journal
MENU ▼
Read by QxMD icon Read
search

Current Aging Science

journal
https://www.readbyqxmd.com/read/28545352/cytoskeleton-anchoring-of-conformational-mutant-like-p53-but-not-shorter-isoforms-p53%C3%AE-and-p47-%C3%AE-n40p53-in-senescent-human-fibroblasts
#1
Koji Nishio
BACKGROUND: Cytoskeleton anchoring of conformational mutant-like p53 is prominent in human senescent cell. The present research investigated the structural basis of vimentin cytoskeleton-anchoring of human p53. METHOD: GFP-fused wild type p53, mutant p53, those of the various truncated isoforms including p53β and p47, were expressed in the vimentin-expressing cells: mouse fibroblasts, COS-7 cells, young and senescent human fibroblasts, and HeLa cells (non-vimentin-expressing)...
May 23, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28494715/the-click-test-a-novel-tool-to-quantify-the-age-related-decline-of-fast-motor-sequencing-of-the-thumb
#2
Florian Bodranghien, Helene Mahé, Benjamin Baude, Mario U Manto, Yves Busegnies, Stéphane Camut, Christophe Habas, Peter Marien, Giovanni de Marco, Kim van Dun
BACKGROUND: The thumb plays a critical role for manual tasks during the activities of daily life and the incidence of neurological or musculoskeletal disorders affecting the voluntary movements of the thumb is high in the elderly. There is currently no tool to assess repetitive motor sequencing of the thumb during ageing. OBJECTIVES: To report a novel procedure (the Click Test) assessing the effects of ageing on fast motor sequencing of the thumb. METHODS: Healthy subjects (n = 252; mean age +/- SD: 49...
May 10, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28412926/acute-symptomatic-seizures-in-geriatric-patients-with-multiple-risk-factors-a-diagnostic-challenge
#3
Ralf Landwehr, Robert Liszka
Acute symptomatic seizures and epileptic disorders are frequent health problems of elderly patients. An early and reliable distinction of the seizure etiology is important to ensure adequate treatment, and to prevent unwarranted diagnostic and therapeutic procedures. The most common causes of acute symptomatic seizures - acute cerebrovascular disorders, metabolic disorders, traumatic brain injury, meningo-encephalitis, cerebral tumors, and withdrawal of alcohol and other central agents - are well-defined and seem to permit straightforward diagnostic and therapeutic strategies...
April 13, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28412925/support-and-social-contact-as-a-decisive-meta-variable-in-morbidity-and-social-welfare-of-the-older-person
#4
Luis Miguel Rondón García, Carmen Castillo Gallego, Francisco José García García, Blanca Aranzazu Aguirre Arizala
This article tackles social support as a meta-variable that is reinforced by a set of social variables, which correlate and act as predictors of social welfare and life quality of the older person with differences according to their gender. In the results of our study, we conclude that the support in general is very good, over 90% of people from the sample have someone who would help if needed. However, support decreases with age in both sexes. On the other hand, we can observe that women have less social resources than men...
April 13, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28412924/neurons-vs-germline-a-war-of-hormetic-tradeoffs
#5
Marios Kyriazis
The process of human ageing is significantly dependent upon events which are currently shaping humanity. One such event is the seemingly inexorable progress of technology, and specifically, digital communications technology. Technology and biology are tightly interconnected, and this has a direct relevance on how our own ageing mechanisms are evolving and adapting to the change. One way technology may affect biological ageing is based on the concept of information exposure which acts as a hormetic stimulus and up-regulates neuronal stress response pathways...
April 13, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28382870/late-versus-early-onset-depression-in-elderly-patients-vascular-risk-and-cognitive-impairment
#6
Abdelhamid H Hashem, Maged Al-Adrousy Gomaa, Mohamed Nasr Elden Sadek, Ola Osama Khalaf
BACKGROUND: Three-quarters of patients with major depressive disorder have late-onset depression. Late-onset depression is more often associated with cognitive impairment than early-onset depression and evidences showed a relationship between vascular factors and late-life depression. OBJECTIVES: To compare cognitive functions between late-onset (≥60 years) and early-onset (<60 years) depression in elderly patients and to highlight the effect of vascular risk factors in elderly patients with late and early onset depression...
April 4, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28302048/protein-tyrosine-nitration-role-in-aging
#7
Bulbul Chakravarti, Deb Narayan Chakravarti
Aging is the inevitable fate of all living organisms, but the molecular basis of physiological aging is still poorly understood. Oxidative stress is believed to play a key role in the aging process. In addition to reactive oxygen species (ROS), reactive nitrogen species (RNS) are generated during aerobic metabolism in living organisms. Protein damage and functional modification by ROS have been demonstrated in details by different investigators. However, compared to protein carbonylation by ROS, fewer studies have been reported on the protein damage by RNS and its implication with the aging process...
March 15, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28302047/neuroinflammation-as-a-common-mechanism-associated-with-the-modifiable-risk-factors-for-alzheimer-s-and-parkinson-s-diseases
#8
Jordan Alexander McKenzie, Lindsay J Spielman, Caitlin B Pointer, Jessica R Lowry, Ekta Bajwa, Carolyn W Lee, Andis Klegeris
Alzheimer's disease (AD) and Parkinson's disease (PD) are among the most common causes of dementia, which increasingly contribute to morbidity and mortality worldwide. A common hallmark in the pathogenesis of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological structures associated with these disorders. Chronic neuroinflammation is sustained by persistent and aberrant microglial activation in the brain, which results in damage and death of neighboring cells, including neurons and glial cells...
March 15, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28215180/metabolic-and-cardiovascular-ageing-indices-in-relation-to-glycated-haemoglobin-in-healthy-and-diabetic-subjects
#9
H I Shruthi Suvarna, Shailaja Moodithaya, Raghava Sharma
Ageing is a natural phenomenon that has tremendous amount of control over normal physiological functions. Evidences suggest that there is a steady increase in glycated haemoglobin levels with age, leading to accumulation of advanced glycation end products (AGE'S) which contributes to the risk of cardiovascular morbidity and mortality. Aim of the study is to evaluate the strength of association of HbA1c with metabolic and cardiovascular ageing indices in subjects between the age group of 40 to 60 yrs. A total of 220 subjects, with (n=110) and without (n=110) diabetes were assessed for the metabolic and cardiovascular ageing indices...
February 16, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28183243/life-history-traits-of-an-extended-longevity-phenotype-of-drosophila-melanogaster
#10
S Deepashree, Thimmappa Shivanandappa, Saraf R Ramesh
BACKGROUND: Aging or senescence is a complex biological phenomenon. Artificially selected Drosophila for extended longevity is one of the experimental models used to understand the mechanisms involved in aging and to test various theories. OBJECTIVE: To examine the life history traits and biochemical defenses in relation to aging in an extended longevity phenotype of Drosophila melanogaster. METHODS: Life history traits viz., survivability, fecundity, development time, dry weight, wing size, lipid content, starvation, desiccation and cold resistances, locomotory ability, antioxidant enzyme activities and reactive oxygen species level between control and selected lines of D...
February 9, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28103780/a-random-forest-induced-distance-based-measure-of-physiological-dysregulation
#11
Ghalib Ayodeji Bello, Gerard Dumancas
Aging involves gradual, multisystemic physiological dysregulation and over time, this degenerative process increases an individual's risk for multiple age-related comorbidities. The ability to quantify age-related physiological dysregulation can provide key insights into the biological mechanisms underlying the aging process and facilitate the development of clinical interventions. Recent studies have introduced and validated a measure of physiological dysregulation based on statistical distance. This measure quantifies the extent of physiological dysregulation in an individual by measuring how much the individual's biomarker profile deviates from the expected average...
January 17, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28088895/investigating-physical-psychological-and-social-wellbeing-of-older-persons-in-jordan
#12
Ayman M Hamdan Mansour, Jumana H Shehadeh, Kathryn Puskar, Mamdouh El-Hneiti, Eman M Haourani
The purpose of this study was to investigate physical, psychological and social wellbeing of older persons. METHODS: cross-sectional explorative design utilizing convenience ≤ of 1058 older persons in Jordan. RESULTS: the three most bothered physical symptoms are; pain in arms, legs, or joints; feeling tired or having low energy; and back pain with percentages of 71.5% (n=756), 69.6% (n=737), and 62.2% (n=754) respectively. Older persons had slight to mild level of depression (M = 17...
January 12, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28236675/the-past-is-never-dead-it-s-not-even-past
#13
Stephen C Bondy
No abstract text is available yet for this article.
January 5, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28042772/factors-of-rapid-cognitive-decline-in-late-onset-alzheimer-s-disease
#14
Pierre Koskas, Mariela Cecile Henry-Feugeas, Jean Paul Feugeas, Phalla Ou, Olivier Drunat
BACKGROUND: Rapid Cognitive Decline (RCD) in Alzheimer Disease (AD) is associated with a worse disease progression. There is no consensual predictor of RCD and only a few studies have focused on RCD in late-onset dementia, the most common form of AD Objective: To identify the predictors of RCD, in a population of community-dwelling patients with recently diagnosed late onset AD Methods: Community-dwelling subjects aged>75 consulting for the first time in Old Age Memory outpatient center from 2009 to 2012 were considered...
January 2, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28042771/oxidative-stress-pro-inflammatory-cytokines-and-antioxidants-regulate-expression-levels-of-micrornas-in-parkinson-s-disease
#15
Kedar N Prasad
Parkinson's disease (PD) is a slow progressive neurodegenerative disease associated with abnormal function of extrapyramidal system. Although several biochemical and genetic defects have been identified, increased oxidative stress and chronic inflammation are one of the earliest events that initiate and promote PD. Oxidative stress also participates in impaired non-motor symptoms.The levels of microRNAs that are evolutionarily conserved single-stranded non-coding RNAs of approximately 22 nucleotide in length are altered in PD...
January 2, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28236676/neurological-concepts-in-ancient-greek-medicine
#16
Marios Kyriazis
No abstract text is available yet for this article.
2017: Current Aging Science
https://www.readbyqxmd.com/read/28236674/review-of-sky-above-clouds-finding-our-way-through-creativity-aging-and-illness
#17
Amr Amin
No abstract text is available yet for this article.
2017: Current Aging Science
https://www.readbyqxmd.com/read/28236673/introduction
#18
Anthony J Turner, Natalia N Nalivaeva, Alexander V Arutjunyan
No abstract text is available yet for this article.
2017: Current Aging Science
https://www.readbyqxmd.com/read/28236672/editorial-denham-harman-pioneer-of-the-free-radical-theory-of-aging
#19
EDITORIAL
Lyudmila S Kozina, Alexander V Arutjunyan
No abstract text is available yet for this article.
2017: Current Aging Science
https://www.readbyqxmd.com/read/27834125/role-of-ageing-and-oxidative-stress-in-regulation-of-amyloid-degrading-enzymes-and-development-of-neurodegeneration
#20
Natalia N Nalivaeva, Anthony J Turner
The accumulation of cerebral amyloid βpeptide (Aβ) is a key precipitating factor for neuronal cell death in Alzheimer's Disease (AD). However, brain Aβ levels are modifiable since there is a balance between its formation from the Amyloid Precursor Protein (APP) and its removal by clearance mechanisms, which can be either through proteolysis or by protein binding and subsequent transport). Among the major enzymes degrading brain Aβ are several zinc-proteases: neprilysin (NEP), its homologues NEP2 and the Endothelin Converting Enzymes (ECE-1 and -2) and also the Insulin-Degrading Enzyme (IDE)...
2017: Current Aging Science
journal
journal
41988
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"