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Journal of Human Reproductive Sciences

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https://www.readbyqxmd.com/read/27803591/birth-after-human-chorionic-gonadotropin-primed-oocyte-in-vitro-maturation-and-fertilization-with-testicular-sperm-in-a-normo-ovulatory-patient
#1
Claudia González-Ortega, Raul Eduardo Piña-Aguilar, Patricia Cancino-Villareal, Antonio Martin Gutiérrez-Gutiérrez
In this report, we present a case of in vitro maturation (IVM) with surgical retrieved testicular sperm in a normo-ovulatory female. Human chorionic gonadotropin-primed IVM, testicular biopsy for sperm retrieval and intracytoplasmic sperm injection with fresh sperm were performed. Fourteen cumulus-oocyte complexes were obtained in germinal vesicle or metaphase I stage, eight oocytes reached metaphase II, seven presumptive zygotes were obtained, and three cleavage stages embryos in day 2 were transferred producing a singleton pregnancy...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803590/successful-use-of-transcranial-magnetic-stimulation-in-difficult-to-treat-hypersexual-disorder
#2
Adarsh Tripathi, Amit Singh, Harpreet Singh, Sujita Kumar Kar
Hypersexual disorder has phenomenological resemblance with impulsive-compulsive spectrum disorders. Inhibitory repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) has been found to be effective in the management of impulsive-compulsive behaviors. Inhibitory rTMS over SMA may be helpful in hypersexual disorder. We highlight here a case of hypersexual disorder (excessive sexual drive) who failed to respond adequately to the conventional pharmacological treatment and responded with rTMS augmentation...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803589/embryo-genome-profiling-by-single-cell-sequencing-for-successful-preimplantation-genetic-diagnosis-in-a-family-harboring-col4a1-c-1537g-a-p-g513s-mutation
#3
Nayana H Patel, Harsha K Bhadarka, Kruti B Patel, Salil N Vaniawala, Arpan Acharya, Pratap N Mukhopadhyaya, Nilofar R Sodagar
CONTEXT: Genetic profiling of embryos (also known as preimplantation genetic diagnosis) before implantation has dramatically enhanced the success quotient of in vitro fertilization (IVF) in recent times. The technology helps in avoiding selective pregnancy termination since the baby is likely to be free of the disease under consideration. AIM: Screening of embryos free from c.1537G>A; p.G513S mutation within the COL4A1 gene for which the father was known in before be in heterozygous condition...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803588/ficoll-400-density-gradient-method-as-an-effective-sperm-preparation-technique-for-assisted-reproductive-techniques
#4
Hyacinth N Highland, A Sharma Rishika, S Shaikh Almira, P Bansal Kanthi
BACKGROUND: Infertility being a burning issue, the male itself contributes about 40% as a cause, as evident by statistical data. However, Assisted Reproductive Technology (ART) has emerged as a powerful tool in the management of infertility. Sperm preparation techniques govern the selection procedure to separate functional spermatozoa which can then be used in IUI, IVF, and ART and for cryopreservation. AIM: The present study was aimed at evaluation of sperm preparation techniques for reliability, performance and to determine the most effective, feasible and economical technique...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803587/prevalence-of-chromosomal-abnormalities-and-y-chromosome-microdeletion-among-men-with-severe-semen-abnormalities-and-its-correlation-with-successful-sperm-retrieval
#5
Mariano Mascarenhas, Sumi Thomas, Mohan S Kamath, Ramya Ramalingam, Ann Marie Kongari, S Yuvarani, Vivi M Srivastava, Korula George
AIM: To estimate the prevalence of chromosomal abnormalities and Y chromosome microdeletion among men with azoospermia and severe oligozoospermia and its correlation with successful surgical sperm retrieval. SETTING AND DESIGN: A prospective study in a tertiary level infertility unit. MATERIALS AND METHODS: In a prospective observation study, men with azoospermia and severe oligozoospermia (concentration <5 million/ml) attending the infertility center underwent genetic screening...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803586/the-role-of-indian-gynecologists-in-oncofertility-care-and-counselling
#6
Nalini Mahajan, Madhuri Patil, Surleen Kaur, Simrandeep Kaur, Padmaja Naidu
Oncofertility is gaining importance because of increasing cancer incidence, high survivorship, the need to provide a good quality of life to survivors and the desire of patients to preserve their fertility. Disseminating information about the effect of cancer and cancer treatment on fertility and the availability and effectiveness of fertility preservation techniques is critical. Gynaecologists in India act as family physicians and are in a unique position to guide cancer patients on issues of fertility and fertility preservation...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803585/comparative-analysis-of-perinatal-outcome-of-spontaneous-pregnancy-reduction-and-multifetal-pregnancy-reduction-in-triplet-pregnancies-conceived-after-assisted-reproductive-technique
#7
Shilpa Bhandari, Ishita Ganguly, Pallavi Agrawal, Shweta Bhandari, Aparna Singh, Nitika Gupta
INTRODUCTION: With the advent of assisted reproductive treatment options, the incidence of multiple pregnancies has increased. Although the need for elective single embryo transfer is emphasized time and again, its uniform applicability in practice is yet a distant goal. In view of the fact that triplet and higher order pregnancies are associated with significant fetomaternal complications, the fetal reduction is a commonly used option in such cases. This retrospective study aims to compare the perinatal outcome in patients with triplet gestation who have undergone spontaneous fetal reduction (SFR) as against those in whom multifetal pregnancy reduction (MFPR) was done...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803584/gonadotropin-releasing-hormone-agonist-trigger-is-a-better-alternative-than-human-chorionic-gonadotropin-in-pcos-undergoing-ivf-cycles-for-an-ohss-free-clinic-a-randomized-control-trial
#8
Deepika Krishna, Snehal Dhoble, Gautham Praneesh, Suvarna Rathore, Amit Upadhaya, Kamini Rao
OBJECTIVE: The objective of this study is to evaluate if gonadotropin-releasing hormone agonist (GnRHa) trigger is a better alternative to human chorionic gonadotropin (hCG) in polycystic ovary syndrome (PCOS) of Indian origin undergoing in vitro fertilization (IVF) cycles with GnRH antagonist for the prevention of ovarian hyperstimulation syndrome (OHSS). DESIGN: Prospective randomized control trial. SETTING: Tertiary care center. MATERIALS AND METHODS: A total of 227 patients diagnosed with PCOS, undergoing IVF in an antagonist protocol were recruited and randomly assigned into two groups: Group A (study group): GnRHa trigger 0...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803583/use-of-clomiphene-based-stimulation-protocol-in-oocyte-donors-a-comparative-study
#9
Aparna Singh, Shilpa Bhandari, Pallavi Agrawal, Nitika Gupta, Niharika Munaganuru
INTRODUCTION: This study was undertaken to compare between clomiphene citrate (CC) and gonadotropin-releasing hormone antagonist-based protocols in donor-recipient cycles in terms of parameters of ovarian stimulation and obstetric outcome. MATERIALS AND METHODS: Two hundred and three fertile oocyte donors were stimulated using two different protocols: Clomiphene based (n = 103) and antagonist based (n = 100). Donors in the one group were stimulated from day 1 or 2 of spontaneous or withdrawal bleeds with CC (50 mg/day) and recombinant follicle-stimulating hormone (FSH) till the day of trigger while donors in the other group were stimulated using recombinant FSH from day 1 or 2, and the antagonist was added as per flexible antagonist protocol...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803582/impact-of-gonadotropin-releasing-hormone-antagonist-addition-on-pregnancy-rates-in-gonadotropin-stimulated-intrauterine-insemination-cycles
#10
Shikha Jain, Abha Majumdar
OBJECTIVES: The objective of the study is to evaluate the efficacy of gonadotropin-releasing hormone (GnRH) antagonist in improving clinical pregnancy rate in gonadotropin-stimulated intrauterine insemination (IUI) cycles in patients of unexplained infertility. STUDY DESIGN: This was a prospective, randomized case-controlled study. SETTINGS: The study was conducted in the infertility clinic of a tertiary care center. MATERIALS AND METHODS: Four hundred twenty-seven women undergoing IUI following controlled ovarian stimulation with gonadotropins (recombinant follicle-stimulating hormone [r-FSH] 75 IU/day) were randomly divided into two groups...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803581/effect-of-antitubercular-treatment-on-ovarian-function-in-female-genital-tuberculosis-with-infertility
#11
Jai Bhagwan Sharma, J Sneha, U B Singh, Sunesh Kumar, K K Roy, Neeta Singh, Sona Dharmendra
AIM: To evaluate the effect of antitubercular therapy (ATT) on an ovarian function such as ovarian reserve, ovarian dimensions, and ovarian stromal blood flow. SETTINGS AND DESIGN: Prospective study design. MATERIALS AND METHODS: Fifty infertile women with female genital tuberculosis (FGTB) without tubo-ovarian masses diagnosed by positive acid-fast bacilli culture or epithelioid granuloma on endometrial aspirate or positive polymerase chain reaction with positive findings on laparoscopy or hysteroscopy were recruited...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803580/insight-into-the-diagnosis-and-management-of-subclinical-genital-tuberculosis-in-women-with-infertility
#12
REVIEW
Nalini Mahajan, Padmaja Naidu, Simran Deep Kaur
Genital tuberculosis (GTB) is an important cause of infertility in India. Lack of an accurate diagnostic test has led to an indiscriminate use of antitubercular treatment in infertile women. Apart from concerns of drug toxicity, this may be a contributing factor in the increasing incidence of multidrug-resistant TB reported in India. We conducted a study to analyze whether a combination of tests could help improve diagnostic accuracy. An algorithm for the management of GTB in infertile women based on the use of multiple tests is presented...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803579/from-the-editor-s-desk
#13
EDITORIAL
Madhuri Patil
No abstract text is available yet for this article.
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27382242/erratum-microdeletion-of-y-chromosome-as-a-cause-of-recurrent-pregnancy-loss
#14
(no author information available yet)
[This corrects the article on p. 159 in vol. 8, PMID: 26538859.].
April 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27382241/a-rare-balanced-nonrobertsonian-translocation-involving-acrocentric-chromosomes-chromosome-abnormality-of-t-13-15-p11-2-q22-1
#15
Dalvi Rupa, Koppaka Neeraja, Chavan Deepak, Mandava Swarna
BACKGROUND: Balanced non-robertsonian translocation (RT), involving acrocentric chromosomes, is a rare event and only a few cases are reported. Most of the RTs are balanced involving acrocentric chromosomes with the breakpoints (q10;q10). MATERIALS AND METHODS: Chromosome analysis was performed as per standard procedure - Giemsa-trypsin banding with 500 band resolution was analyzed for chromosome identification. RESULTS: In the present study, we report a rare balanced non-RTs involving chromosomes 13 and 15 with cytogenetic finding of 46, XX, t(13;15) (p11...
April 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27382240/an-eventful-journey-from-menarche-to-successful-motherhood
#16
Salil B Chakrabarti, Maureen P Tigga, Jayanta Ray, Amulya Debbarma
Herlyn-Werner-Wunderlich syndrome is an uncommon variant of mullerian duct anomaly and the approach to its diagnosis requires a high index of suspicion and vigilant work up. Presented here is a case of a 26-year-old woman who had the aforementioned anomaly and was pursued for nearly 10 years to provide her with a fruitful obstetric outcome after having undergone Strassman's metroplasty at a young age of 15 years.
April 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27382239/successful-birth-of-south-india-s-first-twins-after-preimplantation-genetic-screening-of-embryos
#17
Priya Selvaraj, Kamala Selvaraj, Kalaichelvi Srinivasan, Mahalakshmi Sivakumar
We report the first documented successful birth of twins following preimplantation genetic screening (PGS) of cleavage stage embryos by array comparative genomic hybridization (CGH) technology, in South India. The case was a 28-year-old woman with the previous history of preclinical pregnancy and a miscarriage in two attempted in vitro fertilization cycles. Day 3 cleavage stage embryos were generated by conventional long protocol with the use of a gonadotropin-releasing hormone analog and a combination of recombinant folliculotropins and human menopausal gonadotropins...
April 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27382238/pregnancy-at-65-risks-and-complications
#18
Shailja Verma, Krishna Agarwal, Gauri Gandhi
A 65-year-old postmenopausal pregnant woman was referred with antepartum hemorrhage at 29 weeks of gestation. Postadmission diagnosed with chronic hypertension, gestational diabetes mellitus, valvular heart disease, and placenta previa. Her pregnancy was terminated by cesarean delivery at 32 weeks as she had a bout of bleeding per vaginum. Most of the placenta was adherent with no plane of cleavage; therefore, cesarean hysterectomy was performed. Baby birth weight was 1650 g and was shifted to nursery for observation and mother needed Intensive Care Unit care postcesarean...
April 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27382237/morphokinetic-behavior-of-euploid-and-aneuploid-embryos-analyzed-by-time-lapse-in-embryoscope
#19
Deven V Patel, Preeti B Shah, Aditi P Kotdawala, Javier Herrero, Irene Rubio, Manish R Banker
BACKGROUND: Embryonic aneuploidy may result in miscarriage, implantation failure, or birth defects. Thus, it is clinically necessary to avoid the selection of aneuploid embryos during in vitro fertilization treatment. AIM: The aim of this study was to identify the morphokinetic differences by analyzing the development of euploid and aneuploid embryos using a time-lapse technology. We also checked the accuracy of a previously described model for selection of euploid embryos based on morphokinetics in our study population...
April 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27382236/effect-of-myomectomy-on-endometrial-cavity-a-prospective-study-of-51-cases
#20
Shilpa Bhandari, Ishita Ganguly, Pallavi Agarwal, Aparna Singh, Nitika Gupta
CONTEXT: Fibroids are the most common tumors of the uterine cavity. Most of them are diagnosed during the reproductive age when the fertility is an important concern for the female. However, complications can occur after removal of fibroid (myomectomy) too for future pregnancy. Though myomectomy has been sighted as a cause of intrauterine adhesions data regarding the effect of myomectomy on endometrial cavity is lacking. AIMS: Evaluate the incidence of intrauterine adhesion formation after myomectomy and to identify the associated factors...
April 2016: Journal of Human Reproductive Sciences
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