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Journal of Human Reproductive Sciences

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https://www.readbyqxmd.com/read/29681721/progesterone-hypersensitivity-a-challenge-for-luteal-support
#1
Astha Gupta, Deepak Goenka, Mohan L Goenka
Progesterone hypersensitivity is a rare phenomenon which can occur after both endogenous and exogenous exposures. We present a case of hypersensitivity to various forms and routes of exogenous progesterone. A 27-year-old female presented with primary infertility. Investigations revealed Grade 1 endometriosis and polycystic ovary syndrome. Three cycles of intrauterine insemination were attempted which were unsuccessful and in vitro fertilization was proceeded. Six blastocysts of Grade A were formed and cryopreserved...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681720/live-birth-after-rescue-in-vitro-maturation-intracytoplasmic-sperm-injection-in-type-1-diabetes-polycystic-ovary-syndrome-patient-using-clomiphene-antagonist-protocol
#2
Samundi Sankari, M Elanchezhian, Divya Selvamani, M Nagarajan, D Gopikrishnan
Infertility in patients with polycystic ovary syndrome (PCOS) associated with diabetes leads to challenging situations seeking alternative treatments. In vitro maturation (IVM) followed by intracytoplasmic sperm injection (ICSI) could overcome the challenges with promising pregnancies in such patients. In the treatment of a 32-year-old diabetic woman who also had PCOS, single immature oocyte was retrieved. Rescue IVM followed by ICSI yielded a grade 1 day 3 embryo which on transferring resulted in pregnancy and a healthy infant was delivered...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681719/intracytoplasmic-sperm-injection-with-assisted-oocyte-activation-resulting-in-successful-pregnancies-and-live-birth-in-couples-with-globozoospermia-a-report-of-two-cases
#3
Puneet Kaur Kochhar, Pranay Ghosh
Globozoospermia, characterized by round-headed acrosomeless sperm, is a rare and severe form of teratozoospermia. We report a successful pregnancy in two cases of total globozoospermia after intracytoplasmic sperm injection (ICSI) with oocyte activation with calcium ionophore. In thefirst case, globozoospermia was diagnosed on the day of oocyte retrieval. Among 11 retrieved oocytes, only one fertilized after ICSI. The pregnancy test 2 weeks after embryo transfer was negative. Two months later, the patient underwent ovarian stimulation again...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681718/therapeutic-efficacy-of-endometrial-scratching-in-repeated-controlled-ovarian-stimulation-cos-failure-cycles
#4
Leena Wadhwa, Mona Mishra
Objective: The objective of the study was (1) "to evaluate the therapeutic efficacy of endometrial scratching in repeated controlled ovarian stimulation (COS) failure cycles." And (2) "to compare differences in pregnancy outcome by endometrial scratching in early (D2-D4) and late follicular phases (D7-D9) of the same stimulation cycle." Materials and Methods: Women attending infertility clinic in a tertiary care center and who have two or more repeated COS failure cycles and planned for COS with intrauterine insemination (IUI) were included in the study which is a prospective parallel, interventional, single-blinded, randomized control study, in 1:1 allocation ratio...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681717/luteinizing-hormone-receptor-gene-and-regulator-of-g-protein-signaling-2-gene-expression-level-and-association-with-oocyte-maturity-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycle
#5
Thanik Chokjirawat, Mutchuporn Sukpresert, Wicharn Choktanasiri, Wanwisa Waiyaput, Duangporn Saengwimol, Aruchalean Taweewongsounton, Tanjitti Pongrujikorn, Chonthicha Satirapod
Aims: The aim is to study the relation and distribution in gene expression level of the luteinizing hormone receptor (LHR) gene and regulator of G-protein signaling 2 (RGS2) gene expression with oocyte maturation. Setting and Design: This cross-sectional study was undertaken in an instruction-based tertiary care infertility unit, department of obstetrics and gynecology. Materials and Methods: After controlled ovarian hyperstimulation, cumulus granulosa cells (CCs) from 59 oocytes among 18 women being treated by in vitro fertilization/intracytoplasmic sperm injection cycle technique from November 2015 to January 2016 were collected on the day of oocyte retrieval...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681716/equivalency-of-in-vitro-fertilization-success-rates-in-elective-single-blastocyst-transfer-and-elective-double-blastocyst-transfer-an-example-of-equivalence-methodology-in-clinical-reproductive-health
#6
Marni B Jacobs, Hillary Klonoff-Cohen, V Gabriel Garzo
Context: When comparing success rates between treatments, it is more appropriate to structure analyses in terms of equivalence rather than traditional analyses that assess differences. Unfortunately, no studies of elective single blastocyst transfer (eSBT) have been conducted in this manner. Aims: The objective of this study was to assess clinical equivalence of in vitro fertilization success rates among patients undergoing eSBT. Settings and Design: A historical prospective study was conducted at a private fertility center...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681715/can-intracytoplasmic-morphologically-selected-spermatozoa-injection-be-used-as-first-choice-of-treatment-for-severe-male-factor-infertility-patients
#7
Geeta Goswami, Meeta Sharma, Deepika Jugga, Devi M Gouri
Aim: This study was carried out to assess the outcome of the intracytoplasmic morphologically selected sperm injection (IMSI) technique compared with the previous failed intracytoplasmic sperm injection (ICSI) attempts in oligoasthenoteratozoospermia (OAT)/severe OAT (SOAT)/teratozoospermia patients. Setting: Institution-based, in vitro fertilization center. Study Design: It was a nonrandomized prospective study including 57 couples who had previous one or two ICSI failures (failure due to no implantation as embryos were transferred in these cycles and had no pregnancy) due to male factor...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681714/tamoxifen-is-better-than-low-dose-clomiphene-or-gonadotropins-in-women-with-thin-endometrium-7-mm-after-clomiphene-in-intrauterine-insemination-cycles-a-prospective-study
#8
Sunita Sharma, Geetha Rani, Gunja Bose, Indranil Saha, Sikha Bathwal, B N Chakravarty
Aim: Gonadotropin stimulation is used as the second line of treatment in patients with thin endometrium following clomiphene citrate (CC) administration, which is associated with higher cost, multiple births, and ovarian hyperstimulation syndrome. Tamoxifen (TMX), a selective estrogen receptor modulator, acts as an agonist on the endometrium. The objective of the present study was to compare the efficacy of low-dose CC, TMX, and gonadotropins in women with thin endometrium (<7 mm) following Clomiphene in intrauterine insemination (IUI) cycles...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681713/does-pretrigger-echogenic-endometrium-in-assisted-reproductive-technology-cycles-reflect-raised-serum-progesterone-level
#9
Monna Pandurangi, N Sanjeeva Reddy, G Usha Rani, Hepzibha Kirubamani
Background: Serum progesterone is the main hormone of the luteal phase. The hyperechoic pattern of the endometrium in the luteal phase is believed to be induced by raised serum progesterone. Serum progesterone is found to be raised cases of controlled ovarian stimulation (COS) cycle on the day of ovulation trigger. Aim: This study aims to find the association between echogenicity of endometrium and raised serum progesterone. Objective: The objective of this study is to determine whether raised pretrigger serum progesterone influences the echogenicity of the endometrium...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681712/effectiveness-of-anti-mullerian-hormone-tailored-protocol-compared-to-conventional-protocol-in-women-undergoing-in-vitro-fertilization-a-randomized-controlled-trial
#10
Sumi Thomas, Mousumi Acharya, K Muthukumar, Achamma Chandy, Mohan S Kamath, T K Aleyamma
Background: Assessment of ovarian reserve before an in vitro fertilization cycle (IVF) is one among the many factors that predicts a successful cycle. Individualized protocol based on ovarian reserve is designed to optimize the pregnancy outcome without compromising the patient safety. Although authors have shown that anti-Mullerian hormone-tailored (AMH) protocols have reduced the treatment burden and improved pregnancy rates, a few others have questioned its efficacy. Aims: The aim of this study was to decide whether the AMH-tailored protocol or the conventional protocol better decides IVF outcomes...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681711/diagnostic-hysterolaparoscopy-for-evaluation-of-infertility-our-experience-in-a-tertiary-care-hospital
#11
Sairem Mangolnganbi Chanu, Gouri Sankar Rudra Pal, Subrat Panda, A S Santa Singh
Objective: The objective of this study is to analyze the role of diagnostic hysterolaparoscopy (DHL) for evaluation of infertility in a tertiary care hospital. Materials and Methods: This retrospective study was conducted from July 2014 to June 2016. Results: Out of 151 patients, 58.28% and 41.72% had primary and secondary infertility, respectively. In primary infertility group 37.5% and in secondary infertility group 49.2% had abnormal findings...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681710/possible-link-between-stress-related-factors-and-altered-body-composition-in-women-with-polycystic-ovarian-syndrome
#12
Barnali Ray Basu, Olivia Chowdhury, Sudip Kumar Saha
Background: Stress is an invisible factor affecting modern day living and is strongly associated with many disease pathogenesis including polycystic ovarian syndrome (PCOS) in women. PCOS is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic dysfunction and body composition alterations. Salivary amylase and cortisol are major stress mediators that have been implicated in PCOS. However, their role in altering body composition in PCOS is yet to be deciphered...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681709/mitochondrial-donation-a-boon-or-curse-for-the-treatment-of-incurable-mitochondrial-diseases
#13
REVIEW
Nishtha Saxena, Nancy Taneja, Prakriti Shome, Shalini Mani
Mitochondria are present in all human cells and vary in number from a few tens to many thousands. As they generate the majority of a cell's energy supply which power every part of our body, and hence, their number varies in different cells as per the energy requirement of the cell. Mitochondria have their own separate DNA, which carries total 13 genes. All of these 13 genes are involved in energy production. For normal functioning of cells, the mitochondria need to be healthy. Unhealthy mitochondria can cause severe medical disorders known as mitochondrial disease...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681708/from-the-editor-s-desk
#14
EDITORIAL
Madhuri Patil
No abstract text is available yet for this article.
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29430160/a-case-of-primary-amenorrhea-with-swyer-syndrome
#15
Pritti K Priya, Vineet V Mishra, Sumesh Choudhary, Jamal S Rizvi
Swyer syndrome with complete gonadal dysgenesis is associated with an absence of testicular differentiation in a phenotypic female with a 46, XY karyotype. A 14-year-old unmarried girl was referred with complaints of primary amenorrhea and nondevelopment of breast. Her built was normal. Examination of her secondary sexual characteristics revealed no breast development, absent axillary hairs, and sparse pubic hairs. External genitalia was of female type. Karyotype showed genotype of 46, XY. Magnetic resonance imaging revealed hypoplastic uterus with absent fallopian tubes and ovaries...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29430159/prevalence-of-cytogenetic-anomalies-in-couples-with-recurrent-miscarriages-a-case-control-study
#16
Vishali Kalotra, Meena Lall, Pushpa Saviour, Ishwar Chander Verma, Anupam Kaur
Background: About 15%-20% of couples get affected by recurrent miscarriages (RM) and chromosomal abnormality in one partner affects 3%-6% of RM couples. Aims: The present study aimed to determine the prevalence of cytogenetic anomalies in couples with RM. Settings and Design: A case-control study was undertaken, in which 243 couples who had experienced 2 or >2 miscarriages were investigated for chromosomal abnormalities and compared with 208 healthy, age-matched control couples who had at least one healthy live born and no history of miscarriages...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29430158/delayed-presentation-of-turner-syndrome-challenge-to-optimal-management
#17
Uma Kaimal Saikia, Dipti Sarma, Yogesh Yadav
Background: Turner syndrome (TS) is a chromosomal disorder associated with dysmorphic features and comorbidities, with recent trends focusing on early diagnosis for adequate management. Aim: The aim is to study the age and mode of presentation of TS, associated comorbidities and look for any correlation with the genotype. Material and Methods: This was a retrospective analysis of girls with TS attending the endocrinology clinic of a tertiary care center...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29430157/pregnancy-outcome-of-home-intravaginal-insemination-in-couples-with-unconsummated-marriage
#18
Kaberi Banerjee, Bhavana Singla
Unconsummated marriage are mainly due to vaginismus or erectile dysfunction. They contribute to about 5% of couples in an infertility clinic. Their incidence is increasing in the metropolitan cities because of stressful lifestyles. Many of couples are advised intrauterine insemination as fertility treatment. However, home insemination is a simple, inexpensive and effective way of achieving pregnancy in such couples. We present the first study to document pregnancy rates of artificial home intravaginal insemination in couples with unconsummated marriage...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29430156/effect-of-endometrial-cavity-fluid-on-pregnancy-rate-of-fresh-versus-frozen-in-vitro-fertilization-cycle
#19
Nitika Gupta, Shilpa Bhandari, Pallavi Agrawal, Ishita Ganguly, Aparna Singh
Objective: This study aims to study the difference in etiology and outcome in terms of implantation rate and abortion rate in fresh (self-stimulated) versus frozen (oocyte donation cycle) in vitro fertilization (IVF) and in transient versus persistent fluid. Material and Methods: This retrospective study was conducted in the Department of Reproductive Medicine of tertiary care center from January 2012 to November 2015. Data were collected retrospectively from the departmental files...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29430155/does-perifollicular-vascularity-on-the-day-of-oocyte-retrieval-affect-pregnancy-outcome-in-an-in-vitro-fertilization-cycle
#20
Nikita Naredi, Santosh Kumar Singh, Rajesh Sharma
Background: The vascularization status of ovarian follicles affects reproductive competence of oocytes and in turn embryo quality by regulating its oxygen supply. Transvaginal power Doppler ultrasound can noninvasively map this vascularity of the ovarian follicles. Thus, we aimed to study the association of perifollicular vascularity and pregnancy outcome in women while on treatment for an in vitro fertilization cycle. Material and Methods: A prospective study on 200 participants evaluated the vascularity of 1008 follicles on the day of oocyte retrieval to outline a map depicting perfusion of each follicle...
October 2017: Journal of Human Reproductive Sciences
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