages. Methods We assessed the feasibility of engaging with older people at the point of pension delivery in the Agincourt sub-district of Mpumalanga Province...
July 17, 2018: Current Aging Science
Francisco J Amaro-Gahete, Alejandro de la O, Lucas Jurado-Fasoli, Jonatan R Ruiz, Manuel J Castillo, Angel Gutierrez
Humans have long sought means to extend longevity and counteract the effects of aging on physical and mental functioning. Exercise is a highly effective way for treating and preventing the main causes of morbidity and mortality, most of which are associated with aging. Interestingly, the Klotho gene is involved in the aging process. Indeed, overexpression of the Klotho gene is associated with longevity, and experimental animals lacking this gene seem to develop multiple disorders resembling human aging and present a shortened lifespan...
July 1, 2018: Current Aging Science
Alessandra Barbosa Lopes, Larissa Barbosa Lopes, Roseli Nunes da Silveira Antunes, Josianne Thomazini Fukasawa, Debora de Aguiar Cavaretto, Zamir Calamita
BACKGROUND: Immunosenescence is a remodeling of the immune system, caused by aging, with changes in the function of neutrophils, lymphocytes and Treg cells. OBJECTIVE: This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils), CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation. METHOD: Were studied 49 elderlies (60 years) and 49 adults (35 years). Flow cytometry was used to analyze the expression of surface molecules and the subpopulation of Treg cells, and the results between the groups were compared statistically by the t-test...
June 4, 2018: Current Aging Science
Alexander Lee Houck, Sahba Seddighi, Jane Ann Driver
BACKGROUND: A growing body of epidemiologic evidence suggests that neurodegenerative diseases occur less frequently in cancer survivors, and vice versa. While unusual, this inverse comorbidity is biologically plausible and could be explained, in part, by the evolutionary tradeoffs made by neurons and cycling cells to optimize performance of their very different functions. The two cell types utilize the same proteins and pathways in different, and sometimes opposite, ways. However, cancer and neurodegeneration also share many pathophysiological features...
February 23, 2018: Current Aging Science
Antonino Naro, Vincenzo Cimino, Simona Portaro, Rocco S Calabro
No abstract text is available yet for this article.
2018: Current Aging Science
Debomoy K Lahiri
No abstract text is available yet for this article.
2018: Current Aging Science
Kimberly Y Z Forrest, Adelle M Williams, Marcy J Leeds, Joseph F Robare, Thomas J Bechard
BACKGROUND: Muscle strength is a sensitive indicator of morbidity and mortality in older adults. Loss of muscle strength contributes to a decline in physical functioning. Hand grip strength is a simple measurement but correlated with total body muscle strength. This study evaluated the patterns and correlates of grip strength among older adults in the United States. METHOD: The grip strength data were analyzed from the National Health and Nutrition Examination Survey...
2018: Current Aging Science
Amalia G Diaconeasa, Mariana Rachita
BACKGROUND: Most syndromes of accelerated aging are caused by mutations affecting the integrity of the genetic material. Among them, the most studied is Werner's syndrome, "adult progeria", caused by a recessive autosomal mutation with a frequency of 1 in 10 million, which affects a helicase involved in DNA repair. In Werner syndrome, there is a loss of heterochromatin, though the stability of heterochromatin is also affected in "normal" aging. The Hutchinson-Gilford Progeria Syndrome (HGPS), "child progeria", has an even lower frequency...
2018: Current Aging Science
Daria Segev, Devora Hellerstein, Ayelet Dunsky
BACKGROUND: Physical activity is known for its many health benefits; among them being the positive effect on bone health during the life cycle. During childhood, physical stress stimulates bone remodeling and increases density. However, due to hormonal changes during adulthood, and mainly during postmenopause the rate of bone remodeling is slowed down and is less efficient. As a result, argument has arisen in the literature regarding the benefit or harm of physical activity on bone health among postmenopausal women...
2018: Current Aging Science
Christian W Callaghan
BACKGROUND: Advances in big data analytics can enable more effective and efficient research processes, with important implications for aging research. Translating these new potentialities to research outcomes, however, remains a challenge, as exponentially increasing big data availability is yet to translate into a commensurate era of 'big knowledge,' or exponential increases in biomedical breakthroughs. Some argue that big data analytics heralds a new era associated with the 'end of theory...
2018: Current Aging Science
Nataliya V Savina, Nataliya V Nikitchenko, Tatyana D Kuzhir, Alexander I Rolevich, Sergei A Krasny, Roza I Goncharova
BACKGROUND: DNA helicases maintain genome stability, and their deficiency is associated with disorders resembling premature aging as well as contributes to carcinogenesis. Their functions are determined by the respective genes encoding nucleotide excision repair initiating proteins, e.g. XPD and CSB. OBJECTIVE: The present study aimed to investigate the influence of genetic variations in ERCC2/XPD (rs1799793, rs13181) and ERCC6/CSB (rs2228526, rs2228528) loci on lifespan and developing age-related bladder cancer focusing on homozygous wild type alleles...
2018: Current Aging Science
Fatih Aydin, Esra Betul Kalaz, Canan Kucukgergin, Jale Coban, Semra Dogru-Abbasoglu, Mujdat Uysal
BACKGROUND: Chronic administration of D-galactose (GAL) induces changes that resemble natural aging in rodents. Oxidative stress and Advanced Glycation End products (AGE) formation play a role in GAL-induced aging. Carnosine (CAR; β-alanyl-L-histidine) has antioxidant and anti-glycating actions and may be a potential therapeutic agent in aging due to these properties. The effect of CAR supplementation on AGE levels and oxidative stress parameters was investigated in serum, liver and brain tissues in GAL-treated rats...
2018: Current Aging Science
S Deepashree, T Shivanandappa, S R Ramesh
BACKGROUND: Although genetic variations are heritable, some quantitative traits like longevity may have non-genomic influence on heritability. Laboratory-selected inbred strains of extended longevity phenotype of Drosophila offer an opportunity to study the inheritance of longevity. OBJECTIVE: The aim of the study was to examine the heritability of longevity in an extended longevity phenotype of Drosophila melanogaster using reciprocal cross effects in F1 and F2 generations...
2018: Current Aging Science
Shadi Gharibi, Nuredin Bakhtiari, Elham-Moslemee-Jalalvand, Fatemeh Bakhtiari
BACKGROUND: Age-associated loss of liver function has been recognized for decades. But, the mechanism driving liver regeneration and its decline with age remains elusive. OBJECTIVE: Hence, to support of our previous studies about anti-aging effects of Ursolic Acid (UA), a compound which is extensively present in apple peels. The aim of this study is to address whether UA might alter sensors of the cell metabolic state such as SIRT1, SIRT6, PGC-1β and Klotho proteins...
2018: Current Aging Science
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