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Current Aging Science

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https://www.readbyqxmd.com/read/28302048/protein-tyrosine-nitration-role-in-aging
#1
Bulbul Chakravarti, Deb Narayan Chakravarti
Aging is the inevitable fate of all living organisms, but the molecular basis of physiological aging is still poorly understood. Oxidative stress is believed to play a key role in the aging process. In addition to reactive oxygen species (ROS), reactive nitrogen species (RNS) are generated during aerobic metabolism in living organisms. Protein damage and functional modification by ROS have been demonstrated in details by different investigators. However, compared to protein carbonylation by ROS, fewer studies have been reported on the protein damage by RNS and its implication with the aging process...
March 15, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28302047/neuroinflammation-as-a-common-mechanism-associated-with-the-modifiable-risk-factors-for-alzheimer-s-and-parkinson-s-diseases
#2
Jordan Alexander McKenzie, Lindsay J Spielman, Caitlin B Pointer, Jessica R Lowry, Ekta Bajwa, Carolyn W Lee, Andis Klegeris
Alzheimer's disease (AD) and Parkinson's disease (PD) are among the most common causes of dementia, which increasingly contribute to morbidity and mortality worldwide. A common hallmark in the pathogenesis of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological structures associated with these disorders. Chronic neuroinflammation is sustained by persistent and aberrant microglial activation in the brain, which results in damage and death of neighboring cells, including neurons and glial cells...
March 15, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28215180/metabolic-and-cardiovascular-ageing-indices-in-relation-to-glycated-haemoglobin-in-healthy-and-diabetic-subjects
#3
H I Shruthi Suvarna, Shailaja Moodithaya, Raghava Sharma
Ageing is a natural phenomenon that has tremendous amount of control over normal physiological functions. Evidences suggest that there is a steady increase in glycated haemoglobin levels with age, leading to accumulation of advanced glycation end products (AGE'S) which contributes to the risk of cardiovascular morbidity and mortality. Aim of the study is to evaluate the strength of association of HbA1c with metabolic and cardiovascular ageing indices in subjects between the age group of 40 to 60 yrs. A total of 220 subjects, with (n=110) and without (n=110) diabetes were assessed for the metabolic and cardiovascular ageing indices...
February 16, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28183243/life-history-traits-of-an-extended-longevity-phenotype-of-drosophila-melanogaster
#4
S Deepashree, Thimmappa Shivanandappa, Saraf R Ramesh
BACKGROUND: Aging or senescence is a complex biological phenomenon. Artificially selected Drosophila for extended longevity is one of the experimental models used to understand the mechanisms involved in aging and to test various theories. OBJECTIVE: To examine the life history traits and biochemical defenses in relation to aging in an extended longevity phenotype of Drosophila melanogaster. METHODS: Life history traits viz., survivability, fecundity, development time, dry weight, wing size, lipid content, starvation, desiccation and cold resistances, locomotory ability, antioxidant enzyme activities and reactive oxygen species level between control and selected lines of D...
February 9, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28103780/a-random-forest-induced-distance-based-measure-of-physiological-dysregulation
#5
Ghalib Ayodeji Bello, Gerard Dumancas
Aging involves gradual, multisystemic physiological dysregulation and over time, this degenerative process increases an individual's risk for multiple age-related comorbidities. The ability to quantify age-related physiological dysregulation can provide key insights into the biological mechanisms underlying the aging process and facilitate the development of clinical interventions. Recent studies have introduced and validated a measure of physiological dysregulation based on statistical distance. This measure quantifies the extent of physiological dysregulation in an individual by measuring how much the individual's biomarker profile deviates from the expected average...
January 17, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28088895/investigating-physical-psychological-and-social-wellbeing-of-older-persons-in-jordan
#6
Ayman M Hamdan Mansour, Jumana H Shehadeh, Kathryn Puskar, Mamdouh El-Hneiti, Eman M Haourani
The purpose of this study was to investigate physical, psychological and social wellbeing of older persons. METHODS: cross-sectional explorative design utilizing convenience ≤ of 1058 older persons in Jordan. RESULTS: the three most bothered physical symptoms are; pain in arms, legs, or joints; feeling tired or having low energy; and back pain with percentages of 71.5% (n=756), 69.6% (n=737), and 62.2% (n=754) respectively. Older persons had slight to mild level of depression (M = 17...
January 12, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28042772/factors-of-rapid-cognitive-decline-in-late-onset-alzheimer-s-disease
#7
Pierre Koskas, Mariela Cecile Henry-Feugeas, Jean Paul Feugeas, Phalla Ou, Olivier Drunat
BACKGROUND: Rapid Cognitive Decline (RCD) in Alzheimer Disease (AD) is associated with a worse disease progression. There is no consensual predictor of RCD and only a few studies have focused on RCD in late-onset dementia, the most common form of AD Objective: To identify the predictors of RCD, in a population of community-dwelling patients with recently diagnosed late onset AD Methods: Community-dwelling subjects aged>75 consulting for the first time in Old Age Memory outpatient center from 2009 to 2012 were considered...
January 2, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28042771/oxidative-stress-pro-inflammatory-cytokines-and-antioxidants-regulate-expression-levels-of-micrornas-in-parkinson-s-disease
#8
Kedar N Prasad
Parkinson's disease (PD) is a slow progressive neurodegenerative disease associated with abnormal function of extrapyramidal system. Although several biochemical and genetic defects have been identified, increased oxidative stress and chronic inflammation are one of the earliest events that initiate and promote PD. Oxidative stress also participates in impaired non-motor symptoms.The levels of microRNAs that are evolutionarily conserved single-stranded non-coding RNAs of approximately 22 nucleotide in length are altered in PD...
January 2, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28236675/the-past-is-never-dead-it-s-not-even-past
#9
Stephen C Bondy
No abstract text is available yet for this article.
January 5, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28236676/neurological-concepts-in-ancient-greek-medicine
#10
Marios Kyriazis
No abstract text is available yet for this article.
2017: Current Aging Science
https://www.readbyqxmd.com/read/28236674/review-of-sky-above-clouds-finding-our-way-through-creativity-aging-and-illness
#11
Amr Amin
No abstract text is available yet for this article.
2017: Current Aging Science
https://www.readbyqxmd.com/read/28236673/introduction
#12
Anthony J Turner, Natalia N Nalivaeva, Alexander V Arutjunyan
No abstract text is available yet for this article.
2017: Current Aging Science
https://www.readbyqxmd.com/read/28236672/editorial-denham-harman-pioneer-of-the-free-radical-theory-of-aging
#13
EDITORIAL
Lyudmila S Kozina, Alexander V Arutjunyan
No abstract text is available yet for this article.
2017: Current Aging Science
https://www.readbyqxmd.com/read/27834125/role-of-ageing-and-oxidative-stress-in-regulation-of-amyloid-degrading-enzymes-and-development-of-neurodegeneration
#14
Natalia N Nalivaeva, Anthony J Turner
The accumulation of cerebral amyloid βpeptide (Aβ) is a key precipitating factor for neuronal cell death in Alzheimer's Disease (AD). However, brain Aβ levels are modifiable since there is a balance between its formation from the Amyloid Precursor Protein (APP) and its removal by clearance mechanisms, which can be either through proteolysis or by protein binding and subsequent transport). Among the major enzymes degrading brain Aβ are several zinc-proteases: neprilysin (NEP), its homologues NEP2 and the Endothelin Converting Enzymes (ECE-1 and -2) and also the Insulin-Degrading Enzyme (IDE)...
2017: Current Aging Science
https://www.readbyqxmd.com/read/27739369/free-radical-timer-of-aging-from-chemistry-of-free-radicals-to-systems-theory-of-reliability
#15
Vitaly K Koltover
There are two generally known concepts in biology of aging. Accordingly to the first one, there is a program of aging. The alternative concept advocates that aging proceeds stochastically. In this area of research, free radical-theory of aging, which was put forward by Denham Harman in fifties of XXth century, has determined the most heuristic line. The goal of this review is to demonstrate how the aging program and the aging stochastics are united on the basis of the systems theory of reliability. On this basis, universal features of aging, such as the exponential growth of mortality rate with time and correlation of longevity with the species-specific resting metabolism, are naturally explained...
2017: Current Aging Science
https://www.readbyqxmd.com/read/27719627/role-of-reactive-oxygen-species-in-premature-ageing-of-the-female-reproductive-function
#16
Andrew Korenevsky, Yulia Milyutina, Ljudmila Kozina, Gleb Kerkeshko, Alexander Arutjunyan
Industrial xenobitics, as well as endogenous damaging factors, such as L-homocysteine, are a well-known source of reactive oxygen species that disrupt biological processes. Among many others, luteinizing hormone releasing hormone synthesis and secretion mediated by a variety of neurotransmitters, which are under control of the hypothalamus and pineal gland, may be put in peril by reactive oxygen species. Their formation can be one of the reasons for the reproductive function shutdown in ageing as the generic response to the damaging factors independent of their nature...
2017: Current Aging Science
https://www.readbyqxmd.com/read/27677837/role-of-oxidative-stress-in-the-genesis-of-atherosclerosis-and-diabetes-mellitus-a-personal-look-back-on-50-years-of-research
#17
Vadim Z Lankin, Alla K Tikhaze
We have provided an overview, based on the literature and our data. In accordance with the theory of D. Harman free radical processes cause damages that can accumulate and contribute to aging of the organism. Atherosclerosis and diabetes are developing for a long time so they are manifested predominantly in old age. We found an increase in the level of free radical peroxidation products and decrease in the activity of antioxidant enzymes in the tissues of animals with experimental atherosclerosis. Similar changes were found in the blood of patients with atherosclerosis and aortic autopsy material with atherosclerotic lesions...
2017: Current Aging Science
https://www.readbyqxmd.com/read/27659265/chemical-modification-of-ginsenoside-on-cell-viability-and-cytokine-secretion
#18
Brandi S Betts-Obregon, Magaly Salinas, Dale Oladunni, George R Negrete, Andrew T Tsin
BACKGROUND: Rb1 is a ginsenoside steroid glycoside found exclusively in the plant Panax ginseng. In an earlier report, we showed that Rb1 increased cell proliferation and reduced VEGF (vascular endothelial growth factor) secretion by human retinal pigment epithelial (ARPE19) cells. OBJECTIVE: In the present study, we hypothesized that chemical modification of Rb1 changes the level of VEGF secretion by ARPE19 cells. METHOD: Three derivatives of Rb1 were chemically synthesized by hydrogenation (Rb1-H2), acetylation (Rb1-Acyl), and epoxidation (Rb1-Epoxy)...
2017: Current Aging Science
https://www.readbyqxmd.com/read/27659264/cellular-and-molecular-mechanisms-of-action-of-mitochondria-targeted-antioxidants
#19
Boris A Feniouk, Vladimir P Skulachev
Reactive oxygen species generated in mitochondria are an important factor contributing to mitochondrial and cellular dysfunction underlying many degenerative diseases, chronic pathologies and aging. The idea of delivering antioxidant molecules to mitochondria in vivo to treat these diseases and slow aging intensively developed in the last 20 years. Derivatives of quinones covalently conjugated to a lipophilic cation (e.g., MitoQ and SkQ) were the most extensively studied mitochondria-targeted antioxidants. These compounds have now been used in a wide range of in vitro and in vivo studies, as well as in clinical trials in humans...
2017: Current Aging Science
https://www.readbyqxmd.com/read/27659263/aging-and-ambiguous-ros-system-genetics-analysis
#20
Vladislav S Baranov, Elena V Baranova
Famous Free Radical Theory (FRT) of aging, the 50th year anniversary of which is celebrated in 2015 postulates a crucial role of Reactive Oxygen Species (ROS) in aging. Still it is the most robust theory of aging as mitochondria ROS production (mtROSp) correlates well with four principal ''rules" of aging being universal, endogenous, progressive, and deleterious. Vast number of experiments in different species prove mutagenic effect of ROS and their carcinogenic properties. So far, FRT stimulates the search of new pharmaceuticals with antioxidant activity...
2017: Current Aging Science
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