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Current Aging Science

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https://www.readbyqxmd.com/read/30073935/dhea-treatment-effects-on-redox-environment-in-skeletal-muscle-of-young-and-aged-healthy-rats
#1
Maria Helena Vianna Metello Jacob, Rafael Oliveira Fernandes, Jessica Hellen Poletto Bonetto, Roberta Hack Mendes, Alex Sander da Rosa Araujo, Adriane Bello-Klein, Maria Flavia Marques Ribeiro
Dehydroepiandrosterone (DHEA) is an important precursor of active steroid hormone, produced abundantly by the adrenal cortex with an age-dependent pattern. We investigated whether chronic DHEA administration impacts on redox status and on Akt protein activation in skeletal muscle during the aging process (3 and 24 month-old rats). Rats received one weekly dose/5 weeks of DHEA (10 mg/kg) or vehicle. Gastrocnemius muscle was removed to evaluate glutathione system, hydrogen peroxide, antioxidant enzymes, and expression of Akt kinase protein...
August 3, 2018: Current Aging Science
https://www.readbyqxmd.com/read/30019655/pensions-and-low-sodium-salt-a-qualitative-evaluation-of-a-new-strategy-for-managing-hypertension-in-rural-south-africa
#2
Peter Lloyd-Sherlock, Fransesc Gomez-Olive, Sizzy Ngobeni, Ryan Wagner, Stephen Tollman
Background This paper describes a pilot study to assess the feasibility of a novel intervention to improve the management of hypertension among older people in rural South Africa. Older South Africans have the highest rates of uncontrolled hypertension recorded for any country. Notably, South Africa has a widely-available old age grant (pension), which is delivered on a monthly basis to citizens living in rural villages. Methods We assessed the feasibility of engaging with older people at the point of pension delivery in the Agincourt sub-district of Mpumalanga Province...
July 17, 2018: Current Aging Science
https://www.readbyqxmd.com/read/29962352/role-of-exercise-on-s-klotho-protein-regulation-a-systematic-review
#3
Francisco J Amaro-Gahete, Alejandro de la O, Lucas Jurado-Fasoli, Jonatan R Ruiz, Manuel J Castillo, Angel Gutierrez
Humans have long sought means to extend longevity and counteract the effects of aging on physical and mental functioning. Exercise is a highly effective way for treating and preventing the main causes of morbidity and mortality, most of which are associated with aging. Interestingly, the Klotho gene is involved in the aging process. Indeed, overexpression of the Klotho gene is associated with longevity, and experimental animals lacking this gene seem to develop multiple disorders resembling human aging and present a shortened lifespan...
July 1, 2018: Current Aging Science
https://www.readbyqxmd.com/read/29866027/effects-of-immunosenescence-on-the-lower-expression-of-surface-molecules-in-neutrophils-and-lymphocytes
#4
Alessandra Barbosa Lopes, Larissa Barbosa Lopes, Roseli Nunes da Silveira Antunes, Josianne Thomazini Fukasawa, Debora de Aguiar Cavaretto, Zamir Calamita
BACKGROUND: Immunosenescence is a remodeling of the immune system, caused by aging, with changes in the function of neutrophils, lymphocytes and Treg cells. OBJECTIVE: This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils), CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation. METHOD: Were studied 49 elderlies (60 years) and 49 adults (35 years). Flow cytometry was used to analyze the expression of surface molecules and the subpopulation of Treg cells, and the results between the groups were compared statistically by the t-test...
June 4, 2018: Current Aging Science
https://www.readbyqxmd.com/read/29552989/at-the-crossroads-between-neurodegeneration-and-cancer-a-review-of-overlapping-biology-and-its-implications
#5
Alexander Lee Houck, Sahba Seddighi, Jane Ann Driver
BACKGROUND: A growing body of epidemiologic evidence suggests that neurodegenerative diseases occur less frequently in cancer survivors, and vice versa. While unusual, this inverse comorbidity is biologically plausible and could be explained, in part, by the evolutionary tradeoffs made by neurons and cycling cells to optimize performance of their very different functions. The two cell types utilize the same proteins and pathways in different, and sometimes opposite, ways. However, cancer and neurodegeneration also share many pathophysiological features...
February 23, 2018: Current Aging Science
https://www.readbyqxmd.com/read/30095050/looking-towards-new-pathogenetic-mechanisms-in-parkinson-s-disease-is-ant1-the-potential-candidate
#6
Antonino Naro, Vincenzo Cimino, Simona Portaro, Rocco S Calabro
No abstract text is available yet for this article.
2018: Current Aging Science
https://www.readbyqxmd.com/read/30095049/understanding-healthy-protective-mechanisms-against-old-age
#7
Debomoy K Lahiri
No abstract text is available yet for this article.
2018: Current Aging Science
https://www.readbyqxmd.com/read/29150988/patterns-and-correlates-of-grip-strength-in-older-americans
#8
Kimberly Forrest, Adelle Williams, Marcy Leeds, Joseph Robare, Thomas Bechard
BACKGROUND: Muscle strength is a sensitive indicator of morbidity and mortality in older adults. Loss of muscle strength contributes to a decline in physical functioning. Hand grip strength is a simple measurement but correlated with total body muscle strength. This study evaluated the patterns and correlates of grip strength among older adults in the United States. METHODS: The grip strength data were analyzed from the National Health and Nutrition Examination Survey...
November 16, 2017: Current Aging Science
https://www.readbyqxmd.com/read/29149836/are-there-different-kinds-of-aging
#9
Amalia Gabriela Diaconeasa
A critical analysis of the accelerated aging syndromes may explain what aging is, but also why some tissues and organs age at accelerated rates in comparison with aging rates of other tissues. Syndromes of accelerated aging are caused by mutations affecting the integrity of the genetic material. Among them, the most studied is Werner's syndrome, "adult progeria", caused by a recessive autosomal mutation with a frequency of 1 in 10 millions, which affects a helicase involved in DNA repair. In Werner syndrome, there is a loss of heterochromatin, though the stability of heterochromatin is also affected in "normal" aging...
November 16, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28925889/physical-activity-does-it-really-increase-bone-density-in-postmenopausal-women-a-review-of-articles-published-between-2001-2016
#10
Daria Segev, Devora Hellerstein, Ayelet Dunsky
BACKGROUND: Physical activity is known for its many health benefits, among them the positive effect on bone health during the life cycle. During childhood, physical stress stimulates bone remodeling and increases density. However, due to hormonal changes during adulthood, and mainly during postmenopause the rate of bone remodeling is slowed and is less efficient. As a result, argument has arisen in the literature regarding the benefit or harm of physical activity on bone health among postmenopausal women...
September 18, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28721807/developing-the-transdisciplinary-aging-research-agenda-new-developments-in-big-data
#11
Christian William Callaghan
In light of dramatic advances in big data analytics and the application of these advances in certain scientific fields, new potentialities exist for breakthroughs in aging research. Translating these new potentialities to research outcomes for aging populations, however, remains a challenge, as underlying technologies which have enabled exponential increases in 'big data' have not yet enabled a commensurate era of 'big knowledge,' or similarly exponential increases in biomedical breakthroughs. Debates also reveal differences in the literature, with some arguing big data analytics heralds a new era associated with the 'end of theory' or which makes the scientific method obsolete, where correlation supercedes causation, whereby science can advance without theory and hypotheses testing...
July 19, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28707579/the-involvement-of-ercc2-xpd-and-ercc6-csb-wild-type-alleles-in-protection-against-aging-and-cancer
#12
Natalia Savina, Natalia Nikitchenko, Tatyana Kuzhir, Alexander Rolevich, Sergei Krasny, Roza Goncharova
BACKGROUND: DNA helicases maintain genome stability, and their deficiency is associated with disorders resembling premature aging as well as contributes to carcinogenesis. Their functions are determined by the respective genes encoding nucleotide excision repair initiating proteins, e.g. XPD and CSB. OBJECTIVE: The present study aimed to investigate the influence of genetic variations in ERCC2/XPD (rs1799793, rs13181) and ERCC6/CSB (rs2228526, rs2228528) loci on lifespan and developing age-related bladder cancer focusing on homozygous wild type alleles...
July 7, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28676006/carnosine-treatment-diminished-oxidative-stress-and-glycation-products-in-serum-and-tissues-of-d-galactose-treated-rats
#13
Fatih Aydin, Esra Betul Kalaz, Canan Kucukgergin, Jale Coban, Semra Dogru-Abbasoglu, Mujdat Uysal
D-galactose (GAL) has been used as an animal model for aging and antiaging studies. GAL stimulates oxidative stress and increases the formation of advanced glycation end products (AGE) in body fluids and tissues. Carnosine (CAR; β-alanil-L-histidine) exhibits antioxidant and anti-glycating properties. We investigated the effect of CAR supplementation on oxidative stress and AGE levels in serum, liver and brain tissues in GAL-treated rats. Rats received GAL (300 mg/kg; s.c.; 5 days per week) alone or together with CAR (250 mg/kg/daily; i...
July 3, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28641508/is-longevity-a-heritable-trait-evidence-for-non-genomic-influence-from-an-extended-longevity-phenotype-of-drosophila-melanogaster
#14
S Deepashree, Thimmappa Shivanandappa, Saraf R Ramesh
BACKGROUND: Although genetic variations are heritable, some quantitative traits like longevity may have non-genomic influence in heritability. Laboratory-selected inbred strains of extended longevity phenotype of Drosophila offer an opportunity to study the inheritance of longevity. OBJECTIVE: To examine the heritability of longevity in an extended longevity phenotype of Drosophila melanogaster using reciprocal cross effects in F1 and F2 generations. METHODS: Lifespan variations of virgin and mated flies in parent, F1 and F2 generations were investigated using reciprocal crosses between normal and long lifespan lines of inbred population of D...
June 15, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28558631/ursolic-acid-mediates-hepatic-protection-through-enhancing-of-anti-aging-biomarkers
#15
Shadi Gharibi, Nuredin Bakhtiari, Elham-Moslemee Jalalvand
BACKGROUND: Age-associated loss of liver function has been recognized for decades. But, the mechanism driving liver regeneration and its decline with age remains elusive. OBJECTIVE: Hence, to support of our previous studies about anti-aging effects of Ursolic Acid (UA), a compound which extensively present in apple peels. The aim of this study is to address whether UA might alter sensors of the cell metabolic state such as SIRT1, SIRT6, PGC-1β and Klotho proteins...
May 30, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28874111/the-fall-in-older-adults-physical-and-cognitive-problems
#16
REVIEW
Bernard Demanze Laurence, Lacour Michel
BACKGROUND: The aging of posture and balance function alters the quality of life in older people and causes serious problems in terms of public health and socio-economic costs for our modern societies. METHOD: This article reviews the various causes of imbalance and dizziness in the elderly, and considers how to prevent falls, and how to rehabilitate a faller subject in order to regain a good quality of life. Two effective ways of intervention are discussed, emphasizing the crucial role of physical activity and cognitive stimulation, classic or using the latest technical advances in virtual reality and video games...
2017: Current Aging Science
https://www.readbyqxmd.com/read/28545352/cytoskeleton-anchoring-of-conformational-mutant-like-p53-but-not-shorter-isoforms-p53%C3%AE-and-p47-%C3%AE-n40p53-in-senescent-human-fibroblasts
#17
Koji Nishio
BACKGROUND: Cytoskeleton anchoring of conformational mutant-like p53 is prominent in human senescent cells. The present research investigated the structural basis of vimentin cytoskeleton- anchoring of human p53. METHOD: GFP-fused wild type p53, mutant p53, those of the various truncated isoforms including p53β and p47, were expressed in the vimentin-expressing cells: mouse fibroblasts, COS-7 cells, young and senescent human fibroblasts, and HeLa cells (non-vimentin-expressing)...
2017: Current Aging Science
https://www.readbyqxmd.com/read/28494715/the-click-test-a-novel-tool-to-quantify-the-age-related-decline-of-fast-motor-sequencing-of-the-thumb
#18
Florian Bodranghien, Helene Mahe, Benjamin Baude, Mario Manto, Yves Busegnies, Stephane Camut, Christophe Habas, Peter Marien, Giovanni de Marco, Kim van Dun
BACKGROUND: The thumb plays a critical role for manual tasks during the activities of daily life and the incidence of neurological or musculoskeletal disorders affecting the voluntary movements of the thumb is high in the elderly. There is currently no tool to assess repetitive motor sequencing of the thumb during ageing. OBJECTIVES: To report a novel procedure (the Click Test) assessing the effects of ageing on fast motor sequencing of the thumb. METHOD: Healthy subjects (n = 252; mean age +/- SD: 49...
2017: Current Aging Science
https://www.readbyqxmd.com/read/28412926/acute-symptomatic-seizures-in-geriatric-patients-with-multiple-risk-factors-a-diagnostic-challenge
#19
REVIEW
Ralf Landwehr, Robert Liszka
BACKGROUND: Acute symptomatic seizures and epileptic disorders are frequent health problems of elderly patients. An early and reliable distinction of the seizure etiology is important to ensure adequate treatment, and to prevent unwarranted diagnostic and therapeutic procedures. METHODS: We review the current literature based on a MEDLINE search, describe age-related problems in detail, with particular attention to clinical practice, discuss possible criteria and potential pitfalls for diagnostics, and provide a compilation of etiologic factors for acute symptomatic seizures...
2017: Current Aging Science
https://www.readbyqxmd.com/read/28412925/support-and-social-contact-as-a-decisive-meta-variable-in-morbidity-and-social-welfare-of-the-older-person
#20
Luis Miguel Rondon Garcia, Blanca Aranzazu Aguirre Arizala, Francisco Jose Garcia Garcia, Carmen Castillo Gallego
Bacground: This article tackles social support as a meta-variable that is reinforced by a set of social variables, which correlate and act as predictors of social welfare and life quality of the older person. OBJECTIVE: The objective of the study is to know how social support, networks and social contacts can influence the health of the elderly person, especially if these are interrelated factors. METHOD: The population studied are individuals from both sexes living in Toledo (Spanish people) and who were 65 years of age or over...
2017: Current Aging Science
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